CN1187814A - (Het) Aryloxy-, -Thio-, Aminocrotonates, method of preparing them and their use - Google Patents

(Het) Aryloxy-, -Thio-, Aminocrotonates, method of preparing them and their use Download PDF

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CN1187814A
CN1187814A CN96194701A CN96194701A CN1187814A CN 1187814 A CN1187814 A CN 1187814A CN 96194701 A CN96194701 A CN 96194701A CN 96194701 A CN96194701 A CN 96194701A CN 1187814 A CN1187814 A CN 1187814A
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T·格罗特
R·凯斯特恩
B·穆勒
H·萨特尔
A·哈里斯
H·科尼格
E·阿莫尔曼
G·洛恩兹
S·斯特拉斯曼
F·罗尔
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BASF SE
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Abstract

Described are (het)aryloxy-, -thio-, aminocrotonates of formula (I) in which the substituents are defined as follows: U is oxygen, sulphur or amino; V is oxygen, sulphur, amino or alkylamino; X, Y, Z, independently of each other, are =N- or =CR<3>; R<1>, R<2>, independently of each other, are alkyl; R<3> is hydrogen, cyano, nitro, halogen, alkyl, alkyl halide, alkoxy, alkoxy halide, alkylthio or alkylthio halide; R<4> is an organic group bound directly to the main chain or bound via an oxy, mercapto, amino, carboxy or carbonylamino group. The invention also concerns methods of preparing such compounds and their use.

Description

(mixing) aryloxy-,-sulfenyl-and-amino crotonate, its preparation and application
The present invention relates to (mixing) aryloxy of formula I-,-sulfenyl-and-amino crotonate
Figure A9619470100071
Substituting group wherein have following connotation: U be oxygen (O-), sulphur (S-) or amino (NH-); V be oxygen (O-), sulphur (S-), amino (NH-) or alkylamino [N (alkyl)-]; X, Y and Z be independently of each other=N-or=CR 3-; R 1And R 2Be C independently of each other 1-C 4-alkyl; R 3Be hydrogen, cyano group, nitro, halogen, C 1-C 4-alkyl, C 1-C 4-haloalkyl, C 1-C 4-
Alkoxyl group, C 1-C 4-halogenated alkoxy, C 1-C 4-alkylthio and C 1-C 4-halogenated alkylthio; R 4Be one and main structure Direct Bonding or logical peroxy, sulfydryl, amino, carboxyl or carbonylamino
The organic group of group bonding.
The invention further relates to these compounds process for production thereof, contain the application method of this type of compound compositions and control animal pest and harmful fungoid.
Disclose in the literature heteroaryloxy-,-sulfenyl-and-(EP-A 212 859 for Fungicidally active that amino-beta--alkoxy acrylic ester had; EP-A 383 117; EP-A 471 261; EP-A 503436; EP-A 584 625).EP-A 409 369 further disclose the heteroaryloxy of weeding, growth regulating and Fungicidally active-and-amino crotonate (wherein heterocycle or pyrimidine-2-base ring or 1,3,5-triazines-2-basic ring).
The purpose of this invention is to provide and have the active compound of improvement.
We find that this purpose starts the institute's Compound I that defines realization by this paper.In addition, we find its preparation method, contain this type of compound compositions and application method thereof, especially for the application method of control animal pest and harmful fungoid.
The Compound I described method of document by reference obtains.
In the presence of alkali, (" chemical association magazine " 1963,4210) in a manner known way, preferably by the mercaptan of alcohol or corresponding formula IIa and the crotonate reaction of formula III accordingly, obtaining wherein, V is the Compound I of oxygen or sulphur.
Figure A9619470100081
IIa(Y＝O，S)????????????III
Figure A9619470100082
I(V＝O，S)
L in the formula III is the replaceable leavings group of nucleophilic such as halogen for example chlorine, bromine and iodine, or sulfonate radical for example trifluoromethane sulfonic acid root, Phenylsulfonic acid root and p-methyl benzenesulfonic acid root.
Be reflected at 0 ℃ to 200 ℃, preferred 0 ℃ to 150 ℃, particularly 10 ℃ are carried out in inert solvent or thinner routinely to 100 ℃.
The solvent and the thinner that are fit to are aliphatic hydrocrbon such as pentane, hexane, hexanaphthene and sherwood oil, aromatic hydrocarbons such as toluene, adjacent, between and p-Xylol, halohydrocarbon such as methyl chloride, chloroform and chlorobenzene, ethers such as diethyl ether, diisopropyl ether, t-butyl methyl ether diox, methyl-phenoxide and tetrahydrofuran (THF), nitrile such as acetonitrile and propionitrile, ketone such as acetone, methylethylketone, diethyl ketone and tertiary butyl methyl ketone, alcohols such as methyl alcohol, ethanol, n-propyl alcohol, Virahol, the propyl carbinol and the trimethyl carbinol, and dimethyl sulfoxide (DMSO) and dimethyl formamide, preferred especially acetonitrile, dimethyl formamide, dimethyl sulfoxide (DMSO) and 1,3-dimethyl tetrahydro-2 (IH) pyrimidone (DMPU).Also can use the mixture of the solvent of being mentioned.
The alkali that is fit to generally is mineral compound such as alkali metal hydroxide and alkaline earth metal hydroxides such as lithium hydroxide, sodium hydroxide, potassium hydroxide and calcium hydroxide, basic metal and alkaline earth metal oxide such as Lithium Oxide 98min, sodium oxide, calcium oxide and magnesium oxide, basic metal and alkaline earth metal hydride such as lithium hydride, sodium hydride, potassium hydride KH and hydrolith, alkali metal ammonia compound such as lithamide, ammonification sodium and ammonification potassium, alkaline carbonate and alkaline earth metal carbonate such as Quilonum Retard and lime carbonate, and alkali metal hydrocarbonate such as sodium bicarbonate, organometallic compound, particularly alkali alkyl such as lithium methide, butyllithium and phenyl lithium, magnesium alkyl halide such as methylmagnesium-chloride and alkali metal alcoholate or alkaline-earth metal alcoholate such as sodium methylate, sodium ethylate, potassium ethylate, potassium tert.-butoxide and dimethoxy magnesium, also has organic bases in addition, for example, tertiary amine such as Trimethylamine 99, triethylamine, triisopropyl ethylamine and N-methyl piperidine, pyridine, the pyridine such as the collidine that replace, lutidine and 4-dimethylaminopyridine, and dicyclo amine.
Particularly preferably be salt of wormwood, potassium hydroxide and sodium bicarbonate.
Alkali generally is equimolar amount, excessive or can be used as solvent if desired and use.
Starting raw material normally reacts to each other with equimolar amount.With III is benchmark, adopts excessive or insufficient amount, for yield, perhaps can be favourable.
Required starting raw material formula IIa is known by document for the preparation Compound I, maybe can with known with prepare independent radicals R 4The relevant reported method that is associated of description synthetic.
The starting raw material formula III that preparation equally also needs is by known [" the organic chemistry magazine " 44,2608 (1979) of document; The chemistry magazine PTI of association 21,2651 (1993)] and the method by these document descriptions obtain.
Wherein V is that the Compound I of amino or alkylamino can in the presence of protonic acid, preferably be reacted acquisition by the α-ketone carbonyl compound with corresponding formula IIb amine and formula IV by known mode itself.
Figure A9619470100101
IIb (V=NH, N-alkyl) IV I (V=NH, N-alkyl)
Be reflected at 0 ℃ to 200 ℃, preferred 0 ℃ to 150 ℃, special 10 ℃ are carried out in inert solvent or thinner routinely to 100 ℃.
The solvent and the thinner that are fit to are aliphatic hydrocrbon such as pentane, hexane, hexanaphthene and sherwood oil, aromatic hydrocarbons such as toluene, neighbour, and p-Xylol, halohydrocarbon such as methyl chloride, chloroform and chlorobenzene, ethers such as diethyl ether, diisopropyl ether, t-butyl methyl ether, diox, methyl-phenoxide and tetrahydrofuran (THF), nitrile such as acetonitrile and propionitrile, ketone such as acetone, methylethylketone, diethyl ketone and tertiary butyl methyl ketone, alcohols such as methyl alcohol, ethanol, n-propyl alcohol, Virahol, propyl carbinol and the trimethyl carbinol, and dimethyl sulfoxide (DMSO) and dimethyl formamide, preferred especially toluene.
Also can use the mixture of the solvent of being mentioned.
Used protonic acid is mineral acid such as hydrofluoric acid, hydrochloric acid, Hydrogen bromide, sulfuric acid and crosses chloric acid, and organic acid such as formic acid, acetate, trifluoroacetic acid, propionic acid, oxalic acid, citric acid and trifluoroacetic acid.
Acid is used with catalytic amount usually, but they also can be with equimolar amount, excessive or use as solvent if desired.
Starting raw material normally reacts to each other with equimolar amount.With IV is benchmark, adopts II excessive or in shortage, for yield, perhaps can be favourable.
Required starting raw material formula IIb is known by document for the preparation Compound I, maybe can synthesize with the method for the relevant report of the description associated of the independent radicals R 4 of known and preparation.
Known [Helv.Chim.Acta 30,1372 (1974) by document for the starting raw material formula III that equally also needs of preparation; " organic chemistry magazine " 43,4245 (1978); " biological chemistry " 10,2669 (1971)], maybe can obtain by the method for these document descriptions.
The aftertreatment of this reaction mixture is carried out with usual manner, for example by mixing with water, separates different phases, and if desired crude product is carried out chromatogram purification.In some cases, intermediate that is obtained and end product are colourless or little brown viscosity oily matter forms, their non-volatility components, or under reduced pressure with at the down purifying of heating a little.If the intermediate and the end product that obtain are solids, purifying also can be undertaken by recrystallization or digestion.
Radicals R 4Synthetic can independent above-mentioned conjugates, and depend on radicals R 4Character.For more succinct, in the reaction formula below ,-V-C (COUR 4)=CH-R 2Or its precursor is abbreviated as R #
R wherein 4Can begin by corresponding methyl or alkylate (I.1) in the routine of Compound I is synthetic by carbon atom bonding, and I.2 Compound I .1 is at first obtained corresponding benzyl halide by halo] referring to applied chemistry 71,349 (1959)].
Figure A9619470100121
This halogenating reaction in inert solvent, or in the presence of free radical initiator such as dibenzoyl peroxide or Diisopropyl azodicarboxylate, or at UV irradiation as with under the mercury vapor lamp, at 0 ℃ to 100 ℃, preferred 20 ℃ to 80 ℃ following routines are carried out.
The solvent that is fit to is aliphatic hydrocrbon such as pentane, hexane, hexanaphthene and sherwood oil, aromatic hydrocarbons such as toluene, neighbour, and p-Xylol, halohydrocarbon such as methyl chloride, chloroform and chlorobenzene, ethers such as ether, diisopropyl ether, t-butyl methyl ether, diox, methyl-phenoxide and tetrahydrofuran (THF), preferred especially hexanaphthene, methyl chloride and tetracol phenixin.Also can use the mixture of the solvent of being mentioned.
As the material of halogenating agent be, for example, the element halogen (as, Cl 2, Br 2, I 2), N-bromo-succinimide, N-neoprene imide or two brooethyl hydrantoin.Halogenating agent is generally with equimolar amount, excessive or use as solvent.
Compound I .2 (wherein Hal is an iodine) in addition can be with known mode itself, is reacted with iodide (for example sodium iodide) by muriate or bromide in acetone and prepares [the chemical magazine PTI of association, 416 (1976)].
Benzyl halide is as the center intermediate for preparing a large amount of Compound I by following reaction formula.B.1 R 4=the alkyl that do not replace or replace
I.2 react with nucleophilic reagent by benzyl halide, preferred N-, O-or S-nucleophilic reagent for example react with ethanol, carboxylic acid, mercaptan or amine, obtain corresponding ether, ester, thioether or amine I.4.
Figure A9619470100131
In molecular formula, W *Be oxygen, sulphur, amino or alkylamino; A 1Be alkyl, the acyl group that does not replace or replace; or the cyclic group of a saturated or fractional saturation that does not replace or replace; it is except carbon atom; also contain the heteroatoms formed by oxygen, sulphur and nitrogen-atoms as annular atoms; the aromatic nucleus that does not replace or replace; it also contains the heteroatoms be made up of oxygen, sulphur and nitrogen-atoms as annular atoms except carbon atom.
In the presence of alkali, in inert solvent, be reflected at 0 ℃ to 80 ℃, preferred 20 ℃ to 60 ℃ are carried out routinely with standard method [referring to organic, 17 editions, the 172nd page and thereafter, (1988)].
The organic solvent that is fit to is aliphatic hydrocrbon such as pentane, hexane, hexanaphthene and sherwood oil, aromatic hydrocarbons such as toluene, neighbour, and p-Xylol, halohydrocarbon such as methyl chloride, chloroform and chlorobenzene, ethers such as ether, diisopropyl ether, t-butyl methyl ether, diox, methyl-phenoxide and tetrahydrofuran (THF), nitrile such as acetonitrile and propionitrile, ketone such as acetone, methylethylketone, diethyl ketone and tertiary butyl methyl ketone, and dimethyl sulfoxide (DMSO) and dimethyl formamide, preferred especially methyl chloride, toluene, acetone, acetonitrile and dimethyl formamide.Also can use the mixture of the solvent of being mentioned.
The alkali that is fit to generally is mineral compound such as alkali metal hydroxide and alkaline earth metal hydroxides such as lithium hydroxide, sodium hydroxide, potassium hydroxide and calcium hydroxide, alkalimetal oxide and alkaline earth metal oxide such as Lithium Oxide 98min, sodium oxide, calcium oxide and magnesium oxide, silver suboxide, alkalimetal hydride and alkaline earth metal hydride such as lithium hydride, sodium hydride, potassium hydride KH and hydrolith, alkali metal ammonia compound such as lithamide, ammonification sodium and ammonification potassium, alkaline carbonate and alkaline earth metal carbonate such as Quilonum Retard and lime carbonate, and alkali metal hydrocarbonate such as sodium bicarbonate, organometallic compound, particularly alkali alkyl such as lithium methide, butyllithium and phenyl lithium, magnesium alkyl halide such as methylmagnesium-chloride and alkali metal alcoholate or alkaline-earth metal alcoholate such as sodium methylate, sodium ethylate, potassium ethylate, potassium tert.-butoxide and diformazan magnesium alkoxide, also has organic bases in addition, for example, tertiary amine such as Trimethylamine 99, triethylamine, triisopropyl ethylamine and N-methyl piperidine, pyridine, the pyridine such as the collidine that replace, lutidine and 4-dimethylaminopyridine, and dicyclo amine.Particularly preferred material is sodium hydroxide, salt of wormwood and potassium tert.-butoxide.Alkali is usually with equimolar amount, excessive or use as solvent if desired.
The potassiumiodide of crown ether of adding catalytic amount (as 18-hat-6,15-hat-5) or 0.01 to 10% weight ratio can help the carrying out that reacts as catalyzer.
Reaction also can be carried out in the two-phase system of being made up of the aqueous solution of alkali metal hydroxide, alkaline carbonate, alkaline earth metal hydroxides and alkaline earth metal carbonate and organic phase such as virtue and/or halohydrocarbon.The phase-transfer catalyst that is fit to is, for example, and ammonium halide and Tetrafluoroboric acid ammonium salt and halogenation such as 4-butyl phosphonium chloride and 4-phenyl phosphonium bromide.
At first by H-Y *-R 1Obtain corresponding negatively charged ion with alkali reaction, with the phenyl derivatives reaction, can help the carrying out that reacts again.B.2 R 4=the alkenyl that do not replace or replace
Benzyl halide is I.2 after the phosphorylation, subsequently by phosphorons acid compound I.5 with aldehydes through Wittig or Wittig-Horner reaction, make corresponding vinylidene derivative I .6.
Figure A9619470100141
Figure A9619470100151
Φ is acyl group, particularly phenyl in formula IXa; R in formula IXb XBe alkyl or acyl group, particularly C 1-C 4-alkyl or phenyl.
At formula X with I.5, R 1Be alkyl, alkenyl or the alkynyl that does not replace or replace, the cyclic group of the saturated or fractional saturation that does not replace or replace, it is except carbon atom, also contain the heteroatoms formed by oxygen, sulphur and nitrogen-atoms as annular atoms, the aromatic nucleus that does not replace or replace, it also contains the heteroatoms be made up of oxygen, sulphur and nitrogen-atoms as annular atoms except carbon atom.
In a manner known way, with halogenide I.2 with phosphide IXa or phosphite IXb reaction [referring to Houben-Weyl, the 4th edition, the XII/I volume, the 79th page and thereafter and the 433rd page and (1963) thereafter].
I.2, educt normally reacts to each other with equimolar amount with IXa or IXb.I.2 to be benchmark, adopt excessive IXa or IXb, perhaps can be favourable for yield.
In the presence of alkali, in inert solvent, at-30 ℃ to 60 ℃, preferred 0 ℃ to 40 ℃, I.5 the phosphorus derivant that obtains carries out Wittig or Wittig-Horner reaction with formula X aldehyde subsequently.
The organic solvent that is fit to is aliphatic hydrocrbon such as pentane, hexane, hexanaphthene and sherwood oil, aromatic hydrocarbons such as toluene, adjacent, between and p-Xylol, halohydrocarbon such as methyl chloride, chloroform and chlorobenzene, ethers such as ether, diisopropyl ether, t-butyl methyl ether diox, methyl-phenoxide and tetrahydrofuran (THF), nitrile such as acetonitrile and propionitrile, ketone such as acetone, methylethylketone, diethyl ketone and tertiary butyl methyl ketone, alcohols such as methyl alcohol, ethanol, n-propyl alcohol, Virahol, the propyl carbinol and the trimethyl carbinol and dimethyl sulfoxide (DMSO) and dimethyl formamide, preferred especially ether, tetrahydrofuran (THF), dimethyl sulfoxide (DMSO) and dimethyl formamide.Also can use the mixture of the solvent of being mentioned.
The alkali that is fit to generally is mineral compound such as alkali metal hydroxide and alkaline earth metal hydroxides such as lithium hydroxide, sodium hydroxide, potassium hydroxide and calcium hydroxide, basic metal and alkaline earth metal oxide such as Lithium Oxide 98min, sodium oxide, calcium oxide and sodium hydride, potassium hydride KH and hydrolith, alkali metal ammonia compound such as lithamide, ammonification sodium and ammonification potassium, alkaline carbonate and alkaline earth metal carbonate such as Quilonum Retard and lime carbonate, and alkali metal hydrocarbonate such as sodium bicarbonate, organometallic compound, particularly alkali alkyl such as lithium methide, butyllithium and phenyl lithium, magnesium alkyl halide such as methylmagnesium-chloride and alkali metal alcoholate or alkaline-earth metal alcoholate such as sodium methylate, sodium ethylate, potassium ethylate, potassium tert.-butoxide and diformazan magnesium alkoxide, also has organic bases in addition, for example, tertiary amine such as Trimethylamine 99, triethylamine, diisopropyl ethyl amine and N-methyl piperidine, pyridine, the pyridine such as the collidine that replace, lutidine and 4-dimethylaminopyridine, and dicyclo amine.Used particularly preferred material is sodium methylate, tert-butyl potassium, sodium hydride, salt of wormwood and n-Butyl Lithium.Alkali is to use equimolar amount, but that they also can adopt is excessive, can be used as solvent if desired.
I.5, educt generally reacts to each other with equimolar amount with X.To be benchmark I.5, adopt excessive X, for yield, perhaps can be favourable.
In above-mentioned improvement reaction, I.7 I.2 the acquisition of Compound I .6 also can obtain corresponding phenyl aldehyde by oxidation benzyl halide at first, and similarly I.7 phenyl aldehyde carries out Wittig or Wittig-Horner reaction with phosphorus compound Xa and Xb subsequently.
Figure A9619470100161
The oxygenant [OX] that is fit to is, for example, methylmorpholine N-oxide compound monohydrate (referring to EP-A393 428) or dimethyl sulfoxide (DMSO) [" Chemical Society's magazine " chemical association magazine 1964, p.520; " organic chemistry magazine " organic chemistry magazine 24,1792 (1959)].
Wittig subsequently or Wittig-Horner reaction are carried out under these conditions.B.3 R=is by the organic radical of oxygen, sulfydryl or amino bonded
L in formula XI 1Be replaceable leavings group of a nucleophilic such as halogen (for example chlorine, bromine and iodine) or alkyl or acyl group sulfonate radical (for example methylsulphonic acid root, trifluoromethane sulfonic acid root, Phenylsulfonic acid root and 4-aminomethyl phenyl sulfonate radical).
Figure A9619470100171
In inertia solution, in the presence of the alkali and in the transition-metal catalyst existence or not, reaction is generally carried out [referring to " Russia is chemical " [Russ.Chem.Rev.] 43,679 (1974) according to the principle of Ullmann reaction; " organic chemistry magazine " 29,977 (1964)], or the principle of nucleophilic substitution reaction is carried out [referring to " chemical association magazine " 1942,381; " heterocyclic chemistry magazine " 15,1513 (1978)].
The organic solvent that is fit to is aliphatic hydrocrbon such as pentane, hexane, hexanaphthene and sherwood oil, aromatic hydrocarbons such as toluene, neighbour, and p-Xylol, halohydrocarbon such as methyl chloride, chloroform and chlorobenzene, ethers such as ether, diisopropyl ether, t-butyl methyl ether, diox, methyl-phenoxide and tetrahydrofuran (THF), nitrile such as acetonitrile and propionitrile, ketone such as acetone, methylethylketone, diethyl ketone and tertiary butyl methyl ketone, alcohols such as methyl alcohol, ethanol, n-propyl alcohol, Virahol, propyl carbinol and the trimethyl carbinol and dimethyl sulfoxide (DMSO) and dimethyl formamide, preferred especially acetone and dimethyl formamide.Also can use the mixture of the solvent of being mentioned.
Starting raw material normally reacts to each other with equimolar amount.I.8 to be benchmark, adopt L excessive or in shortage 1-A 1, perhaps can be favourable for yield.B.4?R 4＝-CR a＝N-WR a-A 2
R wherein 4Be-CR a=N-WR a-A 2The Compound I of group for example can be obtained by corresponding ketone, and promptly according to EP-A 499 823 disclosed methods, according to following reaction formula, azanol that I.10 replaces with O-by corresponding ketone or hydroxyl ammonium salt or hydrazine or cake reactant salt obtain.
Figure A9619470100181
In formula I.10 and the radicals R I.11 a, W aAnd A 2Following meanings is arranged: R aBe hydrogen, alkyl, haloalkyl or the aryl that do not replace or replace; W aBe oxygen, amino or alkylamino; A 2The alkyl, alkenyl or the alkynyl that are hydrogen, do not replace or replace, or one do not replace or replace full
With or the cyclic group of fractional saturation, it also contains by oxygen, sulphur and nitrogen-atoms group except carbon atom
The heteroatoms that becomes is as annular atoms;
The aromatic nucleus that does not replace or replace, it also contains by oxygen, sulphur and nitrogen-atoms except carbon atom
The heteroatoms of forming is as annular atoms.
Under general or particular case, reaction conditions is according to the corresponding condition of citing document.
Ketone is (R I.10 a≠ H) acquisition is I.7 by being oxidized to carboxylic acid [referring to organic, the 15th edition, 447 (1977)] by aldehydes, carboxylic acid reaction obtains corresponding halogenation carboxylic acid [referring to organic, the 15th edition, 526 (1977)], with after product and organo-tin compound reaction [" organic reaction " (8), 28 (1954)].B.5?R 4＝-CHR c-O-N＝CR b-A 3
R wherein 4Be-CH R c-O-N=C R b-A 3The Compound I of group, for example can obtain by benzyl halide, promptly according to EP-A 354 571, EP-A 370 629, EP-A 414 153, EP-A 426460, EP-A 460 575, EP-A 472 300, EP-A 585 751, WO-A 90/07,493, WO-A 92/13,830, WO-A 92/18,478, WO-A 92/18,494, WO-A 93/16,986, JP-A 05/201,946 disclosed method, according to following reaction formula, I.2 obtain with hydroxyl imide XII reaction by benzyl halide.
Figure A9619470100191
Formula I.2, XII and I.12 in radicals R b, R cAnd A 3Following meanings is arranged: R bBe hydrogen, cyano group, nitro, halogen, alkyl, haloalkyl, cycloalkyl, alkoxyl group, haloalkane
Oxygen base or the aryl that does not replace or replace; R cBe hydrogen, alkyl or cycloalkyl; A 3Be alkyl, alkenyl or the alkynyl that does not replace or replace, or the saturated or portion that does not replace or replace
Divide saturated cyclic group, it except carbon atom, also contain by oxygen, sulphur and nitrogen-atoms form assorted former
Son is as annular atoms;
The aromatic nucleus that does not replace or replace, it also contains by oxygen, sulphur and nitrogen-atoms except carbon atom
The heteroatoms of forming is as annular atoms.
Under general or particular case, reaction conditions is according to the corresponding condition of citing document.B.6?R 4＝-CHR f-ON＝CR e-CR d＝NO-A 4
R wherein 4Be-CHR f-ON=CR e-CR d=NO-A 4I.2, the Compound I of group for example can be obtained by benzyl halide, promptly according to German patent application p 44 21 180.5, p 44 21 181.3 and 44 21 182.1 disclosed methods, according to following reaction formula, I.2 obtains with the dioxime reaction by benzyl halide.
Figure A9619470100201
Formula I.2, XIV and I.13 in radicals R f, R e, R dAnd A 4Following meanings is arranged: R dAnd R eBe hydrogen, cyano group, nitro, halogen, alkyl, haloalkyl, cycloalkyl, alkoxyl group,
Halogenated alkoxy or the aryl that does not replace or replace; R fBe hydrogen, alkyl or cycloalkyl; A 4Be alkyl, alkenyl or the alkynyl that does not replace or replace, or a saturated or portion that does not replace or replace
Divide saturated cyclic group, it except carbon atom, also contain by oxygen, sulphur and nitrogen-atoms form assorted former
Son is as annular atoms;
The aromatic nucleus that does not replace or replace, it also contains by oxygen, sulphur and nitrogen-atoms group except carbon atom
The heteroatoms that becomes is as annular atoms.
With known mode itself, in inert solvent, exist in base under (as sodium hydride, sodium hydroxide, salt of wormwood and triethylamine) and react according to described method, its method is described in Houben-Weyl, the E14b volume, the 370th page reaches thereafter and Houben-Weyl, the 10/1st volume, and the 1189th page reaches thereafter.
Required dioxime XIV obtains according to following reaction formula:
L among the formula XVI 2Be the replaceable leavings group of a nucleophilic such as halogen or sulfonate radical, preferred chlorine, bromine, iodine, methylsulphonic acid root, trifluoromethane sulfonic acid root, Phenylsulfonic acid root and 4-aminomethyl phenyl sulfonate radical.
With known mode itself, in inert solvent, exist in base under (as salt of wormwood, potassium hydroxide, sodium hydride, pyridine and triethylamine), react according to described method, its method is described in Houben-Weyl, the E14b volume, the 307th page and thereafter, the 370th page and thereafter, the 385th page and thereafter, Houben-Weyl, the 10/4th volume, the 55th page and thereafter, the 180th page and thereafter, the 217th page and thereafter and Houben-Weyl, the E5 volume, the 780th page reaches thereafter.
Similarly, dioxime XIV obtains according to following reaction formula by azanol or its salt (XVIII) that corresponding ketoxime XVII and O-replace.
Figure A9619470100212
The Q of formula XVIII is an acidic anionic, particularly mineral acid (for example halogenide such as muriate or bromide).
With known mode itself, in inert solvent, react according to described method, its method is described in Houben-Weyl, the 10/4th volume, the 73rd page and thereafter or Houben-Weyl. E14b volume, the 369th page and thereafter with the 385th page and thereafter.
In addition, I.14 I.2 the preparation of Compound I .13 at first benzyl halide obtain corresponding benzyl oxime with dioxime XV reaction, and transforming Compound I .14 with compounds X VI subsequently is Compound I .13.
Figure A9619470100221
With known mode itself, in inert solvent, exist in base under (as salt of wormwood, potassium hydroxide, sodium hydride, pyridine and triethylamine), react according to described method, its method is described in Houben-Weyl, the 10/1st volume, the 1189th page and thereafter, Houben-Weyl, the E14b volume, the 307th page and thereafter, the 370th page and thereafter, the 385th page and thereafter, Houben-Weyl, the 10/4th volume, the 55th page and thereafter, the 180th page and thereafter, the 214th page and thereafter and Houben-Weyl, the E5 volume, the 780th page reaches thereafter.
Further the possibility of preparation Compound I .13 is at first the benzyl halide of formula 1.2 is reacted with N-hydroxyl phthalamide, by hydrazinolysis the product that obtains is converted into corresponding benzyl hydroxylamine (I.15), Compound I .13 and formula XVIIa ketoxime reaction subsequently makes Compound I .13.
Figure A9619470100231
With known mode itself, in inert organic solvents,, I.15 I.2 benzyl halide be reacted into benzyl hydroxylamine according to EP-A 463 488 and EP-A585 751 disclosed methods.
In inert solvent (as dimethyl formamide, acetonitrile, tetrahydrofuran (THF) or toluene), in the presence of alkali (as salt of wormwood, sodium hydride, diethylamide, triethylamine or pyridine), transition-metal catalyst [TM] for example palladium-or nickel compound such as diacetylene palladium, palladium chloride, tetrakis triphenylphosphine palladium or Nickel Chloride in the presence of, R wherein 4The Compound I that is the alkynyl that do not replace or replace is by Compound I .15 (R=halogen, particularly bromine and iodine), according to the principle of Heck reaction [referring to " organometallic chemistry magazine " 93,259 (1975)], obtains with the acetylene-derivative reaction.
Figure A9619470100241
R tThe cyclic group of the alkyl that is hydrogen, does not replace or replace, the saturated or fractional saturation that do not replace or replace,
It also contains the heteroatoms be made up of oxygen, sulphur and nitrogen-atoms as annular atoms except carbon atom,
The aromatic nucleus that does not replace or replace, it also contains by oxygen, sulphur and nitrogen-atoms group except carbon atom
The heteroatoms that becomes is as annular atoms;
Particularly preferred compound is the alkyl phenyl acetic ester R wherein of formula I 4Be A 1-Y 1-group, A 1And Y 1Following meanings is arranged: Y 1Be a direct key, oxygen, sulphur, amino or alkylamino; A 1Be alkyl, alkenyl or the alkynyl that does not replace or replace, or the saturated or part that does not replace or replace
Saturated cyclic group, it also contains the heteroatoms of being made up of oxygen, sulphur and nitrogen-atoms except carbon atom
As annular atoms;
The aromatic nucleus that does not replace or replace, it also contains by oxygen, sulphur and nitrogen-atoms except carbon atom
The heteroatoms of forming is as annular atoms;
The alkyl phenyl acetic ester of other preferred formula I is such compound, wherein R 4Be CH 2OA 1, A wherein 1The cyclic group of the saturated or fractional saturation that does not particularly replace or replace, it also contains the heteroatoms be made up of oxygen, sulphur and nitrogen-atoms as annular atoms except carbon atom; Or the aromatic nucleus that does not replace or replace, it also contains the heteroatoms be made up of oxygen, sulphur and nitrogen-atoms as annular atoms except carbon atom.
In the same manner, preferred formula I alkyl phenyl acetic ester is such compound, wherein R 4Be A 2-W aN=CR a-group, wherein A 2, W aAnd R aFollowing meanings is arranged: R aBe hydrogen, alkyl, haloalkyl or the aryl that do not replace or replace; W aBe oxygen, amino or alkylamino; A 2The alkyl, alkenyl or the alkynyl that are hydrogen, do not replace or replace, or do not replace or replace saturated or
The cyclic group of fractional saturation, it also contains by mixing that oxygen, sulphur and nitrogen-atoms are formed except carbon atom
Atom is as annular atoms; Or
The aromatic nucleus that does not replace or replace, it also contains by oxygen, sulphur and nitrogen-atoms group except carbon atom
The heteroatoms that becomes is as annular atoms.
In addition, preferred formula I alkyl phenyl acetic ester is such compound, and wherein R is A 3-CR b=NOCHR c-group, wherein R b, R cAnd A 3Following meanings is arranged: R bBe hydrogen, cyano group, nitro, halogen, alkyl, haloalkyl, cycloalkyl, alkoxyl group, haloalkane
Oxygen base or the aryl that does not replace or replace; R cBe hydrogen, alkyl or cycloalkyl; A 3Be alkyl, alkenyl or the alkynyl that does not replace or replace, or the saturated or part that does not replace or replace
Saturated cyclic group, it also contains the heteroatoms of being made up of oxygen, sulphur and nitrogen-atoms except carbon atom
As annular atoms;
The aromatic nucleus that does not replace or replace, it also contains by oxygen, sulphur and nitrogen-atoms group except carbon atom
The heteroatoms that becomes is as annular atoms.
Also having preferred formula I alkyl phenyl acetic ester is some wherein R 4Be A 4-ON=CR d-CR e=NO-CHR f-group, wherein A 4, R d, R eAnd R fFollowing meanings is arranged: R dAnd R eBe hydrogen, cyano group, nitro, halogen, alkyl, haloalkyl, cycloalkyl, alkoxyl group, halogenated alkoxy or the aryl that do not replace or replace; R fBe hydrogen, alkyl or cycloalkyl; A 4Be alkyl, alkenyl or the alkynyl that does not replace or replace, or the cyclic group of the saturated or fractional saturation that does not replace or replace, it also contains the heteroatoms be made up of oxygen, sulphur and nitrogen-atoms as annular atoms except carbon atom; The aromatic nucleus that does not replace or replace, it also contains the heteroatoms be made up of oxygen, sulphur and nitrogen-atoms as annular atoms except carbon atom.
Other particularly preferred formula I alkyl phenyl acetic ester is such compound, wherein R 4And R 3One of group forms with the phenyl ring of their institute's bondings and is selected from one group of following dicyclo that does not replace or replace: draw together cumarone, thionaphthene, indoles, isoindole and naphthalene.
In above-mentioned structural formula in the definition of the symbol of indication, collective noun used, the following group of its general proxy: halogen: fluorine, chlorine, bromine and iodine; Alkyl: have saturated straight chain or the branched alkyl of 1 to 10 carbon atom, for example C1-C 6-alkyl such as methyl, ethyl, propyl group, the 1-Methylethyl, butyl, the 1-methyl-propyl, the 2-methyl-propyl, 1, the 1-dimethyl ethyl, amyl group, the 1-methyl butyl, the 2-methyl butyl, the 3-methyl butyl, 2, the 2-dimethyl propyl, 1-ethyl propyl group, hexyl, 1, the 1-dimethyl propyl, 1, the 2-dimethyl propyl, the 1-methyl amyl, the 2-methyl amyl, the 3-methyl amyl, the 4-methyl amyl, 1, the 1-dimethylbutyl, 1, the 2-dimethylbutyl, 1, the 3-dimethylbutyl, 2, the 2-dimethylbutyl, 2, the 3-dimethylbutyl, 3, the 3-dimethylbutyl, 1-ethyl butyl, 2-ethyl butyl, 1, 1, 2-trimethyl propyl group, 1, 2, 2-trimethyl propyl group, 1-ethyl-1-methyl-propyl and 1-Ethyl-2-Methyl propyl group, haloalkyl: (as above) has the straight or branched alkyl of 1 to 10 carbon atom, and the hydrogen atom of these groups can partly or entirely be replaced by halogen atom as above, for example C1-C 2-haloalkyl such as chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, methyl fluoride, difluoromethyl, trifluoromethyl, chlorine methyl fluoride, dichlorofluoromethyl, chlorine difluoromethyl, 1-chloroethyl, 1-bromoethyl, 1-fluoro ethyl, 2-fluoro ethyl, 2,2-two fluoro ethyls, 2,2,2-trifluoroethyl, 2-chloro-2-fluoro ethyl, 2-chloro-2,2-two fluoro ethyls, 2,2-two chloro-2-fluoro ethyls, 2,2,2-three chloroethyls and pentafluoroethyl group; Alkoxyl: (as above) has the straight or branched alkyl of 1 to 10 carbon atom, and it (O-) is bonded to main structure via oxygen atom; Halogenated alkoxy: (as above) has the straight or branched haloalkyl of 1 to 10 carbon atom, and it (O-) is bonded to main structure through oxygen atom; Alkylthio group: (as above) has the straight or branched alkyl of 1 to 10 carbon atom, and it (S-) is bonded to main structure through sulphur atom; Alkylamino: (as above) has the straight or branched alkyl of 1 to 10 carbon atom, and it (NH-) is bonded to main structure through nitrogen-atoms; Alkenyl: have 2 to 10 carbon atoms and the unsaturation straight or branched alkenyl of a pair of key is arranged in any desired location, for example, C2-C 6-alkenyl such as vinyl, the 1-acrylic, the 2-acrylic, the 1-methyl ethylene, the 1-cyclobutenyl, the 2-cyclobutenyl, the 3-cyclobutenyl, 1-methyl-1-propylene base, 2-methyl-1-propylene base, 1-methyl-2-acrylic, 2-methyl-2-acrylic, the 1-pentenyl, the 2-pentenyl, the 3-pentenyl, the 4-pentenyl, 1-methyl isophthalic acid-cyclobutenyl, the 2-methyl-1-butene thiazolinyl, the 3-methyl-1-butene base, 1-methyl-2-butene base, 2-methyl-2-butene base, 3-methyl-2-butene base, 1-methyl-3-cyclobutenyl, 2-methyl-3-cyclobutenyl, 3-methyl-3-cyclobutenyl [sic], 1,1-dimethyl-2-acrylic, 1,2-dimethyl-1-acrylic, 1,2-dimethyl-2-acrylic, 1-ethyl-1-acrylic [sic], 1-ethyl-2-acrylic, the 1-vinyl, the 2-vinyl, the 3-vinyl, the 4-vinyl, the 5-vinyl, 1-methyl-1-pentene thiazolinyl [sic], 2-methyl-1-pentene thiazolinyl, 3-methyl-1-pentene thiazolinyl, 4-methylpent-1-thiazolinyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-methyl-2-pentenyl, 4-methyl-2-pentenyl, the 1-methyl-3-pentenyl, 2-methyl-3-pentenyl [sic], the 3-methyl-3-pentenyl, the 4-methyl-3-pentenyl, 1-methyl-4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2-cyclobutenyl, 1,1-dimethyl-3-cyclobutenyl, 1,2-dimethyl-1-cyclobutenyl, 1,2-dimethyl-2-cyclobutenyl, 1,2-dimethyl-3-cyclobutenyl, 1,3-dimethyl-1-cyclobutenyl, 1,3-dimethyl-2-cyclobutenyl, 1,3-dimethyl-3-cyclobutenyl, 2,2-dimethyl-3-cyclobutenyl, 2,3-dimethyl-1-cyclobutenyl, 2,3-dimethyl-2-cyclobutenyl, 2,3-dimethyl-3-cyclobutenyl, 3,3-dimethyl-1-cyclobutenyl, 3,3-dimethyl-2-cyclobutenyl, 1-ethyl-1-cyclobutenyl, 1-ethyl-2-cyclobutenyl, 1-ethyl-3-cyclobutenyl, 2-ethyl-1-cyclobutenyl, 2-ethyl-2-cyclobutenyl, 2-ethyl-3-cyclobutenyl, 1,1,2-trimethyl-2-acrylic, 1-ethyl-1-methyl-2-acrylic, 1-Ethyl-2-Methyl-1-acrylic [sic] or 1-Ethyl-2-Methyl-2-acrylic, alkynyl: have 2 to 10 carbon atoms and the straight or branched alkynyl of one three keys is arranged in any desired location, for example C2-C 6-alkynyl such as acetenyl, the 1-propinyl, 2-propynyl, the 1-butynyl, the 2-butynyl, the 3-butynyl, 1-methyl-2-propynyl, 1-pentyne base, the valerylene base, 3-pentyne base, 4-pentyne base, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 3-methyl-1-butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl-2 propinyl, 1-is alkynyl, 2-is alkynyl, 3-is alkynyl, 4-is alkynyl, 5-is alkynyl, 1-methyl-valerylene base, 1-methyl-3-pentyne base, 1-methyl-4-pentyne base, 2-methyl-3-pentyne base, 2-methyl-4-pentyne base, 3-methyl-1-pentene alkynyl, 3-methyl-4-pentyne base, 4-methyl-1-pentene alkynyl, 4-methyl-valerylene base, 1,1-dimethyl-2-butynyl, 1,1-dimethyl-3-butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-dimethyl-1-butynyl, 1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 2-ethyl-3-butynyl and 1-ethyl-1-methyl-2-propynyl, cycloalkyl: have the monocycle alkyl of 3 to 12 carbon atoms, for example, C3-C 8-cycloalkyl such as cyclopropyl, cyclobutyl, cyclopenta, cyclohexyl, suberyl and ring octyl group, the cyclic group of saturated or fractional saturation, it also contains by oxygen except carbon atom, the hetero atom that sulphur and nitrogen-atoms form is as annular atoms: above-mentioned have 3 epoxy radicals to twelve carbon atom or 5-or a 6-unit heterocycle, it is except carboatomic ring atom, also contain one to three nitrogen-atoms and/or oxygen or sulphur atom or two oxygen and/or sulphur atom, as the 2-oxolane, the 3-tetrahydrofuran base, the 2-tetrahydro-thienyl, the 3-tetrahydro-thienyl, the 2-pyrrolidinyl, the 3-pyrrolidinyl, the 3-isoxazole alkyl, the 4-isoxazole alkyl, the 5-isoxazole alkyl, the 3-isothiazolyl, the 4-isothiazolyl, the 5-isothiazolyl, the 3-pyrazolidinyl, the 4-pyrazolidinyl, the 5-pyrazolidinyl, 2-oxazole alkyl, 4-oxazole alkyl, 5-oxazole alkyl, the 2-thiazolidinyl, the 4-thiazolidinyl, the 5-thiazolidinyl, the 2-imidazolidinyl, the 4-imidazolidinyl, 1,2,4-Evil diazole alkane-3-base, 1,2,4-oxadiazole alkane-5-base, 1,2,4-thiadiazolidine-3-base, 1,2,4-thiadiazolidine-5-base, 1,2,4-triazolidine-3-base, 1,3,4-oxadiazole alkane-2-base, 1,3,4-thiadiazolidine-2-base, 1,3,4-triazolidine-2-base, DHF-2-base, DHF-3-base, 2,4-dihydrofuran-2-base, 2,4-dihydrofuran-3-base, 2,3-dihydro-thiophene-2-base, 2,3-dihydro-thiophene-3-base, 2,4-dihydro-thiophene-2-base, 2,4-dihydro-thiophene-3-base, 2,3-pyrrolin-2-base, 2,3-pyrrolin-3-base, 2,4-pyrrolin-2-base, 2,4-pyrrolin-3-base, 2,3-isoxazole quinoline base-3-base, 3,4-Yi Evil azoles quinoline base-3-base, 4,5-isoxazole quinoline base-3-base, 2,3-isoxazole quinoline base-4-base, 3,4-isoxazole quinoline base-4-base, 4,5-isoxazole quinoline base-4-base, 2,3-isoxazole quinoline base-5-base, 3,4-isoxazole quinoline base-5-base, 4,5-isoxazole quinoline base-5-base, 2,3-isothiazole quinoline base-3-base, 3,4-isothiazole quinoline base-3-base, 4,5-isothiazole quinoline base-3-base, 2,3-isothiazole quinoline base-4-base, 3,4-isothiazole quinoline base-4-base, 4,5-isothiazole quinoline base-4-base, 2,3-isothiazole quinoline base-5-base, 3,4-isothiazole quinoline base-5-base, 4,5-isothiazole quinoline base-5-base, 2,3-pyrazoline-1-base, 2,3-pyrazoline-2-base, 2,3-pyrazoline-3-base, 2,3-pyrazoline-4-base, 2,3-pyrazoline-5-base, 3,4-pyrazoline-1-base, 3,4-pyrazoline-3-base, 3,4-pyrazoline-4-base, 3,4-pyrazoline-5-base, 4,5-pyrazoline-1-base, 4,5-pyrazoline-3-base, 4,5-pyrazoline-4-base, 4,5-pyrazoline-5-base, 2,3-dihydro-oxazole-2-base, 2,3-dihydro-oxazole-3-base, 2,3-dihydro-oxazole-4-base, 2,3-dihydro-oxazole-5-base, 3,4-dihydro-oxazole-2-base, 3,4-dihydro-oxazole-3-base, 3,4-dihydro-oxazole-4-base, 3,4-dihydro-oxazole-5-base, 3,4-dihydro-oxazole-2-base, 3,4-dihydro-oxazole-3-base, 3,4-dihydro-oxazole-4-base, the 2-piperidyl, the 3-piperidyl, the 4-piperidyl, 1,3-diox-5-base, the 2-THP trtrahydropyranyl, the 4-THP trtrahydropyranyl, the 2-tetrahydro-thienyl, 3-tetrahydro pyridazine base, 4-tetrahydro pyridazine base, the 2-tetrahydro-pyrimidine base, the 4-tetrahydro-pyrimidine base, the 5-tetrahydro-pyrimidine base, 2-tetrahydrochysene pyrazinyl, 1,3,5-tetrahydrotriazine-2-base and 1,2,4-tetrahydrotriazine-3-base, aryl: contain the aromatic ring system of Dan Zhisan core of 6 to 14 carboatomic ring atoms, for example phenyl, naphthyl or anthryl, aromatic ring system, it can contain and be selected from oxygen except carboatomic ring atom, the hetero atom of sulphur and nitrogen: aryl as mentioned above, or single or two core heteroaryls, for example-5-unit heteroaryl, contain one to four nitrogen-atoms or one to three nitrogen-atoms and sulphur atom or oxygen atom: 5-unit ring heteroaryl, it can contain one to four nitrogen-atoms except carbon atom, or one to three nitrogen-atoms and sulphur atom or oxygen atom be as link, for example, and the 2-furyl, the 3-furyl, the 2-thienyl, the 3-thienyl, the 2-pyrrole radicals, the 3-pyrrole radicals, the 3-isoxazolyl, 4-Yi Evil azoles base, the 5-isoxazolyl, the 3-isothiazolyl, the 4-isothiazolyl, the 5-isothiazolyl, the 3-pyrazolyl, the 4-pyrazolyl, the 5-pyrazolyl, the 2-oxazolyl, the 4-oxazolyl, the 5-oxazolyl, the 2-thiazolyl, the 4-thiazolyl, the 5-thiazolyl, the 2-imidazole radicals, the 4-imidazole radicals, 1,2,4-oxadiazole-3-base, 1,2,4-Evil diazole-5-base, 1,2,4-thiadiazoles-3-base, 1,2,4-thiadiazoles-5-base, 1,2,4-triazolyl-3-base, 1,3,4-oxadiazole-2-base, 1,3,4-thiadiazoles-2-base, 1,3,4-triazole-2-base,-benzene is opened the 5-unit heteroaryl that condenses, contain one to three nitrogen-atoms or nitrogen-atoms and oxygen atom or sulphur atom: 5-unit ring heteroaryl, it is except carbon atom, can contain one to four nitrogen-atoms, or one to three nitrogen-atoms and sulphur atom or oxygen atom are as ring element, and wherein two adjacent carbocyclic ring units or nitrogen and adjacent carbocyclic ring unit can be through β-1, the basic bridge joint of 3-diene-Isosorbide-5-Nitrae-two,-through the 5-of nitrogen bonding unit heteroaryl, contain one to four ammonia atom, or through the first heteroaryl of the benzo-fused 5-of nitrogen bonding, contain one to three nitrogen-atoms: 5-unit ring heteroaryl, except carbon atom, it can contain one to four nitrogen-atoms or one to three fluorine atom as ring element, and wherein two adjacent carbocyclic ring units or nitrogen and adjacent carbocyclic ring unit can pass through β-1, the basic bridge joint of 3-diene-Isosorbide-5-Nitrae-two, these rings are bonded to main structure through one of azo-cycle unit,-6 yuan of heteroaryls, contain one to three or one to four nitrogen-atoms: 6-unit ring heteroaryl, it is except carbon atom, can contain one to three or one to four nitrogen-atoms as ring element, for example, 2-pyridine radicals, 3-pyridine radicals, 4-pyridine radicals, 3-pyridazinyl, 4-pyridazinyl, 2-pyrimidine radicals, 4-pyrimidine radicals, 5-pyrimidine radicals, 2-pyrazinyl, 1,3,5-triazine-2-base and 1,2,4-triazine-3-base, alkylidene: comprise 3 to 5 CH2The branchiess chain of the divalence of group, as-CH2-、-CH 2CH 2-、 -CH 2CH 2CH 2-、-CH 2CH 2CH 2CH 2-and-CH2CH 2CH 2CH 2CH 2-; Oxygen base alkylidene: comprise 2 to 4 CH2The branchiess chain of the divalence of group, a key oxygen atom is bonded on main structure, as-OCH2-、-OCH 2CH 2-、-OCH 2CH 2CH 2-and-OCH2CH 2CH 2CH 2-; Oxygen base alkylidene oxygen base: comprise 1 to 3 CH2The branchiess chain of the divalence of group, two keys all are bonded on main structure by oxygen atom, as ,-OCH2O-、-OCH 2CH 2O-and-OCH2CH 2CH 2O-; Alkylene group: comprise 1 to 3 CH2Group and one is at any branchiess chain of binary of wishing the CH=CH group of position, as-CH=CHCH2-、-CH＝CH CH 2CH 2-、 -CH 2CH＝CHCH 2CH 2-and-CH=CHCH2CH 2CH 2-; Oxygen base alkylene group: comprise 0 to 2 CH2Group and one are bonded on main structure by the oxygen atom monovalence at any branchiess chain of binary of wishing the CH=CH group of position, as-OCH=CH-,-OCH=CHCH2-、-OCH 2CH＝CH-、-OCH 2CH＝CHCH 2-、 -OCH＝CHCH 2CH 2-and-OCH2CH 2CH=CH-; Oxygen base alkylene group oxygen base: comprise that 0 to 2 CH2 group and one are bonded on main structure by two of oxygen atoms at any branchiess chain of binary of wishing the CH=CH group of position, as-OCH=CHO-,-OCH=CHCH2O-、-OCH 2CH＝CHCH 2O-and-OCH=CHCH2CH 2O-; Organic group: the alkyl that does not replace and replace, alkenyl, alkynyl, cycloalkyl, heterocyclic radical, aryl or heteroaryl.
Alkyl, the qualifier of alkenyl and alkynyl " not replace or replace " is intended to express partly or entirely halo of these groups, the part or all of hydrogen atom that is these groups can be by identical or different aforesaid halogen atom (preferred fluorine, chlorine or bromine) replaces and/or can have one to three (preferred one) following groups: cyano group, nitro, hydroxyl, amino, formyl radical, carboxyl, aminocarboxyl, alkoxyl group, halogenated alkoxy, alkylthio, halogenated alkylthio, alkylamino, dialkyl amido, alkyl-carbonyl, alkoxy carbonyl, the alkyl-carbonyl oxygen base, alkyl amino-carbonyl, dialkyl amino carbonyl, alkyl-carbonyl-amino, alkoxycarbonyl amino, alkyl-carbonyl-N-alkylamino and alkyl-carbonyl-N-alkylamino, described alkyl preferably contains 1 to 6 carbon atom, particularly 1 to 4 carbon atom; Cycloalkyl, cycloalkyl oxy, cycloalkyl sulfenyl, cycloalkyl amino, cycloalkyl-n-alkylamino, heterocyclic radical, heterocyclyloxy base, heterocyclic radical sulfenyl, heterocyclic radical amino or heterocyclic radical-N-alkylamino, they all are not replace or replaced by conventional group, these member ring systems contain 3 to 12 links, preferred 2 to 8 links, 3 to 6 links particularly, and the alkyl in these groups preferably contains 1 to 6 carbon atom, particularly 1 to 4 carbon atom; Aryl, aryloxy, arylthio, arylamino, aryl-n-alkylamino, alkoxy aryl, alkylthio-aryl, aryl-alkyl amino, arylalkyl-N-alkylamino, heteroaryl, heteroaryloxy, heteroarylthio, heteroaryl amino, heteroaryl-N-alkylamino, the heteroaryl alkoxyl group, the heteroaryl alkylthio, heteroarylalkyl amino, heteroarylalkyl-N-alkylamino, they all are not replace or replaced by conventional group, aryl preferably contains 6 to 10 links, 6 links (phenyl) particularly, heteroaryl particularly contains 5 or 6 links and the alkyl in these groups preferably contains 1 to 6 carbon atom, particularly 1 to 4 carbon atom.
Encircle (saturated, unsaturation or aromatics) qualifier " replace or replace " of group is intended to express partly or entirely halo of these groups, promptly, the hydrogen atom of these groups can be partly or entirely by identical or different aforesaid halogen atom (preferred fluorine, chlorine or bromine, fluorine or chlorine particularly) replaces, and/or can be with one to four (preferred one to three) following groups: cyano group, nitro, hydroxyl, amino, carboxyl, aminocarboxyl, alkyl, haloalkyl, alkenyl, halogenated alkenyl, alkenyl oxy, halogenated alkenyl oxy, alkynyl, the halo alkynyl, alkynyloxy group, the halo alkynyloxy group, alkoxyl group, halogenated alkoxy, alkylthio, halogenated alkylthio, alkylamino, dialkyl amido, alkyl-carbonyl, alkoxy carbonyl, the alkyl-carbonyl oxygen base, alkyl amino-carbonyl, dialkyl amino carbonyl, alkyl-carbonyl-amino, alkoxycarbonyl amino, alkyl-carbonyl-N-alkylamino and alkyl-carbonyl-N-alkylamino, alkyl in these groups preferably contains 1 to 6 carbon atom, 1 to 4 carbon atom particularly, and described alkenyl in these groups or alkynyl contain 2 to 8, preferred 2 to 6,2 to 4 carbon atoms particularly; And/or one to three (particularly one) following groups: cycloalkyl, cycloalkyl oxy, cycloalkyl sulfenyl, cycloalkyl amino, cycloalkyl-N-alkylamino, heterocyclic radical, heterocyclyloxy base, heterocyclic radical sulfenyl, heterocyclic radical amino or heterocyclic radical-N-alkylamino, they all are not replace or replaced by conventional group, these member ring systems contain 3 to 12 links, preferred 2 to 8 links, 3 to 6 links particularly, and the alkyl in these groups preferably contains 1 to 6 carbon atom, particularly 1 to 4 carbon atom; Aryl, aryloxy, arylthio, arylamino, aryl-n-alkylamino, alkoxy aryl, alkylthio-aryl, aryl-alkyl amino, arylalkyl-N-alkylamino, heteroaryl, heteroaryloxy, heteroarylthio, heteroaryl amino, heteroaryl-N-alkylamino, the heteroaryl alkoxyl group, the heteroaryl alkylthio, heteroarylalkyl amino, heteroarylalkyl-N-alkylamino, they all are not replace or replaced by conventional group, aryl preferably contains 6 to 10 links, 6 links (phenyl) particularly, heteroaryl particularly contains 5 or 6 links and the alkyl in these groups preferably contains 1 to 6 carbon atom, particularly 1 to 4 carbon atom; And/or one or two (particularly one) following groups: formyl radical and CR Iii=NOR Iv, R IiiBe hydrogen or alkyl, and R IvBe alkyl or aralkyl, described alkyl preferably contains 1 to 6 carbon atom, 1 to 4 carbon atom particularly, and aryl is phenyl particularly, and this phenyl is not substituted or can be replaced by conventional group, or two adjacent C atoms can have C in its member ring systems 3-C 5-alkylidene group, C 3-C 5-alkylene group, oxygen base-C 2-C 4-alkylidene group, oxygen base-C 1-C 3-alkylidene group oxygen base, oxygen base-C 2-C 4-alkylene group, oxygen base-C 2-C 4-alkylene group oxygen base or β-diene two bases, these bridges itself are halo and/or be with to three, particularly one or two following groups: C partly or entirely 1-C 4-alkyl, C 1-C 4-haloalkyl, C 1-C 4-alkoxyl group, C 1-C 4-halogenated alkoxy and C 1-C 4-alkylthio.
Conventional group should be interpreted as following substituting group especially: halogen, cyano group, nitro, C 1-C 4-alkyl, C 1-C 4-haloalkyl, C 1-C 4-alkoxyl group, C 1-C 4-halogenated alkoxy, C 1-C 4-alkylamino, two-C 1-C 4-alkylamino and C 1-C 4-alkylthio.For biological action, preferred especially following formula I .A compound:
Figure A9619470100351
Substituting group wherein has following connotation W aBe oxygen methylene, methylene radical oxygen base, ethylidene or vinylidene; A aBe aryl or heteroaryl, any can be replaced by conventional group and/or can be with one or two (particularly one) following groups: formyl radical or CR Iii=NOR Iv
Preferred especially such formula I.A compound, wherein W aIt is methylene radical oxygen base.
In addition, other preferred formula I.A compound, wherein W aIt is the oxygen methylene.
Preferred equally especially such formula I.A compound, wherein W aIt is vinylidene.
Other particularly preferred formula I.A compound is, wherein W aIt is ethylidene.
Particularly, other preferred such formula I.A compound, wherein A aIt is the aryl that does not replace and replace.
Particularly, other same preferred such formula I.A compound, wherein A aBe 6 yuan of hetero-aromatic rings that do not replace and replace.
Particularly, also preferred such formula I.A compound, wherein A aBe 5 yuan of hetero-aromatic rings that do not replace and replace.
Particularly, other preferred such formula I.A compound, wherein A aBe the aryl that does not replace and replace, have CR Iii=NOR IvGroup.
Particularly, further preferred such formula I.A compound, wherein A aBe the phenyl that does not replace and replace, have CR Iii=O group.
Particularly, other preferred such formula I.A compound, wherein A aBe the phenyl that does not replace and replace, have CR Iii=NOR IvGroup.
Particularly, also same preferred such formula I.A compound, wherein A aBe pyridyl and the pyrimidyl that does not replace and replace.
Preferred other formula I.B compound: Substituting group wherein has following connotation W bBe a direct key, oxygen, sulphur, amino or alkylamino, and A bBe aryl or heteroaryl, any can be replaced by conventional group and/or can be with one or two (particularly one) following groups: formyl radical, CR Iii=NOR IvOr (preferred benzene) aryl or heteroaryl (preferred pyridyl, pyrimidyl or triazinyl) of not replacing and replacing by conventional group
Particularly, preferred such formula I.B compound, wherein W bBe oxygen.
Particularly, same preferred such formula I.B compound, wherein W bIt is a direct key.
Particularly, other preferred such formula I.B compound, wherein W bBe sulphur.
Particularly, preferred such formula I.B compound, wherein W bIt is the aryl that does not replace and replace.
Particularly, other preferred such formula I.B compound, wherein W bBe 6 yuan of hetero-aromatic rings that do not replace and replace.
Particularly, also same preferred such formula I.B compound, wherein A bBe aryl that does not replace and replace or the heteroaryl that is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl or 1,3,5-triazines base.
Particularly, other further preferred such formula I.B compound, wherein A bIt is the pyrimidyl that has the pyridyl oxygen base group that does not replace and replace that does not replace and replace.
Particularly, further same preferred such formula I.B compound, wherein A bBe the 1,3,5-triazines base that does not replace and replace, wherein the phenoxy group that does not replace and replace arranged at the 4-bit strip.
Preferred other formula I.C compound:
Figure A9619470100371
Substituting group wherein has following connotation R 1And R 2Be C 1-C 4-alkyl, W cBe CR γ R δ-C (=O)-T c- * is a singly-bound or two key, and wherein under the singly-bound situation, this C atom can have a hydrogen atom, R in any situation γBe hydrogen or alkyl, R δBe hydrogen, cyano group, nitro halogen or alkyl, T is oxygen, sulphur, amino or alkylamino, and c is 0 or 1 ,- *Be one to be connected to A cKey, A cBe alkyl, alkenyl, alkynyl, cycloalkyl or aryl arylalkyl, aromatic yl alkenyl, heteroaryl, heteroarylalkyl or heteroaryl alkenyl, wherein any is not replaced and replaces by conventional group.
Particularly, preferred such formula I.C compound, wherein W cBe CH=C (halogen)-C (=O)-O- *
Particularly, other preferred such formula I.C compound, wherein W cBe CH=C (halogen)-C (=O)-NH-R *
Particularly, same preferred such formula I.C compound, wherein W cBe CH=C (halogen)-C (=O)-NH- *
Particularly, other preferred such formula I.C compound, wherein W cBe CH=C (halogen)-C (=O)-.
Particularly, preferred such formula I.C compound, wherein A cIt is alkyl.
Particularly, other preferred such formula I.C compound, wherein A cIt is alkenyl.
Particularly, same preferred such formula I.C compound, wherein A cIt is alkynyl.
Further preferred formula I.D compound is these A wherein dFollowing connotation: A is arranged dBe the cycloalkyl that can have one to four following groups: cyano group, halogen, alkyl, haloalkyl, alkoxy carbonyl or aryl, arylalkyl or aromatic yl alkenyl, wherein any can not replaced and replace by conventional group.
Particularly, preferred such formula I.D compound, wherein A dIt is the cyclopropyl that does not replace and replace.
The further preferred formula I.E compound of institute is a following formula: compound:
Figure A9619470100401
Its substituting group has following connotation W eBe CR a=N-T a-#, R aBe hydrogen, alkyl, haloalkyl, or the aryl that does not replace and replace by conventional group, T aBe oxygen, amino or alkylamino ,-# is a connection A eKey, A eBe hydrogen,
The alkyl that does not replace and replace, alkyl-carbonyl, alkoxyl group carbonyl carboxyl, alkenyl, alkenyl carbonyl, alkenyl oxy carbonyl, alkynyl, alkynyl carbonyl and alkynyloxy base carbonyl, or
The cycloalkyl that does not replace and replace, heterocyclic radical, aryl, arylalkyl, aromatic yloxy yl alkyl, aromatic yl alkenyl, aryloxy alkenyl, aryl carbonyl, aryloxy carbonyl, heteroaryl, heteroarylalkyl, heteroaryl oxygen base alkenyl, heteroaryl carbonyl and heteroaryl oxygen base carbonyl.
Particularly, preferred such formula I.E compound, wherein W eBe CH (CH 3)=N-O-#.
Particularly, other preferred such formula I.E compound, wherein W eBe CH (CH 3)=N-NH-#.
Particularly, also preferred such formula I.E compound, wherein W eBe CH=N-N (CH 3)-#.
Particularly, preferred such formula I.E compound, wherein A eIt is alkyl.
Particularly, other preferred such formula I.E compound, wherein A eIt is the arylalkyl that does not replace and replace.
Particularly, same preferred such formula I.E compound, wherein A eIt is the heteroarylalkyl that does not replace and replace.
Same preferred such formula I.F compound,
Figure A9619470100411
Substituting group wherein has following connotation: A fBe the phthalimide that does not replace and replace by conventional group, or-N=CR gR hGroup, R gBe hydrogen, halogen, cyano group, nitro
The alkyl that does not replace and replace, alkenyl or alkynyl, the cycloalkyl that does not replace and replace, heterocyclic radical, aryl or heteroaryl, R hThe alkyl that is hydrogen, does not replace and replace, alkoxyl group, alkyl carboxyl, alkoxyl group carboxyl, alkenyl, alkenyl oxy, alkenyl carbonyl, alkenyl oxy carbonyl, alkynyl, alkynyloxy base, alkynyl carbonyl and alkynyloxy base carbonyl,
The cycloalkyl that does not replace and replace, cycloalkyl oxy, heterocyclic radical, the heterocyclyloxy base, aryl, aryloxy, arylalkyl, alkoxy aryl, aromatic yloxy yl alkyl, the aryloxy alkoxyl group, aromatic yl alkenyl, aromatic yl alkenyl oxygen base, the aryloxy alkenyl, the aryloxy alkenyl oxy, aryl carbonyl, aryl carbonyl oxygen base, the aryloxy carbonyl, aryloxy ketonic oxygen base, heteroaryl, heteroaryl oxygen base, heteroarylalkyl, the heteroaryl alkoxyl group, heteroaryl oxygen base alkyl, heteroaryl oxygen base alkyl oxy, the heteroaryl alkenyl, the heteroaryl alkenyl oxy, heteroaryl oxygen base alkenyl, heteroaryl oxygen base alkenyl oxy, the heteroaryl carbonyl, heteroaryl ketonic oxygen base, heteroaryl oxygen base carbonyl and heteroaryl oxygen base ketonic oxygen base, or R gAnd R hWith the C atom of their institute's bondings is the heterocyclic radical of the cycloalkyl, cycloalkenyl or saturated or the fractional saturation that do not replace and replaced by conventional group.
Particularly, preferred such formula I.F compound, wherein R gIt is alkyl.
Particularly, same preferred such formula I.F compound, wherein R gIt is cycloalkyl.
Particularly, preferred such formula I.F compound, wherein R gIt is haloalkyl.
More especially, preferred such formula I.F compound, wherein R gBe cyano group.
Particularly, other preferred such formula I.F compound, wherein R gIt is alkylthio.
Particularly, other preferred such formula I.F compound, wherein R gBe methyl, ethyl, n-propyl, cyclopropyl, trifluoromethyl, cyano group or methylthio group.
Particularly, preferred such formula I.F compound, wherein R hIt is the aryl that does not replace and replace.
Particularly, other preferred such formula I.F compound, wherein R hIt is the heteroaryl that does not replace and replace.
Particularly, also preferred such formula I.F compound, wherein R hIt is alkyl.
Particularly, other preferred such formula I.F compound, wherein R hIt is cycloalkyl.
Further preferred formula I.G compound is a following formula: compound: Its substituting group has following connotation W hBe CHR f-ON=CR e-CR d=NO-#, R dBe hydrogen, cyano group, nitro, halogen, alkyl, haloalkyl, cycloalkyl, alkoxyl group, halogenated alkoxy or the aryl that does not replace and replace by conventional group, R fBe hydrogen, alkyl or cycloalkyl ,-# is a connection A kKey, A hBe hydrogen, C 1-C 10-alkyl, C 3-C 6-cycloalkyl, C 2-C 10-alkenyl, C 3-C 10-alkynyl, C 1-C 10-alkyl-carbonyl, C 2-C 10-alkenyl carbonyl, C 3-C 10-alkynyl carbonyl or C 1-C 10-alkane alkylsulfonyl, these groups be halo and/or carry one to three following groups partly or entirely: cyano group, nitro, hydroxyl, sulfydryl (merkzpto), amino, carboxyl, aminocarboxyl, thiocarbamoyl, halogen, C 1-C 6-alkyl, C 1-C 6-haloalkyl, C 1-C 6-alkyl sulphonyl, C 1-C 6-alkyl sulphinyl, C 3-C 6-cycloalkyl, C 1-C 6-alkoxyl group, C 1-C 6-halogenated alkoxy, C 1-C 6-alkoxy carbonyl, C 1-C 6-alkylthio, C 1-C 6-alkylamino, two-C 1-C 6-alkylamino, C 1-C 6-alkyl amino-carbonyl, two-C 1-C 6-alkyl amino-carbonyl, C 1-C 6-alkylamino sulfenyl carbonyl, two-C 1-C 6-alkylamino sulfenyl carbonyl, C 2-C 6-alkenyl, C 2-C 6-alkenyl oxy, benzyl, benzyl oxygen base, aryl, aryloxy, artyl sulfo, heteroaryl, heteroaryl oxygen base and heteroaryl sulfenyl, these aromatic bases and assorted aromatic base, part or all of halo and/or carry one to three following groups successively: cyano group, nitro, hydroxyl, sulfydryl (merkzpto), amino, carboxyl, aminocarboxyl, halogen, thiocarbamoyl, C 1-C 6-alkyl, C 1-C 6-haloalkyl, C 1-C 6-alkyl sulphonyl, C 1-C 6-alkyl sulphinyl, C 3-C 6-cycloalkyl, C 1-C 6-alkoxyl group, C 1-C 6-halogenated alkoxy, C 1-C 6-alkoxy carbonyl, C 1-C 6-alkylthio, C 1-C 6-alkylamino, two-C 1-C 6-alkylamino, C 1-C 6-alkyl amino-carbonyl, two-C 1-C 6-alkyl amino-carbonyl, C 1-C 6-alkylamino sulfenyl carbonyl, two-C 1-C 6-alkylamino sulfenyl carbonyl, C 2-C 6-alkenyl, C 2-C 6-alkenyl oxy, benzyl, benzyl oxygen base, aryl, aryloxy, artyl sulfo, heteroaryl, heteroaryl oxygen base and heteroaryl sulfenyl or C (=NOR 1)-X o-R 2Aryl, heteroaryl, aryl carbonyl, heteroaryl carbonyl, aryl sulfonyl or heteroarylsulfonyl, these groups be halo and/or carry one to three following groups partly or entirely: cyano group, nitro, hydroxyl, sulfydryl (merkzpto), amino, carboxyl, aminocarboxyl, thiocarbamoyl, halogen, C 1-C 6-alkyl, C 1-C 6-haloalkyl, C 1-C 6-alkyl-carbonyl, C 1-C 6-alkyl sulphonyl, C 1-C 6-alkyl sulphinyl, C 3-C 6-cycloalkyl, C 1-C 6-alkoxyl group, C 1-C 6-halogenated alkoxy, C 1-C 6-alkoxy carbonyl, C 1-C 6-alkylthio, C 1-C 6-alkylamino, two-C 1-C 6-alkylamino, C 1-C 6-alkyl amino-carbonyl, two-C 1-C 6-alkyl amino-carbonyl, C 1-C 6-alkylamino sulfenyl carbonyl, two-C 1-C 6-alkylamino sulfenyl carbonyl, C 2-C 6-alkenyl, C 2-C 6-alkenyl oxy, benzyl, benzyl oxygen base, aryl, aryloxy, heteroaryl, heteroaryl oxygen base or C (=NOR 1)-X o-R 2Wherein T be oxygen, sulphur or nitrogen and wherein nitrogen carry hydrogen or C 1-C 6-alkyl; O is 0 or 1; R 1Be hydrogen or C 1-C 6-alkyl and R 2Be hydrogen or C 1-C 6-alkyl.
Particularly, preferred such formula I.H compound, wherein W hBe CH 2-ON=C (CH 3)-C (alkyl)=N-O-#.
Particularly, other preferred such formula I.H compound, wherein W hBe CH 2-ON=C (CH 3)-C (aryl)=N-O-#.
Particularly, also preferred such formula I.K compound, wherein Y kBe CH 2-ON=C (CH 3)-C (cycloalkyl)=N-O-#.
Particularly, preferred such formula I.H compound, wherein W hBe CH 2-ON=C (CH 3)-C (heteroaryl)=N-O-#.
Particularly, preferred such formula I.H compound, wherein W hBe CH 2-ON=C (CH 3)-C (CH 3)=N-O-#.
Particularly, preferred such formula I.H compound, wherein W hBe CH 2-ON=C (CH 3)-C (C 6H 5)=N-O-#.
Particularly, preferred such formula I.H compound, wherein A hBe hydrogen or C 1-C 6-alkyl.
Particularly, preferred in addition such formula I.H compound, wherein A hBe arylalkyl, heteroarylalkyl, aromatic yloxy yl alkyl or the heteroaryl oxygen base alkyl that does not replace and replace.
Particularly, preferred such formula I.H compound, wherein A hBe aryl or the heteroaryl that does not replace and replace.
Particularly, other preferred such formula I.H compound, wherein A hBe methyl or ethyl.
Particularly, also preferred such formula I.H compound, wherein A hBe arylalkyl or the heteroarylalkyl that does not replace and replace.
Particularly, preferred such Compound I (or I.A to I.H), wherein U is that oxygen and V are oxygen or amino.
Particularly, preferred such Compound I (or I.A to I.H), wherein U is that amino and V are oxygen.
Particularly, preferred such Compound I (or I.A to I.H), wherein U is that amino oxygen base and V are oxygen.
Particularly, preferred such Compound I (or I.A to I.H), wherein R 1Be methyl or ethyl, particularly methyl.
Particularly, preferred such Compound I (or I.A to I.H), wherein R 2Be methyl or ethyl, particularly methyl.
For its biological activity, can adopt the isomer of isomer mixture and purifying, the isomer of purifying may have higher activity than isomer mixture.Consider its purposes, the Compound I that is collected in down in the tabulation is particularly preferred.The substituent group of the conduct of in table, mentioning in addition itself (being independent of the combination that they are mentioned) also as related substituent particularly preferred embodiment.Table 1
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe a direct key, X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 2
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH=CH-that X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 3
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH ≡ CH-, X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 4
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe that (O-), X, Y and Z are=CH-and A oxygen aFor each compound, corresponding to a group in the Table A.Table 5
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 6
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-OCH 2- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 7
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CO-O- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 8
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-O-CO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 9
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CO-NH- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 10
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-NH-CO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 11
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-C (CH 3)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 12
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 13
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 14
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 15
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 16
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe a direct key, X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 17
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH=CH-that X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 18
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-C ≡ C-that X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 19
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe that (O-), X is=N-that Y and Z are=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 20
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 21
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-OCH 2- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 22
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CO-O- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 23
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-O-CO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 24
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CO-NH- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 25
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-NH-CO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 26
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-C (CH 3)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 27
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 28
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 29
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 30
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 31
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe a direct key, X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 32
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH=CH-that X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 33
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH ≡ CH-that X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 34
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe that (O-), X and Y are=N-that Z is=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 35
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 36
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-OCH 2- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 37
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CO-O- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 38
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-O-CO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 39
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CO-NH- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 40
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-NH-CO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 41
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 42
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 43
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 44
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 45
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 46
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe a direct key, X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 47
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH=CH-that X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 48
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-C ≡ C-that X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 49
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe that (O-), X and Z are=N-that Y is=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 50
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 51
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-OCH 2- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 52
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CO-O- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 53
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-O-CO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 54
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CO-NH- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 55
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-NH-CO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 56
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 57
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 58
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 59
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N ≡ C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 60
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 61
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe a direct key, X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 62
General formula 1.A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH=CH-that X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 63
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH ≡ CH-, X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 64
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe that (O-), X, Y and Z are=CH-and A oxygen aFor each compound, corresponding to a group in the Table A.Table 65
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 66
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-OCH 2- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 67
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CO-O- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 68
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-O-CO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 69
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CO-NH- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 70
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-NH-CO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 71
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-C (CH 3)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 72
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 73
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 74
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 75
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 76
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe a direct key, X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 77
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH=CH-that X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 78
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-C ≡ C-that X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 79
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe that (O-), X is=N-that Y and Z are=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 80
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 81
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-OCH 2- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 82
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CO-O- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 83
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-O-CO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 84
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CO-NH- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 85
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-NH-CO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 86
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-C (CH 3)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 87
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 88
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 89
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 90
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 91
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe a direct key, X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 92
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH=CH-that X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 93
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH ≡ CH-that X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 94
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe that (O-), X and Y are=N-that Z is=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 95
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 96
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-OCH 2- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 97
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CO-O- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 98
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-O-CO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 99
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CO-NH- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 100
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-NH-CO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 101
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 102
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Y be=N-, Z be with=CH-and A aFor each compound, corresponding to a group in the Table A.Table 103
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 104
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 105
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 106
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe a direct key, X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 107
General formula I .A compound, wherein R 1And R 3Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH=CH-that X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 108
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-C ≡ C-that X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 109
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe that (O-), X and Z are=N-that Y is=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 110
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 111
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-OCH 2- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 112
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CO-O- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 113
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-O-CO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 114
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CO-NH- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 115
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-NH-CO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 116
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 117
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 118
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 119
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 120
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 121
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe a direct key, X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 122
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH=CH-that X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 123
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH ≡ CH-, X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 124
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe that (O-), X, Y and Z are=CH-and A oxygen aFor each compound, corresponding to a group in the Table A.Table 125
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 126
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-OCH 2- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 127
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CO-O- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 128
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-O-CO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 129
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CO-NH- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 130
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-NH-CO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 131
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-C (CH 3)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 132
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 133
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 134
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 135
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 136
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe a direct key, X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 137
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH=CH-that X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 138
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-C ≡ C-that X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 139
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe that (O-), X is=N-that Y and Z are=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 140
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 141
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-OCH 2- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 142
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CO-O- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 143
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-O-CO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 144
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CO-NH- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 145
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-NH-CO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 146
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-C (CH 3)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 147
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 148
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 149
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 150
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 151
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe a direct key, X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 152
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH=CH-that X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 153
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH ≡ CH-that X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 154
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe that (O-), X and Y are=N-that Z is=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 155
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 156
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-OCH 2- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 157
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CO-O- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 158
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-O-CO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 159
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CO-NH- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 160
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-NH-CO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 161
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 162
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 163
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 164
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 165
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 166
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe a direct key, X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 167
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH=CH-that X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 168
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-C ≡ C-that X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 169
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe that (O-), X and Z are=N-that Y is=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 170
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 171
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-OCH 2- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 172
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CO-O- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 173
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-O-CO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 174
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CO-NH- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 175
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-NH-CO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 176
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 177
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 178
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 179
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 180
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 181
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe a direct key, X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 182
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH=CH-that X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 183
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH ≡ CH-, X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 184
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe that (O-), X, Y and Z are=CH-and A oxygen aFor each compound, corresponding to a group in the Table A.Table 185
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 186
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-OCH 2- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 187
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CO-O- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 188
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-O-CO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 189
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CO-NH- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 190
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-NH-CO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 191
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-C (CH 3)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 192
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 193
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 194
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 195
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 196
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe a direct key, X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 197
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH=CH-that X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 198
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-C ≡ C-that X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 199
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe that (O-), X is=N-that Y and Z are=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 200
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 201
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-OCH 2- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 202
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CO-O- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 203
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-O-CO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 204
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CO-NH- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 205
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-NH-CO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 206
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-C (CH 3)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 207
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 208
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 209
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 210
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 211
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe a direct key, X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 212
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH=CH-that X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 213
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH ≡ CH-that X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 214
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe that (O-), X and Y are=N-that Z is=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 215
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 216
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-OCH 2- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 217
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CO-O- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 218
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-O-CO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 219
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CO-NH- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 220
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-NH-CO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 221
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 222
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 223
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 224
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 225
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 226
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe a direct key, X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 227
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH=CH-that X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 228
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-C ≡ C-that X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 229
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe that (O-), X and Z are=N-that Y is=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 230
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 231
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-OCH 2- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 232
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CO-O- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 233
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-O-CO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 234
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CO-NH- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 235
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-NH-CO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 236
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 237
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 238
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 239
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 240
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 241
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe a direct key, X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 242
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH=CH-that X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 243
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH ≡ CH-, X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 244
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe that (O-), X, Y and Z are=CH-and A oxygen aFor each compound, corresponding to a group in the Table A.Table 245
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 246
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-OCH 2- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 247
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CO-O- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 248
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-O-CO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 249
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CO-NH- *( *For with A aBonding), X, Y and Z are=CH-and A aFor a female compound, corresponding to a group in the Table A.Table 250
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-NH-CO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 251
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-C (CH 3)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 252
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 253
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 254
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 255
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 256
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe a direct key, X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 257
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH=CH-that X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 258
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-C ≡ C-that X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 259
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe that (O-), X is=N-that Y and Z are=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 260
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 261
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-OCH 2- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 262
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CO-O- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 263
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-O-CO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 264
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CO-NH- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 265
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-NH-CO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 266
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-C (CH 3)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 267
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 268
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 269
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 270
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 271
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe a direct key, X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 272
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH=CH-that X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 273
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH ≡ CH-that X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 274
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe that (O-), X and Y are=N-that Z is=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 275
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 276
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-OCH 2- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 277
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CO-O- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 278
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-O-CO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 279
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CO-NH- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 280
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-NH-CO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 281
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 282
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 283
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 284
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 285
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 286
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe a direct key, X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 287
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH=CH-that X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 288
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-C ≡ C-that X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 289
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe that (O-), X and Z are=N-that Y is=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 290
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 291
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-OCH 2- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 292
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CO-O- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 293
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-O-CO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 294
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CO-NH- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 295
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-NH-CO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 296
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 297
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 298
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 299
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 300
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 301
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe a direct key, X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 302
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH=CH-that X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 303
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH ≡ CH-, X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 304
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe that (O-), X, Y and Z are=CH-and A oxygen aFor each compound, corresponding to a group in the Table A.Table 305
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 306
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-OCH 2- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 307
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CO-O- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 308
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-O-CO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 309
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CO-NH- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 310
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-NH-CO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 311
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-C (CH 3)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 312
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 313
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 314
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 315
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 316
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe a direct key, X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 317
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH=CH-that X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 318
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-C ≡ C-that X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 319
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe that (O-), X is=N-that Y and Z are=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 320
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 321
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-OCH 2- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 322
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CO-O- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 323
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-O-CO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 324
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CO-NH- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 325
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-NH-CO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 326
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-C (CH 3)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 327
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 328
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 329
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 330
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group in the Table A.Table 331
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe a direct key, X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 332
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH=CH-that X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 333
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH ≡ CH-that X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 334
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe that (O-), X and Y are=N-that Z is=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 335
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 336
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-OCH 2- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 337
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CO-O- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 338
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-O-CO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 339
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CO-NH- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 340
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-NH-CO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 341
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 342
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 343
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 344
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 345
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 346
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe a direct key, X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 347
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH=CH-that X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 348
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-C ≡ C-that X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 349
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe that (O-), X and Z are=N-that Y is=CH-and A to oxygen aFor each compound, corresponding to a group in the Table A.Table 350
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 351
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-OCH 2- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 352
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CO-O- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 353
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-O-CO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 354
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CO-NH- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 355
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-NH-CO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 356
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 357
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 358
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 359
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 360
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group in the Table A.Table 361
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe a direct key, X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 362
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-C (CH 3)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 363
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 364
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 365
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 366
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 367
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe a direct key, X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 368
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-C (CH 3)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 369
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 370
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 371
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 372
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table R.Table 373
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe a direct key, X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 374
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 375
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)- *(U *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 376
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 377
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 378
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 379
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe a direct key, X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 380
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 381
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 382
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 383
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 384
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 385
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe a direct key, X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 386
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-C (CH 3)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 387
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 388
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 389
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 390
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 391
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe a direct key, X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 392
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-C (CH 3)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 393
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 394
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 395
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 396
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 397
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe a direct key, X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 398
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 399
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 400
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 401
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 402
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 403
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe a direct key, X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 404
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 405
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 406
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 407
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 408
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 409
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe a direct key, X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 410
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-C (CH 3)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 411
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 412
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 413
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 414
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 415
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe a direct key, X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 416
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-C (CH 3)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 417
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 418
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6C 5)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 419
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 420
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 421
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe a direct key, X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 422
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 423
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 424
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 425
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 426
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 427
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe a direct key, X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 428
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 429
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 430
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 431
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 432
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 433
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe a direct key, X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 434
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-C (CH 3)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 435
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 436
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 437
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 438
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 439
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe a direct key, X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 440
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-C (CH 3)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 441
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 442
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 443
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 444
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 445
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe a direct key, X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 446
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 447
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 448
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 449
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 450
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 451
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe a direct key, X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 452
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 453
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 454
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 455
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 456
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 457
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe a direct key, X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 458
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-C (CH 3)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 459
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 460
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 461
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 462
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 463
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe a direct key, X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 464
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-C (CH 3)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 465
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 466
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 467
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 468
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 469
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe a direct key, X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 470
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 471
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 472
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 473
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 474
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 475
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe a direct key, X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 476
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 477
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 478
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 479
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 480
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 481
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe a direct key, X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 482
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-C (CH 3)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 483
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 484
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 485
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 486
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 487
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe a direct key, X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 488
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-C (CH 3)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 489
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 490
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 491
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 492
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-CI-C 6H 4)=NO- *( *For with A aBonding), X is=N-that Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 493
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe a direct key, X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 494
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 495
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 496
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 497
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 498
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Y are=N-that Z is=CH-and A aFor each compound, corresponding to a group among the table B.Table 499
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe a direct key, X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 500
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-C (CH 3)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 501
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 502
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 503
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 504
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=NO- *( *For with A aBonding), X and Z are=N-that Y is=CH-and A aFor each compound, corresponding to a group among the table B.Table 505
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 506
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 507
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 508
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 509
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 510
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 511
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 512
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 513
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 514
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 515
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 516
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 517
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 518
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 519
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 520
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 521
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 522
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 523
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 524
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 525
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 526
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 527
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 528
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be oxygen, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 529
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 530
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 531
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 532
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 533
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 534
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 535
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 536
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 537
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 538
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 539
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 540
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 541
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 542
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 543
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 544
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 545
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 546
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 547
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 548
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 549
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 550
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 551
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 552
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U be amino (NH-) and V be sulphur, W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 553
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 554
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 555
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 556
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 557
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 558
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 559
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 560
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 561
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 562
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 563
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 564
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U is that oxygen and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 565
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 566
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 567
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X, Y and Z are=CH-and A aFor each compound, corresponding to a group among the table B.Table 568
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 569
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 570
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X is that (NH-), Y and Z are=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 571
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 572
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 573
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X and Y are that (NH-), Z is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 574
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (C 6H 5)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 575
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (2-Cl-C 6H 4)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.Table 576
General formula I .A compound, wherein R 1And R 2Be methyl, R 3Be hydrogen, U and V are amino (NH-), W aBe-CH 2O-N=C (CH 3)-C (4-Cl-C 6H 4)=N- *( *For with A aBonding), X and Z are that (NH-), Y is=CH-and A amino aFor each compound, corresponding to a group among the table B.
Table A
Sequence number ?A a Sequence number ?A a Sequence number ?A a
1 Phenyl 127 2, the 5-dichlorophenyl 253 2-bromo-4-chloro-phenyl-
2 The 2-fluorophenyl 128 3, the 4-dichlorophenyl 254 2-bromo-4-fluorophenyl
3 The 3-fluorophenyl 129 3, the 5-dichlorophenyl 255 3-bromo-4-chloro-phenyl-
4 The 4-fluorophenyl 130 2,3, the 4-trichlorophenyl 256 3-chloro-4-fluorophenyl
5 The 2-chloro-phenyl- 131 2,3, the 5-trichlorophenyl 257 3-fluoro-4-chloro-phenyl-
6 2-chloro-4-fluorophenyl 132 2,3, the 6-trichlorophenyl 258 The 2-cyano-phenyl
7 2-chloro-5-fluorophenyl 133 3,4, the 5-trichlorophenyl 259 The 4-cyano-phenyl
8 2-chloro-6-fluorophenyl 134 The 2-bromophenyl 260 The 2-nitrophenyl
9 The 2-ethylphenyl 135 The 3-bromophenyl 261 The 2-aminomethyl phenyl
10 The 3-ethylphenyl 136 The 4-bromophenyl 262 The 3-aminomethyl phenyl
11 3,5-diethyl phenyl 137 2, the 4-dibromo phenyl 263 The 4-aminomethyl phenyl
12 2-n-propyl phenyl 138 3-bromo-4-fluorophenyl 264 2, the 4-3,5-dimethylphenyl
13 The 3-chloro-phenyl- 139 3-bromo-4-p-methoxy-phenyl 265 2, the 6-3,5-dimethylphenyl
14 The 4-chloro-phenyl- 140 The 2-iodophenyl 266 3, the 4-3,5-dimethylphenyl
15 The 2,4 dichloro benzene base 141 2-chloro-4-bromophenyl 267 3, the 5-3,5-dimethylphenyl
16 2,3, the 4-trimethylphenyl 142 2-methyl-4-Phenoxyphenyl 268 3-n-hexyloxy phenyl
17 2 143 2-methyl-4-benzyloxy phenyl 269 4-n-hexyloxy phenyl
18 2,3, the 6-trimethylphenyl 144 2-methyl-3-chloro-phenyl- 270 3-allyloxy phenyl
19 2 145 2-methyl-4-chloro-phenyl- 271 4-is different-the propoxy-phenyl
Sequence number ?A a Sequence number ?A a Sequence number ?A a
20 2,4, the 6-trimethylphenyl 146 2-methyl-5-chloro phenyl 272 The 2-phenyl
21 3,4, the 5-trimethylphenyl 147 2-methyl-6-chloro-phenyl- 273 The 3-phenyl
22 3-n-base phenyl 148 2-methyl-4-fluorophenyl 274 The 4-phenyl
23 4-n-propyl group phenyl 149 2-methyl-3-bromophenyl 275 The 2-Phenoxyphenyl
24 The 2-isopropyl phenyl 150 2-methyl-4-p-methoxy-phenyl 276 The 4-Phenoxyphenyl
25 The 3-isopropyl phenyl 151 2-methyl-5-p-methoxy-phenyl 2?77 The 1-naphthyl
26 The 4-isopropyl phenyl 152 2-methyl-6-p-methoxy-phenyl 278 The 2-naphthyl
27 2,3-two-isopropyl phenyl 153 2-methyl-4-isopropyl phenyl 279 The 9-anthryl
28 3,5-two-isopropyl phenyl 154 2-methyl-2, the 5-Dimethoxyphenyl 280 2-fluoro-4-Phenoxyphenyl
29 The 4-n-butylphenyl 155 The 2-p-methoxy-phenyl 281 3-fluoro-4-Phenoxyphenyl
30 The 4-secondary butyl phenenyl 156 The 3-p-methoxy-phenyl 282 4-fluoro-4-Phenoxyphenyl
31 The 4-isobutyl phenenyl 157 The 4-p-methoxy-phenyl 283 2-chloro-4-Phenoxyphenyl
32 2-methyl-4-tert-butyl-phenyl 158 2-chloro-5-aminomethyl phenyl 284 4-chloro-4-Phenoxyphenyl
33 2-methyl-6-tert butyl phenyl 159 2-chloro-4-isopropyl phenyl 285 2-bromine 4-Phenoxyphenyl
34 2-methyl-4-isopropyl phenyl 160 3-n-propoxy-phenyl 286 3-bromo-4 Phenoxyphenyls
35 2-methyl-4-cyclohexyl phenyl 161 The 3-n-butoxy phenyl 287 4-bromo-4-Phenoxyphenyl
36 2-methyl-4-phenyl 162 The 3-isobutoxy phenyl 288 3-methyl-4-Phenoxyphenyl
37 2 methyl-4-benzyl phenyl 163 3-n-pentyloxy phenyl 289 4-methyl-4-Phenoxyphenyl
38 Uncle 3--Ding-4-phenoxy group-phenyl 164 4-(imidazoles-1 '-yl) phenyl 290 2, the 5-3,5-dimethylphenyl
39 2-methoxyl group-4-Phenoxyphenyl 165 4-(piperazine-1 '-yl) phenyl 291 2-methyl-4-iodophenyl
Sequence number ?A a Sequence number ?A a Sequence number ?A a
40 3-methoxyl group-4-Phenoxyphenyl 166 4-(morpholine-1 '-yl) phenyl 292 2-methyl-5-iodophenyl
41 4-methoxyl group-4-Phenoxyphenyl 167 4-(piperidines-1 '-yl) phenyl 293 2,5-dimethyl-4-iodophenyl
42 3-5-two chloro-4-Phenoxyphenyls 168 4-(pyridyl-2 '-the oxygen base) phenyl 294 2-methyl-5-isopropyl phenyl
43 3-4-two chloro-4-Phenoxyphenyls 169 2-cyclopropyl phenyl 295 6-ethyl-2-pyridyl
44 4-ethyl-4-Phenoxyphenyl 170 3-cyclopropyl phenyl 296 6-n-propyl-2-pyridyl
45 4-sec.-propyl-4-Phenoxyphenyl 171 3-cyclohexyl phenyl 297 6-sec.-propyl-2-pyridyl
46 2, the 4-Dimethoxyphenyl 172 The 4-cyclohexyl phenyl 298 6-normal-butyl-2-pyridine
47 2, the 5-Dimethoxyphenyl 173 4-oxyethane phenyl 299 The 6-tertiary butyl-2-pyridine
48 3, the 6-Dimethoxyphenyl 174 4-(pyridine-2-yl) phenyl 300 6-n-pentyl-2-pyridine
49 2,3, the 4-trimethoxyphenyl 175 3-(pyridine-2-yl) phenyl 301 6-n-hexyl-2-pyridine
50 The 2-ethoxyl phenenyl 176 4-(pyridin-3-yl) phenyl 302 6-phenyl-2-pyridine
51 The 2-isopropyl phenyl 177 3-(pyridin-3-yl) phenyl 303 6-benzyl-2-pyridine
52 2-methyl-3-isopropyl phenyl 178 3-(pyrimidine-2-base) phenyl 304 6-trifluoromethyl-2-pyridyl
53 2-methyl-5-isopropyl phenyl 179 The 3-Phenoxyphenyl 305 6-methoxyl group 2-pyridyl
54 2-benzyloxy phenyl 180 2-fluoro-3-Phenoxyphenyl 306 6-chloro-2-pyridyl
55 3-benzyloxy phenyl 181 2-methyl-3-Phenoxyphenyl 307 3,6-dimethyl-2-pyridyl
56 4-benzyloxy phenyl 182 6-methyl-2-pyridyl 308 3,6-diethyl-2-pyridyl
57 4,6-dimethyl-2-pyridine 183 5,6-dimethyl-2-pyridyl 309 4-phenyl-6-methyl-2-pyridyl
58 4,6-phenylbenzene-2-pyridine 184 3,4-two chloro-6-methyl-pyridyl 310 3,4,5-three chloro-6-phenyl-2-pyridyl
Sequence number ?A a Sequence number ?A a Sequence number ?A a
59 4-trifluoromethyl-6-methyl-6-2-pyridyl 185 3-ethanoyl-4,6-dimethyl-2-pyridyl 311 3-cyano group-6-methyl-2-pyridyl
60 3-cyano group-6-ethyl-2-pyridyl 186 3-cyano group-6-n-propyl-2-pyridyl 312 3-cyano group-sec.-propyl-2-pyridyl
61 3-cyano group-6-cyclopropyl-2-pyridyl 187 3-cyano group-6-normal-butyl-2-pyridyl 313 3-cyano group-6-the tertiary butyl-2-pyridyl
62 3-cyano group-6-cyclohexyl-2-pyridyl 188 3-cyano group-6-phenyl-2-pyridyl 314 3-methoxycarbonyl-6-sec.-propyl-2-pyridyl
63 3-ethoxy carbonyl-6-sec.-propyl-2-pyridyl 189 3-cyano group-4,6-dimethyl-2-pyridyl 315 3,5, the 6-trichloro-2-pyridyl
64 5-trifluoromethyl-2-pyridyl 190 3-chloro-5-trifluoromethyl-2-pyridyl 316 6-cyclopropyl-2-pyridyl
65 6-bromo-2-pyridyl 191 4-trifluoromethyl-5-chloro-2-pyridyl 317 The 4-tertiary butyl-2-pyridyl
66 3, two (the trifluoromethyl)-2-pyridyl of 6- 192 5-trifluoromethyl-2-pyridyl 318 3-fluoro-2-pyridyl
67 3-chloro-2-pyridyl 193 4-bromo-2-pyridyl 319 5-methyl-2-pyridyl
68 3-fluoro-5-trifluoromethyl-2-pyridyl 194 3,6-two chloro-5-trifluoromethyl-2-pyridyl 320 6-chloro-4-cyano group-2-pyridyl
69 4,6-two fluoro-2-pyridyl 195 3,5 two chloro-6-fluoro-2-pyridyl 321 6-methoxyl group-3-nitro-2-pyridyl
70 4-cyano group-6-fluorine 2-pyridyl 196 4-cyano group-3,5,6-three fluoro-2-pyridyl 322 6-chloro-5-nitro-2-pyridyl
71 4,6 dicyanos-2-pyridyl 197 5-trifluoromethyl-2-pyridyl 323 5-cyano group-2-pyridyl
Sequence number ?A a Sequence ?A a Sequence number ?A a
72 5-bromo-4-trifluoromethyl-2-pyridyl 198 3-nitro-5-trifluoromethyl-2-pyridyl 324 5-formamido group-2-pyridyl
73 5-amino-2-pyridyl 199 5-nitro-2-pyridyl 325 4-methyl-5-nitro-2-pyridyl
74 5-difluoromethyl-2-pyridyl 200 5-methyl fluoride-2-pyridyl 326 5-methoxycarbonyl-2-pyridyl
75 5-chloro-6-methyl-2-pyridyl 201 5,6-two chloro-2-pyridyl 327 6-bromo-5-chloro-2-pyridyl
76 5-chloro-6-acetoxyl group-2-pyridyl 202 5-bromo-6-fluoro-2-pyridyl 328 5-bromo-6-cyano group-2-pyridyl
77 5-bromo-6-hydroxyl-2-pyridyl 203 5-bromo-6-methoxyl group-2-pyridyl 329 5,6-two bromo-2-pyridyl
78 6-phenoxy group-2-pyridyl 204 4-phenyl-2-pyridyl 330 4-phenoxy group-2-pyridyl
79 6-hydroxyl-2-pyridyl 205 6-hydroxyl-2-pyridyl 331 6-oxyethyl group-2-pyridyl
80 6-benzyloxy-2-pyridyl 206 4-benzyloxy-2-pyridyl 332 4, two (the trifluoromethyl)-2-pyridyl of 6-
81 6-formyl radical-2-pyridyl 207 6-amino-2-pyridyl 333 4-amino-2-pyridyl
82 4-carboxyl-2-pyridyl 208 3-bromo-5-trifluoromethyl-2-pyridyl 334 6-methyl-3-nitro-2-pyridyl
83 3-nitro-2-pyridyl 209 3-fluoro-5-trifluoromethyl-2-pyridyl 335 The 3-pyridyl
84 2-fluoro-3-pyridyl 210 4-trifluoromethyl-3-pyridyl 336 5-methyl-3-pyridyl
85 6-methoxyl group-3-pyridyl 211 4-cyano group-2,5,6-three fluoro-3-pyridyl 337 The 4-pyridyl
86 2-chloro-4-pyridyl 212 3-trifluoromethyl-4-pyridyl 338 2-chloro-6-fluoro-4-pyridyl
Sequence number ?A a Sequence number ?A a Sequence number ?A a
87 2,3,5,6-tetrafluoro-4-pyridyl 213 The 2-pyrimidyl 339 4,6-dimethyl-2-pyrimidyl
88 4-trifluoromethyl-2-pyrimidyl 214 4,5,6-trimethylammonium-2-pyrimidyl 340 4-benzyl-6-methyl-2-pyrimidyl
89 4-methyl-6-phenyl-pyrimidine base 215 4,6-dimethyl-5-chloro-2-pyrimidyl 341 4-fluoro-2-pyrimidyl
90 5-methyl-2-pyrimidyl 216 4,6-three fluoro-2-pyrimidyl 342 The 4-pyrimidyl
91 2,6-dimethyl-4-pyrimidyl 217 2, two (the trifluoromethyl)-4-pyrimidyl of 6- 343 2-chloromethyl-6-methyl-4-pyrimidyl
92 2-methyl-6-chloromethyl-4-pyrimidyl 218 2-sec.-propyl-6-methyl-4-pyrimidyl 344 2-sec.-propyl-6-chloromethyl-4-pyrimidyl
93 2-cyclopropyl-6-chloromethyl-4-pyrimidyl 219 2-cyclopropyl-6-methyl-4-pyrimidyl 345 2-methyl-6-methoxymethyl-4 pyrimidyl
94 2-sec.-propyl-6-methoxyl group-methyl-4-pyrimidyl 220 2-phenyl-4-pyrimidyl 346 2,5-dimethyl-4-pyrimidyl
95 2-methylthio group-6-trifluoromethyl 4-pyrimidyl 221 2-methylthio group-5-chloro-6-trifluoromethyl-4-pyrimidyl 347 2-methylthio group-5-n-octyl-6-methyl-4-pyrimidyl-4-pyrimidyl
96 2-methyl-6-trifluoromethyl-4-pyrimidyl 222 2-n-propyl-6-trifluoromethyl-4-pyrimidyl 348 2-sec.-propyl-6-trifluoromethyl-4-pyrimidyl
97 2-n-propyl-4-methyl-4-pyrimidyl 223 The 2-tertiary butyl-6-trifluoromethyl-4-pyrimidyl 349 2-methyl-5-chloro-6-trifluoromethyl-4-pyrimidyl
98 2-n-propyl-5-chloro-6-trifluoromethyl-4-pyrimidyl 224 2-sec.-propyl-5-chloro-6-trifluoromethyl-4-pyrimidyl 350 The 2-tertiary butyl-5-chloro-6-trifluoromethyl-4-pyrimidyl
Sequence number ?A a Sequence number ?A a Sequence number ?A a
99 2-2-chloro-4-pyrimidyl 225 5-methoxyl group-4-pyrimidyl 351 6-trifluoromethyl-4-pyrimidyl
100 2-chloro-6-trichloromethyl-4-pyrimidyl 226 2,6-two chloro-4-pyrimidyl 352 2-phenyl-6-trifluoromethyl-4-pyrimidyl
101 2-methylthio group-6-difluoro-methoxy-4-pyrimidyl 227 2-ethyl-6-trifluoromethyl-4-pyrimidyl 353 2-cyclopropyl-6-trifluoromethyl-4-pyrimidyl
102 2-phenyl-6-trifluoromethyl-4-pyrimidyl 228 2-methylthio group-5-chloro-6-methoxyl group-4-pyrimidyl 354 2-dimethylamino-5-normal-butyl-6-methyl-4-pyrimidyl
103 2-methylamino-5-nitro-6-methyl-4-pyrimidyl 229 The 2-quinolyl 355 3-methyl-2-quinolyl
104 4-methyl-2-quinolyl 230 4-ethyl-2-quinolyl 356 4-phenyl-2-quinolyl
105 6-methyl-2 quinolyl 231 6-chloro-2-quinolyl 357 8-methyl-2-quinolyl
106 8-chloro-2-quinolyl 232 4-ethoxy carbonyl-2-quinolyl 358 3,4-dimethyl-2-quinolyl
107 4-methyl-8-methoxyl group-2-quinolyl 233 4-phenyl-8-oxyethyl group-2-quinolyl 359 4-methyl-8-chloro-2-quinolyl
108 4-methyl-8-fluoro-2-quinolyl 234 The 4-quinolyl 360 2-methyl-4-quinolyl
109 2-trichloromethyl-4-quinolyl 235 2-trifluoromethyl-2-quinolyl 361 2-sec.-propyl-4-quinolyl
110 2-n-pentyl-4-quinolyl 236 2-phenyl-4-quinolyl 362 2-methoxycarbonyl-4-quinolyl
111 2,6-dimethyl-4-quinolyl 237 2-methyl-6-chloro-4-quinolyl 363 2-methyl-6-fluoro-4-quinolyl
112 The 8-quinolyl 238 2-methyl-8-quinolyl 364 5,7-two chloro-8-quinolyls
Sequence number ?A a Sequence number ?A a Sequence number ?A a
113 The 2-pyrazinyl 239 6-chloro-2-pyrazinyl 365 5-methyl-2-pyrazinyl-
114 The 3-pyridazinyl 240 5-chloro-3-pyridazinyl 366 The 2-thienyl
115 The 3-thienyl 241 4-chloro-3-thienyl 367 2-chloro-3-thienyl
116 5-chloro-3-thienyl 242 4-chloro-2-thienyl 368 The 2-quinoxalinyl
117 3-methyl-2-quinoxalinyl 243 7,8-dimethyl-2-quinoxalinyl 369 7,8-two chloro-2-quinoxalinyls
118 7-methyl-2-quinoxalinyl 244 8-methyl-2-quinoxalinyl 370 7-methoxyl group-2-quinoxalinyl
119 3-phenyl-5-isoxazolyl 245 The 2-benzoxazolyl group 371 The 2-[4-morpholinodithio base
120 1-phenyl-pyrazole-4-base 246 2-n-propyl-6-methyl-4-pyrimidyl 372 2-cyclopentyl-6-trifluoromethyl-4-pyrimidyl
121 2-cyclohexyl-6-trifluoromethyl-4-pyrimidyl 247 2-cyclohexyl-5-chloro-6-methyl-4-pyrimidyl 373 2-n-propyl-5-chloro-6-methyl 4-pyrimidyl
122 Pyrazol-1-yl 248 4-chlorine pyrazol-1-yl 374 3-1-base
123 1,2-benzisoxa azoles-3-base 249 1-(4-chloro-phenyl-)-pyrazoles-4-base 375 1-(4-aminomethyl phenyl)-pyrazoles-4-base
124 1-phenylpyrazole-4-base 250 1-methyl-3-trifluoromethyl-pyrazoles-5-base 376 1-(4-fluorophenyl)-pyrazoles-4-base
125 The different azoles of 5-phenyl-3-base 251 Benzotriazole-1-base 377 3-cyano group-5 nitros-2-pyridyl
Table D.1
Sequence number ?A a
01 ?1-CH 3-pyrroles-3-base
02 ?1-CH(CH 3) 2-pyrroles-3-base
03 ?1-C(CH 3) 3-pyrroles-3-base
04 1-cyclopropyl pyrroles-3-base
05 ?1-C 6H 5-pyrroles-3-base
06 ?1-(2-CH 3-C 6H 4) pyrroles-3-base
07 ?1-(3-CH 3-C 6H 4) pyrroles-3-base
08 ?1-(4-CH 3-C 6H 4) pyrroles-3-base
09 ?1-(3-OCH 3-C 6H 4) pyrroles-3-base
10 ?1-(4-OCH 3-C 6H 4) pyrroles-3-base
11 ?1-(4-NO 2-C 6H 4) pyrroles-3-base
12 ?1-(3-NO 2-C 6H 4) pyrroles-3-base
13 ?1-(4-CN-C 6H 4) pyrroles-3-base
14 ?1-(3-CN-C 6H 4) pyrroles-3 base
15 ?1-(3-CF 3-C 6H 4) pyrroles-3-base
16 ?1-(4-CF 3-C 6H 4) pyrroles-3-base
17 ?1-(4-C(CH 3) 3-C 6H 4) pyrroles-3-base
18 ?1-(4-C 6H 5-C 6H 4) pyrroles-3-base
19 ?1-(2-Cl-C 6H 4) pyrroles-3-base
20 ?1-(3-Cl-C 6H 4) pyrroles-3-base
21 ?1-(4-Cl-C 6H 4) pyrroles-3-base
22 ?1-(2-Br-C 6H 4) pyrroles-3-base
23 ?1-(3-Br-C 6H 4) pyrroles-3-base
24 ?1-(4-Br-C 6H 4) pyrroles-3-base
25 ?1-(2-F-C 6H 4) pyrroles-3-base
26 ?1-(3-F-C 6H 4) pyrroles-3-base
2?7 ?1-(4-F-C 6H 4) pyrroles-3-base
28 ?1-(2，4-Cl 2-C 6H 3) pyrroles-3-base
29 ?1-(2，5-Cl 2-C 6H 3) pyrroles-3-base
30 ?1-(2，6-Cl 2-C 6H 3) pyrroles-3-base
31 ?1-(3，4-Cl 2-C 6H 3) pyrroles-3-base
32 ?1-(2，4-F 2-C 6H 3) pyrroles-3-base
33 ?1-(2，5-F 2-C 6H 3) pyrroles-3-base
34 ?1-(2，6-F 2-C 6H 3) pyrroles-3-base
35 ?1-(3，4-F 2-C 6H 3) pyrroles-3-base
36 ?1-(2-Cl，5-OCH 3-C 6H 3) pyrroles-3-base
37 ?1-(2-Cl，5-CH 3-C 6H 3) pyrroles 3-base
38 ?1-(5-Cl，2-OCH 3-C 6H 3) pyrroles-3-base
39 ?1-(5-Cl，2-CH 3-C 6H 3) pyrroles-3-base
Sequence number ?A a
40 ?1-[2，5-(CH 3) 2-C 6H 3] pyrroles-3-base
41 ?1-CH 3-pyrroles-2-base
42 ?1-CH(CH 3) 2-pyrroles-2-base
43 ?1-C(CH 3) 3-pyrroles-2-base
44 1-cyclopropyl pyrroles-2-base
45 ?1-C 6H 5-pyrroles-2-base
46 ?1-(2-CH 3-C 6H 4) pyrroles-2-base
47 ?1-(3-CH 3-C 6H 4) pyrroles-2-base
48 ?1-(4-CH 3-C 6H 4) pyrroles-2-base
49 ?1-(3-OCH 3-C 6H 4) pyrroles-2-base
50 ?1-(4-OCH 3-C 6H 4) pyrroles-2-base
51 ?1-(4-NO 2-C 6H 4) pyrroles-2-base
52 ?1-(3-NO 2-C 6H 4) pyrroles-2-base
53 ?1-(4-CN-C 6H 4) pyrroles-2-base
54 ?1-(3-CN-C 6H 4) pyrroles-2-base
55 ?1-(3-CF 3-C 6H 4) pyrroles-2-base
56 ?1-(4-CF 3-C 6H 4) pyrroles-2-base
57 ?1-(4-C(CH 3) 3-C 6H 4) pyrroles-2-base
58 ?1-(4-C 6H 5-C 6H 4) pyrroles-2-base
59 ?1-(2-Cl-C 6H 4) pyrroles-2-base
60 ?1-(3-Cl-C 6H 4) pyrroles-2-base
61 ?1-(4-Cl-C 6H 4) pyrroles-2-base
62 ?1-(2-Br-C 6H 4) pyrroles-2-base
63 ?1-(3-Br-C 6H 4) pyrroles-2-base
64 ?1-(4-Br-C 6H 4) pyrroles-2-base
65 ?1-(2-F-C 6H 4) pyrroles-2-base
66 ?1-(3-F-C 6H 4) pyrroles-2-base
67 ?1-(4-F-C 6H 4) pyrroles-2-base
68 ?1-(2，4-Cl 2-C 6H 3) pyrroles-2-base
69 ?1-(2，5-Cl 2-C 6H 3) pyrroles-2-base
70 ?1-(2，6-Cl 2-C 6H 3) pyrroles-2-base
71 ?1-(3，4-Cl 2-C 6H 3) pyrroles-2-base
72 ?1-(2，4-F 2-C 6H 3) pyrroles-2-base
73 ?1-(2，5-F 2-C 6H 3) pyrroles-2-base
74 ?1-(2，6-F 2-C 6H 3) pyrroles-2-base
75 ?1-(3，4-F 2-C 6H 3) pyrroles-2-base
76 ?1-(2-Cl，5-OCH 3-C 6H 3) pyrroles-2-base
77 ?1-(2-Cl，5-CH 3-C 6H 3) pyrroles-2-base
78 ?1-(5-Cl，2-OCH 3-C 6H 3) pyrroles-2-base
79 ?1-(5-Cl，2-CH 3-C 6H 3) pyrroles-2-base
80 ?1-[2，5-(CH 3) 2-C 6H 3] pyrroles-2-base
Sequence number ?A a
81 5-furans-2-base
82 5-furans-2-base
83 5-furans-2-base
84 5-cyclopropyl furans-2-base
85 ?5-C 6H 5-furans-2-base
86 ?5-(2-CH 3-C 6H 4) furans-2-base
87 ?5-(3-CH 3-C 6H 4) furans-2-base
88 ?5-(4-CH 3-C 6H 4) furans-2 base
89 ?5-(3-OCH 3-C 6H 4) furans-2-base
90 ?5-(4-OCH 3-C 6H 4) furans-2-base
91 ?5-(4-NO 2-C 6H 4) furans-2-base
92 ?5-(3-NO 2-C 6H 4) furans-2-base
93 ?5-(4-CN-C 6H 4) furans-2-base
94 ?5-(3-CN-C 6H 4) furans-2-base
95 ?5-(3-CF 3-C 6H 4) furans-2-base
96 ?5-(4-CF 3-C 6H 4) furans-2-base
97 ?5-(4-C(CH 3) 3-C 6H 4) furans-2-base
98 ?5-(4-C 6H 5-C 6H 4) furans-2-base
99 ?5-(2-Cl-C 6H 4) furans-2-base
100 ?5-(3-Cl-C 6H 4) furans-2-base
101 ?5-(4-Cl-C 6H 4) furans-2-base
102 ?5-(2-Br-C 6H 4) furans-2-base
103 ?5-(3-Br-C 6H 4) furans 2-base
104 ?5-(4-Br-C 6H 4) furans-2-base
105 ?5-(2-F-C 6H 4) furans-2-base
106 ?5-(3-F-C 6H 4) furans-2-base
107 ?5-(4-F-C 6H 4) furans-2-base
108 ?5-(2，4-Cl 2-C 6H 3) furans-2-base
109 ?5-(2，5-Cl 2-C 6H 3) furans-2-base
110 ?5-(2，6-Cl 2-C 6H 3) furans-2-base
111 ?5-(3，4-Cl 2-C 6H 3) furans-2-base
112 ?5-(2，4-F 2-C 6H 3) furans-2-base
113 ?5-(2，5-F 2-C 6H 3) furans-2-base
114 ?5-(2，6-F 2-C 6H 3) furans-2-base
115 ?5-(3，4-F 2-C 6H 3) furans-2-base
116 ?5-(2-Cl，5-OCH 3-C 6H 3) furans-2-base
117 ?5-(2-Cl，5-CH 3-C 6H 3) furans-2-base
118 ?5-(5-Cl，2-OCH 3-C 6H 3) furans-2-base
119 ?5-(5-Cl，2-CH 3-C 6H 3) furans-2-base
120 ?5-[2，5-(CH 3) 2--C 6H 3] furans-2-base
121 ?4-CH 3-furans-2-base
Sequence number ?A a
122 ?4-CH(CH 3) 2-furans-2-base
123 ?4-C(CH 3) 3-furans-2-base
124 4-cyclopropyl furans-2-base
125 ?4-C 6H 5-furans-2-base
126 ?4-(2-CH 3-C 6H 4) furans-2-base
127 ?4-(3-CH 3-C 6H 4) furans-2-base
128 ?4-(4-CH 3-C 6H 4) furans-2-base
129 ?4-(3-OCH 3-C 6H 4) furans-2-base
130 ?4-(4-OCH 3-C 6H 4) furans-2-base
131 ?4-(4-NO 2-C 6H 4) furans-2-base
132 ?4-(3-NO 2-C 6H 4) furans-2-base
133 ?4-(4-CN-C 6H 4) furans-2-base
134 ?4-(3-CN-C 6H 4) furans-2-base
135 ?4-(3-CF 3-C 6H 4) furans-2-base
136 ?4-(4-CF 3-C 6H 4) furans-2-base
137 ?4-(4-C(CH 3) 3-C 6H 4) furans-2-base
138 ?4-(4-C 6H 5-C 6H 4) furans-2-base
139 ?4-(2-Cl-C 6H 4) furans-2-base
140 ?4-(3-Cl-C 6H 4) furans-2-base
141 ?4-(4-Cl-C 6H 4) furans-2-base
142 ?4-(2-Br-C 6H 4) furans-2-base
143 ?4-(3-Br-C 6H 4) furans-2-base
144 ?4-(4-Br-C 6H 4) furans-2-base
145 ?4-(2-F-C 6H 4) furans-2-base
146 ?4-(3-F-C 6H 4) furans-2-base
147 ?4-(4-F-C 6H 4) furans-2-base
148 ?4-(2，4-Cl 2-C 6H 3) furans-2-base
149 ?4-(2，5-Cl 2-C 6H 3) furans-2-base
150 ?4-(2，6-Cl 2-C 6H 3) furans-2-base
151 ?4-(3，4-Cl 2-C 6H 3) furans-2-base
152 ?4-(2，4-F 2-C 6H 3) furans-2-base
153 ?4-(2，5-F 2-C 6H 3) furans-2-base
154 ?4-(2，6-F 2-C 6H 3) furans-2-base
155 ?4-(3，4-F 2-C 6H 3) furans-2-base
156 ?4-(2-Cl，5-OCH 3-C 6H 3) furans-2-base
157 ?4-(2-Cl，5-CH 3-C 6H 3) furans-2-base
158 ?4-(5-Cl，2-OCH 3-C 6H 3) furans-2-base
159 ?4-(5-Cl，2-CH 3-C 6H 3) furans-2-base
160 ?4-[2，5-(CH 3) 2-C 6H 3] furans-2-base
161 ?5-CH 3-thiophene-2-base
162 ?5-CH(CH 3) 2-thiophene-2 base
Sequence number ?A a
163 ?5-C(CH 3) 3-thiophene-2-base
164 5-cyclopropyl thiophene-2-base
165 ?5-C 6H 5-thiophene-2-base
166 ?5-(2-CH 3-C 6H 4) thiophene-2-base
167 ?5-(3-CH 3-C 6H 4) thiophene-2-base
168 ?5-(4-CH 3-C 6H 4) thiophene-2-base
169 ?5-(3-OCH 3-C 6H 4) thiophene-2-base
170 ?5-(4-OCH 3-C 6H 4) thiophene-2-base
171 ?5-(4-NO 2-C 6H 4) thiophene-2-base
172 ?5-(3-NO 2-C 6H 4) thiophene-2-base
173 ?5-(4-CN-C 6H 4) thiophene-2-base
174 ?5-(3-CN-C 6H 4) thiophene-2-base
175 ?5-(3-CF 3-C 6H 4) thiophene-2-base
176 ?5-(4-CF 3-C 6H 4) thiophene-2-base
177 ?5-(4-C(CH 3) 3-C 6H 4) thiophene-2-base
178 ?5-(4-C 6H 5-C 6H 4) thiophene-2-base
179 ?5-(2-Cl-C 6H 4) thiophene-2-base
180 ?5-(3-Cl-C 6H 4) thiophene-2-base
181 ?5-(4-Cl-C 6H 4) thiophene-2-base
182 ?5-(2-Br-C 6H 4) thiophene-2-base
183 ?5-(3-Br-C 6H 4) thiophene-2-base
184 ?5-(4-Br-C 6H 4) thiophene-2-base
185 ?5-(2-F-C 6H 4) thiophene-2-base
186 ?5-(3-F-C 6H 4) thiophene-2-base
187 ?5-(4-F-C 6H 4) thiophene-2-base
188 ?5-(2，4-Cl 2-C 6H 3) thiophene-2-base
189 ?5-(2，5-Cl 2-C 6H 3) thiophene-2-base
190 ?5-(2，6-Cl 2-C 6H 3) thiophene-2-base
191 ?5-(3，4-Cl 2-C 6H 3) thiophene-2-base
192 ?5-(2，4-F 2-C 6H 3) thiophene-2 base
193 ?5-(2，5-F 2-C 6H 3) thiophene-2-base
194 ?5-(2，6-F 2-C 6H 3) thiophene-2-base
195 ?5-(3，4-F 2-C 6H 3) thiophene-2-base
196 ?5-(2-Cl，5-OCH 3-C 6H 3) thiophene-2-base
197 ?5-(2-Cl，5-CH 3-C 6H 3) thiophene-2-base
198 ?5-(5-Cl，2-OCH 3-C 6H 3) thiophene-2-base
199 ?5-(5-Cl，2-CH 3-C 6H 3) thiophene-2-base
200 ?5-[2，5-(CH 3) 2-C 6H 3] thiophene-2-base
201 ?4-CH 3-thiophene-2-base
202 ?4-CH(CH 3) 2-thiophene-2-base
203 ?4-C(CH 3) 3-thiophene-2-base
Sequence number ?A a
204 4-cyclopropyl thiophene-2-base
205 ?4-C 6H 5-thiophene-2-base
206 ?4-(2-CH 3-C 6H 4) thiophene-2-base
207 ?4-(3-CH 3-C 6H 4) thiophene-2-base
208 ?4-(4-CH 3-C 6H 4) thiophene-2-base
209 ?4-(3-OCH 3-C 6H 4) thiophene-2-base
210 ?4-(4-OCH 3-C 6H 4) thiophene-2-base
211 ?4-(4-NO 2-C 6H 4) thiophene-2-base
212 ?4-(3-NO 2-C 6H 4) thiophene-2-base
213 ?4-(4-CN-C 6H 4) thiophene-2-base
214 ?4-(3-CN-C 6H 4) thiophene-2-base
215 ?4-(3-CF 3-C 6H 4) thiophene-2-base
216 ?4-(4-CF 3-C 6H 4) thiophene-2-base
217 ?4-(4-C(CH 3) 3-C 6H 4) thiophene-2-base
218 ?4-(4-C 6H 5-C 6H 4) thiophene-2-base
219 ?4-(2-Cl-C 6H 4) thiophene-2-base
220 ?4-(3-Cl-C 6H 4) thiophene-2-base
221 ?4-(4-Cl-C 6H 4) thiophene-2-base
222 ?4-(2-Br-C 6H 4) thiophene-2-base
223 ?4-(3-Br-C 6H 4) thiophene-2-base
224 ?4-(4-Br-C 6H 4) thiophene-2-base
225 ?4-(2-F-C 6H 4) thiophene-2-base
226 ?4-(3-F-C 6H 4) thiophene-2-base
227 ?4-(4-F-C 6H 4) thiophene-2-base
228 ?4-(2，4-Cl 2-C 6H 3) thiophene-2-base
229 ?4-(2，5-Cl 2-C 6H 3) thiophene-2-base
230 ?4-(2，6-Cl 2-C 6H 3) thiophene-2-base
231 ?4-(3，4-Cl 2-C 6H 3) thiophene-2-base
232 ?4-(2，4-F 2-C 6H 3) thiophene-2-base
233 ?4-(2，5-F 2-C 6H 3) thiophene-2-base
234 ?4-(2，6-F 2-C 6H 3) thiophene-2-base
235 ?4-(3，4-F 2-C 6H 3) thiophene-2-base
236 ?4-(2-Cl，5-OCH 3-C 6H 3) thiophene-2-base
237 ?4-(2-Cl，5-CH 3-C 6H 3) thiophene-2-base
238 ?4-(5-Cl，2-OCH 3-C 6H 3) thiophene-2-base
239 ?4-(5-Cl，2-CH 3-C 6H 3) thiophene-2-base
240 ?4-[2，5-(CH 3) 2-C 6H 3] thiophene-2-base
241 ?2-CH 3-thiophene-4-base
242 ?2-CH(CH 3) 2-thiophene-4-base
243 ?2-C(CH 3) 3-thiophene-4-base
244 2-cyclopropyl thiophene-4-base
Sequence number ?A a
245 ?2-C 6H 5-thiophene-4-base
246 ?2-(2-CH 3-C 6H 4) thiophene-4-base
247 ?2-(3-CH 3-C 6H 4) thiophene-4-base
248 ?2-(4-CH 3-C 6H 4) thiophene-4-base
249 ?2-(3-OCH 3-C 6H 4) thiophene-4-base
250 ?2-(4-OCH 3-C 6H 4) thiophene-4-base
251 ?2-(4-NO 2-C 6H 4) thiophene-4-base
252 ?2-(3-NO 2-C 6H 4) thiophene-4-base
253 ?2-(4-CN-C 6H 4) thiophene-4-base
254 ?2-(3-CN-C 6H 4) thiophene-4-base
255 ?2-(3-CF 3-C 6H 4) thiophene-4-base
256 ?2-(4-CF 3-C 6H 4) thiophene-4-base
257 ?2-(4-C(CH 3) 3-C 6H 4) thiophene-4-base
258 ?2-(4-C 6H 5-C 6H 4) thiophene-4-base
259 ?2-(2-Cl-C 6H 4) thiophene-4-base
260 ?2-(3-Cl-C 6H 4) thiophene-4-base
261 ?2-(4-Cl-C 6H 4) thiophene-4-base
262 ?2-(2-Br-C 6H 4) thiophene-4-base
263 ?2-(3-Br-C 6H 4) thiophene-4-base
264 ?2-(4-Br-C 6H 4) thiophene-4-base
265 ?2-(2-F-C 6H 4) thiophene-4-base
266 ?2-(3-F-C 6H 4) thiophene-4 base
267 ?2-(4-F-C 6H 4) thiophene-4-base
268 ?2-(2，4-Cl 2-C 6H 3) thiophene-4-base
269 ?2-(2，5-Cl 2-C 6H 3) thiophene-4-base
270 ?2-(2，6-Cl 2-C 6H 3) thiophene-4-base
271 ?2-(3，4-Cl 2-C 6H 3) thiophene-4-base
272 ?2-(2，4-F 2-C 6H 3) thiophene-4-base
273 ?2-(2，5-F 2-C 6H 3) thiophene-4-base
274 ?2-(2，6-F 2-C 6H 3) thiophene-4-base
275 ?2-(3，4-F 2-C 6H 3) thiophene-4-base
276 ?2-(2-Cl，5-OCH 3-C 6H 3) thiophene 4-base
277 ?2-(2-Cl，5-CH 3-C 6H 3) thiophene-4-base
278 ?2-(5-Cl，2-OCH 3-C 6H 3) thiophene-4-base
279 ?2-(5-Cl，2-CH 3-C 6H 3) thiophene-4-base
280 ?2-[2，5-(CH 3) 2-C 6H 3] thiophene-4-base
281 ?1-CH 3-pyrazoles-4-base
282 ?1-CH(CH 3) 2-pyrazoles-4-base
283 ?1-C(CH 3) 3-pyrazoles-4-base
284 1-cyclopropyl pyrazoles-4-base
285 ?1-C 6H 5-pyrazoles-4-base
Sequence number ?A a
286 ?1-(2-CH 3-C 6H 4) pyrazoles-4-base
287 ?1-(3-CH 3-C 6H 4) pyrazoles-4-base
288 ?1-(4-CH 3-C 6H 4) pyrazoles-4-base
289 ?1-(3-OCH 3-C 6H 4) pyrazoles-4-base
290 ?1-(4-OCH 3-C 6H 4) pyrazoles-4-base
291 ?1-(4-NO 2-C 6H 4) pyrazoles-4-base
292 ?1-(3-NO 2-C 6H 4) pyrazoles-4-base
293 ?1-(4-CN-C 6H 4) pyrazoles-4-base
294 ?1-(3-CN-C 6H 4) pyrazoles-4-base
295 ?1-(3-CF 3-C 6H 4) pyrazoles-4-base
296 ?1-(4-CF 3-C 6H 4) pyrazoles-4-base
297 ?1-(4-C(CH 3) 3-C 6H 4) pyrazoles-4-base
298 ?1-(4-C 6H 5-C 6H 4) pyrazoles-4-base
299 ?1-(2-Cl-C 6H 4) pyrazoles-4-base
300 ?1-(3-Cl-C 6H 4) pyrazoles-4-base
301 ?1-(4-Cl-C 6H 4) pyrazoles-4-base
302 ?1-(2-Br-C 6H 4) pyrazoles-4-base
303 ?1-(3-Br-C 6H 4) pyrazoles-4-base
304 ?1-(4-Br-C 6H 4) pyrazoles-4-base
305 ?1-(2-F-C 6H 4) pyrazoles-4-base
306 ?1-(3-F-C 6H 4) pyrazoles-4-base
307 ?1-(4-F-C 6H 4) pyrazoles-4-base
308 ?1-(2，4-Cl 2-C 6H 3) pyrazoles-4-base
309 ?1-(2，5-Cl 2-C 6H 3) pyrazoles-4-base
230 ?1-(2，6-Cl 2-C 6H 3) pyrazoles-4-base
311 ?1-(3，4-Cl 2-C 6H 3) pyrazoles-4-base
312 ?1-(2，4-F 2-C 6H 3) pyrazoles-4-base
313 ?1-(2，5-F 2-C 6H 3) pyrazoles-4-base
314 ?1-(2，6-F 2-C 6H 3) pyrazoles-4-base
315 ?1-(3，4-F 2-C 6H 3) pyrazoles-4-base
316 ?1-(2-Cl，5-OCH 3-C 6H 3) pyrazoles-4-base
317 ?1-(2-Cl，5-CH 3-C 6H 3) pyrazoles-4-base
318 ?1-(5-Cl，2-OCH 3-C 6H 3) pyrazoles-4-base
319 ?1-(5-Cl，2-CH 3-C 6H 3) pyrazoles-4-base
320 ?1-[2，5-(CH 3) 2-C 6H 3] pyrazoles-4-base
321 ?1，5-(CH 3) 2-pyrazole-3-yl
322 ?1-CH 3，5-CH(CH 3) 2-pyrazole-3-yl
323 ?1-CH 3，5-C(CH 3) 3-pyrazole-3-yl
324 ?1-CH 3, 5-cyclopropyl pyrazole-3-yl
325 ?1-CH 3，5-C 6H 5-pyrazole-3-yl
326 ?1-CH 3，5-(2-CH 3-C 6H 4) pyrazole-3-yl
Sequence number ?A a
327 ?1-CH 3，5-(3-CH 3-C 6H 4) pyrazole-3-yl
328 ?1-CH 3，5-(4-CH 3-C 6H 4) pyrazole-3-yl
329 ?1-CH 3，5-(3-OCH 3-C 6H 4) pyrazole-3-yl
330 ?1-CH 3，5-(4-OCH 3-C 6H 4) pyrazole-3-yl
331 ?1-CH 3，5-(4-NO 2-C 6H 4) pyrazole-3-yl
332 ?1-CH 3，5-(3-NO 2-C 6H 4) pyrazole-3-yl
333 ?1-CH 3，5-(4-CN-C 6H 4) pyrazole-3-yl
334 ?1-CH 3，5-(3-CN-C 6H 4) pyrazole-3-yl
335 ?1-CH 3，5-(3-CF 3-C 6H 4) pyrazole-3-yl
336 ?1-CH 3，5-(4-CF 3-C 6H 4) pyrazole-3-yl
337 ?1-CH 3，5-(4-C(CH 3) 3-C 6H 4) pyrazole-3-yl
338 ?1-CH 3，5-(4-C 6H 5-C 6H 4) pyrazole-3-yl
339 ?1-CH 3，5-(2-Cl-C 6H 4) pyrazole-3-yl
340 ?1-CH 3，5-(3-Cl-C 6H 4) pyrazole-3-yl
341 ?1-CH 3，5-(4-Cl-C 6H 4) pyrazole-3-yl
342 ?1-CH 3，5-(2-Br-C 6H 4) pyrazole-3-yl
343 ?1-CH 3，5-(3-Br-C 6H 4) pyrazole-3-yl
344 ?1-CH 3，5-(4-Br-C 6H 4) pyrazole-3-yl
345 ?1-CH 3，5-(2-F-C 6H 4) pyrazole-3-yl
346 ?1-CH 3，5-(3-F-C 6H 4) pyrazole-3-yl
347 ?1-CH 3，5-(4-F-C 6H 4) pyrazole-3-yl
348 ?1-CH 3，5-(2，4-Cl 2-C 6H 3) pyrazole-3-yl
349 ?1-CH 3，5-(2，5-Cl 2-C 6H 3) pyrazole-3-yl
350 ?1-CH 3，5-(2，6-Cl 2-C 6H 3) pyrazole-3-yl
351 ?1-CH 3，5-(3，4-Cl 2-C 6H 3) pyrazole-3-yl
352 ?1-CH 3，5-(2，4-F 2-C 6H 3) pyrazole-3-yl
353 ?1-CH 3，5-(2，5-F 2-C 6H 3) pyrazole-3-yl
354 ?1-CH 3，5-(2，6-F 2-C 6H 3) pyrazole-3-yl
355 ?1-CH 3，5-(3，4-F 2-C 6H 3) pyrazole-3-yl
356 ?1-CH 3，5-(2-Cl，5-OCH 3-C 6H 3) pyrazole-3-yl
357 ?1-CH 3，5-(2-Cl，5-CH 3-C 6H 3) pyrazole-3-yl
358 ?1-CH 3，5-(5-Cl，2-OCH 3-C 6H 3) pyrazole-3-yl
359 ?1-CH 3，5-(5-Cl，2-CH 3-C 6H 3) pyrazole-3-yl
360 ?1-CH 3，5-[2，5-(CH 3) 2-C 6H 3] pyrazole-3-yl
361 ?3-CH 3-different azoles-5-base
362 ?3-CH(CH 3) 2-isoxazole-5-bases
363 ?3-C(CH 3) 3-isoxazole-5-bases
364 3-cyclopropyl isoxazole-5-base
365 ?3-C 6H 5-isoxazole-5-bases
366 ?3-(2-CH 3-C 6H 4) isoxazole-5-base
367 ?3-(3-CH 3-C 6H 4) isoxazole-5-base
Sequence number ?A a
368 ?3-(4-CH 3-C 6H 4) isoxazole-5-base
369 ?3-(3-OCH 3-C 6H 4) isoxazole-5-base
370 ?3-(4-OCH 3-C 6H 4) isoxazole-5-base
371 ?3-(4-NO 2-C 6H 4) isoxazole-5-base
372 ?3-(3-NO 2-C 6H 4) isoxazole-5-base
373 ?3-(4-CN-C 6H 4) isoxazole-5-base
374 ?3-(3-CN-C 6H 4) isoxazole-5-base
375 ?3-(3-CF 3-C 6H 4) isoxazole-5-base
376 ?3-(4-CF 3-C 6H 4) isoxazole-5-base
377 ?3-(4-C(CH 3) 3-C 6H 4) isoxazole-5-base
378 ?3-(4-C 6H 5-C 6H 4) isoxazole-5-base
379 ?3-(2-Cl-C 6H 4) isoxazole-5-base
380 ?3-(3-Cl-C 6H 4) isoxazole-5-base
381 ?3-(4-Cl-C 6H 4) isoxazole-5-base
382 ?3-(2-Br-C 6H 4) isoxazole-5-base
383 ?3-(3-Br-C 6H 4) isoxazole-5-base
384 ?3-(4-Br-C 6H 4) isoxazole-5-base
385 ?3-(2-F-C 6H 4) isoxazole-5-base
386 ?3-(3-F-C 6H 4) isoxazole-5-base
387 ?3-(4-F-C 6H 4) isoxazole-5-base
388 ?3-(2，4-Cl 2-C 6H 3) isoxazole-5-base
389 ?3-(2，5-Cl 2-C 6H 3) isoxazole-5-base
390 ?3-(2，6-Cl 2-C 6H 3) isoxazole-5-base
391 ?3-(3，4-Cl 2-C 6H 3) isoxazole-5-base
392 ?3-(2，4-F 2-C 6H 3) isoxazole-5-base
393 ?3-(2，5-F 2-C 6H 3) isoxazole-5-base
394 ?3-(2，6-F 2-C 6H 3) isoxazole-5-base
395 ?3-(3，4-F 2-C 6H 3) isoxazole-5-base
396 ?3-(2-Cl，5-OCH 3-C 6H 3) isoxazole-5-base
397 ?3-(2-Cl，5-CH 3-C 6H 3) isoxazole-5-base
398 ?3-(5-Cl，2-OCH 3-C 6H 3) isoxazole-5-base
399 ?3-(5-Cl，2-CH 3-C 6H 3) isoxazole-5-base
400 ?3-[2，5-(CH 3) 2-C 6H 3The] isoxazole-5-base
401 ?3-CH 3-4-Cl-isoxazole-5-base
402 ?3-CH(CH 3) 2-4-Cl-isoxazole-5-base
403 ?3-C(CH 3) 3-4-Cl-isoxazole-5-base
404 The 3-cyclopropyl-4-Cl-isoxazole-5-base
405 ?3-C 6H 5-4-Cl-isoxazole-5-base
406 ?3-(2-CH 3-C 6H 4)-4-Cl-isoxazole-5-base
?407 ?3-(3-CH 3-C 6H 4)-4-Cl-isoxazole-5-base
408 ?3-(4-CH 3-C 6H 4)-4-Cl-isoxazole-5-base
Sequence number ?A a
409 ?3-(3-OCH 3-C 6H 4)-4-Cl-isoxazole-5-base
410 ?3-(4-OCH 3-C 6H 4)-4-Cl-isoxazole-5-base
411 ?3-(?4-NO 2-C 6H 4)-4-Cl-isoxazole-5-base
412 ?3-(3-NO 2-C 6H 4)-4-Cl-isoxazole-5-base
413 ?3-(4-CN-C 6H 4)-4-Cl-isoxazole-5-base
414 ?3-(3-CN-C 6H 4)-4-Cl-isoxazole-5-base
415 ?3-(3-CF 3-C 6H 4)-4-Cl-isoxazole-5-base
416 ?3-(4-CF 3-C 6H 4)-4-Cl-isoxazole-5-base
417 ?3-(4-C(CH 3) 3-C 6H 4)-4-Cl-isoxazole-5-base
418 ?3-(4-C 6H 5-C 6H 4)-4-Cl-isoxazole-5-base
419 ?3-(2-Cl-C 6H 4)-4-Cl-isoxazole-5-base
420 ?3-(3-Cl-C 6H 4)-4-Cl-isoxazole-5-base
421 ?3-(4-Cl-C 6H 4)-4-Cl-isoxazole-5-base
422 ?3-(2-Br-C 6H 4)-4-Cl-isoxazole-5-base
423 ?3-(3-Br-C 6H 4)-4-Cl-isoxazole-5-base
424 ?3-(4-Br-C 6H 4)-4-Cl-isoxazole-5-base
425 ?3-(2-F-C 6H 4)-4-Cl-isoxazole-5-base
?426 ?3-(3-F-C 6H 4)-4-Cl-isoxazole-5-base
427 ?3-(4-F-C 6H 4)-4-Cl-isoxazole-5-base
428 ?3-(2，4-Cl 2-C 6H 3)-4-Cl-isoxazole-5-base
429 ?3-(2，5-Cl 2-C 6H 3)-4-Cl-isoxazole-5-base
430 ?3-(2，6-Cl 2-C 6H 3)-4-Cl-isoxazole-5-base
431 ?3-(3，4-Cl 2-C 6H 3)-4-Cl-isoxazole-5-base
432 ?3-(2，4-F 2-C 6H 3)-4-Cl-isoxazole-5-base
433 ?3-(2，5-F 2-C 6H 3)-4-Cl-isoxazole-5-base
434 ?3-(2，6-F 2-C 6H 3)-4-Cl-isoxazole-5-base
435 ?3-(3，4-F 2-C 6H 3)-4-Cl-isoxazole-5-base
436 ?3-(2-Cl，5-OCH 3-C 6H 3)-4-Cl-isoxazole-5-base
437 ?3-(2-Cl，5-CH 3-C 6H 3)-4-Cl-isoxazole-5-base
438 ?3-(?5-Cl，2-OCH 3-C 6H 3)-4-Cl-isoxazole-5-base
439 ?3-(5-Cl，2-CH 3-C 6H 3)-4-Cl-isoxazole-5-base
440 ?3-[2，5-(CH 3) 2-C 6H 3]-4-Cl-isoxazole-5-base
441 ?5-CH 3-isoxazole-3-bases
442 ?5-CH(CH 3) 2-different azoles-3-base
443 ?5-C(CH 3) 3-isoxazole-5-bases
444 5-cyclopropyl isoxazole-3-base
445 ?5-C 6H 5-isoxazole-3-bases
446 ?5-(2-CH 3-C 6H 4) isoxazole-3-base
447 ?5-(3-CH 3-C 6H 4) isoxazole-3-base
448 ?5-(4-CH 3-C 6H 4) isoxazole-3-base
449 ?5-(3-OCH 3-C 6H 4) isoxazole-3-base
Sequence number ?A a
450 ?5-(4-OCH 3-C 6H 4) isoxazole-3-base
451 ?5-(4-NO 2-C 6H 4) isoxazole-3-base
452 ?5-(3-NO 2-C 6H 4) isoxazole-3-base
453 ?5-(4-CN-C 6H 4) isoxazole-3-base
454 ?5-(3-CN-C 6H 4) isoxazole-3-base
455 ?5-(3-CF 3-C 6H 4) isoxazole-3-base
?456 ?5-(4-CF 3-C 6H 4) isoxazole-3-base
457 ?5-(4-C(CH 3) 3-C 6H 4) isoxazole-3-base
458 ?5-(4-C 6H 5-C 6H 4) isoxazole-3-base
459 ?5-(2-Cl-C 6H 4) isoxazole-3-base
460 ?5-(3-Cl-C 6H 4) isoxazole-3-base
461 ?5-(4-Cl-C 6H 4) isoxazole-3-base
462 ?5-(2-Br-C 6H 4) isoxazole-3-base
463 ?5-(3-Br-C 6H 4) isoxazole-3-base
464 ?5-(4-Br-C 6H 4) isoxazole-3-base
465 ?5-(2-F-C 6H 4) isoxazole-3-base
466 ?5-(3-F-C 6H 4) isoxazole-3-base
467 ?5-(4-F-C 6H 4) isoxazole-3-base
468 ?5-(2，4-Cl 2-C 6H 3) isoxazole-3-base
469 ?5-(2，5-Cl 2-C 6H 3) isoxazole-3-base
470 ?5-(2?，6-Cl 2-C 6H 3) isoxazole-3-base
471 ?5-(3，4-Cl 2-C 6H 3) isoxazole-3-base
472 ?5-(2，4-F 2-C 6H 3) isoxazole-3-base
473 ?5-(2，5-F 2-C 6H 3) isoxazole-3 base
474 ?5-(2，6-F 2-C 6H 3) isoxazole-3-base
475 ?5-(3，4-F 2-C 6H 3) isoxazole-3-base
476 ?5-(2-Cl，5-OCH 3-C 6H 3) isoxazole-3-base
477 ?5-(2-Cl，5-CH 3-C 6H 3) isoxazole-3-base
478 ?5-(5-Cl 2-OCH 3-C 6H 3) isoxazole-3-base
479 ?5-(5-Cl，2-CH 3-C 6H 3) isoxazole-3-base
480 ?5-[2，5-(CH 3) 2-C 6H 3The] isoxazole-3-base
481 ?3-CH 3-isothiazole-5-base
482 ?3-CH(CH 3) 2-isothiazole-5-base
483 ?3-C(CH 3) 3-isothiazole-5-base
484 3-cyclopropyl isothiazole-5-base
485 ?3-C 6H 5-isothiazole-5-base
486 ?3-(2-CH 3-C 6H 4) isothiazole-5-base
487 ?3-(3-CH 3-C 6H 4) isothiazole-5-base
488 ?3-(4-CH 3-C 6H 4) isothiazole-5-base
489 ?3-(3-OCH 3-C 6H 4) isothiazole-5-base
490 ?3-(4-OCH 3-C 6H 4) isothiazole-5-base
Sequence number ?A a
491 ?3-(4-NO 2-C 6H 4) isothiazole-5-base
492 ?3-(3-NO 2-C 6H 4) isothiazole-5-base
493 ?3-(4-CN-C 6H 4) isothiazole-5-base
494 ?3-(3-CN-C 6H 4) isothiazole-5-base
495 ?3-(3-CF 3-C 6H 4) isothiazole-5-base
496 ?3-(4-CF 3-C 6H 4) isothiazole-5-base
497 ?3-(4-C(CH 3) 3-C 6H 4) isothiazole-5-base
498 ?3-(4-C 6H 5-C 6H 4) isothiazole-5-base
499 ?3-(2-Cl-C 6H 4) isothiazole-5-base
500 ?3-(3-Cl-C 6H 4) isothiazole-5-base
501 ?3-(4-Cl-C 6H 4) isothiazole-5-base
502 ?3-(2-Br-C 6H 4) isothiazole-5-base
503 ?3-(3-Br-C 6H 4) isothiazole-5-base
504 ?3-(4-Br-C 6H 4) isothiazole-5-base
505 ?3-(2-F-C 6H 4) isothiazole-5-base
506 ?3-(3-F-C 6H 4) isothiazole-5-base
507 ?3-(4-F-C 6H 4) isothiazole-5-base
508 ?3-(2，4-Cl 2-C 6H 3) isothiazole-5-base
509 ?3-(2，5-Cl 2-C 6H 3) isothiazole-5-base
510 ?3-(2，6-Cl 2-C 6H 3) isothiazole-5-base
511 ?3-(3，4-Cl 2-C 6H 3) isothiazole-5 base
512 ?3-(2，4-F 2-C 6H 3) isothiazole-5-base
513 ?3-(2，5-F 2-C 6H 3) isothiazole-5-base
514 ?3-(2，6-F 2-C 6H 3) isothiazole-5-base
515 ?3-(3，4-F 2-C 6H 3) isothiazole-5-base
516 ?3-(2-Cl，5-OCH 3-C 6H 3) isothiazole-5-base
517 ?3-(2-Cl，5-CH 3-C 6H 3) isothiazole-5-base
518 ?3-(5-Cl，2-OCH 3-C 6H 3) isothiazole-5-base
519 ?3-(5-Cl，2-CH 3-C 6H 3) isothiazole-5-base
520 ?3-[2，5-(CH 3) 2-C 6H 3] isothiazole-5-base
?521 ?2-CH 3-oxazoles-4-base
522 ?2-CH(CH 3) 2-oxazoles-4-base
523 ?2-C(CH 3) 3-oxazoles-4-base
524 2-Huan Bing Ji oxazole-4-base
525 ?2-C 6H 5-oxazoles-4-base
526 ?2-(2-CH 3-C 6H 4) oxazole-4-base
527 ?2-(3-CH 3-C 6H 4) oxazole-4-base
528 ?2-(4-CH 3-C 6H 4) oxazole-4-base
529 ?2-(3-OCH 3-C 6H 4) oxazole-4-base
530 ?2-(4-OCH 3-C 6H 4) oxazole-4-base
531 ?2-(4-NO 2-C 6H 4) oxazole-4-base
Sequence number ?A a
532 ?2-(3-NO 2-C 6H 4) oxazole-4-base
533 ?2-(4-CN-C 6H 4) oxazole-4-base
534 ?2-(3-CN-C 6H 4) oxazole-4-base
535 ?2-(3-CF 3-C 6H 4) oxazole-4-base
536 ?2-(4-CF 3-C 6H 4) oxazole-4-base
537 ?2-(4-C(CH 3) 3-C 6H 4) oxazole-4-base
538 ?2-(4-C 6H 5-C 6H 4) oxazole-4-base
539 2-(2-Cl-C 6H 4) oxazole-4-base
540 ?2-(3-Cl-C 6H 4) oxazole-4-base
541 ?2-(4-Cl-C 6H 4) oxazole-4-base
542 ?2-(2-Br-C 6H 4) oxazole-4-base
543 ?2-(3-Br-C 6H 4) oxazole-4-base
544 ?2-(4-Br-C 6H 4) oxazole-4-base
545 ?2-(2-F-C 6H 4) oxazole-4-base
546 ?2-(3-F-C 6H 4) oxazole-4-base
547 ?2-(4-F-C 6H 4) oxazole-4-base
548 ?2-(2，4-Cl 2-C 6H 3) oxazole-4-base
549 ?2-(2，5-Cl 2-C 6H 3) oxazole-4-base
550 ?2-(2，6-Cl 2-C 6H 3) oxazole-4-base
551 ?2-(3，4-Cl 2-C 6H 3) oxazole-4-base
552 ?2-(2，4-F 2-C 6H 3) oxazole-4-base
553 ?2-(2，5-F 2-C 6H 3) oxazole-4-base
554 ?2-(2，6-F 2-C 6H 3) oxazole-4-base
555 ?2-(3，4-F 2-C 6H 3) oxazole-4-base
556 ?2-(2-Cl，5-OCH 3-C 6H 3) oxazole-4-base
557 ?2-(2-Cl，5-CH 3-C 6H 3) oxazole-4-base
558 ?2-(5-Cl，2-OCH 3-C 6H 3) oxazole-4-base
559 ?2-(5-Cl，2-CH 3-C 6H 3) oxazole-4-base
560 ?2-[2，5-(CH 3) 2-C 6H 3] oxazole-4-base
561 ?2-CH 3-thiazole-4-base
562 ?2-CH(CH 3) 2-thiazole-4-base
563 ?2-C(CH 3) 3-thiazole-4-base
564 2-cyclopropyl thiazole-4-base
565 ?2-C 6H 5-thiazole-4-base
566 ?2-(2-CH 3-C 6H 4) thiazole-4-base
567 ?2-(3-CH 3-C 6H 4) thiazole-4-base
568 ?2-(4-CH 3-C 6H 4) thiazole-4-base
569 ?2-(3-OCH 3-C 6H 4) thiazole-4-base
570 ?2-(4-OCH 3-C 6H 4) thiazole-4-base
571 ?2-(4-NO 2-C 6H 4) thiazole-4-base
572 ?2-(3-NO 2-C 6H 4) thiazole-4-base
Sequence number ?A a
573 ?2-(4-CN-C 6H 4) thiazole-4-base
574 ?2-(3-CN-C 6H 4) thiazole-4 base
575 ?2-(3-CF 3-C 6H 4) thiazole-4-base
576 ?2-(4-CF 3-C 6H 4) thiazole-4-base
577 ?2-(4-C(CH 3) 3-C 6H 4) thiazole-4-base
578 ?2-(4-C 6H 5-C 6H 4) thiazole-4 base
579 ?2-(2-Cl-C 6H 4) thiazole-4-base
580 ?2-(3-Cl-C 6H 4) thiazole-4-base
581 ?2-(4-Cl-C 6H 4) thiazole-4-base
582 ?2-(2-Br-C 6H 4) thiazole-4-base
583 ?2-(3-Br-C 6H 4) thiazole-4-base
584 ?2-(4-Br-C 6H 4) thiazole-4-base
585 ?2-(2-F-C 6H 4) thiazole-4-base
586 ?2-(3-F-C 6H 4) thiazole-4-base
587 ?2-(4-F-C 6H 4) thiazole-4-base
588 ?2-(2，4-Cl 2-C 6H 3) thiazole-4-base
589 ?2-(2，5-Cl 2-C 6H 3) thiazole-4-base
590 ?2-(2，6-Cl 2-C 6H 3) thiazole-4-base
591 ?2-(3，4-Cl 2-C 6H 3) thiazole-4-base
592 ?2-(2，4-F 2-C 6H 3) thiazole-4-base
593 ?2-(2，5-F 2-C 6H 3) thiazole-4-base
594 ?2-(2，6-F 2-C 6H 3) thiazole-4-base
595 ?2-(3，4-F 2-C 6H 3) thiazole-4-base
596 ?2-(2-Cl，5-OCH 3-C 6H 3) thiazole-4-base
597 ?2-(2-Cl，5-CH 3-C 6H 3) thiazole-4-base
598 ?2-(5-Cl，2-OCH 3-C 6H 3) thiazole-4-base
599 ?2-(5-Cl，2-CH 3-C 6H 3) thiazole-4-base
600 ?2-[2，5-(CH 3) 2-C 6H 3] thiazole-4-base
601 ?1，3-(CH 3) 2-1,2,4-triazole-5-base
602 ?1-CH 3，3-CH(CH 3) 2-1,2,4-triazole-5-base
603 ?1-CH 3，3-C(CH 3) 3-1,2,4-triazole-5-base
604 ?1-CH 3, 3-cyclopropyl-1,2,4-triazole-5-base
605 ?1-CH 3，3-C 6H 5-1,2,4-triazole-5-base
606 ?1-CH 3，3-(2-CH 3-C 6H 4)-1,2,4-triazole-5-base
607 ?1-CH 3，3-(3-CH 3-C 6H 4)-1,2,4-triazole-5-base
608 ?1-CH 3，3-(4-CH 3-C 6H 4)-1,2,4-triazole-5-base
609 ?1-CH 3，3-(3-OCH 3-C 6H 4)-1,2,4-triazole-5-base
610 ?1-CH 3，3-(4-OCH 3-C 6H 4)-1,24-triazole-5-base
611 ?1-CH 3，3-(4-NO 2-C 6H 4)-1,2,4-triazole-5-base
612 ?1-CH 3，3-(3-NO 2-C 6H 4)-1,2,4-triazole-5-base
613 ?1-CH 3，3-(4-CN-C 6H 4)-1,2,4-triazole-5-base
Sequence number ?A a
614 ?1-CH 3，3-(3-CN-C 6H 4)-1,2,4-triazole-5-base
615 ?1-CH 3，3-(3-CF 3-C 6H 4)-1,2,4-triazole-5-base
616 ?1-CH 3，3-(4-CF 3-C 6H 4)-1,2,4-triazole-5-base
617 ?1-CH 3，3-(4-C(CH 3) 3-C 6H 4)-1,2,4-triazole-5-base
618 ?1-CH 3，3-(4-C 6H 5-C 6H 4)-1,2,4-triazole-5-base
619 ?1-CH 3，3-(2-Cl-C 6H 4)-1,2,4-triazole-5-base
620 ?1-CH 3，3-(3-Cl-C 6H 4)-1,2,4-triazole-5-base
621 ?1-CH 3，3-(4-Cl-C 6H 4)-1,2,4-triazole-5-base
622 ?1-CH 3，3-(2-Br-C 6H 4)-1,2,4-triazole-5-base
623 ?1-CH 3，3-(3-Br-C 6H 4)-1,2,4-triazole-5-base
624 ?1-CH 3，3-(4-Br-C 6H 4)-1,2,4-triazole-5-base
625 ?1-CH 3，3-(2-F-C 6H 4)-1,2,4-triazole-5-base
626 ?1-CH 3，3-(3-F-C 6H 4)-1,2,4-triazole-5-base
627 ?1-CH 3，3-(4-F-C 6H 4)-1,2,4-triazole-5-base
628 ?1-CH 3，3-(2，4-Cl 2-C 6H 3)-1,2,4-triazole-5-base
629 ?1-CH 3，3-(2，5-Cl 2-C 6H 3)-1,2,4-triazole-5-base
630 ?1-CH 3，3-(2，6-Cl 2-C 6H 3)-1,2,4-triazole-5-base
631 ?1-CH 3，3-(3，4-Cl 2-C 6H 3)-1,2,4-triazole-5-base
632 ?1-CH 3，3-(2，4-F 2-C 6H 3)-1,2,4-triazole-5-base
633 ?1-CH 3，3-(2，5-F 2-C 6H 3)-1,2,4-triazole-5-base
634 ?1-CH 3，3-(2，6-F 2-C 6H 3)-1,2,4-triazole-5-base
635 ?1-CH 3，3-(3，4-F 2-C 6H 3)-1,2,4-triazole-5-base
636 ?1-CH 3，3-(2-Cl，5-OCH 3-C 6H 3)-1,2,4-triazole-5-base
637 ?1-CH 3，3-(2-Cl，5-CH 3-C 6H 3)-1,2,4-triazole-5-base
638 ?1-CH 3，3-(5-Cl，2-OCH 3-C 6H 3)-1,2,4-triazole-5-base
639 ?1-CH 3，3-(5-Cl，2-CH 3-C 6H 3)-1,2,4-triazole-5-base
640 ?1-CH 3，3-[2，5-(CH 3) 2-C 6H 3]-1,2,4-triazole-5-base
641 ?5-CH 3-1,3,4-oxadiazole-2-base
642 ?5-CH(CH 3) 2-1,3,4-oxadiazole-2-base
643 ?5-C(CH 3) 3-1,3,4-oxadiazole-2-base
644 5-cyclopropyl-1,3,4-oxadiazole-2-base
645 ?5-C 6H 5-1,3,4-oxadiazole-2-base
646 ?5-(2-CH 3-C 6H 4)-1,3,4-oxadiazole-2-base
647 ?5-(3-CH 3-C 6H 4)-1,3,4-oxadiazole-2-base
648 ?5-(4-CH 3-C 6H 4)-1,3,4-oxadiazole-2-base
649 ?5-(3-OCH 3-C 6H 4)-1,3,4-oxadiazole-2-base
650 ?5-(4-OCH 3-C 6H 4)-1,3,4-oxadiazole-2-base
651 ?5-(4-NO 2-C 6H 4)-1,3,4-oxadiazole-2-base
652 ?5-(3-NO 2-C 6H 4)-1,3,4-oxadiazole-2-base
653 ?5-(4-CN-C 6H 4)-1,3,4-oxadiazole-2-base
654 ?5-(3-CN-C 6H 4)-1,3,4-oxadiazole-2-base
Sequence number ?A a
655 ?5-(3-CF 3-C 6H 4)-1,3,4-oxadiazole-2-base
656 ?5-(4-CF 3-C 6H 4)-1,3,4-oxadiazole-2-base
657 ?5-(4-C(CH 3) 3-C 6H 4)-1,3,4-oxadiazole-2-base
658 ?5-(4-C 6H 5-C 6H 4)-1,3,4-oxadiazole-2-base
659 ?5-(2-Cl-C 6H 4)-1,3,4-oxadiazole-2-base
660 ?5-(3-Cl-C 6H 4)-1,3,4-oxadiazole-2-base
661 ?5-(4-Cl-C 6H 4)-1,3,4-oxadiazole-2-base
662 ?5-(2-Br-C 6H 4)-1,3,4-oxadiazole-2-base
663 ?5-(3-Br-C 6H 4)-1,3,4-oxadiazole-2-base
664 ?5-(4-Br-C 6H 4)-1,3,4-oxadiazole-2-base
665 ?5-(2-F-C 6H 4)-1,3,4-oxadiazole-2-base
666 ?5-(3-F-C 6H 4)-1,3,4-oxadiazole-2-base
667 ?5-(4-F-C 6H 4)-1,3,4-oxadiazole-2-base
668 ?5-(2，4-Cl 2-C 6H 3)-1,3,4-oxadiazole-2-base
669 ?5-(2，5-Cl 2-C 6H 3)-1,3,4-oxadiazole-2-base
670 ?5-(2，6-Cl 2-C 6H 3)-1,3,4-oxadiazole-2-base
671 ?5-(3，4-Cl 2-C 6H 3)-1,3,4-oxadiazole-2-base
672 ?5-(2，4-F 2-C 6H 3)-1,3,4-oxadiazole-2-base
673 ?5-(2，5-F 2-C 6H 3)-1,3,4-oxadiazole-2-base
674 ?5-(2，6-F 2-C 6H 3)-1,3,4-oxadiazole-2-base
675 ?5-(3，4-F 2-C 6H 3)-1,3,4-oxadiazole-2-base
676 ?5-(2-Cl，5-OCH 3-C 6H 3)-1,3,4-oxadiazole-2-base
677 ?5-(2-Cl，5-CH 3-C 6H 3)-1,3,4-oxadiazole-2-base
678 ?5-(5-Cl，2-OCH 3-C 6H 3)-1,3,4-oxadiazole-2-base
679 ?5-(5-Cl，2-CH 3-C 6H 3)-1,3,4-oxadiazole-2-base
680 ?5-[2，5-(CH 3) 2-C 6H 3]-1,3,4-oxadiazole-2-base
681 ?5-CH 3-1,2,4-oxadiazole-3-base
682 ?5-CH(CH 3) 2-1,2,4-oxadiazole-3-base
683 ?5-C(CH 3) 3-1,2,4-oxadiazole-3-base
684 5-cyclopropyl-1,2,4-oxadiazole-3-base
685 ?5-C 6H 5-1,2,4-oxadiazole-3-base
686 ?5-(2-CH 3-C 6H 4)-1,2,4-oxadiazole-3-base
687 ?5-(3-CH 3-C 6H 4)-1,2,4-oxadiazole-3-base
688 ?5-(4-CH 3-C 6H 4)-1,2,4-oxadiazole-3-base
689 ?5-(3-OCH 3-C 6H 4)-1,2,4-oxadiazole-3-base
690 ?5-(4-OCH 3-C 6H 4)-1,2,4-oxadiazole-3-base
691 ?5-(4-NO 2-C 6H 4)-1,2,4-oxadiazole-3-base
692 ?5-(3-NO 2-C 6H 4)-1,2,4-oxadiazole-3-base
693 ?5-(4-CN-C 6H 4)-1,2,4-oxadiazole-3-base
694 ?5-(3-CN-C 6H 4)-1,2,4-oxadiazole-3-base
695 ?5-(3-CF 3-C 6H 4)-1,2,4-oxadiazole-3-base
Sequence number ?A a
696 ?5-(4-CF 3-C 6H 4)-1,2,4-oxadiazole 3-base
697 ?5-(4-C(CH 3) 3-C 6H 4)-1,2,4-oxadiazole-3-base
698 ?5-(4-C 6H 5-C 6H 4)-1,2,4-oxadiazole-3-base
699 ?5-(2-Cl-C 6H 4)-1,2,4-oxadiazole-3-base
700 ?5-(3-Cl-C 6H 4)-1,2,4-oxadiazole-3-base
701 ?5-(4-Cl-C 6H 4)-1,2,4-oxadiazole-3-base
702 ?5-(2-Br-C 6H 4)-1,2,4-oxadiazole-3-base
703 ?5-(3-Br-C 6H 4)-1,2,4-oxadiazole-3-base
704 ?5-(4-Br-C 6H 4)-1,2,4-oxadiazole-3-base
705 ?5-(2-F-C 6H 4)-1,2,4-oxadiazole-3-base
706 ?5-(3-F-C 6H 4)-1,2,4-oxadiazole-3-base
707 ?5-(4-F-C 6H 4)-1,2,4-oxadiazole-3-base
708 ?5-(2，4-Cl 2-C 6H 3)-1,2,4-oxadiazole-3-base
709 ?5-(2，5-Cl 2-C 6H 3)-1,2,4-oxadiazole-3-base
710 ?5-(2，6-Cl 2-C 6H 3)-1,2,4-oxadiazole-3-base
711 ?5-(3，4-Cl 2-C 6H 3)-1,2,4-oxadiazole-3-base
712 ?5-(2，4-F 2-C 6H 3)-1,2,4-oxadiazole-3-base
713 ?5-(2，5-F 2-C 6H 3)-1,2,4-oxadiazole-3-base
714 ?5-(2，6-F 2-C 6H 3)-1,2,4-oxadiazole-3-base
715 ?5-(3，4-F 2-C 6H 3)-1,2,4-oxadiazole-3-base
716 ?5-(2-Cl，5-OCH 3-C 6H 3)-1,2,4-oxadiazole-3-base
717 ?5-(2-Cl，5-CH 3-C 6H 3)-1,2,4-oxadiazole-3-base
718 ?5-(5-Cl，2-OCH 3-C 6H 3)-1,2,4-oxadiazole-3-base
719 ?5-(5-Cl，2-CH 3-C 6H 3)-1,2,4-oxadiazole-3-base
720 ?5-[?2，5-(CH 3) 2-C 6H 3]-1,2,4-oxadiazole-3-base
721 ?3-CH 3-1,2,4-oxadiazole-5-base
722 ?3-CH(CH 3) 2-1,2,4-oxadiazole-5-base
723 ?3-C(CH 3) 3-1,2,4-oxadiazole-5-base
724 3-cyclopropyl-1,2,4-oxadiazole-5-base
725 ?3-C 6H 5-1,2,4-oxadiazole-5-base
726 ?3-(2-CH 3-C 6H 4)-1,2,4-oxadiazole-5-base
727 ?3-(3-CH 3-C 6H 4)-1,2,4-diazole-5-base
728 ?3-(4-CH 3-C 6H 4)-1,2,4-oxadiazole-5-base
729 ?3-(3-OCH 3-C 6H 4)-1,2,4-oxadiazole-5-base
730 ?3-(4-OCH 3-C 6H 4)-1,2,4-oxadiazole-5-base
731 ?3-(4-NO 2-C 6H 4)-1,2,4-oxadiazole-5-base
732 ?3-(3-NO 2-C 6H 4)-1,2,4-diazole-5-base
733 ?3-(4-CN-C 6H 4)-1,2,4-oxadiazole-5-base
734 ?3-(?3-CN-C 6H 4)-1,2,4-oxadiazole-5-base
735 ?3-(3-CF 3-C 6H 4)-1,2,4-oxadiazole-5-base
736 ?3-(4-CF 3-C 6H 4)-1,2,4-oxadiazole-5-base
Sequence number ?A a
737 ?3-(4-C(CH 3) 3-C 6H 4)-1,2,4-oxadiazole-5-base
738 ?3-(4-C 6H 5-C 6H 4)-1,2,4-oxadiazole-5-base
739 ?3-(2-Cl-C 6H 4)-1,2,4-oxadiazole-5-base
740 ?3-(3-Cl-C 6H 4)-1,2,4-oxadiazole-5-base
741 ?3-(4-Cl-C 6H 4)-1,2,4-oxadiazole-5-base
742 ?3-(2-Br-C 6H 4)-1,2,4-oxadiazole-5-base
743 ?3-(3-Br-C 6H 4)-1,2,4-oxadiazole-5-base
744 ?3-(4-Br-C 6H 4)-1,2,4-oxadiazole-5-base
745 ?3-(2-F-C 6H 4)-1,2,4-oxadiazole-5-base
746 ?3-(3-F-C 6H 4)-1,2,4-oxadiazole-5-base
747 ?3-(4-F-C 6H 4)-1,2,4-oxadiazole-5-base
748 ?3-(2，4-Cl 2-C 6H 3)-1,2,4-oxadiazole-5-base
749 ?3-(2，5-Cl 2-C 6H 3)-1,2,4-oxadiazole-5-base
750 ?3-(2，6-Cl 2-C 6H 3)-1,2,4-oxadiazole-5-base
751 ?3-(3，4-Cl 2-C 6H 3)-1,2,4-oxadiazole-5-base
752 ?3-(2，4-F 2-C 6H 3)-1,2,4-oxadiazole-5-base
753 ?3-(2，5-F 2-C 6H 3)-1,2,4-oxadiazole-5-base
754 ?3-(2，6-F 2-C 6H 3)-1,2,4-oxadiazole-5-base
755 ?3-(3，4-F 2-C 6H 3)-1,2,4-oxadiazole-5-base
756 ?3-(2-Cl，5-OCH 3＝C 6H 3)-1,2,4-oxadiazole-5-base
757 ?3-(2-Cl，5-CH 3-C 6H 3)-1,2,4-oxadiazole-5-base
758 ?3-(5-Cl，2-OCH 3-C 6H 3)-1,2,4-oxadiazole-5-base
759 ?3-(5-Cl，2-CH 3-C 6H 3)-1,2,4-oxadiazole-5-base
760 ?3-[2，5-(CH 3) 2-C 6H 3]-1,2,4-oxadiazole-5-base
761 ?5-CH 3-1,2,4-thiadiazoles-3-base
762 ?5-CH(CH 3) 2-1,2,4-thiadiazoles-3-base
763 ?5-C(CH 3) 3-1,2,4-thiadiazoles-3-base
764 5-cyclopropyl-1,2,4-thiadiazoles-3-base
765 ?5-C 6H 5-1,2,4-thiadiazoles-3-base
766 ?5-(2-CH 3-C 6H 4)-1,2,4-thiadiazoles-3-base
767 ?5-(3-CH 3-C 6H 4)-1,2,4-thiadiazoles-3-base
768 ?5-(4-CH 3-C 6H 4)-1,2,4-thiadiazoles-3-base
777 ?5-(3-OCH 3-C 6H 4)-1,2,4-thiadiazoles-3-base
770 ?5-(4-OCH 3-C 6H 4)-1,2,4-thiadiazoles-3-base
771 ?5-(4-NO 2-C 6H 4)-1,2,4-thiadiazoles-3-base
772 ?5-(3-NO 2-C 6H 4)-1,2,4-thiadiazoles-3-base
773 ?5-(4-CN-C 6H 4)-1,2,4-thiadiazoles-3-base
774 ?5-(3-CN-C 6H 4)-1,2,4-thiadiazoles-3-base
775 ?5-(3-CF 3-C 6H 4)-1,2,4-thiadiazoles-3-base
776 ?5-(4-CF 3-C 6H 4)-1,2,4-thiadiazoles-3-base
777 ?5-(4-C(CH 3) 3-C 6H 4)-1,2,4-thiadiazoles-3-base
Sequence number ?A a
778 ?5-(4-C 6H 5-C 6H 4)-1,2,4-thiadiazoles-3-base
779 ?5-(2-Cl-C 6H 4)-1,2,4-thiadiazoles-3-base
780 ?5-(3-Cl-C 6H 4)-1,2,4-thiadiazoles-3-base
781 ?5-(4-Cl-C 6H 4)-1,2,4-thiadiazoles-3-base
782 ?5-(2-Br-C 6H 4)-1,2,4-thiadiazoles-3-base
783 ?5-(3-Br-C 6H 4)-1,2,4-thiadiazoles-3-base
784 ?5-(4-Br-C 6H 4)-1,2,4-thiadiazoles-3-base
785 ?5-(2-F-C 6H 4)-1,2,4-thiadiazoles-3-base
786 ?5-(3-F-C 6H 4)-1,2,4-thiadiazoles-3-base
787 ?5-(4-F-C 6H 4)-1,2,4-thiadiazoles-3-base
788 ?5-(2，4-Cl 2-C 6H 3)-1,2,4-thiadiazoles-3-base
789 ?5-(2，5-Cl 2-C 6H 3)-1,2,4-thiadiazoles-3-base
790 ?5-(2，6-Cl 2-C 6H 3)-1,2,4-thiadiazoles-3-base
791 ?5-(3，4-Cl 2-C 6H 3)-1,2,4-thiadiazoles-3-base
792 ?5-(2，4-F 2-C 6H 3)-1,2,4-thiadiazoles-3-base
793 ?5-(2，5-F 2-C 6H 3)-1,2,4-thiadiazoles-3-base
794 ?5-(2，6-F 2-C 6H 3)-1,2,4-thiadiazoles--3-base
795 ?5-(3，4-F 2-C 6H 3)-1,2,4-thiadiazoles-3-base
796 ?5-(2-Cl，5-OCH 3-C 6H 3)-1,2,4-thiadiazoles-3-base
797 ?5-(2-Cl，5-CH 3-C 6H 3)-1,2,4-thiadiazoles--3-base
798 ?5-(5-Cl，2-OCH 3-C 6H 3)-1,2,4-thiadiazoles-3-base
799 ?5-(5-Cl，2-CH 3-C 6H 3)-1,2,4-thiadiazoles-3-base
800 ?5-[2，5-(CH 3) 2-C 6H 3]-1,2,4-thiadiazoles-3-base
801 ?5-CH 3-1,3,4-thiadiazoles-2-base
802 ?5-CH(CH 3) 2-1,3,4-thiadiazoles-2-base
803 ?5-C(CH 3) 3-1,3,4-thiadiazoles-2-base
804 5-cyclopropyl-1,3,4-thiadiazoles-2-base
805 ?5-C 6H 5-1,3,4-thiadiazoles-2-base
806 ?5-(2-CH 3-C 6H 4)-1,3,4-thiadiazoles-2-base
807 ?5-(3-CH 3-C 6H 4)-1,3,4-thiadiazoles-2-base
808 ?5-(4-CH 3-C 6H 4)-1,3,4-thiadiazoles-2-base
809 ?5-(3-OCH 3-C 6H 4)-1,3,4-thiadiazoles-2-base
810 ?5-(4-OCH 3-C 6H 4)-1,3,4-thiadiazoles-2-base
811 ?5-(4-NO 2-C 6H 4)-1,3,4-thiadiazoles-2-base
812 ?5-(3-NO 2-C 6H 4)-1,3,4-thiadiazoles-3-base
813 ?5-(4-CN-C 6H 4)-1,3,4-thiadiazoles-3-base
814 ?5-(3-CN-C 6H 4)-1,3,4-thiadiazoles-2-base
815 ?5-(3-CF 3-C 6H 4)-1,3,4-thiadiazoles-2-base
816 ?5-(4-CF 3-C 6H 4)-1,3,4-thiadiazoles-2-base
817 ?5-(4-C(CH 3) 3-C 6H 4)-1,3,4-thiadiazoles-2-base
818 ?5-(4-C 6H 5-C 6H 4)-1,3,4-thiadiazoles-2-base
Sequence number ?A a
819 ?5-(2-Cl-C 6H 4)-1,3,4-thiadiazoles-2-base
820 ?5-(3-Cl-C 6H 4)-1,3,4-thiadiazoles-2-base
821 ?5-(4-Cl-C 6H 4)-1,3,4-thiadiazoles-2-base
822 ?5-(2-Br-C 6H 4)-1,3,4-thiadiazoles-2-base
823 ?5-(3-Br-C 6H 4)-1,3,4-thiadiazoles-2-base
824 ?5-(4-Br-C 6H 4)-1,3,4-thiadiazoles-2-base
825 ?5-(2-F-C 6H 4)-1,3,4-thiadiazoles-2-base
826 ?5-(3-F-C 6H 4)-1,3,4-thiadiazoles-2-base
827 ?5-(4-F-C 6H 4)-1,3,4-thiadiazoles-2-base
828 ?5-(2，4-Cl 2-C 6H 3)-1,3,4-thiadiazoles-2-base
829 ?5-(2，5-Cl 2-C 6H 3)-1,3,4-thiadiazoles-2-base
830 ?5-(2，6-Cl 2-C 6H 3)-1,3,4-thiadiazoles-2-base
831 ?5-(3，4-Cl 2-C 6H 3)-1,3,4-thiadiazoles-2-base
832 ?5-(2，4-F 2-C 6H 3)-1,3,4-thiadiazoles-2-base
833 ?5-(2，5-F 2-C 6H 3)-1,3,4-thiadiazoles-2-base
834 ?5-(2，6-F 2-C 6H 3)-1,3,4-thiadiazoles-2-base
835 ?5-(3，4-F 2-C 6H 3)-1,3,4-thiadiazoles-2-base
836 ?5-(2-Cl，5-OCH 3-C 6H 3)-1,3,4-thiadiazoles-2-base
837 ?5-(2-Cl，5-CH 3-C 6H 3)-1,3,4-thiadiazoles-2-base
838 ?5-(5-Cl，2-OCH 3-C 6H 3)-1,3,4-thiadiazoles-2-base
839 ?5-(5-Cl，2-CH 3-C 6H 3)-1,3,4-thiadiazoles-2-base
840 ?5-[2，5-(CH 3) 2-C 6H 3]-1,3,4-thiadiazoles-2-base
841 1，3-(CH 3) 2-pyrazoles-4-base
842 ?3-CH 3，1-CH(CH 3) 2-pyrazoles-4-base
843 ?3-CH 3，1-C(CH 3) 3-pyrazoles-4-base
844 ?3-CH 3, 1-cyclopropyl-pyrazoles-4-base
845 ?3-CH 3，1-C 6H 5-pyrazoles-4-base
846 ?3-CH 3，1-(2-CH 3-C 6H 4) pyrazoles-4-base
847 ?3-CH 3，1-(3-CH 3-C 6H 4) pyrazoles-4-base
848 ?3-CH 3，1-(4-CH 3-C 6H 4) pyrazoles-4-base
849 ?3-CH 3，1-(3-OCH 3-C 6H 4) pyrazoles-4-base
850 ?3-CH 3，1-(4-OCH 3-C 6H 4) pyrazoles-4-base
851 ?3-CH 3，1-(4-NO 2-C 6H 4) pyrazoles-4-base
852 ?3-CH 3，1-(3-NO 2-C 6H 4) pyrazoles-4-base
853 ?3-CH 3，1-(4-CN-C 6H 4) pyrazoles-4-base
854 ?3-CH 3，1-(3-CN-C 6H 4) pyrazoles-4-base
855 ?3-CH 3，1-(3-CF 3-C 6H 4) pyrazoles-4-base
856 ?3-CH 3，1-(4-CF 3-C 6H 4) pyrazoles-4-base
857 ?3-CH 3，1-(4-C(CH 3) 3-C 6H 4) pyrazoles-4-base
858 ?3-CH 3，1-(4-C 6H 5-C 6H 4) pyrazoles-4-base
859 ?3-CH 3，1-(2-Cl-C 6H 4) pyrazoles-4-base
Sequence number ?A a
860 ?3-CH 3，1-(3-Cl-C 6H 4) pyrazoles-4-base
861 ?3-CH 3，1-(4-Cl-C 6H 4) pyrazoles-4-base
?862 ?3-CH 3，1-(2-Br-C 6H 4) pyrazoles-4-base
863 ?3-CH 3，1-(3-Br-C 6H 4) pyrazoles-4-base
864 ?3-CH 3，1-(4-Br-C 6H 4) pyrazoles-4-base
865 ?3-CH 3，1-(2-F-C 6H 4) pyrazoles-4-base
866 ?3-CH 3，1-(3-F-C 6H 4) pyrazoles-4-base
867 ?3-CH 3，1-(4-F-C 6H 4) pyrazoles-4-base
868 ?3-CH 3，1-(2，4-Cl 2-C 6H 3) pyrazoles-4-base
869 ?3-CH 3，1-(2，5-Cl 2-C 6H 3) pyrazoles-4-base
870 ?3-CH 3，1-(2，6-Cl 2-C 6H 3) pyrazoles-4-base
871 ?3-CH 3，1-(3，4-Cl 2-C 6H 3) pyrazoles-4-base
872 ?3-CH 3，1-(2，4-F 2-C 6H 3) pyrazoles-4-base
873 ?3-CH 3，1-(2，5-F 2-C 6H 3) pyrazoles-4-base
874 ?3-CH 3，1-(2，6-F 2-C 6H 3) pyrazoles-4-base
875 ?3-CH 3，1-(3，4-F 2-C 6H 3) pyrazoles-4-base
876 ?3-CH 3，1-(2-Cl，5-OCH 3-C 6H 3) pyrazoles-4-base
877 ?3-CH 3，1-(2-Cl，5-CH 3-C 6H 3)] pyrazoles-4-base
878 ?3-CH 3，1-(5-Cl，2-OCH 3-C 6H 3) pyrazoles-4-base
879 ?3-CH 3，1-(5-Cl，2-CH 3-C 6H 3) pyrazoles-4-base
880 ?3-CH 3，1-[2，5-(CH 3) 2-C 6H 3] pyrazoles-4-base
881 ?3，5-(CH 3) 2，1-C 6H 5-pyrazoles-4-base
882 ?3，5-(CH 3) 2，1-(2-CH 3-C 6H 4) pyrazoles-4-base
883 ?3，5-(CH 3) 2，1-(3-CH 3-C 6H 4) pyrazoles-4-base
884 ?3，5-(CH 3) 2，1-(4-CH 3-C 6H 4) pyrazoles-4-base
885 ?3，5-(CH 3) 2，1-(3-OCH 3-C 6H 4) pyrazoles-4-base
886 ?3，5-(CH 3) 2，1-(4-OCH 3-C 6H 4) pyrazoles-4-base
887 ?3，5-(CH 3) 2，1-(4-NO 2-C 6H 4) pyrazoles-4-base
888 ?3，5-(CH 3) 2，1-(3-NO 2-C 6H 4) pyrazoles-4-base
889 ?3，5-(CH 3) 2，1-(4-CN-C 6H 4) pyrazoles-4-base
890 ?3，5-(CH 3) 2，1-(3-CN-C 6H 4) pyrazoles-4-base
891 ?3，5-(CH 3) 2，1-(3-CF 3-C 6H 4) pyrazoles-4-base
892 ?3，5-(CH 3) 2，1-(4-CF 3-C 6H 4) pyrazoles-4-base
893 ?3，5-(CH 3) 2，1-(4-C(CH 3) 3-C 6H 4) pyrazoles-4-base
894 ?3，5-(CH 3) 2，1-(4-C 6H 5-C 6H 4) pyrazoles-4-base
895 ?3，5-(CH 3) 2，1-(2-Cl-C 6H 4) pyrazoles-4-base
896 ?3，5-(CH 3) 2，1-(3-Cl-C 6H 4) pyrazoles-4-base
897 ?3，5-(CH 3) 2，1-(4-Cl-C 6H 4) pyrazoles-4-base
898 ?3，5-(CH 3) 2，1-(2-Br-C 6H 4) pyrazoles-4-base
899 ?3，5-(CH 3) 2，1-(3-Br-C 6H 4) pyrazoles-4-base
900 ?3，5-(CH 3) 2，1-(4-Br-C 6H 4) pyrazoles-4-base
Sequence number ?A a
901 ?3，5-(CH 3) 2，1-(2-F-C 6H 4) pyrazoles-4-base
902 ?3，5-(CH 3) 2，1-(3-F-C 6H 4) pyrazoles-4-base
903 ?3，5-(CH 3) 2，1-(4-F-C 6H 4) pyrazoles-4-base
904 ?3，5-(CH 3) 2，1-(2，4-Cl 2-C 6H 3) pyrazoles-4-base
905 ?3，5-(CH 3) 2，1-(2，5-Cl 2-C 6H 3) pyrazoles-4-base
906 ?3，5-(CH 3) 2，1-(2，6-Cl 2-C 6H 3) pyrazoles-4-base
907 ?3，5-(CH 3) 2，1-(3，4-Cl 2-C 6H 3) pyrazoles-4-base
908 ?3，5-(CH 3) 2，1-(2，4-F 2-C 6H 3) pyrazoles-4-base
909 ?3，5-(CH 3) 2，1-(2，5-F 2-C 6H 3) pyrazoles-4-base
910 ?3，5-(CH 3) 2，1-(2，6-F 2-C 6H 3) pyrazoles-4-base
911 ?3，5-(CH 3) 2，1-(3，4-F 2-C 6H 3) pyrazoles-4-base
912 ?3，5-(CH 3) 2，1-(2-Cl，5-OCH 3-C 6H 3) pyrazoles-4-base
913 ?3，5-(CH 3) 2，1-(2-Cl，5-CH 3-C 6H 3) pyrazoles-4-base
914 ?3，5-(CH 3) 2，1-(5-Cl，2-OCH 3-C 6H 3) pyrazoles-4-base
915 ?3，5-(CH 3) 2，1-(5-Cl，2-CH 3-C 6H 3) pyrazoles-4-base
916 ?3，5-(CH 3) 2，1-[2，5-(CH 3) 2-C 6H 3] pyrazoles-4-base
Table B
Sequence number ?A a Sequence number ?A a
?1 ?H ?30 ?2-Cl-C 6H 4-CH 2
?2 ?CH 3 ?31 ?3-Cl-C 6H 4-CH 2
?3 ?CH 3CH 2 ?32 ?4-Cl-C 6H 4-CH 2
?4 ?CH 3CH 2CH 2 ?33 ?2，5-Cl 2-C 6H 3-CH 2
?5 CH 3CH(CH 3) 34 ?2-CH 3-C 6H 4-CH 2
?6 (CH 3) 3C ?35 ?3-CH 3-C 6H 4-CH 2
?7 ?CH 2＝CH-CH 2 ?36 ?4-CH 3-C 6H 4-CH 2
?8 ?HC≡C-CH 2 ?37 ?2，3-(CH 3) 2-C 6H 3-CH 2
?9 ?CH 3OCH 2CH 2 ?38 ?2，4-(CH 3) 2-C 6H 3-CH 2
?10 Cyclopropyl-CH 2 ?39 ?2，4，6-(CH 3) 3-C 6H 2-CH 2
?11 ?CH 2＝CH-CH 2-CH 2 ?40 ?2，4，6-(CH 3) 3-C 6H 2-CH 2
?12 ?CH 3-CH＝CH-CH 2 ?41 ?2-CF 3-C 6H 4-CH 2
?13 CH 3-(CH 2) 3 ?42 ?3-CF 3-C 6H 4-CH 2
?14 CH 3-(CH 2) 4 ?43 ?4-CF 3-C 6H 4-CH 2[sic]
15 CH 3-(CH 2) 5 ?44 ?2-CF 3-5-CH 3-C 6H 5-CH 2
?16 Cyclohexyl 45 ?2-CH 3-5-CF 3-C 6H 3-CH 2
?17 ?2-CH 3-cyclohexyl 46 ?2-Br-C 6H 4-CH 2
?18 CH 3-CH 2-C(CH 3) 2 ?47 2-(sec.-propyl)-C 6H 4-CH 2
?19 ?CH 3-CH(CH 3)-CH 2 ?48 2-(sec.-propyl)-3-Cl-C 6H 3-CH 2
?20 ?CH 3-CH(CH 3)-CH 2-CH 2 ?49 ?2-CH 3-5-t-C 4-H 9-C 6H 3-CH 2
?21 ?CH 2＝C(CH 3)-CH 2 ?50 ?2-CH 3-5-t-C 4H 9-C 6H 3-CH 2
?22 HC≡C-C(CH 3)＝CH-CH 2 ?51 ?3-CH 3-5-t-C 4H 9-C 6H 3-CH 2
?23 Cl(CH 3)-C＝CH ?52 ?2-Cl-5-t-C 4H 9-C 6H 3-CH 2
?24 CH 2＝C(Cl)-CH 2- 53 ?3-Cl-5-t-C 4H 9-C 6H 3-CH 2
?25 ?ClCH＝CH-CH 2- 54 ?2-OCH 3-C 6H 4-CH 2
?26 ?C 6H 5-CH 2 ?55 ?3-OCH 3-C 6H 4-CH 2
?27 ?2-F-C 6H 4-CH 2 ?56 ?2-CH 3-5-OCH 3-C 6H 3-CH 2
?28 ?3-F-C 6H 4-CH 2 ?57 ?3-CH 3-5-OCH 3-C 6H 3-CH 2
?29 ?4-F-C 6H 4-CH 2 ?58 ?3-Cl-5-OCH 3-C 6H 3-CH 2
Formula I compound according to the present invention is suitable for preventing and treating the animal pest of harmful fungoid and insect, mite and nematoda.They can be as the mycocide and the sterilant of Crop protection and health, preservation material protection and animal doctor aspect.Harmful insect comprises: lepidopteran, for example, adoxophyes moth, black cutworm, the turnip noctuid, cotton leaf ripple noctuid, Anticarsia, apple silver moth, Chinese horse noctuid, Cacoecia murinana, Capua reticulana, spruce bunworm, Chilo partellus, the west choristoneura fumiferana, some mythimna separatas, Cnaphalocrocis medinali(rice leaf roller), Crocidolomia binotalis, the moth-eaten moth of apple, dendrolimus pini, the wild snout moth's larva of melon, southwestern corn borer, the real moth of cotton spot, the Africa sugarcane borer, Eupoecilia ambiguella, grain skin ground tiger, Lee's small kernel-eating insect, oriental fruit months, bollworm, Heliothis virescens, bollworm, Hellula undalis, Hiberniadefoliaria, fall webworms, Hyponomeuta malinellus, the moth-eaten moth of tomato, the Chinese hemlock spruce geometrid moth, beet armyworm, the lira noctuid, Lithocolletis blancardella, Lobesia botrana, loxostege sticticalis, gypsymoth, lymantria monacha, apple leaf miner, maduca sexta, tent caterpillar, lopper worm, rice hair shin noctuid, the kosam seeds geometrid moth, the star-spangled banner gypsymoth, Pyrausta nubilalis (Hubern)., apple brown bortrix, small noctuid, pink bollworm, the potato poison moth, tangerine leaf lyonetid, large white butterfly, the green noctuid of clover, the carnation steinernema, small cabbage moth, the tangerine ermine moth, oil olive ermine moth, Prodenia sunia, Prodeniaornithogalli, the soybean noctuid, two or three pins pine steinernema, Scrobipalpula absoluta, pink rice borer, pilleriana, noctuid is coveted on the meadow, Egyptian lap worm, twill leaf moth, cotton leaf roller, the red tape clearwing moth, Thaumatopoea pityocampa, the green volume of oak moth, cabbage looper, yellow rice borer, Canada's rouleau snout moth's larva, and galleria mellonella waxmoth, gelechiid, rice bean powder snout moth's larva, the curtain casemaking clothes moth; Coleoptera, for example, vertical bar click beetle, dark and gloomy click beetle, wild cotton resembles, pear flower resembles, Apion vorax, Atomaria linearis, the Da Song bark beetle, the big tortoise plastron of beet, beans are chrysomelid, wild cabbage pod weevil, Ceuthorhynchus napi, beet shin flea beetle, the cigarette wireworm, asparagus beetle, the red wing bark beetle of dragon spruce, northern corn root-worm, 12 variegated leaf first, corn bud root is chrysomelid, Mexico's beans first, the tobacco flea beetle, cottonseed ash weevil, the big weevil of pine, Egyptian alfalfa snout beetle, alfalfa weevil, ips typographus, the cigarette scotellaris, cereal leaf beetle, colorado potato bug, the California wireworm, american rice weevil, the corn click beetle, pollen beetle, Melolontha hippocastani, the west melolonthid in May, rice leaf beetles, vine black ear beak resembles, strawberry ear beak resembles, the horseradish daikon leaf beetle, garden chafer, the melolonthid, Phyllotreta chrysocephala, the light sufficient flea beetle of turnip, cabbage flea beetle, Japanese beetle, PsylliQdes napi, oak is deceived bark beetle, pealeaf weevil, and broad bean weevil, pea weevil, Bruchuslentis, grain weevil, lasioderma serricorne, saw-toothed grain beetle, lesser grain borer, rice weevil, red flour beetle, khapra beetle, the Mexico bean weevil; Diptera, for example, the Mexico oriental fruit fly, Mediterranean fruitfly, sorghum gall midge, the melon trypetid, oil olive trypetid, the wild cabbage cecidomyiia, Delia coarctata, Delia radicum, hydrellia griseola, plant fly, Liriomyza sativae, Americal rice leaf miner, hessian fly, Orseolia oryzae, Sweden's wheat stem chloropid fly, the leaf of spinach flowerfly, Phorbia antiqua, the wild cabbage flowerfly, Phorbiacoarctata, cherry fruit fly, the dish trypetid, Tipula oleracea, marsh daddy-longlegs, and Aedes aegypti, aedes vexans, anopheles maculipennis, chrysomyia bezziana, Chrysomya hominivorax, chrysomyia macellaria, the cordylobia anthropophaga, northern house, anthomyia canicularis, Gasterophilus intestinalis, Glossina morsitans, Haematobia irritans, Haplodiplosis equestris, Hypoderma lineata, Luciliacaprina, lucilia sericata, housefly, Muscina stabulans, Oestrus ovis, the gadfly, Simuliumdamnosum; Thysanoptera, for example, cigarette brown thrip, west thrips, wheat thrips, wheat pipe thrips, the real thrips of tangerine, rice thrips, pale brown thrips, cotton thrips; Hymenoptera, for example, cabbage sawfly, tropical leaf cutting ant, leaf cutting ant, Texas leaf cutting ant, sawfly, apple sawfly, Argentine ant, Iridomyrmex purureus, MonomoriumMayr, fiery ant, the infrared ant of flaring up, the infrablack ant of flaring up; Hemiptera, for example, like green stinkbug, hairy chinch bug, tobacco blackspot fleahopper, red cotton bug, in red stinkbug, Eurygaster integriceps, cotton brown stinkbug, leaf beak coried, lygus hesperus, tarnished plant bug, tarnished plant bug, the green stinkbug of yellow shoulder, beet intend lace bug, Solubea insularis, Thyantaperditor; Homoptera, for example, Acyrthosiphon onobrychis, the pea aphid, adelge laricis, California red scale, Aphidula nasturtii, aphis fabae, cotten aphid, apple aphid, the eggplant ditch does not have the net aphid, sweet potato whitefly, Ji short-tail aphid, brevicoryne brassicae, Dalbulus maidis, Dreyfusia nordmannianae, Dreyfusia pieeae, Dysaphis radicola, egg beans Empoasca spp, eriosoma lanigerum, small brown-back rice plant-hopper, grain aphid, potato aphid, rose aphid, broad bean is repaiied the tail aphid, the rose wheat aphid, black peach aphid, cherry knurl aphid, rice green leafhopper, Nilaparvata lugen (brown planthopper), the sugarcane plant hopper, hops wart volume aphid, citrus mealy bug, apple sucker, pear sucker, pear psyllid, pears large bamboo hat with a conical crown and broad brim circle a red-spotted lizard, corn Rhopalosiphum spp, oil lam black helmet kuwana, split aphid between grass, west Indian red Aspidiotus, grain aphid, white backed planthopper, citrus aphid, knot wing aleyrodid, greenhouse whitefly, grape phylloxera; Isoptera, for example, Calotermes flavicollis, Leucotermes flavipes, Macrotermes subhyalinus, blackwing subterranean, Reticulitermes lucifugus, Termes natalensis; Orthoptera, for example, European mole cricket, migratory locusts, two-striped grasshopper, red leg grasshopper, Mexico grasshopper, migrate grasshopper, Luo Ji mountain grasshopper, red wing locust, America locust, Schistocerca peregrina, Stauronotus maroccanus, desert locust and acheta domestica, oriental cockroach, Groton bug, periplaneta americana; Arachnida, for example, the mite class of phytophagy such as tomato leaf thorn skin goitre mite, Aculops pelekassi, apple thorn goitre mite, purplish red short hairs mite, Bryobia praetiosa, carpinus turczaninowii beginning tetranychid, Ban Shi true leaf mite, tangerine goitre mite, meadow unguiculus mite, panonychus ulmi, the tangerine Panonychus citri, citrus rust mite, Polyphagotarsonemus latus Banks, light tarsonemid mite, carmine spider mite, kamisawa tetranychus, Pacific Ocean tetranychid, T.urticae Koch, the tick such as the U.S. spend tick, Amblyomma variegatum, adobe tick, annular ox tick, the ox tick fades, boophilus microplus, dermacentor silvarum, tack glass eye tick, castor bean tick, Ixodes rubicundus, tampan tick, ear stings residual beak beer, rhipicephalus appendiculatus and Rhipicephalus evertsi and animal parasitic mite such as chicken peronium mite, sheep sore mite and itch mite; Nematode, for example, root knot nematode, Meloidogyne hapla for example, the jute root knot nematode, javanese root knot nematode, the capsule nematode, Globodera pallida for example, Globoderarostochiensis, Heterodera avenae, Heterodera glycines, the Shi Shi golden nematode, transport property endoparasitism nematode and half endoparasitism nematode, for example, Heliocotylenchusmulticinctus, Hircshmanniella oryzae, Hoplolaimus spp., the short-tail Tylenchida, Pratylenchus fallax, Pratylenchus penetrans, Pratylenchus vulnus, the similes thorne of being the very image of, Rotylenchus reniformis, Scutellonema bradys, Tylenchulus semipenetrans, stem and leaf nematode, for example, Anguina tritici, rice is held aphelenchoides in vain, Ditylenchus angustus, Ditylenchus dipsaci, viral vector, for example, Longidorua spp., Ke Shi bangs root nematode, Trichodorus viruliferus, Xiphinema index, the Mediterranean Sea sword nematode.
Compound I can with itself form or with the form of its preparation or by the type of service of preparation, for example with directly aqueous spray solutions, pulvis, suspension agent or dispersion liquid, emulsion, oily dispersion liquid, paste, the composition that dusts, the form of spreading fertilizer over the fields composition or granule, by spraying, atomizing, dust, spread fertilizer over the fields or pour use.Administration form depends on the purpose of use; Under each situation, should guarantee that the dispersion of active compound of the present invention is trickle as much as possible and even.
Formula I compound is in some cases for having the mycocide of systemic activity.They can be used as blade face and soil mycocide, and the plant pathogenic fungi of control wide spectrum is particularly to the fungi of Ascomycetes, imperfect fungi, Phycomycetes and Basidiomycetes.
Their many fungies aspect particularly importants on the seed of the various crops of control such as wheat, rye, barley, oat, rice, corn, grass, cotton, big beans, coffee, sugarcane, grape, fruit, ornamental plant and vegetables (for example, cucumber, beans and cucumber) and these crops.
Compound I is particularly suitable for preventing and treating the following plants disease: *Cereal class Powdery Mildew, *The cucumber Powdery Mildew, *Apple mildew, *Uncinula necator, *Cereal class handle rust, *Silk nuclear on cotton and the lawn is sick, *Cereal class and sugarcane smut disease, *Scab of apple, *Cereal class net blotch, *Wheat glume blight, *Strawberry and grape grey mould, *The cercospora brown spot of peanut, *Wheat and barley eye spot, *Rice blast, *Potato and tomato late blight, *Fusarium disease on the various crops and verticillium sp disease, *Downy mildew of garpe, *Alternaric bacteria disease on vegetables and the fruit.
This compounds also can adopt not protecting materials (protection timber), for example prevents and treats paecilomyces varioti.
They can convert conventional formulation such as solution, emulsion, suspension agent, pulvis, dust base, paste and granule to.Administration form depends on specific use; In all cases, must guarantee that their dispersion is trickle as much as possible and even.
These preparations can prepare in a known manner, for example by with active compound solvent and/or carrier, if desired, adopt emulsifying agent and dispersion agent to fill, if use water as thinner, also can make solubility promoter with other organic solvent.
The solubility promoter that is suitable for this purpose mainly is :-solvent such as aromatic substance (for example dimethylbenzene), chloro aromatic substance (for example chlorobenzene), paraffin (example
As petroleum cuts), alcohols (for example methyl alcohol, butanols), ketone (for example pimelinketone), amine (for example
Thanomin, dimethyl formamide) and water;-carrier is as the natural mineral matter (for example kaolin, alumina, talcum, chalk) of grinding and closing of grinding
Metallogenic material (for example silicic acid of high dispersive, silicate);-emulsifying agent such as nonionic and anionic emulsifier (for example polyoxyethylene aliphatic alcohol ether, alkylsulfonate
And arylsulphonate) and-dispersion agent such as lignin sulfite waste lye or methylcellulose gum.
The surfactant that is fit to is an aromatic sulfonic acid (lignosulfonic acid for example, sulfocarbolic acid, naphthene sulfonic acid and dibutyl naphthene sulfonic acid) and the basic metal of lipid acid, alkaline-earth metal and ammonium salt, alkylsulfonate and alkylaryl sulphonate, alkyl-sulphate, lauryl ether sulfate and aliphatic alcohol sulfate, and Sulfated 16-, 17-and the salt of stearyl alcohol and fatty alcohol-ether, sulfonated naphthalene and its derivative and formaldehyde condensation product, the condensation product of naphthalene or naphthene sulfonic acid and phenol and formaldehyde, polyoxyethylene octylphenol ether, the iso-octyl of oxyethyl group alkanisation-, octyl group-or nonyl phenol, alkylphenol or tributyl phenyl polyglycol ether, alkyl aryl polyether alcohol, different three decyl alcohol, the Fatty Alcohol(C12-C14 and C12-C18) ethylene oxide condensate, ethoxylated castor oil, Voranol EP 2001 or polyoxytrimethylene, lauryl alcohol polyglycol ether acetic ester, Isosorbide Dinitrate, lignin sulfite waste lye or methylcellulose gum.
Aqueous administration form can be by adding water, by missible oil, dispersion liquid, paste, wettable powder or water dispersible granule preparation.Preparation is when emulsion, paste or oily dispersion liquid, by adding wetting agent, tackiness agent, dispersion agent or emulsifying agent, material is homogenized in water or is dissolved in oil or the solvent.And, also can prepare by active substance, wetting agent, tackiness agent, dispersion agent or emulsifying agent and possible solvent or the oily enriched material of forming, this enriched material is suitable for dilute with water.
Pulvis, spread fertilizer over the fields and the composition that dusts can be by mixing active substance or grinding and produce with solid carrier.
Granule (for example, coating, dipping or homogeneous particle agent) can prepare by active compound is adhered on the solid carrier.
Solid carrier is that ore soil is as silica gel, silicic acid, silicate, talcum, kaolin, Wingdale, lime, chalk, terra miraculosa, loess, potter's clay, rhombspar, diatomite, calcium sulfate and sal epsom, magnesium oxide, the synthetic materials, the chemical fertilizer that grind are as ammonium sulfate, ammonium phosphate, ammonium nitrate, urea and plant product such as flour, tree bark powder, wood powder and nutshell powder, cellulose powder and other solid carrier.
Activity compound concentration in direct useful formulations can change in wide relatively scope.
Usually, composition contains 0.0001 to 95% active compound by weight.
Contain greater than the preparation of 95% active compound by weight and can successfully be used in the ultra-low volume method (ULV), even may use active compound and need not additive.
When the mycocide, recommend to use by weight 0.01 to 95%, preferred 0.5 to 90% activity component concentration by weight.When the sterilant, preparation contains by weight 0.0001 to 10%, and preferred 0.01 to 1% active compound by weight is fit to.
Active compound is general to adopt 90 to 100%, preferred 95 to 100% purity (according to the NMR spectrum).
These examples of formulations are: the solution of the The compounds of this invention I of weight part and 10 weight part N-methyl-alpha-pyrrolidones I.90, it is fit to use with the form of very little droplet.Solution in the following mixture of The compounds of this invention I of II.20 weight part: the calcium salt of dodecylbenzene sulfonate of 8 to 10 moles of ethylene oxide of the alkylated benzenes of 80 weight parts, 10 weight parts and the affixture of 1 mole of oleic acid N-single ethanol amide, 5 weight parts and 40 moles of ethylene oxide of 5 weight parts and the affixture of 1 mole of castor oil.In this preparation segmentation aproll, obtain dispersion liquid.The solution of the Compound I of III.20 weight part in following mixture: the pimelinketone of 40 weight parts, 30
The isopropylcarbinol of weight part, 7 moles of ethylene oxide of 20 weight parts and adding of 1 mole of isooctylphenol
Become thing and 40 moles of ethylene oxide of 10 weight parts and the affixture of 1 mole of castor oil.With this
In the preparation segmentation aproll, obtain dispersion liquid.The water-dispersion of The compounds of this invention I in following mixture of IV.20 weight part: the ring of 25 weight parts
Ketone, 65 weight part boiling points are 40 of 210 to 280 ℃ mineral oil fraction and 10 weight parts
The affixture of moles of ethylene oxide and 1 mole of castor oil.In this preparation segmentation aproll, obtain to divide
Liquid looses.V.20 the diisobutyl naphthalene-α-sulfonate sodium of the The compounds of this invention I of weight part, 3 weight parts,
The lignin sodium sulfate salt that derives from sulfite waste liquor of 17 weight parts and the granular colloidal silica of 60 weight parts
Ground mixture in sledge mill.In this preparation segmentation aproll, obtain spraying fluid.The kaolinic intimate mixture that the The compounds of this invention I of VI.3 weight part and 97 weight parts are finely divided.
This dusts and contains 3% (weight) active compound by weight.The The compounds of this invention I of VII.30 weight part, the granular colloidal silica of 92 weight parts and 8 weight parts are sprayed
Intimate mixture to the paraffin on the surface of silica gel.This preparation is given active compound with good
Viscosity.The The compounds of this invention I of VIII.40 weight part, the sulfocarbolic acid/urea/formaldehyde condensation of 10 weight parts
The stabilize water dispersion liquid of the water of the silica gel of thing, 2 weight parts and 48 weight parts.It can be further
Dilution.The The compounds of this invention I of IX.20 weight part and the calcium salt of dodecylbenzene sulfonate of 2 weight parts, 8 weight
The sodium salt and 68 weight parts of the Fatty Alcohol(C12-C14 and C12-C18) glycol ether of part, the phenol/urea/formaldehyde condensation products of 2 weight parts
The stable oil dispersant of paraffin sample mineral oil.X. the diisobutyl naphthalene-α-sulfonate sodium of the The compounds of this invention I of 10 weight parts, 4 weight parts,
The lignin sodium sulfate salt that derives from sulfite waste liquor of 20 weight parts, the silica gel and 38 of 38 weight parts
The kaolin of weight part is the ground mixture in sledge mill.This preparation is finely divided in 10.000 weights
In the water of amount part, obtain to contain by weight the spray mixing thing of 0.1% active compound.
Compound I is to make it not to be subjected to seed, plant, material or the soil of fungi infringement to be used by handling harmful fungoid with this compound of mycocidal live vol or being intended to be protected.
Be applied in that material, plant or seed carry out before or after being infected by harmful fungoid.
According to required type of effect, amount of application is 0.02g to 3kg active compound/hectare, preferred 0.1 to 1kg/ hectare.
Handling kind of a period of the day from 11 p.m. to 1 a.m, the general requirement of active compound is 0.001 to 50g, preferred 0.01g to 10g/kg seed.
The active compound amount of application of pest control or harmful fungoid is 0.02 to 10 under outdoor conditions, preferred 0.1 to 2.0kg active compound/hectare.
Compound I, can use separately or with the combination of weedicide or mycocide, also can be mixed together with other crop protection agents, for example mix with growth regulator or with pest control or bacteriocin.Same interested be with chemical fertilizer or with the miscibility that adopts the mineral salt solution of eliminating nutrition and trace element deficiency.
Crop protection agents and chemical fertilizer can add in the present composition with 1: 10 to 10: 1 weight ratio, if suitable even can add (bucket is mixed) before using at once.When mixing with mycocide or sterilant, in many cases, the broadening of fungicidal spectrum.
Following mycocide can be used with the present composition, lists the possibility that they are intended to illustrate combination, but not is intended to limit it:
Sulphur, dithiocarbamate and derivative thereof, as ferric dimethyl dithiocarbamate, ziram, second two support bisdithiocarbamic zinc, second two support bisdithiocarbamic manganese, second two phenylenediamine base bisdithiocarbamic MnZns, curing methyl thiuram, N, ammonium title complex, the N of N-second two support bisdithiocarbamic zinc, N '-the third two support bisdithiocarbamic zinc, N, N '-the third two two (sulfuration carbamyl) disulphide of support; Nitro-derivative, as dinitrobenzene (1-methylheptyl) phenylcrotonic acid ester, the 2-tertiary butyl-4,6-dinitrobenzene-phenyl 3,3-dimethacrylate, the 2-tertiary butyl-4,6-dinitrobenzene-propyloxy phenyl base carbonic ether, the different phthalic ester of di-isopropyl 5-nitro;
The heterocycle material, as 2-heptadecyl-2-tetrahydroglyoxaline acetic ester, 2,4-two chloro-6-(m-chloro aniline base)-s-triazine, O, O-diethyl phthalimido Thiophosphonate, 5-amino-1-β-[two-(dimethylamino)-phosphinyl]-3-phenyl-1,2, the 4-triazole, 2,3-dicyano-1,4-dithio anthrone, 2-sulfo--1,3-two sulphur are (thiolo)-β-[4 also, 5-b] quinoxaline, 1-(butyl formamyl)-methyl 2-benzimidazolecarbamate, the amino benzoglyoxaline of 2-methoxycarbonyl, 2-(furans-(2)-yl) benzoglyoxaline, 2-(thiazolyl-(4)) benzoglyoxaline, N-(1,1,2,2-tetrachloro ethylmercapto group) tetrahydrochysene phthalimide, N-trichloro-methylthio tetrahydrochysene phthalimide, N-trichloro-methylthio phthalimide, N-dichloro fluorine methylthio group-N, N '-dimethyl-N-phenyl sulphamide, 5-oxyethyl group-3-trichloromethyl-1,2, the 3-thiadiazoles, 2-thiocyanomethylthio benzothiazole, 1,4-two chloro-2, the 5-dimethoxy benzene, 4-(2-chloro-phenyl-hydrazono-)-3-methyl-5-isoxazolidinone, 2-sulfo-pyridine 1-oxide compound, oxine or its mantoquita, 2,3-dihydro-5-anilide base-6-methyl isophthalic acid, the 4-oxathiin, 2,3-dihydro-5-anilide base-6-methyl isophthalic acid, 4-oxathiin 4, the 4-dioxide, 2-methyl-5,6-dihydro-4H-pyrans-3-anilide, 2-methyl furan-3-anilide, 2,5-dimethyl furan base-3-anilide, 2,4,5-trimethylammonium furans-3-anilide, N-cyclohexyl-2,5-dimethyl furan-3-anilide, N-cyclohexyl-N-methoxyl group-2,5-dimethyl furan-3-anilide, 2-toluyl aniline, 2-iodobenzene formylaniline, N-formyl-N-morpholine-2,2,2-three aminoethyl acetals, piperidines-1,4-two bases are two, and (1-(2,2,2-three chloroethyls)) methane amide, 1-(3,4 dichlorobenzene amidos)-1-formamido group-2,2, the 2-trichloroethane, 2,6-dimethyl-N-tridecyl morpholine or its salt, 2,6-dimethyl-N-encircles ten dimorpholines or its salt, N-[3-(to tert-butyl-phenyl)-2-methyl-propyl]-suitable-2, the 6-thebaine, N-[3-(to tert-butyl-phenyl)-2-methyl-propyl] piperidines, 1-[2-(2, the 4-dichlorophenyl)-4-ethyl-1,3-two oxa-s penta ring-2-base ethyl]-1H-1,2, the 4-triazole, 1-[2-(2, the 4-dichlorophenyl)-4-n-propyl-1,3-two oxa-s penta ring-2-base ethyl]-1H-1,2, the 4-triazole, N-(n-propyl)-N-(2,4,6-Trichlorophenoxy ethyl)-N '-imidazolyl urea, 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2, the 4-triazol-1-yl)-2-butanone, 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2, the 4-triazol-1-yl) 2-butanols, α-(2-chloro-phenyl-)-α-(4-chloro-phenyl-) 5-rubigan, 5-butyl-2-dimethylamino-4-hydroxyl-6-methylpyrimidine, two (rubigan)-3-piconols, 1, two (3-ethoxycarbonyl-2-thioureido) benzene of 2-, 1, two (3-methoxycarbonyl-2-thioureido) benzene of 2-;
And various mycocides; as the Cyprex acetate; 3-[3-(3; 5-dimethyl-2-oxygen basic ring hexyl)-and the 2-hydroxyethyl] glutaramide; Perchlorobenzene; DL-methyl N-(2; the 6-3,5-dimethylphenyl)-N-2-furans amido propionic ester; DL-N-(2; the 6-3,5-dimethylphenyl)-N-(2 '-methoxyl group ethanoyl) alanine methyl esters; N-(2; the 6-3,5-dimethylphenyl)-N-chloracetyl-D; L-2-amino-butyrolactone; DL-N-(2; the 6-3,5-dimethylphenyl)-N-(phenyl acetyl) alanine methyl esters; 5-methyl-5-vinyl-3-(3; the 5-dichlorophenyl)-2; 4-dioxo-1; the 3-oxazolidine; 3-(3; the 5-dichlorophenyl)-5-methyl-5-methoxymethyl-1; 3-oxazolidine-2; the 4-diketone; 3-(3; the 5-dichlorophenyl)-the 1-isopropyl-carbamoyl hydantoin; N-(3; the 5-dichlorophenyl)-1; 2-dimethylcyclopropane-1; the 2-diformamide; 2-cyano group-N-ethylamino carbonyl-2-methoxyimino ethanamide; 1-[2-(2; the 4-dichlorophenyl) amyl group]-1H-1; 2; the 4-triazole; 2; 4-two fluoro-α-(1H-1; 2,4-triazolyl-1-methyl) diphenyl-carbinol; N-(3-chloro-2,6-dinitrobenzene-4-trifluoromethyl)-5-trifluoromethyl-3-chloro-2-aminopyridine; 1-((two (4-fluorophenyl) methyl-silica-based) methyl)-1H-1; 2,4 triazoles.Synthetic embodiment
The method of oblatio among the synthetic embodiment below adopting is done suitable modification to starting compound, obtains other formula I compound.The compound that obtains is thus listed in down in the tabulation with its physical data.Embodiment 1 α-(3-iodine phenoxy group) Ba Dousuan methyl ester
At 0 to 5 ℃, 11 gram (0.05 mole) 3-iodophenols are added dropwise in 30 milliliters of dimethyl formamide solutions of 3 gram (0.055 mole) KOH.At the 3-bromocrotonic acid methyl esters of same temperature adding 9 grams (0.05 mole), at room temperature continue to stir one hour.Mixture is handled with frozen water, and extracts with methyl tertiary butyl ether, and methyl tertiary butyl ether is through dried over sodium sulfate and vacuum concentration.Residue silica gel chromatography (hexanaphthene/ethylhexoate: 99/1) purifying.Obtain 9.7 grams (theoretical value 61%) oily title compound.
1H-NMR (COCl 3, the δ scale)=1.83 (d, 3H); 3.73 (s, 3H); 6.75 (q, 1H); 6.80-7.40 (m, 4H).Embodiment 2:2-(4 '-chlorodiphenyl base-4 '-Ji oxygen base) but-2-ene acid methyl esters
Sodium bicarbonate, 1.1 gram (0.007 mole) 4-chlorophenylboronic acids and 20 milligram of four [triphenylphosphine] palladium mixture and 30 milliliters of glycol dimethyl ethers in 30 ml waters of 2.2 gram (0.07 mole) α-(3-iodine phenoxy group) methyl crotonates, 1.8 grams (0.021 mole) were refluxed 3 hours.During aftertreatment, use extracted with diethyl ether, ether is through dried over sodium sulfate and vacuum evaporating solvent.
Residue silica gel chromatography (hexanaphthene/ethylhexoate: 98/2) purifying.Obtain 2.2 grams (theoretical value 90%) oily title compound.
1H-NMR (COC 3l 3, the δ scale)=1.82 (d, 3H); 3.8 (s, 3H); 6.73 (q, 1H); 6.82-7.55 (m, 8H).Embodiment 32-[(3 '-acetyl phenyl) methylamino] but-2-ene acid methyl esters
4.7 gram (0.032 mole) 1-(3-methylamino phenyl) ethyl ketones in 100 milliliters of toluene, 100 milligrams of toluenesulphonic acidss, 3.7 gram (0.07 mole) 2-oxy butyrate mixtures of methyl esters heated in water separator 4 hours.The vacuum-evaporation reaction mixture, residue is through silica gel chromatographic column (hexanaphthene/ethylhexoate: 95/5) purifying.Obtain 3.4 grams (theoretical value 69%) oily title compound.(fusing point=73-76 ℃)
1H-NMR (COCl 3, the δ scale)=1.81 (d, 3H); 2.61 (s, 3H); 3.09 (s, 3H); 3.79 (s, 3H); 6.76 (q, 1H); 7.10-7.60 (m, 4H).Embodiment 42-{3-[1-(1-m-toluene ethoxy imino) ethyl] phenyl-N-methylamino-M Cr
1.2 methylamino gram 2-[(3 '-acetyl phenyl)] but-2-ene acid methyl esters, 1-(4-aminomethyl phenyl) ethyl-hydroxyl amino of 0.72 gram (0.005 mole), 2 gram sal epsom and 100 milligrams of Dowex Mixture in 100 milliliters of anhydrous methanols, refluxed 3 hours.
During aftertreatment,, handle residue (hexanaphthene/ethylhexoate: 97/3), provide 1.2 gram (theoretical value 63%) oily title compounds with silica gel chromatography subsequently with reaction soln vacuum-evaporation. 1H-NMR (COCl 3, the δ scale)=1.62 (d, 3H); 1.82 (d, 3H); 2.21 (s, 3H); 2.29 (s, 3H); 3.05 (s, 3H); 3.75 (s, 3H); 5.24 (g, 1H); 6.60-7.25 (m, 8H).
Table
Sequence number R 1U ?R 2 ???V ????X ??Y ???Z ??R 3 ????????????????R 4 Physical data
01 OCH 3 CH 3 O CH CH CH H ?C 6H 5 ? 1H：1.80(d，3H)；3.74(s，3H)； 6.74(g，1H)；6.75-7.40(m，9H)
02 OCH 3 CH 3 O CH CH CH H ?2-Cl-C 6H 4 ? 1H：1.81(d，3H)；6.77(g，1H)； 6.90-7.45?(m，8H)
03 OCH 3 CH 3 O CH CH CH H ?3-Cl-C 6H 4 ? 1H：1.80(d，3H)；3.75(s，3H)； 6.71(g，1H)；6.82-7.55(m，8H)
04 OCH 3 CH 3 O CH CH CH H ?4-Cl-C 6H 4 ? 1H：1.82(d，3H)；3.8(s，3H)； 6.73(g，1H)；6.85-7.50(m，8H)
05 OCH 3 CH 3 O C-CH 3 CH CH H ?C 6H 5 ? 1H：1.81(d，3H)；2.30(s，3H)； 6.60-7.40(m，8H)
06 OCH 3 CH 3 O ?CH CH CH H ?CH＝NOCH 2-(4-Cl-C 6H 4) m.p.：66-68℃
07 OCH 3 CH 3 O ?CH CH CH H CH＝CH-[4-Cl，3-(4-Cl-C 6H 4)-isoxazole-5-base m.p.：141-143℃
08 OCH 3 ?CH 3 O ?CH ?CH CH H CH＝CH-(3-CH 3-C 6H 4) ? 1H：1.80(d，3H)；2.38(s，3H)； 3.75(s，3H)；6.76(g，1H)； 7.00-7.45(m，8H)
09 OCH 3 ?CH 3 O CH ?CH CH ?H ?3，4-Cl 2-C 6H 3 m.p.：83-85℃
10 OCH 3 ?CH 3 O ?CH ?CH CH ?H ?3，5-Cl 2-C 6H 3 ? 1H：1.80(d，3H)；3.72(s，3H)； 6.75(g，1H)；6.85-7.45(m，7H)
11 OCH 3 ?CH 3 O CH CH CH ?H ?3-F-C 6H 4 ? 1H：1.78(d，3H)；3.78(s，3H)； 6.78(s，3H)；6.78(g，1H)； 6.90-7.40(m，8H)
Sequence number ?R 1U R 2 ???V ???X ??Y ??Z ??R 3 ????????????R 4 Physical data
12 ?OCH 3 ?CH 3 O CH CH CH H ?3-CH 3-C 6H 4 1H： 1.80(d，3H)；2.41(s，3H；6.78 (g，1H)；6.90-7.40(m，8H)
13 ?OCH 3 ?CH 3 O CH CH CH H ?C 6H 4-C 6H 5 ?m.p.：109-110℃
14 ?OCH 3 ?CH 3 O CH CH CH H ?4-C(CH 3) 3-C 6H 4 1H：1.35(s，9H)；1.82(d，3H)； 3.70(s，3H)；6.74(g，1H)； 6.90-7.45(m，8H)
15 ?OCH 3 ?CH 3 O CH CH CH H ?4-OCH 3-C 6H 4 1H：1.80(d，3H)；3.72(s，3H)； 3.82(s，3H)；6.75(g，1H)； 6.90-7.50(m，8H)
16 ?OCH 3 ?CH 3 O CH CH CH H ?3-OCH 3-C 6H 4 1H：1.82(d，3H)；3.73(s，3H)； 3.84(s，3H)；6.72(g，1H)； 6.85-7.35(m，8H)
17 ?OCH 3 ?CH 3 O CH CH CH H ?2，3-[OCH 2CH 2O]-C 6H 3 1H：1.83(d，3H)；3.70(s，3H)； 4.30(s，4H)；6.73(g，1H)； 6.80-7.35(m，7H)
18 ?OCH 3 ?CH 3 O CH CH CH H ?3，5-(CF 3) 2-C 6H 3 1H：1.82(d，3H)；3.74(s，3H)； 6.72(g，1H)；6.90-7.30(m，4H)； 7.90(s，1H)；8.00(s，1H)
19 ?OCH 3 ?CH 3 O CH CH CH H ?6-OCH 3-naphthalene-2-base m.p.：101-103℃
20 ?OCH 3 ?CH 3 O CH CH CH H ?4-CH 3-C 6H 4 1H：1.80(d，3H)；2.38(s，3H)； 3.80(s，3H)；6.72(g，1H)； 6.80-7.50(m，8H)
21 ?OCH 3 ?CH 3 O CH CH CH H ?3-NH 2-C 6H 4 1H：1.82(d，3H)；(s，3H)； 6.60-7.25(m，8H)
Sequence number R 1U ?R 2 ???V ???X ??Y ???Z ??R 3 ???????????????R 4 Physical data
22 OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H Naphthalene alkene-2-base 1H：1.84(d，3H)；3.72(s，3H)； 6.68(g，1H)；7.00-8.00(m，11H)
23 OCH 3 ?CH 3 ?O ?N ?CH ?CH ?H ?3，4-(CH 3) 2-C 6H 3 ?m.p.：85°-87℃
24 OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?NH-C 6H 5 1H：1.82(d，3H)；3.72(s，3H)； 5.70(s，1H)；6.40(dd，1H)； 6.90-7.3(m，8H)；6.60-7.25(m， 9H)
25 OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H C(CH 3)＝NO-CH 2-[4-Cl-C 6H 4] 1H：1.78(d，3H)；2.25(s，3H)； 3.80(s，3H)；5.15(s，2H)； 6.70(g，1H)
26 OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H CH＝NO-CH(CH 3)-[4-Cl-C 6H 4] 1H：1.55(d，3H)；1.77(d，3H)； 3.70(s，3H)；5.30(g，1H)；6.70 (g，1H)；6.90-7.30(m，8H)； 8.05(s，1H)
27 OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H 1-CH＝CH 2， 1-CO 2CH 3-oxyethane-2-base 1H：1.72(d，3H)；3.75(s，3H)； 4.45(s，1H)；5.25(d，1H)；5.41 (d，1H)，5.90(dd，1H)， 6.75-7.25(m，5H)
28 OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?CHO 1H：1.80(d，3H)；3.70(s，3H)； 6.80(g，1H)；7.3-7.6(m，4H)； 10.0(s，1H)
29 OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?COCH 3 1H：1.81(d，3H)；2.61(s，3H)； 3.75(s，3H)；3.75(s，3H)；6.75 (g，1H)；7.10-7.60(，4H)
30 OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H I 1H：1.83(d，3H)；3.73(s，3H)； 6.75(g，1H)；6.8-7.4(m，4H)
Sequence number R 1U ?R 2 ????V ???X ??Y ???Z ??R 3 ????R 4 Physical data
?31 ?OCH 3 ?CH 3 O ?N ?CH ?CH ?H 3-Cl-C 6H 4 IR(cm -1)：1731，1593，1567， 1439，1315，1278
?32 ?OCH 3 ?CH 3 ?O ?N ?CH ?CH ?H 2-Cl-C 6H 4 IR(cm -1)：1732，1589，1577， 1442，1319，1238
?33 ?OCH 3 ?CH 3 ?O ?N ?CH ?CH ?H 4-Cl-C 6H 4 IR(cm -1)：1732，1594，1580， 1444，1241，796
?34 ?OCH 3 ?CH 3 ?O ?N ?CH ?CH ?H 3-CH 3-C 6H 4 IR(cm -1)：1733，1575，1440， 1317，1244，783
?35 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H C(CH 3)＝NOCH 3 1H：1.76(d，3H)；2.20(s，3H)； 3.70(s，3H)；4.00(s，3H)；6.70 (g，1H)，6.90-7.35(m，4H)
?36 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H CH＝NOCH 3 1H：1.80(d，3H)；3.72(s，3H)； 4.00(s，3H)；4.00(s，3H)；6.70 (g，1H)，6.82-7.40(m，4H)；8.05 (s，1H)
?37 ?OCH 3 ?CH 3 ?N(CH 3) ?CH ?CH ?CH ?H C(CH 3)＝NOCH 3 1H：1.72(d，3H)；2.20(s，3H)； 3.10(s，3H)；3.70(s，3H)；4.00 (s，3H)，6.82-7.40(m，4H)；8.05 (s，1H)，6.60(dd，1H)； 6.80-7.40(m，4H)
?38 ?OCH 3 ?CH 3 ?O ?CH ?CH CH ?H C(CH 3)＝NOCH 2CH 3 1H：1.30(t，3H)；1.80(d，3H)； 2.20(s，3H)；3.65(s，3H)；4.25 (g，2H)；6.80(g，1H)； 6.90-7.30(m，4H)
Sequence number R 1U ?R 2 ????V ????X ??Y ????Z ??R 3 ????R 4 Physical data
39 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H CH＝NOCH 2CH 3 1H：1.30(t，3H)；1.80(d，3H)； 3.68(s，3H)；4.25(g，2H)；6.80 (g，1H)；6.85-7.30(m，4H；8.05 (s，1H)
40 ?OCH 3 ?CH 3 N(CH 3) CH ?CH ?CH ?H C(CH 3)＝NOCH 2CH 3 1H：1.31(t，3H)；1.82(d，3H)； 2.25(s，3H)；3.10(s，3H)；3.70 (s，3H)；4.25(g，1H)；6.60(dd， 1H)；6.85-7.30(m，4H)
41 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H C(CH 3)＝NOCH(CH 3) 2 1H：1.26(d，6H)；1.79(d，3H)； 2.10(s，3H)；3.70(s，3H；4.45 (m，1H)；6.70(g，1H)；6.90-7.30 (m，4H)
42 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H CH＝NOCH(CH 3) 2 1H：1.25(d，6H)；1.80(d，3H)； 3.72(s，3H)；4.45(m，1H)；6.72 (g，1H)；6.70(g，1H)；6.90-7.30 (m，4H)
43 ?OCH 3 ?CH 3 N(CH 3) CH ?CH ?CH ?H C(CH 3)＝NOCH(CH 3) 2 1H：1.25(d，6H)；1.78(d，3H)； 2.05(s，3H)；3.10(s，3H)；3.70 (s，3H)；4.40(m，1H)；6.60 (g，1H)；6.90-7.25(m，4H)
44 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H C(CH 3)＝NOCH(CH 3)-[C 6H 5] 1H：1.55(d，3H)；1.77(d，3H)； 2.25(s，3H)；3.71(s，3H)；5.20 (g，1H)；6.80(g，1H)；7.05-7.40 (m，9H)
Sequence number ?R 1U ?R 2 ????V ???X ???Y ???Z ??R 3 ?????????????????R 4 Physical data
45 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H CH＝NOCH(CH 3)-[C 6H 5] 1H：1.60(d，3H)；1.80(d，3H)； 3.72(s，3H)；5.40(g，1H)；6.72 (g，1H)；6.90-7.40(m，9H)；8.05 (s，1H)
46 ?OCH 3 ?CH 3 ?N(CH 3) ?CH ?CH ?CH ?H C(CH 3)＝NOCH(CH 3)-[C 6H 5] 1H：1.61(d，3H)；3.09(s，3H)； 3.72(s，3H)；5.40(g，1H)；6.60 (g，1H)；6.80-7.35(m，9H)
47 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H C(CH 3)＝NOCH(CH 3)-[4-CH 3-C 6H 4] 1H：1.60(d，3H)；1.80(d，3H)； 2.25(s，3H)；2.35(s，3H)；3.70 (s，3H)；5.35(g，1H)；6.80 (g，1H)；6.90-7.30(m，8H)
48 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H CH＝NOCH(CH 3)-[4-CH 3-C 6H 4] 1H：1.61(d，3H)；1.78(d，3H)； 2.35(g，3H)；3.68(s，3H)；5.35 (g，1H)；6.90-7.25(m，8H)；8.06 (s，1H)
49 ?OCH 3 ?CH 3 ?N(CH 3) ?CH ?CH CH ?H C(CH 3)＝NOCH(CH 3)-[4-CH 3-C 6H 4] 1H：1.62(d，3H)；1.82(d，3H)； 2.21(g，3H)；2.29(g，3H)；3.05 (g，1H)；6.60-7.25(m，8H)
50 ?OCH 3 ?CH 3 ?N(CH 3) ?CH ?CH ?CH ?H C(CH 3)＝NOCH(CH 3)-[4-Cl-C 6H 4] 1H：1.58(d，3H)；1.84(d，3H)； 2.25(s，3H)；3.75(s，3H)；5.26 (g，1H)；6.70(g，1H)；6.92-7.35 (m，9H)
51 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H C(CH 3)＝NOCH(CH 3)-[4-Cl-C 6H 4] 1H：1.68(d，3H)；1.7?8(d，3H)； 2.30(s，3H)；3.05(s，3H)；3.78 (s，3H)；5.25(g，1H)；6.45 (dd，1H)；6.90-7.30(m，8H)
Sequence number ?R 1U ?R 2 ????V ????X ??Y ????Z ??R 3 ?????????????R 4 Physical data
52 ?OCH 3 CH 3 N(CH 3) CH ?CH ?CH ?H C(CH 3)＝NOCH 2-[4-Cl-C 6H 4] 1H：1.78(d，3H)；2.10(s，3H)； 3.75(s，3H)；3.90(s，2H)；5.20 (s，2H)；6.60(dd，1H)； 6.80-7.40(m，8H)
53 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H C(CH 3)＝NOCH(CH 3)- [4-C(CH 3) 3-C 6H 4] 1H：1.19(s，9H)；1.60(d，3H)； 1.80(d，3H)；2.25(g，3H)；3.72 (s，3H)；5.30(g，1H)；6.70 (g，1H)；7.10-7.40(m，8H)
54 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H CH＝NOCH(CH 3)- [4-C(CH 3) 3-C 6H 4] 1H：1.18(s，9H)；1.62(d，3H)； 1.82(d，3H)；3.72(s，3H)；5.31 (g，1H)；7.05-7.40(m，8H)；8.05 (s，1H)
55 ?OCH 3 ?CH 3 ?N(CH 3) CH ?CH ?CH ?H C(CH 3)＝NOCH(CH 3)- [4-C(CH 3) 3-C 6H 4] 1H：1.16(s，9H)；1.64(d，3H)； 1.78(d，3H)；3.74(s，3H)；5.30 (g，1H)；6.62(g，1H)；6.90-7.40 (m，8H)
56 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H C(CH 3)＝NOCH(CH 3)- [4-OCH 3-C 6H 4] 1H：1.60(d，3H)；2.25(s，3H)； 3.75(s，3H)；3.85(s，3H)；5.25 (g，1H)；6.80-7.30(m，9H)
57 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H CH＝NOCH(CH 3)- [4-OCH 3-C 6H 4] 1H：1.61(d，3H)；1.82(d，3H)； 3.75(s，3H)；3.84(s，3H)；5.25 (g，1H)；6.70(g，1H)；7.05-7.40 (m，8H)；8.05(s，1H)
58 ?OCH 3 ?CH 3 ?N(CH 3) ?CH ?CH ?CH ?H C(CH 3)＝NOCH(CH 3)- [4-OCH 3-C 6H 4] 1H：1.62(d，3H)；2.25(s，3H)； 3.65(s，3H)；3.80(s，3H)；5.25 (g，1H)；6.60(dd，1H)； 6.80-7.40(m，8H)
Sequence number ?R 1U ?R 2 ????V ????X ??Y ???Z ??R 3 ???????R 4 Physical data
59 ?OCH 3 ?CH 3 O ?CH ?CH ?CH ?H C(CH 3)＝NOCH(CH 3)- [3-CF 3-C 6H 4] 1H：1.65(d，3H)；1.79(d，3H)； 2.30(s，3H)；3.82(s，3H)；5.28 (g，1H)；6.70-7.30(g，1H)； 6.80-7.60(m，8H)
60 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H CH＝NOCH(CH 3)- [3-CF 3-C 6H 4] 1H：1.64(d，3H)；1.82(d，3H)； 3.70(s，3H)；5.40(g，1H)；6.72 (g，1H)；6.80-7.62(m，8H)；8.05 (s，1H)
61 ?OCH 3 ?CH 3 ?N(CH 3) CH ?CH ?CH ?H C(CH 3)＝NOCH(CH 3)- [3-CF 3-C 6H 4] 1H：1.65(d，3H)；2.30(s，3H)； 3.80(s，3H)；5.30(g，1H)；6.75 (g，1H)；6.82-7.60(m，9H)
62 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H C(CH 3)＝NOCH(CH 3)- [3，4-Cl 2-C 6H 3] 1H：1.68(d，3H)；1.75(d，3H)； 2.28(s，3H)；3.70(s，3H)；5.25 (g，1H)；6.70(g，1H)；6.80-7.40 (m，7H)
63 ?OCH 3 ?CH 3 ?O CH ?CH ?CH ?H CH＝NOCH(CH 3)- [3，4-Cl 2-C 6H 3] 1H：1.58(d，3H)；1.78(d，3H)； 3.72(s，3H)；5.22(g，1H)；6.72 (g，1H)；6.85-7.45(m，7H)
64 ?OCH 3 ?CH 3 ?N(CH 3) CH ?CH ?CH ?H C(CH 3)＝NOCH(CH 3)- [3，4-Cl 2-C 6H 3] 1H：1.62(d，3H)；1.76(d，3H)； 2.25(s，3H)；3.05(s，3H?)；3.72 (s，3H)；5.25(g，1H)；6.60 (g，1H)；6.80-7.40(m，7H)
65 ?OCH 3 ?CH 3 ?N(CH 3) CH ?CH ?CH ?H ?C 6H 5 1H：1.75(d，3H)；3.10(s，3H)； 6.60(g，1H)；6.85-7.60(m，9H)
?66 ?OCH 3 ?CH 3 ?N(CH 3) CH ?CH ?CH ?H ?4-CH 3-C 6H 4 m.p.＝116-117℃
Sequence number R 1U ?R 2 ???V ???X ?Y ???Z ??R 3 ???????????R 4 Physical data
67 OCH 3 CH 3 N(CH 3) CH CH CH H ?4-C 6H 5-C 6H 4 1H： 1.80(d，3H)；3.10(s，3H)；3.72 (s，3H；6.60(dd，1H)； 6.80-7.80(m，13H)
68 OCH 3 CH 3 O CH CH CH H ?4-{CH＝NOCH(CH 3)-[4-CH 3-C 6H 5}- ?C 6H 4 1H：1.60(d，3H)；1.77(d，3H)； 2.40(s，3H)；3.71(s，3H)；5.35 (g，1H)；6.72(g，1H)；6.80-7.60 (m，12H)；8.05(s，1H)
69 OCH 3 CH 3 O CH CH CH H ?4-{CH＝NOCH(CH 3)-[4-Cl-C 6H 5}- ?C 6H 4 1H：1.54(d，3H)；1.82(d，3H)； 3.72(s，3H)；5.32(g，1H)；6.70 (g，1H)；6.90-7.50(m，12H)； 8.05(s，1H)
70 OCH 3 CH 3 O CH CH CH H ?3-{CH＝NOCH(CH 3)-[4-Cl-C 6H 5}- ?C 6H 4 1H：1.55(d，3H)；1.80(d，3H?)； 3.70(s，3H)；5.40(g，1H)；6.80 (g，1H)；6.90-7.70(m，12H)； 8.20(s，1H)
71 NHCH 3 CH 3 O CH CH CH H ?3-{CH＝NOCH(CH 3)-[4-Cl-C 6H 5}- ?C 6H 4 m.p.：110℃
72 NHCH 3 CH 3 O CH CH CH H ?4-CHO-C 6H 4 1H：1.82(d，3H)；3.70(s，3H)； 6.78(g，1H)；6.90-7.40(m，4H)； 7.70；7.95(2d，4H)；10.05 (s，1H)
73 NHCH 3 CH 3 O CH CH CH H ?3-CHO-C 6H 4 1H：1.84(d，3H)；?3.72(s，3H)； 6.70(g，1H)；6.90-8.05(m，8H)； 10.06(s，1H)
74 NHCH 3 CH 3 O CH CH CH H ?COCH 3 m.p.：73°-76℃
Sequence number ?R 1U ?R 2 ???V ???X ??Y ????Z ??R 3 ??????????R 4 Physical data
75 ?NHCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?3，4-(CH 3) 2-C 6H 3 IR(Cm -1)：1735，1607，1479， 1436，1325，1199
76 ?NHCH 3 ?CH 3 ?O ?N ?CH ?CH ?H ?4-CH 3-C 6H 4 IR(cm -1)：1732，1595，1571， 1445，1239
77 ?OCH 3 ?CH 3 ?O ?N ?CH ?CH ?H ?CF 3 1H：1.82(d，3H)；3.70(s，3H)； 6.64(g，1H)；7.05-7.95(m，3H)
78 ?OCH 3 ?CH 3 ?O ?N ?CH ?CH ?H ?CH(CH 3) 2 1H： 1.22(d，6H)；1.81(d，3H)；2.88 (sep，1H)；3.72(s，3H)；6.68(g， 1H)；6.75-7.60(m，3H)
79 ?NHCH 3 ?CH 3 ?O ?N ?CH ?CH ?H ?3，4-(CH 3) 2-C 6H 3 m.p.：130℃
80 ?OCH 3 ?CH 3 ?O ?N ?N ?CH ?H ?3-F-C 6H 4 IR(cm -1)：1735，1566，1431， 1270.1133
81 ?OCH 3 ?CH 3 ?O ?N ?N ?CH ?H ?4-Cl-C 6H 4 ?m.p.：82-83℃
82 ?OCH 3 ?CH 3 ?O ?N ?N ?CCH 3 ?H ?3-CF 3-C 6H 4 1H：1.83(d，3H)；2.42(s，3H； 2.58(s，3H)；3.72(s，3H)；6.75 (g，1H)；7.20-7.40；8.20-8.30 (m，5H)
83 ?OCH 3 ?CH 3 ?O ?N ?N ?CCH 3 ?H ?C 6H 5 IR(cm -1)：1734，1561，1433， 1390，1264
84 ?OCH 3 ?CH 3 ?O ?N ?N ?CCH 3 ?H ?3-Cl-C 6H 4 1H：1.82(d，3H)；3.78(s，3H)； 6.70(g，1H)；6.95(d，1H)； 7.25-7.40；8.20-8.30(2m，4H)； 8.60(d，1H)
?85 ?OCH 3 ?CH 3 ?O ?N ?N ?CCH 3 ?H ?4-F-C 6H 4 ?m.p.：73°-75℃
Sequence number ?R 1U ?R 2 ????V ???X ??Y ????Z ??R 3 ?????????????R 4 Physical data
86 ?OCH 3 ?CH 3 ?O ?N ?N ?CCH 3 ?H ?3，4-(CH 3) 2-C 6H 3 1H:1.8 (d, 3H); 2.30,2.35,3.7 (s under every kind of situation, 3H); 6.7 (g, 1H); 6.8,7.2,8.05,8.1,8.65 (under every kind of situation) d, 1H)
87 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?2，4-Cl 2-C 6H 3 1H： 1.8(d，3H)；3.80(s，3H)；6.70 (g，1H)；6.90-7.50(m，7H)
88 ?OCH 3 ?CH 3 ?N(CH 3) ?CH ?CH ?CH ?H ?2，4-Cl 2-C 6H 3 1H： 1.8(d，3H)；3.15(s，3H)；3.7(s， 3H)；7.05(g，1H)，6.6-7.65 (m，7H)
89 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?3-{C(CH 3)＝NOCH 3}-C 6H 4 1H:1.8 (d, 3H); 2.15,3.7m, 4.0 (under every kind of situation) s, 3H); 6.75 (g, 1H), 7.1-7.9 (m, 8H)
90 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?3-{C(CH 3)＝NOCH(CH 3) 2}-C 6H 4 1H:1.35 (d, 6H); 1.86d, 3H); 2+3+3,85 (under every kind of situation) s, 3H); 4.5 (hep, and 1H) 6.75 (g, 1H); 6.85-7.9 (m, 8H)
91 ?OCH 3 ?CH 3 ?N(CH 3) ?CH ?CH ?CH ?H ?C(CH 3)＝NOCH 2-[3，4-Cl 2-C 6H 3] 1H:1.75 (d, 3H); (3.05-3.76 under every kind of situation) s, 3H); 6.98 (g, 1H); 6.55-7.5 (m, 7H)
Sequence number ?R 1U ?R 2 ????V ???X ??Y ???Z ???R 3 ???????????????R 4 Physical data
92 ?OCH 3 ?CH 3 ?N(CH 3) ?CH ?CH ?CH ?H ?C(CH 3)＝NOCH 2-[3-CF 3-C 6H 4] 1H:1.75 (d, 3H); 2.3,3.1,3.7 (under every kind of situation) s, 3H); 5.15 (s, 2H), 6.6-7.7 (m, 9H)
93 ?OCH 3 ?CH 3 ?N(CH 3) ?CH ?CH ?CH ?H ?C(CH 3)＝NOCH 2-[3-CH 3-C 6H 4] 1H:1.75 (d, 3H); 2.1,2.15,3.05,3.6 (under every kind of situation) s, 3H); 5.26 (s, 2H), 6.55-7.3 (m, 9H)
94 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?C(CH 3)＝NOCH 2-[3，4-Cl 2-C 6H 3] 1H:1.8 (d, 3H); 2.25,3.75 (under every kind of situation) s, 3H); 5.15 (s, 2H); 6.75 (g, 1H); 6.9-7.5 (m, 7H)
95 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH H ?C(CH 3)＝NOCH 2-[3-CF3-C 6H 4] 1H:1.75 (d, 3H); 2.3,4.5 (under every kind of situation) s, 3H); 5.25 (s, 2H); 6.75 (g, 1H); 6.8-7.7 (m, 8H)
96 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?C(CH 3)＝NOCH 2-[3-CH 3-C 6H 4] 1H:1.86 (d, 3H); 2.3,2.4,3.75 (under every kind of situation) s, 3H); 5.2 (s, 2H); 6.75 (g, 1H); 6.8-7.3 (m, 8H)
97 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?CH＝NOCH 2-[3，4-Cl 2-C 6H 3] 1H：1.8(d，1H)；3.85(s，3H)； 5.15(s，2H)，6.9(g，1H)； 6.9-7.5(m，7H)
98 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?CH＝NOCH 2-[3-CF 3-C 6H 4] 1H：1.78(d，3H)；3.7(s，3H)； 5.15(s，2H)，6.75(g，1H)； 6.8-7.75(m，8H)；8.1(s，1H)
Sequence number ?R 1U ?R 2 ????V ????X ??Y ????Z ?R 3 ?????????????R 4 Physical data
99 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?CH＝NOCH 2-[3-CH 3-C 6H 4] 1H:1.86 (d, 3H); 2.4,3.7 (in (under every kind of situation) s, 3H); 5.2 (s, 2H), 6.75 (g, 1H); 7.05-7.3 (m, 8H); 8.1 (s, 1H)
100 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?CH 2O-C 6H 5 1H：1.75(d，3H)；3.7(s，3H)； 5.05(s，2H)，6.7(g，1H)； 6.8-7.35(m，9H)
101 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?CH 2O-[2-CH 3， ?4-C(CH 3)＝NOCH 3-C 6H 3] 1H:1.8 (d, 3H); 2.2,2.3,3.7,3.95 (under every kind of situation) s, 3H); 6.75 (g, 1H); 6.95-7.56 (m, 7H)
102 ?OCH 3 ?CH 3 ?O ?CH CH ?CH ?H ?C≡C-C 6H 5 1H：1.8(d，3H)；3.70(s，3H)； 6.65(g，1H)；6.80-7.60(m，9H)
103 ?OCH 3 ?CH 3 ?N(CH 3) CH ?CH ?CH ?H ?C≡C-C 6H 5 1H：1.78(d，4H)；3.16(s，3H)； 7.0(g，1H)，6.65-7.6(m，9H)
104 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?O-C(CO 2CH 3)＝CH-CH 3 IR(cm -1)：1731，16.02[sic]， 1486，1436，1271，1141
105 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?CH 2O-[2-CH 3-C 6H 4] 1H:1.75 (d, 3H), 2.3u.3.7 (in (under every kind of situation) s, 3H); 5.1 (s, 2H); 6.75 (g, 1H); 6.8-7.35 (m, 8H)
106 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H ?CH 2O-[2，5-(CH 3) 2-C 6H 3] 1H:1.75 (d, 3H), 2.25,2.35,3.7 (under every kind of situation) s, 3H); 5.1 (s, 2H); 6.7-7.4 (m, 7H)
Sequence number ?R 1U ?R 2 ????V ????X ??Y ????Z ??R 3 ??????????????R 4 Physical data
107 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H CH 2O-[3，4-(CH 3) 2-C 6H 3] 1H:1.75 (d, 3H), 2.1,2.15,3.7 (under every kind of situation) S, 3H); 5.0 (s, 2H); 6.65-7.3 (m, 8H)
108 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H CH 2O-{2，5-(CH 3) 2， 4-[C(CH 3)＝NOCH 3]-C 6H 3} 1H:1.75 (d, 3H), 2.15,2.25,2.3,3.95 (under every kind of situation) s, 3H); 6.7-7.3 (7H)
109 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H CH 2ON＝C(CH 3)-[3，5-Cl 2-C 6H 3] 1H:1.8 (d, 3H), 2.2,3.7, (under every kind of situation) s, 3H); 5.2 (s, 2H); 6.75 (g, 1H); 6.8-7.6 (m, 7H)
110 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H CH 2ON＝C(CH 3)-C(CH 3)＝NOCH 3 1H:1.75 (d, 3H), 2.0,2.05,3.7,3.95 (under every kind of situation) s, 3H); 5.15 (s, 2H); 6.75 (g, 1H); 6.8-7.3 (m, 4H)
111 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H CH 2ON＝C(CH 3)-C(C 6H 5)＝NOCH 3 1H:1.75 (d, 3H), 2.2,3.75,3.9,3.95 (under every kind of situation) s, 3H); 5.0 (s, 2H); 6.75 (g, 1H); 6.8-7.2 (m, 9H)
112 ?OCH 3 ?CH 3 ?N(CH 3) ?CH ?CH ?CH ?H CH 2O-[2-CH 3-C 6H 4] 1H:1.75 (d, 3H), 2.3,3.1,3.7; (under every kind of situation) s, 3H); 5.05 (s, 2H); 6.55-7.36 (m, 9H)
Sequence number ?R 1U ?R 2 ????V ???X ??Y ???Z ??R 3 ?????????????R 4 ?Physical?data
113 ?OCH 3 ?CH 3 ?N(CH 3) ?CH ?CH ?CH ?H CH 2O-{2，5-(CH 3) 2， 4-[C(CH 3)＝NOCH 3]- C 6H 2} 1H:1.86 (d, 3H), 2.2,2.25,2.35,3.05,3.7, (4.0 under every kind of situation) s, 3H); 5.0 (s, 2H); 6.75-7.3 (m, 6H)
114 ?OCH 3 ?CH 3 ?N(CH 3) ?CH ?CH ?CH ?H CH 2ON＝C(CH 3)-[3，5-Cl 2-C 6H 3] m.p.：75°-76℃
115 ?OCH 3 ?CH 3 ?N(CH 3) ?CH ?CH ?CH ?H CH 2ON＝C(CH 3)-C(CH 3)＝NOCH 3 1H:4.75 (d, 3H); 1.95,2.0,2.1,3.95,3.98 (under every kind of situation) s, 3H); 5.15 (s, 2H), 6.95 (g, 1H); 6.75-7.3 (m, 4H)
116 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H 4-CH 3-azoles-2-base 1H:1.8 (d, 3H); 2.25,3.75 (under every kind of situation) s, 3H); 6.75; (g, 1H); 6.95-7.75 (m, 4H)
117 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H Pyridin-3-yl 1H：1.85(d，3H)；3.75(s，3H)； 6.75；(g，1H)； 6.95-8.9(m，8H)
118 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H 6-CH 3-pyridine-2-base 1H:1.8 (d, 3H); 2.65,3.75 (under every kind of situation) s, 3H); 6.75 (g, 1H); 6.9-7.76 (m, 7H)
119 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H Pyrimidine-5-base 1H：1.8(d，3H)；3.75(s，3H)； 6.8(g，1H)；6.95-7.3(m，4H)； 8.95(s，2H)；9.2(s，1H)
120 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H 3-CF 3-C 6H 4 1H：1.85(d，3H)；3.75(s，3H)； 6.75(g，1H)；6.85-7.9(m，8H)
Sequence number ?R 1U ?R 2 ???V ???X ??Y ????Z ??R 3 ??????R 4 Physical data
121 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H Furans-3-base 1H：1.8(d，3H)；3.75(s，3H)； 6.7-7.75(m，8H)
122 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?H Thiene-3-yl- 1H：1.8(d，3H)；3.75(s，3H)； 6.7-7.45(m，8H)
123 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?CH 3 ?3-CH 3-C 6H 4 m.p.：76-78℃
124 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?CH 3 ?4-CH 3-C 6H 4 m.p.：98-100℃
125 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?CH 3 ?3-Cl-C 6H 4 1H:1.8 (d, 3H); 2.2,3.75 (under every kind of situation) s, 3H); 6.7-7.5 (m, 7H)
126 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?CH 3 ?3-OCH 3-C 6H 4 1H:1.8 (d, 3H); 2.4,3.75,3.9 (under every kind of situation) s, 3H); 6.75-7.5 (g, 1H); 6.9-7.4 (m, 7H)
127 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?CH 3 ?3-F-C 6H 4 1H:1.8 (d, 3H); (2.4+3.7 under every kind of situation) s, 3H); 6.7-7.5 (m, 8H)
128 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?CH 3 ?4-Cl-C 6H 4 m.p.：105°
129 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?CH 3 ?3，4-Cl 2-C 6H 3 m.p.：84-86℃
130 ?OCH 3 ?CH 3 ?O ?CH ?CH ?CH ?Br ?4-Cl-C 6H 4 m.p.：129℃
131 ?NHCH 3 ?CH 3 ?O ?CH ?CH ?CH ?Br ?4-Cl-C 6H 4 m.p.：126-128℃
Embodiment to the harmful fungoid effect can show the effect of compound of Formula I to harmful fungoid by following test:
It is 20% emulsion that active compound is prepared into concentration in following mixture: the Nekanil of the pimelinketone of 70% (weight), 20% (weight) LN (Lutensol AP6 is based on the wetting agent with emulsification and dissemination of ethoxylated alkylphenol) and the Emulphor of 10% (weight) EL (Emulan EL is based on the emulsifying agent of ethoxylated fatty acid) and according to the desired concn dilute with water.
Compd A (embodiment 1 among the EP-A 383 117) and B (embodiment 50 among the EP-A 471 261) are used as comparative compound.Activity to cereal class Powdery Mildew
(kind: Fruhgold) blade is handled (application concentration 16ppm) with the water preparation of active compound, after about 24 hours, dusts to wheat with white powder germ (Erysiphe graminia var tritici) spore with stem and leaf of Wheat.The plant of Chu Liing was cultivated 7 days under 20-22 ℃ of relative humidity 75-80% in this way.Under 22-24 ℃ of relative humidity 65-70%, cultivated 8 days again.Measure the degree of morbidity.
In this test, with The compounds of this invention 4,9,13,23,25,33,59,66, %, 89,90,95,96,107,109,110,118 and the 123-130 plant of handling demonstrate 15% or lower infection rate, and the plant fungal infections rate that comparative compound A handles is 50%.Fungal infection rate with comparative compound the B plant of handling and (contrast) plant of being untreated is 70%.Activity to rice blast
With rice seedlings (kind: Tai Nong 67) spray until downward drip with active agent preparations.After 24 hours,, and under 22-24 ℃ of relative humidity 95-99%, kept 6 days the aqueous spore suspension spraying of plant with the fungi Magnaporthe grisea.Estimate with range estimation and carry out.
In this test, with The compounds of this invention 9,23,33,40,43,44,46,47,49,51,52,56,58,59,60-62,64-67,75,90-96,110,115,118 and the 123-129 plant of handling demonstrate 25% or lower infection rate, and the infection rate of the plant of comparative compound A and B and be untreated (contrast) reaches 80%.Embodiment to the animal pest effect
Can show the effect of compound of Formula I by following experiment to animal pest:
Be prepared as follows: the concentration of a. active compound in acetone is 0.1% solution: the concentration of b. active compound in following mixture is 10% emulsion: the Nekanil of the pimelinketone of 70% (weight), 20% (weight) LN (Lutensol AP6 is based on the wetting agent with emulsification and dissemination of ethoxylated alkylphenol) and the Emulphor of 10% (weight) EL (Emulan EL is based on the emulsifying agent of ethoxylated fatty acid) and under the situation of a., use acetone, water suitably is diluted to desired concn under the situation of b..
When experiment finishes, determine the minimum concentration (effect threshold values or Cmin) under each situation, under described minimum concentration, to compare with the untreated control experiment, compound still produces inhibiting rate or the mortality ratio of 80-100%.

Claims (13)

  1. The heteroaryloxy of formula I-,-sulfenyl-,-amino crotonate Substituting group wherein have following connotation: U be oxygen (O-), sulphur (S-) or amino (NH-); V be oxygen (O-), sulphur (S-), amino (NH-) or alkylamino [N (alkyl)-]; X, Y and Z be independently of each other=N-or=CR 3-; R 1And R 2Be C independently of each other 1-C 4-alkyl; R 3Be hydrogen, cyano group, nitro, halogen, C 1-C 4-alkyl, C 1-C 4-haloalkyl, C 1-C 4-
    Alkoxyl group, C 1-C 4-halogenated alkoxy, C 1-C 4-alkylthio and C 1-C 4-halogenated alkylthio; R 4Be one with the peroxy main structure Direct Bonding or logical, sulfydryl, amino, carboxyl or carbonyl ammonia
    The organic group that base links to each other with main structure.
  2. 2. according to the formula I compound of claim 1, R wherein 4Be A 1-W 1-group, A in the formula 1And W 1Following connotation: W is arranged 1Be a direct key, oxygen, sulphur, amino or alkylamino; A 1Be alkyl, alkenyl or the alkynyl that does not replace or replace, or
    Saturated or the undersaturated cyclic group of part that does not replace or replace, it is except carbon atom, also
    Contain by the heteroatoms that is selected from oxygen, sulphur and nitrogen-atoms as ring element;
    Or
    The aromatic nucleus that does not replace or replace, it except carbon atom, also can contain by be selected from oxygen, sulphur and
    The heteroatoms of nitrogen-atoms is as ring element.
  3. 3. according to the formula I compound of claim 1, R wherein 4Be CH 2-O-A 1Group, A in formula 1Have following connotation:
    Saturated or the undersaturated cyclic group of part that does not replace or replace, it also contains by the heteroatoms that is selected from oxygen, sulphur and nitrogen-atoms as ring element except carbon atom; Or the aromatic nucleus that does not replace or replace, it also can contain by the heteroatoms that is selected from oxygen, sulphur and nitrogen-atoms as ring element except carbon atom.
  4. 4. according to the formula I compound of claim 1, R wherein 4Be A 2-W aN=CR a-, A in formula 2, W aAnd R aFollowing meanings is arranged: R aBe hydrogen, alkyl or haloalkyl; W aBe oxygen, amino or alkylamino; A 2The alkyl, alkenyl or the alkynyl that are hydrogen, do not replace or replace, or
    Saturated or the undersaturated cyclic group of part that does not replace or replace, it is except carbon atom, also
    Contain by the heteroatoms that is selected from oxygen, sulphur and nitrogen-atoms as ring element;
    Or
    The aromatic nucleus that does not replace or replace, it also contains by being selected from oxygen, sulphur and nitrogen former except carbon atom
    The heteroatoms of son is as ring element.
  5. 5. according to the formula I compound of claim 1, R wherein 4Be A 3-CR b=NOCHR c-group, R in formula b, R cAnd A 3Following connotation: R is arranged bBe hydrogen, cyano group, nitro, halogen, alkyl, haloalkyl, cycloalkyl, alkoxyl group, haloalkane
    Oxygen base or the aryl that does not replace or replace; R cBe hydrogen, alkyl or cycloalkyl; A 3Be alkyl, alkenyl or the alkynyl that does not replace or replace, or
    Saturated or the undersaturated cyclic group of part that does not replace or replace, it is except carbon atom, also
    Contain by the heteroatoms that is selected from oxygen, sulphur and nitrogen-atoms as ring element; Or
    The aromatic nucleus that does not replace or replace, it also contains by being selected from oxygen, sulphur and nitrogen former except carbon atom
    The heteroatoms of son is as ring element.
  6. 6. according to the formula I compound of claim 1, R wherein 4Be A 4-ON=CR d-CR e=NO-CHR f-group, A in formula 4, R d, R eAnd R fFollowing connotation: R is arranged dAnd R eBe hydrogen, cyano group, nitro, halogen, alkyl, haloalkyl, cycloalkyl, alkoxyl group,
    Halogenated alkoxy or the aryl that does not replace or replace; R fBe hydrogen, alkyl or cycloalkyl; A 4Be alkyl, alkenyl or the alkynyl that does not replace or replace, or
    Saturated or the undersaturated cyclic group of part that does not replace or replace, it is except carbon atom, also
    Contain by the heteroatoms that is selected from oxygen, sulphur and nitrogen-atoms as ring element; Or
    The aromatic nucleus that does not replace or replace, it also contains by being selected from oxygen, sulphur and nitrogen former except carbon atom
    The heteroatoms of son is as ring element.
  7. 7. according to the formula I compound of claim 1, wherein the combination of radicals X, Y and Z has following connotation:
    X, Y and Z are=CR 3-; Or
    X is=N-and Y and Z be=CR 3-; Or
    Y is=N-and X and Z be=CR 3-; Or
    Z is=N-and X and Y be=CR 3-; Or
    X is=CR 3-with Y and Z be=N-; Or
    Y is=CR 3-with X and Z be=N-; Or
    Z is=CR 3-with X and Y be=N-; Or
    X, Y and Z are=N-.
  8. One kind prepare according to claim 1, wherein V is the method for the formula I compound of oxygen or sulphur, it comprises, in the presence of a kind of alkali, with known mode itself with corresponding formula IIa alcohol or mercaptan
    Figure A9619470100051
    IIa (Y=O, S) with the reaction of formula III a crotonate, L wherein is can be by the leavings group of nucleophilic displacement.
  9. One kind prepare according to claim 1, wherein V is the method for the formula I compound of amino or alkylamino, it comprises, in the presence of protonic acid, with known mode itself with corresponding formula IIb amine IIb (V=NH, N-alkyl) reacts with α-ketone group carbonyl compound of formula IV,
    Figure A9619470100061
  10. 10. composition that is suitable for preventing and treating animal pest and harmful fungoid, it contains solid or liquid vehicle and according to the compound of Formula I in the claim 1.
  11. 11. the formula I application of compound in the claim 1 is used to prepare the composition that is suitable for preventing and treating animal pest or harmful fungoid.
  12. 12. a methods for fighting harmful mushrooms, it comprises, with effectively, the compound of Formula I according in the claim 1 of amount is handled fungi or to be protectedly made it not to be subjected to material, plant, soil or the seed of encroaching on.
  13. 13. a method of preventing and treating animal pest, it comprises, handles insect or to be protectedly makes it not to be subjected to material, plant, soil or the seed of encroaching on the compound of Formula I according in the claim 1 of significant quantity.
CN96194701A 1995-05-09 1996-04-26 (Het) Aryloxy-, -Thio-, Aminocrotonates, method of preparing them and their use Pending CN1187814A (en)

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