CN1208609C - Liquid sample collector - Google Patents
Liquid sample collector Download PDFInfo
- Publication number
- CN1208609C CN1208609C CNB021261113A CN02126111A CN1208609C CN 1208609 C CN1208609 C CN 1208609C CN B021261113 A CNB021261113 A CN B021261113A CN 02126111 A CN02126111 A CN 02126111A CN 1208609 C CN1208609 C CN 1208609C
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- China
- Prior art keywords
- test paper
- sample
- main component
- liquid
- hole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
- A61B5/1405—Devices for taking blood samples
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/007—Devices for taking samples of body liquids for taking urine samples
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0825—Test strips
Abstract
A blood specimen collection device includes a main body provided with a passage extending between opposite ends of the main body that defines a capillary tube blood specimen flow path. One end of the passage opens at a tip end of the body member that is positionable adjacent a blood specimen for introducing the blood specimen into the passage while the opposite end of the passage opens at a body surface of the body which surrounds and extends outwardly from the opposite end of the passage. A test paper soaked in reagent is secured to the main body adjacent the opposite end of the passage. A blood sample introduced into the passage at the tip end of the body member flows by capillary action along the passage to the opposite end of the passage where the specimen is then absorbed by the test paper.
Description
Technical field
The present invention relates to the collecting device of blood and so on liquid sample, particularly collect blood and so on liquid sample and this liquid sample is applied on the test paper so that measure the equipment of the concentration of blood sugar and so on material in this liquid sample.
Background technology
Measure a kind of composition in the liquid sample or characteristic, for example the known method of the blood-sugar content in blood sample or the urine sample uses a test paper usually, has one to apply measurement section on it for the testing liquid sample on this test paper.During use, hold an end of this test paper and make its contact liq sample.
When using test paper to measure someone blood-sugar content, the taking blood sample with broken this people's of an acupuncture finger.Then test paper is clung to finger and go up the absorption blood sample.But this method of taking blood sample is problematic on a test paper.Because this method needs people's operation, and generally have to be used for analyzing to a small amount of blood sample, therefore blood sample can't accurately be applied on the measurement section of test paper sometimes.
U.S. Patent No. 5,100,620 disclose a kind of device that is called kapillary reagent formula device, thus it absorbs the collection blood sample with a test paper that is contained on this device.This device comprises a transparent body, wherein has a hole to extend between the opposite end of this main body.The shoulder that this test paper is contained in around main body one end upward forms a fluid passage between this test paper and this main body.There is an outlet passageway that this fluid passage is communicated with atmosphere in this main body.During use, the tip of main body contact blood sample, thus blood upwards sucks Kong Zhonghou influent passage in the main body by capillarity.Air when blood flows in the neutralising fluid passage of the hole of main body in the neutralising fluid passage of hole is discharged through outlet passageway.Blood is absorbed by test paper when the influent passage.Then this device is installed to the characteristic (for example blood-sugar content) of determining this blood sample on the reader.
This existing kapillary reagent formula device exists some problems and shortcoming.A problem is that this device must be shaped on outlet passageway in main body.This means, the mould that is used for making this main body must painstakingly design, so that form outlet passageway, thereby the cost of mould and complicacy improve, all the more so from following situation: for fear of the unsuitable evaporative cooling that this patent was called, the size of outlet passageway must be very little.In addition, in the hole that the shape at the tip of this device is difficult to make blood successfully flow into main body.And when this device being installed to the desirable characteristics of determining collected sample on the test paper on the reader, this reader can be subjected to the pollution of blood sample on the test paper.In addition, the shape of test paper is unsuitable for absorbing smoothly blood sample.
Summary of the invention
In view of the foregoing, the objective of the invention is to propose a kind of liquid-sample collection device, it need not to make the outlet passageway that is used for discharging air in this device use.
Another purpose of the present invention is to propose a kind of liquid-sample collection device, and it is convenient to liquid sample and goes into this gathering-device from the liquid sample source and course.
Also purpose of the present invention is to propose a kind of liquid-sample collection device, and it can not pollute this measuring equipment when the composition of measuring liquid sample or characteristic.
According to a kind of liquid-sample collection device of the present invention, this device can be contained in one and measure on the reading device of characteristic of liquid sample, this liquid-sample collection device comprises: a main component, have one to extend between this main component opposite end in this main component, all the hole of opening is used as kapillary sample stream at these two ends, one end opening in this hole is other and liquid sample is introduced the most advanced and sophisticated place in this hole at the be placed into liquid sample of this main component, and the other end opening in this hole is at a body surfaces place of this main component, this body surfaces is in the outwards stretching, extension all around of the other end in this hole, this main component tip has end surfaces and outer circumference surface, has at least one groove to extend between the hole of most advanced and sophisticated outer circumference surface and main component on the end surfaces at this main component tip; And test paper, this test paper comprises the blood absorbent portion that is used for the absorption liquid sample body and has positive and negative first and second, this test paper is fixed on the main component, make first this body surfaces of this test paper, thereby the liquid sample that flows into this hole at this place, tip flows to this other end and contacts this test paper along capillary liquid sample stream by capillarity over against this main component.
