CN1264488C - Simple vaginal ring making process - Google Patents
Simple vaginal ring making process Download PDFInfo
- Publication number
- CN1264488C CN1264488C CN 03116893 CN03116893A CN1264488C CN 1264488 C CN1264488 C CN 1264488C CN 03116893 CN03116893 CN 03116893 CN 03116893 A CN03116893 A CN 03116893A CN 1264488 C CN1264488 C CN 1264488C
- Authority
- CN
- China
- Prior art keywords
- controlled release
- rubber
- silicone rubber
- mixing
- release pipe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
The present invention relates to a simple preparation method for a pessary, which comprises: after silicon rubber is mixing to be smelted, a straight silicon rubber controlled release circular pipe is extruded from an extruding machine. The shaped silicon rubber controlled release pipe which is not vulcanized is cut into one section or multiple sections, and both ends of the section are oppositely connected to form a circular ring, or different medicine is added to the sections of the controlled release pipes, and the sections of the silicon rubber controlled release pipe containing the medicine are orderly oppositely connected so that one or multiple medicine storing warehouses are separated to be formed in the cavity of the pipe. Then, the controlled release pipes are put in a mold to be hot pressed, vulcanized and molded. The method has the advantages of no requirement of special equipment, simple operation and low cost and is suitable for large-scale production.
Description
Technical field:
The present invention relates to the medical apparatus field, be specifically related to a kind of preparation method of pessary.
Background technology:
From domestic and foreign literature data and the external pessary that has entered clinical market, all be to have adopted the injection molding vulcanization process to prepare pessary, yet adopt the injection mould sulfuration to produce, on the one hand, the equipment price costliness, technology is also complicated on the other hand, and that product takies the equipment time is long, the production cost height is difficult to accomplish large-scale production.
Summary of the invention:
Technical problem to be solved by this invention is to adopt common rubber extrusion equipment, provides a kind of easy, prepares the method for pessary cheaply.
Pessary production method disclosed by the invention is controlled release pipe formulation material-mixing silicon rubber to be extruded the silicone rubber controlled release pipe (see figure 1) of a straight type in extruder, its diameter, wall thickness is set by the demand size of all kinds of pessaries, this silicone rubber controlled release pipe that does not vulcanize typing is become one section or several sections along the transverse cuts of pipe, with the butt joint of two end end sockets, form the annulus (see figure 2) again; Or in each section controlled release pipe, add different medicines respectively, and again each section pastille silicone rubber controlled release pipe is docked successively, make in tube chamber, to be separated to form a Room or multicellular drug storehouse storage, put into the molding of mould hot-press vulcanization then, see Fig. 3-1～3.4.
The present invention prepares the simple and easy method of pessary, its key is to adjust mixing formula in various medical grade silicon rubbers commonly used at present, described medical grade silicon rubber commonly used comprises HTV (high temperature vulcanized or heat cure, molecular weight 20-100 ten thousand), RTV-2 (bi-component temperature sulfuration, molecular weight 0.74-11 ten thousand), LTV (liquid bi-component temperature vulcanizable silicone rubber, molecular weight 4000-50000), Dow corning silastic-382 medical grade silicone rubber, a Dow corning Q7 medical grade silicone rubber series and an implantation level MDX series, or the medical grade silicone rubber of other respective series.
The present invention prepares silicone rubber controlled release pipe that pessary adopts can suitably be adjusted elastomeric compound according to physics, chemical property and all kinds of preparation of different pharmaceutical to the requirement of release amount prescription, if select addition-type silicon rubber for use, then adopt platinum chromium thing to make catalyst, containing hydrogen silicone oil is made the vulcanization of cross-linking agent, and the baking temperature is controlled at 20 ℃-140 ℃.If select heat vulcanized silicone rubber for use, then adopt benzoyl peroxide to make cross-linking agent, the baking temperature is more than 140 ℃.The concrete scope of adjusting is (all being weight percentage):
(1) HTV (high temperature vulcanized or heat cure, molecular weight 20-100 ten thousand) silicone rubber 40-80%, silica 1 0-50%, hydroxy silicon oil 5-15%, medical grade barium sulfate 5-30%, iron oxide red 5g, benzoyl peroxide make cross-linking agent 0.5-1.5%.Put into rubber internal mixer and take out after mixing 40 minutes, be extruded into silicone rubber controlled release pipe at general rubber mixing machine then.
