CN1269785C - Process for preparing aldehyde ketone and acid by oxidation of olefin - Google Patents
Process for preparing aldehyde ketone and acid by oxidation of olefin Download PDFInfo
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- CN1269785C CN1269785C CN 200410046719 CN200410046719A CN1269785C CN 1269785 C CN1269785 C CN 1269785C CN 200410046719 CN200410046719 CN 200410046719 CN 200410046719 A CN200410046719 A CN 200410046719A CN 1269785 C CN1269785 C CN 1269785C
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- general formula
- oxygen
- aldehyde
- ketone
- olefin
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Abstract
The present invention discloses a method for preparing aldehyde, ketone and acid by olefin oxidization. In the presence of air or oxygen or mixed gas of oxygen and inert gases or other chemical oxidants, the oxidant is added into solvent, the control pressure is controlled between 0.1 and 1.8MPa, the temperature is from 60 to 180DEGC, monometallic porphyrin with the general formula (I) or mu-oxygen bimetallic porphyrin with the general formula (II) is used as a catalyst, the catalyst concentration is from 1 to 100PPM, and the reaction time is from 0.5 to 5 hours. In the presence of the air or the oxygen or the mixed gas of oxygen ad inert gases or the chemical oxidants, the oxidant is not added into the solvent, the reaction pressure is controlled between 1 and 1.8MPa, the temperature is from 160 to 180DEGC, the monometallic porphyrin with the general formula (I) or the mu-oxygen bimetallic porphyrin with the general formula (II) is used as the catalyst, the catalyst concentration is from 51 to 100PPM, and the reaction time is from 0.5 to 5 hours. The method has the advantages of good selectivity, high conversion rate and recovery rate, avoidance of the generation of deep oxidation products, high product purity and easy separation.
Description
Technical field
The present invention relates to the method that a kind of olefin oxidation prepares aldehyde, ketone, acid, especially relate to a kind of under catalysis of metalloporphyrin the selected oxidation of alkene prepare the method for aldehyde, ketone, acid.
Background technology
The complete oxidation of olefinic double bonds can prepare carboxylic acid and aldehyde, ketone.But the oxidizing reaction of alkene is poor to the reaction preference of carbon-carbon double bond, causes side reaction many, and product is difficult to be separated, and reaction yield is not high.Therefore, the chemical oxidation of alkene is uncontrollable and utilize owing to there is more deep oxidation product to generate, and it is then more difficult especially to obtain the reaction of product aldehyde from the controlled oxidation of alkene.Though alkene is at O
3Effect can obtain aldehyde from the complete oxidation of alkene through reductive hydrolysis down again, but because a large amount of reductive agents of this arts demand consumption and O
3, production cost is higher.The Chinese invention patent application discloses a kind of use metalloporphyrin for No. 200310110533.7 and has made catalyzer, and air is as oxygenant, under the situation of solvent-free existence, and the method for olefin oxide and cycloolefin, but this method can only obtain epoxide.
Summary of the invention
The purpose of this invention is to provide that a kind of selectivity is good, transformation efficiency and rate of recovery height, the generation that can avoid the deep oxidation product, product purity height, the segregative method that makes the alkene selective oxidation prepare aldehyde, ketone, acid.
The objective of the invention is to adopt following technical proposals to realize: oxygenant be the mixed gas of air or oxygen or oxygen and rare gas element or other chemical oxidizing agent in the presence of, at water, methyl alcohol, acetate, ethyl acetate, benzene, toluene, in the oil of mirbane equal solvent, the control reaction pressure is 0.1-1.8MPa, and temperature is under the 60-180 ℃ of temperature condition, selects for use by the monometallic porphyrin of general formula (I) or the μ-oxygen bimetallic porphyrin of general formula (II) and makes catalyzer, catalyst concn is 1-100PPM, reacts 0.5-5 hour.
Purpose of the present invention can also adopt following technical proposals to realize: oxygenant be the mixed gas of air or oxygen or oxygen and rare gas element or other chemical oxidizing agent in the presence of, under the situation of solvent-free existence, the control reaction pressure is 1-1.8MPa, temperature is under the condition of 160-180 ℃ of temperature, select for use by the monometallic porphyrin of general formula (I) or the μ-oxygen bimetallic porphyrin of general formula (II) and make catalyzer, catalyst concn is 51-100PPM, reacts 0.5-5 hour.
