CN1274304C - Etomidate fatty emulsion injection preparation method - Google Patents
Etomidate fatty emulsion injection preparation method Download PDFInfo
- Publication number
- CN1274304C CN1274304C CN 02112797 CN02112797A CN1274304C CN 1274304 C CN1274304 C CN 1274304C CN 02112797 CN02112797 CN 02112797 CN 02112797 A CN02112797 A CN 02112797A CN 1274304 C CN1274304 C CN 1274304C
- Authority
- CN
- China
- Prior art keywords
- etomidate
- preparation
- fatty emulsion
- emulsion injection
- colostrum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NPUKDXXFDDZOKR-LLVKDONJSA-N etomidate Chemical compound CCOC(=O)C1=CN=CN1[C@H](C)C1=CC=CC=C1 NPUKDXXFDDZOKR-LLVKDONJSA-N 0.000 title claims abstract description 22
- 229960001690 etomidate Drugs 0.000 title claims abstract description 22
- 238000002347 injection Methods 0.000 title claims abstract description 18
- 239000007924 injection Substances 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000000839 emulsion Substances 0.000 title claims abstract description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 210000003022 colostrum Anatomy 0.000 claims abstract description 10
- 235000021277 colostrum Nutrition 0.000 claims abstract description 10
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000000787 lecithin Substances 0.000 claims abstract description 8
- 229940067606 lecithin Drugs 0.000 claims abstract description 8
- 235000010445 lecithin Nutrition 0.000 claims abstract description 8
- 239000003921 oil Substances 0.000 claims abstract description 8
- 235000019198 oils Nutrition 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims abstract description 7
- 239000003708 ampul Substances 0.000 claims abstract description 6
- 235000012424 soybean oil Nutrition 0.000 claims abstract description 6
- 239000003549 soybean oil Substances 0.000 claims abstract description 6
- 239000008215 water for injection Substances 0.000 claims abstract description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 4
- 238000007789 sealing Methods 0.000 claims abstract description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 239000012528 membrane Substances 0.000 claims description 6
- 239000012071 phase Substances 0.000 claims description 6
- 102000002322 Egg Proteins Human genes 0.000 claims description 5
- 108010000912 Egg Proteins Proteins 0.000 claims description 5
- 241000287828 Gallus gallus Species 0.000 claims description 5
- 239000012982 microporous membrane Substances 0.000 claims description 5
- 210000004681 ovum Anatomy 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- 239000008346 aqueous phase Substances 0.000 claims description 3
- 239000000243 solution Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 239000011259 mixed solution Substances 0.000 abstract 3
- 230000002349 favourable effect Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000009775 high-speed stirring Methods 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 4
- 230000002950 deficient Effects 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010022086 Injection site pain Diseases 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- IUJDSEJGGMCXSG-UHFFFAOYSA-N Thiopental Chemical compound CCCC(C)C1(CC)C(=O)NC(=S)NC1=O IUJDSEJGGMCXSG-UHFFFAOYSA-N 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 229960000796 barbital sodium Drugs 0.000 description 1
- FTOAOBMCPZCFFF-UHFFFAOYSA-N barbitone sodium Natural products CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 1
- 229940125717 barbiturate Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- -1 fatty acid triglycerides Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000002695 general anesthesia Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000002960 lipid emulsion Substances 0.000 description 1
- 150000004667 medium chain fatty acids Chemical class 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000019989 milk ejection Effects 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 208000001297 phlebitis Diseases 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- RGHFKWPGWBFQLN-UHFFFAOYSA-M sodium;5,5-diethylpyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].CCC1(CC)C([O-])=NC(=O)NC1=O RGHFKWPGWBFQLN-UHFFFAOYSA-M 0.000 description 1
- 201000005060 thrombophlebitis Diseases 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 02112797 CN1274304C (en) | 2002-03-25 | 2002-03-25 | Etomidate fatty emulsion injection preparation method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 02112797 CN1274304C (en) | 2002-03-25 | 2002-03-25 | Etomidate fatty emulsion injection preparation method |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1399959A CN1399959A (en) | 2003-03-05 |
CN1274304C true CN1274304C (en) | 2006-09-13 |
Family
ID=4742261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 02112797 Expired - Lifetime CN1274304C (en) | 2002-03-25 | 2002-03-25 | Etomidate fatty emulsion injection preparation method |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1274304C (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100386085C (en) * | 2003-12-17 | 2008-05-07 | 昆明紫健生物技术有限公司 | Fat Emulsion transfusion liquid for preventing and curing tumour and production method thereof |
CN100386082C (en) * | 2005-12-22 | 2008-05-07 | 济南百诺医药科技开发有限公司 | Oryzanol composition and its preparation method |
CN101904814A (en) | 2009-06-04 | 2010-12-08 | 上海恒瑞医药有限公司 | Preparation method of drug loaded emulsion |
CN102579433A (en) * | 2011-01-14 | 2012-07-18 | 海南际中博远实业发展有限公司 | Application of etomidate to preparation of medicament for preventing or treating posttraumatic stress disorder |
CN103768055B (en) * | 2012-10-26 | 2015-11-25 | 上海医药工业研究院 | Injection etomidate composition and method of making the same |
CN103961314A (en) * | 2013-01-24 | 2014-08-06 | 上海医药工业研究院 | Stable anesthetic emulsion |
CN104706587A (en) * | 2013-12-16 | 2015-06-17 | 天津迈迪瑞康生物医药科技有限公司 | Etomidate fat emulsion concentrated solution, preparation method and application thereof |
CN104569264B (en) * | 2014-12-30 | 2016-05-18 | 李宏 | A kind of assay method of Etomidate related substance |
CN104644554B (en) * | 2015-03-05 | 2018-03-16 | 北京蓝丹医药科技有限公司 | A kind of Etomidate pharmaceutical composition and preparation method thereof |
CN105055310B (en) * | 2015-08-30 | 2018-03-09 | 四川百利药业有限责任公司 | A kind of injection Etomidate composition and preparation method thereof |
CN107049967A (en) * | 2016-12-31 | 2017-08-18 | 辰欣药业股份有限公司 | A kind of Etomidate freeze-dried emulsion and preparation method thereof |
CN110860252A (en) * | 2019-12-19 | 2020-03-06 | 宁波和信制药设备有限公司 | Stirring device applied to fat emulsion preparation system and mixing method |
-
2002
- 2002-03-25 CN CN 02112797 patent/CN1274304C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1399959A (en) | 2003-03-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: JIANGSU ENHUA PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: XUZHOU YIHUA MEDICINE SCIENCE AND TECHNOLOGY CO., LTD. Effective date: 20070727 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20070727 Address after: 221007 No. 289, Zhongshan North Road, Jiangsu, Xuzhou Patentee after: Jiangsu Nhwa Pharmaceutical Co., Ltd. Address before: 221007 extension of Xuzhou, Jiangsu, Zhongshan North Road Patentee before: Yihua Medicinal Science and Technology Co., Ltd., Xuzhou |
|
C56 | Change in the name or address of the patentee | ||
CP02 | Change in the address of a patent holder |
Address after: 221007 No. 18 Yang Shan Road, Xuzhou Economic Development Zone, Jiangsu, China Patentee after: Jiangsu Nhwa Pharmaceutical Co., Ltd. Address before: 221007 Zhongshan North Road, Jiangsu, No. 289, Patentee before: Jiangsu Nhwa Pharmaceutical Co., Ltd. |
|
CX01 | Expiry of patent term |
Granted publication date: 20060913 |
|
CX01 | Expiry of patent term |