CN1277037A - Medicine for cardiac and cerebral vascular diseases and hypogona dism and its preparation - Google Patents
Medicine for cardiac and cerebral vascular diseases and hypogona dism and its preparation Download PDFInfo
- Publication number
- CN1277037A CN1277037A CN 00109251 CN00109251A CN1277037A CN 1277037 A CN1277037 A CN 1277037A CN 00109251 CN00109251 CN 00109251 CN 00109251 A CN00109251 A CN 00109251A CN 1277037 A CN1277037 A CN 1277037A
- Authority
- CN
- China
- Prior art keywords
- medicine
- parts
- radix
- semen
- fructus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The medicine consists of ginseng, Radix Ophiopogonis, red sage, Radix Paeoniae Rubra, Rhizoma curculiginis and other ten Chinese medicinal materials. It may be used in treating coronary heart disease, cerebral thrombus, cerebral hemorrgage, vasculitis, phlebitis and other cardiac and cerebral vascular diseases and hypogonadism.
Description
The present invention relates to a kind of medicine for the treatment of cardiovascular and cerebrovascular disease and sexual hypofunction, specific description is that Chinese herbal medicine is the main Chinese patent medicine of forming, the invention still further relates to its preparation method, can be used for treating phlebitis, vasculitis, aging, climacteric syndrome, cerebellar ataxia that arteriosclerosis, hypertension, coronary heart disease, angina pectoris, myocardial infarction, cerebral thrombosis, cerebral hemorrhage, cerebral embolism, cerebral infarction sequela, sexual hypofunction, impotence and premature ejaculation, limbs thromboembolism worn with age, that sclerosis of blood vessels causes cause.
Cardiovascular and cerebrovascular disease is the Senile disease of harm humans health, serious consequence is the mortality rate height, the disability rate height, cause life and financial burden for family and society, the treatment cardiovascular and cerebrovascular disease is a problem that urgency is to be furtherd investigate at present, the sequela that stays for the cardiovascular and cerebrovascular disease acute stage particularly, medical circle needs the technical barrier that solves fast especially.
Both at home and abroad for the medicine of cardiovascular and cerebrovascular disease, following several shortcoming is arranged at present:
1, amcinonide easily causes organism endocrine disorder, edema etc.
2, the anticoagulant medicine causes bleeding easily, and is not all effective to any thrombosis.
3, platelet suppressant drug is only effective to slight thrombosis.
4, the calcium ion antagonist blood pressure lowering is not lasting.
5, the curative effect of medication of free radical resisting is slight.
6, cerebral metabolism activator can only reduce the degree that disables.
More than these medicines also need clinical proportioning, treatment procedure is cumbersome, and all is some chemicals, toxic side effect, untoward reaction, contraindication.
The characteristics that pharmaceutical preparation of the present invention is better than said medicine are exactly the many usefulness of a medicine, can be used for hemorrhagic and ischemic cardiovascular and cerebrovascular disease, can be used as the wide spectrum medicine for treating thrombus.Though the Chinese medicine preparation of a lot of treatment cardiovascular and cerebrovascular disease is arranged,, does not stay sequela after the advantage of medicine of the present invention is cured exactly can all leave deformity in various degree after treating.
The purpose of this invention is to provide a kind of hypoglycemic, improve hypercoagulability, dredge microcirculation, enhancing human body immunity, get through and stop up cardiovascular and cerebrovascular vessel, activation brain cell, recovery function of nervous system, the i.e. pure Chinese herbal and crude drugs preparations of a kind of easily again wide spectrum thromboembolism preventing of economy.
The preparation method that the purpose of this invention is to provide this cardiovascular disease therapies agent.
Solution of the present invention is the theory according to the combination of Chinese and Western medicine, understanding and Therapeutic Principle to disease, achieve with reference to modern pharmacological research, from Chinese medicine, pick out have the replenishing QI and blood qualcomm meridian, the homologous vegetable Chinese herbal medicine of medicated diet that nourishing the liver and kidney, beneficial essence add marrow, by the theory of Chinese medical science prescription, skimming the cream off milk makes its performance eliminate cerebral edema, promotion brain cell metabolism activation, reduce cell injury, repair brain cell, prevent the lipoprotein decomposition, promote carbohydrate metabolism, disperse blood stasis and dredge collateral, makes cardiovascular and cerebrovascular vessel recover the effect of function of nervous system.
