CN119032099A - 纯化产品的方法 - Google Patents

纯化产品的方法 Download PDF

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Publication number
CN119032099A
CN119032099A CN202380033420.7A CN202380033420A CN119032099A CN 119032099 A CN119032099 A CN 119032099A CN 202380033420 A CN202380033420 A CN 202380033420A CN 119032099 A CN119032099 A CN 119032099A
Authority
CN
China
Prior art keywords
protein
antibody
affinity chromatography
eluate
buffer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380033420.7A
Other languages
English (en)
Chinese (zh)
Inventor
安德里亚斯·塞巴斯蒂安·楚尔布里根
卡罗尔·印-阿尔本
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KO DA Pharmaceutical Co Ltd
Original Assignee
KO DA Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KO DA Pharmaceutical Co Ltd filed Critical KO DA Pharmaceutical Co Ltd
Publication of CN119032099A publication Critical patent/CN119032099A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN202380033420.7A 2022-02-10 2023-02-09 纯化产品的方法 Pending CN119032099A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263267810P 2022-02-10 2022-02-10
US63/267,810 2022-02-10
PCT/US2023/062322 WO2023154822A2 (en) 2022-02-10 2023-02-09 Methods of purifying a product

Publications (1)

Publication Number Publication Date
CN119032099A true CN119032099A (zh) 2024-11-26

Family

ID=87521638

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380033420.7A Pending CN119032099A (zh) 2022-02-10 2023-02-09 纯化产品的方法

Country Status (10)

Country Link
US (1) US20230250133A1 (https=)
EP (1) EP4476237A2 (https=)
JP (1) JP2025505696A (https=)
KR (1) KR20240142564A (https=)
CN (1) CN119032099A (https=)
AU (1) AU2023217074A1 (https=)
CA (1) CA3251000A1 (https=)
IL (1) IL314472A (https=)
MX (1) MX2024009755A (https=)
WO (1) WO2023154822A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119454939A (zh) * 2024-11-28 2025-02-18 北海康成(苏州)生物制药有限公司 一种欧莫扑拜单抗原液及其制备方法
CN119524125A (zh) * 2024-11-28 2025-02-28 北海康成(苏州)生物制药有限公司 一种欧莫扑拜单抗原液的生产方法及欧莫扑拜单抗原液

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* Cited by examiner, † Cited by third party
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WO2015035342A2 (en) 2013-09-08 2015-03-12 Oligasis Llc Factor viii zwitterionic polymer conjugates
CA3059938A1 (en) 2017-04-14 2018-10-18 Kodiak Sciences Inc. Complement factor d antagonist antibodies and conjugates thereof
EP3758737A4 (en) 2018-03-02 2022-10-12 Kodiak Sciences Inc. IL-6 ANTIBODIES AND FUSION CONSTRUCTS AND CONJUGATES THEREOF
CA3157509A1 (en) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Methods of treating an eye disorder
WO2025073922A1 (en) * 2023-10-04 2025-04-10 Sartorius Bia Separations D.O.O. Enhanced chromatographic separations of components in a mixture by employing chaotropic elution
WO2025184423A1 (en) * 2024-02-29 2025-09-04 Kodiak Sciences Inc. Cell-surface-targeting-domain-polymer-payload conjugate
WO2026055308A1 (en) * 2024-09-06 2026-03-12 Merck Sharp & Dohme Llc Multivalent fzd4, wnt co-receptor, and vegf receptor molecules and uses thereof
US20260092125A1 (en) * 2024-09-06 2026-04-02 Eyebiotech Limited Multivalent fzd4, wnt co-receptor, and vegf binding molecules and uses thereof
WO2026075981A1 (en) * 2024-10-01 2026-04-09 Regeneron Pharmaceuticals, Inc. Methods of analyzing heterodimeric proteins

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7045314B2 (en) * 2000-04-04 2006-05-16 Baxter International Inc. Method for the production of bacterial toxins
WO2010147686A2 (en) * 2009-03-11 2010-12-23 Wyeth Llc Methods of purifying small modular immunopharmaceutical proteins
JP6162707B2 (ja) * 2011-10-24 2017-07-12 ハロザイム インコーポレイテッド 抗ヒアルロナン剤治療のためのコンパニオン診断およびその使用方法
CN105899540B (zh) * 2014-01-03 2020-02-07 豪夫迈·罗氏有限公司 双特异性抗-半抗原/抗-血脑屏障受体的抗体、其复合物及它们作为血脑屏障穿梭物的应用
MX380658B (es) * 2014-01-15 2025-03-11 Hoffmann La Roche Variantes de region fc con union mejorada de la proteina a.
EP3054007A1 (en) * 2015-02-09 2016-08-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Recombinant adeno-associated virus particle purification comprising an immuno-affinity purification step
PE20181363A1 (es) * 2015-09-23 2018-08-27 Genentech Inc Variantes optimizadas de anticuerpos anti-vegf
KR20250057128A (ko) * 2015-12-30 2025-04-28 코디악 사이언시스 인코포레이티드 항체 및 이의 접합체
EP3758737A4 (en) * 2018-03-02 2022-10-12 Kodiak Sciences Inc. IL-6 ANTIBODIES AND FUSION CONSTRUCTS AND CONJUGATES THEREOF
US20210254073A1 (en) * 2020-02-04 2021-08-19 Cornell University Methods for capture and analysis of macromolecular complexes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119454939A (zh) * 2024-11-28 2025-02-18 北海康成(苏州)生物制药有限公司 一种欧莫扑拜单抗原液及其制备方法
CN119524125A (zh) * 2024-11-28 2025-02-28 北海康成(苏州)生物制药有限公司 一种欧莫扑拜单抗原液的生产方法及欧莫扑拜单抗原液

Also Published As

Publication number Publication date
CA3251000A1 (en) 2023-08-17
KR20240142564A (ko) 2024-09-30
JP2025505696A (ja) 2025-02-28
MX2024009755A (es) 2024-08-20
IL314472A (en) 2024-09-01
WO2023154822A2 (en) 2023-08-17
AU2023217074A1 (en) 2024-08-15
WO2023154822A3 (en) 2023-09-21
EP4476237A2 (en) 2024-12-18
WO2023154822A8 (en) 2024-04-04
US20230250133A1 (en) 2023-08-10

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