CN1264562C - Chinese medicine drippling pill for treating coronary heart disease and its preparing method - Google Patents
Chinese medicine drippling pill for treating coronary heart disease and its preparing method Download PDFInfo
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- CN1264562C CN1264562C CN 200410074773 CN200410074773A CN1264562C CN 1264562 C CN1264562 C CN 1264562C CN 200410074773 CN200410074773 CN 200410074773 CN 200410074773 A CN200410074773 A CN 200410074773A CN 1264562 C CN1264562 C CN 1264562C
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Abstract
The present invention discloses a Chinese medicine dripping pill for treating coronary disease and a preparation method thereof. The Chinese medicine dripping pill is characterized in that the dripping pill is formed by compounding 17 to 24 weight portions of extracts extracted from traditional Chinese medicine such as sandalwood, lignum dalbergiae odoriferae, kaempferiae, nutmeg, red sage root, axillary choerospondias fruit and hippophae rhamnoides, and 17 to 24 weight portions of medicinal auxiliary materials, wherein the content of volatile oil in the extracts is 2 to 2.5%. The Chinese medicine dripping pill is also characterized in that the content of tanshinone II A in the dripping pill is required to be higher than or equal to 1.0 mg/g, and the content of total phenolic acid of the red sage roots is required to be higher than or equal to 14 mg/g. The dripping pill of the present invention has better pharmacological action by the indication of results of pharmacological experiments.
Description
Affiliated technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of drop pill and preparation method thereof with the effect of treatment coronary heart disease.
Background technology
Coronary heart disease is the abbreviation of coronary heart disease.Be a kind of because coronary artery stationarity (atheroma sclerosis) or dynamic property (vasospasm) stenosis or occlusion, the coronary circulation obstacle takes place, cause that myocardial oxygen is given and needs between unbalance and cause myocardial ischemia-anoxemia or downright bad a kind of heart disease, also claim ischemic heart desease.Evidence of coronary heart diseases increases with the growth at age, and degree also increases the weight of with the increase at age.There is data to show, from beginning in 40 years old, every increase by 10 years old, prevalence of coronary heart disease increases by 1 times.Male 50 years old, women are after 60 years old, and the coronary atherosclerosis development is rapider, and the danger of same myocardial infarction also increases along with the increase at age.Coronary heart disease is because its sickness rate height, the mortality rate height, serious harm human healthy, thereby b referred to as " the first human killer ".Coronary heart disease is obstinate why, is because the medicine of treatment was based on simple blood vessel dilating, blood flow increasing in the past, is difficult to solve root problem---the coronary atherosclerosis of coronary heart disease.
Ulan Wen Doushun-7 heart tablet of seven ingredients that wins again, it is the Mongolian medicinal preparation of making by Radix Salviae Miltiorrhizae, Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae, Semen Myristicae, Fructus Choerospondiatis, Fructus Hippophae seven flavor medicine, have blood circulation promoting and blood stasis dispelling, heart tonifying analgesic effect, cure mainly: coronary heart disease, angina pectoris, myocardial ischemia, arrhythmia, ventricular hypertrophy, myocardial infarction, heart failure, vexed cardiopalmus, sensation of oppression over the chest with shortness of breath, dyspnea etc.The effective ingredient of modern study proof coronary disease tablet of seven ingredients has special therapeutical effect to coronary atherosclerosis, and it can make the coronary atherosclerotic score piece gradate to be the normal blood vessels smooth muscle, thereby fundamentally solves the coronary atherosclerosis problem.The clinical coronary disease tablet of seven ingredients that shows is evident in efficacy to a series of symptoms that coronary heart disease and it cause.The general morbidity of coronary heart disease is hurried, and because the coronary disease tablet of seven ingredients is Chinese medicine half an extractum sheet, disintegration time is long in vivo, drug releasing rate is slow, and Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae, Semen Myristicae four flavors are directly pulverized and are used for preparation tablets, and its main effective ingredient is a volatile oil, owing to do not dissociate out, thereby effective ingredient in vivo stripping absorb slowlyer, be not enough to reach rapid alleviation coronary heart disease, anginal purpose.
Consult Patent data, do not retrieve relevant Patent data.
Summary of the invention
The object of the present invention is to provide a kind of Traditional Chinese Medicine Dropping Pill that is used for the treatment of coronary heart disease that can bring into play medicinal effects rapidly.
The present invention also aims to provide a kind of preparation method that is used for the treatment of the Chinese medicine dripping pills of coronary heart disease.
The present invention realizes by the following technical solutions:
Extract Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae, myristic main effective ingredient volatile oil, medicinal residues and Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and the Fructus Hippophae carried behind the oil are used alcohol reflux, get ethanol extract, medicinal residues after the alcohol extraction are extracting in water again, merge above water extract, alcohol extract, be condensed into dry extract, extract the dry extract and the volatile oil that obtain and join in the suitable substrate, be prepared into a kind of drop pill that is used for coronary heart disease treatment of the present invention with conventional dropping pill technique.
Zero, process recipes
1. crude drug prescription (weight portion) is:
Radix Salviae Miltiorrhizae 35-42, Lignum Santali Albi 3-5, Lignum Dalbergiae Odoriferae 7-10, Rhizoma Kaempferiae 5-8, Semen Myristicae 10-15, Fructus Choerospondiatis 10-15, Fructus Hippophae 10-15;
2. extraction process
1. Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae and Semen Myristicae are put in the extractor that has the volatile oil catcher, extracting in water 4-6 hour, collect volatile oil, the water extract filters, and concentrates.
2. Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and Fructus Hippophae add 95% soak with ethanol 5-7 hour, extract medicinal residues behind the volatile oil and Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and Fructus Hippophae with 95% ethanol extraction 2 times, each 1 hour.Filter, merging filtrate concentrates, and gets ethanol extract.
3. the medicinal residues after the alcohol extraction add water boil 2 times, each 1.5 hours, filter, filtrate concentrates, merge with the concentrated solution of carrying the water extract behind the oil, water extract.
4. merge above-mentioned ethanol extract, water extract, drying under reduced pressure gets dry extract.
3. drop pill preparation technology
The medicinal material extract dried cream powder is broken, cross 100 mesh sieves.Get PEG400 and add volatile oil, the ratio in PEG4000 and PEG400 (8: 2) adds PEG4000 then, and 80 ℃ of heating are stirred, fusing.The dried cream powder of weight such as adding stirs, and makes fusion.Under 80 ℃ of insulations, drip system.
A kind of Chinese medicine dripping pills crude drug optimizing prescriptions (weight portion) for the treatment of coronary heart disease of the present invention is:
Radix Salviae Miltiorrhizae 38-39, Lignum Santali Albi 4-4.5, Lignum Dalbergiae Odoriferae 8-9, Rhizoma Kaempferiae 6-7, Semen Myristicae 12-13.5, Fructus Choerospondiatis 12-13.5, Fructus Hippophae 12-13.5.
Consisting of of drop pill of the present invention: extract 17-24 weight portion, pharmaceutic adjuvant 17-24 weight portion; Wherein volatile oil accounts for the 2-2.5% of drug extract; Its feature is that also the content of tanshinone in the drop pill must not be lower than 1.0mg/g.Radix Salviae Miltiorrhizae total phenolic acids content must not be lower than 14mg/g.
Drop pill is to make with solid dispersion method, and dissolve scattered time limit is short, and the microgranule after molten the loosing is very little, is beneficial to absorption, and can passes through mucosa absorption, directly enters blood circulation, thus rapid-action, the bioavailability height of active component.Drop pill faces with before adding the promptly very fast molten liquid type that looses into of suitable quantity of water for the patient of dysphagia, and the patient of being convenient to dysphagia uses.
The present invention adopts the mode of drug extract and substrate congruent melting, medicine is dispersed in the substrate with molecularity, form solid solution, simultaneously in condensation process, medicine and substrate are separated out superfine crystallization simultaneously, form simple eutectic mixture, help absorbing, thereby improve bioavailability.Preparation of the present invention has efficient, quick-acting characteristics for diseases such as coronary heart disease, angina pectoriss, makes it to satisfy the requirement of treatment coronary heart disease first aid.Pharmacological evaluation proves that drop pill of the present invention has great pharmacological effects
Zero, check and analysis
The detection of Tanshinone I I A
Experimental apparatus: Waters high performance liquid chromatograph (600 pumps, 2487 detectors), Millinium32 chromatography software)
Chromatographic condition: YWG-C18 (4*150mm, 10 μ m) detects wavelength: 270nm, flow velocity: 0.9ml/min; Mobile phase: methanol-water (15: 5)
Experimental technique: get the methanol solution that tanshinone reference substance (Nat'l Pharmaceutical ﹠ Biological Products Control Institute) is made into 16 μ g/ml, other gets 30 in preparation, put in the 100ml volumetric flask and with dissolve with methanol and be settled to scale, the leaching supernatant is got reference substance solution and sample solution 5 μ l sample introduction and calculating respectively.The result as
Table 1
The assay of tanshinone in table 1 preparation
| Group | The content of tanshinone (mg/g) |
| Drop pill 1 drop pill 2 drop pill 3 of the present invention of the present invention of the present invention | 1.20 1.25 1.20 |
The mensuration of Radix Salviae Miltiorrhizae total phenolic acids
Experimental apparatus: Tianjin, island UV-3000 ultraviolet spectrophotometer
Experimental technique: get in protocatechualdehyde reference substance (Nat'l Pharmaceutical ﹠ Biological Products Control Institute) 1.5mg to the 10ml volumetric flask and be made into reference substance solution; get preparation 1g of the present invention and add that 1mol/l hydrochloric acid 10ml is ultrasonic to make dissolving; with extracted with diethyl ether 4 times; each 4ml; merge ether extracted liquid; water bath method, residue add the 1mol/l dissolving with hydrochloric acid and be settled to 100ml, sample liquid.Also calculate in the trap of 281nm working sample and contrast solution respectively.The results are shown in Table 2
The assay of Radix Salviae Miltiorrhizae total phenolic acids in table 2 preparation
| Group | The content of Radix Salviae Miltiorrhizae total phenolic acids (mg/g) |
| Drop pill 1 drop pill 2 drop pill 3 of the present invention of the present invention of the present invention | 18.25 20.10 17.07 |
Two, dissolution experiment
1. instrument and reagent: the full-automatic digestion instrument of SR-6 type (U.S. Hanson company); Distilled water (self-control); Coronary disease seven flavor drop pill (Qianluchun Science and Technology Co., Ltd., Beijing's laboratory provides); Coronary disease tablet of seven ingredients (covering pharmaceutical Co. Ltd in the Ulan Hot).
2. experimental technique: second method of pressing in the dissolution method (" 2000 editions two appendix XC of Chinese pharmacopoeia) is measured.
Each container fills the distilled water through degassing processing of 900ml, and heating makes water temperature remain on 37 ℃ ± 0.5 ℃, and rotating speed of agitator is 50 rev/mins.At following point in time sampling 5ml solution, centrifugal, supernatant is as need testing solution respectively.Use the high effective liquid chromatography for measuring tanshinone.The results are shown in Table 3.
The dissolution of two kinds of medicines of table 3 relatively
| The medicine group | (min) tanshinone sample time (mg) | |||||||||
| 1 | 2 | 4 | 8 | 12 | 16 | 20 | 30 | 45 | 60 | |
| Coronary disease tablet of seven ingredients coronary disease seven flavor drop pill | 0.012 0.011 | 0.017 0.027 | 0.033 0.051 | 0.051 0.052 | 0.086 0.052 | 0.127 0.052 | 0.168 0.052 | 0.212 | 0.310 | 0.311 |
Conclusion: as can be known by above result of the test, in tanshinone, the coronary disease tablet of seven ingredients in the time of 20 minutes dissolution rate only be 53.8%, and the stripping in 2 minutes of coronary disease of the present invention seven flavor drop pill promptly reaches 52%, stripping is complete substantially in the time of 4 minutes, proves absolutely that the external dissolution rate of coronary disease seven flavor drop pill of the present invention is very fast.Be beneficial to quick-acting effects are brought into play in coronary heart disease, angina pectoris.
Four, pharmacology embodiment
0. drop pill of the present invention is to atherosclerotic influence
Experiment medicine: coronary disease tablet of seven ingredients (covering pharmaceutical Co. Ltd in the Chinese Ulan Hot)
FUFANG DANSHEN DIWAN (sky, Tianjin Shi Li pharmaceutical Co. Ltd)
Coronary disease seven flavor drop pill (Qianluchun Science and Technology Co., Ltd., Beijing's laboratory provides) of the present invention
Distilled water (Qianluchun Science and Technology Co., Ltd., Beijing's laboratory provides)
Laboratory animal: Korea Carnis Coturnicis japonicae (male), body weight 100 ± 6g.
Experiment reagent: cholesterol (Nanjing biochemical-pharmaceutical factory), T-CHOL are measured medicine box, HDL-C, low-density lipoprotein cholesterol mensuration medicine box (Ningbo City's biochemical reagents company)
Experimental technique: select 50 of Carnis Coturnicis japonicaes for use, breeding observing is divided into 5 groups at random after one week, general food matched group, high fat matched group, GUANXIN QIYE PIAN agent group, drop pill group of the present invention, general food matched group is fed with normal diet, all the other each groups are fed with high lipid food, test group is administered once every day, and initial dosage is 0.67g crude drug/kg, 7 weeks of successive administration, weigh once every two weeks, to adjust dosage, broken end is got blood, separation of serum behind fasting at 7 weekends 15h, with enzymatic assays serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) separates high density lipoprotein (HDL) and inferior segmentation III (HDL with step sedimentation method
3), with enzymatic assays cholesterol level wherein, calculate C-VLDL (VLDL-C) and atherogenic index (AI) again.The results are shown in Table 4.
Table 4 pair atherosclerotic influence (mmol/l)
| Group | TC | TG | LDL-C | VLDL-C | HDL-C | AI |
| The high fat matched group of general food matched group FUFANG DANSHEN DIWAN coronary disease seven flavor drop pill coronary disease tablet of seven ingredients | 6.10±0.42 23.67±3.70** 8.19±1.42## 8.16±1.40## 8.20±1.11## | 1.33±0.22 2.64±0.53** 1.39±0.37## 1.40±0.45## 1.41±0.54## | 2.86±0.67 7.16±1.23** 3.10±0.56## 2.96±0.51## 3.20±0.65## | 0.61±0.32 14.36±3.39** 2.55±1.33## 2.56±0.95## 2.58±0.85## | 2.75±0.36 1.66±0.19** 2.55±0.34## 2.50±0.37## 2.53±0.33## | 1.26±0.38 13.44±3.07** 2.26±0.63## 2.24±0.67## 2.35±0.62## |
Annotate: * * and general food group be P＜0.01 relatively, and ## and high fat matched group be P relatively, and 0.01
Conclusion: above experimental result explanation, after testing for 7 weeks, high fat group Carnis Coturnicis japonicae serum TC, TG, LDL-C, VLDL-C, HDL-C and AI all significantly improve than general food matched group, and administration group Carnis Coturnicis japonicae serum TC, TG, LDL-C, VLDL-C, HDL-C and AI all significantly reduce than high fat matched group, illustrate that drop pill of the present invention has obvious improvement effect to atherosclerosis.
2. the present invention is to the influence of myocardial ischemia
Experiment medicine: coronary disease tablet of seven ingredients (covering pharmaceutical Co. Ltd in the Chinese Ulan Hot)
Coronary disease seven flavor drop pill (Qianluchun Science and Technology Co., Ltd., Beijing's laboratory provides) of the present invention
Distilled water (Qianluchun Science and Technology Co., Ltd., Beijing's laboratory provides)
Laboratory animal: mice, body weight 20 ± 2g.
Experimental technique: get 30 of mices, male and female half and half, be divided into 3 groups at random, experimental group gastric infusion dosage is 0.90g crude drug/kg (the administration volume is 0.5ml), matched group waits the dosage distilled water, respectively organizes mouse subcutaneous injection isoproterenol 10mg/kg in 10 minutes after the administration, puts into the 250ml wide mouthed bottle after 5 minutes immediately, the record mice time-to-live, the results are shown in Table 5
The anoxybiotic influence of table 5 pair scheming
| Group | Time-to-live (min) |
| Matched group coronary disease seven flavor drop pill coronary disease tablet of seven ingredients | 17.1±3.2 31.7±6.3* 25.4±5.7* |
Annotate: with matched group ratio, * p＜0.01
Conclusion: by experimental result as can be known, preparation of the present invention can improve the hypoxia-bearing capability of mice rapidly.Can obviously prolong time-to-live with the mice behind the isoproterenol.The anti-myocardial ischemia effect of the present invention is better than former tablet.
Five, preparation embodiment
Embodiment 1
(0) crude drug prescription proportioning is
Radix Salviae Miltiorrhizae 38.4g, Lignum Santali Albi 4.3g, Lignum Dalbergiae Odoriferae 8.5g, Rhizoma Kaempferiae 6.4g, Semen Myristicae 12.8g, Fructus Choerospondiatis 12.8g, Fructus Hippophae 12.8g.
(2) extraction process
1. with Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and Fructus Hippophae, put into extractor and add 95% ethanol 125ml, soaked 6 hours.
2. Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae and Semen Myristicae are put in the extractor that has the volatile oil catcher, are added water 250ml, extracted 5 hours, collect volatile oil 0.5ml.The water extract filters, and concentrates.
3. will extract medicinal residues and Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and Fructus Hippophae behind the volatile oil, with 95% ethanol extraction 2 times, each 1 hour.Filter, merging filtrate concentrates.
4. the medicinal residues after the alcohol extraction add water 250ml, water boil 2 times, and each 1.5 hours, filter, filtrate concentrates, with the concentrated solution merging of the water extract of carrying oil.
5. with the concentrated solution of said extracted, drying under reduced pressure, 21.7g gets dry extract.
(3) drop pill preparation technology
The medicinal material extract dried cream powder is broken, cross 100 mesh sieves.Get PEG400 and add volatile oil, the ratio in PEG4000 and PEG400 (8: 2) adds PEG4000 then, and 80 ℃ of heating are stirred, fusing.The dried cream powder of weight such as adding stirs, and makes fusion.Under 80 ℃ of insulations, be coolant with the dimethicone, drip internal diameter 4mm, coolant temperature 10-12 ℃, drip apart from 6cm, dripping speed is 50 droplets/minute, drips to make 1000.
Annotate: testing result: tanshinone 1.20mg/g, Radix Salviae Miltiorrhizae total phenolic acids 18.25mg/g.
Embodiment 2
(0) crude drug prescription proportioning is
Radix Salviae Miltiorrhizae 35g, Lignum Santali Albi 3g, Lignum Dalbergiae Odoriferae 7g, Rhizoma Kaempferiae 5g, Semen Myristicae 10g, Fructus Choerospondiatis 10g, Fructus Hippophae 10g.
(2) extraction process
1. with Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and Fructus Hippophae, put into extractor and add 95% ethanol 120ml, soaked 5 hours.
2. Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae and Semen Myristicae are put in the extractor that has the volatile oil catcher, are added water 230ml, extracted 4 o'clock, collect volatile oil 0.42ml.The water extract filters, and concentrates.
3. will extract medicinal residues and Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and Fructus Hippophae behind the volatile oil, with 95% ethanol extraction 2 times, each 1 hour.Filter, merging filtrate concentrates.
4. the medicinal residues after the alcohol extraction add water 230ml, water boil 2 times, and each 1.5 hours, filter, filtrate concentrates, with the concentrated solution merging of the water extract of carrying oil.
5. with the concentrated solution of said extracted, drying under reduced pressure, 17g gets dry extract.
(3) drop pill preparation technology
The medicinal material extract dried cream powder is broken, cross 100 mesh sieves.Get PEG400 and add volatile oil, the ratio in PEG4000 and PEG400 (8: 2) adds PEG4000 then, and 80 ℃ of heating are stirred, fusing.The dried cream powder of weight such as adding stirs, and makes fusion.Under 80 ℃ of insulations, be coolant with the dimethicone, drip internal diameter 4mm, coolant temperature 10-12 ℃, drip apart from 6cm, dripping speed is 50 droplets/minute, drips to make 1000.
Annotate: testing result: tanshinone 1.25mg/g, Radix Salviae Miltiorrhizae total phenolic acids 20.10mg/g.
Embodiment 3
(0) crude drug prescription proportioning is
Radix Salviae Miltiorrhizae 42g, Lignum Santali Albi 5g, Lignum Dalbergiae Odoriferae 10g, Rhizoma Kaempferiae 8g, Semen Myristicae 15g, Fructus Choerospondiatis 15g, Fructus Hippophae 15g.
(2) extraction process
1. with Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and Fructus Hippophae, put into extractor and add 95% ethanol 135ml, soaked 7 hours.
2. Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae and Semen Myristicae are put in the extractor that has the volatile oil catcher, are added water 275ml, extracted 6 hours, collect volatile oil 0.58ml.The water extract filters, and concentrates.
3. will extract medicinal residues and Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and Fructus Hippophae behind the volatile oil, with 95% ethanol extraction 2 times, each 1 hour.Filter, merging filtrate concentrates.
4. the medicinal residues after the alcohol extraction add water 275ml, water boil 2 times, and each 1.5 hours, filter, filtrate concentrates, with the concentrated solution merging of the water extract of carrying oil.
5. with the concentrated solution of said extracted, drying under reduced pressure, 23.8g gets dry extract.
(3) drop pill preparation technology
The medicinal material extract dried cream powder is broken, cross 100 mesh sieves.Get PEG400 and add volatile oil, the ratio in PEG4000 and PEG400 (8: 2) adds PEG4000 then, and 80 ℃ of heating are stirred, fusing.The dried cream powder of weight such as adding stirs, and makes fusion.Under 80 ℃ of insulations, be coolant with the dimethicone, drip internal diameter 4mm, coolant temperature 10-12 ℃, drip apart from 6cm, dripping speed is 50 droplets/minute, drips to make 1000.
Annotate: testing result: tanshinone 1.20mg/g, Radix Salviae Miltiorrhizae total phenolic acids 17.01mg/g.
Embodiment 4
(0) crude drug prescription proportioning is
Radix Salviae Miltiorrhizae 2310g Lignum Santali Albi 240g Lignum Dalbergiae Odoriferae 510g Rhizoma Kaempferiae 390g Semen Myristicae 750g Fructus Choerospondiatis 750g Fructus Hippophae 750g
(2) extraction process
1. with Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and Fructus Hippophae, put into extractor and add 95% ethanol 7800ml, soaked 6 hours.
2. Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae and Semen Myristicae are put in the extractor that has the volatile oil catcher, are added water 16000ml, extracted 4 o'clock, collect volatile oil 29.5ml.The water extract filters, and concentrates.
3. will extract medicinal residues and Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and Fructus Hippophae behind the volatile oil, with 95% ethanol extraction 2 times, each 1 hour.Filter, merging filtrate concentrates.
4. the medicinal residues after the alcohol extraction add water 16000ml, water boil 2 times, and each 1.5 hours, filter, filtrate concentrates, with the concentrated solution merging of the water extract of carrying oil.
5. with the concentrated solution of said extracted, drying under reduced pressure, 1440g gets dry extract
(3) drop pill preparation technology
The medicinal material extract dried cream powder is broken, cross 100 mesh sieves.Get PEG400 and add volatile oil, the ratio in PEG4000 and PEG400 (8: 2) adds PEG4000 then, and 80 ℃ of heating are stirred, fusing.The dried cream powder of weight such as adding stirs, and makes fusion.Under 80 ℃ of insulations, be coolant with the dimethicone, drip internal diameter 4mm, coolant temperature 10-12 ℃, drip apart from 6cm, dripping speed is 50 droplets/minute, drips system.
Annotate: testing result: tanshinone 1.19mg/g, Radix Salviae Miltiorrhizae total phenolic acids 17.56mg/g.
Embodiment 5
(0) crude drug prescription proportioning is
Radix Salviae Miltiorrhizae 2304g Lignum Santali Albi 256g Lignum Dalbergiae Odoriferae 512g Rhizoma Kaempferiae 384g Semen Myristicae 768g Fructus Choerospondiatis 768g Fructus Hippophae 768g
(2) extraction process
1. with Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and Fructus Hippophae, put into extractor and add 95% ethanol 7500ml, soaked 6 hours.
2. Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae and Semen Myristicae are put in the extractor that has the volatile oil catcher, added water 15000ml, extracted 5 hours, collect volatile oil 30.8ml.The water extract filters, and concentrates.
3. will extract medicinal residues and Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and Fructus Hippophae behind the volatile oil, with 95% ethanol extraction 2 times, each 1 hour.Filter, merging filtrate concentrates.
4. the medicinal residues after the alcohol extraction add water 15000ml, water boil 2 times, and each 1.5 hours, filter, filtrate concentrates, with the concentrated solution merging of the water extract of carrying oil.
5. with the concentrated solution of said extracted, drying under reduced pressure, 1390g gets dry extract.
(3) drop pill preparation technology
The medicinal material extract dried cream powder is broken, cross 100 mesh sieves.Get PEG400 and add volatile oil, the ratio in PEG4000 and PEG400 (8: 2) adds PEG4000 then, and 80 ℃ of heating are stirred, fusing.The dried cream powder of weight such as adding stirs, and makes fusion.Under 80 ℃ of insulations, be coolant with the dimethicone, drip internal diameter 4mm, coolant temperature 10-12 ℃, drip apart from 6cm, dripping speed is 50 droplets/minute, drips to make 60000.