Medicine of the present invention is formed (consumption is a weight portion) by following component
Radix Ginseng 3-5 part Nodus Nelumbinis Rhizomatis 50-70 part Caulis Spatholobi 35-45 part
Radix Ophiopogonis 50-70 part Myrrha 20-30 part Semen Lablab Album 20-30 part
Radix Salviae Miltiorrhizae 100-120 part Pollen Typhae 20-30 part Fructus Crataegi dry slice 40-50 part
Radix Paeoniae Rubra 30-50 part Semen Sesami 30-40 part Semen Juglandis 30-35 part
Rhizoma Curculiginis 10-20 part Fructus Hordei Germinatus 20-30 part is fried Fructus Capsici 5-10 part
Preparing medicine optimum ratio weight range of the present invention is:
Radix Ginseng 2-4 part Nodus Nelumbinis Rhizomatis 40-60 part Caulis Spatholobi 30-40 part
Radix Ophiopogonis 40-60 part Myrrha 15-20 part Semen Lablab Album 20-25 part
Radix Salviae Miltiorrhizae 90-100 part Pollen Typhae 15-20 part Fructus Crataegi dry slice 30-40 part
Radix Paeoniae Rubra 25-40 part Semen Sesami 30-35 part Semen Juglandis 25-30 part
Rhizoma Curculiginis 10-15 part Fructus Hordei Germinatus 20-25 part is fried Fructus Capsici 5-8 part
Medicine optimum weight proportioning of the present invention is:
60 parts of 50 portions of Caulis Spatholobis of 3 parts of Nodus Nelumbinis Rhizomatis of Radix Ginseng 30 parts of Radix Ophiopogonis
20 parts of 90 parts of Pollen Typhaes of 20 parts of Radix Salviae Miltiorrhizaes of 25 portions of Semen Lablab Albums of Myrrha
35 parts of 35 parts of Semen Juglandiss of 35 portions of Semen Sesamis of 50 parts of Radix Paeoniae Rubra of Fructus Crataegi dry slice
15 parts of Fructus Hordei Germinatus of Rhizoma Curculiginis are fried 5 parts in Fructus Capsici for 30 parts
Above-mentioned each component is made medicine production method of the present invention is:
1, earlier that Fructus Capsici is air-dry, fry into the blackout color and cross 120 mesh sieves.
2, Radix Ginseng, Semen Juglandis, Seem Lablab Album, Pollen Typhae, Semen Sesami, Radix Ophiopogonis, Myrrha are pulverized 120 order fineness.
3, getting Radix Salviae Miltiorrhizae Radix Paeoniae Rubra, Rhizoma Curculiginis, Nodus Nelumbinis Rhizomatis, Fructus Hordei Germinatus, Caulis Spatholobi, Fructus Crataegi dry slice washes and adds 300 degrees centigrade of decoctions of 10 times of water gagings surplus 200 gram extracts of every kilogram of medical material of back simmer down to that remove slag.
4, with medicine juice with after medicated powder mixes, air-dry pulverizing 120 order fineness, tablet or powder (powder promptly is electuary) are made in ripening sterilization 30 minutes.
5, also 200 degrees centigrade of decoctings of this prescription medicine can be boiled every kilogram and make 2 kilograms of medicinal liquids and add 1 kilogram of yellow wine, make oral liquid, after filtration precipitation, autoclaving, bottling.
An important feature of the present invention is exactly to contain abundant nutrition in the medicament, and wherein vegetable protein is rich in 16 seed amino acids up to 10%, is to strengthen vagus nerve to supply with adjust blood pressure, enhancing cell humoral immunization, the indispensable material of nutrient vessel.
Various amino acid profiles contain scale in the medicine of the present invention:
| Title | Content (mg/100g) | Title | Content (mg/100g) | Title | Content (mg/100g) |
| Threonine | 412.8 | Aspartic acid | 210.2 | Alanine | 851.2 |
| Glutamic acid | 454.6 | Phenylalanine | 607.9 | Glycine | 356.2 |
| Arginine | 643.3 | Isoleucine | 539.6 | Serine | 508.6 |
| Histidine | 202.4 | Valine | 788.9 | Tryptophan | 210.1 |
| Leucine | 1015.0 | Tyrosine | 340.5 | ||
| Lysine | 434.2 | Proline | 490.0 |
To be rich in potassium, magnesium, phosphorus, ferrum, calcium, selenium and other trace elements in the combination agent of the present invention be to endocrine adjusting and strengthen the indispensable material of hematopoietic function, each chemical element content such as following table in the medicine of the present invention:
| Title | Content (mg/100g) | Title | Content (mg/100g) | Title | Content (mg/100g) |
| Potassium chromium chromium | ??835.2 ??169.6 | Zinc-magnesium | ??19.8 ??1510 | The selenium phosphorus calcium | ????0.15 ????321.2 ????1320 |
Another important feature is to contain abundant vitamin E, C, A multiple nutrients material in the medicament among the present invention, and the brain cell of promotion metabolism activation is arranged, and reduces and organizes oxygen consumption to remove free radical enhancing tissue to anoxybiotic toleration; The water-soluble fibre cellulose content reaches 7-25% and can promote gastrointestinal emptying in the medicament of the present invention, reduce the absorption of glycolipid fat, contain abundant choline material and flavone compound in this medicament, content be 1.5-3.1% can blood fat reducing, fall blood sticking, promote microcirculation, increase the heart and brain blood perfusion, the logical again and side that helps cardiovascular and cerebrovascular vessel is propped up circulation foundation, medicament clinical trial of the present invention has following advantage:
1, prescription of the present invention is compatible with natural food medicine and natural medical Chinese crude drug, utilize the comprehensive function of each herbal medicine, the treatment cardiovascular and cerebrovascular disease, also can treat the diabetes close with cardiovascular and cerebrovascular vessel, the blood fat reducing of energy blood sugar lowering, worn with age, the sexual hypofunction that sclerosis of blood vessels causes, aging, climacteric syndrome etc.
Medicine of the present invention is nutritious, and no bitterness, sour and sweet palatability, no chemical addition agent, nontoxic conform to national pharmaceutical control law and food hygiene law.
Medicine of the present invention has no side effect, has no adverse reaction, does not have contraindication.
The characteristics of medicine of the present invention are that plant nutrient medicine and drug for invigorating blood circulation and eliminating stasis are compatible and be equipped with hemostasis and do not stay the stasis of blood, blood stasis dispelling and not hemorrhage medicine, can be used for all types of cardiovascular and cerebrovascular diseases, broken through the single shortcoming of curative effect of medicine, is a kind of wide spectrum medicine for treating thrombus of pure Chinese medicinal preparation.Characteristics of the present invention are that the treatment cardiovascular and cerebrovascular disease does not stay sequela, also can treat old angiopathy sequela patient, reach the hypothyroid disease of therapeutic by the treatment cardiovascular and cerebrovascular disease, balancing blood pressure, curative effect is lasting, can be used for hypertension and hypotensive treatment, solved the difficult problem that hypertension relies on medicine for a long time, desirable what a kind of medicine for the treatment of cerebrovascular of acting as.
The effect that medicine of the present invention is treated cardiovascular and cerebrovascular vessel: apoplexy sequela paralysis, hemiplegia, brain atrophy, take that thrombolytic glue is assisted, brain ruton, network be glad logical etc., all not having positive effect took medicine 1-3 of the present invention month, paralysis can be taken care of oneself, hemiplegia recovers normal, and brain atrophy, mental retardation recovery extent are more than 90%.Early stage with medicine treatment cardiovascular and cerebrovascular vessel thrombosis of the present invention, treated one month, do not stay any sequela.
For showing that the present invention treats hypertensive curative effect, observe through clinical 50 examples, select medical history, the state of an illness, age, sex, and 50 suitable routine matched groups of former Therapeutic Method, stipulated adult hyperpietic man 20 examples that hypertensive diagnostic criteria is made a definite diagnosis in 1978 according to World Health Organization (WHO), woman's 30 examples, age 40 is to 75 years old, and course of disease half a year to 30 year, blood pressure is more than 180/100 millimetres of mercury, test group is inactive depressor on former treatment basis, obey medicine of the present invention, matched group is blood pressure lowering routinely, treats two months, instructions of taking: each 0.5g, day obeys 3 times, and boiled water is taken after mixing it with water, clinical test results such as following table:
Table one: mm mercury column
For showing the curative effect of Drug therapy cerebrovascular of the present invention, clinically select case 35 people, take medicine of the present invention, it is glad logical that matched group 30 people take network, took simultaneously two months, and curative effect shows as a result:
Table 2: medicine of the present invention is obeyed 3 times every day, each 0.5g
| Case load | Network is glad logical | Medicine of the present invention | |||
| Before | After | Before | After | ||
| Test group | ????35 | Paralysis facial hemiparalysis hemiplegia | Recovering orthobiosis takes care of oneself | ||
| Matched group | ????30 | The hemiplegia myasthenia of limbs | Do not have obviously and improve | ||
The effect of blood fat reducing of the present invention shows: test group 60 people take the each 0.5g of medicine of the present invention and serve on 2 months every days 3 times, and matched group 60 people took Elasterin 3 months.
Table 3: medicine of the present invention and the average concentration change of Elasterin contrast blood fat:
| Case | The Elasterin consumption | Serum cholesterol meansigma methods mmoL/L | Serum levels of triglyceride meansigma methods mmoL/L | ||||
| Before | After | Before | After | Before | After | ||
| Test group contrast level | ?60 ?60 | ????0 ?400mg | ????0 ?400mg | ?5.73±1.10 ?5.67±1.06 | ?4.50±0.70 ?5.10±0.99 | ?2.14±1.09 ?2.09±0.91 | ?1.20±0.55 ?2.02±0.30 |
Test shows that pharmaceutical treatment hypertension, hyperlipemia of the present invention, the cerebral infarction person that obtains the significant curative effect accounts for 100% cure rate and accounts for 95/100.
Embodiment:
Take by weighing raw material by following proportioning:
Radix Ginseng: 3 kilograms; 50 kilograms of Nodus Nelumbinis Rhizomatis; Caulis Spatholobi: 30 kilograms; Radix Ophiopogonis: 60 kilograms; Myrrha: 25 kilograms; Semen Lablab Album: 20 kilograms; Radix Salviae Miltiorrhizae: 90 kilograms; Pollen Typhae: 20 kilograms; Fructus Crataegi dry slice: 50 kilograms; Radix Paeoniae Rubra: 35 kilograms; Semen Sesami: 35 kilograms; Semen Juglandis: 35 kilograms; Rhizoma Curculiginis: 15 kilograms; Fructus Hordei Germinatus: 30 kilograms; Fry Fructus Capsici: 5 kilograms.
Production method is as follows:
1, earlier the air-dry stir-fry blackout of Fructus Capsici is pulverized 120 order fineness;
2, with Radix Ginseng, Semen Juglandis, Seem Lablab Album, Pollen Typhae, Semen Sesami, Radix Ophiopogonis, Myrrha, pulverizing 120 order fineness;
3, get Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Curculiginis, Nodus Nelumbinis Rhizomatis, Fructus Hordei Germinatus, Caulis Spatholobi, Fructus Crataegi dry slice and clean, add 300 degrees centigrade of decoctions of 10 times of water gagings, after removing slag, the surplus 200 gram extracts of every kilogram of medical material of simmer down to;
4, with medicine juice with after medicated powder mixes, air-dry pulverizing 120 order fineness, tablet or powder are made in ripening sterilization 30 minutes;
5, also the medicinal 200 degrees centigrade of decoctings of the present invention can be boiled, every kilogram of medical material is made 2 kilograms of medicinal liquids, adds 1 kilogram of yellow wine, makes oral liquid, after filtration, precipitation, high pressure, sterilization, bottling.
Each oral 05 gram of powder tablet, oral liquid are obeyed 50 milliliters of every days 3 times at every turn.
Claims (7)
1, a kind of medicine for the treatment of cardiovascular and cerebrovascular disease and sexual hypofunction is characterized in that it is the medicament of being made by the raw material of following weight ratio.
Radix Ginseng 3-5 part Nodus Nelumbinis Rhizomatis 50-70 part Caulis Spatholobi 35-45 part
Radix Ophiopogonis 50-70 part Myrrha 20-30 part Semen Lablab Album 20-30 part
Radix Salviae Miltiorrhizae 100-120 part Pollen Typhae 20-30 part Fructus Crataegi dry slice 40-50 part
Radix Paeoniae Rubra 30-50 part Semen Sesami 30-40 part Semen Juglandis 30-35 part
Rhizoma Curculiginis 10-20 part Fructus Hordei Germinatus 20-30 part is fried Fructus Capsici 5-10 part
2, according to the medicine of described treatment cardiovascular and cerebrovascular vessel of claim 1 and sexual function, wherein each proportion of raw materials is:
Radix Ginseng 2-4 part Nodus Nelumbinis Rhizomatis 40-60 part Caulis Spatholobi 30-40 part
Radix Ophiopogonis 40-60 part Myrrha 15-20 part Semen Lablab Album 20-25 part
Radix Salviae Miltiorrhizae 90-100 part Pollen Typhae 15-20 part Fructus Crataegi dry slice 30-40 part
Radix Paeoniae Rubra 25-40 part Semen Sesami 30-35 part Semen Juglandis 25-30 part
Rhizoma Curculiginis 10-15 part Fructus Hordei Germinatus 20-25 part is fried Fructus Capsici 5-8 part
3, the medicine of treatment cardiovascular and cerebrovascular vessel according to claim 1 and sexual function, wherein the weight proportion of middle raw material is:
30 parts of 50 portions of Caulis Spatholobis of 3 parts of Nodus Nelumbinis Rhizomatis of Radix Ginseng
20 parts of 25 portions of Semen Lablab Albums of 60 parts of Myrrhas Radix Ophiopogonis
50 parts of 20 parts of Fructus Crataegi dry slice of 90 parts of Pollen Typhaes of Radix Salviae Miltiorrhizae
35 parts of 35 portions of Semen Juglandis of 35 portions of Semen Sesamis of Radix Paeoniae Rubra
15 parts of Fructus Hordei Germinatus of Rhizoma Curculiginis are fried 5 parts in Fructus Capsici for 30 parts
4,, it is characterized in that said medicament is a said dosage form on any pharmaceutics according to the medicine of claim 1,2,3 described treatment cardiovascular and cerebrovascular disease and sexual function.
5,, it is characterized in that said medicament is arranged is powder, tablet or decoction according to the medicine of described treatment cardiovascular of claim 4 and sexual function.
6, according to the medicine of described treatment cardiovascular and cerebrovascular vessel of claim 5 and sexual function, it is characterized in that getting earlier Fructus Capsici air-dry, fry black 120 orders of pulverizing, get Semen Juglandis Radix Ginseng, Seem Lablab Album, Pollen Typhae, Semen Sesami, Radix Ophiopogonis, Myrrha, pulverizing 120 orders, getting Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Curculiginis, Nodus Nelumbinis Rhizomatis, Fructus Hordei Germinatus, Caulis Spatholobi, Fructus Crataegi dry slice again washes, add 300 degrees centigrade of decoctions of 10 times of water gagings, the back of removing slag concentrates the surplus 200g extract of every kilogram of medical material, with medicine juice mix with medicated powder, air-dry, pulverize 120 orders, tablet or powder were made in the ripening sterilization in 30 minutes.
7, according to the medicine of described treatment cardiovascular and cerebrovascular vessel of claim 5 and sexual function, it is characterized in that 200 degrees centigrade of decoctings of medicine of the present invention are boiled, make 2 kilograms of medicinal liquids for every kilogram, add 1 kilogram of yellow wine, make oral liquid, after filtration, the precipitation, the bottling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00109251 CN1277037A (en) | 2000-06-20 | 2000-06-20 | Medicine for cardiac and cerebral vascular diseases and hypogona dism and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00109251 CN1277037A (en) | 2000-06-20 | 2000-06-20 | Medicine for cardiac and cerebral vascular diseases and hypogona dism and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1277037A true CN1277037A (en) | 2000-12-20 |
Family
ID=4579531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00109251 Pending CN1277037A (en) | 2000-06-20 | 2000-06-20 | Medicine for cardiac and cerebral vascular diseases and hypogona dism and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1277037A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101043898B (en) * | 2004-10-01 | 2012-12-12 | 索法股份公司 | The use of winter savory(satureja montana) or the extracts thereof for the preparation of medicaments for the treatment of the premature ejaculation |
-
2000
- 2000-06-20 CN CN 00109251 patent/CN1277037A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101043898B (en) * | 2004-10-01 | 2012-12-12 | 索法股份公司 | The use of winter savory(satureja montana) or the extracts thereof for the preparation of medicaments for the treatment of the premature ejaculation |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1051237C (en) | Meicinal prepn. "Kexianling" for curing epilepsy | |
| CN1066945C (en) | Chinese drug Mingmudan pill for improving eyesight and its producing method | |
| CN1058614C (en) | Galenic composition | |
| CN1853702A (en) | Chinese medicinal preparation for lowering blood sugar, blood fat and blood pressure, improving blood flow and immune and its making method | |
| CN1879802A (en) | Nutritious Chinese medicinal product for replenishing liver and kidney, resisting senility, decreasing blood fat, blood sugar and blood pressure and method for preparing same | |
| CN1939506A (en) | Vision-improving preparation with depressor, blood-sugar and blood-fat lowering functions and its making method | |
| CN1478508A (en) | Chinese medicinal composition for treating fatty liver and its preparation method | |
| CN1799582A (en) | Blood sugar- and blood pressure-lowering medicine | |
| CN1857599A (en) | Medicine for lowering blood sugar, blood fat and blood pressure, raising blood flow rate and raising immunity and its preparing method | |
| CN1277037A (en) | Medicine for cardiac and cerebral vascular diseases and hypogona dism and its preparation | |
| CN1248698C (en) | Drug for treating coronary heart disease or coronary disease and cardiac insufficiency, and its preparation method | |
| CN1063649C (en) | Red ginseng and hawthorn fruit health-care wine | |
| CN1045892C (en) | Chinese medicine Guanxintong for preventing and curing coronary heart disease and angina pectoris, and producing process thereof | |
| CN1899385A (en) | Process for preparing Chinese medicine compound injection for treating chronic renal failure and use | |
| CN1085546C (en) | Medicine for curing coronary heart disease, arteriosclerosis and hypertension | |
| CN1272054C (en) | Medicine for treating diabetes and its preparing process | |
| CN1201811C (en) | Chinese medicine composition for treating myopia and preparing method thereof | |
| CN1265805C (en) | Chinese medicine oral preparation for lonering blood sugar and its preparation method | |
| CN100340232C (en) | Jinshu leaf styptic mixture and its preparing method and use | |
| CN1490036A (en) | Chemical for promoting growth of hairs and preventnig sinility | |
| CN1850265A (en) | Chinese medicine for treating nephrosis Yang deficiency syndrome | |
| CN1520859A (en) | Cerebrovascular and cardiovascular disease treating injection containing red-rooted salvia and safflower | |
| CN1263490C (en) | Yang reinforcing medicine and its preparation method | |
| CN1218697C (en) | Pharmaceutical composition for treating or improving arthritis and diet extender | |
| CN101040920A (en) | Drug for curing nephrosis and its preparing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |