CN118829628A - 哺乳动物slc6a19功能的小分子抑制剂 - Google Patents
哺乳动物slc6a19功能的小分子抑制剂 Download PDFInfo
- Publication number
- CN118829628A CN118829628A CN202280091961.0A CN202280091961A CN118829628A CN 118829628 A CN118829628 A CN 118829628A CN 202280091961 A CN202280091961 A CN 202280091961A CN 118829628 A CN118829628 A CN 118829628A
- Authority
- CN
- China
- Prior art keywords
- compound
- substituted
- alkyl
- cycloalkyl
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163292818P | 2021-12-22 | 2021-12-22 | |
| US63/292818 | 2021-12-22 | ||
| PCT/US2022/053798 WO2023122267A2 (en) | 2021-12-22 | 2022-12-22 | Small molecule inhibitors of mammalian slc6a19 function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118829628A true CN118829628A (zh) | 2024-10-22 |
Family
ID=86903643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280091961.0A Pending CN118829628A (zh) | 2021-12-22 | 2022-12-22 | 哺乳动物slc6a19功能的小分子抑制剂 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20250084054A1 (https=) |
| EP (1) | EP4452943A4 (https=) |
| JP (1) | JP2025500308A (https=) |
| CN (1) | CN118829628A (https=) |
| WO (1) | WO2023122267A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4304586A4 (en) | 2021-03-10 | 2025-04-02 | Jnana Therapeutics Inc. | SMALL MOLECULE INHIBITORS OF MAMMALIAN SLC6A19 FUNCTION |
| CN119522265A (zh) * | 2022-12-12 | 2025-02-25 | 雪佛龙美国公司 | 用于进料至炼油厂单元的废塑料与石油进料的稳定共混物的方法及其制备方法 |
| WO2025196623A1 (en) | 2024-03-21 | 2025-09-25 | Pfizer Inc. | Indole analogs |
| TW202547506A (zh) * | 2024-04-10 | 2025-12-16 | 大陸商長春金賽藥業有限責任公司 | Ｓｌｃ６ａ１９抑制劑化合物、藥物組合物及其製備方法和用途 |
| WO2025217521A1 (en) * | 2024-04-12 | 2025-10-16 | Jnana Therapeutics Inc. | Treating chronic kidney disease with a combination of a slc6a19 inhibitor and a glp-1 agonist |
| US20250346567A1 (en) | 2024-05-13 | 2025-11-13 | Pfizer Inc. | Substituted pyridine and phenyl compounds |
| WO2026038155A1 (en) | 2024-08-16 | 2026-02-19 | Pfizer Inc. | Substituted pyridine compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4304586A4 (en) * | 2021-03-10 | 2025-04-02 | Jnana Therapeutics Inc. | SMALL MOLECULE INHIBITORS OF MAMMALIAN SLC6A19 FUNCTION |
-
2022
- 2022-12-22 JP JP2024537016A patent/JP2025500308A/ja active Pending
- 2022-12-22 CN CN202280091961.0A patent/CN118829628A/zh active Pending
- 2022-12-22 EP EP22912482.1A patent/EP4452943A4/en active Pending
- 2022-12-22 US US18/723,012 patent/US20250084054A1/en active Pending
- 2022-12-22 WO PCT/US2022/053798 patent/WO2023122267A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023122267A3 (en) | 2023-08-03 |
| US20250084054A1 (en) | 2025-03-13 |
| WO2023122267A2 (en) | 2023-06-29 |
| JP2025500308A (ja) | 2025-01-09 |
| EP4452943A2 (en) | 2024-10-30 |
| EP4452943A4 (en) | 2025-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |