CN1241934A - Hair treatment composition containing metal-aminoacid complex - Google Patents
Hair treatment composition containing metal-aminoacid complex Download PDFInfo
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- CN1241934A CN1241934A CN 97181122 CN97181122A CN1241934A CN 1241934 A CN1241934 A CN 1241934A CN 97181122 CN97181122 CN 97181122 CN 97181122 A CN97181122 A CN 97181122A CN 1241934 A CN1241934 A CN 1241934A
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Abstract
A rinse-off hair treatment composition for improved delivery of amino-acid to the hair and/or scalp comprising:(a) a particulate metal-amino acid complex;(b) at least one surfactant; and(c) a deposition aid.
Description
Technical field
The present invention relates to hair-treatment composition, the hair-treatment composition of rinse on can be after the use especially by scalp, and described compositions contains the amino acid active material that improves or nourish hair or root of hair.
Prior art
Known amino acid plays an important role in the growth of the nourishing of human body root of hair and human hair.For example, the keratin hydrolyzate is the conventional component of shampoo etc., and this hydrolyzate is the amino acid whose a kind of source of free form and peptide form.Many patent applications have been described a series of aminoacid and have been used for the treatment of alopecia and other skin, scalp and hair disease at local coating in washing liquid or analeptic.
Yet, active component must be passed to the useful effect that site of action could obtain to float type hair treatment agent, and the beneficial effect of used material (as aminoacid) often being restricted, this major part that is attributed in them will be removed at rinse stage.
The common methods that addresses this problem is the active component concentration that prolongs in coating time and the increase preparation.For example, people such as Franz have confirmed that in Fundam.Appl.Toxicol.21 (1993) 213-221 as the function of coating dosage, the human body product preparation of different genera prototype has different infiltration stage systems.But this also is not suitable for daily service condition, and the prolongation of time of contact will cause the damage of barrier.
Therefore, need to improve the aminoacid transfer function that floats in the type hair treatment.
Metal-aminoacid complex is known in the prior art and effective.Lot of documents thinks that as a kind of approach that metal is provided, this type of complex can be used as food supplement and is administered to animal in nontoxic mode.Aminoacid can reduce the toxicology character of heavy metal.In the human health care field, (zinc-amino acid conjugates is WO92/10178) and in the antiinflammatory frost (SU 1382477) metal-aminoacid complex to be applied to hair coloring compositions (copper of cysteine or zinc salt, US 4 173 453), pruritus.But they all do not describe the improvement to the deposition/fastness of the amino acid moiety in the topical preparation.GB 937 362 has proposed to be used for the compositions of skin, hair and manicure or growth, the chemical compound that contains one or more a-amino acid magnesium in the said composition, the document thinks that such amino acid residue is the carrier that specifically magnesium is incorporated in skin and the hair cell.US 4,652, and 455 disclose a kind of non-rinsing type hair conditioning products, are added with " the releasing the zinc component " of replenishing zinc to hair fiber in this product.This releases the amino acid complex that zinc compound can be a zinc, but preferred zinc-albumen or zinc keratin.
Find, float amino acid whose deposition in the type hair-treatment composition by in compositions, mixing the aminoacid that becomes complex with metal ion, can improving.Because such method has been improved the transfer function of aminoacid nutrient on targeting substrate (being hair and/or scalp) in the per unit dosage, thereby provide the superiority of performance and cost aspect.
Summary of the invention
On the one hand, the invention provides a kind of improve the transfer function of aminoacid on hair and/or scalp float the type hair-treatment composition, said composition contains:
(a) a kind of particle metal-amino acid complex;
(b) at least a surfactant; With
(c) deposition aid.
On the other hand, the invention provides the method that amino acid whose deposition in the type hair-treatment composition is floated in a kind of raising, this method comprises: described aminoacid is incorporated in the compositions with particle metal-amino acid complex form.
The third aspect the invention provides the application in the amino acid whose deposition of particle metal-amino acid complex in the type hair-treatment composition is floated in raising.
Detailed Description Of The Invention and preferred embodiment
Aminoacid
The example of the amino acid moiety in described particle metal-amino acid complex is to derive from, and comprising:
Arginine
Aspartic acid
Citrulline
Cysteine
Cystine
Cystathionie
Glutamic acid
Glutamine
Glycine
Isoleucine
Lysine
Methionine
Ornithine
Serine and
Valine
Preferred especially cysteine, arginine, serine, glutamic acid, glutamine, isoleucine, lysine, methionine and valine.
The present invention also can adopt described amino acid whose derivant.For example, comprise wherein amino acid whose free amine group (NH
2) derivant of being modified by one or more following groups:
(i) acyl group, N-alkanoyl (alkanoyl) for example, wherein alkanoyl partly has 3 to 20 carbon atoms, and the alkyl chain of preferred 4 to 10 carbon atoms is as N-bytyry, N-caproyl and N-caprylyl;
(ii) ester group, for example wherein alkyl is to contain 1 to 20 carbon atom, those ester groups of the straight chained alkyl of preferred 1 to 4 carbon atom are as methyl, ethyl and n-pro-pyl;
(iii) amino acid residue; With
The peptide residue that (iv) contains 2 to 8 amino acid residues.
The present invention can also adopt the mixture of aminoacid or derivatives thereof.Itself also can contain aminoacid inequality the unimolecule metal complex.
Metal ion
Preferred metal ion is divalent at least.
The example of the metal ion in resulting particle metal-amino acid complex comprises: Fe, Cu, Ca, Mn, Sn, Ti and Zn.Most preferred metal ion is Zn; This is to consider from the protective action to hair damage.
The present invention also can adopt the mixture of metal ion.And, can contain more than one metal ion with the metal complex in a part, and these metal ions can be identical or different.
In the preferred present composition, particle metal-amino acid complex is cysteine zinc or zinc glutamate or both mixture.
Granularity
The particle mean size of the metal-aminoacid complex in the present composition is in 0.05 to 50 micron scope.Our experiment is (with the fluorescent microspheres of different sizes as the model granule, utilization checks that with burnt laser scanning microscope the particle deposition on the skin develops) show, granularity constitutes influence to the degree and the position of deposition, and arriving hair follicle for targeted delivery, preferred particle mean size is 3 to 10 microns.
Be blended in that the amount of the particle metal-amino acid complex in the present composition is fit to be composition total weight about 0.001% to about 10%, more preferably from about 0.1% to about 5% (weight).
Surfactant
Compositions of the present invention contains at least a surfactant, and it is preferably from anion, cation, nonionic, both sexes and zwitterionic surfactant, and their mixture.
Desirable especially hair-treatment composition of the present invention is a shampoo Compositions, wherein has at least a kind of surfactant that clean result is provided.The washing performance surfactant is preferably from anion, nonionic, both sexes and zwitterionic surfactant, and their mixture.
The anion surfactant that is suitable for comprise alkyl sulfate, alkyl ether sulfate, alkylaryl sulfonate, alkanoyl isethionate, alkyl succinate, alkyl sulfo succinate, N-alkanoyl (alkoyl) sarcosinate, alkylphosphonic, alkyl ether phosphate, alkyl ether carboxy acid salt and alpha-alkene sulfonate, especially their sodium salt, magnesium salt, ammonium salt, list-, two-and triethanolamine salt.Described alkyl and acyl group contain 8 to 18 carbon atoms usually and can be undersaturated.Can contain 1 to 10 oxirane or propylene oxide units among the described alkyl ether sulfate of per 1 molecule, alkyl ether phosphate and the alkyl ether carboxy acid salt, and contain 2 to 3 ethylene oxide units in preferred per 1 molecule.
The examples of anionic surfactants that is suitable for comprises oleoyl sodium succinate, lauryl 2-Sulfosuccinic acid ammonium, ammonium lauryl sulfate, dodecylbenzene sodium sulfonate, DBSA triethanolamine salt, cocoyl sodium isethionate, lauroyl sodium isethionate and N-sodium N-lauroyl sarcosinate.Most preferred anion surfactant is sodium lauryl sulfate, lauryl sulfate triethanolamine salt, single lauryl nitranol salt, 1EO, 2EO and 3EO lauryl ether sodium phosphate, lauryl ammonium phosphate and 1EO, 2EO and 3EO Zetesol AP.
Be applicable to that the ionic surfactant pack of the present composition draws together the aliphatic of straight or branched (C8-C18) uncle or secondary alcohol or phenol and oxyalkylene, generally be the condensation product of oxirane, and have 6 to 30 ethylene oxide groups usually.That other ionic surfactant pack that are suitable for are drawn together is single-or two-alkanolamide.The example comprise cocoyl single-or two-glycollic amide and cocoyl list-isopropanol amide.
The both sexes and the zwitterionic surfactant that are suitable in the present composition comprise: alkyl amine oxide, alkyl betaine, alkylamidoalkyl CAB, alkyl sulfobetaines (sulfobetaines), alkyl glycinate (ester), alkyl carboxyl glycinate (ester), alkyl both sexes propionate, alkyl both sexes glycinate, alkylamidoalkyl propyl hydroxy sulfobetaines, acyl taurine salt (ester) and acyl glutamate (ester), wherein said alkyl and acyl group have 8 to 19 carbon atoms.The example comprises: lauryl amine oxide, coco dimethyl sulfopropyl betaine and preferred lauryl betaine, cocamido propyl betaine and cocos nucifera oil both sexes sodium propionate.
The content of described surfactant in shampoo Compositions of the present invention is 0.1% to 50% (weight), preferred 0.5% to 30% (weight).
Hair-treatment composition of the present invention also can be taked the form of hair care composition, and said composition preferably contains one or more cationic surfactants.Why preferred especially the employing is because these components can be brought conditioning benefits for hair to cationic surfactant.
The example of cationic surfactant comprises:
Quaternary ammonium hydroxide, for example Tetramethylammonium hydroxide, alkyl trimethyl ammonium hydroxide, wherein said alkyl has about 8 to 22 carbon atoms; Concrete example such as octyl group trimethylammonium hydroxide, dodecyl trimethylammonium hydroxide, cetyltrimethylammonium hydroxide, octyldimethyl benzylic hydrogens amine-oxides, decyl dimethyl benzyl ammonium hydroxide, stearyl dimethyl benzyl ammonium hydroxide, two dodecyl dimethyl ammonium hydroxide, two octadecyl dimethyl hydrogen amine-oxides, Adeps Bovis seu Bubali trimethylammonium hydroxide, cocos nucifera oil trimethylammonium hydroxide and corresponding salt, for example chloride.
Cetyl hydroxide pyridine and salt thereof, for example chloride
Quaternium-5
Quaternium-31
Quaternium-18
And their mixture.
In Wo 2008069000 of the present invention, the content of cationic surfactant preferably accounts for 0.01% to 10% of described composition weight, and more preferably 0.05% to 5%, most preferably 0.1% to 2%.
Deposition aid
According to the present invention, described hair-treatment composition contains and is applicable to the particulate macromolecular water-soluble deposition aid of metal-aminoacid complex.So-called " deposition aid " is meant that a kind of metal-aminoacid complex granule that improves is at the last sedimentary reagent of target position (being hair and/or scalp).
The content of described deposition aid generally should be 0.01% to 5%, and is preferred about 0.05% to 1%, more preferably from about 0.08% level to about 0.5% (weight).This deposition aid can be a homopolymer, or is made of the monomer of two or more types.The molecular weight of described polymer in 5000 and 10 000 000 scope, generally is 10 000 usually at least, and preferred 100 000 to about 2 000 000 scope.Such polymer should have cationic nitrogen-containing group, for example quaternary ammonium or protonated amino, or their mixture.
The cationic charge density that has been found that deposition aid must be 0.1meq/g at least, preferably about 0.8meq/g or higher, and this charge density is defined as having the inverse of the unitary molecular weight of polymer monomer of an electric charge.This cationic charge density should be no more than 4meq/g, preferably is lower than 3meq/g, more preferably below 2meq/g.Can utilize conductimetry to measure this charge density, and this charge density should be in the above-mentioned scope under using required pH condition, it generally is about 3 to 9, preferably between 4 to 8.
Cationic nitrogen-containing group normally exists as the substituent group on the part in all monomeric units of deposition aid.Therefore, when polymer was not homopolymer, it can contain nonionic spacer monomers unit.This polymer is in CTFA cosmetic conduct and learning composition catalogue, describes in the 3rd edition.With respect to the selection of the unitary ratio of non-ionic monomer the cationic charge density of polymer is in the afore mentioned rules scope cation.
The cationic deposition aids that is suitable for comprises, for example, contain the vinyl monomer of cationic amine or quaternary ammonium degree of functionality and the copolymer of water solublity spacer monomers, described water solublity spacer monomers for example is (methyl) acrylamide, alkyl and dialkyl group (methyl) acrylamide, (methyl) alkyl acrylate, vinyl caprolactone and ethenyl pyrrolidone.The monomer that described alkyl and dialkyl group replace preferably has the alkyl of C1-C7, more preferably C1-3 alkyl.Other interval base that is suitable for comprises vinyl esters, vinyl alcohol, maleic anhydride, propylene glycol and ethylene glycol.
Described cationic amine can be primary, the second month in a season or tertiary amine, and this depends on the particular type and the pH of compositions.Usually preferred secondary amine and tertiary amine, especially preferred tertiary amine.
Vinyl monomer that amine replaces and amine can be with the form polymerizations of amine, and with after quaternization changes ammonium into.
The cationic amino and the quaternary ammonium monomer that are suitable for comprise, for example: vinyl compound, it can be by propenoic acid dialkyl aminoalkyl ester, alkyl methyl propenoic acid dialkyl amino ester, acrylic acid alkyl monosubstituted amino Arrcostab, methacrylic acid alkyl monosubstituted amino Arrcostab, trialkyl methacrylic acid oxygen (methacryloxy) alkylammonium salt, trialkyl propylene acyloxy alkylammonium salt, diallyl quaternary ammonium salt; With contain the vinyl quaternary ammonium monomer that the ring-type cation contains azo-cycle (for example pyridine, imidazoles and quaternised pyrrolidine), for example alkyl vinyl imidazoles, alkylvinylpyridines and alkyl vinyl pyrrolidinium.These monomeric moieties are low alkyl group (for example C1-C3 alkyl) preferably, more preferably C1 and C2 alkyl.
Be applicable to that amine substituted ethylene base monomer of the present invention comprises: propenoic acid dialkyl aminoalkyl ester, methacrylic acid dialkyl aminoalkyl ester, dialkyl aminoalkyl acrylamide and dialkyl aminoalkyl Methacrylamide, the preferred C1-C7 alkyl of wherein said alkyl, more preferably C1-C3 alkyl.
Described deposition aid can contain derived from amine-and/or the mixture of the monomeric unit of the monomer of quaternary ammonium-replacement and/or compatibility spacer monomers.
The deposition aid that is suitable for comprises, for example: the cationic copolymer (being called season hydroxy ethyl fiber-16 (Polyquaternium-16) in the industry of cosmetics, toilet articles and fragrance association " CTFA ") of 1-vinyl-2-pyrrolidine and 1-vinyl-3-methyl-imidazole salts (for example chloride salt); The copolymer of 1-vinyl-2-pyrrolidine and dimethylaminoethyl methacrylate (in the CFTA industry, being called season hydroxy ethyl fiber-11 (Polyquaternium-11)); The cationic polymer that contains the diallyl quaternary ammonium comprises, for example, and dimethyl diallyl ammonium chloride homopolymer (being called season hydroxy ethyl fiber 6 (Polyquaternium 6) in the industry (CFTA)); Contain the inorganic acid salt of the amino-Arrcostab of the homopolymer of unsaturated carboxylic acid of 3 to 5 carbon atoms and copolymer, for example United States Patent (USP) 4,009, those disclosed in 256; And cationic-type polyacrylamide, as those disclosed in UK Patent Application 9403156.4. number.
Other cationic deposition aid that is suitable for comprises the cationic guar gum derivant, for example guar gum Hydroxyproyl Trimethyl quaternary ammonium chloride (guar hydroxypropyltrimoniumchloride) (Celanese Corp. sells with its Jaguar trade mark series).
Such as: JAGUAR C13S, it has low cation group and the high viscosity that replaces.JAGUAR C15 has medium substitution value and low viscosity; JAGAR C17, high substituted degree and high viscosity; JAGUAR C16 is a kind of cationic guar gum derivant of hydroxypropylation, and it contains low-level substituted radical and cationic quaternary ammonium base; And extremely transparent JAUGAR 162 is to have low degree of substitution and moderately viscous guar gum.
Desirable deposition aid is selected from: contain the series of cationic-type polyacrylamide, and the cationic guar gum derivant.Particularly preferred deposition aid is that cationic charge density is the Jaguar C13S of 0.8meq/g.The material of other particularly suitable comprises: Jaguar C15, Jaguar C17, Jaguar C16 and Jaguar C162.
Suspending agent
The present composition can also randomly contain 0.1% to 5% suspending agent in addition.Its example is cross-linked copolymer, heteropolysaccharide natural gum and the crystal type long acyl derivant of the copolymer of polyacrylic acid, acrylic acid cross linked polymer, acrylic acid and hydrophobic monomer, the copolymer that contains carboxylic acid monomer and acrylate, acrylic acid and acrylate.Described long acyl derivant should be selected from glycol stearate, contain the alkanolamide and composition thereof of the fatty acid of 16 to 22 carbon atoms.There are Carbopol 420, Carbopol 488 or Carbopol 493 in polyacrylic commercially available prod.The present invention also can adopt the cross linked polymer of acrylic acid and multifunctional reagent, and there are Carbopol 910, Carbopol 934, Carbopol 940, Carbopol 941 and Carbopol 980 in its commercially available prod.The suitable example that contains the copolymer of carboxylic acid monomer and acrylate is Carbopol 1342.All Carbopol materials sell by Goodrich company and its trade mark is Carbopol.Other suspending agent that is suitable for is di-H Adeps Bovis seu Bubali phthalic amide (Stepan Chemical Co. sells with the trade mark of Stepan TAB-2).
The acrylic acid that is suitable for and the cross linked polymer of acrylate are Pemulen TR1 or Pemulen TR2.The heteropolysaccharide natural gum that is suitable for is xanthene glue, for example the Kelzanmu product sold.
Conditioner
Hair-treatment composition of the present invention also can randomly contain one or more conditioners, as among those skilled in the art known those.Described conditioner can comprise: polysiloxanes, protolysate, quaternised protolysate, and other has the known materials of hair conditioning character in this area.Polysiloxanes is most preferred conditioner.
The polysiloxanes that is suitable for comprises: volatility and nonvolatile polysiloxanes, the polysiloxanes of for example poly-alkylsiloxane, polyoxyethylene alkyl aryl radical siloxane, siloxanes natural gum and resin, Cyclomethicone, amido functional group, quaternary ammonium polysiloxane alkane and composition thereof.Silicone oil is particularly preferred hair conditioner.Described polysiloxanes can be the form of light viscosity oil, can contain full-bodied oil or natural gum in this oily solution.In addition, heavy viscous material also can adopt the emulsion form in the water.Described emulsion is full-bodied oil or is in the interior gum-solution of light viscosity oil.The granularity of oil phase is between the arbitrary value of 30 nanometers to maximum 20 microns mean particle size range.
Described silicone oil is suitably for particle mean size below 20 microns and preferably at the polydimethylsiloxane below 2 microns.When polysiloxanes concentration was identical, less granularity guaranteed that the polysiloxanes conditioner has more uniform distribution in compositions.Preferably adopt viscosity 1,000,000-20,000, the polysiloxanes in the 000cst scope.Polysiloxanes is suitably for the polysiloxanes of emulsion polymerisationization, because can really make the easier processing of polysiloxanes of very high viscosity like this.Polysiloxanes also can be crosslinked.
The protolysate that is suitable for comprises the animal proteinum (trade name with LAMEQUAT L is sold) of dodecyl dimethyl quaternary ammonium (dimomium) hydroxypropyl hydrolyzable aminosilane, and contains the amino acid whose hydrolysis of keratin of band sulfur (selling with CROQUAT WKP trade name).
Aliphatic alcohol
The another kind of component that can randomly be blended in the hair-treatment composition of the present invention is the aliphatic alcohols material.These materials are at care composition of the present invention, and the use that especially contains in the care composition of one or more cationic surfactant materials is useful especially.Can affirm aliphatic alcohol and cationic surfactant share according to having superiority in care composition, because this share causes forming cationic surfactant and can be dispersed in wherein lamellar phase.
Preferred aliphatic alcohol contains 8 to 22 carbon atoms, more preferably 16 to 20 carbon atoms.The example of preferred fat alcohol is: hexadecanol and stearyl alcohol.The application of this material also helps the overall conditioning performance of the present composition.
The content of aliphatic alcohol material normally described composition weight 0.01% to 10%, preferred 0.1% to 5%.Cationic surfactant preferred 10: 1 to 1: 10 with respect to the weight proportion of aliphatic alcohol, more preferably 4: 1 to 1: 8, most preferably 1: 1 to 1: 4.
Water
Hair-treatment composition of the present invention is preferably based on water.Said composition is fit to contain the water that accounts for composition total weight about 20% to about 99%.
Using method
Compositions of the present invention is preferably floated the type compositions, promptly be fit to be coated on hair and/or the scalp, keep one section reasonable time and and then the water rinse remove.Therefore, shampoo is the particularly preferred product form of the present composition.
Other optional components
According to the types of compositions of being taked, the present composition can contain one or more and be usually used in annexing ingredient in the hair treatment preparation.Such annexing ingredient comprises: opacifier, for example distearyl acid polyethylene glycol ester and glycol stearate; Macromolecule lattice (lattice); Other antimicrobial; Foaming agent; Spice; Coloring agent; Antiseptic; Viscosity modifier; Protein; Polymer; Buffering or pH regulator agent; Wetting agent; Medicinal herbs or other plant extract and other natural component.
The present invention will be further specified by following non-limiting examples, wherein:
Fig. 1: be the free form in the shampoo substrate and the percentage deposition agent spirogram of cysteine on external Corii Sus domestica skin of metal complex form.
Embodiment
Material
Prepare to be used for the radio-labeled of synthetic cysteine and the cysteine zinc of non-radioactive labelling by following method: under the condition of pH7, be present in the L-[in the stabilizing solutions that contains potassium acetate
35S]-cysteine (＞1000Ci/mmol) (20mM) and dithiothreitol, DTT (5mM) all available from Amersham Intermational Plc (Little Chalfont, U.K.).L-cysteine (about 98%) available from Sigma Chemical Co. (St Louis, M.O., U.S.A.).
DulbeccoShi phosphate buffered saline (PBS) (10X concentration) and penicillin/streptomycin (5000IU/ml/5000 μ g/ml) available from life Engineering Co., Ltd (Paisley, U.K.).Anhydrous D-(+)-glucose available from Sherman chemistry company limited (Sandy, U.K.).Buffer is prepared with distilled water.
Method
1. cysteine zinc is synthetic
Basic zinc carbonate (10 gram) is joined in the aqueous solution (14.92g/100ml) of cysteine and reflux 16 hours when stirring.Filter to collect and to obtain yellow-white crystalline solid, wash with water and at air drying.Utilize the empirical formula of the complex that thermal gravimetric analysis obtains to be: Zn[SCH
2CH (NH
2) CO
2].By with the Fourier transform infrared spectroscopy of this product and this complex with reference to spectrum (Shindo ﹠amp; Brown, J.Am.Chem.Soc.87 (1965) 1904-1909) compares and to confirm this empirical formula.
2. cysteine zinc size reduces
2.1
With the suspension (1%w/v) of cysteine zinc in distilled water with ultrasonic probe (Soniprep, MSE, U.K.) sonication 5 minutes under peak swing and in the ice.
2.2 laser light scattering
The sonication suspension of aliquot is placed Malvern Mastersizer.The 300mm lens that will have a 3mm optical path length pond link to each other with little sample display device, and this installs continuous stirring.Analyze light scattering data with sample reveal codes (presentation code) 0700.
Utilizing computer spreadsheet program (the Excell of Microsoft) to prepare mass accumulation distributes.Directly obtain granularity data from the Mastersizer outfan.
3. skin deposits experiment
3.1 the preparation of preparation
In order to calculate the free cysteine with specified amount complex materials equivalent, can be with Zn[SCH
2CH (NH
2) CO
2], that is to say that cysteine accounts for 64.96% of this formula gross weight as the empirical formula of cysteine zinc complex.
Free cysteine and the difference of complexation cysteine in this detection method are meant: contain the free cysteine preparation that comprises the radio-labeled cysteine and contain the complexation cysteine but without any the difference of radiolabeled preparation.
Free and cysteine complexation are made two types shampoo.A kind of shampoo contains deposition aid-JAGUAR and another kind of shampoo does not contain.Described shampoo has following prescription:
| Component %w/w | ||||
| The preparation of free cysteine | The preparation of complexation cysteine | |||
| Contain deposition aid | Do not contain deposition aid | Contain deposition aid | Do not contain deposition aid | |
| Cysteine | 1.38 | 1.38 | ||
| The cysteine equivalent | 1.38 | 1.38 | ||
| Deposition aid: JAGUAR C13S (guar gum Hydroxyproyl Trimethyl chlorination quaternary ammonium) | 0.10 | - | 0.10 | - |
| Sodium lauryl sulphate | 14.00 | 14.00 | 14.00 | 14.00 |
| Cocamidopropyl betaine | 2.00 | 2.00 | 2.00 | 2.00 |
| Dimethiconol and TEA-dodecyl benzene sulfonate | 1.60 | 1.60 | 1.60 | 1.60 |
| Sodium benzoate | 0.50 | 0.50 | 0.50 | 0.50 |
| Amplitude 484 | 0.50 | 0.50 | 0.50 | 0.50 |
| Diglycol stearate (with) dodecyl-4 (with) cocoamidopropyl | 8.00 | 8.00 | 8.00 | 8.00 |
| Sodium chloride | 1.00 | 1.00 | 1.00 | 1.00 |
| Citric acid | To pH 4.5-5.0 | To pH 4.5-5.0 | To pH 4.5-5.0 | To pH 4.5-5.0 |
| Water | To 100 | To 100 | To 100 | To 100 |
Condition when simulation is used as much as possible should be with shampoo 10 times of dilute with waters before being coated on skin.This 10 times of diluents are the diluents when imitating people to be coated in shampoo on the wet hair.
For the preparation of each free cysteine, with 45.4 μ l L-[
35S]-the 0.185%w/v L-cysteine of cysteine (preparation the same day be 480 μ Ci), 30 μ l shampoos and 224.61 μ l mixes in the little centrifuge tube of plastics.Make the shampoo of 10 times of the dilutions of 300 μ l thus, such shampoo is applicable to the metered dose in 10 diffusion cells; Each dosage contains the L-[of 40 μ Ci
35S]-cysteine, its volume is that the concentration of 25 μ l and cysteine is 1.38%w/w.
For the preparation of each complexation cysteine, the 1ml shampoo is mixed with 6.88ml water with the sonication cysteine zinc suspension liquid of 2.12ml0.212%w/v.Make the shampoo of 10 times of 10ml dilutions thus, it has the semicystinol concentration that equals 1.38%w/w.The ultrasonic probe legal system that utilization is described in detail in 2.1 is equipped with cysteine zinc suspension liquid.Detect the granularity of the cysteine that (aforementioned 2.2) diminish with laser light scattering method.The conjugate that detects the cysteine zinc that major part diminishes is 8.27 μ m.It is unimodal that particle size distribution is; 10% particle diameter is less than 2.91 μ m, and 90% granule is less than 22.46 μ m.
3.2 the preparation of skin
Adopt the skin of back of the pig at two monthly ages to experimentize.At first use 75% washing with alcohol skin.Do like this is in order to remove sebum.Use electric clippers (Oster, U.S.A.) unhairing subsequently.With dissecting knife (Raymond ﹠amp; Lamb) wipe subcutaneous fat off.Subsequently ready skin freezing is stored till using.On the same day of experiment, this skin to be thawed, skin treatment is into about thickness (the Deca Dermatome of 500 μ m, Depuy Healthcare, Leeds, U.K.), and subsequently it is swum in that (pH 4, contain 0.1% glucose, DMPBS) in the improved phosphate buffered saline (PBS) of DubeccoShi.
3.3 skin deposits test
(N.J. U.S.A.) carries out diffusion test for Crown Bioscientific Inc, Somerville with Teflon circulation type diffusion cell.Diffusion cell has reception volume and the 0.38cm of 130 μ l
2Exposed surface area.It is that this heat block heats by circulator bath on 37 ℃ the metallic aluminium heat block (Posiblock diffusion cell heater, Crown Glass Co.) that diffusion cell is remained on temperature.In this way, the surface temperature of skin can be maintained at nearly 32 ℃, normal skin surface temperature.Be filled with DMPBS in the receiving chamber to keep the advantages of good skin hydration.
For each of four kinds of preparations, 10 times of dilution preparations of its 25 μ l are coated on the skin.The volume of used dosage is according to 700cm
2The long-pending basis that generally need apply the 5g product of scalp surface is selected, and therefore the dosage of undiluted shampoo on per unit area is 7.1mg/cm
2, and every 0.38cm
2On dosage be 2.7 μ l approximately.This equates 10 times of cut-back products of about 25 μ l.
Adopt 25 μ l the displacement pipet (Anachem, Luton, U.K.) quantitative.Above-mentioned preparation is applied to 1 minute, and rinses with 10 * 0.5ml DMPBS.Buffer is coated on the skin also with disposable pipet taking-up with the 1mlGilson pipet.With skin surface rinsing three times, each washing is all absorbed and repaste applies buffer.
After the washing, skin was placed in the diffusion cell 2 hours.From each diffusion cell, take out skin samples, prune the skin surface that applied down with a secondary shears.In the radio-labeled test, skin samples is dissolved in the distilled water solution of 2ml 90%v/vSoluene-350 .Sample is spent the night before scinticounting 50 ℃ of dissolvings, the solubility sample is mixed with 16mlHionic-Fluor (Packard Instrument Co.).
In the radio-labeled test, specimen in use is all at Beckman LS6000IC liquid scintillation counter (Beckman Instruments, Inc., Fullerton, C.A., U.S.A.) last counting.
3.4 atomic absorption spectrography (AAS)
Barren and skin samples (general 10 to 20 milligrams) that handled are weighed in the PTFE sleeve pipe with threaded top, and add the 0.25ml concentrated nitric acid.Sleeve pipe is screwed, be built in the rustless steel digestion vessel and and heated 2 hours down at 140 ℃.After the cooling, digest is diluted to 10ml with deionized water.
With flame atomic absorption spectrometry under following condition by with the known standard thing analysis bank is recently knitted digest: air/acetylene flame, wavelength=213nm stitches wide=0.7nm.
The result
The data of having summarized the skin deposits effect in the table 1.The meansigma methods of numeric representation 8 to 10 parallel tests.Numeric representation 2x standard error in the bracket.
Table 1
| The % deposit dose | ||
| Do not contain JAGUAR | Contain JAGUAR | |
| Free cysteine | 0.51(0.26) | 0.83(0.31) |
| Cysteine zinc | 1.81(0.98) | 4.85(1.81) |
Conclusion
Statistical the analysis showed that: for the disposition of two kinds of cysteine zinc, the zinc content in the skin samples of measuring by atomic absorption spectrography (AAS) is apparently higher than the skin value (p＜0.05, Student's T Test is etc. variance) of blank.In addition, the deposition of cysteine because of the adding of Jaguar deposition aid be improved significantly (p＜0.05, Student's T Test is etc. variance).As expected, Jaguar is for the deposition did not influence (p＜0.05, Student's T Test is etc. variance) of free cysteine.
Claims (9)
- One kind improve that aminoacid is passed to hair and/or scalp float the type hair-treatment composition, said composition contains:(a) particle metal-amino acid complex;(b) at least a surfactant; With(c) deposition aid.
- 2. the described compositions of claim 1, wherein said metal ion has divalent at least.
- 3. claim 1 or 2 compositions, wherein said aminoacid is selected from cysteine, arginine, serine, glutamic acid, glutamine, isoleucine, lysine, methionine, valine, and their mixture.
- 4. each described compositions of claim 1 to 3, wherein said particle metal-amino acid complex is cysteine zinc or zinc glutamate, or both mixture.
- 5. require each described compositions according to aforesaid right, wherein the particle mean size of particle metal-amino acid complex is 3 to 10 microns.
- 6. require each described compositions according to aforesaid right, wherein said composition is a kind of shampoo Compositions, it contains the washing performance surfactant of 0.5% to 30% (weight), and this surfactant is selected from anion, nonionic, both sexes and zwitterionic surfactant and composition thereof.
- 7. require each described compositions according to aforesaid right, wherein said deposition aid is selected from cationic-type polyacrylamide and cationic guar gum derivant.
- 8. the method for amino acid whose deposition in the type hair-treatment composition is floated in a raising, and this method comprises: the aminoacid of sneaking into particle metal-amino acid complex form in said composition.
- 9. particle metal-amino acid complex floats application in the amino acid whose deposition in the type hair-treatment composition in raising.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97181122 CN1241934A (en) | 1996-10-31 | 1997-10-24 | Hair treatment composition containing metal-aminoacid complex |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9622659.2 | 1996-10-31 | ||
| CN 97181122 CN1241934A (en) | 1996-10-31 | 1997-10-24 | Hair treatment composition containing metal-aminoacid complex |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1241934A true CN1241934A (en) | 2000-01-19 |
Family
ID=5178100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 97181122 Pending CN1241934A (en) | 1996-10-31 | 1997-10-24 | Hair treatment composition containing metal-aminoacid complex |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1241934A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186382A (en) * | 2012-12-19 | 2018-06-22 | 高露洁-棕榄公司 | Zinc and amino-acids halide complex and cysteine |
| CN113873986A (en) * | 2019-06-28 | 2021-12-31 | 宝洁公司 | Improving the stability of zinc pyrithione in oxidizing environments such as scalp sebum fluids |
-
1997
- 1997-10-24 CN CN 97181122 patent/CN1241934A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186382A (en) * | 2012-12-19 | 2018-06-22 | 高露洁-棕榄公司 | Zinc and amino-acids halide complex and cysteine |
| CN104853813B (en) * | 2012-12-19 | 2018-07-10 | 高露洁-棕榄公司 | Zinc and amino-acids halide complex and cysteine |
| CN113873986A (en) * | 2019-06-28 | 2021-12-31 | 宝洁公司 | Improving the stability of zinc pyrithione in oxidizing environments such as scalp sebum fluids |
| CN113873986B (en) * | 2019-06-28 | 2024-04-26 | 宝洁公司 | Improving stability of zinc pyrithione in oxidizing environments such as scalp sebum fluids |
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