(2) add-on type RTV-2 (sulfuration of bi-component temperature, molecular weight 0.74-11 ten thousand) or LTV (liquid bi-component temperature vulcanizable silicone rubber, molecular weight 4000-50000), silicone rubber 40-80%, silicon dioxide 20-60%, hydroxy silicon oil 5-15%, medical grade barium sulfate 5-30%, iron oxide red 5g.Putting into rubber internal mixer takes out after mixing 40 minutes, be divided into two by weight, be the first and second two groups, the first group general rubber mixing machine add platinum catalyst 0.1-1% mixing 20 times evenly, the second group adds evenly being cut into small pieces of mixing 20 times of active hydrogen cross-linking agent 1-10% at general rubber mixing machine and puts into Rubber Extruder.
Described silicon dioxide can be fumed silica or precipitated silica or fumed silanized silicon dioxide.As the fumed silanized silicon dioxide of German wacker-HDK=H20, German digaoso-200 fumed silica, Japanese LP series precipitated silica etc.
Adopt the pastille controlled release pessary of the inventive method preparation, wherein said medicine can be selected for use:
Progestogens:
Levonorgestrel (Leuonogestral), gestodene (gestodene), promise medroxyprogesterone (Normegestodene), gestrinone (R-2323), triketone desogestrel, desogestrel (De80 goestral), norgestrienone (Norgestrienon), demegestone (Demegestone), promegestone (Promegestone), dydrogesterone (Isopregneone), trimegestone (Trimegestone), drospirenone (Drospirenone) etc.
Estrogens:
Estradiol (E2), estriol (E3), ethinylestradiol, nilestriol (E3 ether), premarin (conjugated Estrogenons) etc.
The gestation class:
Mifepristone (Ru-486) etc.
Anti-estrogens:
He is phenol (Tamofen), NSC-70735, Reynolds former times phenol etc. would be better.
Protein anabolic hormone:
Livial (Livial) etc.
Suppress prostaglandin synthetic drug in the uterine cavity:
Antiinflammatory is logical etc.
Hemorrhage:
Tranexamic acid, Trostin M, adona, aminomethylbenzoic acid, carbazochrome salicylate, peace base caproic acid etc.
The present invention prepares the method for pessary, simple to operate, need not special installation, thereby can adjust the release amount that the interior release area of tract is adjusted all kinds of pessaries within a large range easily, and in a pessary, can set more than one medicine releasing cavity easily as required, discharge multiple different types of medicine simultaneously.
Description of drawings
The silicone rubber controlled release pipe of the straight type of Fig. 1
The annulus that the butt joint of Fig. 2 two end end sockets forms
Wherein 1 is the end socket of butt joint
The multicell drug storehouse storage that Figure 31-3 forms
The specific embodiment:
Embodiment 1, left norethindrone contraception pessary
Take by weighing HTV (high temperature vulcanized or heat cure, molecular weight 500,000) silicone rubber 1kg, aerosil 0.5kg, hydroxy silicon oil 100g, medical grade barium sulfate 0.2kg, iron oxide red 5g.Put into rubber internal mixer and take out after mixing 40 minutes, add the 10g bis(2 at general rubber mixing machine then and ly evenly be cut into small pieces and put into Rubber Extruder for mixing 20 times,, extrude the silicone rubber controlled release pipe of internal diameter 3mm, wall thickness 1mm.Be cut into long 12.6cm, put into 20mg left side norethindrone plug (preparation method of application number 01126269.9 medicine applying system in cavity or duct), 180 ℃ of 10min hot-press vulcanizations of grinding tool are put in two connection then, and left norethindrone plug gets final product in the broken tract of repress.
