CN1203792A - Compound pividone iodine sucking tablet - Google Patents
Compound pividone iodine sucking tablet Download PDFInfo
- Publication number
- CN1203792A CN1203792A CN 97105875 CN97105875A CN1203792A CN 1203792 A CN1203792 A CN 1203792A CN 97105875 CN97105875 CN 97105875 CN 97105875 A CN97105875 A CN 97105875A CN 1203792 A CN1203792 A CN 1203792A
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- CN
- China
- Prior art keywords
- iodine
- compound
- tablet
- pividone
- sucking
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a compound povidone-iodine sucking tablet for curing stomatopathy and pharyngolaryngeal diseases and its preparation method. Said invention is technically characterized by that using pivodone-iodine and auxiliary materials of citric acid, etc. and making them into tablet core by means of tablet press, then dissolving dichlofenac sodium in hydroxypropyl methyl cellulose solution to obtain coating solution, then adopting conventional thin-film coating process to coat the external layer of tablet core to form the invented coated compound sucking tablet. Its preparation process is simple, product quality is stable and its clinical therapeutic effect is good.
Description
The present invention relates to a kind of compound pividone iodine sucking tablet, belong to the Western medicine preparation field.
Oral disease (oral ulcer, pharyngitis, gingivitis) is a common clinical, frequently-occurring disease.Many also have because of smoking owing to streptococcus, viral infection cause, and outside stimulus etc. cause.Admittedly be divided into infectious and non-infectious two kinds.The medicine of this disease of treatment has domiphen bromide, cydiodine, Herba Pileae Scriptae etc. at present, in the middle of this class medicine, how with sterilization, anti-inflammation drugs is main, curative effect is more definite, but the pain that can not eliminate a disease and bring to the patient makes the patient very painful in the quite long course of disease.
Purpose of the present invention is at infectious and non-infectious oral cavity, the characteristics that laryngopharyngeal diseases is dissimilar, provide a kind of can sterilize also can anti-inflammatory analgetic compound pividone iodine sucking tablet, to satisfy clinical needs.
Technical characterstic of the present invention is that to select povidone iodine for use be antibacterial, and diclofenac sodium is an anti-inflammation analgesic.Wherein povidone iodine is the potent antibacterial of generally acknowledging in the world, and the polyvidone pair cell has strong affinity, can strengthen the sterilizing power of iodine with on the iodine transporte to cells film.The anti-inflammatory analgesic action that the diclofenac sodium tool is stronger, local application, curative effect height, onset are rapid.After taking medicine.Place the diclofenac sodium of outer coating membrane at first to dissolve, discharge, absorb, make illness place anti-inflammatory analgetic.Subsequently, the povidone iodine of inner core discharges, and plays bactericidal action.
The present invention is achieved in that compound pividone iodine sucking tablet, comprises two kinds of compositions of povidone iodine and diclofenac sodium.The content of two kinds of compositions is respectively povidone iodine 15mg, diclofenac sodium 2mg.Its preparation method is: 1. povidone iodine and Icing Sugar, citric acid, arabic gum, Mentholum are made conventional tablet; 2. diclofenac sodium is dissolved in the Gonak that contains ethanol 70%, makes coating solution; The coating solution that 3. will contain diclofenac sodium is sprayed on the povidone iodine label, makes the polyvidone iodine tablet of compound recipe.Compound pividone iodine sucking tablet clinical application of the present invention is the inflammation pain that buccal treatment pharyngitis, oral ulcer, tonsillitis, gingivitis cause.
Conventional equipment is used in compound povidone iodine sheet preparation of the present invention, and supplementary material is easy to get, and technology is easy, steady quality, and under 40 ℃ of relative humidity 75% conditions, packaging and storing is more than six months, and quality does not have significant change.
The embodiment of the invention
1, the label prescription is 1000
Povidone iodine 15g
Icing Sugar 350g
Citric acid 2.6g
Arabic gum 60g
Mentholum 0.4g
70% ethanol water 60ml
Magnesium stearate 1 ‰
2, preparation method: povidone iodine 15g is crossed 80 mesh sieves,, add 70% ethanol water 60ml, stir the system soft material, granulate with 16 mesh sieves with other composition mixings of prescription, 40 ℃ of oven dry, dried granule adds magnesium stearate Mentholum fine powder, behind the mixing, 16 mesh sieve granulate.Tabletting, every contain povidone iodine 15mg (containing active iodine 1.5mg)
3, diclofenac sodium coatings
(1) diclofenac sodium coating solution prescription.
