CN1243451A - An apparatus for the ultrasonic separation and cleaning of a suspension - Google Patents
An apparatus for the ultrasonic separation and cleaning of a suspension Download PDFInfo
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- CN1243451A CN1243451A CN98801646A CN98801646A CN1243451A CN 1243451 A CN1243451 A CN 1243451A CN 98801646 A CN98801646 A CN 98801646A CN 98801646 A CN98801646 A CN 98801646A CN 1243451 A CN1243451 A CN 1243451A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
- B08B3/12—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration by sonic or ultrasonic vibrations
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Abstract
The present invention relates to an apparatus for the separation of the suspending particles of a liquid such as blood by an ultrasound treatment. The apparatus comprises a first container enclosing an ultrasonic generator, an ultrasonic driver and a second container filled with a liquid containing the suspending particles. The second container is sited between the reflecting wall and the ultrasonic generator in the first container. The space between the first and the second container is filled with a liquid for delivering ultrasonic waves. There is at least one aperture at the bottom of the second container. There are compartments partitioned by some baffles along the circuit of the second container. The compartments are in communication with each other at the top and the bottom of the second container.
Description
Technical field
The present invention relates to the device of a kind of ultrasonic Separation suspended particle in liquid, especially particulate such as haemocyte; The invention still further relates to the piece-rate system of can continuous clinically or quasi-continuous separation and cleaning haemocyte.
Background technology
Suspended particulate has many methods in the separating liquid, more commonly adopts centrifugal separation.But when separate small particles,, adopt centrifugal separating device particularly in the occasion that needs washed corpuscles and blood plasma, not only very complicated, and cost an arm and a leg, cause infringement simultaneously easily to haemocyte.
The instrument that Chinese patent application discloses a kind of separating blood No. 911058486, this instrument comprises a transducer driving circuit, a transducer (supersonic generator) and reflection containers and blood container, wherein transducer is the circular arc or the tubular transducer that can produce cylindrical wave, reflection containers and blood container and transducer have same shape, and the three places coaxially.
The instrument that also discloses a kind of separating blood Chinese patent application 94104548.X number, this instrument comprises a transducer driving circuit, a transducer (supersonic generator) and reflection containers and blood container, wherein transducer, reflecting wall and container can be cylindrical separately, the shape of truncated cone-shaped or reverse frustoconic, the three can constitute different combinations, central shaft and horizontal vertical, and overlap.
One of important application of these instruments is a separating blood.Yet, in above-mentioned document, all do not mention the cleaning problem of blood in this instrument ultrasonic Separation process, more do not mention blood cleans in the ultrasonic Separation uniformity and cleaning efficiency problem.
The device that the purpose of this invention is to provide a kind of suspension ultrasonic Separation and cleaning.
Another purpose of the present invention provides the device of suspended particulate in a kind of separating liquid with high cleaning uniformity and cleaning efficiency.
Another purpose of the present invention provides a kind of device with high score suspended particulate in the separating liquid of speed.
Another purpose of the present invention provides a kind of system of the separating blood that can use clinically.
Other purpose of the present invention can obtain embodying in further elaboration of the present invention.
Summary of the invention
The present invention is about a kind of ultrasonic Separation suspended particulate, the blood cell in molecule such as the blood especially, and the device that suspended particulate is cleaned.This device comprises first container of being with reflecting wall, is arranged in the ultrasonic generator of this first container, is used to second container that drives the ultrasonic drivers of this ultrasonic generator and be used for the fluid of splendid attire band suspended particulate; This second container is arranged in this first container, and between this reflecting wall and this ultrasonic generator, is used for the matching fluid that splendid attire is beneficial to ultrasonic transmission between this second container and this first container, is formed with an opening that can be used for injecting fluid at second container bottom; Wherein second container is along circumferentially being divided into some compartments by some dividing plates, and these compartments are communicated with in the top and the bottom flow of second container respectively.
According to the present invention, can further improve cleaning efficiency by changing number of openings, shape and the position of injecting fluid.
The invention still further relates to the blood separation system that to use clinically.
The accompanying drawing summary
Fig. 1 is the profile of a kind of embodiment of apparatus of the present invention.
Fig. 2 A-2B is the schematic diagram of two kinds of embodiments of apparatus of the present invention.
Fig. 3 A-3E is the schematic diagram of the second container vertical section in some embodiments of apparatus of the present invention.
Fig. 4 is the schematic diagram of another embodiment of apparatus of the present invention.
Fig. 5 A-5C is the schematic diagram of the dividing plate of a kind of embodiment of apparatus of the present invention.
Fig. 6 A-6C is the schematic diagram of the unhurried current ring of a kind of embodiment of apparatus of the present invention.
Fig. 7 is the profile of a kind of embodiment of apparatus of the present invention.
Fig. 8 is the work schematic diagram of blood separation system of the present invention.
Fig. 9 is a kind of embodiment that the present invention adds cleaning fluid.
Detailed Description Of The Invention
The inventor is through long term studies, discovery with ultrasonic method from fluid such as liquid in blood cell in separation of suspended, especially molecule such as the blood etc., separation container is divided into some relatively independent compartments, and these compartments are communicated respectively in the top and the bottom of second container, can in same container, can finish separation of suspended particle and can finish its cleaning again, and have high cleaning uniformity and cleaning efficiency, thereby improved separating rate and efficient on the whole.This high cleaning uniformity and the raising of cleaning efficiency and overall separation speed and efficient, supposition is because these compartments communicate in the top and the bottom of second container respectively, when from container bottom adding cleaning fluid, utilize the liquid self characteristics, add uniform purpose and reach cleaning fluid, thereby make it have high cleaning uniformity; And because cleaning fluid such as water are to flow along the direction vertical with liquid level basically in each compartment, thereby make it have high cleaning efficiency; And overall separation speed and efficient have been improved thus.
Fig. 1 represents a kind of suspended particulate of the present invention especially ultrasonic Separation and the cleaning device of blood cell in molecule such as the blood, comprise first container 10 of being with reflecting wall, be arranged in the ultrasonic generator 20 of this first container, the second airtight container 30 that is used to the fluid that drives the ultrasonic drivers (not shown) of this ultrasonic generator and be used for splendid attire band suspended particulate; This second container is arranged in this first container, and between this reflecting wall and this ultrasonic generator, be loaded with the matching fluid that is beneficial to ultrasonic transmission between this second container and this first container, at least one aperture 11 is arranged in the bottom of second container, be used for adding and discharging suspension such as blood and cleaning fluid such as water; Wherein second container circumferentially is divided into some compartments by some dividing plates 50 along it, each compartment at the top 3 and bottom 4 fluids be communicated with.
Fig. 2 A is the structural representation of apparatus of the present invention.Second container 30 is divided into five compartments of C1-C5, and these compartments communicate with each other in the top 3 and the bottom 4 of second container respectively.In addition, second container 30 is divided into two zones, promptly superposed waste liquid retention areas 1 and the effective separated region 2 that is positioned at the bottom, and effectively the height of separated region 2 is corresponding to hyperacoustic useful effect height of ultrasonic generator generation.When from the aperture 11 when adding suspension such as blood or cleaning fluid such as water, the air in second container is discharged from opening 12, because fluid connection effect, the liquid level of suspension in each compartment such as blood or cleaning fluid such as water will be maintained at the same horizontal plane.That is to say that 11 when adding cleaning fluids such as water from the aperture, reach before top 3 communicates that cleaning fluid will evenly pass through each compartment at cleaning fluid.Separate and the process of cleaning is such with this separator: at first 11 add a certain amount of suspension from the aperture, the addition of suspension should guarantee that its interface is positioned at effective separated region so that ultrasonic Separation can be carried out effectively, after ultrasonic Separation, suspended particulate is deposited in the bottom of second container as blood cell; Add cleaning fluid such as water then, as long as its liquid level does not reach the top 3 of second container and communicates; Distinguish suspended particulate such as blood cell and clean waste liquid by effective detection method such as optical detecting method at last, sequentially extract suspended particulate such as blood cell and waste liquid out, reach through separating and separate with waste liquid with the suspended particulate that cleans from the aperture 11 of bottom.
