CN1192474A - Prodn. process for extracting sodium citrate from citric acid fermentation liquor - Google Patents
Prodn. process for extracting sodium citrate from citric acid fermentation liquor Download PDFInfo
- Publication number
- CN1192474A CN1192474A CN98101098A CN98101098A CN1192474A CN 1192474 A CN1192474 A CN 1192474A CN 98101098 A CN98101098 A CN 98101098A CN 98101098 A CN98101098 A CN 98101098A CN 1192474 A CN1192474 A CN 1192474A
- Authority
- CN
- China
- Prior art keywords
- citric acid
- trisodium citrate
- acid fermentation
- liquid
- fermentation broth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The prodn. technology of sodium citrate is characterized by that chromatographic separation principle is used to produce and separate sodium citrate directly from the fermentation liquid of citric acid. The process includes filter pressing of the fermentation liquid, decolourizing, demineraizing, chromatographic separation of sodium citrate, concentration of the separated liquid, crystallization and drying. The invented technology possesses the advantages of short process flow, low prodn. cost, complete pipelined operation and no environmental pollution.
Description
The present invention relates to a kind of production technique of from citric acid fermentation broth, extracting Trisodium Citrate, more particularly relate to a kind of chromatographic separation principle of utilizing and from the citric acid fermentation broth of different fermenting raw materials, directly generate the also production technique of separation of citric acid sodium.
Trisodium Citrate is a kind of important organic acid salt product that is widely used in industries such as medicine, food, photograph, plating and washing.
The Trisodium Citrate production method of using mainly contains following two kinds at present:
1. use product citric acid and sodium hydroxide or yellow soda ash to carry out neutralization reaction in the aqueous solution and generate Trisodium Citrate, sodium citrate solution condensing crystal after decolouring obtains product.
2. use replacement(metathesis)reaction to produce Trisodium Citrate from citric acid fermentation broth.In this technology, citric acid fermentation broth through lime carbonate neutralization, calcium citrate salts washing, calcium citrate salts and sodium carbonate solution carry out replacement(metathesis)reaction, filter lime carbonate, operation compositions such as sodium citrate solution decolouring back concentrates, crystallization and product drying.
All there is weak point in the production method of above-mentioned two kinds of Trisodium Citrates, and first method adopts finished lemon acid to produce Trisodium Citrate, the production cost height, and economic benefit is low.Though second kind of technology adopts citric acid fermentation broth to produce Trisodium Citrate, the replacement(metathesis)reaction time is long, and operational condition is poor, and the product economy benefit is not too obvious.
In addition, people wish to adopt ion exchange method direct production Trisodium Citrate from citric acid fermentation broth.In the method, citric acid fermentation broth is through ion exchange column absorption, obtain sodium citrate solution with the sodium hydroxide desorb, and this solution goes to carry out behind the readily carbonizable substance that product is concentrated, crystallizing and drying again.Though this method principle is easier than above-mentioned two kinds of methods, weak point is the sodium citrate solution that sodium citrate solution still need go the readily carbonizable substance operation just can obtain purifying.
The objective of the invention is to overcome the existing deficiency of above-mentioned several production technology of sodium citrate, a kind of technical process is simple, yield is high, cost is low, the operation canalization and provide, the direct also production technique of being convenient to manage of separation of citric acid sodium that generates from the citric acid fermentation broth of different fermenting raw materials.
The objective of the invention is that following technical proposals realizes by using: 1. be that the fermented liquid of 1%-20% (weight) carries out filter press or centrifugation to remove solid impurity such as mycelium with citric acid content, obtain the citric acid fermentation clear liquid.2. the citric acid fermentation clear liquid is introduced in the mobile continuous stripping of the simulation system that is made up of the decolorizing column of adorning decoloring material (decolorizing resin or gac) in 5～30 in the mode of following current or adverse current and decoloured the citric acid fermentation broth that obtains decolouring.3. the citric acid fermentation broth of decolouring is introduced the removal of carrying out zwitterion in the mobile demineralization of the simulation system that forms by dress anionite-exchange resin in 4～30 with by dress Zeo-karb in 4～30, the citric acid fermentation broth of the mineral substance that is removed in the mode of following current or adverse current.4. the citric acid fermentation broth after above-mentioned operation being handled is introduced in the chromatographic fractionation system of being made up of dress selective separation resin in 4～30 in the mode of following current or adverse current, with in the sodium hydroxide with directly generate Trisodium Citrate and make it to separate with various liquid magazines in the fermented liquid, obtain the sodium citrate solution that purified concentration is 20%-40%.5. the sodium citrate solution of purifying is carried out concentrating under reduced pressure crystallization, centrifugal and dry in condensing crystal, centrifugal and drying plant, obtain meeting the Trisodium Citrate product of national standard, mother liquor returns separation circuit to be separated again.
The parting material of loading in the chromatographic fractionation system of the present invention is for having the anionite-exchange resin of selective separation effect to Trisodium Citrate.
Used fermented liquid can be that its main component is through the microorganism citric acid fermentation broth that fermentation produces to different material in the extracting method of the present invention:
Citric acid 5%-20%
Carbohydrate 0.2%-1.0%
Inorganic salt 0.1%-0.8%
Foreign protein and amino acid～5%
Mycelium 5%-8%
Extracting method of the present invention is compared with other relevant technologies has following advantage:
1, directly from fermented liquid, extracts the Trisodium Citrate product.
2, compare with ion exchange method, need not to add again desaccharification agent removal of impurities in the parting liquid, directly concentrate and obtain qualified product.
3, extract the Trisodium Citrate product than double decomposition, can reduce cost 20%.
4, leaching process does not produce liquid-solid attitude waste material.Therefore, environment is not polluted.
Embodiment: 5 liters of fermented with dry sweet potato clear liquids (containing citric acid 450 grams) after the press filtration; The decolouring system is made up of 5 activated carbon columns (2 centimetres of diameters, long 40 centimetres); The demineralization system is made up of the exchange column (2 centimetres of diameters, long 40 centimetres) of dress anion-cation exchange resin in 8; Chromatographic fractionation system is made up of the separator column (2 centimetres of diameters, long 40 centimetres) of the resin of Trisodium Citrate tool selective separation effect dress in 20.
Separating step:
1. at first the flow velocity of 5 liters of fermented liquids introducing activated carbon columns with 6 milliliters of per minutes decoloured, collect 6.0 liters of decolouring secondary fermentation liquid (containing citric acid 447 grams).
2. the fermented liquid after will decolouring is introduced the demineralization system to remove various hetero-ions in the fermented liquid with the flow velocity of 6 milliliters of per minutes, collects 6 liters of effluent liquid (containing citric acid 445 grams).
3. will slough 6 liters of citric acid fermentation broths of various hetero-ions and introduce chromatographic fractionation system with the flow velocity of 6 milliliters of per minutes, introduce the sodium hydroxide of clear water and 10% again and remove readily carbonizable substances such as residual sugar, collect and separate 2.2 liters of back 28.3% sodium citrate solutions (containing Trisodium Citrate 623 grams) of purifying.
4. the sodium citrate solution of purifying is moved to concentrating under reduced pressure in the thickening equipment, occur moving to the centrifugation apparatus solid-liquid separation after the crystallization, mother liquor (containing 30% Trisodium Citrate) is concentrated or return separation system separation and purification more again, and the wet crystal of Trisodium Citrate after centrifugal obtains final Trisodium Citrate product 600 grams after drying.
According to the foregoing description estimation, adopt the inventive method to produce Trisodium Citrate yield＞95%.Examination and test of products result meets the quality standard requirement.Assay is as follows:
Claims (4)
1. from citric acid fermentation broth, extract the production technique of Trisodium Citrate, comprise following operation: the press filtration of (1) citric acid fermentation broth, the decolouring of (2) pressing filtering liquid, (3) pressing filtering liquid demineralization, (4) Trisodium Citrate generates and chromatographic separation, and (5) Trisodium Citrate purification liquid concentrates, crystallization and product drying; It is characterized in that in operation (4) citric acid and sodium hydroxide directly generates Trisodium Citrate and dress selective separation resin is formed in by 4～30 chromatographic fractionation system in obtain purifying.
2. technology according to claim 1 is characterized in that clear liquid after the citric acid fermentation broth press filtration is to adorn in the mobile continuous stripping of the simulation system that the decolorizing column of decoloring material (decolorizing resin or gac) forms to decolour in by 5～30.
3. technology according to claim 1, the pressing filtering liquid after it is characterized in that decolouring are to adorn anionite-exchange resin and adorn the positive removal of zwitterion of carrying out in the mobile demineralization of the simulation of forming in exchange resin system in by 4～30 in 4～30.
4. technology according to claim 1, it is characterized in that to the Trisodium Citrate purification liquid that obtains through operation (4) in the thickening equipment of operation (5), concentrate, crystallization.Concentrated solution after the crystallization drains in the whizzer centrifugal, and the mother liquor after centrifugal is back to operation (4) to be separated again, and the wet crystal of Trisodium Citrate is delivered to and obtained qualified product in the drying plant after the drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98101098A CN1192474A (en) | 1998-03-24 | 1998-03-24 | Prodn. process for extracting sodium citrate from citric acid fermentation liquor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98101098A CN1192474A (en) | 1998-03-24 | 1998-03-24 | Prodn. process for extracting sodium citrate from citric acid fermentation liquor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1192474A true CN1192474A (en) | 1998-09-09 |
Family
ID=5216464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98101098A Pending CN1192474A (en) | 1998-03-24 | 1998-03-24 | Prodn. process for extracting sodium citrate from citric acid fermentation liquor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1192474A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101407454B (en) * | 2007-10-13 | 2011-09-07 | 黄石兴华生化有限公司 | Process for preparing citrate salt from mother liquor for citric acid production |
| CN102260164A (en) * | 2010-05-24 | 2011-11-30 | 安徽丰原生物化学股份有限公司 | Separating method of citric acid |
| CN102731294A (en) * | 2012-07-23 | 2012-10-17 | 国药集团化学试剂有限公司 | Preparation method of sodium citrate |
| CN107089909A (en) * | 2016-02-18 | 2017-08-25 | 姚鼎文 | The method that melamine complex salt crystal method directly manufactures sodium citrate, potassium citrate and ammonium citrate from citric acid fermentation broth |
| CN107935838A (en) * | 2017-12-01 | 2018-04-20 | 宁乡新阳化工有限公司 | The preparation method and preparation system of one sodium of anhydrous citric acid |
| CN114790467A (en) * | 2022-06-06 | 2022-07-26 | 杭州鸿满化工有限公司 | Citric acid fermentation process |
-
1998
- 1998-03-24 CN CN98101098A patent/CN1192474A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101407454B (en) * | 2007-10-13 | 2011-09-07 | 黄石兴华生化有限公司 | Process for preparing citrate salt from mother liquor for citric acid production |
| CN102260164A (en) * | 2010-05-24 | 2011-11-30 | 安徽丰原生物化学股份有限公司 | Separating method of citric acid |
| CN102731294A (en) * | 2012-07-23 | 2012-10-17 | 国药集团化学试剂有限公司 | Preparation method of sodium citrate |
| CN102731294B (en) * | 2012-07-23 | 2015-06-17 | 国药集团化学试剂有限公司 | Preparation method of sodium citrate |
| CN107089909A (en) * | 2016-02-18 | 2017-08-25 | 姚鼎文 | The method that melamine complex salt crystal method directly manufactures sodium citrate, potassium citrate and ammonium citrate from citric acid fermentation broth |
| CN107935838A (en) * | 2017-12-01 | 2018-04-20 | 宁乡新阳化工有限公司 | The preparation method and preparation system of one sodium of anhydrous citric acid |
| CN107935838B (en) * | 2017-12-01 | 2020-09-08 | 宁乡新阳化工有限公司 | Preparation method and preparation system of anhydrous monosodium citrate |
| CN114790467A (en) * | 2022-06-06 | 2022-07-26 | 杭州鸿满化工有限公司 | Citric acid fermentation process |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111647027B (en) | Method for separating and purifying N-acetylglucosamine | |
| CN102596800B (en) | Fractionation of a waste liquor stream from nanocrystalline cellulose production | |
| CN100339364C (en) | Method for extracting natural taurine from octopus residue using membrane separation technology | |
| CN1187854A (en) | Process for producing calcium D-pantothenate | |
| CN101182079B (en) | Citric acid mother liquor treatment process | |
| US5002614A (en) | Process for extracting lipids (cane wax) from sugar cane molassas | |
| CN1301331C (en) | Method for extracting fermentikve macrolide antibiotics using membrane | |
| CN1192474A (en) | Prodn. process for extracting sodium citrate from citric acid fermentation liquor | |
| CN101870639A (en) | Method for producing kelp mannitol with low energy consumption | |
| CN1302175C (en) | Method for separating and purifying Nano bacteria cellulose | |
| CN1105980A (en) | Method of extracting citric acid from citric acid fermentation liquor | |
| JPH02275835A (en) | Method for recovering citric acid from solution containing citric acid | |
| CN1056191C (en) | Trisodium citrate preparing process using anion exchange resin | |
| CN212560056U (en) | System for utilize simulated moving bed to extract L-isoleucine | |
| CN211921110U (en) | Device for efficiently utilizing components of corn soaking water | |
| CN1554662A (en) | Process for preparing high purity acarbose | |
| Atkinson et al. | Development of downstream processing | |
| CN1060522C (en) | Process for separating and purifying citric acid | |
| CN1081617C (en) | Method for prodn. of glycerin by using waste liquor from saponification process | |
| CN1158836A (en) | Refined glycerine prepared with fermented glycerine solution and its refinement process and equipment | |
| CN221479922U (en) | Production device of sodium glucuronate | |
| CN1099746A (en) | Method for extracting glutamic acid from fermentation liquor | |
| CN1259295C (en) | Process for extracting mannitol from kelp soak solution by membrane method | |
| SK69795A3 (en) | Method of producing alpha, alpha-trehaloze | |
| RU2022018C1 (en) | Continuous method for extraction of betaine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Zhao Lixin Document name: Notification before expiration of term |
|
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Zhao Lixin Document name: payment instructions |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |