CN1224444A - Antimicrobial cleaning compositions contg. aromatic alcohols or phenols - Google Patents
Antimicrobial cleaning compositions contg. aromatic alcohols or phenols Download PDFInfo
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- CN1224444A CN1224444A CN 97196126 CN97196126A CN1224444A CN 1224444 A CN1224444 A CN 1224444A CN 97196126 CN97196126 CN 97196126 CN 97196126 A CN97196126 A CN 97196126A CN 1224444 A CN1224444 A CN 1224444A
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Abstract
The invention relates to the use of an optionally substituted aromatic alcohols or phenols, other than phenol per se, of the general formula: HO.R1.Aryl(R2)n wherein R1 is absent or is C1-C6 alkyl, alkenyl or alkoxy, R2 is absent or one or more ring substituents selected from C1-C6 alkyl, alkenyl or alkoxy, and n is 0-5, as a biocidal activity improving additive in a non-abrasive cleaning composition of pH below 6 or above 9 which comprises 0.1-30 wt.% of an ethoxylated alkanol nonionic surfactant with an HLB of 9-14. The invention also relates to compositions comprising 0.15-15 wt.% of the phenol or alcohol and to a method of cleaning a surface which involves the step of treating the surface with such a composition.
Description
Invention field
The present invention relates to contain the antimicrobial cleaning compositions of tensio-active agent and sunitizing, said tensio-active agent improve aspect sunitizing active purposes and with the method on said compositions-treated surface.
Background of invention
Hard-surface cleaning composition usually contains one or more tensio-active agents and one or more optional sunitizings.
Usually, used tensio-active agent is selected from negatively charged ion, nonionic, amphoteric and cats product in such cleaning combination.Nonionogenic tenside is in daily use, because they have good removal performance and their foam performance to be easy to control for grease.In the middle of these tensio-active agents, nonionogenic tenside shows very low biocidal activity, and some negatively charged ion, positively charged ion and amphoterics show biocidal activity under specific for example pH and concentration conditions.Usually, except a small amount of significantly exception, the biocidal activity of tensio-active agent is very low, also sunitizing separately is added in the composition usually.
General sunitizing comprises strong acid, alkali, phenol and oxygenant for example peracid and mistake halate.In the middle of this, its exemplary is a perchlorate, and they generally are highly active materials, shows the activity of storage time, toxicity, corrodibility and pungency aspect that one or more are short.Usually, the required amount to these active ingredients is bigger in prescription.Other low chemically active sunitizing for example 2,4,4 '-three chloro-2 '-hydroxy diphenyl ether (can with trade(brand)name IRGASANDP300[RTM] bought) are effectively at low concentration, but are more expensive than simple material, and may be specific for their active spectrogram.A lot of organic acids comprise that phenylformic acid, Whitfield's ointment and Sorbic Acid are known as sanitas in makeup and some food, but, when using with identical amount, these sanitass usually show lower biocidal activity than above-mentioned chemically reactive sunitizing.
The wearing and tearing hard-surface cleaning composition that cleans grease and particulate fouling that provides that contains terpenes or benzylalcohol and nonionogenic tenside is provided EP 0126545.The preferred pH of disclosed said composition is 8-11.
WO 89/12673 discloses miticide composition, and it comprises benzylalcohol (as miticide) and nonionogenic tenside.The pH of this prescription is 7.5-12.5 when pure state preferably, is 3.0-10.0 when dilution.Employed these tensio-active agents are specific, and extremely low surface tension is arranged after the mixing, and they comprise phenol ethoxylate or amphoterics.In the property enumerated prescription, comprise cats product, so that the antibiont activity to be provided.
WO 93/11211 discloses and used a spot of amphyl and the ethylating fatty alcohol derivative of oxygen in alkaline hard-surface cleaning composition.This amphyl maximum be 0.03% (weight).
WO 94/14942 discloses neutral cleaning combination, and it contains the mixture of the nonionogenic tenside of the alcohol that comprises benzylalcohol and ethoxylation.The pH of the regulation of these compositions is 9-5.
US 4311618 discloses cleaning agent, and the aromatic alcohol of nonionogenic tenside that its HLB value that can contain wide range is 5-20 and optional replacement and/or phenol are as sunitizing.
Known natural phenol comprises many biocidal compounds, comprise Thymol and Carvacrol J.Food Prot (1995) 58 (10) 1147-9 such as () Daouk, it shows that to antifungal, yeast and bacterium be effectively (J Essent.Oil.Res. (1995) 7 (3) 299-303).
In hard surface cleaning, need disinfect surfaces usually.' sterilizing agent ' can be understood as a kind of like this sunitizing, and when using with the amount of about 0.5% (weight), its demonstration has 100,000 times or bigger minimizing to the microbial numbers that can grow in the specific nutrient solution.It usually is called " log5 kill ratio ".
Have been found that some tensio-active agents make some sunitizing more effective.The pure and mild organic acid that DE 3619375 (Henkel) discloses alkyl polyglycoside (APG) tensio-active agent and lower molecular weight demonstrates synergy aspect hygiology, and discloses and contain APG and organic acid composition.Under strongly-acid pH, use these compositions, usually be lower than pH3.
It is believed that itself relatively shows the effect of reduction the mixture of other tensio-active agent/biocide and biocide.(Porter 1990 at ' tensio-active agent ', Elsevier) in, it is introduced, though the nonionogenic tenside of lower concentration (subcritical micellar concentration), when they have the biocidal performance, quaternary compound is had synergy, but usually nonionogenic tenside is inhibited to biocides.A kind of theory that this has been proposed is that this biocides is adsorbed onto in the micella of this tensio-active agent, therefore accessible effect is reduced.Have been noted that similar result (above-mentioned, the 107th page, 4.5.4 part) for phenol, it is believed that the biology that destroys phenol possibly than higher nonionogenic tenside concentration kills activity.Be that the ratio that is in excess in nonionogenic tenside just has synergism only, the ratio of all other is then shown antagonistic action phenol.
The invention summary
We after measured, about anti-microbial effect, aromatic alcohol or phenols, rather than phenol itself, and between the alkanol nonionogenic tenside of ethoxylation show the obvious synergistic effect, exceed the physiological pH scope.
Therefore, first aspect of the present invention provide a kind of antimicrobial, non-wearing and tearing, pH is higher than 9 or 5 or be lower than 5 composition, it comprises:
A) aromatic alcohol or the phenols of the optional replacement of the following general formula of 0.15-15% (weight), rather than phenol itself:
HO.R
1.Aryl(R
2)
n
Wherein: R
1Do not exist or R
1Be C1-C6 alkyl, thiazolinyl or alkoxyl group, R
2Do not exist or the ring substituents of the one or more C1-C6 of being selected from alkyl, alkenyl or alkoxyl group, n be 0-5 and
B) HLB of 0.1-30% (weight) is the alkanol nonionogenic tenside or the amine oxide of the ethoxylation of 9-14.
It is HO.R that second aspect of the present invention is to use general formula
1.Aryl (R
2)
nAromatic alcohol or the phenol rather than the phenol itself of optional replacement, as being 5 at pH or being lower than 5 or be higher than the additive that improves bio-killing activity in 9 the composition, R in the formula
1Do not exist or R
1Be C1-C6 alkyl, alkenyl or alkoxyl group, R
2Do not exist or the ring substituents of the one or more C1-C6 of being selected from alkyl, alkenyl or alkoxyl group, n is 0-5, said composition is less than wearing and tearing, and the HLB that includes 0.1-30% weight is the alkanol nonionogenic tenside of the ethoxylation of 9-14, or amine oxide.
The 3rd aspect of the present invention provides a kind of the cleaning and the method for disinfecting surface, it comprise with pH be higher than 9 or pH be 5 or be lower than the cleaning combination that 5 nothing weares and teares and handle said surface that said composition comprises:
A) aromatic alcohol or the phenol of the optional replacement of the following general formula of 0.15-15% (weight), rather than phenol itself:
HO.R
1.Aryl(R
2)
n
Wherein: R
1Do not exist or R
1Be C1-C6 alkyl, alkenyl or alkoxyl group, R
2Do not exist or the ring substituents of the one or more C1-C6 of being selected from alkyl, alkenyl or alkoxyl group, n be 0-5 and
B) HLB of 0.1-30% (weight) is the alkanol nonionogenic tenside or the amine oxide of the ethoxylation of 9-14.
As discussed above, known that HLB is that the oxyalkylated pure tensio-active agent of 9-14 is the bacterial growth inhibitor, but weak Biocidal effect has only been arranged under the pH of representative formula.In the presence of specific alcohol or phenol, the synergy of itself and specific nonionogenic tenside can provide effective cleaning and bio-killing activity.These performances meet the requirements in as the cleaning combination of health purpose, because to guaranteeing high sterilization and removing dirt so that the procreation again and the regrowth of prevention total plate count all are very important.Surprisingly obtain synergy with the vast scale nonionogenic tenside.Therefore, favourable aspect of the present invention be have with fairly simple and therefore cheaply preparation can obtain effective kill microorganisms and improve the key character of soil release performance.
Do not want to be subjected to the restriction of any theory of operation, it is believed that, when aromatic alcohol or phenol exist with tensio-active agent, form in the cytoplasmic membrane of bacterium in ' hole ', by this hole, the content of cell may exchange with surrounding environment.This confirms that by the institute of fluorescent probe Propidium iodide it is not that the cell with complete film absorbs.
The detailed description of invention
In order to can better understand the present invention, introduce the present invention below with reference to preferable feature and material.
Nonionogenic tenside
In composition of the present invention, there is nonionogenic tenside.These tensio-active agents are considered to participate in the synergy with aromatic alcohol or phenol, so that improve the sterilization characteristic of said composition.As noted above, suitable nonionogenic tenside is the alkanol and the amine oxide of ethoxylation.
The detergent-active compounds of the silane alcohol base of suitable ethoxylation can be described as the compound by the condensation production of ethylene oxide group and organic hydrophobic compound widely, with regard in nature, ethylene oxide group is hydrophilic, with regard in nature, organic hydrophobic compound can be aliphatic series or alkyl aromatic.Can adjust at an easy rate so that obtain the water-soluble the compound hydrophilic and equilibrium value that hydrophobic part is suitable that has with the hydrophilic radical of any special hydrophobic grouping condensation or the length of polyoxyethylene group.
Specific example is included in has the fatty alcohol of 8-22 carbon atom and the condensation product of oxyethane in the straight or branched configuration, for example have the cocounut oil ethylene oxide condensate of every mole of coco alcohol 3-10 moles of ethylene oxide.Alkylphenol ethoxylate does not belong within the scope of alkanol nonionogenic tenside of term ethoxylation, when its with in this manual the time.
The HLB value of the pure nonionogenic tenside of specific ethoxylation can be by calculating or measuring and determine.Preferred HLB is 10-17, more preferably 11-15.
The amount of the nonionic detergent active thing that in composition of the present invention, will use, for non-spissated product, 1-20% (weight) preferably, most preferably 3-10% is heavy, and typical embodiment concentration is about 7%.Usually will there be the nonionogenic tenside of 10-20% (weight) in spissated product, and will there be the nonionogenic tenside of 0.1-5% (weight) in the product that is applicable to the dilution of spraying.
Usually, this oxyalkylated nonionogenic tenside is C
8-C
14Chain length and per molecule have the alcohol of the ethoxylation of 4-10 oxyethyl group.
It is believed that the micelle-forming concentration of the nonionogenic tenside of this ethoxylation (CMC) preferably should be to be lower than 10
-3Mol, more preferably 10
-3-10
-5Mol.
In composition of the present invention, have been found that DOBANOL 91-8 (TM, ex.Shell), a kind of C of average 8 mole ethoxylates
9-C
11Alcohol is suitable nonionogenic tenside.The HLB of the calculating of this material is 13.7, and CMC is 7.8 * 10
-4Mol.
Amine oxide is suitable alternate tensio-active agent.Think that they are higher than at 2 o'clock at pH and are equivalent to nonionogenic tenside.Preferred amine oxide is the mono-alkyl dimethyl amine oxide, and preferably wherein alkyl is C
6-C
12Particularly preferred amine oxide is C
6-C
10Dimethyl oxidation amine.
The amount of the amine oxide detergent active thing that will use in composition of the present invention, for non-spissated product, preferably 1-20% is heavy, most preferably 3-10% weight.Usually will there be the heavy amine oxide surfactant of 10-20% in spissated product, and be applicable to that will there be the heavy amine oxide surfactant of 0.1-5% in the product of the dilution of spraying.
Aromatic alcohol or phenol
As mentioned above, composition of the present invention comprises the aromatic alcohol or the phenol of the optional replacement of following general formula, rather than phenol itself:
HO.R
1.Aryl(R
2)
n
Wherein: R
1Do not exist or R
1Be side chain or straight chain C 1-C6 alkyl, alkenyl or alkoxyl group, R
2Do not exist or one or more ring substituents and n that is selected from side chain or straight chain C 1-C6 alkyl, alkenyl or alkoxyl group is 0-5, condition is R when n=0
1Exist.
When n＞1, substituent R
2Need not be identical.Preferred R
2Base or group are selected from sec.-propyl, methyl, methoxyl group and 2-propenyl.Preferred at least one substituent R
2Be positioned at the 2-position or the 5-position of phenol.Composition more preferably of the present invention comprises the phenol of two-replacement, i.e. R
1Do not exist and n=2.Two-situation of the phenol that replaces under, two substituent R of Cun Zaiing preferably
2Group is different.
Particularly preferred composition comprises:
Thymol (5-methyl (2-isopropyl-phenol)),
The 2-phenylethyl alcohol,
Eugenol (2-methoxyl group-4[2-propenyl] phenol),
Isothymol (5-sec.-propyl 2-sylvan),
Benzyl alcohol,
Or their mixture.Thymol, Eugenol and isothymol are particularly preferred.
Particularly preferably be the log (P of aromatic alcohol or phenol
Oct) be greater than 1, P wherein
OctIt is the octanol/water partition ratio of this material.Preferred log (P
Oct) greater than 3, (P most preferably
Oct) be 3-4.Think that these materials with preferred partition ratio show especially effectively collaborative Biocidal performance.
Recognize that none is acid in this alcohol or the phenol, for example, scope of the present invention is not generalized to benzoic acid derivative, for example Whitfield's ointment and their derivative.
As mentioned above, the amount of aromatic alcohol or phenol is 0.15-15% (weight) in the composition.Preferably the amount of aromatic alcohol or phenol is 0.5-10% (weight) in the composition of pure state, preferred especially 1-5% (weight).Preferably the ratio of nonionogenic tenside and aromatic alcohol or phenol is 20: 1-1: 1, more preferably 10: 1-3: 1.
pH：
Composition of the present invention usually pH is lower than 12 greater than 2, i.e. 2-5 or 9-12.
Usually, the pH of said composition is 3.2-4.5, or 9.5-11.0.PH damages the vitreous enamel surface of some type less than 3.0 composition.PH will show the logarithm kill ratio that significantly reduces microorganism at the composition of physiological range (arriving less than 9 greater than 5).The composition of very high pH is prejudicial to the user.
A small amount of component and optional component
Composition of the present invention can contain other a spot of non-essential component, and these components can strengthen their cleaning performance, and keeps the physics and the chemical stability of product.
Preferably, said composition can contain detergent builders.Usually, preferably the 0.1-25% of composition weight is heavy for the washing assistant of use.Yellow soda ash, sodium bicarbonate and their mixture are suitable washing assistants.
Randomly, said composition can comprise one or more amphotericses, preferred trimethyl-glycine, or other tensio-active agent, for example alkyl-amino-glycinate.From cost, hypotoxicity and availability consideration widely, trimethyl-glycine is preferred.
Typical trimethyl-glycine is amide group-alkyl betaine in composition of the present invention, particularly amide group-CAB.Preferably have the aliphatic alkyl of 8-18 carbon atom and preferably have straight chain.These trimethyl-glycines are preferred, because think that they contain the nitra-amine precursor of low amount, though the trimethyl-glycine that can use other in composition of the present invention alkyl betaine for example.
