CN1203189A - Improved preparing process for changing coral into hydroxy-apatite 'artificial bone' - Google Patents
Improved preparing process for changing coral into hydroxy-apatite 'artificial bone' Download PDFInfo
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- CN1203189A CN1203189A CN 98113252 CN98113252A CN1203189A CN 1203189 A CN1203189 A CN 1203189A CN 98113252 CN98113252 CN 98113252 CN 98113252 A CN98113252 A CN 98113252A CN 1203189 A CN1203189 A CN 1203189A
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- coral
- artificial bone
- apatite
- hydroxy
- pressure
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Abstract
An improved process for transforming coral into "artificial bone" of hydroxyphosphorite includes immersing coral in high-concentration phosphorate solution under 1 kg/sq.cm-300 kg/sq.cm pressure and at 190-200 deg.C reacting for 7-8 hr, washing with distilled water at 100 deg.C until there is no organic salt component, dewatering, drying at 100 deg.C, and high-temp. and gas sterilization, and features the reaction under low-or medium-pressure, shorter reaction time, slow dissolving of product in acidic medium, and high quality and low cost of product.
Description
The present invention relates to a kind of improved preparation technology who coral is changed into hydroxy-apatite ' artificial bone '.
" artificial bone " that hydroxyapatite is made has excellent biological compatibility and bone affinity.With reagent hydroxyapatite hydrostatic profile, " artificial bone " that high temperature sintering is made do not used in some do not bear the damaged operation of bone of big pressure.But the material of this type is subjected to certain limitation in the foaming sintering process, and artificial bone requires have one to fix on sedimentation, and in order to the growth of blood vessel and tissue, but intensity then is subjected to certain restriction, moreover their reticulated structure does not interconnect.The characteristics that the foreign scholar utilizes coral to have special vesicular structure and hole evenly to communicate through the processing of certain program, are made artificial bone and are used.But the composition of coral is CaCO
3, meet acidic medium and decompose easily, so when implanting in the animal body, very fast degraded is not exclusively repaired defective region.They further carry out chemical treatment with coral, with CaCO
3Composition becomes hydroxyapatite, makes it have porousness concurrently and is easy to physiologically acceptable, the advantage that biodegradation rate is slow.Be made into " artificial bone " material, obviously be better than " artificial bone " made with the reagent hydroxyapatite.But CaCO with coral
3Composition changes the composition of hydroxyapatite into, and their vesicular structure keeps again, and is then very complicated aspect processing condition.
The object of the present invention is to provide the improved preparation technology who coral is changed into hydroxy-apatite ' artificial bone ' that a kind of reaction times is shorter, cost is low.
The present invention is achieved in that and is made into 50% solution soaking coral with phosphoric acid salt (as Secondary ammonium phosphate, Sodium phosphate dibasic etc.), at 1kg/cm
2～300kg/cm
2Following 190 ℃～200 ℃ of pressure reacted 7～8 hours, with distilled water 100 ℃ of following washings to there not being the organic salt composition, dehydration, 100 ℃ of dryings, high temperature and gas depoisonings.
Below in conjunction with embodiment the present invention is described in detail.
Embodiment one: get 50% Secondary ammonium phosphate, disodium phosphate soln 50ml and 20 gram corals mix, normal pressure or with nitrogen pressure to 100kg/cm
2, being heated to 190 ℃, constant temperature 8 hours takes out, and washs 10 times each water 100ml for 100 ℃ down with distilled water.Dehydration, drying, high temperature (120 ℃) and gas depoisoning.
Embodiment two: get 50% Secondary ammonium phosphate, solution of ammonium hydroxide 50ml and 20 gram corals mix 1kg/cm
2Pressure heats 190 ℃ down, and constant temperature cooled off, takes out after 3 hour, and the liquid of falling the dereaction adds 50% above-mentioned solution 50ml more again at 1kg/cm
2Be heated to 190 ℃ under the pressure, constant temperature 4 hours, washing, drying, all the other are with embodiment one.
The product that makes with this technology can be made " ocular prosthesis seat " and the sheet material of all kinds of " artificial bones " of all size.
Technology of the present invention has following advantage:
1. this technology can be carried out under the press strip spare in low, react the needed time more to shorten, And the end product quality that makes is higher, and price is low.
2. with this technology CO
2- 3Substitution rate is more complete, and products obtained therefrom dissolves in acidic medium slowly, and the hydroxyl characteristic peak is obvious, the results of elemental analyses indifference.
Claims (1)
1. one kind improvedly changes coral the preparation technology of hydroxy-apatite ' artificial bone ' into, it is characterized in that: be made into 50% solution soaking coral with phosphoric acid salt (as Secondary ammonium phosphate, Sodium phosphate dibasic etc.), at 1kg/cm
2～300kg/cm
2Following 190 ℃～200 ℃ reactions of pressure 7～8 hours, with distilled water 100 ℃ of following washings to there not being the organic salt composition, dewater 100 ℃ of dryings, high temperature and gas depoisonings.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98113252 CN1128097C (en) | 1998-06-19 | 1998-06-19 | Improved preparing process for changing coral into hydroxy-apatite 'artificial bone' |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98113252 CN1128097C (en) | 1998-06-19 | 1998-06-19 | Improved preparing process for changing coral into hydroxy-apatite 'artificial bone' |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1203189A true CN1203189A (en) | 1998-12-30 |
| CN1128097C CN1128097C (en) | 2003-11-19 |
Family
ID=5223006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 98113252 Expired - Fee Related CN1128097C (en) | 1998-06-19 | 1998-06-19 | Improved preparing process for changing coral into hydroxy-apatite 'artificial bone' |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1128097C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2863172A1 (en) * | 2003-12-05 | 2005-06-10 | Biocoral Inc | Extracting organic substances from coral for making bone substitutes comprises treating the coral with a fluid at a defined temperature |
| CN101843919A (en) * | 2010-05-31 | 2010-09-29 | 哈尔滨师范大学 | Method for preparing hydroxyapatite/composite hole bioactive glass |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100384488C (en) * | 2004-05-28 | 2008-04-30 | 梁辉 | Preparation technique of absorbent hydroxyapatite artificial bone |
| JP5911809B2 (en) | 2010-01-22 | 2016-04-27 | トムソン ライセンシングＴｈｏｍｓｏｎ Ｌｉｃｅｎｓｉｎｇ | Sampling-based super-resolution video encoding and decoding method and apparatus |
-
1998
- 1998-06-19 CN CN 98113252 patent/CN1128097C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2863172A1 (en) * | 2003-12-05 | 2005-06-10 | Biocoral Inc | Extracting organic substances from coral for making bone substitutes comprises treating the coral with a fluid at a defined temperature |
| WO2005055885A1 (en) * | 2003-12-05 | 2005-06-23 | Bio Holdings International Limited | Coral purification method and coral thus obtained |
| US7608283B2 (en) | 2003-12-05 | 2009-10-27 | Biocoral Inc. | Coral purification method and coral thus obtained |
| CN101843919A (en) * | 2010-05-31 | 2010-09-29 | 哈尔滨师范大学 | Method for preparing hydroxyapatite/composite hole bioactive glass |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1128097C (en) | 2003-11-19 |
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| C14 | Grant of patent or utility model | ||
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| CF01 | Termination of patent right due to non-payment of annual fee |