Annotate: testing result: tanshinone 1.17mg/g, Radix Salviae Miltiorrhizae total phenolic acids 17.25mg/g.
Claims (2)
1. Chinese medicine dripping pills that is used for the treatment of coronary heart disease, the raw material medicines in portions by weight proportioning is: Radix Salviae Miltiorrhizae 35-42, Lignum Santali Albi 3-5, Lignum Dalbergiae Odoriferae 7-10, Rhizoma Kaempferiae 5-8, Semen Myristicae 10-15, Fructus Choerospondiatis 10-15, Fructus Hippophae 10-15 is characterized in that it is made by following method:
1. Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae and Semen Myristicae are put in the extractor that has the volatile oil catcher, extracting in water 4-6 hour, collect volatile oil, the water extract filters, and concentrates;
2. Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and Fructus Hippophae add 95% soak with ethanol 5-7 hour, extract medicinal residues and Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and Fructus Hippophae behind the volatile oil with 95% ethanol extraction 2 times, and each 1 hour, filter, merging filtrate, concentrated, must ethanol extract;
3. the medicinal residues after the alcohol extraction add water boil 2 times, each 1.5 hours, filter, filtrate concentrates, merge with the concentrated solution of carrying the water extract behind the oil, water extract;
4. merge above-mentioned ethanol extract, water extract, drying under reduced pressure gets dry extract;
The medicinal material extract dried cream powder is broken, cross 100 mesh sieves, get PEG400 and add volatile oil, be that 8: 2 ratios add PEG4000 in PEG4000 and PEG400 then, 80 ℃ of heating are stirred, fusing; The dried cream powder of weight such as adding stirs, and makes fusion, under 80 ℃ of insulations, is coolant with the dimethicone, drips system; The content of tanshinone is not less than 1.0mg/g in the drop pill, and Radix Salviae Miltiorrhizae total phenolic acids content is not less than 14mg/g.
2. the preparation method that is used for the treatment of the Chinese medicine dripping pills of coronary heart disease as claimed in claim 1 is characterized in that:
(1) crude drug prescription proportioning weight portion is: Radix Salviae Miltiorrhizae 35-42, Lignum Santali Albi 3-5, Lignum Dalbergiae Odoriferae 7-10, Rhizoma Kaempferiae 5-8, Semen Myristicae 10-15, Fructus Choerospondiatis 10-15, Fructus Hippophae 10-15;
(2) extraction process
1. Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Rhizoma Kaempferiae and Semen Myristicae are put in the extractor that has the volatile oil catcher, extracting in water 4-6 hour, collect volatile oil, the water extract filters, and concentrates;
2. Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and Fructus Hippophae add 95% soak with ethanol 5-7 hour, extract medicinal residues and Radix Salviae Miltiorrhizae, Fructus Choerospondiatis and Fructus Hippophae behind the volatile oil with 95% ethanol extraction 2 times, and each 1 hour, filter, merging filtrate, concentrated, must ethanol extract;
3. the medicinal residues after the alcohol extraction add water boil 2 times, each 1.5 hours, filter, filtrate concentrates, merge with the concentrated solution of carrying the water extract behind the oil, water extract;
4. merge above-mentioned ethanol extract, water extract, drying under reduced pressure gets dry extract;
(3) drop pill preparation technology
The medicinal material extract dried cream powder is broken, cross 100 mesh sieves, get PEG400 and add volatile oil, be 8: 2 ratios in PEG4000 and PEG400 then, add PEG4000,80 ℃ of heating are stirred, fusing; The dried cream powder of weight such as adding stirs, and makes fusion, under 80 ℃ of insulations, is coolant with the dimethicone, drips system.
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| CN101554466B (en) * | 2009-05-19 | 2011-01-12 | 赤峰天奇制药有限责任公司 | Drug for treating coronary heart disease |
| CN102297922B (en) * | 2011-05-20 | 2013-11-13 | 四川科伦药物研究有限公司 | Fingerprint detecting method of volatile components in Guanxin seven-flavor dripping pills |
| WO2018090380A1 (en) * | 2016-11-21 | 2018-05-24 | 内蒙古天奇中蒙制药股份有限公司 | Capsule and preparation process therefor |
| CN108210810A (en) * | 2016-12-09 | 2018-06-29 | 内蒙古天奇中蒙制药股份有限公司 | A kind of preparation process of Chinese medicine composition |
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