Embodiment 2: the combined type pessary of gestodene+estradiol
Take by weighing the fumed silanized silicon dioxide 0.5kg of silicone rubber 1kg Germany wacker-HDK=H20 of RTV-2 (sulfuration of bi-component temperature, molecular weight 80,000), hydroxy silicon oil 30g, medical grade barium sulfate 0.1kg, iron oxide red 5g.Putting into rubber internal mixer takes out after mixing 40 minutes, be divided into two by weight, be divided into the first and second two groups, the first group general rubber mixing machine add platinum catalyst 0.5g mixing 20 times evenly, the second group adds evenly being cut into small pieces of mixing 20 times of active hydrogen cross-linking agent 5g at general rubber mixing machine and puts into Rubber Extruder, extrudes the silicone rubber controlled release pipe of internal diameter 2.6mm, wall thickness 1.2mm.Be cut into two of long 6.3cml, wherein put into 10mg gestodene's plug for one, another root is put into 5mg estradiol plug (01126700.3 1 kinds of controlled drug delivery devices that are used for the treatment of climacteric syndrome of the preparation method of the preparation method of application number 0ll26269.9 medicine applying system in cavity or duct and application number 01126269.9 medicine applying system in cavity or duct), 180 ℃ of 10min of grinding tool are put in the connection of four statures then, left norethindrone plug and estradiol plug get final product in the hot-press vulcanization, the broken tract of repress.
Claims (7)
1, a kind of preparation method of pessary, it is characterized in that described method is with after the mixing silicon rubber, in extruder, extrude the silicone rubber controlled release pipe of a straight type, this silicone rubber controlled release pipe that does not vulcanize typing is become one section along the transverse cuts of pipe, in this section controlled release pipe, add medicine, two ends end sockets butt joint with this section pastille silicone rubber controlled release pipe forms annulus again, makes to form a Room drug storehouse storage in this section tube chamber, obtains after putting into the molding of mould hot-press vulcanization then.
2, a kind of preparation method of pessary, it is characterized in that described method is with after the mixing silicon rubber, in extruder, extrude the silicone rubber controlled release pipe of a straight type, this silicone rubber controlled release pipe that does not vulcanize typing is become several sections along the transverse cuts of pipe, in each section controlled release pipe, add different medicines respectively, again the end cap of each section pastille silicone rubber controlled release pipe is docked the formation annulus successively, make in tube chamber to form multicellular drug storehouse storage, obtain after putting into the molding of mould hot-press vulcanization then.
3, the preparation method of pessary according to claim 1 and 2, it is characterized in that wherein said silicone rubber is selected from the HTV that molecular weight is 20-100 ten thousand, molecular weight is the RTV-2 of 0.74-11 ten thousand, molecular weight is the LTV of 4000-50000, Dow corning silastic-382 medical grade silicone rubber, or a Dow corning Q7 medical grade silicone rubber series and an implantation level MDX series.
4, the preparation method of pessary according to claim 1 and 2, the method that it is characterized in that wherein said mixing silicon rubber is that to get percentage by weight be that molecular weight is the HTV40-80% of 20-100 ten thousand, silica 1 0-50%, hydroxy silicon oil 5-15%, medical grade barium sulfate 5-30%, iron oxide red 5g is as the benzoyl peroxide 0.5-1.5% of cross-linking agent, put into rubber internal mixer and take out after mixing 40 minutes, be extruded into silicone rubber controlled release pipe at general rubber mixing machine then.
5, the preparation method of pessary according to claim 1 and 2, the method that it is characterized in that wherein said mixing silicon rubber is that to get percentage by weight be that molecular weight is that RTV-2 or the molecular weight of 0.74-11 ten thousand is 4000-50000LTV 40-80%, silicon dioxide 20-60%, hydroxy silicon oil 5-15%, medical grade barium sulfate 5-30%, iron oxide red 5g, putting into rubber internal mixer takes out after mixing 40 minutes, be divided into two by weight, be the first and second two groups, the first group general rubber mixing machine add platinum catalyst 0.1-1% mixing 20 times evenly, the second group evenly is cut into small pieces after general rubber mixing machine adds mixing 20 times of active hydrogen cross-linking agent 1-10% and puts into Rubber Extruder and be extruded into silicone rubber controlled release pipe.
6,, it is characterized in that wherein said silicon dioxide is selected from fumed silica or precipitated silica or fumed silanized silicon dioxide according to the preparation method of claim 4 or 5 described pessaries.
