CN1261154C - Chinese medicine capsule for treating infection of urinary system and its preparing method - Google Patents
Chinese medicine capsule for treating infection of urinary system and its preparing method Download PDFInfo
- Publication number
- CN1261154C CN1261154C CN 200410074774 CN200410074774A CN1261154C CN 1261154 C CN1261154 C CN 1261154C CN 200410074774 CN200410074774 CN 200410074774 CN 200410074774 A CN200410074774 A CN 200410074774A CN 1261154 C CN1261154 C CN 1261154C
- Authority
- CN
- China
- Prior art keywords
- capsule
- rhizoma curcumae
- curcumae longae
- add
- volatile oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active - Reinstated
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a traditional Chinese medicine capsule for treating the infection of the urinary system, and a preparation method for the capsule. The capsule is characterized in that the capsule is prepared by mixing extracts of curcuma, phellodendron bark, gardenia and tribulus fruit with partial original medicinal powder of curcuma, wherein the capsule comprises the components of 16 to 16.7 weight portions of extracts, 8.3 to 9 weight portions of original medicinal powder, and 1 to 1.2 weight portions of volatile oil. The present invention is also characterized in that the content of geniposide in the capsule is required to be higher than or equal to 5 mg per capsule; the content of berberine is required to be high than or equal to 5.5 mg per capsule; the content of volatile oil is required to be higher than or equal to 0.0125 ml per capsule. The capsule of the present invention has good pharmacological action by the indication of pharmacological experiments.
Description
Affiliated technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of Chinese medicinal capsule agent that is used for the treatment of urinary system infection and preparation method thereof.
Background technology
Urinary system infection is a kind of commonly encountered diseases, and frequently-occurring disease claims urinary tract infection again, is meant bacteria attack urethra, bladder, ureter or kidney and causes the general name of infectious disease.Because often have any problem in the definite location of infecting, so be referred to as urinary system, pathogenic bacterium mainly are escherichia coli.According to the difference of primary disease site of pathological change, can be divided into lower urinary tract infection (comprising urethritis and cystitis) and upper urinary tract clinically and infect (comprising ureteritis and renal pelvis kidney road inflammation).But the lower urinary tract infection individualism, and upper urinary tract infects the lower urinary tract inflammation that often occurs together.This disease belongs to the category of the traditional Chinese medical science " stranguria ", and its clinical manifestation is: frequent micturition is short puckery, sound of rain pattering twinge when urgent micturition, urine, and the lower abdomen contracture, or pain is drawn the waist abdomen.Acute urinary system infection many because of part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels intrinsic heat or damp and hot due to, injure blood network person and also hematuria can occur.Chronic urinary system then because of all pouring with the passing of time, cross obey cold and cool, or weakness due to chronic disease, impairment caused by overstrain is excessive, so that asthenia of both the spleen and kidney, this disease is brought huge misery to the patient in clinical, and doctor trained in Western medicine a large amount of antibiotic of application in this disease of treatment carry out anti-inflammation, though it is evident in efficacy at short notice, but should disease very easily recur,, must strengthen dosage along with the generation of bacterial drug resistance, cause dysbacteriosis in patient's body, the state of an illness to increase the weight of, bring very big misery for patient's spirit, health.
It is the Mongolian medicinal preparation of being made by Rhizoma Curcumae Longae, Fructus Gardeniae, Cortex Phellodendri and Fructus Tribuli four Chinese medicine that an association's day loud, high-pitched sound four flavor soup loose, being used for the treatment of down, the urinary system road feel dyes; urine apolipsis; frequent micturition; urgent micturition, be with blood in the urine, the bladder twinge; diseases such as prostatitis; have good effect in clinical practice, but said preparation belongs to powder, the method that method for making adopts crude drug directly to pulverize; preparation process is relatively backward; the instructions of taking of this powder is that decocting boils and takes, and takes inconvenience, and the big and bitter in the mouth of dose is difficult for taking; volatile ingredient is difficult for preservation, also is unfavorable for preservation, transports and take;
Consult Patent data, do not retrieve relevant Patent data.
Summary of the invention
For these reasons, for overcoming the above shortcoming of powder, the present invention is according to Chinese medicine Rhizoma Curcumae Longae in prescription indication and the side, Cortex Phellodendri, Fructus Gardeniae, the character of the main effective ingredient of Fructus Tribuli, extract respectively and handle, main effective ingredient in the Rhizoma Curcumae Longae is volatile oil and curcumin chemical compounds, contain some resins in addition, saccharide, fatty acid, polypeptide and trace element, the main effect of volatile oil performance in the present invention, because Rhizoma Curcumae Longae is that rhizome is used as medicine, also contain a large amount of starch, therefore the present invention extracts volatile oil with most of Rhizoma Curcumae Longae, the main active of residue Rhizoma Curcumae Longae pulverization process Fructus Gardeniae is the iridoid based on jasminoidin, therefore adopts the 60-80% ethanol extraction; The main component of Cortex Phellodendri is a berberine, also contains compositions such as phellodendrine, magnoline, mucus juice, cupreol simultaneously, therefore adopts its main effective ingredient berberine constituents of 80-95% ethanol extraction; Fructus Tribuli (little stir-fry) mainly contains alkaloid, flavone, saponin, sterols composition, so the method that Fructus Tribuli (little stir-fry) adopts decocting to boil is extracted; Consider the comprehensive function of Chinese medicine compound, the medicinal residues that Rhizoma Curcumae Longae is carried after medicinal residues aqueous solution behind the volatile oil, Fructus Gardeniae, the Cortex Phellodendri alcohol extraction decoct with Fructus Tribuli.The extractum that said extracted liquid merges after concentrating directly mixes with the Rhizoma Curcumae Longae coarse powder, adds Rhizoma Curcumae Longae volatile oil again, the preparation capsule.Because after the thick paste drying and crushing that extraction process is made, its viscosity is big, and Rhizoma Curcumae Longae is unique rhizome class medical material in the our four Chinese medicine material, starch-containing amount is bigger, and for reducing dose, the present invention directly adds the Rhizoma Curcumae Longae crude drug and plays adjuvant.Through repetition test repeatedly, finally determine Rhizoma Curcumae Longae process using Rhizoma Curcumae Longae recipe quantity 2/3rds extract volatile oil decocting in water more earlier; Play the adjuvant effect after 1/3rd recipe quantity is pulverized and directly add in the finished product,
The main effective ingredient of each flavour of a drug is not only extracted and kept to crude drug extraction process of the present invention targetedly, considered the synergistic function of medicaments compound composition simultaneously.Adopt prepared capsule of the present invention need not add any other pharmaceutic adjuvant, both save production cost, simplified technology, reached reduction viscosity again, reduce the purpose (it is 3-5g that former powder need be taken amount of formulation at every turn, and the each dose of preparation of the present invention only needs 1-1.25g) of dose.Adopt capsule and the former powder comparison effective ingredient of the present invention's preparation to divide the content height, the quality of the pharmaceutical preparations is stablized, and more convenient patient takes, accumulating and carrying; The present invention has increased the quality standard of effective ingredient in preparation process, more the capsular quality of control the present invention of science; The pharmacological results shows that the capsule of the present invention's preparation has better pharmacological action.
The composition weight portion of capsule of the present invention is: extract 16-16.7, former medicated powder 8.3-9, volatile oil 1-12; Wherein the jasminoidin content in the capsule must not be lower than the 5mg/ grain, and content of berberine must not be lower than the 5.5mg/ grain, and volatile oil content must not be lower than the 0.0125ml/ grain.
The present invention is achieved through the following technical solutions:
One, process recipes
(1) crude drug prescription proportioning weight portion of the present invention is:
Rhizoma Curcumae Longae 25-27, Cortex Phellodendri 15-17, Fructus Gardeniae 20-22, Fructus Tribuli (little stir-fry) 25-27.
(2) get Rhizoma Curcumae Longae (recipe quantity 2/3rds) coarse powder, add 8-12 times of water gaging, extract volatile oil with steam distillation, the medicinal residues aqueous solution after the distillation is standby;
(3) get the Cortex Phellodendri coarse powder and add 80%-95% ethanol 6-10 and doubly measure, reflux, extract,, merge extractive liquid, reclaims ethanol, and medicinal liquid, medicinal residues are standby;
(4) get the Fructus Gardeniae coarse powder and add 60%-80% ethanol 6-10 and doubly measure, reflux, extract,, merge extractive liquid, reclaims ethanol, and medicinal liquid, medicinal residues are standby.
(5) get Fructus Tribuli and add 8-12 times of water gaging and soaked 1-2 hour, merge above-mentioned Rhizoma Curcumae Longae medicinal residues aqueous solution, Cortex Phellodendri, gardenia dregs decoct to be extracted, collecting decoction, and merge the thick paste that is concentrated into relative density 1.35～1.40 (50 ℃) with above-mentioned Cortex Phellodendri, Fructus Gardeniae medicinal liquid;
(6) thick paste added the former powder of Rhizoma Curcumae Longae (recipe quantity 1/3rd) of 60-100 mesh sieve, and drying and crushing adds Rhizoma Curcumae Longae volatile oil, and is encapsulated.
Do not add other any pharmaceutic adjuvant when adopting above prepared capsule.
The optimum weight portion of the crude drug prescription proportioning of above capsule is:
Rhizoma Curcumae Longae 26.4, Cortex Phellodendri 15.74, Fructus Gardeniae 21.12, Fructus Tribuli (little stir-fry) 26.4
Two, check and analysis
The check and analysis of jasminoidin
Experimental technique: the detection method according to [assay] in 201 pages of Fructus Gardeniaes of the Pharmacopoeia of the People's Republic of China (version in 2000, an one) is carried out check and analysis to preparation.Wherein soup looses and gets 5g, adds 10 times of water gagings and decocts 1 hour, and decoction liquor filters, and filtrate adds methanol and is diluted to desired concn, measures the content of decoction liquor again.Testing result: see Table 1
The content of jasminoidin relatively in table 1 preparation
| Group | Jasminoidin content (dosage of mg/) | Jasminoidin percentage composition (%) |
| Association's day-loud, high-pitched sound four flavor soup loose | 18 | 0.36 |
| Capsule of the present invention | 30 | 2.40 |
The check and analysis of berberine
Experimental technique:
Experimental apparatus: Waters high performance liquid chromatograph (600 pumps, 2487 detectors), Millinium32 chromatography software)
Chromatographic condition: YWG-C18 (4*150mm, 10 μ m) detects wavelength: 345nm, flow velocity: 1.0ml/min;
Mobile phase: ethyl acetate-formic acid-dehydrated alcohol (110: 30: 60)
Experimental technique: get the methanol solution that the berberine reference substance is made into 0.11mg/ml, other gets preparation 20mg of the present invention, put in the 500ml volumetric flask and also be settled to scale with the methanol ultrasonic dissolution, the leaching supernatant, soup looses and gets 5g, adds 10 times of water gagings and decocts 1 hour, and decoction liquor filters, filtrate adds the methanol dilution and is settled to 25ml, gets reference substance solution and sample solution 10 μ l sample introduction and calculating respectively.Result such as table 2
The content of berberine relatively in table 2 preparation
| Group | Content of berberine (dosage of mg/) | Berberine percentage composition (%) |
| Association's day-loud, high-pitched sound four flavor soup loose | 21.04 | 0.42 |
| Capsule of the present invention | 34.48 | 2.52 |
Volatile oil contents is measured
Experimental technique: survey according to the Pharmacopoeia of the People's Republic of China (version in 2000, an one) appendix X D volatile oil
The method of deciding is measured volatile oil, reads the volatilization oil mass.(owing to take after the decoction of soup aproll, so the volatile oil component basic loss)
Measurement result sees Table 3
Volatile oil contents is measured in table 3 preparation
| Group | Volatile oil content (%) |
| Capsule of the present invention | 6.0 |
Conclusion: above check and analysis experiment shows, obviously improves with the active constituent content of the capsule of prepared of the present invention, proves absolutely that technology of the present invention has practical significance.
Three, pharmacology embodiment
Experiment medicine: association's day-loud, high-pitched sound four flavor soup diffusing (covering pharmaceutical Co. Ltd in the Ulan Hot)
Capsule of the present invention (Qianluchun Science and Technology Co., Ltd., Beijing's laboratory provides)
Distilled water (Qianluchun Science and Technology Co., Ltd., Beijing's laboratory provides)
Laboratory animal: cleaning level KM kind mice (18-22g), SD rat (180-220g).
Experiment reagent: agar (Nat'l Pharmaceutical ﹠ Biological Products Control Institute)
Experimental strain: bacteriostatic experiment escherichia coli in the body, fresh inclined-plane inserts 50 milliliters of meat soups, and 150 rev/mins, 3 ℃ of shaking tables were cultivated 6-7 hour, and 2500 rev/mins, 10 minutes are centrifugal, and taking precipitate is diluted to 1.0-1.2 * 10 with physiological saline solution
7Individual/ml (viable bacteria counting method), standby.
Embodiment 1
Experimental technique: 160 of mices are divided into 8 groups, 20 every group at random, male and female half and half, the blank stomach distilled water 0.5ml that irritates, the diffusing group of association's day-loud, high-pitched sound four flavor soup, capsule group of the present invention all (are equivalent to 0.487g capsule/kg according to 1.75g crude drug/kg, 1.95g the gastric infusion of powder/kg), the administration volume is 0.5ml, successive administration 3 days, once a day, the administration volume is 0.5ml, 1 hour lumbar injection bacterium of last administration infects the liquid escherichia coli, and death toll in the record mice 24 hours sees Table 3
Bacteriostatic experiment result in the table 3 preparation body
| Group | Number of animals (only) | Dosage (the g crude drug/kg) | 24 hours death toll (only) | Mortality rate (%) |
| Blank group | 20 | - | 20 | 100 |
| Association's day-loud, high-pitched sound four flavor soup loose | 20 | 30.8 | 16 | 80 * |
| Capsule of the present invention | 20 | 30.8 | 10 | 50 ** |
Annotate:
*P＜0.01,
*P＜0.05
Embodiment 2
Influence to the formation of rat granuloma
The rat granuloma model: the rat back midline is got 2.0*2.0CM
2The area depilation, sterilization, 2 milliliters in subcutaneous injection 2% agar.
Experimental technique: the next day get 80 of modeling rats, be divided into 8 groups, gastric infusion, blank group is irritated stomach distilled water 1ml, and the experimental group dosage is that 2.43g crude drug/kg (is equivalent to 0.686g capsule/kg, 2.75g powder/kg), the administration volume is 1ml, administration every day 1 time, continuous 14 days, rat was put to death in the last administration in 1 hour, cut off skin, peel off the granuloma agar block, take by weighing weight in wet base, calculate the granuloma suppression ratio, see Table 4
The table 4 pair granulomatous influence of rat agar
| Group | Number of animals (only) | Dosage (the g crude drug/kg) | Granuloma weight in wet base (g) | Suppression ratio (%) |
| Blank group | 10 | - | 2.43±0.82 | - |
| Association's day-loud, high-pitched sound four flavor soup loose | 10 | 1.75 | 1.65±0.47 **[ *] | 32.1 |
| Capsule of the present invention | 10 | 1.75 | 1.39±0.34 **[ *] | 42.8 |
Annotate: compare with the blank group
*P＜0.01, compare with positive controls [
*] P＜0.05 conclusion: show that by pharmacological evaluation preparation of the present invention is compared pharmacological action with decoction pulvis and obviously strengthened.
Four, preparation embodiment
Embodiment 1
(1) crude drug prescription proportioning is:
Rhizoma Curcumae Longae 264 grams, Cortex Phellodendri 157.4 grams, Fructus Gardeniae 211.2 grams, Fructus Tribuli (little stir-fry) 264 grams;
(2) get Rhizoma Curcumae Longae (recipe quantity 2/3rds) coarse powder and add 10 times of water gagings, press steam distillation and extracted volatile oil 6 hours, divide and get the airtight preservation of volatile oil, the medicinal residues aqueous solution after the distillation is standby.
(3) get the Cortex Phellodendri coarse powder and add 8 times of amounts of 95% ethanol, reflux, extract, 3 times, each 1 hour, merge extractive liquid, reclaimed ethanol, and medicinal liquid, medicinal residues are standby
(4) get the Fructus Gardeniae coarse powder and add 8 times of amounts of 70% ethanol, reflux, extract, 2 times, each 1 hour, merge extractive liquid, reclaimed ethanol, and medicinal liquid, medicinal residues are standby.
(5) get Fructus Tribuli and add 10 times of water gagings and soaked 1 hour, merge above-mentioned Rhizoma Curcumae Longae medicinal residues aqueous solution, Cortex Phellodendri, gardenia dregs decocted 3 times each 1 hour, collecting decoction, and merge the thick paste that is concentrated into relative density 1.35～1.40 (50 ℃) with above-mentioned Cortex Phellodendri, Fructus Gardeniae medicinal liquid,
(6) added the former powder of Rhizoma Curcumae Longae (recipe quantity 1/3rd) of 80 mesh sieves in the thick paste, drying and crushing adds Rhizoma Curcumae Longae volatile oil, encapsulated 1000.
Annotate: testing result: jasminoidin content: 6mg/ grain, content of berberine: 6.3mg/ grain, volatile oil content: 0.015ml/ grain.
Embodiment 2
(1) crude drug prescription proportioning is:
Rhizoma Curcumae Longae 250 grams, Cortex Phellodendri 150 grams, Fructus Gardeniae 200 grams, Fructus Tribuli (little stir-fry) 250 grams;
(2) get Rhizoma Curcumae Longae (recipe quantity 2/3rds) coarse powder and add 8 times of water gagings, press steam distillation and extracted volatile oil 8 hours, divide and get the airtight preservation of volatile oil, the medicinal residues aqueous solution after the distillation is standby.
(3) get the Cortex Phellodendri coarse powder and add 6 times of amounts of 80% ethanol, reflux, extract, 3 times, each 1 hour, merge extractive liquid, reclaimed ethanol, and medicinal liquid, medicinal residues are standby
(4) get the Fructus Gardeniae coarse powder and add 6 times of amounts of 60% ethanol, reflux, extract, 2 times, each 1 hour, merge extractive liquid, reclaimed ethanol, and medicinal liquid, medicinal residues are standby.
(5) get Fructus Tribuli and add 8 times of water gagings and soaked 1.5 hours, merge above-mentioned Rhizoma Curcumae Longae medicinal residues aqueous solution, Cortex Phellodendri, gardenia dregs decocted 3 times each 1 hour, collecting decoction, and merge the thick paste that is concentrated into relative density 1.35～1.40 (50 ℃) with above-mentioned Cortex Phellodendri, Fructus Gardeniae medicinal liquid,
(6) added the former powder of Rhizoma Curcumae Longae (recipe quantity 1/3rd) of 100 mesh sieves in the thick paste, drying and crushing adds Rhizoma Curcumae Longae volatile oil, encapsulated 1000.
Annotate: testing result: jasminoidin content: 5.9mg/ grain, content of berberine: 6.175mg/ grain, volatile oil: 0.0145ml/ grain.
Embodiment 3
(1) crude drug prescription proportioning is:
Rhizoma Curcumae Longae 270 grams, Cortex Phellodendri 170 grams, Fructus Gardeniae 220 grams, Fructus Tribuli (little stir-fry) 270 grams;
(2) get Rhizoma Curcumae Longae (recipe quantity 2/3rds) coarse powder and add 12 times of water gagings, press steam distillation and extracted volatile oil 4 hours, divide and get the airtight preservation of volatile oil, the medicinal residues aqueous solution after the distillation is standby.
(3) get the Cortex Phellodendri coarse powder and add 10 times of amounts of 90% ethanol, reflux, extract, 3 times, each 1 hour, merge extractive liquid, reclaimed ethanol, and medicinal liquid, medicinal residues are standby
(4) get the Fructus Gardeniae coarse powder and add 10 times of amounts of 80% ethanol, reflux, extract, 2 times, each 1 hour, merge extractive liquid, reclaimed ethanol, and medicinal liquid, medicinal residues are standby.
(5) get Fructus Tribuli and add 12 times of water gagings and soaked 2 hours, merge above-mentioned Rhizoma Curcumae Longae medicinal residues aqueous solution, Cortex Phellodendri, gardenia dregs decocted 3 times each 1 hour, collecting decoction, and merge the thick paste that is concentrated into relative density 1.35～1.40 (50 ℃) with above-mentioned Cortex Phellodendri, Fructus Gardeniae medicinal liquid,
(6) added the former powder of Rhizoma Curcumae Longae (recipe quantity 1/3rd) of 60 mesh sieves in the thick paste, drying and crushing adds Rhizoma Curcumae Longae volatile oil, encapsulated 1000.
Annotate: testing result: jasminoidin content: 6.025mg/ grain, content of berberine: 6.175mg/ grain, volatile oil content: 0.015ml/ grain.
Embodiment 4
(1) crude drug prescription proportioning is:
Rhizoma Curcumae Longae 260 grams, Cortex Phellodendri 160 grams, Fructus Gardeniae 210 grams, Fructus Tribuli (little stir-fry) 260 grams;
(2) get Rhizoma Curcumae Longae (recipe quantity 2/3rds) coarse powder and add 10 times of water gagings, press steam distillation and extracted volatile oil 8 hours, divide and get the airtight preservation of volatile oil, the medicinal residues aqueous solution after the distillation is standby.
(3) get the Cortex Phellodendri coarse powder and add 8 times of amounts of 85% ethanol, reflux, extract, 3 times, each 1 hour, merge extractive liquid, reclaimed ethanol, and medicinal liquid, medicinal residues are standby
(4) get the Fructus Gardeniae coarse powder and add 8 times of amounts of 70% ethanol, reflux, extract, 2 times, each 1 hour, merge extractive liquid, reclaimed ethanol, and medicinal liquid, medicinal residues are standby.
(5) get Fructus Tribuli and add 10 times of water gagings and soaked 1 hour, merge above-mentioned Rhizoma Curcumae Longae medicinal residues aqueous solution, Cortex Phellodendri, gardenia dregs decocted 3 times each 1 hour, collecting decoction, and merge the thick paste that is concentrated into relative density 1.35～1.40 (50 ℃) with above-mentioned Cortex Phellodendri, Fructus Gardeniae medicinal liquid,
(6) added the former powder of Rhizoma Curcumae Longae (recipe quantity 1/3rd) of 80 mesh sieves in the thick paste, drying and crushing adds Rhizoma Curcumae Longae volatile oil, encapsulated 1000.
Annotate: testing result: jasminoidin content: 5.75mg/ grain, content of berberine: 6.125mg/ grain, volatile oil content: 0.0145ml/ grain.
Embodiment 5
(1) crude drug prescription proportioning is:
Rhizoma Curcumae Longae 250 grams, Cortex Phellodendri 150 grams, Fructus Gardeniae 210 grams, Fructus Tribuli (little stir-fry) 270 grams;
(2) get Rhizoma Curcumae Longae (recipe quantity 2/3rds) coarse powder and add 12 times of water gagings, press steam distillation and extracted volatile oil 8 hours, divide and get the airtight preservation of volatile oil, the medicinal residues aqueous solution after the distillation is standby.
