CN1222072A - Method and compsn. for skin lightening - Google Patents
Method and compsn. for skin lightening Download PDFInfo
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- CN1222072A CN1222072A CN 97195513 CN97195513A CN1222072A CN 1222072 A CN1222072 A CN 1222072A CN 97195513 CN97195513 CN 97195513 CN 97195513 A CN97195513 A CN 97195513A CN 1222072 A CN1222072 A CN 1222072A
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Abstract
A method and composition is provided for treating skin to achieve lightening by employing an active of the structure: (I) wherein R is selected from the group consisting of hydrogen, hydroxy and C1-C30 alkyl or aryl groups radicals; and R1 is selected from the group consisting of hydrogen and C1-C30 alkyl or aryl radicals.
Description
Background of the present invention
The field of the invention
The present invention relates to the method and composition that makes skin light gorgeous.
Association area
Since people freckle or hyperpigmentation occurred on the face first, people always need be for their Therapeutic Method.Historical Therapeutic Method relates to mercurial, plant extract and Fructus Citri Limoniae juice.It is reported with other salt of ammonification hydrargyrum and this metal quite effective for brightening of skin.Certainly, the significant safety issue that relates to mercurial is arranged.
Zinc peroxide is used in the anhydrous ointment as brightening agent.Hydroquinone-benzyl oxide puts goods on the market the effect of skin lightening owing to it, but also produces the problem of safety.
Think ascorbic acid preparation, perhaps for pure product or by some natural materials for example the Fructus Citri Limoniae juice preparation be useful.Because as if as if as safe as a house, they are so ineffective.
U.S patent 4096240 (Mathur) points out that nicotinic acid is effective skin lightening agent.Suppose that this material enters epidermis and works by delaying melanocyte and disperse or distributing.Because nicotinic acid produces skin rubefaction beastly, this patent suggestion substitutes with nicotiamide.Compositions based on nicotiamide is effectively, but very limited.
Therefore, the purpose of this invention is to provide skin lightening compositions and can finish this function effectively, known substances is more effective and can use safely at present for its.
Another object of the present invention provides the skin lightening compositions and can finish this function effectively, and it can resist senile plaque, freckle and hyperpigmentation especially effectively.
Consider following summary and detailed description, these and other objects of the present invention will be more apparent.
The present invention's summary
Make the gorgeous method of skin light provide the chemical compound that comprises the formula I structure that is applied to skin:
Wherein R is selected from hydrogen, hydroxyl and C
1-C
30Alkyl or aryl; And R
1Be selected from hydrogen and C
1-C
30Alkyl or aryl.
The skin lightening compositions also is provided, and it comprises:
(ⅰ) active substance with structure (I) of acquisition skin lightening effective dose;
(ⅱ) sunscreen of 0.1-30% (weight); With
(ⅲ) pharmaceutically acceptable carrier is with the material and the sunscreen of releasing structure (I).
The present invention describes in detail
Have been found that vanillin, vanillic acid and its derivant are the activating agent of skin lightening.These active substances can prevent hyperpigmentation, senile plaque and freckle effectively.They also can be used to increase gorgeous skin.They have following universal architecture (I):
Wherein R is selected from hydrogen, hydroxyl and C
1-C
30Alkyl or aryl, R
1Be selected from hydrogen and C
1-C
30Alkyl or aryl.
The active substance that preferably is used for this method and compositions is vanillin and vanillic acid.
The amount of active substance (I) can be 0.1-20%, and preferred 0.5-10% is suitably for 1-5% (weight).
The use of (I) can be according to the compositions repeated application that will contain active substance in the scheme of skin same area.For example, before the obvious light of skin is gorgeous, can be during several days to several weeks in every day use.In preferred embodiments, this method and compositions can be used for eliminating or alleviating senile plaque and/or freckle.Further being applied as of this method and compositions eliminated or alleviated pigmentation.
Another aspect of the present invention, owing to absorb the existence of ultraviolet sunscreen, the effect of skin lightening active substance (I) is the reverse of guaranteeing to resist melanin pigmentation.Term " sunscreen " is meant any organic or inorganic material that can block ultraviolet radiation for skin.Preferably it is effective in the scope of 290-400nm.
When sunscreen was organic substance, it contains usually at least aly can be absorbed in ultraviolet colour former in the 290-400nm scope.The organic sunscreen agent of color development can be divided into following kind (comprising special example), comprising: Para-Aminobenzoic, its salt and derivant thereof (ethyl, isobutyl group, glyceride; Right-dimethylaminobenzoic acid); O-aminobenzoa (o-aminobenzoa; Methyl, methyl, phenyl, benzyl, phenethyl, linalyl, tyerpinyl and cyclohexenyl group ester); Salicylate (octyl group, amyl group, phenyl, benzyl, menthyl, glyceryl and diallyl diol ester); Cinnamic acid derivative (menthyl and benzyl ester, α-phenyl cinnamonitrile; Butyl cinnamoyl pyruvate); Dihydroxycinnamic acid derivant (umbelliferone, methyl-umbelliferone, methyl acetyl-umbelliferone); Trihydroxy cinnamic acid derivative (esculetin, methyl esculetin, daphnetin and glucoside, Esculin and daphnin); Hydrocarbon (diphenyl diethylene, stilbene); Dibenzalacetone and benzalacetophenone; Naphthol sulfonate (beta naphthal-3,6-disulfonic acid and beta naphthal-6, the sodium salt of 8-disulfonic acid); Dihydroxy-naphthoic acid and salt thereof; Adjacent-and right-hydroxy diphenyl disulfonate; Coumarin derivative (7-hydroxyl, 7-methyl, 3-phenyl); Diazol (2-acetyl group-3-bromo indazole, benzene base benzoxazole, methyl naphtho-oxazole (naphthoxazole), various aryl benzothiazole); Quine salt (disulfate, sulfate, hydrochlorate, oleate and tannate); Quinoline (oxinate, 2-phenylchinoline); The benzophenone that hydroxyl or methoxyl group replace; Uric acid and Vilouric acid; Tannin and derivant thereof (as: Hexaethyl ether); (butyl carbityl) (6-propyl group piperonyl) ether; Hydroquinone; Benzophenone (oxybenzone, sulisobenzone, dihydroxyphenyl ketone, 2,4-dihydroxy benzophenone, 2,2 ', 4,4 '-four hydroxyl benzophenone, 2,2 '-dihydroxy-4,4 '-dimethoxy benzophenone, octabenzone; 4-isopropyl diphenyl formoxyl methane, PAROSOL 1789; Etocrylene; With 4-isopropyl-dibenzoyl methane).
Special use is: the 2-ethylhexyl is right-Methoxycinnamate; 4; 4 '-tert-butyl methoxy dibenzoyl methylmethane; 2-hydroxyl-4-methoxyl group benzophenone; the octyldimethyl Para-Aminobenzoic, tannic acid acyl group trioleate, 2; 2 '-dihydroxy-4-methoxyl group benzophenone; ethyl-4-[two (hydroxypropyl)] Aminobenzoate, 2-ethylhexyl-2-cyano group-3,3 '-diphenylacrylate ester; the 2-Ethylhexyl salicylate; the glyceryl p-aminobenzoate, 3,3; 5-trimethylcyclohexyl salicylate; the methyl o-aminobenzoa, right-dimethylaminobenzoic acid or Aminobenzoate, 2-ethylhexyl ESCAROL 507 salt; 2-Phenylbenzimidazole-5-sulfonic acid, 2-(right-dimethylaminophenyl)-5-sulfonio benzoxazole acid and composition thereof.
What be fit to can be as shown in the table available from the organic sunscreen agent of commerce:
The table I
| The CTFA name | Trade name | Supplier |
| Benzophenone-3 | UVINUL?M-40 | BASF?Chemical Co. |
| Benzophenone-4 | UVINUL?MS-40 | BASF?Chemical Co. |
| Benzophenone-8 | SPECTRA-SORB UV-24 | American Cyanamid |
| The DEA-Methoxycinnamate | BERNEL?HYDRO | Bemel?Chemical |
| Ethyl dihydroxypropyl-PABA | AMERSCREEN?P | Amerchol?Corp. |
| Glyceryl PABA | NIPA?G.M.P.A. | Nipa?Labs. |
| Homosalate | KENESTER?HMS | Humko?Chemical |
| The menthyl o-aminobenzoa | SUNAROME?UVA | Felton?Worldwide |
| Octocrylene | UVINUL?N-539 | BASF?Chemical Co. |
| Octyldimethyl PABA | AMERSCOL | Amerchol?Corp. |
| Octyl methoxycinnamate | PARSOL?MCX | Bemel?Chemical |
| The octyl group salicylate | SUNAROME WMO | Felton?Worldwide |
| PABA | PABA | National?Starch |
| 2-Phenylbenzimidazole-5-sulfonic acid | EUSOLEX?6300 | EM?Industries |
| The TEA salicylate | SYBARINE?W | Felton?Worldwide |
| 2-(4-methyl benzlidene)-Camphora | EUSOLEX?6300 | EM?Industries |
| Benzophenone-1 | UVINUL?400 | BASF?Chemical Co. |
| Benzophenone-2 | UVINUL?D-50 | BASF?Chemical Co. |
| Benzophenone-6 | UVINUL?D-49 | BASF?Chemical Co. |
| Benzophenone-12 | UVINUL?408 | BASF?Chemical Co. |
| 4-isopropyl diphenyl formoxyl methane | EUSOLEX?8020 | EM?Industries |
| PAROSOL 1789 | PARSOL?1789 | Givaudan?Corp. |
| Etocrylene | UVINUL?N-35 | BASF?Chemical Co. |
But the inorganic sunscreen active component is application examples such as fine titanium dioxide, zinc oxide, polyethylene, polyamide (as nylon) and various other polymer also.The amount general range of sunscreen (no matter being organic or inorganic) is 0.1-30%, preferred 2-20%, and the best is 4-10% (weight).
Compositions of the present invention is used pharmaceutically acceptable carrier.Carrier can be aqueous, anhydrous or Emulsion.Preferred composition is the water of aqueous particularly W/O or O/W type and the Emulsion of oil.When water existed, the amount of water can be preferably 20-70% in the scope of 5-95%, and the best is between the 35-60% (weight).
Outside dewatering, the solvent of relative volatility also can be used as the carrier in the present composition.Most preferably be monohydroxy C
1-C
3Alkanol.They comprise ethanol, methanol and isopropyl alcohol.The amount of monohydroxy alkanol can be preferably 10-50% in the scope of 1-70%, the best is between the 15-40% (weight).
The softening agent material also can be used as pharmaceutically acceptable carrier.These materials can be the form of silicone oil or synthetic ester.The amount of softening agent can be in the 0.1-30% scope, preferred 1-20% (weight).
Silicone oil is divided into volatility and non-volatile two kinds.Terminology used here " volatility " is meant those materials that can measure vapour pressure when room temperature.Volatile silicone oils can be preferably from the ring-type or the linear polydimethylsiloxane-that contain the individual silicon atom of 3-9 (preferred 4-5).
Generally the viscosity in the time of 25 ℃ is less than about 5 centistokes for linear volatile siloxane material, and the general viscosity of annular material is less than about 10 centistokes.
The non-volatile silicone oil that uses as the softening agent material comprises poly-alkylsiloxane, polyoxyethylene alkyl aryl radical siloxane and polyether siloxane copolymer.Basic non-volatile poly-alkylsiloxane used herein comprises that viscosity is from about 5 polydimethylsiloxane to about 100,000 centistokes during as 25 ℃.Viscosity was for from about 10 polydimethylsiloxane to about 400 centistokes when the preferred non-volatile softening agent that is used for the present composition was 25 ℃.
The esters softening agent is:
(1) has the alkenyl or the Arrcostab of the fatty acid of 10-20 carbon atom.Its example comprises neopentanoic acid Isoeicosane ester, isonanonoate ester in the different ninth of the ten Heavenly Stems, tetradecanoic acid vaccenic acid ester, stearic acid vaccenic acid ester and oleic acid vaccenic acid ester.
(2) fatty acid ester of the aliphatic alcohol of ether-ether such as ethoxylation.
(3) polyhydroxy alkyl ester.Glycol monomethyl or two-fatty acid ester, diethylene glycol list or two-fatty acid ester, Polyethylene Glycol (200-6000) is single or two-fatty acid ester, propylene glycol list or two-fatty acid ester, polypropylene glycol list or two-fatty acid ester, polypropylene glycol 2000 monoleates, polypropylene glycol 2000 monostearates, ethoxylation propylene glycol 2000 monostearates, glyceryl list or two-fatty acid ester, polyglycereol gathers fatty ester, ethoxylated glyceryl monostearate, 1,3-butanediol monostearate, the two stearates of 1,3 butylene glycol, the polyoxyethylene polyols fatty acid ester, fatty acid esters of sorbitan and polyoxyethylene sorbitan fatty acid ester all are good polyhydroxy alkyl esters.
(4) wax ester such as Cera Flava, spermaceti, myristyl myristate, stearoyl stearate (stearyl strerate) and behenic acid eicosane ester.
(5) sterol ester, wherein cholesterol fatty acid ester is its example.
Fatty acid with 10-30 carbon atom also can be used as pharmaceutically acceptable carrier of the present invention.Such example is n-nonanoic acid, lauric acid, myristic acid, Palmic acid, stearic acid, isostearic acid, hydroxy stearic acid, oleic acid, linoleic acid, ricinoleic acid, arachidic acid, behenic acid and erucic acid.
The wetting agent of polyhydroxy alcohols also can be as the pharmaceutically acceptable carrier among the present invention.Wetting agent helps to improve the effect of softening agent, reduces squama and generates the sensation that the back stimulation has formed the elimination of squama and improved skin.Typical polyhydroxy-alcohol comprises glycerol, poly alkylene glycol and more preferably alkylidene polyol and derivant thereof, comprise propylene glycol, dipropylene glycol, polypropylene glycol, Polyethylene Glycol and derivant thereof, sorbitol, hydroxypropyl sorbitol, hexanediol, 1,3-butanediol, 1,2,6-hexanetriol, ethoxylated glycerol, propoxylated glycerol and composition thereof.For obtaining best result, the preferred propylene glycol of wetting agent.The amount of wetting agent can any scope between 0.5-30% in, preferably between the 1-15% of composition weight.
Also can use the pharmaceutically acceptable carrier of thickening agent as the part present composition.Typical thickeners comprises that cross-linked acrylic acid fat 1 is (as Carbopol 982
), hydrophobic-improvement acrylate (as Carbopol 1382
), cellulose derivative and natural gum.The cellulose derivative of using is sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, hydroxyethyl-cellulose, ethyl cellulose and hydroxy methocel.Suitable natural gum of the present invention comprises guar gum, xanthan gum, sclerotium, carrageenin, pectin and compositions thereof.The amount of thickening agent can be generally 0.001-1% in the scope of 0.0001-5%, the best is 0.01-0.5% (weight).
Set water, solvent, siloxanes, ester, fatty acid, wetting agent and/or thickening agent are formed pharmaceutically acceptable carrier, and its amount is preferably 80-99% (weight) for 1-99.9%.
Cosmetic composition of the present invention can be any form.These forms can comprise emulsification system such as lotion and cream, microemulsion, ball (roll-on) preparation, mousse, ointment (hydrophilic and hydrophobicity), aerosol and non-aerosol spray and pad-applied preparation.Surfactant also may reside in the compositions of the present invention.The total concentration scope of surfactant is 0.1-40%, is preferably 1-20%, the best 1-5% (in the weight of compositions) of being.Described surfactant can be selected from anion, nonionic, cation and amphiprotic activity material.Particularly preferred non-ionic surface active agent is for having C
10-C
20Those of aliphatic alcohol or be the oxirane of every mole of hydrophobe and 2-100 mole or the sour hydrophobe of expoxy propane condensation; C with the condensation of 2-20 mole alkylene oxide
10-C
20Alkyl phenol; One or di fatty acid ester of ethylene glycol; Glycerine monofatty ester; Anhydro sorbitol, one or two C
8-C
20Fatty acid; Block copolymer (ethylene oxide/propylene oxide); Polyethenoxy sorbitan and their combination.Alkyl polyglucoside and glycolipid fat amide (as methyl glucose amide) also are the non-ionic surface active agents that is fit to.
The preferred anionic surfactants surfactant comprises soap, alkyl ether sulphate and sulphonic acid ester, alkyl sodium sulfate ester and alkyl sulfonate esters, benzene sulfonamide acid esters, alkyl and dialkyl sulfosuccinate succinyl ester C
8-C
20Acyl-hydroxyethyl sulfonate, acyl glutamic acid ester, C
8-C
20Alkyl ether phosphate and its combination.
