CN1197590C - Bee product composition for curing diabetes and its preparation method - Google Patents
Bee product composition for curing diabetes and its preparation method Download PDFInfo
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- CN1197590C CN1197590C CNB021099308A CN02109930A CN1197590C CN 1197590 C CN1197590 C CN 1197590C CN B021099308 A CNB021099308 A CN B021099308A CN 02109930 A CN02109930 A CN 02109930A CN 1197590 C CN1197590 C CN 1197590C
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- propolis
- product composition
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- royal jelly
- diabetes
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Abstract
The present invention relates to a bee product composition for treating diabetes and a preparation method thereof. The bee product composition is prepared from the following method: a) after impurities are removed, bee pollen is frozen at the temperature of-18 to-20 DEG C for 20 to 24 hours and is hulled on standby; b) edible alcohol is added into propolis, and the content of the alcohol is sufficient for dissolving the propolis; then, the supernatant fluid is taken out and is heated at the temperature of lower than 60 DEG C until the alcohol is volatilized and the propolis is separated out; c) fresh royal jelly or freeze-dried royal jelly powder is taken on standby; d) 7 to 13 of bee pollen processed in a), 1 of propolis obtained in b) and 3 to 7 of fresh royal jelly or freeze-dried royal jelly powder of c) are mixed according to weight ratio to obtain the required product. The bee product composition has the advantages of no stimulation, no toxic or side effect and low treatment cost, and the cost is only about one third of that of the existing chemicals for treating diabetes. The bee product composition has a very obvious therapeutic effect on treating diabetes (particularly diabetes of type II).
Description
Technical field
The present invention relates to be used for the treatment of the bee product composition of diabetes.
Background technology
The mode for the treatment of diabetes at present clinically has three kinds, is respectively: 1, adopt chemicalses such as sulphanylureas, biguanides; 2, adopt single bee product, as: any one in bee pollen or its goods (such as pollen oral solution), propolis, fresh royal jelly or Lac regis apis lyophilized powder, honeybee pin or its goods (such as honeybee pin liquid); 3, adopt chemicals to combine, but the curative effect of these three kinds of therapeutic modalities is all not good, and chemicals also have the effect of paying to human body with single bee product.
Summary of the invention
The object of the present invention is to provide a kind of bee product composition that is used for the treatment of diabetes, have bee pollen, propolis, fresh royal jelly or Lac regis apis lyophilized powder in the said composition, make the therapeutic equivalence of its treatment diabetes remarkable.
The invention provides a kind of bee product composition that is used for the treatment of diabetes, it presses (7～13) by bee pollen, propolis, fresh royal jelly or Lac regis apis lyophilized powder: 1: the weight ratio of (3～7) is mixed and is formed.
The preparation method of described bee product composition may further comprise the steps: a) with the bee pollen after the remove impurity under-18～-20 ℃ temperature freezing 20～24 hours, broken shell was standby; B) add edible ethanol in propolis, alcohol content is for being enough to make the propolis dissolving, gets the supernatant then and heats being lower than under 60 ℃ the temperature, till the ethanol volatilization, separating out propolis; C) get fresh royal jelly or Lac regis apis lyophilized powder is standby; D) with bee pollen, b in a)) in propolis, c) in fresh royal jelly or Lac regis apis lyophilized powder by (7～13): 1: the weight ratio of (3～7) is mixed, and obtains required product.
The mechanism of action of bee pollen, propolis, fresh royal jelly or Lac regis apis lyophilized powder treatment diabetes is respectively:
Bee pollen can promote the growth of islets of langerhans body of gland, strengthens the ability of islet secretion, and serum triglycerides, serum total cholesterol content are reduced, and serum low-density LP content raises, and to preventing and treating diabetes certain positive role is arranged; Propolis has stronger antiinflammatory, sterilization, antivirus action, in 39 kinds of antibacterials, propolis has very strong killing action to 25 kinds of antibacterials, particularly responsive especially to gram-positive bacterium, acid bacteria and staphylococcus aureus, islet cells is subjected to the source of disease infected by microbes to obtain prevention, can effectively reduce islet cells and cause the probability of pathological changes because of being subjected to the source of disease infected by microbes; The basis of fresh royal jelly or Lac regis apis lyophilized powder is protein, protein active ingredients can be divided into three major types: (1) para-insulin (2) active polypeptide (3) globulin, the para-insulin molecular weight is identical with the bovine insulin molecular weight, oral fresh royal jelly or Lac regis apis lyophilized powder just equal direct supplementation with insulin, thereby diabetics is had the positive therapeutic effect;
In addition, the abundant vitamin of content is arranged in bee pollen, propolis, fresh royal jelly or the Lac regis apis lyophilized powder, can prevent that tryptophan transfer from turning to yellow propylhomoserin, avoid yellow propylhomoserin that the islets of langerhans inner cell is produced destruction, make islets of langerhans can not lose the function of excreting insulin, reduce the morbidity risk rate of diabetes or alleviate its symptom; Bee pollen; propolis; content abundant macroelement and chromium are arranged in fresh royal jelly or the Lac regis apis lyophilized powder; calcium; magnesium; 27 kinds of trace element such as zinc (and human body only needs 15 kinds of trace element); these elements play positive role to the biosynthesis and the energy i (in vivo) metabolism of insulin; as: chromium can activate insulin; improve carbohydrate tolerance; calcium is to insulin secretion; release has good action; zinc can be protected the 26S Proteasome Structure and Function of insulin; keep proteinic homergy; and sterilization arranged; antiinflammatory; antivirus action; avoiding due to illness, pathogenic microorganism infects the generation of the multiple complications of being brought; magnesium can promote the discharge of cholesterol, reduces the probability (as the damage of eye and heart) that diabetic complication occurs.
Make bee pollen, propolis, after fresh royal jelly or Lac regis apis lyophilized powder are mixed, when prepared bee product composition is treated diabetes, bee pollen, propolis, outside fresh royal jelly or the Lac regis apis lyophilized powder decapacitation performance therapeutical effect separately, also can organicly cooperate between this three, complement one another, the common islet function that promotes improves, amount of insulin secretion is increased, therefore, the curative effect of this bee product composition is quite significant, because the cause of disease of type ii diabetes (non-insulin-depending type) is that insulin lacks relatively, so this bee product composition is particularly remarkable for the therapeutic effect of type ii diabetes.
This bee product composition, non-stimulated and malicious pair of effect, price only are to have about 1/3rd of the chemical drugs price of treatment diabetes now, treat cost and greatly reduce, and can play the effect of " integration of edible and medicinal herbs, cure have both " to diabetics, long better with effect.
In order to understand essence of the present invention better, will further specify the beneficial effect that uses this bee product composition treatment diabetes below by the contrast test of treatment group, matched group:
1 grouping and Therapeutic Method
1.1 grouping: successively the patient is divided into treatment group and matched group at random by consultation time, 54 examples are organized in treatment, matched group 51 examples (standard of the concrete standard reference of diagnosing diabetes WHO in 1997 and ADA is carried out);
1.2 treatment group: use this bee product composition that the patient is carried out treatment of diabetes;
1.3 matched group: use conventional chemical medicine (as diabetes pill, D860, glyburide, diamicron, gliquidone etc.) that the patient is carried out treatment of diabetes;
1.4 the course of treatment: treatment group and matched group were a course of treatment in equal 30 days.
The related data of 2 treatment groups and matched group
2.1 sex distributes, and sees Table one:
Table one
| Group | The example number | The man | The woman |
| The treatment group | 54 | 32 | 22 |
| Matched group | 51 | 3 0 | 21 |
2.2 age distribution sees Table two:
Table two
| Group | The example number | Below 40 years old | 41～60 years old | More than 60 years old |
| The treatment group | 54 | 18 | 34 | 2 |
| Matched group | 51 | 22 | 25 | 4 |
2.3 course of disease situation sees Table three:
Table three
| Group | The example number | Below 2 years | 3～5 years | 6～10 years | 11～15 years |
| The treatment group | 54 | 8 | 33 | 9 | 4 |
| Matched group | 51 | 7 | 31 | 7 | 6 |
2.4 blood sugar content (mM/liter), see Table four:
Table four
| Group | The example number | Blood glucose is 14.0 | Blood glucose is 14～16.0 | Blood glucose is 16.0 |
| The treatment group | 54 | 15 | 26 | 13 |
| Matched group | 51 | 16 | 27 | 8 |
3 efficacy assessment standards
3.1 produce effects: patient's polydipsia, polyuria, polyphagia transference cure, fasting glucose and glucose in urine recover normal, or reduce lift-off value more than 50%;
3.2 take a turn for the better: patient's symptom disappears substantially, the lift-off value of fasting glucose and glucose in urine descends 30%;
3.3 it is invalid: the commentaries on classics of not getting better of patient's symptom, the lift-off value decline less than 20% of fasting glucose and glucose in urine.
4 result of the tests (after two courses of treatment) see Table five:
Table five
| Group | The example number | Produce effects | Take a turn for the better | Invalid | Total effective rate |
| The treatment group | 54 | 38 | 14 | 2 | 96.29％ |
| Matched group | 51 | 14 | 30 | 7 | 86.27％ |
From above contrast test and result, can draw and the invention has the advantages that: the curative effect of this bee product composition treatment diabetes (especially type ii diabetes) is quite significant.
The specific embodiment
The several embodiment of various details, but content of the present invention is not limited to this fully.
Embodiment 1: with the bee pollen after the remove impurity under-18 ℃ temperature freezing 24 hours, broken shell was standby; Add edible ethanol in propolis, alcohol content is for being enough to make the propolis dissolving, gets the supernatant then and heats under 50 ℃ temperature, till the ethanol volatilization, separating out propolis, to remove the impurity in the propolis; It is standby to get fresh royal jelly; Above-mentioned bee pollen, the propolis after the roguing, the fresh royal jelly of handling through broken shell mixed by 7: 1: 3 weight ratio, obtain required bee product composition.
Embodiment 2: with the bee pollen after the remove impurity under-19 ℃ temperature freezing 22 hours, broken shell was standby; Add edible ethanol in propolis, alcohol content is for being enough to make the propolis dissolving, gets the supernatant then and heats under 55 ℃ temperature, till the ethanol volatilization, separating out propolis, to remove the impurity in the propolis; It is standby to get fresh royal jelly; Above-mentioned bee pollen, the propolis after the roguing, the fresh royal jelly of handling through broken shell mixed by 9: 1: 6 weight ratio, obtain required bee product composition.
Embodiment 3: with the bee pollen after the remove impurity under-20 ℃ temperature freezing 20 hours, broken shell was standby; Add edible ethanol in propolis, alcohol content is for being enough to make the propolis dissolving, gets the supernatant then and heats under 59 ℃ temperature, till the ethanol volatilization, separating out propolis, to remove the impurity in the propolis; It is standby to get commercially available Lac regis apis lyophilized powder; Above-mentioned bee pollen, the propolis after the roguing, the Lac regis apis lyophilized powder of handling through broken shell mixed by 13: 1: 7 weight ratio, obtain required bee product composition.
Claims (1)
1, the bee product composition that is used for the treatment of diabetes, it presses (7～13) by bee pollen, propolis, fresh royal jelly or Lac regis apis lyophilized powder: 1: the weight ratio of (3～7) is mixed and is formed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021099308A CN1197590C (en) | 2002-01-20 | 2002-01-20 | Bee product composition for curing diabetes and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021099308A CN1197590C (en) | 2002-01-20 | 2002-01-20 | Bee product composition for curing diabetes and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1366885A CN1366885A (en) | 2002-09-04 |
| CN1197590C true CN1197590C (en) | 2005-04-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB021099308A Expired - Fee Related CN1197590C (en) | 2002-01-20 | 2002-01-20 | Bee product composition for curing diabetes and its preparation method |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5305577B2 (en) * | 2006-10-24 | 2013-10-02 | 株式会社山田養蜂場本社 | Composition for preventing / treating diabetic disease and functional food for preventing / ameliorating diabetic disease |
| CN102934769B (en) * | 2012-11-30 | 2013-12-04 | 扬州大学 | Bee pollen mixture buccal tablet for alleviating hangovers |
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2002
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| CN1366885A (en) | 2002-09-04 |
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