For common composition, usually the amount of amphoterics is 0.01-8%, particularly 1-5% (weight), preferred about 2% (weight), and its concentration can reach 4 times in so-called concentrated product.When using nonionogenic tenside, the amount that will use in sprayable product is less, about 0.05-1%, and usage quantity is bigger in enriched material, general about 4% weight.
Preferably, composition of the present invention should be not have or have a spot of anion surfactant.Preferably the amount of anion surfactant is less than 33% weight of total surfactant, and the amount of preferred anionic surfactants tensio-active agent is 10% weight of total surfactant.
Also can use metal ion chelation agent, comprise edetate, amino poly-phosphate is (for example at DEQUEST
RThose of scope) and phosphoric acid salt and multiple other multi-functional organic acid and salt.It is believed that by existing metal ion chelation agent can improve the sanitation performance of said composition.
For acidic composition, as the maintenance said composition of this function be at the pH of diluted state 3-5 buffer reagent particularly preferably be Citrate trianion.Can use other buffer reagent.
Usually the amount of Citrate trianion is 0.5-5%, and the bigger amount that is used in the enriched material is 5-10%, and the less amount that is used in the spray-type products is 0.1-1%.Can replace citric acid with other suitable reducing, keep pH in this scope.Consider the reason and the little residual thing of environment, also optimization citric acid is sour because it is price/weight ratio.
Suitable hydrotropic agent comprise basic metal tosylate, urea, basic metal dimethylbenzene and cumene sulfonate, polyoxyethylene glycol,＞the pure and mild ethylene glycol of 20EO ethoxylation.In the middle of this, preferred hydrotropic agent is a sulfonate, particularly isopropyl benzene, dimethylbenzene and tosylate.For sulfonate, the amount of the general hydrotropic agent that adds is 0-5%.Sprayable product for dilution does not always need hydrotropic agent, if but just may need hydrotropic agent when using the ethoxylate of less EO or longer alkyl or need improve cloud point significantly.Cumene sulfonate is most preferred hydrotropic agent.
Composition of the present invention is except containing the component of mentioning already, also can contain various other optional components, for example other solvent, tinting material, white dyes, soil-suspending agent, detergent enzyme, compatible SYNTHETIC OPTICAL WHITNER, gel control agent, freeze-thaw stabiliser, other sterilant, spices and opalizer.
The of the present invention most preferred prescription that does not comprise accessory constituent comprises:
Weight/volume %
A) sodium carbonate decahydrate 1.14
Sodium bicarbonate 0.08
Dobanol?91-8???????????????????5.0
Thymol 1.0
Water to 100
B) sodium carbonate decahydrate 1.14
Sodium bicarbonate 0.08
Dobanol?91-8???????????????????5.0
Isothymol 1.0
Water to 100
For a better understanding of the present invention, will the present invention be described with reference to the following examples.
Embodiment
Embodiment 1: the alcohol ethoxylate tensio-active agent:
Use " Microbank " [TM] stocking system (Pro-Lab Diagnostics, Bromborough, UK). preserve microbial culture medium at-80 ℃, by from each bottle, removing cryo-preservative, and be inoculated into desired turbidity with nutrient solution, cryo-preservative is rotated back in the bottle that contains globule in this way each bottle (25) that contains 25 globules is inoculated simultaneously again.Manufacturers points out to remove subsequently cryo-preservative.
At-80 ℃ the globule that contains microorganism (intestinal bacteria) is taken out from stocking system, in Nutrient Broth No.2 (by Oxoid Unipath[TM] provide), in the shaking water bath of 37 ℃ of constant agitation speed, cultivated 24 hours.By culture is transferred in the 50ml centrifuge tube, at Mistral[TM] centrifugal 10 minutes of 4100rpm among 1000 Centrifuge, and be resuspended in that (peptone 0.1%, sodium-chlor 0.85%) reclaims cell in the maximum diluent that reclaims.This method obtains 10
9-10
10The bacterial suspension of cfu/ml.
