CN1259859A - Dual vial connecting system for lyophilized products - Google Patents
Dual vial connecting system for lyophilized products Download PDFInfo
- Publication number
- CN1259859A CN1259859A CN 97182334 CN97182334A CN1259859A CN 1259859 A CN1259859 A CN 1259859A CN 97182334 CN97182334 CN 97182334 CN 97182334 A CN97182334 A CN 97182334A CN 1259859 A CN1259859 A CN 1259859A
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- plastic
- bottle
- airtight connection
- tubular glass
- bushing
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Abstract
For temporary connection of two containers such as vials, bottles, etc..., with guaranteed tightness thanks to a cylindrical screwing closing and connection plastic sleeve having a plastic perforable membrane located between its upper portion and lower portion including an elastomer sealing ring fixed around a cylindrical plastic skirt located in the inner lower portion, and an elastomer sealing plug fixed by the collar and the annular rib in the inner upper portion, a cylindrical plastic skirt coming in contact with the inner neck of the glass or plastic vial, the whole assuring complete tightness of the system when stored and when used for the resonstitution of the product contained in a glass or plastic vial with a corresponding solvent contained in a plastic solvent bottle.
Description
The present invention relates to a kind of shaped double tube bottle connecting device, be used for connecting two containers temporarily, these two containers are tubular glass or plastic bottle and a plastic solvent bottle normally, its objective is a kind of dry thing and the reorganization of a kind of corresponding solvent, described dry thing is a kind of lyophilization thing that for example is contained in tubular glass or the plastic bottle, powder etc., corresponding solvent is contained in the plastic solvent bottle, connecting device has a columniform airtight connection plastic bushing, it has a bottom, this bottom has a clamp device inwardly, be connected with tubular glass or the reliable of plastic bottle cervical region in order to assurance, with a top, this top has female thread, in order to plastic solvent bottle and the all-in-one-piece plastic sheeting of being threaded, when the internal thread part timesharing that is screwed into airtight connection plastic bushing top, this thin film is pierced through by the convergent mouth of pipe of plastic solvent bottle.
In view of the reason of aspects such as stable, fresh, sale, these two kinds of products are stored in the independent container before it uses.In storage process, these two containers seal.
The object of the present invention is to provide a kind of dual connection case, it does not need a rubber stopper, but can guarantee to be equipped with the tubular glass of lyophilization thing or the sealing of plastic bottle, and being tightly connected between tubular glass or plastic bottle and the solvent bottle in the regrouping process.
The objective of the invention is to realize by airtight connection plastic bushing, this sleeve pipe has the thin film that can bore a hole that the upper internal threaded part of airtight connection plastic bushing is come with lower isolation, an inner surface is the interior bottom that columniform skirt section is arranged on airtight connection plastic bushing, and extend downwards from the lower surface of the thin film that can bore a hole, there is a contacted external diameter of interior neck wall with tubular glass or plastic bottle in described skirt section, an elastic seal ring is installed in the uppermost position in fig-ure place around the described outer skirt surface, the middle part of an elastic packing plug has one and cuts zone and a cavity in advance, described sealing-plug be arranged on a cylindrical flange around, this flange is arranged on the internal upper part of airtight connection plastic bushing, and extend upward from the upper surface of the thin film that can bore a hole, so the thin film that can bore a hole, cylindrical skirt is the described airtight global formation parts that are connected plastic bushing with flange.
According to a preferred embodiment of the present invention, clamp device comprises that the screw thread inwall of an interior bottom cooperates with the respective threaded of tubular glass or plastics bottleneck outer surface.In order to prevent that airtight connection plastic bushing breaks away from from tubular glass or plastic bottle, inwall is provided with tooth, meshes with the respective teeth with tubular glass or plastics bottleneck outer surface.And screw thread is interrupted by some vertical grooves, when airtight connection plastic bushing only partly is screwed on the described phial, can keep an open type from tubular glass or plastic bottle the inside to the outside to connect.
According to another embodiment of the invention, the projection of inside extension is arranged at the bottom of airtight connection plastic bushing, with the annular protrusion interlock of tubular glass or plastics bottleneck outer surface.
According to a further advantageous embodiment of the invention, there is a cavity at the middle part of elastic packing plug, reserves thin zone to be used as elastic film, and this thin film is cut in the middle in advance.When the internal thread part timesharing that the plastic solvent bottle is screwed into airtight connection plastic bushing top, what the convergent mouth of pipe of described plastic solvent bottle at first passed described sealing-plug cuts the zone in advance, passes the plastic sheeting of airtight connection plastic bushing then.
