CN1261097C - Nisoldipine capsule composition - Google Patents
Nisoldipine capsule composition Download PDFInfo
- Publication number
- CN1261097C CN1261097C CN 02104211 CN02104211A CN1261097C CN 1261097 C CN1261097 C CN 1261097C CN 02104211 CN02104211 CN 02104211 CN 02104211 A CN02104211 A CN 02104211A CN 1261097 C CN1261097 C CN 1261097C
- Authority
- CN
- China
- Prior art keywords
- nisoldipine
- soft capsule
- preparation
- glycerol
- capsule preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- VKQFCGNPDRICFG-UHFFFAOYSA-N methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1C1=CC=CC=C1[N+]([O-])=O VKQFCGNPDRICFG-UHFFFAOYSA-N 0.000 title claims abstract description 37
- 229960000227 nisoldipine Drugs 0.000 title claims abstract description 37
- 239000007963 capsule composition Substances 0.000 title description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 45
- 239000007901 soft capsule Substances 0.000 claims abstract description 31
- 238000002360 preparation method Methods 0.000 claims abstract description 22
- 239000004094 surface-active agent Substances 0.000 claims abstract description 15
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 9
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 9
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 6
- 239000008158 vegetable oil Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 235000012424 soybean oil Nutrition 0.000 claims description 4
- 239000003549 soybean oil Substances 0.000 claims description 4
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 3
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 3
- 229940113124 polysorbate 60 Drugs 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- 239000000203 mixture Substances 0.000 abstract description 9
- 239000007788 liquid Substances 0.000 abstract description 6
- 239000002904 solvent Substances 0.000 abstract description 5
- 239000002552 dosage form Substances 0.000 abstract description 4
- 239000004064 cosurfactant Substances 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 239000000470 constituent Substances 0.000 description 8
- 239000002775 capsule Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 3
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 2
- 229960001597 nifedipine Drugs 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 229940097320 beta blocking agent Drugs 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000000297 inotrophic effect Effects 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 230000036581 peripheral resistance Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 02104211 CN1261097C (en) | 2002-02-09 | 2002-02-09 | Nisoldipine capsule composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 02104211 CN1261097C (en) | 2002-02-09 | 2002-02-09 | Nisoldipine capsule composition |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1436535A CN1436535A (en) | 2003-08-20 |
CN1261097C true CN1261097C (en) | 2006-06-28 |
Family
ID=27627961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 02104211 Expired - Fee Related CN1261097C (en) | 2002-02-09 | 2002-02-09 | Nisoldipine capsule composition |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1261097C (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1771949B (en) * | 2005-11-06 | 2011-04-20 | 沈阳药科大学 | Soft nimodipine capsule and its preparation |
CN102247598A (en) * | 2011-06-13 | 2011-11-23 | 浙江爱生药业有限公司 | Oil-soluble drug composition |
CN106511294B (en) * | 2016-12-09 | 2019-05-07 | 汤臣倍健股份有限公司 | A kind of soft capsule and preparation method thereof |
-
2002
- 2002-02-09 CN CN 02104211 patent/CN1261097C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1436535A (en) | 2003-08-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PP01 | Preservation of patent right |
Effective date of registration: 20130701 Granted publication date: 20060628 |
|
RINS | Preservation of patent right or utility model and its discharge | ||
PD01 | Discharge of preservation of patent | ||
PD01 | Discharge of preservation of patent |
Date of cancellation: 20140101 Granted publication date: 20060628 |
|
PP01 | Preservation of patent right | ||
PP01 | Preservation of patent right |
Effective date of registration: 20140101 Granted publication date: 20060628 |
|
PD01 | Discharge of preservation of patent |
Date of cancellation: 20140701 Granted publication date: 20060628 |
|
RINS | Preservation of patent right or utility model and its discharge | ||
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060628 Termination date: 20130209 |