In compositions of the present invention, can add antiseptic as required to prevent potential harmful microbe growth.The suitable traditional preservatives of the present composition is an alkyl paraben.Other antiseptic of most recently used comprises hydantoin derivatives, propionate and various quaternary ammonium salt chemical compound.The cosmetic chemistry man is familiar with suitable antiseptic and can selects them to satisfy anticorrosion experiment and stable product is provided routinely.Special preferred preservative is phenyl phenol, methyl para-amino benzoic acid (paraben), propyl group para-amino benzoic acid, imidazolidinyl urea, dehydro sodium acetate and benzylalcohol.Should consider the application of compositions when selecting antiseptic and possible incompatibility between antiseptic and other composition in Emulsion.The scope of the amount of antiseptic advantageous applications is 0.01%-2% (in the weight of compositions).
Keratolytic such as C
2-C
30, preferred C
2-C
25, alpha-hydroxy carboxylic acid compounds and beta-hydroxycarboxylic acids and salt thereof also can be included in the present composition, also can be applicable in this method, and representative substances is hydroxyacetic acid, lactic acid, salicylic acid, Alpha-hydroxy is sad and salt.Above-mentioned salt can be selected from alkali metal, ammonium and C
1-C
20Alkyl or pure ammonium counter ion.The level of these keratolytics can be suitable in the scope of 0.001-10%, preferably between 0.2-8%, the best is between the 1-4% (weight).
In said composition, also can there be a spot of adjuvant.Wherein they can be for example vitamin A palmitate, vitamin E acetate and DL-pantothenylol of water-fast vitamin.
Compositions of the present invention also can comprise coloring agent, aromatic, opacifier and grinding agent.These materials can be in about 5% scope of for example about 0.05-, preferably in 0.1-3% (weight) scope.
The following example more proves absolutely embodiment of the present invention.Except that specializing, all umbers, percentage ratio and ratio are in this and appended claims middle finger weight.
Embodiment 1
Carry out clinical experiment and make the gorgeous effectiveness of skin light to estimate vanillin.More particularly, described evaluation concentrates on the alleviating of pigment intensity of hyperpigmentation infringement.
This clinical research comprises 10 women members.These members screen from 120 women.Age is at 45-65 between year.The member's who selects forearm and hand need gently-the moderate photodamaged, i.e. hyperpigmentation, freckle, speckle color table face, gauffer and uneven color.Each member is coated with twice of two kinds of product (early morning and evening) every day after washing.A kind of product is applied to lower-left arm and left hand.Second kind of product is applied to the bottom right arm and the right hand.Measure down by elbow joint and make treatment and untreated skin boundary line by being used in 4 fingers that joint keeps flat.More than nethermost finger, do not use product.Estimate each member's substrate level then, per two weeks are estimated once in six all therapeutic processes.Each member avoids arm and hands are exposed under the sunlight during studying.But (being 5-10 minute) exposure is an acceptable once in a while.When any member thinks that its hands and arm can be exposed to sunlight when longer time, encourage her to put on caftan and use SPF to be at least 15 sunscreen product.
But use the still specific hyperpigmentation infringement image of analogy of Scopeman Fiber Optic each member's hands of microscopic examination and forearm back surfaces.With these image inputs CPVision Logic, Digital Image Processor.Use this instrument can measure variation and " normally " skin on every side, the optical density readings of each point and the size of each infringement of hyperpigmentation infringement.The base composition that use has a table II listed prescription in contrast.
The table II
Base composition
| Composition | Weight % |
| Lactic acid | ????8.0 |
| Butanediol | ????3.0 |
| Stearic acid | ????3.0 |
| Potassium hydroxide | ????2.7 |
| Isostearoyl base hexadecane acid esters | ????2.0 |
| Glycerol | ????2.0 |
| The PEG-100 stearate | ????2.0 |
| The glyceryl hydroxy stearic acid | ????1.5 |
| Stearyl alcohol | ?????1.5 |
| Triethanolamine | ?????1.2 |
| C 12-15The alkyl caprylate | ?????1.0 |
| Polydimethylsiloxane | ?????1.0 |
| Sorbitan monostearate | ?????1.0 |
| The methyl para-amino benzoic acid | ?????0.15 |
| Aluminium-magnesium silicate | ?????0.6 |
| Cholesterol | ?????0.5 |
| Hydroxyethyl-cellulose | ?????0.5 |
| Xanthan gum | ?????0.2 |
| The propyl group para-amino benzoic acid | ?????0.1 |
| The EDTA disodium | ?????0.05 |
| BHT | ?????0.05 |
| Dimethicone | ?????0.01 |
| Water | Balance to 100 |
When the 4-hydroxyl-3-methoxylbenxaldehyde that contains 2% in base composition, the pigment density among 10 participants in 9 people's the skin reduces.In a word, during above 6 weeks, 19% pigment density that the hyperpigmentation infringement occurs reduces.Believe that the hypopigmentation of using base composition is because the existence of lactic acid.Being added in above the pigment density that still further reduces the pigmentation infringement during 6 weeks of 4-hydroxyl-3-methoxylbenxaldehyde reaches 37.6%.On the statistics, " P "＜0.002.The table III is listed each participant's reaction.
The table III
Pigment density reduces
| Participant's numbering | The basis contrast | 2% Rhizoma et radix valerianae element is in substrate |
| ?????1 | ??????7.8 | ????????33.5 |
| ?????2 | ??????12.1 | ????????48.2 |
| ?????3 | ??????30.2 | ????????33.5 |
| ?????4 | ??????2.8 | ????????47.6 |
| ?????5 | ??????17.1 | ????????35.3 |
| ?????6 | ??????11.3 | ????????38.1 |
| ?????7 | ??????0.0 | ????????22.3 |
| ?????8 | ??????34.6 | ????????36.9 |
| ?????9 | ??????37.3 | ????????26.0 |
| ?????10 | ??????37.4 | ????????54.9 |
Embodiment 2
The table IV is listed microemulsion formulation of the present invention.
The table IV
| Composition | Weight (%) |
| PPG-5-Ceteth-20 | ?????4.00 |
| The PEG-40 castor oil hydrogenated | ?????1.75 |
| polyglyceryl-10Decaoleate | ?????10.50 |
| PEG-8 is sad/the certain herbaceous plants with big flowers acid glyceride | ?????10.50 |
| SD alcohol 40 | ?????12.00 |
| Different certain herbaceous plants with big flowers base neopentane ester | ?????16.00 |
| Glyceryl three caprylates | ?????8.00 |
| DCSILICONE?FLUID344 | ?????8.50 |
| The propyl group para-amino benzoic acid | ????0.15 |
| Isostearic acid | ????2.50 |
| 4-hydroxyl-3-methoxylbenxaldehyde | ????3.75 |
| Hydroxycaprylic acid | ????0.10 |
| Tocopherol acetas | ????0.25 |
| Phenoxyethanol | ????0.30 |
| Deionized water | In right amount |
Embodiment 3
The table V is listed skin lotion of the present invention (water-in-oil type) preparation.
The table V
| Composition | Weight (%) |
| The cetyl dimethicone | ????2.50 |
| DC?SILICONE?FLUID344 | ????4.00 |
| DC?SILICONE?FLUID200 (20 CST) | ????1.25 |
| Squalane | ????1.75 |
| Octyl octanoate | ????2.00 |
| Zinc myristate | ????1.25 |
| Dimethicone copolyol | ????2.50 |
| Butanediol | ????4.50 |
| Glycerol | ????1.50 |
| Hyaluronate sodium | ????1.00 |
| Vanillic acid | ????6.00 |
| Salacos?HS | ????2.50 |
| Isostearic acid | ????2.50 |
| Isononyl isononanoate | ????3.75 |
| Hydroxycaprylic acid | ???0.10 |
| The methyl para-amino benzoic acid | ???0.20 |
| The propyl group para-amino benzoic acid | ???0.10 |
| Tocopherol acetas | ???0.55 |
| Phenoxyethanol | ???0.20 |
| Deionized water | In right amount |
Embodiment 4
The skin creams of the present invention (oil-in-water type) that contains sun-proof thing preparation is listed in the table VI.
The table VI
| Composition | Weight (%) |
| Hydroxyethyl-cellulose | ?????0.50 |
| Aluminium-magnesium silicate | ?????0.75 |
| Cupu oil | ?????1.25 |
| Squalene | ?????1.05 |
| The different pelargonate of isostearoyl base | ?????2.25 |
| DC?Silicone?Fluid200 (50CST) | ?????1.25 |
| DC?Silicone?Fluid200 (10CST) | ?????0.50 |
| Butanediol | ?????3.00 |
| Parsol?MCX | ?????3.00 |
| Parsol1789 | ?????3.00 |
| Glycerol | ?????2.50 |
| Hyaluronate sodium | ?????0.50 |
| Vanillin | ?????5.00 |
| The Glycereth-7 hydroxy stearic acid ester | ?????1.50 |
| Stearic acid | ?????3.50 |
| Spermaceti/stearyl alcohol | ?????2.55 |
| PCA sodium | ????2.10 |
| Hydroxy stearic acid glyceride | ????1.25 |
| Tocopherol | ????0.35 |
| The methyl para-amino benzoic acid | ????0.20 |
| The propyl group para-amino benzoic acid | ????0.10 |
| Glydant | ????0.30 |
| Steareth-20 | ????1.20 |
| The EDTA disodium | ????0.05 |
| Triethanolamine | ????1.50 |
| Deionized water | In right amount |
Embodiment 5
The no water slurry agent (serum) that contains inorganic (titanium dioxide) sun-proof thing preparation of the present invention is listed in the table VII.
The table VII
| Composition | Weight (%) |
| Zinc oxide | ?????8.00 |
| Sepigel?305 | ?????1.50 |
| SD?Alcohol?40(200°) | ?????20.00 |
| Squalene | ?????1.05 |
| Different octyl pelargonate | ?????2.25 |
| DC?Silicone?Fluid200 (10CST) | ?????5.25 |
| Isononyl isononanoate | ?????30.00 |
| Butanediol | ?????1.00 |
| Vitamin E linoleate | ?????0.50 |
| The propyl group para-amino benzoic acid | ?????0.10 |
| Tocopherol acetas | ?????0.10 |
| Vanillin | ????2.75 |
| Dimethiconol | ????2.50 |
| DC?Silicone?Fluid344 | In right amount |
Embodiment 6
Be listed in the table below in the VIII according to skin lotion of the present invention (oil-in-water type).
The table VIII
| Composition | Weight (%) |
| Xanthan gum | ?????0.20 |
| Aluminium-magnesium silicate | ?????0.75 |
| Shea butter glyceride | ?????1.25 |
| Squalene | ?????2.25 |
| Cocoa caprylate/decanoin | ?????3.25 |
| DC?Silicone?Fluid?200 (50CST) | ?????0.75 |
| DC?Silicone?Fluid200 (50CST) | ?????0.50 |
| Butanediol | ?????3.00 |
| Glycerol | ?????2.00 |
| Hyaluronate sodium | ?????0.35 |
| Vanillic acid | ?????3.50 |
| Cetyl alcohol | ?????1.00 |
| P hydroxycinnamic acid A-hexadecane ester | ?????2.15 |
| The sugar isomerate | ?????1.00 |
| PCA sodium | ?????2.10 |
| The sucrose laruate | ?????0.50 |
| Ceteth-2 | ?????0.50 |
| The methyl para-amino benzoic acid | ?????0.20 |
| The propyl group para-amino benzoic acid | ?????0.10 |
| Germall?Ⅱ | ????0.30 |
| Steareth-20 | ????1.20 |
| Tocopherol acetas | ????0.20 |
| The EDTA disodium | ????0.05 |
| Lactic acid | ????0.10 |
| Deionized water | In right amount |
Embodiment 7
The lotion that contains the protection skin of sun-proof thing preparation of the present invention is listed in the table IX.
The table IX
| Composition | Weight (%) |
| Xanthan gum | ?????0.15 |
| Sepigel501 | ?????1.50 |
| The Shea butter | ?????1.50 |
| Squalene | ?????2.00 |
| Cocoa caprylate/decanoin | ?????2.25 |
| Propylene glycol dicaprylate/dicaprate | ?????3.55 |
| DC?Silicone?Fluid200 (20CST) | ?????0.50 |
| DC?Silicone?Fluid200 (350CST) | ?????1.00 |
| Butanediol | ?????3.00 |
| Glycerol | ?????1.00 |
| Hyaluronate sodium | ?????0.35 |
| Vanillin | ?????3.00 |
| Cetyl alcohol | ?????1.00 |
| P hydroxycinnamic acid A-hexadecane ester | ?????2.15 |
| Parsol?MCX | ?????6.00 |
| Benzophenone-3 | ?????3.00 |
| Ceteth-2 | ????0.50 |
| Ceteareth-20 | ????1.20 |
| The methyl para-amino benzoic acid | ????0.30 |
| The propyl group para-amino benzoic acid | ????0.15 |
| Glydant | ????0.20 |
| Aloe Vera Gel | ????1.00 |
| Tocopherol acetas | ????0.30 |
| The EDTA disodium | ????0.05 |
| Deionized water | In right amount |
Claims (12)
1. be used to the cosmetic method that makes skin light gorgeous, this method comprises that the chemical compound with structure (I) is applied on the skin,
Wherein R is selected from hydrogen, hydroxyl and C
1-C
30Alkyl or aryl, R
1Be selected from hydrogen and C
1-C
30Alkyl or aryl.
2. the process of claim 1 wherein that described active substance is selected from vanillin and vanillic acid.
3. claim 1 or 2 method, wherein senile plaque and/or freckle can be removed or reduce to skin lightening.
4. any one method of claim 1-3, wherein hyperpigmentation can be removed or reduce to skin lightening.
5. any one method of claim 1-4, this method also comprises the substance having sun-screening function that not existed by the effective dose of 290-400nm ultraviolet radiation with protection skin.
6. any one method of claim 1-5, this method also comprises C
2-C
30The combination of alpha-hydroxy carboxylic acid compounds or beta-hydroxycarboxylic acids or its salt or its two kinds of materials or more material is to be used for skin.
7. the make-up composition of skin lightening, it comprises:
(ⅰ) active substance with structure (I) of the effective dose of acquisition skin lightening:
Wherein R is selected from hydrogen, hydroxyl and C
1-C
30Alkyl or aryl, R
1Be selected from hydrogen and C
1-C
30Alkyl or aryl;
(ⅱ) sunscreen of 0.1-30% (weight); With
(ⅲ) pharmaceutically acceptable carrier is with the material and the sunscreen of releasing structure (I).
8. the compositions of claim 7, wherein said active substance is selected from vanillin and vanillic acid.
9. claim 7 or 8 compositions, wherein senile plaque and/or freckle can be removed or reduce to skin lightening.
10. any one compositions of claim 7-9, wherein hyperpigmentation can be removed or alleviate to skin lightening.
11. any one compositions of claim 7-10, it further comprises the sunscreen that not existed by the effective dose of the ultraviolet radiation of 290-400nm scope with protection skin.
12. any one compositions of claim 7-11, it further comprises the C of 0.001-10%
2-C
30The combination of alpha-hydroxy carboxylic acid compounds or beta-hydroxycarboxylic acids or its salt or its two kinds of materials or more material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97195513 CN1222072A (en) | 1996-06-14 | 1997-05-16 | Method and compsn. for skin lightening |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/663,829 | 1996-06-14 | ||
| CN 97195513 CN1222072A (en) | 1996-06-14 | 1997-05-16 | Method and compsn. for skin lightening |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1222072A true CN1222072A (en) | 1999-07-07 |
Family
ID=5179216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 97195513 Pending CN1222072A (en) | 1996-06-14 | 1997-05-16 | Method and compsn. for skin lightening |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1222072A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101862316A (en) * | 2010-05-21 | 2010-10-20 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Application of vanillic acid in prevention and treatment of radiation injury |
| CN101170990B (en) * | 2005-05-03 | 2012-11-07 | 荷兰联合利华有限公司 | Skin lightening composition comprising a conjugated linoleic acid and niacinamide |
-
1997
- 1997-05-16 CN CN 97195513 patent/CN1222072A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101170990B (en) * | 2005-05-03 | 2012-11-07 | 荷兰联合利华有限公司 | Skin lightening composition comprising a conjugated linoleic acid and niacinamide |
| CN101862316A (en) * | 2010-05-21 | 2010-10-20 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Application of vanillic acid in prevention and treatment of radiation injury |
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