CN1243704A - Quickly-acting analgesic - Google Patents
Quickly-acting analgesic Download PDFInfo
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- CN1243704A CN1243704A CN 98116986 CN98116986A CN1243704A CN 1243704 A CN1243704 A CN 1243704A CN 98116986 CN98116986 CN 98116986 CN 98116986 A CN98116986 A CN 98116986A CN 1243704 A CN1243704 A CN 1243704A
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- rotundine
- analgesic
- quickly
- class
- smooth muscle
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A quick-acting analgesic includes two compound preparations. One for treating aseptic inflammation and closed injury of neck, shoulder, back, lumbus and extremities is prepared from rotundine and antipyretic analgesics. Another for treating pain caused by visceral smooth muscle spasm is prepared from rotundine and M receptor blocker. Its advantages are good analgesic effect and no obvious by-effect.
Description
The present invention is a class analgesic.
At present, the analgesia of clinical practice (pain relieving) medicine has: 1) opiates (is representative with the morphine); 2) analgesic of synthetic (is representative with the pethidine); 3) analgesic that from Chinese medicine, extracts (as rotundine, tetrahydropalmatine); 4) antipyretic analgesic; 5) m receptor blocker (being used for the treatment of the pain that the visceral smooth muscle spasm causes).Though these medicines respectively have its advantage, its shortcoming is also respectively arranged: medicine analgesic effects such as morphine, pethidine are good, cause side effect such as dizzy, vomiting, addiction but have; Medicine such as rotundine, tetrahydropalmatine analgesic activity is better than antipyretic analgesic, have no side effect, but can not antiinflammatory, rheumatism, releasing smooth muscle spasm; The antiinflammatory of antipyretic analgesic energy, rheumatism, but its analgesic effect is not as good as rotundine and tetrahydropalmatine; Thereby the m receptor blocker can be removed the visceral smooth muscle spasm and ease the pain, but its analgesic effect is also not as good as rotundine and tetrahydropalmatine.Still there is not a class analgesic activity strong (surpassing the rotundine class) at present, again can antiinflammatory, rheumatism or remove smooth muscle spasm, and do not have the medicine of significant side effects.
The objective of the invention is for a class analgesic is provided, its analgesic activity surpasses the rotundine class, again can antiinflammatory, rheumatism or remove the visceral smooth muscle spasm, and do not have significant side effects.
The present invention realizes above-mentioned purpose like this: (one) is with rotundine class and the compatible compound preparation of making of antipyretic analgesic, wherein rotundine is brought into play analgesic activity at maincenter, antipyretic analgesic is brought into play analgesic activity in periphery, so its comprehensive analgesic activity is all better with antipyretic analgesic with rotundine and list than single, and can bring into play antiinflammatory, the anti rheumatism action of antipyretic analgesic; (2) with rotundine class and the compatible compound preparation of making of m receptor blocker, wherein rotundine is brought into play analgesic activity at maincenter, the m receptor blocker is removed the visceral smooth muscle spasm and is brought into play analgesic activity in periphery, so the comprehensive analgesic effect of the pain that it causes the internal organs smooth muscle spasm, than single with rotundine and single all good with the m receptor blocker.
Be described further below in conjunction with embodiment.
Embodiment 1 (No. 1, quickly-acting analgesic)
Dosage form and composition: tablet, every contains rotundine 60mg, indometacin 30mg, vitamin B
610mg.
Cure mainly: the aseptic inflammation at positions such as neck, shoulder, waist, extremity and closed injury (as cervical spondylosis, scapulohumeral periarthritis, neck shoulder back fibrositis, brachial plexus neuralgia, external humeral epicondylitis, tenosynovitis, psoas muscle fibrositis, lumbar muscle strain, lumbar sprain, prolapse of lumbar intervertebral disc, lumbar vertebra hyperosteogeny, sciatica, rheumatic arthritis, rheumatoid arthritis, osteoarthritis etc.) also can be used for general headache.
Usage and consumption: oral, each 1--2 sheet, every day 2--4 time.
The side separates: in the above prescription, rotundine can be brought into play analgesic activity at nervus centralis, and can blood circulation promoting and blood stasis dispelling, circulation of qi promoting; Indometacin can weaken the stimulation to the tip chemoreceptor of active substance that inflammation produces, at periphery performance analgesic activity.These two kinds of medicines are compatible, and its comprehensive function is at two links performances of maincenter and periphery analgesic activity (its analgesic activity is better than single with rotundine and single indometacin of using), and can invigorate blood circulation, blood stasis dispelling, circulation of qi promoting, antiinflammatory, rheumatism.The Fang Zhongjia vitamin B
6Be in order to prevent that indometacin from causing gastrointestinal reaction.
Embodiment 2 (No. 2, quickly-acting analgesic)
Dosage form and composition: tablet, every contains rotundine 60mg, Anisodamine 5mg.
Cure mainly: the pain that the visceral smooth muscle spasm causes (as biliary tract, chronic gastritis, chronic enteritis, peptic ulcer, ulcerative colitis, dysmenorrhea, pain of childbirth etc.).
Usage and consumption: oral, each 1--2 sheet, every day 3--4 time.
The side separates: above prescription mesocrany is logical surely at nervus centralis performance analgesic activity, and the circulation of qi promoting of energy blood circulation promoting and blood stasis dispelling; Anisodamine can be removed smooth muscle spasm, at periphery performance analgesic activity.These two kinds of medicines are compatible, can be at two links performances of maincenter and periphery analgesic activities, and its comprehensive analgesic activity is better than single with rotundine with singly use Anisodamine.
Above-mentioned two embodiment, through on probation, its analgesic effect is good, and no significant side effects is subjected to the welcome of extensive patients.
Claims (3)
1, a class quickly-acting antalgic is characterized in that rotundine class and antipyretic analgesic compatiblely, or rotundine class and m receptor blocker is compatible, makes compound preparation.
2, quickly-acting antalgic as claimed in claim 1 is characterized in that: with rotundine and the compatible compound preparation of making of indometacin.
3, quickly-acting antalgic as claimed in claim 1 is characterized in that: with rotundine and the compatible compound preparation of making of Anisodamine.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 98116986 CN1243704A (en) | 1998-07-31 | 1998-07-31 | Quickly-acting analgesic |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 98116986 CN1243704A (en) | 1998-07-31 | 1998-07-31 | Quickly-acting analgesic |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1243704A true CN1243704A (en) | 2000-02-09 |
Family
ID=5225304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 98116986 Pending CN1243704A (en) | 1998-07-31 | 1998-07-31 | Quickly-acting analgesic |
Country Status (1)
Country | Link |
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CN (1) | CN1243704A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1310646C (en) * | 2002-09-18 | 2007-04-18 | 中国人民解放军军事医学科学院毒物药物研究所 | Medicinal composition containing rotundine for anayesia and giving up drug-taking |
-
1998
- 1998-07-31 CN CN 98116986 patent/CN1243704A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1310646C (en) * | 2002-09-18 | 2007-04-18 | 中国人民解放军军事医学科学院毒物药物研究所 | Medicinal composition containing rotundine for anayesia and giving up drug-taking |
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Addressee: Sun Jizu Document name: Notice of publication of application for patent for invention |
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