General formula (I)
General formula (II)
Atoms metal M in the general formula (I) can be transition metal atoms or lanthanide series metal atom, for example, and Fe, Mn, Co, Cr, Cu, Pt, Pd or Tb etc.; Substituent R on the phenyl ring
1, R
2, R
3Can be hydrogen, alkyl, alkoxyl group, hydroxyl, nitro, halogen, amido, amino, glycosyl replaces glycosyl or cyclodextrin; Dentate be can with atoms metal coordinate atom or atomic group, acetate for example, methyl ethyl diketone or halogen etc.
Atoms metal M in the general formula (II)
1, M
2Can be transition metal atoms, Fe for example, Mn or Cr etc.; Substituent R on the phenyl ring
1, R
2, R
3Can be hydrogen, alkyl, alkoxyl group, hydroxyl, nitro, halogen, amido, amino, glycosyl or cyclodextrin.
Alkene can be alkene, cycloolefin, polycyclic olefin among the present invention, fragrant alkene or their derivative.
Described chemical oxidizing agent can be NaClO, H
2O
2Or Peracetic Acid.
The solvent that uses among the present invention can be a water, methyl alcohol, acetate, ethyl acetate, benzene, toluene or oil of mirbane etc.
The catalyzer that the present invention selects for use also can be above-mentioned metalloporphyrin and supported metalloporphyrin inorganic or that organic polymer material constitutes.
The carrier that constitutes the supported metalloporphyrin catalyzer with above-mentioned metalloporphyrin has: silica gel, molecular sieve, aluminum oxide, zeolite, diatomite, activated carbon, sepiolite, porous ceramics, polyvinyl chloride, polyvinyl chloride, polystyrene, Mierocrystalline cellulose, chitosan, chitin or their modifier.
Selectivity of the present invention is good, and aldehyde, ketone, sour transformation efficiency and rate of recovery height can be avoided the generation of deep oxidation product, the product purity height, and separate easily, production cost is low.
Embodiment
Embodiment 1
5mg had the metalloporphyrin of structural formula (I), R
1=CH
3, R
2=cyclodextrin, R
3=H, M=Mn, X=acetate adds in 50ml 3-phenylacrolein and the 300ml benzene, feeds the 0.4MPa air.120 ℃ of following reaction stirred 3 hours, 3-phenylacrolein transformation efficiency was 85%, phenyl aldehyde yield 50% in the reaction product, phenylformic acid yield 15%.
Embodiment 2
5mg had the metalloporphyrin of structural formula (II), R
1=R
2=OH, R
3=Cl, M
1=M
2=Fe adds in 200ml vinylbenzene and the 200ml oil of mirbane, feeds the 1.4MPa air.90 ℃ of following reaction stirred 4 hours, the styrene conversion rate was 78%, phenyl aldehyde yield 45% in the reaction product, phenylformic acid yield 20%.
Embodiment 3
The immobilized 3mg of chitosan is had the metalloporphyrin of structural formula (I), R1=OCH3, R2=R3=H, M=Co, X=Br adds 100ml 2, in 3-phenylbenzene-2-butylene and the 300ml toluene, feeds the oxygen-denuded air that 1.2MPa contains oxygen 15% (v/v).140 ℃ of following reaction stirred 2 hours, 2,3-phenylbenzene-2-butylene transformation efficiency is 80.8%, methyl phenyl ketone yield 65% in the reaction product.
Embodiment 4
With the metalloporphyrin of the immobilized 2mg structural formula of molecular sieve (II), R
1=NO
2, R
2=R
3=H, M
1=Cr, M
2=Mn adds in the 200ml α-Pai Xi.Slowly add the aqueous solution 300ml that contains 80 gram NaClO under 70 ℃ of stirrings, reacted 2 hours, the α-Pai Xi transformation efficiency is 50.3%, the yield 45% of reaction product aldehyde and acid, the selectivity 63% of aldehyde.
Embodiment 5:
With the metalloporphyrin of the immobilized 10mg structural formula of polyvinyl chloride (I), R
1=R
2=N (CH3)
2, R
3=C
2H
5, M=Tb, X=Cl adds in 150ml tetrahydrobenzene and the 200ml acetate.Feed 1.6MPa oxygen.160 ℃ of following reaction stirred 1 hour, the tetrahydrobenzene transformation efficiency was 46%, hexanedial yield 30% in the reaction product.
Embodiment 6:
5mg had the metalloporphyrin of structural formula (I), R
1=C
4H
9, R
2=R
3=H, M=Cu, X=F adds in the mixed system of 300ml 9-eicosenoic acid and 100ml ethyl acetate, feeds the oxygen-rich air that 0.7MPa contains oxygen 25%.130 ℃ of following reaction stirred 2 hours, 9-eicosenoic acid transformation efficiency was 67.5%, aldehyde, sour yield 52% in the reaction product, the selectivity 65% of aldehyde.
Embodiment 7:
With the metalloporphyrin that 3mg has general formula (I) structure, R
1=R
2=H, R
3=Cl, M=Pt, X=Cl, with the fine little element of 3 grams immobilized after, add in the 500ml cyclonene, feed the mixing air that 1.7MPa contains 2%CO.165 ℃ of following reaction stirred 0.5 hour, the cyclonene transformation efficiency was 20.5%, aldehyde, sour yield 16% in the reaction product, the yield 73% of acid.
Embodiment 8:
With the metalloporphyrin that 3mg has general formula (I) structure, R
1=R
2=H, R
3=2,3,4,6-tetrem acyl glucosyl group, M=Fe, X=Cl adds in 200ml benzo cyclopentenes and the 200ml water, feeds the 0.6MPa air.Reacted 1 hour down at 120 ℃, benzo cyclopentenes transformation efficiency is 35%, substituted benzene dialdehyde yield 27% in the reaction product.
Embodiment 9:
8mg had the metalloporphyrin of general formula (I), R
1=OC
2H
5, R
2=NH
2, R
3=H, M=Cr X=Cl adds in 100ml phenylallene and the 100ml methyl alcohol, slowly adds 200 gram 40%H under the stirring down at 130 ℃
2O
2, reacting 2.5 hours, the phenylallene transformation efficiency is 72.4%, phenyl aldehyde yield 50% in the reaction product.
Embodiment 10:
6mg had the metalloporphyrin of general formula (I), R
1=Br, R
2=R
3=H, M=Pd, X=Cl, with 5 gram diatomite immobilized after, add in the 500ml suberene, feed the 1.6MPa air.165 ℃ of following reaction stirred 3 hours, the suberene transformation efficiency was 80.5%, in the reaction product heptan dialdehyde yield 60%, pimelic acid yield 12%.
Claims (9)
1, a kind of olefin oxidation prepares the method for aldehyde, ketone, acid, it is characterized in that, at oxygenant is in the presence of the mixed gas of air or oxygen or oxygen and rare gas element, in water, methyl alcohol, acetate, ethyl acetate, benzene, toluene or oil of mirbane solvent, the control reaction pressure is 0.1-1.8MPa, temperature is under the 60-180 ℃ of temperature condition, select for use by the monometallic porphyrin of general formula (I) or the μ-oxygen bimetallic porphyrin of general formula (II) and make catalyzer, catalyst concn is 1-100PPM, reacts 0.5-5 hour;
General formula (I)
General formula (II)
Atoms metal M in the general formula (I) is transition metal atoms or lanthanide series metal atom; Substituent R on the phenyl ring
1, R
2, R
3Be hydrogen, alkyl, alkoxyl group, hydroxyl, nitro, halogen, amido, amino, glycosyl or cyclodextrin; Dentate X be can with atoms metal coordinate atom or atomic group;
Atoms metal M in the general formula (II)
1, M
2Be transition metal atoms; Substituent R on the phenyl ring
1, R
2, R
3Be hydrogen, alkyl, alkoxyl group, hydroxyl, nitro, halogen, amido, amino, glycosyl or cyclodextrin.
2, prepare the method for aldehyde, ketone, acid according to the described olefin oxidation of claim 1, it is characterized in that the atoms metal M in the described general formula (I) is Fe, Mn, Co, Cr, Cu, Pt, Pd or Tb; Dentate X is acetate, methyl ethyl diketone or halogen;
Atoms metal M in the described general formula (II)
1, M
2Be Fe, Mn or Cr.
3, prepare the method for aldehyde, ketone, acid according to claim 1 or 2 described olefin oxidations, it is characterized in that described reaction pressure is 0.6-1MPa, temperature of reaction is 100-140 ℃.
4, prepare the method for aldehyde, ketone, acid according to claim 1 or 2 described olefin oxidations, it is characterized in that described alkene is alkene, cycloolefin, polycyclic olefin, fragrant alkene or their derivative.