Diclofenac sodium 12.6g
Hydroxypropyl emthylcellulose 50g
95% ethanol 700g
Saccharin sodium 4g
Mentholum 2g
Water adds to 1000ml
(2) preparation method, hydroxypropyl emthylcellulose 50g is added in the 1000ml ethanol water, and the adding saccharin sodium, Mentholum, stir, to dissolving fully, with povidone iodine agreement that contracts a film or TV play to an actor or actress 2kg, put in the coating pan and heat 37 ℃-40 ℃, rotating speed is 10rpm, and air compressor pressure is 4 atmospheric pressure, with PQ-2 type spray gun, the coating solution 1200ml for preparing is sprayed on the polyvidone iodine tablet continuously.40 ℃ of hot air dryings took out after 30 minutes, drying below 40 ℃ 5 hours.Every contains povidone iodine 15mg, (iodine 1.5mg), diclofenac sodium 2mg.
The present invention has adopted PVP-I and the diseases such as C14H10Cl2NNaO2 compound treatment canker sore and pharyngitis, Have that side effect is little, drug effect is rapid, obviously improve the characteristics such as patient's misery, confirm through animal pharmacological experiment Tablet of the present invention is for staphylococcus aureus, beta hemolytic streptococcus, Escherichia coli and Pseudomonas aeruginosa Killing effect remarkable, remarkable to the antiinflammatory action of rabbit vocal cords inflammatory model, analgesic activity is better than anti-inflammatory Bitterly (1-3 sees attached list).
Minimal inhibitory concentration and the sterilizing time of subordinate list 1 compound povidone iodine sheet
Bacterium minimal inhibitory concentration (ug/ml) sterilizing time (minute)
Staphylococcus aureus 160 2
Beta hemolytic streptococcus 160 2
Escherichia coli 80 2
Bacillus pyocyaneus 320 4
Subordinate list 2 compound povidone iodine sheets are to the inhibitory action of rabbit vocal cords inflammation
Medicine inhibitory rate of intumesce (%) oozes out suppression ratio (%)
Normal saline--
0.025% topsyne 39.37 63.22
0.75% compound recipe sheet 27.6 39.08
1.5% compound recipe sheet 40.27 51.72
Subordinate list 3 compound povidone iodine sheets are to the analgesic activity of mice acetic acid twisting reaction
Medicine analgesia rate (%) writhing response rate (%) turn round the body number of times (inferior/30min)
Normal saline-85 23.65 ± 13.48
0.5% indometacin 64.7 30 19.83 ± 16.73
0.375% compound recipe sheet 64.7 30 10.33 ± 9.48
0.75% compound recipe sheet 82.35 15 4.33 ± 1.53
Claims (2)
1, a kind of compound pividone iodine sucking tablet comprises two kinds of compositions of povidone iodine and diclofenac sodium, it is characterized in that povidone iodine is 15mg, and diclofenac sodium is 2mg.
2, compound pividone iodine sucking tablet according to claim 1 is characterized in that clinical application is buccal treatment pharyngitis, oral ulcer, tonsillitis, the inflammation pain that gingivitis causes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97105875 CN1203792A (en) | 1997-06-02 | 1997-06-02 | Compound pividone iodine sucking tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97105875 CN1203792A (en) | 1997-06-02 | 1997-06-02 | Compound pividone iodine sucking tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1203792A true CN1203792A (en) | 1999-01-06 |
Family
ID=5168169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 97105875 Pending CN1203792A (en) | 1997-06-02 | 1997-06-02 | Compound pividone iodine sucking tablet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1203792A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002102356A3 (en) * | 2001-06-16 | 2003-03-06 | Boots Co Plc | Medicinal compositions comprising a melting core encapsulated in a hydroxypropylmethylcellulose film |
| CN1330314C (en) * | 2004-01-13 | 2007-08-08 | 浙江众益药业有限公司 | Cydiodine buccal tablet |
| FR3122086A1 (en) * | 2021-04-22 | 2022-10-28 | Nadine GRISLAIN | Suction tablet based on PVPI without cellulosic excipients. |
-
1997
- 1997-06-02 CN CN 97105875 patent/CN1203792A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002102356A3 (en) * | 2001-06-16 | 2003-03-06 | Boots Co Plc | Medicinal compositions comprising a melting core encapsulated in a hydroxypropylmethylcellulose film |
| US7780977B2 (en) | 2001-06-16 | 2010-08-24 | Bioprogress Technology Limited | Medication compositions |
| CN1330314C (en) * | 2004-01-13 | 2007-08-08 | 浙江众益药业有限公司 | Cydiodine buccal tablet |
| FR3122086A1 (en) * | 2021-04-22 | 2022-10-28 | Nadine GRISLAIN | Suction tablet based on PVPI without cellulosic excipients. |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |