CN1242820C - Nano magnetic-heating seed for thermal therapy and preparation method and application thereof - Google Patents
Nano magnetic-heating seed for thermal therapy and preparation method and application thereof Download PDFInfo
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- CN1242820C CN1242820C CN 01134012 CN01134012A CN1242820C CN 1242820 C CN1242820 C CN 1242820C CN 01134012 CN01134012 CN 01134012 CN 01134012 A CN01134012 A CN 01134012A CN 1242820 C CN1242820 C CN 1242820C
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- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 238000010438 heat treatment Methods 0.000 title claims description 62
- 238000002560 therapeutic procedure Methods 0.000 title abstract description 9
- 239000006247 magnetic powder Substances 0.000 claims abstract description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000004094 surface-active agent Substances 0.000 claims abstract description 28
- 238000002347 injection Methods 0.000 claims abstract description 14
- 239000007924 injection Substances 0.000 claims abstract description 14
- 238000005406 washing Methods 0.000 claims abstract description 5
- 239000007787 solid Substances 0.000 claims abstract description 4
- 239000000725 suspension Substances 0.000 claims abstract description 4
- 238000001035 drying Methods 0.000 claims abstract description 3
- 238000000015 thermotherapy Methods 0.000 claims description 44
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 238000002604 ultrasonography Methods 0.000 claims description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 239000006228 supernatant Substances 0.000 claims description 4
- 230000005308 ferrimagnetism Effects 0.000 claims description 3
- 230000005307 ferromagnetism Effects 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 claims description 3
- 235000019982 sodium hexametaphosphate Nutrition 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 3
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 2
- 238000004062 sedimentation Methods 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 abstract description 31
- 238000002156 mixing Methods 0.000 abstract description 2
- 239000000084 colloidal system Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 description 11
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000002245 particle Substances 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 210000000683 abdominal cavity Anatomy 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 210000001165 lymph node Anatomy 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 2
- ZFZWKDFIUQMZHV-UHFFFAOYSA-M [Br-].[NH4+].C(CCCCCCCCCCCCCCC)[N+](CC1=CC=CC=C1)(C)C.[Br-] Chemical compound [Br-].[NH4+].C(CCCCCCCCCCCCCCC)[N+](CC1=CC=CC=C1)(C)C.[Br-] ZFZWKDFIUQMZHV-UHFFFAOYSA-M 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 239000000696 magnetic material Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 201000005249 lung adenocarcinoma Diseases 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000011858 nanopowder Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000000771 oncological effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a nano magnetic-thermal seed for thermal therapy, a preparation method and application thereof, and relates to a magnetic-thermal seed which is prepared by adopting nano magnetic powder as a main component and is used for thermal therapy of tumors, and a preparation method and application thereof. The nano magnetic-thermal seed for thermal therapy is characterized by comprising nano magnetic powder and a surfactant in a certain weight ratio of 1: 0-0.05. The preparation method comprises the steps of mixing nano magnetic powder and a surfactant into pure water according to a certain ratio, wherein the weight ratio of the nano magnetic powder to the surfactant to the pure water is 1: 0-0.05: 0.5-20; removing the redundant surfactant by fully dispersing the surfactant into colloid or suspension and washing the colloid or suspension by pure water; adding water solution, and dispersing to obtain nanometer magnetic seed water solution for injection or drying to obtain nanometer magnetic seed for solid thermal therapy. The invention relates to a nano magnetic seed for thermal therapy, which is used as a magnetic seed and applied to the thermal therapy of the magnetic seed for treating various tumors.
Description
Technical field
Nano magnetic heating seed for thermotherapy of the present invention and its production and use relates to is that a kind of nano-magnetic powder that adopts is magnetic heating seed that is used for the thermotherapy treatment tumor of making of Main Ingredients and Appearance and its production and use.
Background technology
The magnetic heating seed thermotherapy is that a kind of utilization is in the magnetic hysteresis that the magnetic heating seed at in-vivo tumour position produces and gives birth to heat effect heating tumor, the thermotherapy method of selectively killing tumor cell, treatment tumor.Compare with other external thermotherapy methods, it has the temperature precise control, tumor normal surrounding tissue and outstanding advantage such as safe and reliable accurately, are not damaged in the location, has become a kind of effective ways for the treatment of tumor.But the used magnetic heating seed of magnetic heating seed thermotherapy all is the above magnetic material of micron order at present, because the magnetic material particle diameter is bigger, reunite easily, be unsuitable for injections such as blood vessel, muscle, can not do oral, only be suitable for pre-buried and two kinds of occupation modes of injection tumor locus, there are limitation in range of application and therapeutic effect.
Summary of the invention
The present invention is directed to above-mentioned weak point a kind of nano magnetic heating seed for thermotherapy and its production and use is provided, prepare magnetic heating seed by the nano powder that adopts various sizes, make magnetic heating seed can penetrate various in-vivo tissues, arrive any position in the body, the exploitation vein, the abdominal cavity, intramuscular, in the blood vessel, subcutaneous, the injection at positions such as lymph node and new purposes such as oral, utilize external magnetic field that magnetic heating seed guiding or location are focused on tumor locus, realize new application process and magnetic steering magnetic heating seed thermotherapy, expansion using method and range of application improve localized accuracy and therapeutic effect.
Nano magnetic heating seed for thermotherapy and its production and use takes following scheme to realize: thermotherapy is characterized in that containing nano-magnetic powder, the surfactant of certain proportioning with the nano magnetic heating kind, and the weight proportion of nano-magnetic powder and surfactant is 1: 0～0.05.
Nano magnetic heating seed for thermotherapy preparation method: according to a certain ratio with in nano-magnetic powder, the surfactant water mixing, nano-magnetic powder: surfactant: the pure water weight proportion is 1: 0～0.05: 0.5～20, fully be uniformly dispersed by modes such as ultrasound wave or grinding or stirrings and be colloidal or suspension, after centrifugal or sedimentation, remove supernatant, and, remove unnecessary surfactant with the pure water washing; Add aqueous solutions such as pure water, normal saline and fully disperse to make injection nano magnetic heating seed for thermotherapy water preparation, nano-magnetic powder: surfactant: the aqueous solution weight proportion is 1: 0～0.05: 0.5～20; Or drying is made the powdery solid nano magnetic heating seed for thermotherapy.
Above nano-magnetic powder can adopt the above nano-magnetic powders such as nanometer ferromagnetism magnetic powder, nanometer ferrimagnetism magnetic powder and nanometer superparamagnetism magnetic powder of 5～10nm, 10～20nm, 20～40nm, 30～50nm, 50～100nm and 100nm.Surfactant comprises cetyl trimethyl ammonium bromide, sodium hexameta phosphate etc.
Nano magnetic heating seed for thermotherapy can directly use, for example pre-buried, injection tumor locus, oral, also can add aqueous solutions such as pure water or normal saline and make the use of injection nano magnetic heating seed for thermotherapy water preparation, and its water preparation can direct injection use or oral.The particle size of nano-magnetic powder can reach 5nm in the nano magnetic heating seed for thermotherapy, has very strong penetration power, can reach different parts in the body, occupation mode can adopt pre-buried or be expelled to tumor locus, also can select the injection at positions such as vein, abdominal cavity, intramuscular, blood vessel are interior, subcutaneous, lymph node and oral, utilize the penetrance of nano magnetic heating seed for thermotherapy and the guiding and the positioning action in magnetic field, nano magnetic heating seed for thermotherapy is assembled be positioned at tumor locus, make magnetic heating seed, magnetic hysteresis is given birth to the various oncologic application of thermal therapeutical.This has opened up new application process, has developed magnetic steering magnetic orientation magnetic heating seed thermotherapy method, and thermotherapy is made nano magnetic heating seed with magnetic heating seed, treats application in the various tumors in the magnetic heating seed heating therapy.Make the nano magnetic heating seed thermotherapy be applicable to the various oncotherapys of different parts different depth.The admixture surfactant is uniformly dispersed magnetic powder in the nano magnetic heating seed, and its technical method technology is simple, technology is reliable, easy to prepare.This measure can prevent that nano magnetic heating seed from disperseing inhomogeneous and reunion in using,, guarantee that therefore influence arrives the nano magnetic heating seed dosage and the therapeutic effect of tumor locus, treats safe and reliable.
The specific embodiment
The invention will be further described below with reference to embodiment.
Embodiment 1, preparation nano magnetic heating seed for thermotherapy
Taking by weighing particle diameter is the nano-magnetic powder 100g of 5～10nm, through with spilling smart sterilization, join in the 402g aqueous solution that contains 2g surfactant sodium hexameta phosphate, nano-magnetic powder: surfactant: the weight ratio of water is 1: 0.02: 4, with ultrasound wave or stirring nano-magnetic powder fully is uniformly dispersed then, after centrifugalize, removes supernatant, the washing of reuse clear water, remove unnecessary surfactant, adopt vacuum drying to make the powdery solid nano magnetic heating seed for thermotherapy.
Embodiment 2, preparation do not contain the nano magnetic heating seed for thermotherapy of surfactant.
Taking by weighing particle diameter is the nano-magnetic powder 100g of 50～100nm, through the high temperature sterilize sterilization, be incorporated in the pure water of 2000g nano-magnetic powder: the weight ratio of water is 1: 20, with ultrasound wave nano-magnetic powder is uniformly dispersed then, makes injection nano magnetic heating seed for thermotherapy water preparation.
Embodiment 3, preparation nano magnetic heating seed for thermotherapy water preparation
Taking by weighing particle diameter is magnetic powder 100g, the process high temperature sterilize of 20～40nm, add surfactant hexadecyldimethyl benzyl ammonium ammonium bromide 5g, join in the 50g pure water, nano-magnetic powder: surfactant: the weight ratio of water is 1: 0.05: 0.5, fully disperse to be colloidal by grinding or ultrasound wave, through the settlement separate supernatant of removing, remove unnecessary surfactant hexadecyldimethyl benzyl ammonium ammonium bromide with the pure water washing, add normal saline 2000g then and fully disperse to make the nano magnetic heating seed for thermotherapy water preparation.
The nano-magnetic powder of using among the above embodiment can adopt nanometer ferromagnetism magnetic powder, nanometer ferrimagnetism magnetic powder and nanometer superparamagnetism magnetic powder.
Embodiment 4, employing nano magnetic heating seed for thermotherapy treatment adenocarcinoma of lung
Get 16 of lotus human lung adenocarcinoma T739 mices, behind measurement and the calculating gross tumor volume, dividing equally at random by gross tumor volume is two groups, first group is matched group, every mouse tumor position injection pure water 0.5ml, second group every mouse tumor position injection 0.5ml contains the water preparation of 100mg the foregoing description 3 made nano magnetic heating seed for thermotherapy, two groups of mouse are all through inserting the varying magnetic field internal therapy 1 hour, treat and put to death animal after 10 days, separate tumor, take by weighing tumor weight, tumour inhibiting rate=(matched group tumor weight-treatment group tumor is heavy)/matched group tumor weight * 100%, significance test adopts the t check.The result shows that pure water group tumor weighs 7.4 ± 1.5g, adopts nano magnetic heating seed group tumor to weigh 3.5 ± 0.8g, and the tumour inhibiting rate of nano magnetic heating seed treatment group is 50.1%, and the P value is less than 0.01.These results show, adopt the nano magnetic heating seed thermotherapy to have extremely significant effect for tumor treatment, and nano magnetic heating seed for thermotherapy has significant application value in tumor treatment.
Toxicity test
Get each 10 of white mice and Cavia porcelluss, inject 0.5ml in white mice and Cavia porcellus abdominal cavity respectively and contain the nano magnetic heating seed for thermotherapy water preparation that 0.3g and 5ml contain 3g, do not see untoward reaction and weight loss after observing a week, after the execution, core, vitals sections such as brain, spleen, kidney, intestinal, liver do pathologic finding, show no obvious abnormalities.
Nano magnetic heating seed for thermotherapy of the present invention and its production and use is planted with traditional magnetic heat Sub-medicine is compared, and by the application of magnetic nanometer, surfactant and dispersing apparatus, makes Have the magnetic heating seed of good penetration, developed in vein, abdominal cavity, the flesh, blood vessel, skin The injection at the positions such as lower, lymph node and the new route of administration such as oral, and can utilize external magnetic field The magnetic heating seed guide-localization is gathered in tumor locus, realizes new administrated method and magnetic steering magnetic The heating seed thermotherapy expanded administrated method and range of application, improved the accuracy of location and controls Therapeutic effect. Zoopery shows that the nano magnetic heating seed thermotherapy has extremely significant result for the treatment of, and And have no side effect, nano magnetic heating seed is a kind of desirable magnetic heating seed, and it is used further Perfect magnetic heating seed thermotherapy method.
Claims (5)
1, a kind of nano magnetic heating seed for thermotherapy is characterized in that containing nano-magnetic powder, the surfactant of certain proportioning, and nano-magnetic powder and surfactant weight proportion are 1: 0～0.05.
2, a kind of nano magnetic heating seed for thermotherapy preparation method is characterized in that according to a certain ratio nano-magnetic powder, surfactant being mixed in pure water nano-magnetic powder: surfactant: the pure water weight proportion is 1: 0～0.05: 0.5～20; By ultrasound wave or grinding or stir fully to be uniformly dispersed and be colloidal or suspension, after centrifugal or sedimentation, remove supernatant, and, remove unnecessary surfactant with the pure water washing; Add aqueous solution and fully disperse to make injection nano magnetic heating seed for thermotherapy water preparation, nano-magnetic powder: surfactant: the aqueous solution weight proportion is 1: 0～0.05: 0.5～20; Or drying is made the powdery solid nano magnetic heating seed for thermotherapy.
3, nano magnetic heating seed for thermotherapy according to claim 1 and 2 and preparation method thereof is characterized in that nano-magnetic powder comprises nanometer ferromagnetism magnetic powder, nanometer ferrimagnetism magnetic powder and the nanometer superparamagnetism magnetic powder of 5～10nm, 10～20nm, 20～40nm, 30～50nm, 50～100nm.
4, nano magnetic heating seed for thermotherapy according to claim 1 and 2 and preparation method thereof is characterized in that surfactant comprises cetyl trimethyl ammonium bromide, sodium hexameta phosphate.
5, nano magnetic heating seed for thermotherapy preparation method according to claim 2 is characterized in that aqueous solution comprises pure water, normal saline.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01134012 CN1242820C (en) | 2001-10-09 | 2001-10-09 | Nano magnetic-heating seed for thermal therapy and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01134012 CN1242820C (en) | 2001-10-09 | 2001-10-09 | Nano magnetic-heating seed for thermal therapy and preparation method and application thereof |
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| CN1410137A CN1410137A (en) | 2003-04-16 |
| CN1242820C true CN1242820C (en) | 2006-02-22 |
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| CN 01134012 Expired - Fee Related CN1242820C (en) | 2001-10-09 | 2001-10-09 | Nano magnetic-heating seed for thermal therapy and preparation method and application thereof |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1733314A (en) * | 2004-08-11 | 2006-02-15 | 张阳德 | Process for preparing cerebrose albumin magnetic adriamycin nanometer particle |
| CN100372908C (en) * | 2005-07-15 | 2008-03-05 | 东南大学 | Production of nanometer heater for tumor magnetic thermal therapy |
| CN1772303A (en) * | 2005-10-25 | 2006-05-17 | 朱宏 | Nanometer magnetic powder-antibody targeting medicine for magneto thermical threrapy of malignant tumor |
| CN102523790B (en) * | 2011-09-30 | 2014-05-14 | 浙江大学 | Preparation method of magnetic powder anti-counterfeiting tobacco seed pellets, seed pellets and detection method of seed pellets |
| CN102523782B (en) * | 2011-09-30 | 2013-10-30 | 浙江大学 | Double fluorescent anti-counterfeit seed pellets, anti-counterfeit seeds and detection method |
| CN102577702A (en) * | 2011-10-28 | 2012-07-18 | 浙江大学 | Method for producing fluorescent magnetic powder dual anti-counterfeiting pelleted seed, pelleted seed and detection method |
| CN103058642A (en) * | 2012-12-31 | 2013-04-24 | 山东建筑大学 | Nanoscale hot seed material for microwave tumor thermotherapy and preparation method thereof |
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