5, prepare the method for aldehyde, ketone, acid according to claim 1 or 2 described olefin oxidations, it is characterized in that described metalloporphyrin is the supported metalloporphyrin that constitutes with following carrier: silica gel, molecular sieve, aluminum oxide, zeolite, diatomite, activated carbon, sepiolite, porous ceramics, polyvinyl chloride, polyvinyl chloride, polystyrene, Mierocrystalline cellulose, chitosan, chitin or their modifier.
6, a kind of olefin oxidation prepares the method for aldehyde, ketone, acid, it is characterized in that, and at oxygenant mixed gas or chemical oxidizing agent NaClO, the H of air or oxygen or oxygen and rare gas element
2O
2, or Peracetic Acid exist down, the control reaction pressure is 1-1.8MPa, and temperature is under the 160-180 ℃ of temperature condition, selects for use by the monometallic porphyrin of general formula (I) or the μ-oxygen bimetallic porphyrin of general formula (II) and makes catalyzer, catalyst concn is 51-100PPM, reacts 0.5-5 hour;
Described general formula (I) and general formula (II) are respectively:
General formula (I)
General formula (II)
Atoms metal M in the general formula (I) is transition metal atoms or lanthanide series metal atom; Substituent R on the phenyl ring
1, R
2, R
3Be hydrogen, alkyl, alkoxyl group, hydroxyl, nitro, halogen, amido, amino, glycosyl or cyclodextrin; Dentate X be can with atoms metal coordinate atom or atomic group;
Atoms metal M in the general formula (II)
1, M
2Be transition metal atoms; Substituent R on the phenyl ring
1, R
2, R
3Be hydrogen, alkyl, alkoxyl group, hydroxyl, nitro, halogen, amido, amino, glycosyl or cyclodextrin.
7, prepare aldehyde, ketone, sour method according to the described olefin oxidation of claim 6, it is characterized in that, the atoms metal M in the described general formula (I) is Fe, Mn, Co, Cr, Cu, Pt, Pd or Tb; Dentate X is acetate, methyl ethyl diketone or halogen;
Atoms metal M in the described general formula (II)
1, M
2Be Fe, Mn or Cr.
8, prepare aldehyde, ketone, sour method according to claim 6 or 7 described olefin oxidations, it is characterized in that described alkene is alkene, cycloolefin, polycyclic olefin, fragrant alkene or their derivative.
9, prepare aldehyde, ketone, sour method according to claim 6 or 7 described olefin oxidations, it is characterized in that described metalloporphyrin is the supported metalloporphyrin that constitutes with following carrier: silica gel, molecular sieve, aluminum oxide, zeolite, diatomite, activated carbon, sepiolite, porous ceramics, polyvinyl chloride, polyvinyl chloride, polystyrene, Mierocrystalline cellulose, chitosan, chitin or their modifier.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410046719 CN1269785C (en) | 2004-09-02 | 2004-09-02 | Process for preparing aldehyde ketone and acid by oxidation of olefin |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410046719 CN1269785C (en) | 2004-09-02 | 2004-09-02 | Process for preparing aldehyde ketone and acid by oxidation of olefin |
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|---|---|
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| CN1269785C true CN1269785C (en) | 2006-08-16 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100379715C (en) * | 2006-04-11 | 2008-04-09 | 湖南大学 | Process for preparation of carboxylic acid esters |
| CN100386300C (en) * | 2006-05-19 | 2008-05-07 | 湖南大学 | Method for preparing alpha-olefine acid by olefin oxidation |
| CN101148406B (en) * | 2007-11-02 | 2011-04-20 | 中国科学院过程工程研究所 | Method for preparing carboxylic acid ester by using aldehyde, alcohol and oxidizing agent as raw material |
| AT506983B1 (en) * | 2008-07-09 | 2011-11-15 | Univ Graz | Heme COMPLEX |
| CN105669598B (en) * | 2016-01-12 | 2018-06-29 | 中国林业科学研究院林产化学工业研究所 | A kind of australene allylic process for selective oxidation and products thereof |
| CN111138253B (en) * | 2019-12-16 | 2021-06-22 | 中国科学院大连化学物理研究所 | Cyclohexene oxide process |
| CN111056955B (en) * | 2019-12-16 | 2021-05-25 | 中国科学院大连化学物理研究所 | Method for preparing hexamethylene diamine from cyclohexene |
| CN115160115B (en) * | 2022-08-03 | 2024-02-27 | 中山大学 | Method for preparing acetone by biomimetic catalysis of isobutene |
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