CN118891050A - 用Rho鸟嘌呤核苷酸交换因子12(ARHGEF12)抑制剂治疗青光眼 - Google Patents

用Rho鸟嘌呤核苷酸交换因子12(ARHGEF12)抑制剂治疗青光眼 Download PDF

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Publication number
CN118891050A
CN118891050A CN202280075189.3A CN202280075189A CN118891050A CN 118891050 A CN118891050 A CN 118891050A CN 202280075189 A CN202280075189 A CN 202280075189A CN 118891050 A CN118891050 A CN 118891050A
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China
Prior art keywords
seq
complement
position corresponding
thymine
guanine
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Pending
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CN202280075189.3A
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Chinese (zh)
Inventor
K·普拉文
G·科波拉
M·A·R·费雷拉
L·古尔斯基
A·巴拉斯
C·舒尔曼
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of CN118891050A publication Critical patent/CN118891050A/zh
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
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  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202280075189.3A 2021-09-30 2022-09-28 用Rho鸟嘌呤核苷酸交换因子12(ARHGEF12)抑制剂治疗青光眼 Pending CN118891050A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163250492P 2021-09-30 2021-09-30
US63/250,492 2021-09-30
PCT/US2022/077176 WO2023056295A1 (en) 2021-09-30 2022-09-28 Treatment of glaucoma with rho guanine nucleotide exchange factor 12 (arhgef12) inhibitors

Publications (1)

Publication Number Publication Date
CN118891050A true CN118891050A (zh) 2024-11-01

Family

ID=83996920

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280075189.3A Pending CN118891050A (zh) 2021-09-30 2022-09-28 用Rho鸟嘌呤核苷酸交换因子12(ARHGEF12)抑制剂治疗青光眼

Country Status (9)

Country Link
US (1) US12577562B2 (https=)
EP (1) EP4408535A1 (https=)
JP (1) JP2024535110A (https=)
KR (1) KR20240099232A9 (https=)
CN (1) CN118891050A (https=)
AU (1) AU2022357497A1 (https=)
CA (1) CA3232251A1 (https=)
IL (1) IL311711A (https=)
WO (1) WO2023056295A1 (https=)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003280812A1 (en) * 2002-11-18 2004-06-15 Santen Pharmaceutical Co., Ltd. REMEDY FOR GLAUCOMA COMPRISING Rho KINASE INHIBITOR AND Beta-BLOCKER
US20090264533A1 (en) * 2005-03-30 2009-10-22 Richard Neubig Methods and Compositions for Modulating RHO-Mediated Gene Transcription
AR057252A1 (es) * 2005-12-27 2007-11-21 Alcon Mfg Ltd Inhibicion de rho quinasa mediada por arni para el tratamiento de trastornos oculares
GB201107176D0 (en) 2011-04-28 2011-06-15 Cxr Biosciences Ltd Pyrrolnitrin derivatives
EP3866790A4 (en) * 2018-10-15 2022-08-03 Ocuphire Pharma, Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF GLAUCOMA AND RELATED DISEASES
MX2021008797A (es) * 2019-01-23 2022-01-31 Regeneron Pharma Tratamiento de afecciones oftalmicas con inhibidores de proteinas relacionadas a angiopoyetina 7 (angptl7).

Also Published As

Publication number Publication date
CA3232251A1 (en) 2023-04-06
IL311711A (en) 2024-05-01
KR20240099232A (ko) 2024-06-28
US12577562B2 (en) 2026-03-17
EP4408535A1 (en) 2024-08-07
KR20240099232A9 (ko) 2025-12-10
WO2023056295A1 (en) 2023-04-06
US20230099109A1 (en) 2023-03-30
AU2022357497A1 (en) 2024-04-04
JP2024535110A (ja) 2024-09-26

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