CN1197974C - Digestive system tumor diagnosis kit - Google Patents
Digestive system tumor diagnosis kit Download PDFInfo
- Publication number
- CN1197974C CN1197974C CN 01139260 CN01139260A CN1197974C CN 1197974 C CN1197974 C CN 1197974C CN 01139260 CN01139260 CN 01139260 CN 01139260 A CN01139260 A CN 01139260A CN 1197974 C CN1197974 C CN 1197974C
- Authority
- CN
- China
- Prior art keywords
- gpda
- serum
- reagent
- cancer
- reagent kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000002699 Digestive System Neoplasms Diseases 0.000 title claims abstract description 5
- 238000003745 diagnosis Methods 0.000 title claims description 6
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 21
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 12
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 238000012360 testing method Methods 0.000 claims description 6
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 6
- 108010008488 Glycylglycine Proteins 0.000 claims description 4
- 239000007983 Tris buffer Substances 0.000 claims description 4
- 229940043257 glycylglycine Drugs 0.000 claims description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 3
- INEWUCPYEUEQTN-UHFFFAOYSA-N 3-(cyclohexylamino)-2-hydroxy-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(O)CNC1CCCCC1 INEWUCPYEUEQTN-UHFFFAOYSA-N 0.000 claims description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 3
- 229940098773 bovine serum albumin Drugs 0.000 claims description 3
- 108010010043 glycylproline dipeptidyl aminopeptidase Proteins 0.000 abstract description 50
- 210000002966 serum Anatomy 0.000 abstract description 36
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 13
- 201000007270 liver cancer Diseases 0.000 abstract description 9
- 208000014018 liver neoplasm Diseases 0.000 abstract description 9
- 206010017758 gastric cancer Diseases 0.000 abstract description 7
- 201000011549 stomach cancer Diseases 0.000 abstract description 7
- 239000000758 substrate Substances 0.000 abstract description 6
- 239000007788 liquid Substances 0.000 abstract description 4
- 238000012544 monitoring process Methods 0.000 abstract description 4
- XHLUWCXVWCBOPP-MERQFXBCSA-N (2s)-1-(2-aminoacetyl)-n-(4-nitrophenyl)pyrrolidine-2-carboxamide;4-methylbenzenesulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1.NCC(=O)N1CCC[C@H]1C(=O)NC1=CC=C([N+]([O-])=O)C=C1 XHLUWCXVWCBOPP-MERQFXBCSA-N 0.000 abstract 1
- 230000000630 rising effect Effects 0.000 description 7
- 201000000498 stomach carcinoma Diseases 0.000 description 7
- 208000025865 Ulcer Diseases 0.000 description 6
- 231100000397 ulcer Toxicity 0.000 description 6
- 230000007423 decrease Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 102100023635 Alpha-fetoprotein Human genes 0.000 description 3
- 208000007882 Gastritis Diseases 0.000 description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 3
- 108010026331 alpha-Fetoproteins Proteins 0.000 description 3
- 208000023652 chronic gastritis Diseases 0.000 description 3
- 201000005202 lung cancer Diseases 0.000 description 3
- 208000020816 lung neoplasm Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
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- 206010027457 Metastases to liver Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 201000004637 gastric cardia carcinoma Diseases 0.000 description 2
- 201000011066 hemangioma Diseases 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
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- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 208000017897 Carcinoma of esophagus Diseases 0.000 description 1
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 101710173228 Glutathione hydrolase proenzyme Proteins 0.000 description 1
- 206010019728 Hepatitis alcoholic Diseases 0.000 description 1
- 206010019755 Hepatitis chronic active Diseases 0.000 description 1
- 206010023129 Jaundice cholestatic Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
- 201000005267 Obstructive Jaundice Diseases 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
- 108010077465 Tropocollagen Proteins 0.000 description 1
- 231100000354 acute hepatitis Toxicity 0.000 description 1
- 208000002353 alcoholic hepatitis Diseases 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 201000005619 esophageal carcinoma Diseases 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- WGXUDTHMEITUBO-YFKPBYRVSA-N glutaurine Chemical compound OC(=O)[C@@H](N)CCC(=O)NCCS(O)(=O)=O WGXUDTHMEITUBO-YFKPBYRVSA-N 0.000 description 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000024557 hepatobiliary disease Diseases 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000005228 liver tissue Anatomy 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 208000025036 lymphosarcoma Diseases 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- ZRHANBBTXQZFSP-UHFFFAOYSA-M potassium;4-amino-3,5,6-trichloropyridine-2-carboxylate Chemical compound [K+].NC1=C(Cl)C(Cl)=NC(C([O-])=O)=C1Cl ZRHANBBTXQZFSP-UHFFFAOYSA-M 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 01139260 CN1197974C (en) | 2001-12-27 | 2001-12-27 | Digestive system tumor diagnosis kit |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 01139260 CN1197974C (en) | 2001-12-27 | 2001-12-27 | Digestive system tumor diagnosis kit |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1428436A CN1428436A (en) | 2003-07-09 |
CN1197974C true CN1197974C (en) | 2005-04-20 |
Family
ID=4675182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 01139260 Expired - Lifetime CN1197974C (en) | 2001-12-27 | 2001-12-27 | Digestive system tumor diagnosis kit |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1197974C (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100353166C (en) * | 2004-08-30 | 2007-12-05 | 北京源德生物医学工程有限公司 | Enzyme tag stabilizing agent |
CN104880423A (en) * | 2015-05-08 | 2015-09-02 | 浙江蓝森生物科技有限公司 | Method, reagent and kit for quantitatively determining activity of glycylproline dipeptidyl aminopeptidase in human serum |
CN105510572A (en) * | 2015-12-22 | 2016-04-20 | 山东博科生物产业有限公司 | Detection kit for glycylproline dipeptidyl aminopeptidase |
CN105861632A (en) * | 2016-04-28 | 2016-08-17 | 安徽伊普诺康生物技术股份有限公司 | Kit for determining glycylproline dipeptide aminopeptidase |
-
2001
- 2001-12-27 CN CN 01139260 patent/CN1197974C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1428436A (en) | 2003-07-09 |
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Legal Events
Date | Code | Title | Description |
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C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Zhejiang Kuake Biotechnology Co.,Ltd. Assignor: Zhang Kang Contract fulfillment period: 2009.10.30 to 2014.12.31 Contract record no.: 2009330002876 Denomination of invention: Digestive system tumor diagnosis kit Granted publication date: 20050420 License type: Exclusive license Record date: 20091204 |
|
LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.10.30 TO 2014.12.31; CHANGE OF CONTRACT Name of requester: ZHEJIANG KUAKE BIOSCIENCE TECHNOLOGY CO., LTD. Effective date: 20091204 |
|
EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Zhejiang Kuake Biotechnology Co.,Ltd. Assignor: Zhang Kang Contract record no.: 2009330002876 Date of cancellation: 20130521 |
|
LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20030709 Assignee: Zhejiang Kuake Biotechnology Co.,Ltd. Assignor: Zhang Kang Contract record no.: 2013990000306 Denomination of invention: Digestive system tumor diagnosis kit Granted publication date: 20050420 License type: Exclusive License Record date: 20130607 |
|
LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170606 Address after: 312500 Xinchang provincial hi tech Industrial Park, Zhejiang, Shaoxing province (1 Jiangdong Road) Patentee after: Zhejiang Kuake Biotechnology Co.,Ltd. Address before: 200083 room 26, room 818, Lane 603, water circuit, Shanghai Patentee before: Zhang Kang |
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TR01 | Transfer of patent right | ||
CX01 | Expiry of patent term |
Granted publication date: 20050420 |
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CX01 | Expiry of patent term |