Fig. 2 B is the schematic diagram of another embodiment of apparatus of the present invention.Second container 30 of the present invention is divided into five compartments of C1-C5.These compartments communicate with each other in the top 3 and the bottom 4 of second container.Opening 12 is arranged at the top 3 at second container, is used for discharging in second container gas or inflates to second container.On the wall above the effective separated region of being positioned at of each compartment, have one to clean discard solution discharge port 5.After ultrasonic Separation, suspended particulate such as blood cell are deposited in the bottom of second container; At this moment, 11 add cleaning fluid such as water from the aperture, will cover relatively independent compartment and will enter top 3 and when communicating when cleaning waste liquid, close aperture 11, from opening 12 pressurizations, at this moment, be discharged from second container via the cleaning discard solution discharge port, thereby separate with suspended particulate through ultrasonic Separation and cleaning at the waste liquid that cleans discard solution discharge port 5 above positions.Preferably, clean discard solution discharge port 5 and be positioned at effective separated region top, more preferably, clean discard solution discharge port near effective separated region setting.This cleaning discard solution discharge port 5 should guarantee that the liquid that can not that is positioned at its top flows out because of the pressure of himself, can install valve such as each outlet.Described cleaning discard solution discharge port is in same horizontal plane substantially.
According to the present invention, the mode that adds fluid such as suspension and cleaning fluid by aperture 11 can be diversified.Described aperture 11 preferably makes cleaning fluid circumferentially in the same way the flowing along second container to small part, and can within each barrier, produce certain vortex, thereby suspension such as blood are contacted fully with cleaning fluid such as water, make the cleaning of blood more thorough, more effective.Carry out in such aperture mode as shown in Figure 9, perhaps extends to the conduit adding of bottom by one or more portions from container.In the case, the end of conduit more preferably becomes 0 degree angle from the horizontal by positive and negative 20 degree with level.
The quantity in aperture 11 can be more than or equal to 1, and this is relevant with size of second container etc., is preferably 2-6, more preferably 3.For the situation in a plurality of apertures, preferably it circumferentially evenly distributes along second container, as axial symmetry.For example, when being 3 for the quantity in aperture 11, it circumferentially distributes in space 120 degree modes along second container.Position each other, aperture preferably is on the same horizontal plane substantially, and cleaning fluid can be flowed more equably, thereby improves the quality that blood cleans.
If the density of suspended particulate is less than the density of solvent, suspended particulate will speed up under ultrasonication upwards to be assembled.In this case, above-mentioned structure is done suitable variation can reach still that into washing lotion is even, fast the purpose of separating.Referring to Fig. 4, container 71 and 72 is formed by some relatively independent compartments, these compartments communicate at the top, and wherein each compartment D1-D5 of container 71 links to each other correspondingly with each compartment E1-E5 of container 72, and the integral position of container 72 is wanted the horizontal level height of container 71.Its working procedure is: at first add suspension through the aperture 11 of container 71, keep the air at container 71 tops 4 few as much as possible, and carry out ultrasonic Separation; After ultrasonic Separation, again through the aperture 11 the filling cleaning fluids.Because each compartment is relatively independent, cleaning fluid evenly enters each compartment under the gravity effect.Carried out one-period or waste liquid will cover container 72 and enter its top 3 that is connected the time when cleaning, can in container 71, inflate through aperture 11, thereby waste liquid is ejected opening 12, and then 11 gas extracted out, and continued to add washing lotion through the aperture.The concentrate of suspended particulate is 11 extractions through the aperture, promptly finish a cleaning process.
In the above-mentioned structure, the opening of the container 72 that links to each other with container 71 also can be respectively arranged with two way valve, like this when waste liquid will cover container 72 and enter its top 3 that is connected, closing containers 71 and container 72 be passage one to one, from 12 pressurizations of container 72 openings, with another passage amount discharge container 72 of the waste liquid in container 72 each compartment through valve.Container 71 and container 72 also can constitute an integral body in addition.
According to the present invention, said dividing plate can be a flat board, this dividing plate can with the substantially parallel placement of vertical axis of ultrasonic generator, or with the placement that has a certain degree of this axis, preferably with the substantially parallel placement of vertical axis of ultrasonic generator; More preferably dividing plate is along the radially setting of ultrasonic generator.
According to one preferred embodiment of the present invention, the vertical axis line parallel of said dividing plate top and ultrasonic generator, the inclined-plane that bottom and axis have a certain degree.Otherwise, also can be divided into the inclined-plane in said dividing plate top, the vertical axis line parallel of lower part and ultrasonic generator.Said dividing plate chamfered portion can be a plane, also can be a curved surface, is preferably level and smooth curved surface.Said chamfered portion will help the rapid subsidence of suspended particulate in the ultrasonic Separation process.The divider upright part can change according to actual needs with the ratio of the height of chamfered portion.Preferably said dividing plate to the horizontal transversal of small part points to the vertical axis of ultrasonic generator, and more preferably said curved surface horizontal transversal everywhere points to said axis, and most preferably said dividing plate horizontal transversal everywhere points to said axis.
According to the present invention, the dividing plate that is used for second container is separated into some compartments can circumferentially evenly or anisotropically distribute along second container; Preferably distribute equably, when adding blood or cleaning fluid such as water like this, before the top that arrives second container, cleaning fluid flows into and the steric hindrance that flows through each compartment reaches unanimity more, add cleaning fluid such as water more equably thereby reach, make that the blood in each compartment obtains more uniform cleaning.The quantity of dividing plate can change in the larger context according to the size of second container, and for separating blood, its quantity is generally 4-60, preferred 10-50, and more preferably 20-40 most preferably is 30.
In device of the present invention, said dividing plate can be the dividing plate of same kind of configuration, it also can be the dividing plate of configuration of the same race not, preferred said dividing plate is with a kind of configuration, like this when adding blood or cleaning fluid such as water to second container, before the top that arrives second container, cleaning fluid flows into and the steric hindrance that flows through each compartment reaches unanimity more, add cleaning fluid such as water more equably thereby reach, make that the blood in each compartment obtains more uniform cleaning.
According to the present invention, the size of dividing plate should be with second container coupling so that compartment is relative separates, and compartment is communicated respectively in the top and the bottom of second container.Can be connected with any method that is known in the art between dividing plate and second wall of a container, as utilize inside and outside two walls of second container strain pressure and fixing or adopt adhesive or directly and the inwall of second container or outer wall or both constitute one.
According to the present invention, the shape of first container and ultrasonic generator can be various.For example the wall of first container and/or ultrasonic generator can be designed to vertical or tilt, as cylindrical, truncated cone-shaped or reverse frustoconic.The shape of first container of the present invention and ultrasonic generator with and with second container mutual alignment relation can be as being disclosed in the Chinese patent application No. 911058486 and No. 94104548 those.For ultrasonic generator is separated effectively, the cylinder ultrasonic wave that ultrasonic generator is sent acts on effective separated region basically.Preferred first container, second container and ultrasonic generator vertical axis are provided with coaxially.
According to the present invention, the shape of second container can be various, as be disclosed in the Chinese patent application No. 911058486 and No. 94104548 those.Wall can be designed to vertical or tilt, and constitutes wedge shape as cylindrical, truncated cone-shaped or reverse frustoconic or its inwall, and perhaps the wall of part cavity is cylindrical, and the wall of part cavity is a truncated cone-shaped.The wall of second container and vertical direction have a certain degree and just can reach the purpose that helps rapid subsidence.This second container is preferably annular cavity; More preferably the cross-sectional area of the waste liquid stagnant area of said annular cavity is greater than the cross-sectional area of effective Disengagement zone, like this for a certain amount of suspension, there is bigger space to hold the cleaning waste liquid, and can dwindle the apparent size of this ultrasonic separation means greatly, save the space, see Fig. 3 A-E.Fig. 3 A is the preferred configuration of the present invention's second container, and the outer wall of said hollow circular ring shape cavity is the annulus of single diameter; The longitudinal section of the inwall of said annular cavity is a stairstepping, its upper and lower two parts also are respectively the annulus of single diameter, the lower end of said upper inside wall is higher than the upper end of said inwall bottom, thereby make the step part that forms a taper type between upper and lower two parts of said inwall, its bus and level are angled; The top of the outer wall of said annular cavity is lower than the top of its inwall, and therefore, the loam cake of second container is a taper type also, and the lower cover of second toroidal container is an annular flat board.Fig. 3 B is depicted as the another kind of preferred form of second toroidal container, and wherein, its outer wall is a stairstepping, and inwall is an annular, and upper and lower covers is respectively the annular flat board.
