CN1274319C - Medical use of phytosterone component in Radix Rhapontici - Google Patents
Medical use of phytosterone component in Radix Rhapontici Download PDFInfo
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- CN1274319C CN1274319C CN 00110672 CN00110672A CN1274319C CN 1274319 C CN1274319 C CN 1274319C CN 00110672 CN00110672 CN 00110672 CN 00110672 A CN00110672 A CN 00110672A CN 1274319 C CN1274319 C CN 1274319C
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- ketosteroid
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Abstract
The present invention relates to the medical use of plant sterone components in the uniflower swisscentaury root of traditional Chinese medicine. The new use of the plant sterone components in the uniflower swisscentaury root is provided, and a new path for developing the uniflower swisscentaury root of the traditional Chinese medicine is provided. The plant sterone components in the uniflower swisscentaury root can be used for preparing medicine treating osteoporosis, can be used for preparing the medicine inhibiting the activity of bone resorption and promoting DNA of cartilage cells, and can be used for preparing the medicine having mentality improving effect and antioxidation. The present invention has better curative effect on treating osteoporosis.
Description
The present invention relates to medical technical field, exactly it is the medical usage of plant ketosteroid composition in the Chinese medicine Radix Rhapontici.
Centaurea monanthos Georgi [Rhaponticum uniflorum (L.) DC] is that the Compositae Radix Rhapontici belongs to herbaceos perennial, and main product is in the ground such as Hebei, Liaoning, the Inner Mongol and Shaanxi of China, and medicinal its root is the Chinese medicine Radix Rhapontici.Since the forties in this century, Chinese scholar is carried out the research of chemical constituent and pharmacologically active aspect to the Chinese medicine Radix Rhapontici, up to the present therefrom get and comprise sterone, organic acid, flavone, thiophene, sterol, higher fatty acids, terpenoid etc. are at 30 interior number of chemical compositions, the research of pharmacologically active aspect simultaneously then mainly concentrates on anti peroxidation of lipid, nootropics, study of anti-atherogenic effect and immunoregulation effect, the inventor carries out comprehensive and systematic chemistry and pharmacological research to Radix Rhapontici since the early 1990s, and the method that combines by modern pharmacology experimental technique and phytochemistry method, find that the plant ketosteroid composition in the Radix Rhapontici is its effective site, and proof Radix Rhapontici total sterone can significantly improve dysmnesia, and has anti-hypoxia, effects such as ischemia.
The objective of the invention is to clearly propose the new medical usage of plant ketosteroid composition in the Radix Rhapontici, it is characterized in that osteoporosis is had significant therapeutical effect (to be comprised soreness of waist and knee joint, the improvement effect of symptoms such as muscles and bones is unable, and invigorating the liver and kidney, the strengthening by means of tonics effect of bone and muscle strengthening).The present invention makes in the Radix Rhapontici plant ketosteroid composition can expect to become new osteosporosis resistant medicament, and provides new approach for development and use Chinese medicine Radix Rhapontici.
The present invention finds through a large amount of chemistry and pharmaceutical research, the plant ketosteroid composition that separation obtains from Chinese medicine Radix Rhapontici [Rhaponticum uniflorum (L.) DC] has significant therapeutical effect to osteoporosis and (comprises soreness of waist and knee joint, the improvement effect of symptoms such as muscles and bones is unable, and invigorating the liver and kidney, the strengthening by means of tonics effect of bone and muscle strengthening).The pharmacodynamic experiment of system studies show that:
1, plant ketosteroid composition can increase the bone density of osteoporosis rat in the Radix Rhapontici; Increase the thickness and the bone trabecular width of osteoporosis rat cortical bone, the biomechanics index to the osteoporosis rat bone also improves significantly simultaneously;
2, plant ketosteroid composition has significant bone resorption inhibition activity in the Radix Rhapontici;
3, plant ketosteroid composition has the anabolic effect of tangible promotion chondrocyte DNA in the Radix Rhapontici.
The objective of the invention is to be achieved by the following scheme, plant ketosteroid composition is as the application of preparation treatment osteoporosis agents in the Radix Rhapontici, also can be used as the application that the preparation bone resorption suppresses active and promotes chondrocyte DNA medicine, also can be used as the application of preparation nootropic effect, antioxidation medicine.In the above-mentioned application in the Radix Rhapontici plant ketosteroid composition can be used for various dosage forms.
Advantage of the present invention is: the present invention finds that the plant ketosteroid composition that obtains has significant therapeutical effect to osteoporosis from the Chinese medicine Radix Rhapontici, especially find in the Radix Rhapontici that plant ketosteroid composition can suppress significantly that retinoic acid causes male rat and the bilateral ovaries enucleation causes the osteoporotic generation of female rats, simultaneously, experimentation shows that plant ketosteroid composition has the anabolic effect that significant bone resorption suppresses active and promotes chondrocyte DNA in the Radix Rhapontici.Point out it to bring into play therapeutical effect by number of ways, this is one of characteristic of the present invention.Recent research proves that also plant ketosteroid composition also has stronger nootropic effect, antioxidation in the Radix Rhapontici, helps protecting normal physiological function of organism, and this is two of a characteristic of the present invention.
In addition, this product toxicity is lower, in application dose and drug metabolism study process, does not see the toxic reaction that produces animal, is suitable for medical usage.
The present invention is described in further detail below in conjunction with embodiment.The present invention is not limited by embodiment.
