CN1249933A - Veterinary parasiticidal paste containing Albendazole and its preparation - Google Patents
Veterinary parasiticidal paste containing Albendazole and its preparation Download PDFInfo
- Publication number
- CN1249933A CN1249933A CN 99119401 CN99119401A CN1249933A CN 1249933 A CN1249933 A CN 1249933A CN 99119401 CN99119401 CN 99119401 CN 99119401 A CN99119401 A CN 99119401A CN 1249933 A CN1249933 A CN 1249933A
- Authority
- CN
- China
- Prior art keywords
- albendazole
- paste
- surfactant
- ivermectin
- avilamycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
One kind of Albendazole cream with or without avermectin or ivermectin contains Albendazole 4-80 wt%, avermectin or ivermectin 0-4 wt%, stabilizer 0.1-20 wt%, surfactant 0-50 wt% other than dispersant. The ratio between Albendazole and avermectin or ivermectin is 25-100 to 1 with the optimal ratio being 50 to 1. The cream of the present invention is low in production cost and easy to use.
Description
The present invention is a kind of anti-parasite medicine for animal use, more particularly, is a kind of veterinary antiparasitic paste that contains albendazole (Albendazole) and preparation method thereof.
Albendazole is as the existing history for a long time of anthelmintic for animals, and domestic mainly is that to be made into tablet oral, uses very inconvenient.We develop a kind of albendazole paste or albendazole and avilamycin (Abamectin, Avermectin B
1) or the compound recipe paste of ivermectin (Ivermectin), production cost is low, and is very easy to use, is a kind of novel form that is worth promoting.
The purpose of this invention is to provide a kind of veterinary antiparasitic paste that contains albendazole and preparation method thereof.
The described preparation method that contains the albendazole paste is: (1) grinds well stabilizing agent and dispersant; (2) will disperse with dispersant through the albendazole powder (compound preparation adds avilamycin or ivermectin) of micronizing, mix, add an amount of surfactant, grind with colloid mill with (1); (3) stick with paste with paste producing mechanism, the degassing, further mixing, the paste can packing machine of packing into, canned in plastic tube.
Described paste prescription is formed (by weight percentage): albendazole 4-80%, and avilamycin or ivermectin 0-4%, stabilizing agent 0.1-20%, surfactant 0-50%, all the other are dispersant.When albendazole and avilamycin or ivermectin were composite, proportion was 25: 1-100: 1, and best proportioning is 50: 1.
Described albendazole is a kind of anthelmintic of broad-spectrum high efficacy, to nematicide, trematodiasis, cestode effectively (one one of People's Republic of China's veterinary drug allusion quotation one nine nine zero year version, P33-34).
Described avilamycin is the metabolite of A Foman streptomycete Streptomyces avermitilis, is A by eight structures
1a, A
1b, A
2a, A
2b, B
1a, B
1b, B
2a, B
2bHomologue form B commonly used
1aAnd B
1bMixture (William C.Campbell, " Ivermectinand Abamectin ", 1989, P1-23).
Described ivermectin be avilamycin two hydroperoxide derivatives (William C.Campbell, " Ivermectin and Abamectin ", 1989, P1-23).
Described stabilizing agent comprises carboxymethyl cellulose, xanthan gum, arabic gum, hydroxy methocel, carboxyethyl cellulose, gelatin, polyvinyl alcohol, agar etc.
Described surfactant comprises anion surfactant, as sulfuric acid, carboxylate, lead ethyl xanthate hydrochlorate, phosphate ester salt; Cationic surfactant is as amine salt type cation surface activating, quaternary ammonium salt cationic surfactant; Non-ionic surface active agent is as polyethylene glycol type, Tweens, polyoxyethylene aliphatic alcohol ether, polyethenoxy alkylphenols, polyvinylpyrrolidone; Amphoteric surfactant is as aminoacid amphoteric surfactant, betaine type amphoteric surfac-tant, imidazoline type amphoteric surfactant, amine oxide.
Described dispersant comprises glycerol, vegetable oil (comprising Semen Maydis oil, Oleum sesami, Oleum Glycines, rapeseed oil, persimmon oil, Oleum Arachidis hypogaeae semen, Oleum Helianthi, almond oil), mineral oil, 1,2-propylene glycol, ethanol, azone or water, these dispersants can use separately, also can two or more mix use.