(3) get the Cortex Phellodendri coarse powder and add 6 times of amounts of 95% ethanol, reflux, extract, 3 times, each 1 hour, merge extractive liquid, reclaimed ethanol, and medicinal liquid, medicinal residues are standby
(4) get the Fructus Gardeniae coarse powder and add 8 times of amounts of 70% ethanol, reflux, extract, 2 times, each 1 hour, merge extractive liquid, reclaimed ethanol, and medicinal liquid, medicinal residues are standby.
(5) get Fructus Tribuli and add 8 times of water gagings and soaked 1.5 hours, merge above-mentioned Rhizoma Curcumae Longae medicinal residues aqueous solution, Cortex Phellodendri, gardenia dregs decocted 3 times each 1 hour, collecting decoction, and merge the thick paste that is concentrated into relative density 1.35～1.40 (50 ℃) with above-mentioned Cortex Phellodendri, Fructus Gardeniae medicinal liquid,
(6) added the former powder of Rhizoma Curcumae Longae (recipe quantity 1/3rd) of 80 mesh sieves in the thick paste, drying and crushing adds Rhizoma Curcumae Longae volatile oil, encapsulated 1000.
Annotate: testing result: jasminoidin content: 5.925mg/ grain, bark of a cork tree alkali content: 6.125mg/ grain, volatile oil content: 0.01475ml/ grain.
Claims (1)
1. Chinese medicinal capsule agent that is used for the treatment of urinary system infection is characterized in that this capsule is by following method preparation:
(1) crude drug prescription proportioning weight portion is: Rhizoma Curcumae Longae 25-27, Cortex Phellodendri 15-17, Fructus Gardeniae 20-22, little stir-baked FRUCTUS TRIBULI 25-27;
(2) get the Rhizoma Curcumae Longae coarse powder of recipe quantity 2/3rds, add 8-12 times of water gaging, extract volatile oil with steam distillation, the medicinal residues aqueous solution after the distillation is standby;
(3) get the Cortex Phellodendri coarse powder and add 80%-95% ethanol 6-10 and doubly measure, reflux, extract,, merge extractive liquid, reclaims ethanol, clear paste, medicinal residues are standby;
(4) get the Fructus Gardeniae coarse powder and add 60%-80% ethanol 6-10 and doubly measure, reflux, extract,, merge extractive liquid, reclaims ethanol, clear paste, medicinal residues are standby;
(5) get Fructus Tribuli and add 8-12 times of water gaging and soaked 1-2 hour, merge above-mentioned Rhizoma Curcumae Longae medicinal residues aqueous solution, Cortex Phellodendri, gardenia dregs decoct and extract, collecting decoction, and merge the thick paste that is concentrated into 50 ℃ of relative density 1.35-1.40 with above-mentioned Cortex Phellodendri, Fructus Gardeniae clear paste;
(6) thick paste added 1/3rd the former powder of Rhizoma Curcumae Longae of the recipe quantity of 60-100 mesh sieve, and drying and crushing adds Rhizoma Curcumae Longae volatile oil, and is encapsulated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410074774 CN1261154C (en) | 2004-09-15 | 2004-09-15 | Chinese medicine capsule for treating infection of urinary system and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410074774 CN1261154C (en) | 2004-09-15 | 2004-09-15 | Chinese medicine capsule for treating infection of urinary system and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1616022A CN1616022A (en) | 2005-05-18 |
| CN1261154C true CN1261154C (en) | 2006-06-28 |
Family
ID=34765370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410074774 Active - Reinstated CN1261154C (en) | 2004-09-15 | 2004-09-15 | Chinese medicine capsule for treating infection of urinary system and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1261154C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110890B (en) * | 2013-02-05 | 2015-03-18 | 董玉 | Effective part of Xierigasiwei (Mongolian medicine) as well as preparation method, quality detection method and application thereof |
| CN103055191B (en) * | 2013-02-22 | 2015-07-01 | 云南理想药业有限公司 | Preparation method and quality detection method of traditional Chinese medicine for treating hematuresis caused by nephritis |
| CN114177264A (en) * | 2021-12-23 | 2022-03-15 | 赤峰学院 | Traditional Chinese medicine composition for treating diabetes and nephritis and preparation method and application thereof |
-
2004
- 2004-09-15 CN CN 200410074774 patent/CN1261154C/en active Active - Reinstated
Also Published As
| Publication number | Publication date |
|---|---|
| CN1616022A (en) | 2005-05-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100337651C (en) | Chinese medicine composition for preventing bird flu | |
| CN100342889C (en) | Chinese medicine for treating gout | |
| CN100345572C (en) | Medicine composition for curing exogenous fever and process for preparing the same | |
| CN1813961A (en) | Medicinal composition for treating astriction | |
| CN101732668A (en) | Preparation method of Chinese medicinal composition for treating urinary system infection | |
| CN1293898C (en) | Medicine composition for treating viral hepatitis and its preparation method | |
| CN1261154C (en) | Chinese medicine capsule for treating infection of urinary system and its preparing method | |
| CN101041037A (en) | Drug for curing diabetes and nephropathy and its preparing method | |
| CN1823982A (en) | Chinese medicinal preparation for liver soothing and speen fortifying and its manufacturing method | |
| CN1899499A (en) | Chinese medicine composition for treating cold and its preparing method and use | |
| CN114515307A (en) | A veterinary drug composition or animal food additive for preventing and/or treating kidney diseases | |
| CN1421229A (en) | Chinese medicine for treating hepatocirrhosis, hepatitis and liver cancer | |
| CN101176779B (en) | Preparation method of enema for curing gynecology inflammation | |
| CN104324316A (en) | Application of traditional Chinese medicine composition to prepare medicines treating colorectal cancer | |
| CN1139565A (en) | Nourishing medicine for preventing and curing toxic and side effect after tumor radiotherapy and chemotherapy and preparation method | |
| CN103316103B (en) | Coccidian-expelling and dysentery-stopping mixture for livestock and preparation method thereof | |
| CN103110100A (en) | Korean medical healthcare food composition as well as preparation method and application thereof | |
| CN1435247A (en) | Chinese medicine preparation for treating lithiasis in urinary system and urethral infection, and preparing method thereof | |
| CN1298351C (en) | Chinese medicine oral preparaton for treating urinary system infestation and its preparation method | |
| CN1237983C (en) | Compound rhizome of Cyrtomium aspirin tablet | |
| CN1237998C (en) | Effervescence tablet for treating children's cough and asthma and its preparation | |
| CN1212150C (en) | Medicine for treating virus hepatitis and its preparation method | |
| CN1682868A (en) | Compound preparation for treating liver fibrosis and its preparing method | |
| CN1186062C (en) | Antiinflammatory hemostatic gynecologic medicine and use thereof | |
| CN1768775A (en) | Prescription containing sweet clover component and its formulation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| RR01 | Reinstatement of patent right |
Former decision: cessation of patent right due to non-payment of the annual fee Former decision publication date: 20081112 |
|
| DD01 | Delivery of document by public notice |
Addressee: Zhang Zhengsheng Document name: Notification of Decision on Request for Restoration of Right |
|
| ASS | Succession or assignment of patent right |
Owner name: YANBIAN MEDICINE INDUSTRY CO LTD, AODONG Free format text: FORMER OWNER: ZHANG PING Effective date: 20100715 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 510610 ROOM 802, 8/F IYAGE, TIANYU GARDEN, NO.150, LINHE MIDDLE ROAD, GUANGZHOU CITY, GUANGDONG PROVINCE TO: 133700 NO.2158, AODONG STREET, DUNHUA CITY, JILIN PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20100715 Address after: 133700 Jilin province Aodong Dunhua Street No. 2158 Patentee after: Yanbian Medicine Industry Co., Ltd., Aodong Address before: 510610 Guangdong city of Guangzhou province forest and Road No. 150, Room 802 on the eighth floor of Tianyu Garden Plaza Accord Patentee before: Zhang Ping |