Preferably, test paper a plurality of isolated bonding positions on the test paper circumferential part cement on the main component, and are gapped between the adjacent bonding position, thereby air can flow in these gaps when liquid sample flows in capillary liquid sample stream.
Preferably, this test paper is the sheet that is arranged in a plane, and described test paper central authorities are provided with and reach the described out-of-plane projection that extends axially.
Preferably, this test paper is the sheet that is arranged in a plane, and this test paper comprises that a ring shaped axial that extends on the outer circumference portion of this test paper stretches projection, and described annular projection stretches out outside this plane of this test paper with the direction towards this body surfaces of this main component.
Preferably, described liquid-sample collection device comprises at least one projection, this at least one projection is from this body surfaces upper edge axial projections and be positioned at the radially outer in this hole, is used for making when this gathering-device installs on this reading device end face and the test paper of reading device to separate.
Preferably, described main component has a dimple that inserts for an end of reading device, and described dimple has a bottom surface of being defined by this body surfaces.
According to the present invention, can be contained in a liquid-sample collection device of measuring on the reading device of characteristic of liquid sample and comprise a main component, one end of this main component has a recess for this reading device insertion, the other end has one to be placed into the other sample introducing portion of liquid sample, have in this main component one in the hole of the first and second opposite end openings as kapillary sample stream.First end in this hole leads to this sample introducing portion, and second end in this hole leads to this recess.This main component is in the body surfaces that also has an outside stretching, extension all around of second end in this hole.Color reagent is arranged on it, comprise that positive and negative first and second 's a test paper is contained in the recess of main component, first of this test paper over against this body surfaces, thereby the liquid sample that flows into this hole at first end flows through by capillarity and flows to second end in this hole behind the capillary liquid sample stream and contact test paper.
According to another aspect of the present invention, be contained in a liquid-sample collection device of measuring on the reading device of characteristic of liquid sample and comprise a main component, have in this main component one extend between this main component opposite end, at these two ends all the hole of opening as kapillary sample stream.One end opening in this hole is other and liquid sample is introduced the tip in this hole at the be placed into liquid sample of this main component, and the other end opening in this hole is at a body surfaces place of this main component, and this body surfaces outwards stretches around the other end in this hole.This tip of this main component comprises an end face and an outer circumference surface, on this end face at this tip of this main component a groove is arranged.This groove extends between this outer circumference surface at this tip and is convenient to liquid sample and flows into this hole.Color reagent is arranged on it, comprise that positive and negative first and second 's a test paper is contained in the recess of main component, first this body surfaces of this test paper over against this main component, thus the liquid sample that flows into this hole at this tip flows to this other end and contacts test paper along capillary liquid sample stream by capillarity.
Another aspect of the present invention relates to one can be contained in a liquid-sample collection device of measuring on the reading device of characteristic of liquid sample, this liquid-sample collection device comprises a main component, have in this main component one extend between this main component opposite end, at these two ends all the hole of opening as kapillary sample stream, one end opening in this hole is other and liquid sample is introduced the tip in this hole at the be placed into liquid sample of this main component, and the other end opening in this hole is at a body surfaces place of this main component, and this body surfaces outwards stretches around the other end in this hole.Color reagent is arranged on it, comprise that positive and negative first and second 's a test paper adheres on this main component, first this body surfaces of this test paper over against this main component, thus the liquid sample that flows into this hole at this tip flows to this other end and contacts test paper along capillary liquid sample stream by capillarity.This test paper adheres on this main component at the bonding position of a plurality of spaced apart on the circumferential part of this test paper, and the gapped air that supplies circulates when liquid sample flows through capillary liquid sample stream between the adjacent two bonding positions.
According to another aspect of the present invention, one can be contained in a liquid-sample collection device of measuring on the reading device of characteristic of liquid sample comprises a main component, have in this main component one extend between this main component opposite end, at these two ends all the hole of opening as kapillary sample stream, one end opening in this hole is other and liquid sample is introduced the tip in this hole at the be placed into liquid sample of this main component, and the other end opening in this hole is at a body surfaces place of this main component, and this body surfaces outwards stretches around the other end in this hole.There is a test paper of color reagent to adhere on this other end in this hole of this main component on it.There is an axial projections of aliging with this hole of this main component in the central authorities of this test paper, thereby the liquid sample that flows into this hole at this tip flows to this other end in this hole by capillarity along capillary liquid sample stream, in this projection of this other end place liquid sample contact test paper and be inhaled into test paper.
Another aspect of the present invention relates to a test paper of the characteristic of measuring liquid sample.This test paper comprises the blood absorbing component of an absorption liquid sample body.There is color reagent also in the form of sheets on this blood absorbing component.There is the axial projections of stretching out outside this test paper plane in the central authorities of this blood absorbing component.This test paper also can have an annular projection that stretches along the outer circumference portion of test paper.
The present invention is described in detail below in conjunction with accompanying drawing.
Description of drawings
Fig. 1 is the part sectioned view of liquid-sample collection device of the present invention and reading device;
Fig. 2 is the longitudinal sectional drawing of reading device shown in Figure 1;
Fig. 3 is the amplification profile of liquid-sample collection device shown in Figure 1;
Fig. 4 is the stereographic map of the sample introducing portion of liquid-sample collection device;
Fig. 5 is the stereographic map of the sample outflow end of liquid-sample collection device of the present invention;
Fig. 6 is the vertical view and the side view of the sample introducing portion of this liquid-sample collection device;
Fig. 7 is the end-view of the sample outflow end of liquid-sample collection device;
Fig. 8 is contained in the sectional view of reading on the device for liquid-sample collection device;
Fig. 9 is the stereographic map that installs to the test paper on the liquid-sample collection device;
Figure 10 installs to vertical view on this end face of main component for test paper shown in Figure 9;
Figure 11 is the sectional view that cuts open the test paper of getting along XI-XI line among Figure 10, but not shown main component; And
Figure 12 illustrates the using method of the measuring equipment that liquid-sample collection device of the present invention is housed on it.
Embodiment
Below to collect blood sample so that the reading device of measuring feature that blood-sugar content in the blood sample is an example explanation liquid-sample collection device of the present invention and details and using with liquid-sample collection device.But, be noted that this liquid-sample collection device and read device to can be used to collect the liquid sample outside the blood, the characteristic outside the measuring blood content.
As shown in Figure 1, the present invention reads device 1 by a liquid-sample collection device or tip 5 and one and combines.As shown in Figure 1, in general, this liquid-sample collection device 5 comprises that a cylinder-shaped body spare 51 and is cemented in the test paper 53 on the end face of this main component 51.This gathering-device 5 can be used to collect the liquid sample that is absorbed by test paper 53.This gathering-device 5 also can removably be contained on the support 43 on this end of reading device 1.This reading device 1 is used for measuring the desirable characteristics (for example blood-sugar content in the blood sample) of collected liquid sample.
As shown in Figure 1, this reading device 1 comprises that one measures the measurement section 4 by the desirable characteristics of the collected liquid sample of gathering-device 5.The measurement section 4 of reading device 1 comprises an illuminating part that emits beam 41 and a light receiver member 42.This illuminating part 41 emits beam when closing the power supply of reading device 1.Because collecting has the gathering-device 5 of liquid sample to be contained on the support 43, so the irradiate light that illuminating part 41 sends is to test paper, accepted by light receiver member 42 after reflection, thereby carries out opto-electronic conversion.This signal amplifies behind 42 outputs one of light receiver member and the institute's light amount corresponding simulating signal of accepting.Then, with an A/D converter institute's amplifying signal is converted to and be input to a control device 10 backs after the digital signal according to the data computation desirable characteristics that is stored in this operating portion (for example blood-sugar content).
Gathering-device 5 preferably transparent or semitransparent (colourful transparent), and be disposable unit.Promptly after using once, promptly throw away.Main component 51 comprises a main part 513 and a tip 52.This tip 52 generally in the form of a truncated cone.This gathering-device in use, the tip 52 of main component 51 contacts with liquid sample (for example blood), the contact test paper 53 thereby liquid sample is upwards sucked in most advanced and sophisticated 52 by capillarity and absorbing by test paper 53, thereby sample spreads on test paper 53.Thereby this tip 52 of main component 51 is as the sample introducing portion of this main component.
Know clearly as Fig. 3 and to show, main component 51 comprises that one can be supported on main part 513 on the support 43 of reading device 1 to gathering-device 5.This main part 513 is around a concave region 540 of main component 51, and the bottom surface of this concave region 540 forms the part of the end face 542 of main component 51.The part formation confession test paper 53 of the end face 542 of main component adheres to the adhesion zone 512 on the main component 51.Main part 513 also comprises a bottom 511.
This main part 51 also has an annular flange flange 514 that radially outwards stretches at an end relative with most advanced and sophisticated 52.Flange 514 gathering-device 5 is installed on the support 43 of reading device 1 or when taking off as grip.Therefore, can firmly install to gathering-device 5 on this support of reading device 1 or easily from taking off this gathering-device.
The shape and size of the concave region 540 in the main part 513 match with the shape and size of the support 43 of reading device 1.Shown in Fig. 3 and 8, it is conical that the inside surface around concave region 540 of main part 513 preferably is slightly.This taper shape makes main part 513 little and big at the internal diameter on one side relative with end face 542 at end face 542 internal diameter on one side.Like this, gathering-device 5 can firmly be enclosed within on the support 43 of reading device 1, although have difference between the internal diameter of the main part 513 of the external diameter of the support 43 of reading device 1 or shape and gathering-device 5.
According to the preferred embodiment, bottom 511, main part 513 and flange 514 are made one, although they also can separately be made and be assembled together.In addition, although one is made with bottom 511 in tip 52, they also can separately be made and link together.
One hole of both ends open or passage 520 pass main component 5 to the other end from an end.This hole 520 forms kapillary sample stream and leans on capillarity liquid sample to be drawn into the concave region 540 of main part 513 from tip 52.Hole 520 is vertical with test paper 53.Hole 520 is led to most advanced and sophisticated 52 sample flow inlet 523 and is led to the concave region 540 sample flow outlet 527 on one side of main part 513.The end face 542 of main component 51 forms the body surfaces that radially outwards stretches around the sample flow outlet 527.
As mentioned above, test paper 53 is cemented on the adhesive portion 512 of end face 542 of main component 51.Circular test paper 53 shown in Fig. 9 and 10 can be by welding or bonding (for example viscose glue be bonding) and be firmly adhered on its position.Particularly, test paper 52 as shown in figure 10 on the excircle with test paper 53 the bonding position 534 of a plurality of spaced apart cement on the adhesive portion 512 of main component 51 end faces.In the time of on bonding to main component 51 like this, form one between every pair of adjacent bonding position 534 and go out gas area 544.Thereby, after test paper 53 cements on the main component 51, form between the end face 542 of main component 51 and a plurality ofly go out gas area 544 along the circumference distance.Like this, when liquid sample was inhaled in the passage 520 by capillarity in this device process of use, air can be discharged between the end face 542 of test paper 53 and main component 51 through going out gas area 544.Because fusion of test paper 53 usefulness or viscose glue firmly are bonded on the main component 51, test paper 53 can stably support or be fastened on the main component 51 and prevent the undesirable space of being caused by the distortion of test paper 53 (for example crooked, reverse, fold or the like), successfully spreads thereby be convenient to liquid sample.
As shown in Figure 3, the part of main component 51 end faces 542 is recessed and form an annular gap 54 between end face 542 and test paper.This gap 54 helps liquid sample radially outwards to flow when liquid sample arrives the flow export 527 of passage 520.Like this, liquid sample can very fast and successfully be diffused on whole the test paper by capillarity.
Be suitable for most realizing above-mentioned functions although the degree of depth in gap 54 can be made, this degree of depth is preferably between the 0.04mm-0.4mm more preferably greater than 0.02mm (mean value).In this range of size, can effectively realize the above-mentioned functions in gap 54.In addition, the degree of depth in gap 54 can remain unchanged or change.
54 outer radial periphery has an annular sample storage tank 55 in the gap.It is dark that the size of this annular sample storage tank 55 is made ratio gap 54, is communicated with gap 54 simultaneously.This sample storage tank 55 is positioned at the inner radial that test paper 53 is cemented in the adhesion zone 512 on main component 51 end faces 542.But these annular sample storage tank 55 confined liquid samples radially outwards flow.That is, outwards flow along with the liquid sample in the passage 520 arrives helping radially of flow export 527 mat gaps 54, liquid sample arrives annular sample storage tank 55 and flows in this storage tank, thereby can't radially outwards flow to storage tank 55 outsides.Like this, liquid sample can't flow into test paper 53 and be cemented in adhesion zone 512 on the main component end face 542.Liquid sample also can't radially outwards flow to test paper periphery outside through the gas area that goes out that test paper 53 is cemented between the bonding pad 544 on main component 51 end faces 542.Thereby, even outside the excessive periphery that also can not drain to test paper of collected liquid sample.Because of the liquid sample contact and stick to the end of reading device 1 and polluted, this point is very important from the end that can prevent to read device 1.
The radially outer of storage tank 55 has a spacer assembly.In one embodiment of this invention, this spacer assembly is made of the circular projection or the projection separator 56 of four spaced apart.These separators can 90 ° the interval be spaced from each other.As shown in Figure 8, these separators 56 can guarantee that end face and the test paper 53 of reading device 1 when gathering-device 5 is on installing to the support 4 of reading device 1 separate.Gathering-device 5 is on installing to the support 4 of reading device 1 time, and the end face of support 4 is against these separators 56, thereby the end face that prevents support 4 is run into the test paper 53 of absorption liquid sample body.As shown in Figure 8, the axial dimension of separator 56 is greater than the thickness of test paper 53.Separator 56 makes test paper 53 can't contact the end of reading device 1, thereby liquid sample can not adhere to the reading device and pollute the reading device.
In addition, separator 56 can keep a constant partition distance between the illuminating part 41 of test paper 53 and photometric measurer 4 and light receiver member 42.Thereby the measuring error that the optical characteristics deviation that is caused by the change of the illuminating part 41 of test paper 53 and photometric measurer 4 and the distance between the light receiver member 42 causes can be reduced to minimum degree.Thereby raising measuring accuracy.
Shown in Fig. 3-5, an end at the tip 52 of main component 51 forms a sample and flows into end 521, and the other end at the tip 52 of main component 51 forms a sample outflow end portion 525.On the free end of sample inflow end 521 groove 522 is arranged.Groove 522 and passage 520 are vertical and extend between most advanced and sophisticated 52 the outer circumference surface and passage 520.Therefore, the two ends of groove 522 are all in most advanced and sophisticated 52 outer circumference surface upper shed.
Groove 522 can impel in the liquid sample flow channel 520.As shown in figure 12, when the sample at the tip 52 that makes main component 51 in order to obtain for example blood sample flowed into end 521 contact people's finger surface, groove 522 helped to prevent that passage 520 from being stopped up, and if there is not groove 522 just may stop up.Thereby blood or other liquid samples can successfully flow on the test paper 53 through this passage.
Referring to Fig. 6, total circumference of establishing groove 522 relative passages 520 is L
1And the internal diameter (at the enter the mouth internal diameter at 523 places of sample flow) of establishing passage 522 is d
1, circumference L
1Inner periphery length overall 2d with passage 520
1Preferably satisfy following relationship formula (I):
L
1＜2d
1×50％(I)
Groove 522 and passage 520 are designed to satisfy the above-mentioned relation formula can rapidly, successfully begin aspiration sample (being that sample begins flow channel 520 by capillarity).
The degree of depth P of groove 522
1Preferably selected according to for example skin.Degree of depth P
1Generally, be preferably 0.2-1.8mm greater than 0.1mm.As degree of depth P
1Too little (being that groove 522 is too shallow), blood and so on sample just is difficult in the groove 522 and flows when then pressing too tightly on skin.
Should see that the shape of groove 522, quantity, position and other characteristics are not limited to shown in the accompanying drawing.As the sample at the tip 52 of main component 51 flows into end 521 and need not to obtain sample against skin when using gathering-device, shown in structure can add change.For example, can around the sample flow inlet 523 of passage 520, radially form a plurality of grooves 522 (for example being cruciform) or on passage 520, form a plurality of parallel grooves 522.
Shown in Fig. 3 and 8, the sample at the tip 52 of main component 51 flows out end 525 jut, this jut than the adjacent dimple that forms gap 54 vertically towards the concave region 540 of main component 51 projection slightly more.Thereby the radial inner end in gap 54 is the boundary with this jut.Test paper 53 shown in Fig. 3 and 8 against the end face of this jut.There is a circumferentially extending groove 526 that passage 520 is communicated with gap 54 on the end face of this jut.Thereby gap 54 is all led at the two ends of this groove 526.
Because this groove 526, flow through passage 520 liquid sample can from sample flow export 527 through this groove 526 to external diffusion.This helps sample to be diffused on whole the test paper 53.Thereby, liquid sample diffusion equably rapidly and, thus the characteristic that will measure can accurately be measured.
Referring to Fig. 7, the borderline phase of establishing groove 526 is L to total circumference of passage 520
2And the internal diameter (exporting the internal diameter at 527 places in sample flow) of establishing passage 520 is d
2, circumference L
2Inner periphery length overall 2d with passage 520
2Preferably satisfy following relationship formula (II):
L
2＜2d
2×50％(II)
The shape of groove 526 and position are not limited to shown in Fig. 3,7 and 8.For example, can around the sample flow outlet 527 of passage 520, form a plurality of circumferentially extending grooves 526 (for example being cruciform) or on passage 520, form a plurality of parallel grooves 526.
Using as shown in figure 12 when of the present invention, it is other that the tip 52 of this blood gathering-device is placed into due-in liquid collecting sample body (for example blood in people's the finger), thereby liquid sample is supplied with test paper 53 by capillarity by back in the suction passage 520 upwards.The internal diameter of passage 520 (mean value) is about 0.2mm-2.0mm, preferably is about 0.5mm-1.0mm.If the internal diameter of passage 520 is too big, liquid sample just is difficult to carry by capillarity.On the other hand, if the internal diameter of passage 520 is too little, the flowing velocity of liquid sample in passage 520 is just too slow, and it is just oversize that the sufficient liquid sample is offered test paper 53 required times.
The internal diameter of passage 520 or xsect can remain unchanged on the length of passage 520, but also can change.Length overall between 520 liang of openends of passage preferably is about 1mm-5mm, if it is then better to be about 2mm-4mm.
Make by rigid material by the main component 51 that tip 52 and main part 513 are formed with certain degree of hardness.This rigid material comprises acryl resin, polystyrene, tygon, polypropylene, hard polyvinylidene chloride, poly-sulfuric ester, polymethylmethacrylate, ABS resin, polyester, poly-p-phenylene sulfide (PPS), acid amides, polyimide, polyacetal, polymer alloy, polymer blend, Deng, this rigid material contains at least a above-mentioned substance.In these materials, be particularly suitable for sucking rapidly and a kind of material of diffusion liquid sample is acryl resin an and so on hydrophilic material or through the material of hydrophilic treatment.
Physically activated processing of available Cement Composite Treated by Plasma, glow discharge, corona discharge, ultraviolet radiation and so on or sprayed surface activator, water-soluble silicone, hydroxy propyl cellulose, tygon glycol, polypropylene glycol etc. carry out hydrophilic treatment.
Have on the test paper 53 and be immersed in the reagent (color reagent is arranged) that can absorb in the carrier of sample.This carrier preferably is made of the porous membrane or the flake porous medium of absorption liquid sample body.Non-weaving cloth, woven cloths, drawing sheet etc. are for example arranged.When obtaining blood sample with the present invention, the porosity of this porous membrane preferably can be crossed the red blood cell in the hemofiltration.This reagent is selected according to the characteristic or the composition (for example blood-sugar content in the blood sample) of liquid sample to be measured.
Because test paper comprises the carrier that is made of porous membrane, therefore under the situation of reagent as the reaction of the oxygen in oxydase reaction and so on medium and the atmosphere, accept face and be full of sample even thereby sample is diffused on whole the test paper 53 sample, this reaction also can be carried out rapidly owing to the oxygen from the atmosphere of detection faces supply.Because the porosity of this porous membrane can be crossed the red blood cell in the hemofiltration, so do not remove sample or its filtered composition (red blood cell etc.) also can detect painted situation.
Although the manufacturing materials of porous membrane can be materials such as polyesters, amide-type, polyalkenes, polysulfones, cellulose, but, therefore preferably use hydrophilic material or through the material of hydrophilic treatment because it is immersed in the aqueous solution that wherein is dissolved with reagent or filters haemocyte when measuring.Can carry out hydrophilic treatment by the described the same manner of above-mentioned combining main body spare.
When obtaining blood sample, be immersed in and be used for measuring the colorant (staining reagent) that for example reagent of blood-sugar content comprises glucose oxidase (GOD), peroxidase (POD) and 4-amino aminoantipyrine, N-ethyl N-(2-hydroxy-3-sulfopropyl)-m-toluidine and so in the porous membrane with this liquid-sample collection device.In addition, according to measuring composition, can comprise material and above-mentioned colorant (staining reagent) with the reaction of ascorbic acid oxidase, alcohol oxidase, cholesterol and so on blood constituent.In addition, this reagent can contain the buffering agent of phosphate buffer and so on.Should see that the kind of reagent and composition are not limited to mentioned kind and composition.
The invention still further relates to the special construction and the shape of test paper 53, its details can be seen the most clearly from Fig. 8-11.Although it is circular that the shape of test paper 53 is preferably, also can use test paper such as for example oval, square, rectangle, rhombus, triangle, hexagon, octagon.
As using circular test paper 53, the external diameter of test paper 53 is about 2mm-10mm, is preferably 4mm-7mm.The thickness of test paper 53 is about 0.02mm-1.0mm, preferably is about 0.05mm-0.4mm.
The central authorities of test paper 53 have one to reach test paper 53 out-of-plane axial protuberance or projections 531.When test paper 53 installed on the end face 542 of main component 51 shown in Fig. 3 and 8, projection 531 was to passage 520 projections.Although the axial height of projection 531 is unrestricted, the size of projection 531 is preferably made it and stretches into (being the jut that projection 531 is crossed groove 526 places of main component 51) in the passage 520, thereby is arranged in sample flow outlet 527.Therefore the height of projection 531 is about 0.02mm-1.0mm, preferably is about 0.05mm-0.4mm.
The shape of projection 531 and external dimensions preferably are equal to or less than passage 520 exports 527 places in sample flow internal diameter.The shape of projection 531, size and other characteristics are not limited to top described, preferably decide according to the shape of cross section of for example passage 520 and size.
Supply with test paper 53 from being convenient to liquid sample, projection 531 is given test paper with good characteristic.That is, because the existence of projection 531 is arranged, the liquid sample in the passage 520 is the projection 531 places contact test paper 53 in preferably stretching into sample flow outlet 527 at first, this means that liquid sample supplies with test paper 53 rapidly.
Test paper 53 also have with the axial stretching, extension annular protrusion or the projection 532 of projection 531 same direction projections.This annular projection 532 is positioned at the radially outer of central protrusion 531, the excircle of close test paper 52.Shown in Fig. 3 and 8, the end of this projection 532 is arranged in sample storage tank 55 when test paper 53 installs on the end face 542 of main component 51.
This annular projection 532 can limit liquid sample on the test paper 53 to external diffusion.Thereby prevent that the excess liq sample from outwards flowing above the excircle of these annular projection 532 arrival test paper.
There is no particular restriction for the external diameter size of annular projection 532, but be preferably the 60%-95% of the external diameter of test paper 53, if the 70%-90% of the external diameter of test paper 53 is then better.
The width of annular projection 532 is about 0.03mm-1.0mm, preferably is about 0.05mm-0.5mm.The height of annular projection 532 is about 0.02mm-1.0mm, preferably is about 0.05mm-0.4mm.
The shape and size of annular projection 532 (for example external diameter, width, height etc.) are decided by shape and other characteristics of main component 51.
Hemispherical projections 531 and annular projection 532 are made in available mold pressing processing (for example using the bottom of punch ram test paper 53) or shearing.
Shown in Fig. 9-11, a department of assembly 533 as test paper and main component adhesion zone is arranged on the excircle of test paper 53.This department of assembly 533 is positioned at the radially outer of annular projection 532.As mentioned above, test paper 53 is on these department of assembly's 533 usefulness weldings or the bonding adhesive portion 512 that is cemented in main component 51.
Figure 12 illustrates a kind of application of sample collection device of the present invention, promptly is used for collecting blood sample.As shown in figure 12, for example use other parts of finger or the health of piercing through the people with one single needle, thereby a spot of blood (for example 2-6 μ l) 18 flows to skin surface.
Make sample on the tip 52 of this gathering-device 5 flow into the end face contact of end 521 after sample collection device 5 being installed on the support 43 of the photo measure portion 4 of reading device 1 or near skin.Blood 18 on the finger flows to test paper 53 by capillarity along passage 520 after groove 522 arrives sample flow inlet 523.Because blood 18 is by effectively from the opening edge suction passage 520 of groove 522, therefore the end face at the tip 52 of main component 51 against or blood can diffusion everywhere on skin during near skin.
Thereby projection 531 parts that flow to the blood contact test paper 53 of sample flow outlet 527 through passage 520 are absorbed by test paper 53, and a part flows radially outward in the body surfaces upper edge that the end face 542 by main component 51 defines through groove 526.The blood that outwards flow from groove 526 arrive gaps 54 back parts and 54 are absorbed by test paper 53 in the gap, and another part radially outwards flows to the excircle of test paper 53.Be used for blood by test paper 53 absorb and spread, therefore particularly blood is absorbed by test paper at projection 531 places, produce a suction in passage 520, thereby blood continues to be attracted to test paper 53.
Therefore, under the sample collection device of doing according to structure of the present invention, if the negligible amounts of the blood 18 of sample to be collected, blood still can offer test paper 53 not lavishly.On the other hand, if the quantity of the blood 18 of sample to be collected is a lot, thereby the blood that offers test paper 53 is excessive, and then excessive blood can be deposited in the sample storage tank 55, thereby blood can't outwards flow out outside the excircle of test paper 53.Annular projection 532 on the test paper 53 prevents that also blood flow from going out outside the excircle of test paper 53.Therefore, blood can't outwards drain to outside the edge of test paper 53 and pollute the end face 542 of main component 51, thereby guarantees that photo measure portion 4 and peripheral part of reading device 1 can not polluted because of the adhesion of blood.Therefore, reading device its measurement result when using thereafter can not affect adversely.In addition, when throwing away used sample collection device, can reduce pollution, thereby improve security the medical worker.
In a single day blood be diffused on whole the test paper 53, the reagent reacting on the target component in the blood (for example glucose) and the test paper 53, thus a color is shown according to the quantity of target component.Can determine the quantity (for example blood-sugar content) of the target component in the blood with the intensity of color shown in the said method measurement.Be trapped within the gap 54 owing to red blood cell in the blood etc. filters, so they can not influence the measurement to color shown on the test paper 53.
As mentioned above, when using gathering-device 5 of the present invention, no matter the quantity of the blood 18 on the skin is how, by simple operations just can make blood flow to and be diffused on whole the test paper 53.Therefore, can not produce measuring error, thereby measuring accuracy improves.In addition, because the relation of the collection of liquid sample and people's operant level becomes not quite, so reduce or eliminate by the error that people's misoperation causes.
Sample collection device of the present invention not only can be used to collect blood sample, also can be used to collect other liquid samples, for example urine, lymph liquid, celiolymph, saliva and other body fluid or its dilution and concentrate.
In addition, composition to be measured can be inorganic ions, haemoglobin of albuminoid, cholesterol, uric acid, kreatinin, ethanol, sodium and so on or the like in the sample.
According to the present invention, no matter the type of sample and quantity, assembling position or collection method are how, the reading device that this sample collection device and this device are installed on it can be used to collect more rapidly, reliably required sample, can obtain accurate measurement result simultaneously.
In addition, this sample collection device is easy to operate, particularly can install to this tip on this reading device and from taking off easily.Owing to can make things convenient for, on the reading device, load onto or unload sample collection device reliably, therefore can avoid by reading the deviation of assembling improper measuring error that causes of gathering-device and measurement result on the device.
In addition, can avoid owing to the part sample adhesion is being read the pollution that causes the reading device on the device, thereby improve security.
Above instructions has illustrated principle of the present invention, preferred embodiment and mode of operation.But claimed the present invention should not regard as and be limited to described specific embodiments.In addition, the foregoing description should regard exemplary and nonrestrictive as.In spirit of the present invention, can make all changes and use suitable thing.Therefore, this class change of all of making within the spirit and scope of the present invention and suitable thing all should be regarded as and be included in the present invention.
Claims (6)
1, a kind of liquid-sample collection device, this device can be contained in one and measure on the reading device of characteristic of liquid sample, and this liquid-sample collection device comprises:
One main component, have one to extend between this main component opposite end in this main component, all the hole of opening is used as kapillary sample stream at these two ends, one end opening in this hole is other and liquid sample is introduced the most advanced and sophisticated place in this hole at the be placed into liquid sample of this main component, and the other end opening in this hole is at a body surfaces place of this main component, this body surfaces is in the outwards stretching, extension all around of the other end in this hole, this main component tip has end surfaces and outer circumference surface, has at least one groove to extend between the hole of most advanced and sophisticated outer circumference surface and main component on the end surfaces at this main component tip; And
Test paper, this test paper comprises the blood absorbent portion that is used for the absorption liquid sample body and has positive and negative first and second, this test paper is fixed on the main component, make first this body surfaces of this test paper, thereby the liquid sample that flows into this hole at this place, tip flows to this other end and contacts this test paper along capillary liquid sample stream by capillarity over against this main component.
2, by the described liquid-sample collection device of claim 1, it is characterized in that, test paper a plurality of isolated bonding positions on the test paper circumferential part cement on the main component, gapped between the adjacent bonding position, thus air can flow in these gaps when liquid sample flows in capillary liquid sample stream.
3, by the described liquid-sample collection device of claim 1, it is characterized in that this test paper is the sheet that is arranged in a plane, described test paper central authorities are provided with and reach the described out-of-plane projection that extends axially.
4, by the described liquid-sample collection device of claim 1, it is characterized in that, this test paper is the sheet that is arranged in a plane, this test paper comprises that a ring shaped axial that extends on the outer circumference portion of this test paper stretches projection, and described annular projection stretches out outside this plane of this test paper with the direction towards this body surfaces of this main component.
5, by the described liquid-sample collection device of claim 1, it is characterized in that, described liquid-sample collection device comprises at least one projection, this at least one projection is from this body surfaces upper edge axial projections and be positioned at the radially outer in this hole, is used for making when this gathering-device installs on this reading device end face and the test paper of reading device to separate.
6, by the described liquid-sample collection device of claim 1, it is characterized in that described main component has a dimple that inserts for an end of reading device, described dimple has a bottom surface of being defined by this body surfaces.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP05656097A JP3699799B2 (en) | 1997-03-11 | 1997-03-11 | Blood test tool |
| JP56560/1997 | 1997-03-11 | ||
| JP85985/1997 | 1997-03-19 | ||
| JP8598597 | 1997-03-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97126136A Division CN1104635C (en) | 1997-03-11 | 1997-12-31 | Liquid-sample collection device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1447104A CN1447104A (en) | 2003-10-08 |
| CN1208609C true CN1208609C (en) | 2005-06-29 |
Family
ID=26397515
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97126136A Expired - Lifetime CN1104635C (en) | 1997-03-11 | 1997-12-31 | Liquid-sample collection device |
| CNB021261113A Expired - Fee Related CN1208609C (en) | 1997-03-11 | 2002-07-15 | Liquid sample collector |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97126136A Expired - Lifetime CN1104635C (en) | 1997-03-11 | 1997-12-31 | Liquid-sample collection device |
Country Status (4)
| Country | Link |
|---|---|
| KR (1) | KR100244016B1 (en) |
| CN (2) | CN1104635C (en) |
| SG (2) | SG106594A1 (en) |
| TW (1) | TWI230790B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101073595B (en) * | 2007-06-18 | 2011-07-20 | 石任兵 | Glycyrrhiza total flavonoid and total saponin extract and its production |
| CN101266243B (en) * | 2008-01-31 | 2012-09-19 | 程柯 | Instrument for collecting and rapidly detecting oral liquid |
| CN102141566B (en) * | 2010-02-03 | 2014-09-10 | 艾博生物医药(杭州)有限公司 | Device for collecting fluid samples |
| EP2777499B1 (en) * | 2013-03-15 | 2015-09-16 | Ortho-Clinical Diagnostics Inc | Rotatable fluid sample collection device |
| CN104749169B (en) * | 2013-12-31 | 2018-04-20 | 比亚迪股份有限公司 | Blood sugar detection apparatus and blood sugar test kit |
| US9480981B2 (en) * | 2014-07-25 | 2016-11-01 | General Electric Company | Sample collection and transfer device |
| US9901922B2 (en) * | 2014-07-25 | 2018-02-27 | General Electric Company | Sample collection and transfer device |
| FR3038387B1 (en) * | 2015-07-03 | 2017-07-07 | Avalun | ANALYSIS SYSTEM OF A LIQUID SAMPLE |
| ES2848384T3 (en) * | 2015-08-12 | 2021-08-09 | The Univ Of Tasmania | Liquid collection device |
| CN106198950A (en) * | 2016-07-08 | 2016-12-07 | 艾康生物技术(杭州)有限公司 | For depositing paper box and the sample testing apparatus of Test paper |
| CA3067339C (en) * | 2017-08-02 | 2022-06-07 | F. Hoffmann-La Roche Ag | Glucose test arrangement and method |
| CN107807006A (en) * | 2017-10-25 | 2018-03-16 | 上海菲伽生物科技有限公司 | Storage civilian dress for detection of defecating is put |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4627445A (en) * | 1985-04-08 | 1986-12-09 | Garid, Inc. | Glucose medical monitoring system |
| US5100620A (en) * | 1989-05-15 | 1992-03-31 | Miles, Inc. | Capillary tube/gap reagent format |
| US5565170A (en) * | 1990-08-30 | 1996-10-15 | Kyoto Daiichi Kagaku Co., Ltd. | Multilayer analytical element for assaying fructosamine |
| JPH06500174A (en) * | 1990-10-30 | 1994-01-06 | ハイポガード（ユーケイ）リミテッド | Collection and display equipment |
| DE4217733A1 (en) * | 1992-05-29 | 1993-12-02 | Boehringer Mannheim Gmbh | Test carrier for analyte determination and method for its production |
-
1997
- 1997-12-29 SG SG200006778A patent/SG106594A1/en unknown
- 1997-12-29 SG SG9704709A patent/SG79957A1/en unknown
- 1997-12-31 KR KR1019970081241A patent/KR100244016B1/en not_active IP Right Cessation
- 1997-12-31 TW TW086120074A patent/TWI230790B/en not_active IP Right Cessation
- 1997-12-31 CN CN97126136A patent/CN1104635C/en not_active Expired - Lifetime
-
2002
- 2002-07-15 CN CNB021261113A patent/CN1208609C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1447104A (en) | 2003-10-08 |
| CN1104635C (en) | 2003-04-02 |
| SG79957A1 (en) | 2001-04-17 |
| CN1193106A (en) | 1998-09-16 |
| KR100244016B1 (en) | 2000-02-01 |
| SG106594A1 (en) | 2004-10-29 |
| TWI230790B (en) | 2005-04-11 |
| KR19980079571A (en) | 1998-11-25 |
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