Albendazole paste of the present invention is more easy to use than the tablet of common usefulness, and very economical, the compound recipe paste of making after composite with avilamycin or ivermectin and albendazole, strengthened drug effect, enlarge insecticidal spectrum, promptly can kill entozoa, also can kill epizoa.
Further describe feature of the present invention below, but example does not limit the scope of right protection with example.It only is the part in the right protection scope.
Example 1:
This example is the paste of preparation albendazole 10%.
With 5 kilograms of arabic gums and 40 liters of distilled water mixings, soaked overnight grinds well.After will disperseing with 5 kilograms of glycerol through the albendazole 11 kilograms (purity is 90%) of micronizing, mix, add 40 liters of Tween-80, grind with colloid mill with gumwater.Stick with paste with paste producing mechanism then, the degassing, further mixing, the tank filling installation is canned in plastic tube.
Example 2:
This example is the paste that preparation contains albendazole 70%.
With 0.2 kilogram of xanthan gum and 12 liters of distilled water mixings, soaked overnight, grind well, will be through the albendazole 77 kilograms (purity is 90%) of micronizing with 10 liter 1, the 2-propylene glycol mixes with xanthan gum solution after disperseing, add 0.5 liter of Tween-20, grind with colloid mill, with paste producing in the example 1, canned then.
Example 3:
This example is that preparation contains albendazole 30%, the compound recipe paste of avilamycin 0.6%.
With 0.5 kilogram of carboxymethyl cellulose and 26 liters of distilled water mixings, soaked overnight, grind well, will be through 33 kilograms of the albendazoles of micronizing, after 30 liters of Oleum sesami of 0.66 kilogram of usefulness of avilamycin disperse, mix with cmc soln after adding 10 liters of Span-80, grind paste producing later on example 1 method.
Example 4:
This example is that preparation contains albendazole 60%, the compound recipe paste of ivermectin 0.6%.
With 10 liters of distilled water mixings, soaked overnight grinds well with 1 kilogram of gelatin, will be through 66 kilograms of the albendazoles of micronizing, after 21 liters of distilled water of 0.6 kilogram of usefulness of ivermectin disperse, after gelatin solution mixes, add 1 liter of Tween-80 mixing, with the method paste producing of example 1.
Example 5:
This example is done the comparison of drug effect with paste of the present invention and conventional albendazole tablet and avilamycin or the agent of ivermectin list, the results are shown in Table 1.
Table 1 albendazole paste is to the parasitic repelling and killing efficacy comparison sheet of sheep
| Project | Albendazole (mg/kg) | Avilamycin (mg/kg) | Drug effect (%) | ||||
| Trichostrongyle | The oersted nematicide | Moniezia | No vitellarium cestode | Acaricide | |||
| The albendazole tablet | ????10 | ????0 | ??97.5 | ????96.7 | ????91.6 | ????94.8 | ??0 |
| Abamectin injection | ????- | ????0.2 | ??100 | ????100 | ????0 | ????0 | ??96.9 |
| Albendazole paste in the example 1 | ????10 | ????- | ??96.9 | ????97.2 | ????96.1 | ????97.1 | ??0 |
| Albendazole in the example 3 and avilamycin compound formulation | ????10 | ????0.2 | ??100 | ????100 | ????100 | ????98.2 | ??96.3 |
Claims (6)
1, a kind of veterinary antiparasitic paste that contains albendazole, specifically form content and be: albendazole 4-80%, stabilizing agent 0.1-20%, surfactant 0-50%, all the other are dispersant.
2, a kind of compound recipe paste that is made into albendazole and avilamycin or ivermectin.The concrete composition or content: albendazole 4-80%, avilamycin or ivermectin 0.1-4%, stabilizing agent 0.1-20%, surfactant 0-50%, all the other are dispersant.
3, compound recipe paste according to claim 2 is characterized in that avilamycin or ivermectin and the content of albendazole are 1 than scope: 25-1: 100, and the best is joined and is turned to 1: 50.
4, paste according to claim 1 and 2 is characterized in that described stabilizing agent comprises carboxymethyl cellulose, xanthan gum, arabic gum, hydroxy methocel, carboxyethyl cellulose, gelatin, polyvinyl alcohol, agar etc.
5, paste according to claim 1 and 2 is characterized in that described surfactant comprises anion surfactant, cationic surfactant, non-ionic surface active agent and amphoteric surfactant.
6, paste according to claim 1 and 2 is characterized in that described dispersant comprises glycerol, vegetable oil, mineral oil, 1, and 2-propylene glycol, ethanol, azone or water, these dispersants can use separately, also can two or more compound use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99119401 CN1249933A (en) | 1999-09-21 | 1999-09-21 | Veterinary parasiticidal paste containing Albendazole and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99119401 CN1249933A (en) | 1999-09-21 | 1999-09-21 | Veterinary parasiticidal paste containing Albendazole and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1249933A true CN1249933A (en) | 2000-04-12 |
Family
ID=5280883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99119401 Pending CN1249933A (en) | 1999-09-21 | 1999-09-21 | Veterinary parasiticidal paste containing Albendazole and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1249933A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751201A (en) * | 2014-01-03 | 2014-04-30 | 聊城大学 | Anti-parasitic orally disintegrating tablet for dogs and cats and preparation method thereof |
| CN108125971A (en) * | 2016-11-30 | 2018-06-08 | 黎凯华 | A kind of ivermectin composition insecticidal preparation |
-
1999
- 1999-09-21 CN CN 99119401 patent/CN1249933A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751201A (en) * | 2014-01-03 | 2014-04-30 | 聊城大学 | Anti-parasitic orally disintegrating tablet for dogs and cats and preparation method thereof |
| CN108125971A (en) * | 2016-11-30 | 2018-06-08 | 黎凯华 | A kind of ivermectin composition insecticidal preparation |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1610613B1 (en) | Topical anthelmintic veterinary formulations | |
| TWI498122B (en) | Aqueous pharmaceutical compositions containing borate-polyol complexes | |
| DE69922296T2 (en) | ANTIBACTERILLE COMPOSITION FOR TOPICAL APPLICATION, CONTAINING FAROPENEM | |
| EP2348832B1 (en) | Preservative system for emulsion-based therapeutic topical formulations | |
| CH683823A5 (en) | A topical, allylamine-containing formulation. | |
| ZA200206484B (en) | Improved paste formulations. | |
| EP3182957B1 (en) | Cineole-containing composition for nasal application | |
| EP0697814B1 (en) | Pour-on formulations containinng polymeric material, glycols and glycerides | |
| EP2104426B1 (en) | Agents for controlling parasites on animals | |
| EP2191820B1 (en) | Pharmaceutical formulations of meloxicam | |
| CN112868662A (en) | Low-temperature efficient compound disinfectant and preparation method thereof | |
| CA2487648A1 (en) | Pharmaceutical preparations for oral administration, containing ion-exchange resins loaded with active ingredients and intrinsically viscous gelling agents as thickening agents | |
| KR20120032459A (en) | Topical composition | |
| EP1197215B1 (en) | Anthelmintic compositions | |
| CN1249933A (en) | Veterinary parasiticidal paste containing Albendazole and its preparation | |
| WO2003017976B1 (en) | Synergistic mixed poloxamer systems for the solubilisation of drugs | |
| US5516761A (en) | Pour-on formulations containing polymeric material | |
| ES2846820T3 (en) | Composition of macrocyclic lactones, levamisole, an amino sugar and an additional antiparasitic agent | |
| KR20120120376A (en) | Topical antiparasitic formulations | |
| CN1304727A (en) | Injection containing evericin or ivermectin and using benzyl benzoate or nitrone as co-solvent | |
| CN101167458A (en) | Bactericide agent composition containing propiconazol effective component and use thereof | |
| CN1044440C (en) | Animal anti-parasite oral liquor containing avilamycin or envimycin | |
| CN103006559A (en) | Doramectin injection and preparation method thereof | |
| CN107136109A (en) | A kind of emamectin benzoate adds lufenuron suspension agent formula, preparation method and application method | |
| JP2001131055A (en) | Liquid agent, removal of white cloudiness of liquid agent and acceleration of trans-mucous membrane absorption of liquid agent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |