CN1237411A - Toothpaste for preventing dental calculus - Google Patents
Toothpaste for preventing dental calculus Download PDFInfo
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- CN1237411A CN1237411A CN 98109075 CN98109075A CN1237411A CN 1237411 A CN1237411 A CN 1237411A CN 98109075 CN98109075 CN 98109075 CN 98109075 A CN98109075 A CN 98109075A CN 1237411 A CN1237411 A CN 1237411A
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- toothpaste
- tartar
- pyrophosphate
- prevention
- dental calculus
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Abstract
The present invention relates to a dental cleaning agent preparation, in particular, it is a toothpaste capable of preventing formation of dental calculus, and is made up by adding the medicine capable of preventing formation of dental calculus in toothpaste. The use of said invented toothpaste can attain the goal of preventing periodontal disease.
Description
The prevention tartar toothpaste of the present invention section of belonging to cleaning agent preparation.
Abroad, just begin one's study and suppress the formation of tartar with chemicals, obtained good effect in the research application facet of going the tartar cleaning agent at present over past ten years; Domestic soon relevant at present report still belongs to blank, existing medicated toothpaste such as toothpaste with fluoride, and the Chinese medicine Compound formula of toothpaste, it mainly acts on is antiphlogistic antibacterial, caries prevention, antiallergic, the generation of tartar is not all had preventive effect.
Periodontal is human one of the widest disease that distributes, all have popular all over the world, children more than half and nearly all adult suffer from gingivitis, periodontitis to some extent or the two has concurrently, periodontal sufferer rate height, be the main cause of losing tooth, and tartar is the key factor that causes that periodontal is very important.Be the protection periodontal health, everyone should regularly clean one's teeth, and the cleaning oral cavity tartar is mainly removed by machinery at present, wastes time and energy, and China is populous, is difficult to accomplish that everybody regularly cleans one's teeth to Medical-Dental Division.
The objective of the invention is to develop in toothpaste matrix and to add the toothpaste that a kind of chemicals is made the prevention tartar, the custom that people are brushed teeth by the toothpaste of daily this prevention tartar reaches cleaning oral cavity, and the purpose of periodontal health is protected in the generation of prevention tartar.
To over past ten years abroad about chemicals suppress tartar research 20 surplus piece reported literature analyze and research and think: pyrophosphate, zinc salt, two chlorobenzene oxygen chlorophenol, these chemicalses of diphoponate have the effect that tartar forms that suppresses.The tartar main component is hydroxyapatite and white phosphorus lime stone, OCP and calcium hydrogen phosphate.Pyrophosphate is to scratch unsetting calcium phosphate to the hydroxyapatite transformation link by dried, reaches the formation that stops calcification.Zoopery shows that pyrophosphate can have the effect that reduces tartar formation, and the nucleus that can suppress calcium phosphate and microstructure occurs, and causes dental plaque and other precipitate to be difficult the denidation calcification, forms thereby suppress tartar.
By lithodialysis test, formula test, laboratory test clinical research, confirmation.Wherein pyrophosphate goes the tartar effect obvious.
Prevention tartar formulation of toothpaste is:
Tetrasodium pyrophosphate (Na
4P
2O
7.10H
2O) 0.48 gram.
Analytical pure chemical reagent, content be greater than 99.0%, Shenyang City's reagent three factory's lot numbers 910404.
Potassium pyrophosphate (anhydrous) Na
4P
2O
71.68 gram
Analytical pure chemical reagent, content be greater than 99.0%, Shenyang City's reagent three factory's lot numbers 910502
5 milliliters of distilled water
Citric acid a little
Toothpaste matrix increases the weight of to 60 grams
Both prevented the tartar formulation of toothpaste: tetrasodium pyrophosphate 0.5～1.0%; Potassium pyrophosphate 2～3.5%; Distilled water 7～10%; Citric acid 7%; Toothpaste matrix 83.5%～78.5%
Preparing process:
The pyrophosphate that takes by weighing recipe quantity grinds and is superfine powder; 5 milliliters of adding distil waters grind and wiped 10 minutes; Add the blank toothpaste matrix of equivalent and grind wiping 20 minutes; Add after a little citric acid powder grinds evenly, equivalent increases progressively and adds toothpaste matrix and grind evenly, irritate bag, seal promptly one by one.The sample of prevention tartar toothpaste.Amount increases progressively the adding toothpaste matrix and grinds evenly, irritates bag, seals promptly.The sample of prevention tartar toothpaste.
The quality of prevention tartar toothpaste is checked and approved with reference to " State Standard of the People's Republic of China " GB8372-87 and the two-shift system of " Chinese Pharmacopoeia " nineteen ninety-five version and is ordered.
Toothpaste is shaped as evenly, fine and smooth, the normal body of paste of color and luster.PH value is: 5～10, take out after freezing 8 hours at-8 ℃ of refrigerators, and return to room temperature and uncap, mastic should not overflow the mouth of pipe, and mastic is all squeezed on blank sheet of paper, and it is normal not separate water outlet, fragrance, color and luster; Total number of bacteria is not more than 500/gram; Lead tolerance is not more than 25PPM; Arsenic content is not more than 5PPM.
The sense palace requires: mastic should be evenly, fine and smooth, cleaning, color and luster are normal.
Effectiveness, safety and the poison of prevention tartar toothpaste paid the experiment and the discussion of effect.
The lithodialysis test:
Purpose is to investigate chemicals to the tartar dissolution.Method be with tartar from the tooth of living clean with a pointed instrument, pulverize, be dried to constant weight, precision is weighed, to claim the tartar after fixed after three months, to filter, for several times with distilled water wash with glass funnel with the solution soaking that contains chemicals, the accurate title, decide after drying, the constant weight, calculates the amount that subtracts mistake of tartar.Conclusion is that the mixing material immersion tartar of tetrasodium pyrophosphate 0.765% and potassium pyrophosphate 3.018% has excellent solute effect.
Formula test:
Purpose is to propose the dissolution of three kinds of prescription investigations to tartar.Soak tartar after three months with three kinds of prescription B, C, D proposing, calculate tartar and soak the weight that subtracts mistake after three months.
Prescription:
B: contain 0.50% tetrasodium pyrophosphate; 3.50% potassium pyrophosphate
C: contain 0.80% tetrasodium pyrophosphate; 2.80% potassium pyrophosphate
D: contain 1.00% tetrasodium pyrophosphate; 2.00% potassium pyrophosphate
Material is the same
Result: through B, C, three kinds of solution soaking tartar of D after three months; The weight that tartar subtracts mistake is respectively: 70.5%; 71.5%; 73.5%, prove and can dissolve tartar.
Find by experimental observation: none routine soak produces and goes mouldy or denaturalization phenomenon in trimestral immersion process, and the former tartar color after soaking is translated yellow pitchy and become ivory buff.
Clinical experimental study adopts 60 young student of severe tartar volunteer, male 38 people, women 22 people, 44 people of Han nationality, 16 people of the Uygur nationality.Require the observed person sooner or later respectively to brush teeth once every day, every month with 2 gram Tooth paste brushes three minutes.It is P＜0.02 that statistical analysis, result are used in the experiment back, and two groups of tartar difference differences are described, used medicated toothpaste has effect to suppressing tartar.
The animal of toxicological experiment research is 20 of the Xiao Bai that provided by Xinjiang Medical College animal housing, 12 of the healthy adult rabbit that provides by Xinjiang animal housing of pharmaceutical factory, test shows no overt toxicity reaction, safe and reliable to the rabbit eye mucosa, no obvious irritation, toothpaste are brushed teeth as cleaning agent for mouth cavity, and to use be safe and reliable.
Chemicals is tested the influence of normal dental calcium content:
After normal tooth enamel was ground into powder, calcium content was 95.6% after measured.
Measure the influence of anti-tartar No. 2 (containing 0.80% tetrasodium pyrophosphate, 2.80% potassium pyrophosphate) to normal dental calcium.Assay method is 4 of enamels getting no tartar tooth, soaks twice No. 2 every days with anti-tartar, each 3 minutes, and soak after three months with the distilled water cleaning, drying, pulverize the back constant weight, accurately claim fixed 5 parts, measure the content of calcium.
Conclusion: the dentifrice after 5 parts after measured (every part average measurement 3 times) soaks, its average calcium content is 83.4%, normal tooth is after soaking with No. 2 imitations of anti-tartar clinical application mode, and calcium content descends 12.2% approximately in stripped tooth experiment, and pyrophosphate can make the tooth calcium content descend.But in people's biological tissue, do not cause enamel decalcification because of normal physiological regulation.Sialoprotein matter among the human saliva can promote the maturation and the remineralization of damaged enamel.
The oral cavity tartar illness that has a large capacity and a wide range is difficult to accomplish that everybody regularly arrives Medical-Dental Division and mainly rejects by mechanical means, cause gingivitis, periodontitis prevalence to increase, and even it is high to lose the tooth rate.The toothpaste of prevention tartar of the present invention, be in the ordinary toothpaste mastic, to add the medicine that can prevent tartar to form, the method for brushing teeth that adopts everybody to accomplish, by the secondary of brushing teeth every day, each 3 minutes, form with the prevention tartar, guarantee oral health, prevention tartar toothpaste of the present invention has social benefit and economic benefit.
Claims (2)
1, a kind of prevention tartar toothpaste adds chemicals and forms in the ordinary toothpaste body, it is characterized in that preventing tartar formulation of toothpaste, dosage is tetrasodium pyrophosphate 0.5～1.0%; Potassium pyrophosphate 2～3.5%; Distilled water 7～10%; Citric acid 7%; Lotion of toothpaste 83.5%～78.5%.
2, the described prevention tartar of claim 1 toothpaste, it is characterized in that described potassium pyrophosphate, tetrasodium pyrophosphate adopt the pure level of chemical analysis product to grind to form superfine powder, adding distil water grinds, and increases progressively that principle adds progressively that toothpaste matrix grinds evenly, fill, seals by equivalent again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98109075 CN1237411A (en) | 1998-06-02 | 1998-06-02 | Toothpaste for preventing dental calculus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98109075 CN1237411A (en) | 1998-06-02 | 1998-06-02 | Toothpaste for preventing dental calculus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1237411A true CN1237411A (en) | 1999-12-08 |
Family
ID=5219876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 98109075 Pending CN1237411A (en) | 1998-06-02 | 1998-06-02 | Toothpaste for preventing dental calculus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1237411A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530152B (en) * | 2009-04-21 | 2011-04-20 | 辽宁天淇食品集团有限公司 | Functional health-care ice cream |
| CN102369013A (en) * | 2009-04-02 | 2012-03-07 | 高露洁-棕榄公司 | Oral care compositions comprising tetrapotassium pyrophosphate |
-
1998
- 1998-06-02 CN CN 98109075 patent/CN1237411A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102369013A (en) * | 2009-04-02 | 2012-03-07 | 高露洁-棕榄公司 | Oral care compositions comprising tetrapotassium pyrophosphate |
| CN101530152B (en) * | 2009-04-21 | 2011-04-20 | 辽宁天淇食品集团有限公司 | Functional health-care ice cream |
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