7, the preparation method of pessary according to claim 1 and 2 is characterized in that wherein said medicine is selected from prostaglandin synthetic drug in progestogens, estrogens, gestation class, anti-estrogens, protein anabolic hormone, the inhibition uterine cavity, antiinflammatory is logical or hemorrhage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03116893 CN1264488C (en) | 2003-05-14 | 2003-05-14 | Simple vaginal ring making process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03116893 CN1264488C (en) | 2003-05-14 | 2003-05-14 | Simple vaginal ring making process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1548013A CN1548013A (en) | 2004-11-24 |
| CN1264488C true CN1264488C (en) | 2006-07-19 |
Family
ID=34320519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03116893 Expired - Fee Related CN1264488C (en) | 2003-05-14 | 2003-05-14 | Simple vaginal ring making process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1264488C (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102327664A (en) * | 2010-07-14 | 2012-01-25 | 国家人口计生委科学技术研究所 | Intelligent pessulum with memory effect and preparation method thereof |
| CN103405810A (en) * | 2013-08-02 | 2013-11-27 | 苏州市马尔泰新材料有限公司 | Vagina mold containing methyl methacrylate resin |
| CN103445892A (en) * | 2013-08-02 | 2013-12-18 | 苏州市马尔泰新材料有限公司 | Vaginal stent containing methyl ester resin and diethylstilbestrol |
| CN103394127A (en) * | 2013-08-02 | 2013-11-20 | 苏州市马尔泰新材料有限公司 | Vaginal mould material containing traditional Chinese medicine and western medicine |
| CN103394128A (en) * | 2013-08-02 | 2013-11-20 | 苏州市马尔泰新材料有限公司 | Mould material containing ligusticum wallichii |
| CN103431930A (en) * | 2013-08-02 | 2013-12-11 | 苏州市马尔泰新材料有限公司 | Methyl ester resin-containing vaginal mold |
| CN104546267B (en) * | 2015-01-13 | 2017-01-04 | 安徽农业大学 | Birth control device and method of birth control thereof outside a kind of dog palace |
| RU2732822C2 (en) * | 2015-12-21 | 2020-09-22 | Байер Ой | Method for preparing a drug delivery device and a drug delivery device made by said method |
| KR20180093255A (en) * | 2015-12-21 | 2018-08-21 | 바이엘 오와이 | Manufacturing method of vaginal ring |
| CN113413358B (en) * | 2021-06-11 | 2022-11-15 | 上海达华药业有限公司 | Preparation method of contraceptive implant drug core |
-
2003
- 2003-05-14 CN CN 03116893 patent/CN1264488C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1548013A (en) | 2004-11-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1264488C (en) | Simple vaginal ring making process | |
| CN1154455C (en) | Intravaginal rings with insertable drug-containing core | |
| EP2456421B1 (en) | Multi-layered gradient vaginal ring | |
| US5788980A (en) | Intravaginal drug delivery device | |
| CN1210079C (en) | Medicine for vaginal ring and its application | |
| JP2011530379A (en) | Intravaginal device having a rigid support, method of making, and use thereof | |
| CN102743328B (en) | Intrauterine sustained control release drug delivery system adopting biodegradation material, and preparation method thereof | |
| US8980304B2 (en) | Barrel-shaped vaginal ring | |
| CN102861374A (en) | Pessulum capable of steadily releasing medicine | |
| CN1242819C (en) | Novel pessary and method for preparing same | |
| Liu et al. | Three-dimensional printing personalized acetaminophen sustained-release tablets using hot melt extrusion | |
| CN1899643B (en) | Pessary or intrauterine medicine release device containing antiestrogenic and anti-pregnant hormone composite preparation and its use | |
| CN102600001A (en) | Slow-release mifepristone vaginal ring preparation and application thereof | |
| CN1251654C (en) | Making process of intrauterine medicine releasing device | |
| CN100418594C (en) | Long-acting vagina administrator with precise control of medicine | |
| JP6278562B2 (en) | Method for producing medical drain tube, crosshead die and crosshead extruder | |
| CN1234350C (en) | Estrogen plaster used in cavity or duct | |
| CN102743329B (en) | Intrauterine sustained control release drug delivery system and preparation method thereof | |
| CN111171418A (en) | Composite material for environment-friendly medical rubber plug and preparation method and application thereof | |
| JP2016000484A (en) | Method for producing outer shape-deformed drain tube, crosshead die, and crosshead type extruder | |
| CN105641794A (en) | Cross-shaped drainage pipe and mold and machining method for forming drainage pipe once | |
| CN102327664A (en) | Intelligent pessulum with memory effect and preparation method thereof | |
| CN109248139A (en) | The preparation method and application of Levonorgestrel Compourd pesseulum | |
| CN109549855A (en) | A kind of paediatrics digestion infection nursing medicine feed device | |
| CN109248140A (en) | The preparation method and application of progesterone antibacterial pesseulum |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060719 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |