CN1246687C - Device for combining point light source with single lens - Google Patents
Device for combining point light source with single lens Download PDFInfo
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- CN1246687C CN1246687C CN 03100945 CN03100945A CN1246687C CN 1246687 C CN1246687 C CN 1246687C CN 03100945 CN03100945 CN 03100945 CN 03100945 A CN03100945 A CN 03100945A CN 1246687 C CN1246687 C CN 1246687C
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- light
- light source
- lens
- single lens
- binding site
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Abstract
The present invention relates to a device for combining a point light source with a single lens, which mainly comprises the point light source, a light sensor and the lens, wherein the lens is arranged on the same sides of the point light source and the light sensor so that the emitted light of the point light source is focused through the lens on an object which is to be measured and the reflection light which passes through the object which is to be measured is focused on the light sensor through the lens. The content of a specific component which is to be measured is determined qualitatively and quantificationally through the device of the present invention, and the measurement resolution can be enhanced through the combination relation of the point light source, the light sensor and the single lens.
Description
(1) technical field
The relevant a kind of device that detects determinand of the present invention with little area of detection; Particularly about the device of a kind of binding site light source and single lens.
(2) background technology
For chemistry and biological chemistry composition in the colour developing waterborne liquid quantitatively, particularly develop the color biofluid for example in blood, urine and biofluid derivant such as serum and the blood plasma chemistry and biological chemistry composition quantitatively, more and more important.Many important use have been present in medical diagnosis and the treatment, and on medicine for treatment thing, toxicity article and harmful chemical etc. quantitative.In some applications, need quantitative its concentration of material often in milligram/per 100 cubic centimeters of scopes or following and too micro-, so that very difficult quantitative exactly, perhaps need to use complicated instrument and adept operating personnel.In addition, in such cases, after sampling, could obtain analysis result after a few hours or several days usually.
It is diabetic's blood-sugar content measurement that a kind of common medical treatment detects.The practice now is the suggestion diabetic according to the individual state of an illness in one day interior measuring blood content two to seven times.Diabetic and doctor adjust diabetic's diet, motion and insulin injection amount again according to the blood-sugar content measurement result, with effective control of diabetes state of an illness.
Widely used now a kind of blood-sugar content detection method is to adopt a kind of inspection test piece, blood sample (about 20 to 40 microlitres) bestowed at inspection test piece being coated with on the reagent pad of ethyl cellulose, this reagent pad contains the ferment system that comprises glucose oxidase (glucose oxidase) and peroxidase (peroxidase).This meeting of ferment system and glucose response produce hydrogen peroxide.The reagent pad still contains a kind of indicator, and it is under the situation that peroxidase exists, and meeting and hydroperoxidation produce the proportional substance that show color of concentration of glucose in colored intensity and the blood sample.Another kind of blood-sugar content detection method is to adopt identical chemical principle, but replaces being coated with the reagent pad of ethyl cellulose with waterproofing membrane, and wherein ferment composition and indicator are to intersperse among in the waterproofing membrane.
In above-mentioned two kinds of known blood-sugar content detection methods, blood sample is to contact a schedule time with the reagent pad, approximate number minute.Then, with regard to above-mentioned first kind of known method, be with clear water with blood sample eccysis from the reagent pad, and, be that blood sample is wiped away from the reagent pad with regard to above-mentioned second kind of known method.Then, the reagent pad is blotted and measures.This assay method is that the colored intensity of reagent pad and a color table (color chart) are compared, or inspection test piece is placed a reflectance measurement instrument, with the colored intensity value on the reading reagent pad.
Though more than the row year, these methods all have its restriction, for example in the detection that said method is used in blood-sugar content, take a sample with the acupuncture finger tip, all need bigger sample detection area, for blood capillary manifested unconspicuous people, difficulty obtained enough blood samples.
The quantitative result of above-mentioned known detection method is the colored intensity value of relying in being read, and this colored intensity value is relevant with the extent of reaction of detectable on blood sample and the reagent pad.First kind of known method is after one section predetermined reaction time, need blood sample eccysis or wipe away from the reagent pad, so the user need prepare after the predetermined reaction time, with the blood sample on the clear water wash-off agents pad or wipe blood sample away.Blood sample is removed the reaction that can stop the detectable on blood sample and the reagent pad from the reagent pad, the uncertainty that causes testing result, excessively cleaning may obtain lower testing result, clean and then may obtain the higher detection result inadequately, for the user who uses at home voluntarily, more shape is obvious for this problem.
Another problem is when blood sample is bestowed on the reagent pad, promptly needs to start a time sequence.The user obtains blood sample with the method for acupuncture finger tip usually, and the user need use the another hand to start timer when blood sample being bestowed on the reagent pad.Therefore, above-mentioned known detection method needs the user to make with the hands simultaneously.Owing to must guarantee when blood sample is bestowed at the reagent pad, just to start timer, make the user on behaviour does, become difficult.
In view of the above, demand providing a kind of for example device of specific component content in the blood sample of colour developing liquid that detects urgently, it can overcome the disappearance of known detection method.
(3) summary of the invention
Fundamental purpose of the present invention provides the device of a kind of binding site light source and single lens, and it can detect the determinand of point-like or the little area of detection of tool.
Another object of the present invention provides the device of a kind of binding site light source and single lens, and it is to meet light, thin, short, little and miniaturization demand, and carries easily.
Another purpose of the present invention provides the device of a kind of binding site light source and single lens, and wherein lens have spotlight effect, and do not need the light emitting source of high luminous intensity.
A further object of the present invention provides the device of a kind of binding site light source and single lens, and its combined member reaches simply less, makes easily, can save manufacturing cost.
Another purpose again of the present invention provides the device of a kind of binding site light source and single lens, and it can be used for qualitative and detects the specific composition that the district is checked in one of a test piece quantitatively.
The present invention again again a purpose provide the device of a kind of binding site light source and single lens, it can be used for detecting a specific composition in the quality testing body in all one's life, and easy operating, is beneficial to the user and detects voluntarily.
Of the present invention again again a purpose provide the device of a kind of binding site light source and single lens, it can improve the measurement sharpness by the spotlight effect of lens.
The device of a kind of binding site light source and single lens comprises: a pointolite; One optical sensor; And lens, be the homonymy of being located at this pointolite and this optical sensor so that the emission light of this pointolite via this lens focus in a determinand, and the reflected light that makes this determinand via this lens focus in this optical sensor; Described determinand is a test piece that comprises a light absorption area, and this light absorption area is that this light absorption area can absorb this emission light of this pointolite by a specific composition generation of a tested corpse or other object for laboratory examination and chemical testing that is administered to this test piece; Be characterized in: described pointolite can be launched one first wavelength light and one second wavelength light, wherein this first wavelength light is to be absorbed by this tested corpse or other object for laboratory examination and chemical testing that this light absorption area of this test piece comprises, reach with the intensity of this first wavelength light that reflects through this light absorption area, bestow sampling amount with decision at this tested corpse or other object for laboratory examination and chemical testing of this test piece, and this second wavelength is by this light absorption area absorption that should specific composition produces that mutually should a tested corpse or other object for laboratory examination and chemical testing, reach with the intensity of this second wavelength light that reflects through this light absorption area, to determine the concentration of this specific composition.
Lens have the secondary condensation effect, and the syntagmatic of mat pointolite, optical sensor and lens can improve the measurement sharpness of apparatus of the present invention.
The device of binding site light source provided by the invention and single lens, it is formed member and reaches less simply, can save to take up space and be convenient for carrying, and can reduce manufacturing cost.
Purpose of the present invention and plurality of advantages be by the detailed description of following specific embodiment, and graphicly will more be tending towards clear with reference to appended.
(4) description of drawings
Fig. 1 is the perspective diagram of a test piece; And
Fig. 2 is the function block schematic diagram that comprises a smooth reflectance measurement instrument of the present invention's one preferred embodiment.
(5) embodiment
The invention provides the device of a kind of binding site light source and single lens, it mainly comprises a pointolite, an optical sensor and lens.Lens are homonymies of being located at pointolite and optical sensor so that the emission light of pointolite via lens focus in a determinand, and make reflected light through determinand via lens focus in optical sensor.Apparatus of the present invention can be for making a smooth reflectance measurement instrument, and it can be applicable to detect the determinand of tool point-like area of detection or little area of detection, and mat is measured the intensity of reflected light through the determinand reflection, with the content of a specific composition in the decision determinand.Apparatus of the present invention can be in order to measuring the intensity of reflected light of the color development area on the inspection test piece, and by the intensity of reflected light that records, with the content of decision specific composition in a tested corpse or other object for laboratory examination and chemical testing of inspection test piece test.
With reference to Fig. 1, be test piece 10 perspective diagrams of a specific composition in a kind of detection one tested corpse or other object for laboratory examination and chemical testing.Test piece 10 comprises a strip base material 12 and a reagent pad 14.Reagent pad 14 is a test surfaces (test surface) ends that stick in strip base material 12 with a kind of adhesive agent (adhesive) 16.Reagent pad 14 comprises a ferment system and an indicator (indicator), and wherein the ferment system contains and can make this specific composition in the tested corpse or other object for laboratory examination and chemical testing react with the oxidase that produces hydrogen peroxide and make hydrogen peroxide and peroxidase that indicator reacts.Peroxidase in the ferment system is to make hydrogen peroxide and indicator reaction to produce the colour developing extinction material.The one sample face (sample surface) of strip base material 12 relative its test surfaces is provided with an opening 18, and the tested corpse or other object for laboratory examination and chemical testing of confession from then on opening 18 is bestowed on reagent pad 14.When the ferment system of reagent pad 14 contains glucose oxidase and peroxidase, the glucose of bestowing in the blood sample of reagent pad 14 through the opening 18 of sample face produces hydrogen peroxide through the glucose oxidase enzymic catalytic reaction, and under peroxidase catalysis, hydrogen peroxide and indicator reaction produce the colour developing extinction material, are formed at an opposite side of reagent pad 14 corresponding strip base material 12 test surfaces.Concentration of glucose in the blood sample then is proportional to the colored intensity of colour developing extinction material.This colour developing extinction material can change the light reflection strength of reagent pad 14, and the intensity of reflected light with measuring the colour developing extinction material then can determine the concentration of glucose in the blood sample.When the ferment system of reagent pad 14 contained cholesterol oxidase, it can make cholesterol carry out catalytic reaction and produce hydrogen peroxide, and test piece 12 can be in order to detect the cholesterol level in the blood sample.Therefore, with the ferment system composition that changes test piece 12, can determine the specific composition of a detectable tested corpse or other object for laboratory examination and chemical testing.In addition, the light reflection strength of the colour developing extinction material on the reagent pad 14 be with a tested corpse or other object for laboratory examination and chemical testing in the concentration relation of being inversely proportional to of a specific composition, the light reflection strength of the colour developing extinction material on the device detectable pad 14 of binding site light source of the present invention and single lens can determine the concentration of this specific composition in the tested corpse or other object for laboratory examination and chemical testing.
Below will describe apparatus of the present invention and application thereof in detail by preferred embodiment.
With reference to Fig. 2, it is the function block schematic diagram that comprises a smooth reflectance measurement instrument of the present invention's one preferred embodiment, and present embodiment comprises a retaining piece 21, a pointolite 22, an optical sensor 23, lens 24, an amplifier 25, an analog-digital converter 26, a microprocessor 27, a storer and a display 29.Pointolite 22 is one first ends of being located at retaining piece 21, and optical sensor 23 is one second ends of being located at the retaining piece 21 of the first end homonymy.Lens 24 are homonymies of being located at pointolite 22 and optical sensor 23, use the emission light that makes pointolite 22 focuses on a determinand 30 that is positioned at lens 24 opposite sides via lens 24 a light absorption area 31.In the present invention, determinand 30 is preferably the focal position that is positioned at lens 24.The reflected light of the light absorption area 31 of determinand 30 focuses on optical sensor 23 via lens 24 again.The light absorption area 31 of determinand 30 comprises a colour developing extinction material, but the emission light of absorption point light source 22.The colored intensity of this colour developing extinction material is proportional with a specific component content number that produces this colour developing extinction material, and makes this colour developing extinction material for the specific therewith composition relation of being inversely proportional to of the light reflection strength of pointolite 22.Refer again to Fig. 1, determinand 30 promptly can be the test piece 10 that comprises a light absorption material, and this light absorption material is the specific composition generation by a tested corpse or other object for laboratory examination and chemical testing that is administered to test piece 10.Optical sensor 23 is that the reflected light of corresponding light absorption area 31 through determinand 30 produces a kinetic current.In this preferred embodiment, pointolite 22 can be a light emitting diode (lightemitting diode), and 23 of optical sensors can be a photodiode (photodiode), a charge coupled cell (charge-coupled device) and a CMOS (Complementary Metal Oxide Semiconductor) sensor (Complementary Metal-Oxide-Semiconductor sensor).
The induction current that the optical sensor 23 corresponding intensities of reflected light that reflect through the light absorption area 31 of determinand 30 produce is via an amplifier 25, convert a voltage to, convert the set of number signal to via an analog-digital converter 26 again, deliver to a microprocessor 27 then.Microprocessor 27 can provide following function: timing is carried out in the measurement for light reflectance measurement instrument; Read the digital signal of analog-digital converter 26 outputs; In conjunction with an executive routine that is stored in storer 28, calculating the light reflection strength value of a sampling time point, and this light reflection strength value is stored in storer 28; According to the light reflection strength value that stores, with a specific components and concentration value of the light absorption area 31 that determines corresponding determinand 30.This concentration value again via a display 29 for example liquid crystal display displays come out.
In another preferred embodiment of the present invention, except pointolite, all the other form member, and all the member with shown in Figure 2 is identical, pointolite 22 is to be designed to launch one first wavelength light and one second wavelength light, wherein the first wavelength light can be absorbed by the tested corpse or other object for laboratory examination and chemical testing that the light absorption area 31 of determinand 30 comprises, whether and mat is through the intensity of the first wavelength light of light absorption area 31 reflection, can determine to bestow at the sampling amount of the tested corpse or other object for laboratory examination and chemical testing of determinand 30 enough.For example when bestowing when the tested corpse or other object for laboratory examination and chemical testing sampling amount of the light absorption area 31 of determinand 30 is enough, the light reflection strength that then can measure the first wavelength light only has a little when not bestowing a tested corpse or other object for laboratory examination and chemical testing and reduces, when for example the light reflection strength of the first wavelength light is not less than a predetermined value, analog-digital converter 26 can be sent a bit digital signal " 0 " to microprocessor 27, send a caution signal by microprocessor 27 again, to remind the tested corpse or other object for laboratory examination and chemical testing sampling amount of user deficiency.When bestowing when the tested corpse or other object for laboratory examination and chemical testing sampling amount of the light absorption area 31 of determinand 30 is enough, the light reflection strength that then can measure first wavelength has tangible reduction when not bestowing a tested corpse or other object for laboratory examination and chemical testing, for example the light reflection strength of the first wavelength light is lower than this predetermined value, and this moment, analog-digital converter 26 can be sent a bit digital signal " 1 " to microprocessor 27.Microprocessor 27 then reference mark light source 22 sends the second wavelength light, focus on the light absorption area 31 of determinand 30 through lens 24, the second wavelength light is a colour developing light absorption material absorbing that can be comprised by light absorption area 31, and this colour developing light absorption material is that a specific composition causes in the tested corpse or other object for laboratory examination and chemical testing.Intensity by the second wavelength light of light absorption area 31 reflection can determine this specific components and concentration.
The device of binding site light source provided by the invention and single lens can be applicable to a smooth reflectance measurement instrument, and wherein lens have the secondary condensation effect, can improve the measurement sharpness of this light reflectance measurement instrument.Apparatus of the present invention member reaches simply less, except can reaching the purpose that reduces manufacturing cost, also meets demand light, thin, short, little, miniaturization, makes things convenient for the user to carry.
The above only is specific embodiments of the invention, and it is not in order to limit claim of the present invention; All other do not break away from equivalence change or the equivalence replacement that disclosed spirit is finished, and all should be included in the following claim institute restricted portion.
Claims (9)
1. the device of binding site light source and single lens comprises:
One pointolite;
One optical sensor; And
One lens are homonymies of being located at this pointolite and this optical sensor so that the emission light of this pointolite via this lens focus in a determinand, and the reflected light that makes this determinand via this lens focus in this optical sensor; Described determinand is a test piece that comprises a light absorption area, and this light absorption area is that this light absorption area can absorb this emission light of this pointolite by a specific composition generation of a tested corpse or other object for laboratory examination and chemical testing that is administered to this test piece; It is characterized in that:
Described pointolite can be launched one first wavelength light and one second wavelength light, wherein this first wavelength light is to be absorbed by this tested corpse or other object for laboratory examination and chemical testing that this light absorption area of this test piece comprises, reach with the intensity of this first wavelength light that reflects through this light absorption area, bestow sampling amount with decision at this tested corpse or other object for laboratory examination and chemical testing of this test piece, and this second wavelength is by this light absorption area absorption that should specific composition produces that mutually should a tested corpse or other object for laboratory examination and chemical testing, reach with the intensity of this second wavelength light that reflects through this light absorption area, to determine the concentration of this specific composition.
2. the device of binding site light source as claimed in claim 1 and single lens is characterized in that, also comprises a retaining piece, is used to set firmly this pointolite in one first end of this retaining piece and set firmly one second end of this optical sensor in this retaining piece.
3. the device of binding site light source as claimed in claim 1 and single lens is characterized in that, described determinand is a focal position that is positioned at these lens.
4. the device of binding site light source as claimed in claim 1 and single lens is characterized in that described pointolite comprises a light emitting diode.
5. the device of binding site light source as claimed in claim 1 and single lens is characterized in that, described optical sensor is that corresponding reflected light through this determinand produces an induction current.
6. the device of binding site light source as claimed in claim 5 and single lens is characterized in that, described optical sensor is to be selected from one of photodiode, charge coupled cell and CMOS (Complementary Metal Oxide Semiconductor) sensor.
7. the device of binding site light source as claimed in claim 1 and single lens is characterized in that, this specific composition of this tested corpse or other object for laboratory examination and chemical testing that described test piece detects is the ferment system decision that is comprised by this test piece.
8. the device of binding site light source as claimed in claim 7 and single lens is characterized in that, described test piece is in order to detect the concentration of glucose of a blood sample.
9. the device of binding site light source as claimed in claim 7 and single lens is characterized in that, described test piece is in order to detect the cholesterol level of a blood sample.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03100945 CN1246687C (en) | 2003-01-07 | 2003-01-07 | Device for combining point light source with single lens |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03100945 CN1246687C (en) | 2003-01-07 | 2003-01-07 | Device for combining point light source with single lens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1515891A CN1515891A (en) | 2004-07-28 |
| CN1246687C true CN1246687C (en) | 2006-03-22 |
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ID=34239007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03100945 Expired - Fee Related CN1246687C (en) | 2003-01-07 | 2003-01-07 | Device for combining point light source with single lens |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1246687C (en) |
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2003
- 2003-01-07 CN CN 03100945 patent/CN1246687C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1515891A (en) | 2004-07-28 |
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| C06 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: YUXI SCIENCE CO., LTD. Free format text: FORMER OWNER: YUDONG TECHNOLOGY CO., LTD. Effective date: 20090814 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20090814 Address after: Delaware Patentee after: Transpacific IP Pte Ltd. Address before: Taipei City, Taiwan, China Patentee before: Transpacific IP Pte Ltd. |
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| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060322 Termination date: 20110107 |