CN1208604A - Composition for use in oral cavity - Google Patents
Composition for use in oral cavity Download PDFInfo
- Publication number
- CN1208604A CN1208604A CN 98116861 CN98116861A CN1208604A CN 1208604 A CN1208604 A CN 1208604A CN 98116861 CN98116861 CN 98116861 CN 98116861 A CN98116861 A CN 98116861A CN 1208604 A CN1208604 A CN 1208604A
- Authority
- CN
- China
- Prior art keywords
- composition
- oral cavity
- record
- calcium
- supplying compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 43
- 210000000214 mouth Anatomy 0.000 title claims abstract description 36
- 150000001875 compounds Chemical class 0.000 claims abstract description 22
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract description 19
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 150000005846 sugar alcohols Chemical class 0.000 claims abstract description 17
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 12
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000811 xylitol Substances 0.000 claims abstract description 10
- 235000010447 xylitol Nutrition 0.000 claims abstract description 10
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 10
- 229960002675 xylitol Drugs 0.000 claims abstract description 10
- 230000002308 calcification Effects 0.000 claims description 22
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 17
- 239000000606 toothpaste Substances 0.000 claims description 15
- 229940034610 toothpaste Drugs 0.000 claims description 15
- 229910019142 PO4 Inorganic materials 0.000 claims description 14
- 239000010452 phosphate Substances 0.000 claims description 14
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 13
- 239000011575 calcium Substances 0.000 claims description 10
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 10
- 239000000377 silicon dioxide Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 8
- 238000000227 grinding Methods 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 5
- 229910052799 carbon Inorganic materials 0.000 claims description 5
- 239000011775 sodium fluoride Substances 0.000 claims description 5
- 235000013024 sodium fluoride Nutrition 0.000 claims description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 4
- 229960005069 calcium Drugs 0.000 claims description 4
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 4
- 239000001527 calcium lactate Substances 0.000 claims description 4
- 235000011086 calcium lactate Nutrition 0.000 claims description 4
- 229960002401 calcium lactate Drugs 0.000 claims description 4
- 229910052731 fluorine Inorganic materials 0.000 claims description 4
- 239000011737 fluorine Substances 0.000 claims description 4
- 150000001669 calcium Chemical class 0.000 claims description 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 14
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 abstract description 12
- 229910001634 calcium fluoride Inorganic materials 0.000 abstract description 12
- 238000001556 precipitation Methods 0.000 abstract description 8
- 239000003945 anionic surfactant Substances 0.000 abstract description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 abstract 2
- 230000000903 blocking effect Effects 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 15
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 14
- -1 phosphate anion Chemical class 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 206010025421 Macule Diseases 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- 230000001680 brushing effect Effects 0.000 description 4
- 208000002925 dental caries Diseases 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
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- 235000012239 silicon dioxide Nutrition 0.000 description 4
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- 208000006558 Dental Calculus Diseases 0.000 description 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 159000000007 calcium salts Chemical class 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 238000005530 etching Methods 0.000 description 3
- 159000000003 magnesium salts Chemical class 0.000 description 3
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- 238000000034 method Methods 0.000 description 3
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
- KLZUFWVZNOTSEM-UHFFFAOYSA-K Aluminium flouride Chemical compound F[Al](F)F KLZUFWVZNOTSEM-UHFFFAOYSA-K 0.000 description 2
- 239000000120 Artificial Saliva Substances 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 239000007995 HEPES buffer Substances 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 241000194019 Streptococcus mutans Species 0.000 description 2
- 230000009102 absorption Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 150000007942 carboxylates Chemical class 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 210000003298 dental enamel Anatomy 0.000 description 2
- 239000000551 dentifrice Substances 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 229960003511 macrogol Drugs 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical group [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000005086 tooth mineralization Effects 0.000 description 2
- 150000003732 xanthenes Chemical class 0.000 description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- QGLWBTPVKHMVHM-KTKRTIGZSA-N (z)-octadec-9-en-1-amine Chemical compound CCCCCCCC\C=C/CCCCCCCCN QGLWBTPVKHMVHM-KTKRTIGZSA-N 0.000 description 1
- BMVXCPBXGZKUPN-UHFFFAOYSA-N 1-hexanamine Chemical compound CCCCCCN BMVXCPBXGZKUPN-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- DBTMGCOVALSLOR-UHFFFAOYSA-N 32-alpha-galactosyl-3-alpha-galactosyl-galactose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(OC2C(C(CO)OC(O)C2O)O)OC(CO)C1O DBTMGCOVALSLOR-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
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- 230000014759 maintenance of location Effects 0.000 description 1
- UYQJCPNSAVWAFU-UHFFFAOYSA-N malto-tetraose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(O)C(CO)O2)O)C(CO)O1 UYQJCPNSAVWAFU-UHFFFAOYSA-N 0.000 description 1
- LUEWUZLMQUOBSB-OUBHKODOSA-N maltotetraose Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O[C@@H]3[C@@H](O[C@@H](O)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-OUBHKODOSA-N 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- FYGDTMLNYKFZSV-UHFFFAOYSA-N mannotriose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(O)C(O)C2O)CO)C(O)C1O FYGDTMLNYKFZSV-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- MWKFXSUHUHTGQN-UHFFFAOYSA-N n-decyl alcohol Natural products CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- REYHXKZHIMGNSE-UHFFFAOYSA-M silver monofluoride Chemical compound [F-].[Ag+] REYHXKZHIMGNSE-UHFFFAOYSA-M 0.000 description 1
- 150000003385 sodium Chemical class 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The present invention relates to a composition for the oral cavity, which comprises a compound serving as a fluorine ion supplier, a compound serving as a calcium ion supplier, and a sugaralcohol in which xylitol is contained in a proportion of not less than 1/2 by weight. This composition is capable of blocking the potential precipitation of calcium fluoride between calcium ion and fluorine ion even when anionic surfactant is present, and has a highly excellent effect of accelerating re-calcification of the teeth.
Description
The present invention relates to a kind of composition for oral cavity, relate in more detail a kind of have promote the tooth effect, the composition for oral cavity of excellent in stability of calcification again.
The main constituent of dentine is hydroxyapatite (Ca
10(PO
4)
6(OH
2) phosphate anion or the stripping (deviating from) of calcium ion and the crystallization (calcification again) of calcium phosphate or hydroxyapatite are in poised state usually in the oral cavity.The acid that the pathogenic bacterium of known dental caries produce promotes deliming.That is to say that dental caries is to produce like this, constitute the organic acid of the Streptococcus mutans generations such as bacterial decomposition sucrose such as (streptococcus mutans) of tartar, pH is reduced, make strippings such as calcium based on lactic acid.But, at the initial stage of dental caries, on the enamel of normally transparent, produce white macula (white spot), but, white macula is disappeared by promoting calcification again with fluorion or calcium ion, make enamel transparence again.
If but make fluorion and calcium ion coexistence, then generate the precipitation of calcium fluoride, the facilitation effect of calcification reduces again.For addressing the above problem, having developed 2 doses is dental care product (spy opens clear 52-61236 communique, and the spy opens clear 58-219107 communique), and this goods are that the calcium ion aqueous solution is separately preserved with different containers with the fluorion aqueous solution, suitably mix during use.A kind of promotion that utilizes sugar phosphate etc. to make calcium fluoride be dispersed into colloidal and make composition for oral cavity of calcification (spy opens flat 3-72415 communique) has more also been proposed in addition.
But the spy opens clear 52-61236 communique, the spy opens disclosed method in the clear 58-219107 communique, and its manufacturing process is numerous and diverse, and must mix 2 kinds of liquid, existing problems aspect simplicity when using.In addition; the technology of Te Kaiping 3-72415 communique is difficult to disperse the calcium fluoride of higher concentration to become colloidal; if there are anion surfactants such as the alkyl sulfate salt generally be usually used in the toothpaste, N-acylamino acid, can reduce the dispersion effect of above-mentioned sugar phosphate.
Therefore the object of the present invention is to provide a kind of composition for oral cavity that promotes the tooth calcification, said composition can suppress to generate the precipitation of calcium fluoride by fluorion and calcium ion.
Discoveries such as the inventor, except that cooperating fluorion supplying compound and calcium ion supplying compound, if cooperate the sugar alcohols that contains xylitol, be surprisingly found out that then the precipitation that can suppress calcium fluoride generates, thereby obtain the good composition for oral cavity of tooth calcification facilitation effect again, so far finished the present invention.
That is to say, the invention provides a kind of composition for oral cavity, it is characterized in that containing fluorion supplying compound, calcium ion supplying compound and sugar alcohol, wherein content of sugar alcohol is (weight ratio) more than 1/2.
Any that to be used for fluorion supplying compound of the present invention can be inorganic compound, organic compound.Specifically can enumerate sodium fluoride, potassium fluoride, stannic fluoride, fluoridize sodium silicate, sodium monofluorophosphate, aluminium fluoride, Argentous fluoride, etching acid hexylamine, etching acid decanol amine, etching acid oleyl amine etc.Wherein consider special preferred fluorinated sodium from aspects such as safety, dissolubility, local flavors.The use level of the fluorion supplying compound in the composition for oral cavity is scaled 0.002～1 weight % by fluorine element, preferred especially 0.01～0.2 weight %.By being controlled at 0.002～1 weight %, can not causing harmful effect, and can further promote calcification again the local flavor and the rerum natura of composition for oral cavity.
Content (being converted into calcium) (Ca/F, weight ratio) with respect to the calcium ion supplying compound of the content (being converted into fluorine) of fluorion supplying compound is below 1/2, preferred especially 1/100～1/3.As be lower than 1/2, then the precipitation of calcium fluoride generates and is suppressed, and further promotes calcification again.
Sugar alcohol is to have the material that promotes calcification effect again when the precipitation that suppresses calcium fluoride generates.Sugar alcohol for example can be enumerated lactose, hydroxyl isomaltulose, maltotriose alcohol, Isomaltotriose alcohol, the different maltotetraose alcohol of handkerchief Buddhist nun alcohol (パ ニ ト-Le), erithritol, arabitol, ribitol, xylitol, Sorbitol, mannitol, maltose alcohol etc.This sugar alcohol can be D body or L body, or the mixture of D body and L body.Wherein xylitol not only has the dental caries cause of disease bacterium propagation that suppresses in the tartar, the effect that suppresses tartar pH reduction, and the effect that the precipitation of inhibition calcium fluoride generates is also very good.Therefore, among the present invention, the xylitol content (weight ratio) in the sugar alcohol is preferably more than 1/2, and is preferred especially more than 2/3.In addition, the sugar alcohol that cooperates in the present composition (Gu shape branch) total amount is 12～99 weight %, preferred especially 15～70 weight %.
Composition for oral cavity of the present invention can be a water-free Powdered or aqueous paste or aqueous.When moisture, the content of water does not have special restriction, is preferably 1～90 weight %.Under the aqueous situation, sugar alcohol is preferably more than the 25 weight % with respect to the content of water, is preferably 35～300 weight % especially.Is more than the 25 weight % as sugar alcohol with respect to the content of water, and the precipitation that then can suppress calcium fluoride generates, and can also further improve the wettability of composition for oral cavity.
Composition for oral cavity of the present invention, in the presence of sugar alcohol (particularly xylitol), the calcium fluoride that is generated by fluorion and calcium ion becomes colloidal, therefore becomes stable.
Can also contain general commonly used anion surfactant in the composition for oral cavity of the present invention, as N-acyl amino hydrochlorates such as alkyl sulfate salt such as sodium lauryl sulfate, N-acyl sarcosinates etc.Particularly when the content (weight ratio) of the sodium lauryl sulfate in the anion surfactant be 1/2 when above, can not damage effect of the present invention.
In addition, if when in composition for oral cavity of the present invention, not containing ethylenediaminetetraacetic acid (EDTA), N-(2-ethoxy)-calcium ions such as imido-acetic acid and blocking agent (chelating agen), promoting tooth comparatively desirable aspect the calcification again.
Can cooperate grinding agent in the composition for oral cavity of the present invention, grinding agent can use abrasive silica, but does not preferably use calcium class grinding agent.Have the sensation of chuckleing when usually brushing teeth with the grinding agent that is combined with abrasive silica and oxonium ion supplying compound, although but toothpaste agent of the present invention contain abrasive silica and fluorion supplying compound the two, do not have above-mentioned the sensation of chuckleing.
It is that the mean diameter of 80～200ml/100g is the material of 2～20 μ m that the abrasive silica that is used for the present invention for example can be enumerated oil absorptions such as anhydrous silicic acid, moisture silicic acid (according to the method for JIS K5101, down with).The use level of this abrasive silica in toothpaste is 5～30 weight %, is preferably 10～20 weight % especially.If use level is 5～30 weight %, then can give full play to grinding effect.In addition, for making the good shape retention of paste, the oil absorption of preferred use 2～15 weight % is the tackifying silicon dioxide of 200～400ml/100g among the present invention.
Among the present invention,, then can further promote the calcification again of tooth, can invest the tooth smooth feeling simultaneously if further cooperate carbon number 10～20, preferred 12～16 phosphate monoester or its salt.Said phosphate monoester is meant the material by following general formula (1) expression,
R in the formula
1The alkyl or the alkenyl of the straight or branched of expression carbon number 6～20, l is 0～4 integer.
Can enumerate sodium salt, potassium salt, calcium salt, magnesium salt etc. as its salt.In addition, calcium salt, magnesium salt can be the salt that the phosphate monoester by calcium ion etc. and 1 molecule forms, and also can be the salt that the phosphate monoester with 2 molecules is cross-linked to form.The salt of phosphate monoester for example can be mixed and generation easily by sodium hydroxide, calcium hydroxide etc. and phosphate monoester.Therefore, under the situation of the salt that cooperates phosphate monoester, also can cooperate phosphate monoester and sodium hydroxide etc., in the toothpaste agent, generate the salt of phosphate monoester.
Among the present invention by further cooperating carbon number 10～20, preferred 12～16 straight or branched carboxylic acid or its salt, can relax back the sensation of chuckleing of brushing teeth.As this carboxylic acid, can enumerate lauric acid, Palmic acid, stearic acid, oleic acid, linoleic acid etc.Salt as this carboxylic acid can be enumerated sodium salt, potassium salt, calcium salt, magnesium salt etc.Carboxylate can easily generate by sodium hydroxide, potassium hydroxide etc. are mixed with carboxylic acid.Therefore, cooperating under the situation of carboxylate, can cooperate carboxylic acid and sodium hydroxide etc. and in the toothpaste agent, generate the salt of carboxylic acid.
In the present invention, in the scope of not damaging effect of the present invention, can cooperate wetting agent such as glycerol, Polyethylene Glycol, binding agent such as sodium carboxymethyl cellulose, tragakanta, sweeting agents such as saccharin sodium, coloring agent, preservative agent such as methyl parahydroxybenzoate, benzoic acid, antibacterial such as benzethonium chloride, isopropyl methyl phenol, antiinflammatory, spice etc.
But, cooperate calcium carbonate or calcium class grinding agents such as calcium hydrogen phosphate, calcium pyrophosphate can make the fluorion inactivation, hinder calcification facilitation effect again, therefore undesirable.
Composition for oral cavity of the present invention can utilize well-established law to stir or mix mentioned component and make.Composition for oral cavity of the present invention can be used as dentifrice, lubricant nature toothpaste, practices uses such as property toothpaste, aqueous toothpaste, collutory.
Embodiment
Below provide embodiment and describe the present invention in detail, the present invention is not subjected to the qualification of these embodiment.
Embodiment 1～2, comparative example 1～5
Make composition for oral cavity (collutory) by the proportioning that table 1 provides, carry out following test.
7 Dens Bovis seu Bubali are cut into 2 half, behind the mirror ultrafinish surface, except the disposal face of 5mm * 5mm, apply remainder, supply with test with oiliness Ma Nikeer (マ ニ キ ユ ア).37 ℃ flooded 5 days down in the lactic acid buffer (pH4.5) of HEC tackify, made to form deliming under the top layer.Be cut in the section of 2 half Dens Bovis seu Bubali one group as calcification processing group again, another group is group (only carrying out decalcification handles) in contrast, carries out following calcification again for calcification processing group again and disposes.That is, 5 minutes collutory is disposed after washing, at 37 ℃ artificial salivas (pH7.0,20mM HEPES buffer+CaCl
2The 1.5mM Ca of origin
2++ K
2HPO
4The 0.9mMPO of origin
4 3-Solution) in the dipping about 8 hours.Washing then, washing again after collutory was disposed in 5 minutes is carried out about 16 hours calcification more again and is disposed.After this a series of disposal carried out 10 times (10 days), with ethanol and acetone dewater, drying.With mylar embedding calcification processing group and matched group again, cut into the grinding section of thick about 100 μ m afterwards, carry out soft X line and take a picture.The softer X skiagram of calcification processing group, matched group is carried out image analysis, calculates calcification rate again.The result provides in table 1.Preserved 1 day under the room temperature of the composition for oral cavity that provides in the table 1 (collutory) modulation back, observe deliquescent character.Dissolubility is with following symbolic representation: transparent zero, muddy *, the result provides in table 1.Utilize laser light scattering to observe in addition, confirm in embodiment 1 and 2, to have the colloidal particle that is considered to calcium fluoride, in comparative example, do not exist.
Table 1
* the composition of artificial saliva: 20mM HEPES buffer+1.5mMCaCl
2+ 0.9mM K
2HPO
4(pH7.0)
| Cooperation ratio (weight %) | Embodiment 1 | Embodiment 2 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 |
| Sodium fluoride calcium lactate xylitol D-sorbite glucose 1 sodium phosphate NaLS spices pure water artificial saliva * | ????0.21 ????0.1 ????25 ????- ????- ????0.1 ????0.05 ????74.54 ????- | ????0.21 ????0.1 ????15 ????15 ????- ????0.1 ????0.05 ????69.54 ????- | ????0.21 ????0.1 ????- ????- ????- ????0.1 ????0.05 ????99.54 ????- | ????0.21 ????0.1 ????- ????- ????10 ????0.1 ????0.05 ????89.54 ????- | ????0.21 1????- ????- ????- ????- ????0.1 ????0.05 ????99.64 ????- | ????- ????0.1 ????25 ????- ????- ????0.1 ????0.05 ????84.54 ????- | ????- ????- ????- ????- ????- ????- ????100 |
| Amount to | ????100 | ????100 | ????100 | ????100 | ????100 | ????100 | ????100 |
| Dissolubility is calcification rate (%) again | ????○ ????????70 | ????○ ????????65 | ????× ????????22 | ????× ????????25 | ????○ ????????33 | ????○ ????????19 | ????○ ????????17 |
Can confirm to contain the again calcification rate height of the embodiment 1～2 of sodium fluoride, calcium lactate and sugar alcohol by the result than comparative example 1～5.
The comparative example 6 of embodiment 3～5
By the proportioning that table 2 provides, in embodiment 4, modulate dentifrice, property toothpaste is practiced in modulation in other embodiment and the comparative example, and the nipper to maxillary has 5 of the experimenters with white macula of decalcification symptom to use 1 month respectively.The result is, there is the tendency of dwindling at the white macula position among the embodiment 3～5, and particularly the effect of embodiment 3,4 is obvious.And can't see variation in the comparative example 6 fully.
Table 2
| Cooperation ratio (weight %) | Embodiment 3 | Embodiment 4 | Embodiment 5 | Comparative example 6 |
| Sodium fluoride sodium monofluorophosphate calcium lactate calcium chloride xylitol D-sorbite glycerine tragcanth xanthenes glue sodium carboxymethylcellulose silicic acid anhydride Macrogol 600 methyl p-hydroxybenzoate NaLS spices pure water | 0.21-0.1-25 5-0.5 0.3 0.3 26 5 0.1 1.4 1 is an amount of | ????0.21 ????- ????0.05 ????- ????40 ????21.84 ????- ????- ????0.2 ????- ????30 ????5 ????0.1 ????1.6 ????1 ????- | -0.7-0.1 20--0.5 0.5 0.7 22 7 0.1 1.2 1 is an amount of | -0.7---4 26 0.5-0.7 22 7 0.1 1.2 1 is an amount of |
| Amount to | ????100 | ????100 | ????100 | ????100 |
| Ca content/F content (weight %) | ????1/7.3 | ????1/14.6 | ????1/2.6 | ????0 |
| The number that tooth white macula position dwindles | ????4/5 | ????3/5 | ????2/5 | ????0/5 |
Embodiment 6～9, comparative example 7
The proportion raw material that table 3 provides is added in the pure water, stir and make the toothpaste agent, carry out following test.
Use the above-mentioned toothpaste agent that obtains, respectively brushed teeth 5 minutes for 2 times sooner or later every day, the tooth thoughts and feelings after brushing teeth by following metewand evaluation by the evaluation group that 10 people form.Table 3 provides the meansigma methods that 10 people estimate.
The metewand of tooth thoughts and feelings:
2: smooth feeling is arranged
1: smooth feeling is arranged slightly
0: numbness
-1: the sense of chuckleing is arranged slightly
-2: the sensation of chuckleing is arranged
Table 3
| Cooperation ratio (weight %) | Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 | Comparative example 7 |
| Sodium fluoride * calcium lactate * * xylitol D-sorbite tragcanth xanthenes glue sodium carboxymethylcellulose abrasive silica tackifying silica Macrogol 600 NaLS methyl p-hydroxybenzoate Tetradecyl dihydrogen phosphate lauric acid stearic acid calcium 48% caustic lye of soda spices pure water | ????0.21 ????0.1 ????25 ????5 ????0.5 ????0.3 ????0.3 ????18 ????8 ????5 ????1.4 ????0.1 ????- ????- ????- ????- ????1 ????35.09 | ????0.21 ????0.1 ????25 ????5 ????- ????0.5 ????0.4 ????18 ????8 ????5 ????1.4 ????0.1 ????0.4 ????- ????- ????0.1 ????1 ????34.79 | ????0.21 ????0.1 ????25 ????5 ????- ????0.5 ????0.4 ????18 ????8 ????5 ????1.4 ????0.1 ????- ????0.2 ????- ????0.05 ????1 ????35.04 | ????0.21 ????0.1 ????25 ????5 ????- ????0.5 ????0.4 ????18 ????8 ????5 ????1.4 ????0.1 ????- ????- ????1 ????- ????1 ????34.29 | ????0.21 ????- ????25 ????5 ????- ????0.5 ????0.4 ????18 ????8 ????5 ????1.4 ????0.1 ????- ????- ????- ????- ????1 ????35.39 |
| Amount to | ????100 | ????100 | ????100 | ????100 | ????100 |
| Tooth thoughts and feelings after brushing teeth | ????0.3 | ????1.5 | ????1.1 | ????0.8 | ????-1.7 |
*: sodium fluoride 0.21%=fluorine conversion amount 0.095%
*: calcium lactate 0.1%=calcium conversion amount 0.013%
As shown in Table 3, the toothpaste agent of embodiment 6～9 is better than the toothpaste agent of comparative example 7 thoughts and feelings, and effect is remarkable when having confirmed to contain the phosphate monoester, carboxylic acid of certain chain lengths or its salt.
Composition for oral cavity of the present invention has the good promotion tooth effect of calcification again, and usability and hobby property aspect are all good when making the toothpaste agent.
Claims (12)
1. composition for oral cavity is characterized in that containing fluorion supplying compound, calcium ion supplying compound and sugar alcohol, sugar alcohol more than 1/2 (weight ratio) be xylitol.
In the claim 1 record composition for oral cavity, wherein the content of fluorion supplying compound (being converted into fluorine) is 0.002～1 weight %, the content of calcium ion supplying compound (being converted into calcium) is 0.001～0.5 weight %, the content of sugar alcohol is 12～99 weight %, calcium ion supplying compound content (Ca/F, weight ratio) with respect to fluorion supplying compound content is below 1/2.
In the claim 2 record composition for oral cavity, wherein the calcium ion supplying compound content (Ca/F, weight ratio) with respect to fluorion supplying compound content is 1/100～1/3.
4. the composition for oral cavity of each record in the claim 1～3 does not wherein contain calcium ion and blocks agent.
5. the composition for oral cavity of each record in the claim 1～4 wherein also contains water.
In the claim 5 record composition for oral cavity, wherein sugar alcohol is more than the 25 weight % with respect to the content of water.
7. the composition for oral cavity of each record in the claim 1～6 wherein also contains abrasive silica, and does not contain calcium class grinding agent in fact.
8. the composition for oral cavity of each record in the claim 1～7 wherein also contains phosphate monoester or its salt of carbon number 10～20.
9. the composition for oral cavity of each record in the claim 1～8 wherein also contains carboxylic acid or its salt of carbon number 10～20.
10. the composition for oral cavity of each record in the claim 1～9, wherein the fluorion supplying compound is a sodium fluoride, the calcium ion supplying compound is a calcium lactate.
11. the composition for oral cavity of each record in the claim 1～10 is to be used to promote the tooth composition for oral cavity of calcification again.
12. the composition for oral cavity of each record in the claim 1～11 is the toothpaste agent.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP209011/97 | 1997-08-04 | ||
| JP209010/97 | 1997-08-04 | ||
| JP209011/1997 | 1997-08-04 | ||
| JP20901097 | 1997-08-04 | ||
| JP09209011A JP3096259B2 (en) | 1997-08-04 | 1997-08-04 | Toothpaste |
| JP209010/1997 | 1997-08-04 | ||
| JP00933098A JP3354095B2 (en) | 1997-08-04 | 1998-01-21 | Oral composition |
| JP009330/98 | 1998-01-21 | ||
| JP009330/1998 | 1998-01-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1208604A true CN1208604A (en) | 1999-02-24 |
| CN1151772C CN1151772C (en) | 2004-06-02 |
Family
ID=27278437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB981168612A Expired - Fee Related CN1151772C (en) | 1997-08-04 | 1998-08-03 | Composition for use in oral cavity |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN1151772C (en) |
| HK (1) | HK1017610A1 (en) |
| TW (1) | TW528602B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005319647B2 (en) * | 2004-12-21 | 2011-07-14 | Colgate-Palmolive Company | Anti-caries oral care composition with xylitol |
| CN108904325A (en) * | 2013-06-18 | 2018-11-30 | 株式会社Lg生活健康 | Push type tooth paste product |
-
1998
- 1998-07-17 TW TW87111638A patent/TW528602B/en not_active IP Right Cessation
- 1998-08-03 CN CNB981168612A patent/CN1151772C/en not_active Expired - Fee Related
-
1999
- 1999-06-30 HK HK99102768A patent/HK1017610A1/en not_active IP Right Cessation
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005319647B2 (en) * | 2004-12-21 | 2011-07-14 | Colgate-Palmolive Company | Anti-caries oral care composition with xylitol |
| CN101123939B (en) * | 2004-12-21 | 2012-10-31 | 高露洁-棕榄公司 | Anti-caries oral care composition with xylitol |
| US8858920B2 (en) | 2004-12-21 | 2014-10-14 | Colgate-Palmolive Company | Anti-caries oral care composition with xylitol |
| CN108904325A (en) * | 2013-06-18 | 2018-11-30 | 株式会社Lg生活健康 | Push type tooth paste product |
| US10933003B2 (en) | 2013-06-18 | 2021-03-02 | Lg Household & Health Care Ltd. | Oral composition |
| CN108904325B (en) * | 2013-06-18 | 2022-04-12 | 株式会社Lg生活健康 | Push type toothpaste product |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1151772C (en) | 2004-06-02 |
| HK1017610A1 (en) | 1999-11-26 |
| TW528602B (en) | 2003-04-21 |
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