When solvent bottle is screwed into airtight connection plastic bushing fully, convergent mouth of pipe wall contacts with the cavity wall of described sealing-plug, sealing-plug is in order to ensure the sealing fully between two containers, extruding plastic solvent bottle then, with solvent delivery to containing the lyophilization thing, in the tubular glass or plastic bottle of powder etc.Reorganization when lyophilized products, form end product and be when rocking device and finish, will install reversing then, make tubular glass or plastic bottle last, by pushing, decontrol the plastic solvent bottle more for several times, just the end product of reorganization can be recovered in the plastic solvent bottle.
According to another embodiment of the invention, the female thread portion inwall on airtight connection plastic bushing top has a collar flange as clamping piece, can make the sealing rubber plug location.
Be screwed in fully when airtight connection plastic bushing on the threaded cervical region of tubular glass or plastic bottle, and when contacting with the end face of described tubular glass or plastics bottleneck, elastic seal ring is used for guaranteeing sealing.
With reference to the accompanying drawings the preferred embodiments of the present invention are described.
Fig. 1 is the sketch map of expression shaped double tube bottle connecting device of the present invention.
Fig. 2 represents airtight connection plastic bushing.
Fig. 3 represents to have an elastic packing plug of cutting the zone in advance.
Fig. 4 represents to have the plastic sheeting of boring a hole of groove and weakness zone.
Fig. 5 represents shaped double tube bottle connecting device in accordance with another embodiment of the present invention.
Fig. 6 represents the airtight connection plastic bushing of another embodiment.
Fig. 7 represents the dual phial connecting device in the dry run.
Fig. 8 represents another embodiment in the dry run.
Fig. 9 represents clamp device.
Contain a kind of solids 2, for example a kind of lyophilization thing, powder etc. in tubular glass or the plastic bottle 1.In order to carry out the preparation of using solution, dry thing 2 must mix or dissolves with a kind of solvent 23, and solvent 23 is stored in separately in the plastic solvent bottle 3 of being made by flexible material.In order to mix or regrouping process, two containers 1 must be connected in such a way with 3, to such an extent as to solvent 23 can be imported in tubular glass or the plastic bottle 1, contain lyophilization thing 2 and mix and regrouping process in bottle 1.After rocking the solution in tubular glass or the plastic bottle 1, device is put upside down, made tubular glass or plastic bottle 1, by pushing and discharging described plastic solvent bottle 3 for several times, solution is input in the plastic solvent bottle 3 like this last.In this whole process, there are not fluid loss and leakage.
An airtight connection plastic bushing 4 is cylindrical, and comprise a lower internal thread part 5 and a upper internal threaded part 6, these two parts are isolated from each other by the plastic sheeting that can bore a hole 7 and come, and this thin film is and airtight plastic bushing 4 all-in-one-pieces that are connected.Just as will be explained below, in the connection procedure of two containers 1 and 3, plastic sheeting 7 can be pierced through by the convergent mouth of pipe 22 of plastic solvent bottle 3.
The convergent mouth of pipe 22 for the ease of plastic solvent bottle 3 passes, plastic sheeting 7 (Fig. 4) is provided with groove 8 in the middle, form specific weakness zone 32, when being screwed into the upper internal threaded part 6 of airtight connection plastic bushing 4, under the pressure of the convergent mouth of pipe 22 of plastic solvent bottle 3, zone 32 easier breaking.
Screw thread 24 on bottom 5 inwalls of airtight connection plastic bushing 4 matches with the reverse thread 25 of tubular glass or plastic bottle 1 cervical region.Below the female thread 24 of airtight connection plastic bushing 4 bottoms 5, on inner peripheral wall, be provided with a clamp device 30, this apparatus features is the tooth 9 of slight inclination, purpose is when touching the tubular glass that also has slight inclination tooth 11 or plastic bottle 1 cervical region, is convenient to tightening of airtight connection plastic bushing 4.After being screwed in airtight connection plastic bushing 4 on tubular glass or the plastic bottle 1, because cooperatively interacting of waveform tooth 9 and 11 can not be backed out airtight connection plastic bushing 4 from tubular glass or plastic bottle 1.
Sealing between airtight connection plastic bushing 4 and tubular glass or plastic bottle 1 cervical region end face is to guarantee by two features that match: to be columniform skirt section 12 extend downwards from the surface 7 of the plastic sheeting that can bore a hole for inner surface, and the external diameter that has an interior neck wall 10 with tubular glass or plastic bottle 1 to match.Interior columniform plastics skirt 12 is and airtight plastic bushing 4 all-in-one-pieces that are connected.Effectively second feature of sealing is an elastic seal ring 13, and it is arranged on the uppermost position in fig-ure place of cylindrical plastic skirt section 12 external surface peripherals 5 the insides, airtight connection plastic bushing 4 bottoms, that inwardly extend down.
There is an internal diameter on the top 6 of airtight connection plastic bushing 4 to hold plastic solvent bottle 3.For correct connection, the inwall on airtight connection plastic bushing 4 tops 6 is provided with screw thread 15, cooperates with reverse thread 14 on the plastic solvent bottle 3.
Below the female thread 15 on airtight connection plastic bushing 4 tops 6, be provided with a collar flange 16, be used as clamping piece and make sealing rubber plug 18 location.
On the upper periphery surface of the plastic sheeting 7 that can bore a hole, the top 6 and the bottom 5 of airtight connection plastic bushing 4 separated, one extends upward and is maintained at the position of described elastic packing plug 18 with cavity 19 columniform, the integrally formed plastic flange 17 that match, interior of elastic packing plug 18.Elastic packing plug 18 has a cavity 19 below in the middle, therefore can be as thin elastic film 20, and this thin film has the horizontal line of cutting in advance 21 (Fig. 3) in the middle.
When plastic solvent bottle 3 being screwed into the female thread portion 6 on airtight connection plastic bushing 4 tops, its convergent mouth of pipe 22 at first pass elastic packing plug 18 cut in advance the zone 21, pass the plastic sheeting 7 that to bore a hole then, and guaranteed sealing fully by contacting with the wall of cavities 19 in the elastic packing plug 18. Container 1 and 3 just is connected now, and by extruding and release plastic solvent bottle 3 several, the solvent 23 that comprises in the plastic solvent bottle 3 just is imported in the tubular glass or plastic bottle 1 that contains lyophilization thing 2.After the reorganization, device is put upside down, above tubular glass or plastic bottle 1 are positioned at,, solution is imported in the plastic solvent bottle 3 again by pushing again and discharging plastic solvent bottle 3 for several times.In the whole process without any spilling and leaking.
Another advantage of the present invention is the particular applicability of its dry run.Before the drying, a kind of active liquid 31 (Fig. 7) is housed in tubular glass or the plastic bottle 1.Airtight connection plastic bushing 4 is screwed on the screw thread 25 of tubular glass or plastic bottle 1 cervical region a little.The interior cylindrical plastic skirt section 12 that is arranged on bottom 5 in the airtight connection plastic bushing 4 is in this case, does not also contact with the interior neck wall 10 of tubular glass or plastic bottle 1.Tubular then glass or plastic bottle 1 and active liquid 31 thereof, and airtight connection plastic bushing 4 is placed into and carries out drying in the freeze dryer, sleeve 4 is not also screwed on fully.
(Fig. 2) as shown in FIG., the female thread 24 that is positioned at airtight connection plastic bushing 4 bottoms 5 is interrupted by vertical trench 28, and these grooves are as gas leakage or exhaust passage in the dry run, with the moisture that guarantees to exist with gaseous form or the discharge of liquid.After an exsiccant operating process was finished, airtight connection plastic bushing 4 was screwed on tubular glass or the plastic bottle 1 fully.These operating procedures can be carried out in full-automation.
Screw thread 25 following tooth 11 and the airtight teeth 9 that are connected plastic bushing 4 that are arranged on tubular glass or plastic bottle 1 cervical region cooperate, form clamp device 30 (Figure 10), its advantage is to prevent by manually-operated, when being screwed on tubular glass or the plastic bottle 1 fully, airtight connection plastic bushing 4 displacements.
Fig. 5,6 and 8 expression an alternative embodiment of the invention.In the description of these figure, same element is marked by same drawing reference numeral.In this another embodiment, there are some projectioies that are circular layout 26 bottom 5 of airtight connection plastic bushing 4 on the wall within it, limits internal diameter and is located between two annular protrusions 27 of tubular glass or plastic bottle 1 exterior.This structure has formed a kind of airtight connection plastic bushing 4 being connected on phial 1.
The wall of airtight connection plastic bushing 4 bottoms 5 extend to projection 26 below, form a kind of skirt section 29, with so that airtight connection plastic bushing 4 keeps position (Fig. 8) shown in the figure, this will describe below.
Identical with above-described embodiment, the sealing between airtight connection plastic bushing 4 and tubular glass or plastic bottle 1 cervical region is to realize by two features that cooperatively interact, i.e. inner skirt 12 and elastic seal ring 13.
Identical among the top 6 that airtight among the figure shown in (Fig. 5,6 and 8) is connected plastic bushing 4 and other embodiment (Fig. 1,2 and 7).
The feature of this another embodiment also is the particular applicability of its full-automatic dry run.Before the drying, a kind of active liquid 31 is housed in tubular glass or the plastic bottle 1.Airtight connection plastic bushing 4 is positioned at first protruding 27 tops of tubular glass or plastic bottle 1.Because the skirt section 29 of extending and the effect of projection 26, airtight connection plastic bushing 4 is not pushed down in the dry run, and sleeve 4 remains on the cervical region of tubular glass or plastic bottle 1.Tubular then glass or plastic bottle 1 and airtight connection plastic bushing 4, it is not pushed down, and is placed in to carry out drying in the freeze dryer.
Limit portion space between the projection that is circular layout 26 on airtight connection plastic bushing 4 bottoms 5 provide a tubular glass or plastic bottle 1 inner and on every side between the open type contact, guaranteed moisture or evaporation of liquid in the dry run like this.
After an exsiccant operating process was finished, airtight connection plastic bushing 4 was crushed on the tubular glass or plastic bottle 1 in the freeze dryer.These operating procedures can be carried out fully in full-automation.
With airtightly be connected that the projection that is circular layout on the plastic bushing 4 is 26 that cooperate, two projectioies 27 of special shape on tubular glass or the plastics bottleneck have additional advantage, also can prevent by manually-operated described airtight connection plastic bushing 4 displacements.
Claims (6)
1. shaped double tube bottle connecting device, be used for connecting two containers temporarily, normally tubular glass or plastic bottle and a plastic solvent bottle, its objective is a kind of desciccate and the reorganization of a kind of corresponding solvent, described dry thing is a kind of lyophilization thing that for example is contained in tubular glass or the plastic bottle, powder etc., corresponding solvent is contained in the plastic solvent bottle, connecting device has a columniform airtight connection plastic bushing, it has a bottom, this bottom has a clamp device inwardly, be connected with tubular glass or the reliable of plastic bottle cervical region in order to assurance, with a top, this top has female thread, in order to plastic solvent bottle and the all-in-one-piece plastic sheeting of being threaded, when the internal thread part timesharing that is screwed into airtight connection plastic bushing top, this thin film is pierced through by the convergent mouth of pipe of plastic solvent bottle
It is characterized in that airtight connection plastic bushing (4) has the thin film that can bore a hole (7), thin film (7) separates the upper internal threaded (6) of airtight connection plastic bushing (4) with bottom (5); An inner surface is columniform plastics skirt (12), be arranged on the interior bottom (5) of airtight connection plastic bushing (4), and extend downwards from the lower surface of the thin film (7) that can bore a hole, described skirt section has an external diameter to contact with the interior neck wall (10) of tubular glass or plastic bottle (1); An elastic seal ring (13) is installed in the uppermost position in fig-ure place of described skirt section (12) external surface peripheral; An elastic packing plug (18), the middle part has one and cuts a zone (21) and a cavity (19) in advance, described sealing-plug be arranged on a cylindrical flange (17) around, this flange is arranged on the internal upper part (6) of airtight connection plastic bushing (4), and extend upward from the upper surface of the thin film (7) that can bore a hole, and locate by annular projection (16), so the thin film (7) that can bore a hole, cylindrical skirt (12), flange (17) is the described airtight global formation parts that are connected plastic bushing (4) with annular projection (16).
2. connecting device as claimed in claim 1 is characterized in that being provided with in the interior bottom (5) screw thread (24), cooperates with the respective threaded (25) of tubular glass or plastic bottle (1) exterior.
3. connecting device as claimed in claim 2, it is characterized in that a clamp device (30), by tooth (9), this tooth of slight inclination be positioned at the lower inner wall peripheral part (5) of airtight connection plastic bushing (4) and be positioned at tubular glass or the screw thread of plastic bottle (1) (25) below the tooth (11) of slight inclination form.
4. connecting device as claimed in claim 2, it is characterized in that screw thread (24) is interrupted by vertical trench (28), when airtight connection plastic bushing (4) only partly is screwed on tubular glass or the plastic bottle (1), can keep from bottle the inside to the space of outside, with the evaporation of the moisture that guarantees to exist with gaseous form in the dry run.
5. connecting device as claimed in claim 1, the projection (26) of inside extension is arranged at the bottom that it is characterized in that airtight connection plastic bushing (4), be connected with the annular protrusion (27) that is positioned at around tubular glass or plastic bottle (1) exterior, limit portion space is arranged between the described annular protrusion (26), provide tubular glass or plastic bottle (1) inner with its around between open type contact, guaranteed the evaporation of the moisture that exists with gaseous form in the dry run like this.
6. connecting device as claimed in claim 5, it is characterized in that the wall of the bottom (5) of airtight connection plastic bushing (4) is provided with the extension (29) of skirt shape, described extension (29) with the projection (26) with so that in the dry run the airtight plastic bushing (4) that is connected be positioned on tubular glass or the plastic bottle (1), do not pushed down.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB971823340A CN1149063C (en) | 1997-08-27 | 1997-08-27 | Dual vial connecting system for lyophilized products |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB971823340A CN1149063C (en) | 1997-08-27 | 1997-08-27 | Dual vial connecting system for lyophilized products |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1259859A true CN1259859A (en) | 2000-07-12 |
| CN1149063C CN1149063C (en) | 2004-05-12 |
Family
ID=5178402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB971823340A Expired - Fee Related CN1149063C (en) | 1997-08-27 | 1997-08-27 | Dual vial connecting system for lyophilized products |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1149063C (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102190126A (en) * | 2010-03-12 | 2011-09-21 | 无锡可尚生物科技有限公司 | Storing and using method and device for soluble collagen |
| CN105377087A (en) * | 2013-04-26 | 2016-03-02 | 伊芙·巴兰伯斯 | Container coupler for transferring viscous liquids |
| CN106560096A (en) * | 2015-09-30 | 2017-04-12 | 李和伟 | Delivery and dissolving device of lyophilized excipient preparation |
| CN107042949A (en) * | 2016-02-05 | 2017-08-15 | 谢福鑫 | Independent storage mixing tank |
| CN107105865A (en) * | 2014-12-17 | 2017-08-29 | 株式会社爱茉莉太平洋 | It is internally formed foreign peoples's container for mixing liquid of bellows |
| CN107645944A (en) * | 2015-04-10 | 2018-01-30 | 东佩制药股份公司 | The distributor of eye drops |
| CN109715522A (en) * | 2017-03-23 | 2019-05-03 | 株式会社皇醋园 | Portable beverage container including quantitative package and locking cap |
| US11324630B2 (en) | 2016-06-30 | 2022-05-10 | Dompe' Farmaceutici S.P.A. | Controlled volume dropper |
-
1997
- 1997-08-27 CN CNB971823340A patent/CN1149063C/en not_active Expired - Fee Related
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102190126A (en) * | 2010-03-12 | 2011-09-21 | 无锡可尚生物科技有限公司 | Storing and using method and device for soluble collagen |
| CN105377087A (en) * | 2013-04-26 | 2016-03-02 | 伊芙·巴兰伯斯 | Container coupler for transferring viscous liquids |
| CN107105865B (en) * | 2014-12-17 | 2021-04-02 | 株式会社爱茉莉太平洋 | Heterogeneous liquid mixing container with corrugated pipe formed inside |
| CN107105865A (en) * | 2014-12-17 | 2017-08-29 | 株式会社爱茉莉太平洋 | It is internally formed foreign peoples's container for mixing liquid of bellows |
| US11103379B2 (en) | 2015-04-10 | 2021-08-31 | Dompe' Farmaceutici S.P.A. | Dispensing device for eye drops |
| CN107645944A (en) * | 2015-04-10 | 2018-01-30 | 东佩制药股份公司 | The distributor of eye drops |
| CN106560096A (en) * | 2015-09-30 | 2017-04-12 | 李和伟 | Delivery and dissolving device of lyophilized excipient preparation |
| CN107042949B (en) * | 2016-02-05 | 2019-04-09 | 谢福鑫 | independent storage mixing tank |
| CN107042949A (en) * | 2016-02-05 | 2017-08-15 | 谢福鑫 | Independent storage mixing tank |
| US11324630B2 (en) | 2016-06-30 | 2022-05-10 | Dompe' Farmaceutici S.P.A. | Controlled volume dropper |
| CN109715522A (en) * | 2017-03-23 | 2019-05-03 | 株式会社皇醋园 | Portable beverage container including quantitative package and locking cap |
| CN109715522B (en) * | 2017-03-23 | 2021-05-04 | 株式会社皇醋园 | Portable beverage container comprising a portion package and a retaining cap |
| US11383883B2 (en) | 2017-03-23 | 2022-07-12 | Royalgreens Co., Ltd. | Portable beverage container including portion pack and fixing cap |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1149063C (en) | 2004-05-12 |
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