CN1235519A - Chewing gum composition and production thereof - Google Patents
Chewing gum composition and production thereof Download PDFInfo
- Publication number
- CN1235519A CN1235519A CN97199312A CN97199312A CN1235519A CN 1235519 A CN1235519 A CN 1235519A CN 97199312 A CN97199312 A CN 97199312A CN 97199312 A CN97199312 A CN 97199312A CN 1235519 A CN1235519 A CN 1235519A
- Authority
- CN
- China
- Prior art keywords
- chewing gum
- bone
- calcium
- hydroxyapatite
- bone mineral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/064—Chewing gum characterised by the composition containing organic or inorganic compounds containing inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
Abstract
A chewing gum composition which comprises bone minerals, tricalcium phosphate and hydroxyapatite in a gum base, which is effective in enhancing bone strength, strenghtening tooth substance, whitening teeth and so on; and a process for the production thereof.
Description
The present invention relates to a kind of composition and manufacture method thereof of chewing gum.Particularly relate to a kind of when safety is replenished the calcium, to the composition and the manufacture method thereof of more efficiently chewing gums such as the reinforcement of the whitening of tooth, dentine, prevention halitosis.
Many replenish calcium nutrition health foods, chewing gum were once sold in existing market.
In the nutritional health food of existing these usefulness of replenishing the calcium, as the calcium source, the various organic calcium salts of inorganic calcium salts such as calcium carbonate and calcium citrate, calcium malate, calcium lactate etc. have been used.
As inorganic calcium salt, it is more that calcium carbonate is used, but after in a single day it be dissolved in hydrochloric acid in gastric juice, just produce alkaline quick lime together with carbonic acid gas.Though this quick lime can be very fast by in the hydrochloric acid in gastric juice and generate the salt of salinization calcium etc., as huge uptake, might neutralize endless, and excessively rise because of remaining quick lime causes the pH value in the stomach.Moreover, the organic calcium salt of calcium citrate, calcium malate, calcium lactate etc., absorbability is no doubt good, but the calcium content of Unit Weight is less.
In addition, used in the past above-mentioned substance all only is the material that calcium constituent replenishes separately.
On the other hand, constitute the inorganic constituents material of skeleton, tooth, constituted by the calcium phosphate compound that is referred to as apatite (osteolith) that calcium, phosphorus and water form.Therefore, in order to strengthen dentine, to increase bone strength etc., compare with replenishing the calcium merely, replenish the material that contains calcium and phosphorus simultaneously and be considered to more reasonable.
And in modern society, because of the variation of habits and customs, people are to absorbing nourishment simply, and the demand that contains the functional food of multiple nutritional components has again increased.
In this case, people's expectation is developed strengthening the multi-functional nutritional health food that dentine, increase bone strength etc. have effect.
Main purpose of the present invention is, overcomes the existing defective that exists, and a kind of chewing gum compositions of new structure is provided, and makes it can be when safety is replenished the calcium, again to strengthening dentine, increasing the food compositions that each side such as bone strength has effect.
Another object of the present invention is to, a kind of manufacture method of chewing gum compositions is provided.
The present inventor makes any one above composition that can contain in the chewing gum base in bone mineral, tricalcium phosphate, the hydroxyapatite through research repeatedly, and above-mentioned problem is solved, and finishes the present invention in view of the above.
The objective of the invention is to realize by following technical scheme.According to chewing gum compositions and manufacture method thereof that the present invention proposes, it is in chewing gum base, contains the chewing gum compositions that bone mineral, tricalcium phosphate and/or hydroxyapatite are feature.
In addition, in (1) chewing gum base manufacturing process and (2) chewing gum base, add adding ingredient and carry out on the processes for producing chewing gums of contour machining procedure, the present invention contains the manufacture method that bone mineral, tricalcium phosphate and/or hydroxyapatite are the chewing gum compositions of feature also relevant in chewing gum base
The present invention compared with prior art has tangible advantage and good effect.By above technical scheme as can be known, chewing gum compositions of the present invention not only can replenish calcium, make again calcification relevant and control blood platelet become possibility simultaneously with strengthening dentine, but prevention of osteoporosis promotes the growth of tooth and jawbone thus, and reinforcement dentine, tooth-whitening are also had effect.
Below describe enforcement optimum state of the present invention in detail.
Chewing gum component of the present invention is meant in chewing gum base, contains bone mineral, tricalcium phosphate and/or hydroxyapatite.
At this so-called bone mineral, be meant the vertebrate bone of ox, pig, chicken, various fish etc., after chemical treatment, heat treatment, remove organic substance, only obtain the part of the inorganic substances of essence.In general, after the bone drying of animal, fish etc. removed moisture and make coccoid, the material that is referred to as osteolith that contains phosphorus, calcium, minor metallic element accounted for 70% weight, accounted for 30% weight based on the organic substance in gelatine source.So-called bone mineral is meant that the organic substance the latter is removed from this coccoid, only extracts the part of the osteolith that contains minor metallic element.In these bone minerals, because contain the metals useful such as micro-magnesium, strontium, iron, manganese, zinc, so more satisfactory to human body.
For obtaining the bone of the used animal of bone mineral, though do not have particular determination, from the difficulty handled, contain the isotropism of calcium and phosphorus composition, from the possibility of stable supplying, fish are ideal.In fish, can list as stripped tuna, tuna, fish, Hake etc., this wherein, as food additives a large amount of produce, foreign body is few, the bone (cod bone) of the uniform Hake of composition (Cadiformes), tuna, stripped tuna are then better.In Hake, specifically also can list true cod, walleye pollack, end cod, poor cod fish etc.The ratio of components of calcium and phosphorus (Ca/P) is 1.67 in the cod bone, exactly likes the ratio of components of people's bone.
As an example of bone mineral manufacture method, for example the bone mineral with Hake can be obtained by following method.
Promptly Hake is heated, removes flesh of fish part, use pressure cooker after hot water treatment under high temperature (about 120 ℃), the high pressure (2 below the atmospheric pressure) fish-bone, the biochemistry of using protease to carry out protein resolution process etc. is handled, further heat treated is removed organic matter again, extracts the white osteolith that contains minor metallic element.The fish-bone of cod bone etc. is handled so more easily carry out biochemistry because of more tiny.And fat is also less, just can remove organic substance fully so can carry out heat treated at the low temperature below 800 ℃, and is also less because of the situation of incomplete combustion grizzle, can obtain the osteolith of high whiteness.This osteolith foreign body is few, and as food additives, can classify is fired into fishbone dust, bone calcium powder etc.
Another that the present invention comprised must composition be more than any one of tricalcium phosphate [Ca3 (PO4) 2], hydroxyapatite [Ca10 (PO4) 6 (OH) 2].The ratio of the calcium of these materials and the phosphorus all bone with the people is identical or close, so promptly safety is easy to human body acceptance again.These tricalcium phosphates, hydroxyapatite can be made by well-known method is synthetic.Simultaneously, in the present invention, compare, more wish amorphous material with tricalcium phosphate, hydroxylapatite crystal material.Generally saying so-called amorphous material, is the length (size of crystallization that regular atom 3 dimensions are arranged.According to ceramics, be equivalent to the size of primary particle) in the address of the following material of 200nm (0.2 μ m).Though knowing the calcium phosphate of hydroxyapatite etc., people can adsorb the protein of blood platelet etc., fat, sugar etc., particularly surface coefficient is big, not only can or remove the blood platelet absorption that is related to tooth whitening, and also very effective to the calcification again that is related to the dentine reinforcement.The powder diameter of the used hydroxyapatite of the present invention, tricalcium phosphate is the following amorphous substance of 1 μ m, and surface coefficient is comparatively desirable in the 10-100 scope, when disperseing to add, wishes that 2 particle diameters are the particulates below 50 μ m.
And, osteolith (bone mineral), to some extent difference different with the composition of hydroxyapatite.Pure hydroxyapatite is to represent with Ca10 (PO4) 6 (OH) 2.And osteolith is meant the carbonated water acid apatite (mineral name podolite) after the phosphate of pure hydroxyapatite has partly been replaced the carbonyldioxy of 1-3%, and, calcium content bigger than pure hydroxyapatite solubility lacks.Corresponding insufficient section is replaced by atoms such as hydrogen, magnesium, sodium, and being referred to as hypocalcia apatite (Calcium-defecientapatite) has again, and the part of hydroxyl is replaced by carbonyldioxy, the plain atom of salt, fluorine atom.Hydroxyl is referred to as fluor-apatite, is referred to as fluor-apatite by what fluorine atom was replaced by what the plain atom of salt was replaced entirely.In " bone mineral " of the present invention lining, also comprise the material of partly or entirely being replaced of these hydroxyls by other atom.
In the present invention, the total use level of bone mineral, tricalcium phosphate and/or hydroxyapatite accounts for 1-20% weight in chewing gum component better, and even more ideal is the weight that accounts for 4-10%.Use level is very few, be difficult to embody positive effect of the present invention, and use level is too much, can cause the excessive drawback of aforesaid calcium amount again, and mouthfeel descends.Bone mineral is arranged again: the match ratio (weight ratio) of (tricalcium phosphate and/or hydroxyapatite) preferably is controlled at 10: 1-1: 10 scope, even more ideal is 7: 3-3: 7.But, only in the calcium phosphate of tricalcium phosphate, hydroxyapatite etc., be not contain the mineral matter that strengthens bone strength.Bone mineral is because of the kind difference of animal, fish, and its foreign body, whiteness are also different, thereby when making an addition to food, outward appearance etc. is also brought many influences.
Chewing gum a slice heavily is 3g, if the total amount of the bone mineral, tricalcium phosphate and/or the hydroxyapatite that add is 20%, then its weight should be 0.60g (=600mg).And the calcium in bone mineral, tricalcium phosphate and/or the hydroxyapatite accounts for 40%, then should contain the calcium of 240mg in the total amount of 600mg.Being adsorbed more than 50% in the base-material that remains in chewing gum in this calcium is so enter intraoral usually below 50%.Thereby ingestible calcium amount is below the 120mg from a slice chewing gum, this be equivalent to be grown up one day must calcium amount 600-800mg 1/5-1/7.As absorb excessive calcium, hydrochloric acid in gastric juice is excessively neutralized, and cause pathologic calculus such as urethral calculus, so the calcium amount of being absorbed from a slice chewing gum can be thought safe and an amount of.
Simultaneously, aspect chewing gum component of the present invention, in the scope of not losing effect of the present invention, usually can be in chewing gum compositions, any adding ingredient.For example add a little vitamin Cs, vitamin D, dextranase etc., can more improve effect of the present invention.
As mentioned above, by chewing chewing gum of the present invention, can moderately replenish calcium and mineral matter, be related to the blood platelet control of tooth whitening and the calcification again of reinforcement dentine also becomes possibility more in addition simultaneously.In other words, chewing gum of the present invention, but prevention of osteoporosis not only promote the growth of tooth, jawbone, but also Pear Power and strengthen the compound action of tooth.
For another example, drinking water etc. contain under the situation of calcium, just absorb excessive calcium at short notice because of chewing, and cause hydrochloric acid in gastric juice sharply to neutralize, and make the burden of stomach increase.Moreover, absorb excessive calcium, also may cause illnesss such as gall stone, urethral calculus, in contrast to this,, take time and saliva is little by little sent in the stomach as eating chewing gum, dangerous little and safe and effective.
The manufacture method of chewing gum compositions of the present invention comprises chewing gum base manufacturing process and adds adding ingredient and carry out the operation of processing and forming at chewing gum base.
In chewing gum base manufacturing process, at first back, dehydration are washed, heated to the natural resin that is generally used for chewing gum base with kneader (mixer).Heating-up temperature was dewatered 10-15 hour about 110-130 ℃.Then, natural resin and needed chewing gum base after the dehydration are fed into kneader (mixer) lining of heating in proper order, be incubateds about 110-130 ℃, individual hour of dehydration 3-5, mixed dissolution is until evenly.The present invention contains bone mineral, tricalcium phosphate and/or hydroxyapatite in this kind chewing gum base.
Next, the above-mentioned chewing gum base that obtains is carried out processing and forming.With mixer chewing gum base and other any adding ingredients are mixed earlier.The for example interpolation of carbohydrate adds 1/2 of aequum usually, through about 10 minutes mixing after, add remaining carbohydrate and softening agent.These mixtures were stirred 30-40 minute, add spices at last, stir after 1-2 minute and take out, the final temperature of chewing gum is best at 40-60 ℃.This chewing gum is dropped into press, just can suppress 20-40mm thick, widely be the ribbon of 400-470mm, then on one side with the pulverized sugar full coat in obverse and reverse, one side be pressed into the thin slice that thickness is 1.5-2.5mm by calendar rollers.Block according to required size again, pack after the maturation, just can be used as the composition of chewing gum.
Below, further set forth the present invention according to example, but the present invention is not limited thereto.Embodiment
Made the chewing gum of following table 1 composition (weight %) according to a conventional method.The average grain diameter of employed tricalcium phosphate, hydroxyapatite (primary particle size) is about 0.2 μ m.
Table 1
| Test portion No. | The cod bone mineral | The ox bone mineral matter | Tricalcium phosphate | Hydroxyapatite | Vitamin D | Dextranase | Chewing gum base |
| ????1 | ????-- | ??-- | ????-- | ??-- | ??-- | ??-- | ????100 |
| ????2 | ????1 | ??-- | ????-- | ??-- | ??-- | ??-- | ????99 |
| ????3 | ????4 | ??-- | ????-- | ??-- | ??-- | ??-- | ????96 |
| ????4 | ????10 | ??-- | ????-- | ??-- | ??-- | ??-- | ????90 |
| ????5 | ????20 | ??-- | ????-- | ??-- | ??-- | ??-- | ????80 |
| ????6 | ????1 | ??-- | ????1 | ??-- | ??-- | ??-- | ????98 |
| ????7 | ????4 | ??-- | ????4 | ??-- | ??-- | ??-- | ????92 |
| ????8 | ????10 | ??-- | ????10 | ??-- | ??-- | ??-- | ????80 |
| ????9 | ????4 | ??-- | ????-- | ??4 | ??-- | ??-- | ????92 |
| ????10 | ????-- | ??4 | ????4 | ??-- | ??-- | ??-- | ????92 |
| ????11 | ????4 | ??-- | ????4 | ??-- | ??1 | ??-- | ????91 |
| ????12 | ????4 | ??-- | ????-- | ??4 | ??-- | ??1 | ????91 |
Embodiment 1
The whiteness that records cod bone mineral, ox bone mineral matter, tricalcium phosphate, hydroxyapatite with colorimeter is respectively 96.0,90.0,97.0,97.5.Wherein the whiteness of hydroxyapatite is the highest, and the ox bone mineral matter is 90.0, the minimum gray of whiteness.The whiteness of cod bone mineral is 96.0, and numerical value is quite high.
Embodiment 2
With the body weight in 5 weeks of birth is that 60 of the big white mouse that the female Wistar about 160 ± 10g is are divided into 12 groups, 5 every group.
To these 12 groups of big white mouse every days twice, totally 5 weeks respectively per os throw in each 1g of powder of test portion shown in the tables 1.After the input,, use the three-point bending strength testing machine, measured the load (MP, MPa) when beginning with the discriminative fracture of thigh bone strength to all big white mouse.Bone reinforcement rate is 100 to convert and calculated with control (test portion 1), and the result is as shown in table 2
Table 2
| Group | Fracture beginning load | Bone reinforcement rate |
| 1 group of test portion | ????3.9MP | ????0.0％ |
| 2 groups of test portions | ????4.0 | ????2.6 |
| 3 groups of test portions | ????4.2 | ????7.7 |
| 4 groups of test portions | ????4.3 | ????10.3 |
| 5 groups of test portions | ????4.3 | ????10.3 |
| 6 groups of test portions | ????4.1 | ????5.1 |
| 7 groups of test portions | ????4.5 | ????15.4 |
| 8 groups of test portions | ????4.6 | ????17.9 |
| 9 groups of test portions | ????4.5 | ????15.4 |
| 10 groups of test portions | ????4.4 | ????12.8 |
| 11 groups of test portions | ????4.6 | ????17.9 |
| 12 groups of test portions | ????4.5 | ????15.4 |
As shown in Table 2, compare with test portion 1 (control), the powder that will contain calcium sources such as cod bone mineral throw with big white mouse after, all increased the degree that bone is strengthened.Further add tricalcium phosphate and hydroxyapatite to the cod bone mineral again, for example shown in test portion 3 and test portion 7, bone reinforcement rate increases to 15.4% from 7.7%.Particularly test portion 5 and test portion 8 are to have added 20% the cod bone mineral and the mixture of tricalcium phosphate, and its test portion with the cod bone mineral that only adds 20% weight compared, and have obviously increased bone reinforcement rate as can be known, also can see the effect of some vitamin Ds.
Embodiment 3
To be grown up 10 and be divided into 2 groups by 5 every group, give the chewing gum with test portion 3 for one group, another group is given the chewing gum with test portion 7, eats 3-5 sheet (every 3g) respectively every day, chewed 5-15 minute at every turn, and then tested the stripping quantity and the hematoblastic adhesion amount of intraoral calcareous grade.
That is to say and adopt 800 ℃-1000 ℃ temperature that the chewing gum of chewing is heated, to remove remnant (residual amount) behind the organic matter as bone mineral and calcium phosphate (tricalcium phosphate, hydroxyapatite), measure each weight, calculate stripping quantity to materials such as intraoral calcium from the minimizing of its weight.Its result, it is the 5-50% of weight that the weight that causes because of the stripping of materials such as calcium reduces.In test portion 7 these groups, contain 8% cod bone mineral and tricalcium phosphate in the weight by 1 3g, the cod bone mineral and the tricalcium phosphate that contain 240mg as can be known in 1 chewing gum, wherein calcium accounts for 40% of weight, be 96mg, from the weight of stripping 5-50% in the oral cavity, every chewing gum can make the materials such as calcium that absorb 4.8-48mg in the body again.If the required calcium amount of per day for adults is 800mg, then uptake is the 0.6-6% of aequum, and 3-5 sheet chewing gum is the degree of 1.8-30% just, this is a suitable intake, in addition, even eat considerable chewing gum, do not worry causing the calcium pickup amount excessive yet.
The method of also dividing 5 stages that the blood platelet adhesive rate before and after the chew gum is gargled with dimethyl diaminophenazine chloride (red colouring liquid) is in addition measured, and compares with test portion 3 as can be known from its result, and the blood platelet adhesive rate of test portion 7 will lack 1 grade to 2 grades.
Adopt the assay method identical, record the blood platelet adhesive rate minimizing aspect of test portion 12 chewing gums, also effectively than test portion 7 with said method.
Claims (7)
1. a chewing gum compositions is characterized in that it contains bone mineral, tricalcium phosphate and/or hydroxyapatite in chewing gum base.
2. chewing gum compositions according to claim 1 is characterized in that described bone mineral is by obtaining in the fish-bone.
3. chewing gum compositions according to claim 2 is characterized in that described fish-bone is to choose any one kind of them in the middle of cod bone, stripped tuna bone, tuna bone.
4. chewing gum compositions according to claim 3 is characterized in that described fish-bone is the cod bone.
5. chewing gum compositions according to claim 1 is characterized in that containing bone mineral and the calcium phosphate and/or the hydroxy-apatite of 1-20% weight in the chewing gum compositions total amount.
6. chewing gum compositions according to claim 1, it is characterized in that described bone mineral and tricalcium phosphate and/or hydroxyapatite are by 10: 1-1: 10 (weight ratios) cooperate.
7. the manufacture method of a chewing gum compositions, be included in chewing gum base in (I) chewing gum manufacturing process with (II) and add adding ingredient and carry out processing and forming, it is characterized in that in chewing gum base, to contain bone mineral and tricalcium phosphate and/or hydroxyapatite.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30588096 | 1996-10-31 | ||
| JP305880/96 | 1996-10-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1235519A true CN1235519A (en) | 1999-11-17 |
| CN1086917C CN1086917C (en) | 2002-07-03 |
Family
ID=17950443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97199312A Expired - Fee Related CN1086917C (en) | 1996-10-31 | 1997-10-31 | Chewing gum composition and production thereof |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP3911526B2 (en) |
| CN (1) | CN1086917C (en) |
| AU (1) | AU4726497A (en) |
| WO (1) | WO1998018339A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103988970A (en) * | 2013-02-14 | 2014-08-20 | 桑德罗·莱山 | mineral nutrients |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6491540B1 (en) | 1999-09-20 | 2002-12-10 | Jack Barreca | Center-filled supplement gum |
| US9253991B2 (en) | 1999-09-20 | 2016-02-09 | Jack Barreca | Chewing gum with B vitamins |
| US9387168B2 (en) | 1999-09-20 | 2016-07-12 | Jack Barreca | Chewing gum with tomatidine |
| US6471945B2 (en) | 2000-03-10 | 2002-10-29 | Warner-Lambert Company | Stain removing chewing gum and confectionery compositions, and methods of making and using the same |
| US6485739B2 (en) | 2000-03-10 | 2002-11-26 | Warner-Lambert Company | Stain removing chewing gum and confectionery compositions, and methods of making and using the same |
| US9271904B2 (en) | 2003-11-21 | 2016-03-01 | Intercontinental Great Brands Llc | Controlled release oral delivery systems |
| US7727565B2 (en) | 2004-08-25 | 2010-06-01 | Cadbury Adams Usa Llc | Liquid-filled chewing gum composition |
| US20070166362A1 (en) * | 2004-10-07 | 2007-07-19 | Shuji Sakuma | Transdermal and transmucosal preparations |
| US8293274B2 (en) | 2005-04-06 | 2012-10-23 | Kabushiki Kaisha Sangi | Intestinal absorptive anti-tumor agent |
| RU2421207C2 (en) | 2006-04-05 | 2011-06-20 | КЭДБЕРИ АДАМС ЮЭсЭй ЛЛС | Oral composition for improving subsurface remineralisation of denal enamel in mammal |
| US20070237804A1 (en) | 2006-04-05 | 2007-10-11 | Cadbury Adams Usa, Llc. | Impact of calcium phosphate complex on dental caries |
| US8590116B2 (en) | 2009-12-24 | 2013-11-26 | Jeffery Dahl | Loop rope assembly |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57125676A (en) * | 1981-01-29 | 1982-08-05 | Hideki Sugioka | Preparation of powdered calcium compound used as a food additive |
| US4867989A (en) * | 1986-09-09 | 1989-09-19 | Warner-Lambert Company | Chewing gum mineral supplement |
| JPH0695888B2 (en) * | 1989-10-18 | 1994-11-30 | 株式会社サンギ | Chewing gum for calcium supplement |
| JPH04121166A (en) * | 1990-09-10 | 1992-04-22 | San Beesu Food Kk | Preparation of edible bone meal |
| JPH05252904A (en) * | 1992-03-12 | 1993-10-05 | Yamanouchi Pharmaceut Co Ltd | Granule of baked bone meal and its production |
| JPH05276873A (en) * | 1992-04-02 | 1993-10-26 | Fujimi Green Eng Kk | Dentifrice gum |
-
1997
- 1997-10-31 JP JP52030298A patent/JP3911526B2/en not_active Expired - Fee Related
- 1997-10-31 AU AU47264/97A patent/AU4726497A/en not_active Abandoned
- 1997-10-31 CN CN97199312A patent/CN1086917C/en not_active Expired - Fee Related
- 1997-10-31 WO PCT/JP1997/003973 patent/WO1998018339A1/en active Application Filing
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103988970A (en) * | 2013-02-14 | 2014-08-20 | 桑德罗·莱山 | mineral nutrients |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1086917C (en) | 2002-07-03 |
| AU4726497A (en) | 1998-05-22 |
| JP3911526B2 (en) | 2007-05-09 |
| WO1998018339A1 (en) | 1998-05-07 |
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