The volume that the size in the volume of second container and inside and outside footpath and the volume and being used to that is used to hold the bottom of suspension such as blood hold the top of cleaning waste liquid can change according to actual needs, as long as its underpart is even as big as holding a certain amount of suspension and as long as top is even as big as holding the waste liquid amount with suspension such as clear Xian of blood generation to a certain degree the time.For the situation of separating blood, the blood flow volume of adding is generally 100-2000ml, is preferably 300-1500ml, more preferably 500-1000m1; Its internal diameter is generally 3-20cm, is preferably 5-18cm, more preferably 8-17cm.For industrial as processing waste water, the amount of each suspension of handling can change according to actual needs.
In addition, second container also can adopt the top cross-sectional area less than the long-pending inverted structure of lower cross section, and this structure is particularly useful for the situation of suspended particulate density less than solvent density.According to the present invention, the ultrasonic Separation of suspension and cleaning process can be cleaned then for advanced person's row ultrasonic Separation, or carry out ultrasonic Separation and cleaning simultaneously, or be carried out ultrasonic Separation earlier and clean under ultrasonication then.Preferably carry out ultrasonic Separation earlier and clean then, or carry out ultrasonic Separation earlier and under ultrasonication, clean then.
Reflecting wall of the present invention can be used as the wall or the part wall of first container.In order to increase reflecting wall, should select to do reflecting wall with the big material of the acoustic resistance difference of processed fluid or matching fluid to hyperacoustic reflecting effect.Conventional reflection wall materials has, for example stainless steel, copper, iron and aluminium or the like, and also available polyethylene or pvc material are especially when reflecting wall during also as the wall of second container.
The selection of the wall thickness of this second container should help ultrasonic transmission.Generally be to get over Bao Yuehao, or get used ultrasonic wave half-wave wavelength and make thickness.The material of second container should be selected and the consistent as far as possible material of the acoustic resistance of object being treated, as polyethylene or polypropylene.
According to the present invention, the mutual alignment of this reflecting wall and this ultrasonic generator and/or structure are designed to make has angle β between this ultrasonic generator ultrasonic incidence wave that produces and the reflected ultrasonic wave that reflects from this reflecting wall.The scope of this angle β is 5-90 °, preferred 10-80 °.
The vibration mode of ultrasonic generator can have multiple, as radial vibration, thickness vibration.Generally, when the granularity of suspended particulate is big, adopt the lower radial vibration mode of supersonic frequency; When granularity hour, adopt thickness vibration mode.For example when processing blood, preferably adopt thickness vibration mode.On ultrasonic generator, can also add protective layer or matching layer,, can add also that on reflecting wall anticorrosive coat such as polytetrafluoroethylene (PTFE) etc. are with the protection reflecting wall to prevent corrosion.
According to the present invention, suspension or clear Xian's liquid such as water can add equably from container bottom; Also can be via the conduit that communicates with container bottom portion's adding from container.
Dividing plate of the present invention can be selected different materials according to actual needs for use, and for the situation of separating blood, it should be any material with blood compatibility, as polyethylene or polypropylene etc.
According to the present invention, can be provided with the buffer unit that is used to cushion the liquid stream that enters each compartment in the lower end of part or all of compartment.Said buffer unit also can constitute an integral body (preferred embodiment of the invention).
Fig. 7 has provided a kind of ultrasonic separation means of isolating haemocyte from blood, is the preferred embodiments of the invention.It comprises truncated cone-shaped ultrasonic generator 20, be similar to second container 30 of the hollow of structure shown in Fig. 3 A, first container 10 of columniform band reflecting wall, wherein along circumferentially being divided into some compartments, these compartments communicate in the top 3 and the bottom 4 of second container 30 second container 30 by dividing plate 50 (its structure ubi infra).Second container 30 is divided into the bigger waste liquid stagnant area of superposed cross-sectional area and is positioned at the less effective Disengagement zone of cross-sectional area of bottom, on the inwall above the effective Disengagement zone of being positioned at of each compartment, be formed with one and clean discard solution discharge port 5, floss hole 5 preferably is provided with near effective Disengagement zone, and each floss hole 5 liquid outlet links to each other with the waste fluid container (not shown) by means of the fluid passage.The top of second container 30 is formed with opening 12, is used for getting rid of the air of second container and adds gas in second container making the cleaning waste liquid that is positioned at cleaning discard solution discharge port 5 tops discharge second container.Second container bottom also is provided with a unhurried current ring 70, and its structure as shown in Figure 6.Unhurried current ring 70 is a cirque structure, and its cross section is the channel-section steel type, and its openend is abutted against the annular lower cover in second container, thereby forms an annular compartment 100 that seals with the annular lower cover.The top end face of unhurried current ring 70 is abutted against in the lower end of each dividing plate 50, the position corresponding to each compartment at unhurried current ring top end face is formed with the aperture 75 littler than each compartment cross section, thereby make each compartment via each aperture 75 fluid communication with each other, the certain altitude of each 75 top, aperture has a deflection plate, be fixed on the top in aperture with column, enter the liquid stream of each compartment in order to buffering.In addition, on the end face of unhurried current ring top, also be formed with an aperture 76, be used for equipped woven hose blood or cleaning fluid injection sealing annular compartment 100.
Used dividing plate is made up of upper and lower two parts 7,9 and mid portion 8 as shown in Figure 5.Top 7 is a flat board, and its shape is corresponding with the cross section of the waste liquid stagnant area of second container 30, but its top is cut, so that each compartment in second container communicates with each other at second container top.Lower part 8 also is a flat board, and mid portion 9 is a level and smooth curved slab.Curved slab 8 forms by a line segment is rotated around the axle center to move along axis simultaneously, thereby curved slab 8 horizontal transversal everywhere all points to the ultrasonic generator axis.Preferably, dull and stereotyped 7,9 everywhere horizontal transversals also point to the ultrasonic generator axis, thereby stop the ultrasonic wave that supersonic generator sends and the ultrasonic wave of the first container reflecting wall reflected back as few as possible, thereby improve the ultrasonic Separation effect.The angle of the projection line of two plate parts 7,9 (Fig. 5 B) is generally 0-70 ° in the vertical view, is preferably 10-60 °, more preferably 20-50 °, most preferably is 30-40 °.
The material selection of second container 30 and the consistent as far as possible material of the acoustic resistance of blood are as polyethylene, polypropylene or polyvinyl chloride etc.The sodium chloride that is used for splendid attire matching fluid such as water or 1% between second container 30 and the ultrasonic generator 20.Also be used for the splendid attire matching fluid between second container 30 and first container.Ultrasonic generator 20, second container 30 and the 10 coaxial settings of first container.
Radial distance between the reflecting wall of the ultrasonic generator 20 and first container can be selected according to the type and the requirement of processed material.Preferred radial distance is the integral multiple of used ultrasonic wave half-wavelength, can constitute a resonant cavity like this.
The ultrasonic power density that ultrasonic generator is launched is up-small and down-big, so just can make the blood cell crypto set more of bottom, separates more thoroughly, and the blood cell on top is unlikely to be subjected to too much radiation in whole separation process.
Fig. 8 is separation of the present invention and the flow chart that cleans hematological system.Whole process may further comprise the steps:
(1) advances blood, closed control valve F4, peristaltic pump 100 rotations will be contained the middle air of blood container 102 (second containers of apparatus of the present invention) and be entered among the waste fluid bag D5, make the blood that mixes with anti-coagulants D1 suck and contain blood container 102, arrive to liquid level till the upper limit of separating the effective coverage through hemofilter L1;
(2) separate, start the ultrasonic transducer work of containing shaft position in the blood container 102, the blood in the container 102 is separated, its top is blood plasma, the red blood cell of bottom for concentrating;
(3) clean, method in 1 set by step, cleaning fluid in the cleaning fluid D2 suck is contained blood container 102, make it in uphill process, fully clean red blood cell of having concentrated (can carry out simultaneously in this process ultrasonic, also can liquid to be cleaned be full of container then carry out ultrasonic Separation again);
(4) discharge opeing, control valve F1, F2 and F3 close, and F4 opens, and peristaltic pump reverses simultaneously, gas is pumped into from waste fluid bag D5 contain blood container 102, and the waste liquid of being made up of cleaning fluid, blood plasma etc. on container 102 tops 105 is entered among the waste fluid bag D5 by the road;
(5) collect blood, control valve F3 unlatching, F4 closes, and peristaltic pump 100 continues to reverse, and uses preparing against among the red blood cell input blood bag D3 that cleans.
According to actual needs, in each processing procedure (step 1-5), step 3,4 can repeatedly circulate; Blood volume increases, and number of processes also can correspondingly increase, till whole pending blood processing are intact.
According to this ultrasonic Separation hematological system of the present invention, can be used for not only that general blood separates but also because good separating effect, separating rate height, feed liquor good uniformity, can also be in the clinical blood separation of carrying out, to satisfy some clinical specific demands.
Since device solves of the present invention in the ultrasonic Separation blood cleaning process of blood and cleaning fluid such as water add fashionable uniformity, thereby guaranteed the uniformity that blood cleans; And because cleaning fluid such as water in cleaning process, are to flow from descending along the direction vertical with liquid level basically, guaranteed the abundant cleaning of blood, improved the efficient of cleaning, thereby improved separating rate on the whole; And cleaning fluid such as water enters each corner in the separation container equably in cleaning process, fully mixes with blood, thereby improved clean result greatly.
Those skilled in the art can design other structure or provide different schemes by design of the present invention, and these structures or scheme are considered to belong to scope of the present invention, are included in the following claim.
Claims (16)
1, a kind of device that utilizes the ultrasonic Separation suspended particulate, comprise first container of being with reflecting wall, be arranged in the ultrasonic generator of this first container, be used to drive the ultrasonic drivers of this ultrasonic generator, with second container that is used for splendid attire band suspended particulate fluid, this second container is arranged in this first container, and between this reflecting wall and this ultrasonic generator, be used for the matching fluid that splendid attire is beneficial to ultrasonic transmission between this second container and this first container, be formed with at least one aperture in the bottom of second container, wherein second container circumferentially is divided into some compartments by some dividing plates along it, and these compartments are communicated with in the top and the bottom flow of second container respectively.
2,, it is characterized in that being provided with an opening at the top of said second container according to the device of claim 1.
According to the device of claim 1, it is characterized in that 3, described aperture makes the cleaning fluid of adding at least in part along the circumferential co-flow of second container.
According to the device of claim 3, it is characterized in that 4, described aperture is 2-6, be preferably 3, and described aperture distributes evenly along second container perimeter.
5, according to the device of claim 2, it is characterized in that, on the wall of described each compartment, be formed with one and clean discard solution discharge port, be used for the cleaning waste liquid of its top is discharged second container, described cleaning discard solution discharge port is located substantially on the same horizontal plane, and described open top is used for to second container filling air pressure.
6, as each device among the claim 1-5, it is characterized in that forming a chamber between second container bottom and each the compartment bottom, each compartment is via this chamber fluid communication with each other, and the fluid of filling evenly enters each compartment after being full of this chamber; Form a chamber between second container top and each the compartment upper end, each compartment is via this chamber fluid communication with each other.
7,, it is characterized in that said first container, second container and ultrasonic generator are provided with coaxially with respect to the vertical axis of ultrasonic generator according to the device of claim 6.
8,, it is characterized in that said each dividing plate circumferentially distributes equably along second container according to the device of claim 7.
9, device according to Claim 8 is characterized in that said each dividing plate all points to the vertical axis of ultrasonic generator at the transversal of vertical position along continuous straight runs.
10, according to the device of claim 9, the upper and lower that it is characterized in that said dividing plate is for dull and stereotyped, and the mid portion of said dividing plate is a level and smooth curved slab.
11, according to each device in the claim 3 to 9, it is characterized in that said second container is the annular cavity of hollow, and the cross-sectional area that said hollow circular ring shape cavity is positioned at the part of cleaning the discard solution discharge port top is positioned at the cross-sectional area of the part of cleaning the discard solution discharge port below greater than it.
12, according to the device of claim 11, the outer wall that it is characterized in that said second container is the cylinder of single diameter, the inwall of said second container is a stairstepping along the longitudinal section of ultrasonic generator vertical axis, said upper inside wall and bottom also respectively are the cylinder of single diameter, the lower end of said upper inside wall is not less than the upper end of said inwall bottom, and what connect said upper inside wall and bottom is the step part of taper type.
13, according to the device of claim 12, the cross-sectional area of following end entrance that it is characterized in that the part compartment is provided with a deflection plate less than this compartment cross-sectional area herein above inlet, is used to cushion the liquid stream that enters each compartment.
14, according to the device of claim 13, the cross-sectional area of following end entrance that it is characterized in that whole compartments is provided with a deflection plate less than this compartment cross-sectional area herein above inlet, is used to cushion the liquid stream that enters each compartment.
15, a kind of device that utilizes the ultrasonic Separation suspended particulate, comprise first container of being with reflecting wall, be arranged in the ultrasonic generator of this first container, be used to drive the ultrasonic drivers of this ultrasonic generator, with second container that is used for splendid attire band suspended particulate fluid, this second container is arranged in this first container, and between this reflecting wall and this ultrasonic generator, be used for the matching fluid that splendid attire is beneficial to ultrasonic transmission between this second container and this first container, wherein second container circumferentially is divided into some compartments by some dividing plates along it, these compartments are communicated with at the top of second container fluid, at second container top one opening are arranged; One the 3rd container is arranged above second container, and the 3rd container is vertically divided into some compartments, and these compartments and each compartment of second container fluid one by one are communicated with, and logical at the top of the 3rd container fluid, is provided with an opening at the top of the 3rd container.
16, a kind of blood separation system comprises the device of claim 1-15.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97101043.9 | 1997-01-24 | ||
| CN97101043A CN1188682A (en) | 1997-01-24 | 1997-01-24 | Ultrasonic separating and washing unit for suspension |
| PCT/CN1998/000015 WO1998032516A1 (en) | 1997-01-24 | 1998-01-24 | An apparatus for the ultrasonic separation and cleaning of a suspension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1243451A true CN1243451A (en) | 2000-02-02 |
Family
ID=5165479
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97101043A Pending CN1188682A (en) | 1997-01-24 | 1997-01-24 | Ultrasonic separating and washing unit for suspension |
| CN98801646A Pending CN1243451A (en) | 1997-01-24 | 1998-01-24 | An apparatus for the ultrasonic separation and cleaning of a suspension |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97101043A Pending CN1188682A (en) | 1997-01-24 | 1997-01-24 | Ultrasonic separating and washing unit for suspension |
Country Status (3)
| Country | Link |
|---|---|
| CN (2) | CN1188682A (en) |
| AU (1) | AU5746998A (en) |
| WO (1) | WO1998032516A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3386652B1 (en) * | 2015-10-14 | 2022-06-22 | Sonosep Technologies Inc. | Methods, systems, and apparatuses for acoustically separating and washing particles |
| CN108101151A (en) * | 2017-12-24 | 2018-06-01 | 江苏梅兰化工有限公司 | A kind of supersonic wave suspended liquid/gas separator |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4763677A (en) * | 1986-11-26 | 1988-08-16 | Techalloy Illinois, Inc. | Sonic treatment apparatus |
| WO1994008732A1 (en) * | 1992-10-08 | 1994-04-28 | Sofima Ag | Process and device for acoustically irradiating and transferring vibrations to an acoustic irradiation fluid containing particles |
| US5383483A (en) * | 1992-10-14 | 1995-01-24 | Shibano; Yoshihide | Ultrasonic cleaning and deburring apparatus |
| CN1091626C (en) * | 1994-04-28 | 2002-10-02 | 王晓庆 | Instrument for separating suspended particles by utilizing supersonic wave |
-
1997
- 1997-01-24 CN CN97101043A patent/CN1188682A/en active Pending
-
1998
- 1998-01-24 WO PCT/CN1998/000015 patent/WO1998032516A1/en active Application Filing
- 1998-01-24 CN CN98801646A patent/CN1243451A/en active Pending
- 1998-01-24 AU AU57469/98A patent/AU5746998A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1188682A (en) | 1998-07-29 |
| WO1998032516A1 (en) | 1998-07-30 |
| AU5746998A (en) | 1998-08-18 |
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