Plant ketosteroid composition (RE) bone resorption suppresses active in embodiment 1, the Radix Rhapontici
Table 1 rhapontisterone Punisterone constituents (RE) resists into influence to the bone resorption due to the PTH
| Sample | dose | n | 45Ca release(％) |
| RE+PTH RE+PTH RE+PTH PTH Control | 5μg/ml 50μg/ml 500μg/ml 2×10 -9M | 8 8 8 10 10 | 50.98±4.23 * 34.53±3.08 *** 31.84±3.32 *** 60.76±3.1### 30.63±3.27 |
*p＜0.05，
**p＜0.01，
***p＞0.001
The result shows: plant ketosteroid composition (RE) can suppress the mice skull due to the PTH significantly in the Radix Rhapontici
45C discharges hyperfunction.
Plant ketosteroid composition (RE) has obvious facilitation to the DNA of quiescent centre chondrocyte synthetic in embodiment 2, the Radix Rhapontici, the results are shown in Table 2.
Table 2 rhapontisterone Punisterone constituents (RE) is to the synthetic effect of the DNA of quiescent centre chondrocyte
| Sample | dose | n | 3H activity in DNA(cpm) |
| RE RE RE RE Control | 1μg/ml 10μg/ml 100μg/ml 500μg/ml | 6 6 6 6 10 | 1287±209 1593±331 ** 2211±248 *** 1612±281 ** 1134±203 |
*p＜0.05，
**p＜0.01，
***p＜0.001
Plant ketosteroid composition (RE) causes the influence of male osteoporosis rats with left tibial bone density (BMD) in embodiment 3, the Radix Rhapontici to retinoic acid
Plant ketosteroid composition (RE) the results are shown in Table 3 to the influence of osteoporosis rat left side tibial bone density (BMD) in the Radix Rhapontici.The bone density of model group male rat (BMD) obviously descends (P＜0.01) than normal group, and tibial bone density is reduced to 88.76% of normal group.The BMD of plant ketosteroid composition (RE) treatment group all has recovery in various degree in each Radix Rhapontici, though still be lower than the normal group no difference of science of statistics.
Table 3 rhapontisterone Punisterone constituents (RE) causes the influence of male osteoporosis rats with left tibial bone density (BMD) to retinoic acid
| Groups | Dosage | case | BMD |
| Normal control group Model group XLD RE RE RE | ----- ----- 250mg/kg/d 50mg/kg/d 100mg/kg/d 200mg/kg/d | 10 10 10 10 10 10 | 0.389±0.011 0.305±0.019 ** 0.354±0.021## 0.331±0.016# 0.357±0.013## 0.353±0.010## |
Compared to normal control
*p＜0.05
**p＜0.01
Compared to model #p＜0.05 ##p＜0.01
Plant ketosteroid composition (RE) causes the influence of female osteoporosis rat left side tibial bone density (BMD) in embodiment 4, the Radix Rhapontici to the bilateral ovaries enucleation.
As shown in table 4, the BMD of model group female rats compares obvious decline (p＜0.01) with normal group.Through give with Radix Rhapontici in plant ketosteroid composition (RE) treatment after, the BMD of each treatment group all has recovery in various degree.As seen the plant ketosteroid composition in the Radix Rhapontici can improve the bone density of female osteoporosis rat, and certain dose-effect relationship is arranged.
Table 4 rhapontisterone Punisterone constituents (RE) causes the influence of female rats left side tibial bone density (BMD) to the bilateral ovaries enucleation
| Groups | Dosage | case | BMD(g/cm 2) |
| Normal control group Model group XLD Active fraction Active fraction Active fraction | —— —— 250mg/kg/d 50mg/kg/d 100mg/kg/d 200mg/kg/d | 10 10 10 10 10 10 | 0.352±0.016 0.323±0.013 ** 0.349±0.019# 0.348±0.022# 0.359±0.026## 0.357±0.021## |
Compared to normal control
*p＜0.05
**p＜0.01
Compared to model #p＜0.05 ##p＜0.01
Claims (2)
1, the purposes of plant ketosteroid composition in the Chinese medicine Radix Rhapontici is characterized in that: plant ketosteroid composition also can be used as the application that the preparation bone resorption suppresses active and promotes chondrocyte DNA synthetic drug as the application of preparation treatment osteoporosis agents in the Radix Rhapontici.
2, the purposes of plant ketosteroid composition in the Chinese medicine Radix Rhapontici according to claim 1, it is characterized in that: plant ketosteroid composition can be used for various dosage forms in the described Chinese medicine Radix Rhapontici.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00110672 CN1274319C (en) | 2000-07-18 | 2000-07-18 | Medical use of phytosterone component in Radix Rhapontici |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00110672 CN1274319C (en) | 2000-07-18 | 2000-07-18 | Medical use of phytosterone component in Radix Rhapontici |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1334093A CN1334093A (en) | 2002-02-06 |
| CN1274319C true CN1274319C (en) | 2006-09-13 |
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| CN 00110672 Expired - Fee Related CN1274319C (en) | 2000-07-18 | 2000-07-18 | Medical use of phytosterone component in Radix Rhapontici |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2390270C1 (en) * | 2009-03-13 | 2010-05-27 | Общество С Ограниченной Ответственностью "Парафарм" | Dietary supplement |
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Granted publication date: 20060913 |