CN1189221C - Endosteal planting body for guiding bone tissue into growth and its preparation method - Google Patents
Endosteal planting body for guiding bone tissue into growth and its preparation method Download PDFInfo
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- CN1189221C CN1189221C CN 03128139 CN03128139A CN1189221C CN 1189221 C CN1189221 C CN 1189221C CN 03128139 CN03128139 CN 03128139 CN 03128139 A CN03128139 A CN 03128139A CN 1189221 C CN1189221 C CN 1189221C
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- tricalcium phosphate
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- bone cement
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Abstract
The present invention relates to an endosteal implant and a preparation method thereof. The endosteal implant for guiding the growth of bone tissues comprises a metal base body, wherein a cavity or a mechanical inlaying structure is arranged on the metal base body. The present invention is characterized in that the cavity or the mechanical inlaying structure on the metal base body is filled with degradable biological materials; a bioactive coating is coated on the surface of the metal base body; the degradable biological materials are absorbable inorganic bioactive bone cement or the composite material of beta-tricalcium phosphate and the absorbable inorganic bioactive bone cement or polylactic acid and beta-tricalcium phosphate or the beta-tricalcium phosphate and collagen or absorbable biocolloid and the beta-tricalcium phosphate. The present invention has a simple preparation method. New bones can be grown into the cavity of the endosteal implant from host bones along an interface filled with the degradable biological materials so as to realize firm mechanical fixation.
Description
Technical field
The present invention relates to a kind of endosteal implant and preparation method thereof.
Background technology
At present, in the load-bearing bone substitution material, metal material occupies an important position.But the common problem that metal endosteal implant ubiquity is loosening and plantation is not firm is become flexible and is sunk as artificial joint and normal generation of tooth implant, causes to implant and loses efficacy.Existing technology mainly contains two kinds of methods: 1, Purely mechanical is fixed, adopt matsurface (as: screw thread, groove, hole, chamber and projection etc.) as implant surface, because existing sophisticated coating technology (as plasma spraying) can not be carried out coating in the implant surface of complicated shape, therefore, this type of implantation body usually adopts Purely mechanical to fix, and still easily produces loosening; 2, pure biological fixation, as the artificial joint of the plasma spraying bioactivity coatings of present employing and tooth implant etc., this type coating often is coated in even curface, because the fixed assistance of no mechanical type, cause implant surface often to be in the high stress environment of pure shear, also be easy to cause the coating later stage to come off.Therefore, solve the stable problem of metal endosteal implant mainly from both direction: the one, the development of new coating technology than complicated shape metal surface preparation biological activity and the suitable bonded coating of biological stability, improves implantation body's biological fixation dynamics.The 2nd, solve the mechanical type fixation problem.
In tooth implant and artificial joint, the implantation body of some type adopts hole, chamber (hole) formula mechanical means.Desire produces firm mechanical bond, and necessary inducting osseous tissue is in the regeneration of inside, hole, chamber.The regeneration of inducting osseous tissue is exactly to make an environment and the space can be grown osseous tissue therein, stops the composition that can cause soft tissue simultaneously; Move to the position of estimating that bone is grown into as fibroblast.Set out with this notion, be scheduled to wish the spatial reservation that bone is grown into and keep to be the overriding concern problem.But design of present lumen pore and implantation technology can not reach ideal mechanical fixation when practical application, after reason is that implantation body implants, the hole, chamber can not produce with bone and contact closely, thereby by the filling of soft tissue institute, so can not guide bone hole, the chamber generation mechanical fixation of growing into.Degradable biomaterial has good biocompatibility, bone conductibility and biological degradability, can dissolve disappearance gradually after implanting, and is replaced by lived freshman bone tissue.
Summary of the invention
The object of the present invention is to provide a kind of can be after implanting the inducting osseous tissue hole, chamber of growing into gradually, thereby realize the endosteal implant of firm mechanical bond; And the preparation method of endosteal implant.
To achieve these goals, technical scheme of the present invention is: the endosteal implant that inducting osseous tissue is grown into, it comprises metallic matrix, metallic matrix is provided with hole, chamber or cast setting structure, it is characterized in that in the hole, chamber on the metallic matrix (the surface-coated bioactivity coatings is better) or the interior filling degradable biomaterial of mosaic texture, degradable biomaterial is one of following material: 1) can absorb the inorganic bioactivity bone cement, 2) bata-tricalcium phosphate and can absorb the inorganic bioactivity bone cement, 3) polylactic acid and bata-tricalcium phosphate composite, 4) bata-tricalcium phosphate and collagen; Wherein, can absorb the inorganic bioactivity bone cement: the mass ratio of bata-tricalcium phosphate=1～2: 1, polylactic acid: the mass ratio of bata-tricalcium phosphate composite=6～8: 1, collagen: the mass ratio of bata-tricalcium phosphate=6～8: 1.
Described metal base surface applies bioactivity coatings, and described bioactivity coatings is an one of the following: 1) pure ha coating, 2) hydroxyapatite and bio-vitric composite coating, 3) the biological glass ceramic coating.
The preparation method of the endosteal implant that inducting osseous tissue is grown into, it is characterized in that comprising the steps: 1), metallic matrix begin to speak hole or cast setting structure, utilizing the multistep electrophoretic deposition---sintering, biosimulation are soaked, the spraying physico-chemical process prepares bioactivity coatings at metal base surface, described bioactivity coatings is an one of the following: a) pure ha coating, b) hydroxyapatite and bio-vitric composite coating c) the biological glass ceramic coating; 2), choose one of following material of degradable biomaterial: a) can absorb the inorganic bioactivity bone cement, b) bata-tricalcium phosphate and can absorb the inorganic bioactivity bone cement, c) polylactic acid and bata-tricalcium phosphate composite, d) bata-tricalcium phosphate and collagen; Wherein, can absorb the inorganic bioactivity bone cement: the mass ratio of bata-tricalcium phosphate=1～2: 1, polylactic acid: the mass ratio of bata-tricalcium phosphate composite=6～8: 1, collagen: the mass ratio of bata-tricalcium phosphate=6～8: 1, modulation degradable biomaterial slurry; With slurry: H
2O
2Volume ratio=3～4: 1 ratio is added H in slurry
2O
2, at last with hole, chamber or cast setting structure on the slurry shutoff metallic matrix for preparing; Foamable, curing; 3), degradable biomaterial solidifies and to finish, cleaning filler surface makes it smooth, encapsulates stand-by.
The present invention has utilized the biocompatibility of some biomaterial, biological degradability and bone guided.Behind Biodegradable material or the bioabsorbable material implantable bone tissue, material is by body fluid dissolving and cell-mediated biodegradation, a part participates in the bone reconstruction that bone is implanted part or far-end, another part is excreted by metabolic system gradually, defect is substituted by new life's osseous tissue fully, and the Biodegradable material of implantation body only play the falsework effect.The present invention utilizes degradability biomaterial filling plantation body cavity hole or cast setting structure to guarantee that implantation body implants the back osseous tissue shape space, hole, chamber of growing into gradually.Its principle be the male and female face of implantation body by shutoff after, can avoid the gathering of soft tissue at place, hole, chamber, guaranteed that implantation body contacts with the tight of osseous tissue.The place that contacts with osseous tissue in implantation body, because the combined effect of osteoblast and osteoclast, when the degradation material of institute's filling was degraded gradually, new bone was grown into from host bone along the filler interface and is planted in body cavity hole or the cast setting structure, realizes firm mechanical fixation.As shown in Figure 1 and Figure 2.
Description of drawings
Fig. 1 is the cross section structure sketch map before the present invention implants
Fig. 2 is the grow into cross section structure sketch map in hole, chamber of inducting osseous tissue gradually after the present invention implants
Fig. 3 is the cross section structure sketch map of the embodiment of the invention 1
Fig. 4 is the embodiment of the invention 2 joint handles surface Margarita face and shutoff face structural representation
Fig. 5 is the embodiment of the invention 2 osseous tissues Margarita face structural representations of growing into
Wherein 1-metallic matrix, 2-degradable biomaterial, 3-osseous tissue, 4-Margarita face, 5-shutoff face.
The specific embodiment
Key problem in technology of the present invention: at first select suitable degradability biomaterial, selected packing material can be complementary with the metallic matrix of institute shutoff on mechanical performance, realize complete shutoff to Metal Substrate body cavity hole or cast setting structure; Component, aperture, pore structure and distributed pores rate, the degradation speed of control cavity packing material system, thus the control osseous tissue is grown into speed to satisfy the requirement of different implant sites to material degradation speed.To the hole, chamber that different implant sites and instructions for use design is dissimilar dark/wide ratio.
From with metallic matrix mechanical performance coupling, biological degradability and bone guided aspect of performance are selected filler, make it tight filling within the hole, chamber, and with the hole, chamber certain binding ability are arranged, and avoid in implantation process the coming off of charges.Charges should have excellent biological compatibility, biodegradability and bone guided, the regeneration of inducting osseous tissue that can be faster after in implanting.The degradation rate of filler should be complementary with the growth rate of new bone.The degradable biomaterial system of Gong selecting for use that meets above requirement has:
1, can absorb inorganic bioactivity bone cement (α-TCP)
2, bata-tricalcium phosphate (β-TCP)+can absorb inorganic bioactivity bone cement (α-TCP)
3, polylactic acid/β-TCP composite
4, β-TCP+ collagen
5, absorbable biological glue+β-TCP
The degradation rate of control filler, not only relevant, also relevant with preparation technology with the material self characteristics.Therefore, should be by pore structure, aperture, pore size distribution and the porosity of suitable technical process control filler.According to the performance of different degradable material systems, selecting for use can be 40-50 ℃ of volatilization, and residuals is water or does not have residual material as foaming agent.Alternative foaming agent has H
2O
2, ether etc.By different pore structure requirements, select different foaming agent and addition for use, after reconciling into the degradable material slurry, carry out filling, foamable and curing.Requirement according to different implant site degradable biomaterials and osseous tissue effect situation and mechanical fixation mechanical property aspect, design different hole, chamber types and dark/wide ratio, make the chamber hole metal matrix of institute's filling that the suitable bone amount of growing into be arranged in the time in clinical permission after the implantation.
Embodiment 1: as shown in Figure 3.
Adopt the degradable biomaterial blocking technology, preparation bone cement shutoff composite coating titanium alloy with holes tooth implant.Concrete technology is as follows:
1, the preparation of the titanium alloy tooth root planting body of coating
Adopt a segment body formula dental implant, screw-type cylinder, butt have the hole of lateral penetration cylinder, as shown in Figure 3.Utilizing the multistep electrophoretic deposition---sintering technology prepares hydroxyapatite/bio-vitric composite coating.
2, press bone cement: β-tricalcium phosphate (mass ratio)=2: 1, modulation can absorb inorganic bioactivity bone cement and β-tricalcium phosphate (TCP) mixed slurry; With slurry: H
2O
2(volume ratio)=3: 1 adds H in slurry
2O
2At last with the slurry shutoff tooth implant butt hole for preparing.
3, be heated to 50 ℃, treat H
2O
2Decomposition and cement solidification finish, and cleaning filler surface makes it smooth; Implantation body's encapsulation is stand-by.
Embodiment 2: as Fig. 4, shown in Figure 5.
Adopt the degradable biomaterial blocking technology, the artificial joint implantation body of preparation bone cement shutoff surface Margarita face.
Concrete technology is as follows:
1, in titanium alloy joint handle metallic matrix suitable position casting surface Margarita face structure, as shown in Figure 4.
2, modulation can absorb the inorganic bioactivity bone cement (slurry of α-TCP); With slurry: H
2O
2(volume ratio)=3: 1 adds H in slurry
2O
2With the slurry shutoff titanium alloy joint handle surface Margarita face structure for preparing, make its surfacing at last.
3, be heated to 50 ℃, treat H
2O
2After decomposition and slurry formed the porous firming body, cleaning filler surface made it smooth; Implantation body's encapsulation is stand-by.
Claims (3)
1. the inducting osseous tissue endosteal implant of growing into, it comprises metallic matrix, metallic matrix is provided with hole, chamber or cast setting structure, it is characterized in that: in the hole, chamber on the metallic matrix or mosaic texture in the filling degradable biomaterial, degradable biomaterial is one of following material: 1) can absorb the inorganic bioactivity bone cement, 2) bata-tricalcium phosphate and can absorb inorganic bioactivity bone cement, 3) polylactic acid and bata-tricalcium phosphate composite, 4) bata-tricalcium phosphate and collagen; Wherein, can absorb the inorganic bioactivity bone cement: the mass ratio of bata-tricalcium phosphate=1～2: 1, polylactic acid: the mass ratio of bata-tricalcium phosphate composite=6～8: 1, collagen: the mass ratio of bata-tricalcium phosphate=6～8: 1.
2, the inducting osseous tissue according to claim 1 endosteal implant of growing into, it is characterized in that described metal base surface applies bioactivity coatings, described bioactivity coatings is an one of the following: 1) pure ha coating, 2) hydroxyapatite and bio-vitric composite coating, 3) the biological glass ceramic coating.
3, the preparation method of the inducting osseous tissue endosteal implant of growing into, it is characterized in that comprising the steps: 1), metallic matrix begin to speak hole or cast setting structure, utilizing the multistep electrophoretic deposition---sintering, biosimulation are soaked, the spraying physico-chemical process prepares bioactivity coatings at metal base surface, described metal base surface applies bioactivity coatings, described bioactivity coatings is an one of the following: a) pure ha coating, b) hydroxyapatite and bio-vitric composite coating, c) biological glass ceramic coating; 2), choose one of following material of degradable biomaterial: a) can absorb the inorganic bioactivity bone cement, b) bata-tricalcium phosphate and can absorb the inorganic bioactivity bone cement, c) polylactic acid and bata-tricalcium phosphate composite, d) bata-tricalcium phosphate and collagen; Wherein, can absorb the inorganic bioactivity bone cement: the mass ratio of bata-tricalcium phosphate=1～2: 1, polylactic acid: the mass ratio of bata-tricalcium phosphate composite=6～8: 1, collagen: the mass ratio of bata-tricalcium phosphate=6～8: 1, modulation degradable biomaterial slurry; With slurry: H
2O
2Volume ratio=3～4: 1 ratio is added H in slurry
2O
2, at last with hole, chamber or cast setting structure on the slurry shutoff metallic matrix for preparing; Foamable, curing; 3), degradable biomaterial solidifies and to finish, cleaning filler surface makes it smooth, encapsulates stand-by.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03128139 CN1189221C (en) | 2003-06-11 | 2003-06-11 | Endosteal planting body for guiding bone tissue into growth and its preparation method |
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|---|---|---|---|
| CN 03128139 CN1189221C (en) | 2003-06-11 | 2003-06-11 | Endosteal planting body for guiding bone tissue into growth and its preparation method |
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| CN1189221C true CN1189221C (en) | 2005-02-16 |
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| CN 03128139 Expired - Fee Related CN1189221C (en) | 2003-06-11 | 2003-06-11 | Endosteal planting body for guiding bone tissue into growth and its preparation method |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8529933B2 (en) * | 2009-07-27 | 2013-09-10 | Warsaw Orthopedic, Inc. | Biphasic calcium phosphate cement for drug delivery |
| CN103908328A (en) * | 2013-01-06 | 2014-07-09 | 香港中文大学 | Orthopedic implant |
| CN106618807A (en) * | 2016-11-17 | 2017-05-10 | 中国人民解放军第三军医大学第附属医院 | Detachable talus prosthesis |
| CN106618806A (en) * | 2016-11-17 | 2017-05-10 | 中国人民解放军第三军医大学第附属医院 | Talus prosthesis |
| CN108553187A (en) * | 2018-05-16 | 2018-09-21 | 广州市健齿生物科技有限公司 | A kind of porous dental implant and manufacturing method of internal combination biodegradable magnesium alloy |
| CN115252229B (en) * | 2022-06-28 | 2024-03-19 | 香港中文大学 | Intra-osseous plant |
| CN115252908A (en) * | 2022-09-06 | 2022-11-01 | 西南医科大学附属医院 | Preparation method of composite porous titanium scaffold for increasing new bone ingrowth |
| CN115591015B (en) * | 2022-10-25 | 2024-01-26 | 季华实验室 | Degradable metal/polymer composite bone fracture plate and preparation method thereof |
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