The diluent that reclaims with maximum dilutes 10 times to this suspension, and sample is exposed in the testing liquid of nonionogenic tenside and aromatic alcohol or phenol, and by listed control prescription among the table 1-4 below.In embodiment 2a-2b, provided acidic formulation.
Method with microculture is carried out all tests: in 20 ℃ of preparations with 1 to 30 dilution, 5 minutes duration of contact.Mixture buffer preparation with yellow soda ash (1.14w/v% decahydrate) and sodium bicarbonate (0.08w/v%) is 10.5 to pH, lists in the table with the pH after the distilled water diluting.
In the middle of these tests, used nonionogenic tenside is Dobanol 91-8[TM], shown in pure and mild phenol is thought as follows:
The popular name systematic name
BA: benzylalcohol phenylcarbinol
The PEA:-2-phenylethyl alcohol
THY: thymol 2-sec.-propyl-5-sylvan
CAR: isothymol 5-sec.-propyl-2-sylvan
EUG: Eugenol 2-methoxyl group-4-[2-propenyl] phenol
After the exposure, by on Tryptones-soy agar, measuring microorganism alive in 24/48 hour in 30/37 ℃ of cultivation.Determine the reduction value of denary logarithm from the bacterial count of living by four multiple methods.
Shown between nonionogenic tenside and aromatic alcohol or the phenol among the table 1-4 and optionally acted synergistically.All concentration is in mM for phenol and alcohol, is in % (weight) for tensio-active agent.Embodiment of the present invention (the embodiment 5-7 in the table 1,11-13,17-19,22-23 and 26-27) in the text of runic, have been provided.
Under these test conditionss, the logarithm kill ratio that provides is coarse greater than 5 result, and the meaning is to kill fully or almost completely.By the result that provides of table 1-4 as can be seen, there is not tangible anti-microbial property at central (seeing comparative example 1) the independent nonionogenic tenside of this test.
When using separately, only thymol has significant anti-microbial property, and only when amount be that 2.23mM (being 4.47mM: see embodiment 16) just has anti-microbial property when above.But phenol and alcohol show the obvious synergistic effect with combining of nonionogenic tenside.
Table 1 is implemented the tensio-active agent example
The average logarithm of BA PEA THY CAR EUG reduces by 1 0.17-----0.962-3.1----0.043-6.2----0.004-31.0----0.215,0.17 3.1----2.076,0.17 6.2----2.227,0.17 31.0----2.838--2.75---0.009--5.5---0.0110--13.67---0.001,1 0.17-2.75---2.1812 0.17-5.5---2.3613 0.17-13.67---2.7814---1.125--0.0015---2.23--0.4916---4.4 7--7.9417 0.17--1.125--4.6518 0.17--2.23--7.9419 0.17--4.47--7.9420----1.12-0.9721----2.23-1.4022 0.17---1.12-5.2623 0.17---2.23-6.9924-----2.03 0.9125-----4.07,1.0126 0.17----2.03,4.0427 0.17----4.07 4.43
Table 2: with the synergy of thymol (2-sec.-propyl-5-sylvan)
| ????Dobanol ????91-8(％) | Thymol (%) | PH (dilution) | Colibacillary average logarithm reduction value | Standard deviation |
| ????5.0 | ????0 | ????9.4 | ????1.0 | ????0.3 |
| ????0 | ????0.5 | ????10.3 | ????0 | ????0 |
| ????5.0 | ????0.5 | ????10.3 | ????4.7 | ????0.3 |
| ????0 | ????1.0 | ????10.2 | ????0.5 | ????0.3 |
| ????5.0 | ????1.0 | ????10.3 | ????＞7.9 | ????0 |
Table 2a: (pH4.00) uses the synergy of thymol under acidic conditions
| Dobanol?91-8 ???(％) | Thymol (%) | PH (dilution) | The average logarithm reduction value of streptococcus aureus |
| ????0 | ????0 | ????4.0 | ????0.25 |
| ????5.0 | ????0 | ????4.0 | ????0.79 |
| ????0 | ????0.5 | ????4.0 | ????0.11 |
| ????5.0 | ????0.5 | ????4.0 | ????0.03 |
| ????0 | ????1.0 | ????4.0 | ????0.15 |
| ????5.0 | ????1.0 | ????4.0 | ????2.48 |
Table 2b: (pH5.00) uses the synergy of thymol under acidic conditions
| ??Dobanol?91-8 ????(％) | Thymol (%) | PH (dilution) | The average logarithm reduction value of streptococcus aureus |
| ????0 | ????0 | ????5.0 | ????0.14 |
| ????5.0 | ????0 | ????5.0 | ????0.07 |
| ????0 | ????0.5 | ????5.0 | ????0.17 |
| ????5.0 | ????0.5 | ????5.0 | ????0.26 |
| ????0 | ????1.0 | ????5.0 | ????0.04 |
| ????5.0 | ????1.0 | ????5.0 | ????1.28 |
Table 3: with the synergy of 2-phenylethyl alcohol
| ??Dobanol ??91-8(％) | 2-phenylethyl alcohol (%) | PH (dilution) | Colibacillary average logarithm reduction value | Standard deviation |
| ????5.0 | ????0 | ????9.4 | ????1.0 | ????0.3 |
| ????0 | ????1.0 | ????10.4 | ????0 | ????0 |
| ????5.0 | ????1.0 | ????10.2 | ????2.2 | ????0.2 |
| ????0 | ????2.0 | ????10.3 | ????0.0 | ????0.0 |
| ????5.0 | ????2.0 | ????10.3 | ????2.4 | ????0.4 |
| ????0 | ????5.0 | ????10.3 | ????0 | ????0 |
| ????5.0 | ????5.0 | ????10.3 | ????2.8 | ????0.5 |
Table 4: with the synergy of benzylalcohol
| ??Dobanol ??91-8(％) | Benzylalcohol (%) | PH (dilution) | Colibacillary average logarithm reduction value | Standard deviation |
| ????5.0 | ????0 | ????9.4 | ????1.0 | ????0.3 |
| ????0 | ????1.0 | ????10.3 | ?????0 | ????0.1 |
| ????5.0 | ????1.0 | ????10.2 | ?????2.1 | ????0.1 |
| ????0 | ????2.0 | ????10.4 | ?????0.0 | ????0.0 |
| ????5.0 | ????2.0 | ????10.3 | ?????2.2 | ????0.4 |
| ????0 | ????10.0 | ????10.4 | ?????0.2 | ????0.4 |
| ????5.0 | ????10.0 | ????10.2 | ?????2.8 | ????0.5 |
Embodiment 2: amine oxide
Method with microculture is carried out all tests: in 20 ℃ of preparations with 1 to 30 dilution, 5 minutes duration of contact.Mixture buffer preparation with yellow soda ash (1.14w/v% decahydrate) and sodium bicarbonate (0.08w/v%) is 9.5 (regulating with hydrochloric acid) to pH.In the final preparation of all embodiment that finish, the amount of active ingredient is 7% weight before dilution.The ultimate density of thymol in clean preparation (for example Sigma) is 1% weight.The C8 amine oxide is Admox8 (TM:ex.Albemarle), and the C12 amine oxide is Admox12 (TM:ex.Albemarle).After the exposure, by on Tryptones-soy agar, measuring microorganism alive in 24/48 hour in 37 ℃ of cultivations.Determine the reduction value of denary logarithm to the results are shown in following table 5 from the bacterial count of living by four multiple methods.
Table 5: amine oxide preparation
| Amine oxide | Streptococcus aureus | Streptococcus aureus (+thymol) | Intestinal bacteria | Intestinal bacteria (+thymol) |
| Do not have | ????0.0 | ????0.05 | ????0.0 | ????0.28 |
| ????C8 | ????0.4 | ????4.3 | ????0.3 | ????＞5.0 |
| ??C8+C12 | ????0.4 | ????5.0 | ????0.2 | ????＞5.0 |
| ????C12 | ????0.7 | ????1.8 | ????0.6 | ????＞5.0 |
By the result as can be seen, for the mixture of C8 amine oxide and C8 amine oxide and C12 amine oxide, the synergistic increase of the bio-bactericidal activity aspect that the mixture of amine oxide and thymol obtains surpasses amine oxide or thymol itself.
Claims (11)
1. a pH is greater than 9 or less than the composition of 5 nothing wearing and tearing with anti-microbial activity, it comprises:
A) aromatic alcohol or the phenol of the optional replacement of 0.15-15% (weight), rather than phenol itself with following general formula:
HO.R
1.Aryl(R
2)
n
Wherein: R
1Do not exist or R
1Be C1-C6 alkyl, alkenyl or alkoxyl group, R
2Do not exist or the ring substituents of the one or more C1-C6 of being selected from alkyl, alkenyl or alkoxyl group, n be 0-5 and
B) HLB of 0.1-30% (weight) is the alkanol nonionogenic tenside or the amine oxide of the ethoxylation of 9-14.
2. according to the composition of claim 1, wherein nonionogenic tenside is that each molecule has 4-10 oxyethyl group, chain length is C
8-C
14Ethoxylated alcohol.
3. according to the composition of claim 1, wherein nonionogenic tenside is single C
6-C
12Alkyl dimethyl amine oxide.
4. according to the composition of claim 1, comprising R
2Base or group are selected from the phenol of sec.-propyl, methyl, methoxyl group and 2-propenyl.
5. according to the composition of claim 1, comprising at least one substituent R
2Be the phenol that is positioned at the 2-position or the 5-position of phenol.
6. according to the composition of claim 1, comprising R
1There is not the phenol of n=2.
7. according to the composition of claim 1, comprising phenol or aromatic alcohol be selected from 5-methyl (2-isopropyl-phenol), 2-phenylethyl alcohol, 2-methoxyl group-4[2-propenyl] phenol, 5-sec.-propyl-2-sylvan, benzyl alcohol or their mixture.
8. according to the composition of claim 1, the log (P of aromatic alcohol or phenol wherein
Oct) greater than 1, P
OctIt is the octanol/water partition ratio of alcohol or phenol.
9. according to the composition of claim 1, wherein the ratio of nonionogenic tenside and aromatic alcohol or phenol is 20: 1-1: 1.
10. optional aromatic alcohol that replaces or phenol improve Application of Additives as antimicrobial acivity in the composition of claim 1.
11. the method for a clean surface, it comprises the step with the said surface of compositions-treated of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97196126 CN1224444A (en) | 1996-07-03 | 1997-06-10 | Antimicrobial cleaning compositions contg. aromatic alcohols or phenols |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9613967.0 | 1996-07-03 | ||
| CN 97196126 CN1224444A (en) | 1996-07-03 | 1997-06-10 | Antimicrobial cleaning compositions contg. aromatic alcohols or phenols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1224444A true CN1224444A (en) | 1999-07-28 |
Family
ID=5179583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 97196126 Pending CN1224444A (en) | 1996-07-03 | 1997-06-10 | Antimicrobial cleaning compositions contg. aromatic alcohols or phenols |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1224444A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105726523A (en) * | 2016-04-08 | 2016-07-06 | 中国农业科学院兰州畜牧与兽药研究所 | Drug composition for treating animal acariasises and preparation method and application thereof |
| CN105555133B (en) * | 2013-09-24 | 2017-12-12 | 萨特隆股份公司 | Antimicrobial compositions and the tissue containing the composition |
-
1997
- 1997-06-10 CN CN 97196126 patent/CN1224444A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105555133B (en) * | 2013-09-24 | 2017-12-12 | 萨特隆股份公司 | Antimicrobial compositions and the tissue containing the composition |
| CN105726523A (en) * | 2016-04-08 | 2016-07-06 | 中国农业科学院兰州畜牧与兽药研究所 | Drug composition for treating animal acariasises and preparation method and application thereof |
| CN105726523B (en) * | 2016-04-08 | 2018-03-09 | 中国农业科学院兰州畜牧与兽药研究所 | It is a kind of to be used to treat pharmaceutical composition of animal acariasis and its preparation method and application |
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