CN1203860C - 钠离子通道阻断剂和阿司匹林在制备用于对哺乳动物进行协同镇痛的药物中的应用 - Google Patents

钠离子通道阻断剂和阿司匹林在制备用于对哺乳动物进行协同镇痛的药物中的应用 Download PDF

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Publication number
CN1203860C
CN1203860C CNB011159901A CN01115990A CN1203860C CN 1203860 C CN1203860 C CN 1203860C CN B011159901 A CNB011159901 A CN B011159901A CN 01115990 A CN01115990 A CN 01115990A CN 1203860 C CN1203860 C CN 1203860C
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CN
China
Prior art keywords
ion channel
sodium ion
channel blocker
formulation
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB011159901A
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English (en)
Chinese (zh)
Other versions
CN1393223A (zh
Inventor
库宝善
沈希光
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wex Medical Ltd
Original Assignee
Wex Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CNB011159901A priority Critical patent/CN1203860C/zh
Application filed by Wex Medical Ltd filed Critical Wex Medical Ltd
Priority to CA002493885A priority patent/CA2493885C/en
Priority to ES02754135T priority patent/ES2296975T3/es
Priority to JP2003506913A priority patent/JP2004534821A/ja
Priority to DE60223681T priority patent/DE60223681T2/de
Priority to US10/480,288 priority patent/US20040192659A1/en
Priority to EP02754135A priority patent/EP1405639B1/en
Priority to PCT/CN2002/000428 priority patent/WO2003000268A1/zh
Publication of CN1393223A publication Critical patent/CN1393223A/zh
Application granted granted Critical
Publication of CN1203860C publication Critical patent/CN1203860C/zh
Priority to US12/249,802 priority patent/US20090105197A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • A61K31/612Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB011159901A 2001-06-22 2001-06-22 钠离子通道阻断剂和阿司匹林在制备用于对哺乳动物进行协同镇痛的药物中的应用 Expired - Fee Related CN1203860C (zh)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CNB011159901A CN1203860C (zh) 2001-06-22 2001-06-22 钠离子通道阻断剂和阿司匹林在制备用于对哺乳动物进行协同镇痛的药物中的应用
ES02754135T ES2296975T3 (es) 2001-06-22 2002-06-18 Uso de compuestos bloqueantes de canales de sodio y aspirina en la produccion de farmacos para producir efectos analgesicos sinergisticos en mamiferos.
JP2003506913A JP2004534821A (ja) 2001-06-22 2002-06-18 哺乳動物に相乗的鎮痛効果をもたらすための薬剤製造におけるナトリウムチャンネル遮断化合物とアスピリンの使用
DE60223681T DE60223681T2 (de) 2001-06-22 2002-06-18 Verwendung von natriumkanalblockern und aspirin zur herstellung von medikamenten zum erzeugen eines synergistischen analgetischen effekts in säugetieren
CA002493885A CA2493885C (en) 2001-06-22 2002-06-18 Use of sodium channel blocking compounds and aspirin in manufacturing drugs for producing synergistically analgesic effect in mammals
US10/480,288 US20040192659A1 (en) 2001-06-22 2002-06-18 Use of na+ channel blockers and aspirin in manufacturing drugs for producing analgesia synergistically in mammals
EP02754135A EP1405639B1 (en) 2001-06-22 2002-06-18 Use of sodium channel blocking compounds and aspirin in manufacturing drugs for producing synergistic analgesic effect in mammals
PCT/CN2002/000428 WO2003000268A1 (en) 2001-06-22 2002-06-18 Use of na+ channel blockers and aspirin in manufacturing drugs for producing analgesia synergistically in mammals
US12/249,802 US20090105197A1 (en) 2001-06-22 2008-10-10 Use of Sodium Channel Blocking Compounds and Aspirin in Manufacturing Drugs for Producing Analgesia Synergistically in Mammals

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB011159901A CN1203860C (zh) 2001-06-22 2001-06-22 钠离子通道阻断剂和阿司匹林在制备用于对哺乳动物进行协同镇痛的药物中的应用

Publications (2)

Publication Number Publication Date
CN1393223A CN1393223A (zh) 2003-01-29
CN1203860C true CN1203860C (zh) 2005-06-01

Family

ID=4662323

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB011159901A Expired - Fee Related CN1203860C (zh) 2001-06-22 2001-06-22 钠离子通道阻断剂和阿司匹林在制备用于对哺乳动物进行协同镇痛的药物中的应用

Country Status (8)

Country Link
US (2) US20040192659A1 (https=)
EP (1) EP1405639B1 (https=)
JP (1) JP2004534821A (https=)
CN (1) CN1203860C (https=)
CA (1) CA2493885C (https=)
DE (1) DE60223681T2 (https=)
ES (1) ES2296975T3 (https=)
WO (1) WO2003000268A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1568999A (zh) * 2003-07-14 2005-01-26 南宁枫叶药业有限公司 稳定的医药用河豚毒素冷冻干燥制剂
CA2581083A1 (en) * 2004-09-22 2006-03-30 Helmut Henrich Buschmann Tetrodotoxin and its derivatives for the treatment of peripheral-nervously derived neuropathic pain
WO2007025212A2 (en) * 2005-08-25 2007-03-01 Wex Pharmaceuticals, Inc. Use of sodium channel blockers for the treatment of visceral pain or pain caused by cancer treatment
WO2007025213A2 (en) * 2005-08-25 2007-03-01 Wex Pharmaceuticals, Inc. Use of sodium channel blockers for the management of musculoskeletal pain
GB0603008D0 (en) * 2006-02-14 2006-03-29 Portela & Ca Sa Method
EP2012774A1 (en) * 2006-03-27 2009-01-14 Wex Pharmaceuticals, Inc Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy
CN100438873C (zh) * 2006-06-26 2008-12-03 黄致强 将河鲀毒素作为镇痛药的耐受抑制剂在制备复方镇痛制剂中的应用
CN104118237A (zh) * 2013-04-27 2014-10-29 王静娴 编号文件夹

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966934A (en) * 1971-12-08 1976-06-29 Astra Pharmaceutical Products, Inc. Synergistic local anesthetic compositions
US4022899A (en) * 1973-06-12 1977-05-10 Astra Pharmaceutical Products, Inc. Synergistic local anesthetic compositions
US3892847A (en) * 1973-08-14 1975-07-01 Astra Pharma Prod Spinal anesthesia using small amount of saxitoxin
JPS5594319A (en) * 1979-01-09 1980-07-17 Yoshio Otaka Drug for external use consisting of liver oil of swellfish
US6759057B1 (en) * 1986-06-12 2004-07-06 The Liposome Company, Inc. Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs
US5814655A (en) * 1996-11-14 1998-09-29 Insite Vision Incorporated Non-steroidal ophthalmic mixtures
US6030974A (en) * 1997-04-02 2000-02-29 The Regents Of The University Of California Method of anesthesia
GB2339534A (en) * 1998-07-16 2000-02-02 Edko Trading Representation Epidural or intrathecal administration of NSAID's
CN1284536C (zh) * 2000-09-18 2006-11-15 威克斯医药有限公司 河豚毒素或蛤蚌毒素及其类似物在制备用于全身镇痛的镇痛药中的应用

Also Published As

Publication number Publication date
ES2296975T3 (es) 2008-05-01
EP1405639A4 (en) 2004-08-04
US20040192659A1 (en) 2004-09-30
EP1405639B1 (en) 2007-11-21
CN1393223A (zh) 2003-01-29
CA2493885A1 (en) 2003-01-03
DE60223681T2 (de) 2008-10-30
US20090105197A1 (en) 2009-04-23
WO2003000268A8 (en) 2004-03-04
CA2493885C (en) 2007-08-21
JP2004534821A (ja) 2004-11-18
WO2003000268A1 (en) 2003-01-03
EP1405639A1 (en) 2004-04-07
DE60223681D1 (de) 2008-01-03

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Granted publication date: 20050601

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