CN1183961A - Liniment film for onychomycosis and its preparation technology - Google Patents
Liniment film for onychomycosis and its preparation technology Download PDFInfo
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- CN1183961A CN1183961A CN 97122034 CN97122034A CN1183961A CN 1183961 A CN1183961 A CN 1183961A CN 97122034 CN97122034 CN 97122034 CN 97122034 A CN97122034 A CN 97122034A CN 1183961 A CN1183961 A CN 1183961A
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- film
- liniment
- onychomycosis
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- itraconazole
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Abstract
The present invention belongs to the field of medicine preparation. The liniment film for onychomycosis consists of antifungal medicine, cellulose nitrate, acetone, butyl acetate, ethyl lactate, salicylic acid, benzoic acid and nitrogen ketone. The film is easy to use and high in curative effect, and has no irritation and side effect.
Description
The invention belongs to the medicament preparation field, be specifically related to a kind of liniment film for onychomycosis and preparation technology.
Tinea unguium is commonly called as " tinea unguium ", mostly is due to the passing of time tinea manus and pedis spread, and be a kind of commonly encountered diseases and the frequently-occurring disease of department of dermatologry.Tinea unguium mostly is trichophyton purpureatum, and its bacterium infects and causes the fingernail distortion, becomes fragile, and tarnishes, and is plump gradually.Initial stage is light yellow, is dirty yellow or dirty taupe later on, and the surface is uneven, the many elder generations of morbidity are begun by the free edge or the lateral margin of first, are the worm-eaten shape, with the passing of time the deck have been eaten into, separate with nail matrix on the deck as a result, forms the alcove shape, also can gather the cheesy epithelium of keratinization under first.Tinea unguium is the most obstinate refractory a kind of in the dermatophytes, and the course of disease is slow, and the character stubbornness does not often heal all the life.At present, Chinese Hospitals preparation standard is compiled by bureau of drug administration of prior art Ministry of Health of the People's Republic of China. and second edition .1995:77, adopt following method to the treatment of tinea unguium: one, endo-medicine treatment.Griseofulvin, though ketoconazole has certain curative effect to tinea unguium, the time that need take medicine is long, and side effect is big, the heart, liver, kidney is all had in various degree infringement, so be difficult to adhere to taking medicine.Two, local application's smelting is treated.At present the local application to tinea unguium mainly contains medicine for external use such as glacial acetic acid and salicylic acid, not only the course of treatment long, and curative effect is low.Three, surgical operation therapy.The dermatologist who has also adopts surgical operation, pulls out the trouble first, reaches therapeutic effect.But a plurality of fingers are all suffered from tinea unguium, and the patient is very painful, the method that should not extensively adopt operation to pull out.
The object of the present invention is to provide a kind of easy to use, evident in efficacy, the liniment film for onychomycosis agent that treatment cycle is short.
Technical scheme of the present invention is as follows:
1. the employing of this medicine film is water insoluble, water white transparency, and good film-forming property, the celluloid of difficult drop-off is as filmogen.2. adopt double solvent acetone, butyl acetate, ethyl lactate as solvent,, reduce the zest of solvent skin in order to increase the dissolubility of celluloid.3. employing antifungal drug is as fat-soluble itraconazole, fluconazol, ketoconazole; The itraconazole effect is best.4. adopt salicylic acid, benzoic acid as softening agent, but soften cuticle, and bacteriostasis is arranged.
A: percentage by weight prescription:
Itraconazole 5-20%
Celluloid 5-50%
Salicylic acid 10-30%
Benzoic acid 20-60%
Azone 5-10%
B: the double solvent prescription is (percent by volume)
Acetone 40-60%
Butyl acetate 20-30%
Ethyl lactate 20-30%
Contain A prescription 45-70g among every 500mlA+B.
Preparation method: acetone, butyl acetate, ethyl lactate are pressed the formula proportion mix homogeneously.
Celluloid, itraconazole, salicylic acid, benzoic acid, azone are dissolved in wherein by formula proportion, disturb and mix evenly, packing gets final product.
This liniment film for onychomycosis criterion of therapeutical effect.Healing-sick first disappears fully.Produce effects-sick first disappears greater than 70%.Improvement-sick first the 50-70% that disappears.Invalid-sick first disappears below 50%.Treating the course of treatment is three months, and judges curative effect.Total case load 15 examples, the men and women half and half.Effective 10 examples of two weeks back observation are cured 2 examples.Observe effective 12 examples after one month, cure 2 examples.Observe effective 10 examples after three months, cure 4 examples, invalid 1 example, total effective rate is 94%.
Model case:
Example 1: the Suzhou Huang of retired employees of department store, right hand forefinger and middle finger, left hand thumb, forefinger are suffered from surplus the tinea unguium 30 year, once oral griseofulvin is not adhered to greatly because of side effect, is coated with liniment film for onychomycosis after two weeks, effective 2 refer to, after three months all effectively.
Example 2: Li He residential district, Suzhou Wang, 10 refer to all get involved, and with back three months, cure 5 and refer to, and 4 fingers take a turn for the better.
Embodiment 1: take by weighing itraconazole 5g, celluloid 5g, salicylic acid 15g, benzoic acid 30g, azone 5g respectively.
Acetone 300ml, butyl acetate 100ml, ethyl lactate 100ml are mixed and disturb and mix evenly, itraconazole, celluloid, salicylic acid, benzoic acid, azone are dissolved in wherein again, disturb and mix evenly, making cumulative volume is 500ml, and after treating to dissolve fully, packing gets final product.
Embodiment 2: take by weighing ketoconazole 10g, celluloid 25g, salicylic acid 5g, benzoic acid 10g, azone 5g respectively.
Acetone 200ml, butyl acetate 150ml, ethyl lactate 150ml are mixed and disturb and mix evenly, ketoconazole, celluloid, salicylic acid, benzoic acid, azone are dissolved in wherein again, disturb and mix evenly, making cumulative volume is 500ml, and after treating to dissolve fully, packing gets final product.
Embodiment 3: take by weighing fluconazol 2.5g, celluloid 2.5g, salicylic acid 15g, benzoic acid 30g, azone 2.5g respectively.
Other step is with embodiment 2.
The extensive patients reflection of filming of embodiment preparation: it is easy to use originally to film, only need use once every day, be stained with a small amount of medicinal liquid with cotton swab or small brushes, be coated in and suffer from the first, just can form the water white thin film of one deck, it is also water insoluble can not come off, thereby the therapeutical effect time is long, good penetrability, evident in efficacy.
Claims (4)
1. liniment film for onychomycosis is characterized in that:
A: fill a prescription to by weight percentage:
Itraconazole 5-20%
Celluloid 5-50%
Salicylic acid 10-30%
Benzoic acid 20-60%
Azone 5-10%
B: the double solvent prescription is (percent by volume)
Acetone 40-60%
Butyl acetate 20-30%
Ethyl lactate 20-30%
Contain A prescription 45-70g among every 500mlA+B.
2. liniment film for onychomycosis according to claim 1 is characterized in that: itraconazole can replace with fluconazol or ketoconazole in the prescription.
3. the preparation technology of a liniment film for onychomycosis, it is characterized in that: earlier acetone, butyl acetate, ethyl lactate are pressed the formula proportion mix homogeneously, again celluloid, itraconazole, salicylic acid, benzoic acid, azone are dissolved in wherein by formula proportion, disturb to mix evenly and get final product.
4. liniment film for onychomycosis is characterized in that: this films is application as treatment tinea unguium medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97122034A CN1073845C (en) | 1997-12-16 | 1997-12-16 | Liniment film for onychomycosis and its preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97122034A CN1073845C (en) | 1997-12-16 | 1997-12-16 | Liniment film for onychomycosis and its preparation technology |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1183961A true CN1183961A (en) | 1998-06-10 |
| CN1073845C CN1073845C (en) | 2001-10-31 |
Family
ID=5176629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97122034A Expired - Fee Related CN1073845C (en) | 1997-12-16 | 1997-12-16 | Liniment film for onychomycosis and its preparation technology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1073845C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000015202A3 (en) * | 1998-09-10 | 2001-08-09 | Ipr Inst Pharm Res Riehen Ag | Topical application products |
| WO2008128627A3 (en) * | 2007-04-20 | 2009-09-24 | Bioequal Ag | Topically applicable fungicide agents for treating nails |
| CN102335175A (en) * | 2011-07-27 | 2012-02-01 | 陈忠和 | Medicament for removing onychomycosis |
-
1997
- 1997-12-16 CN CN97122034A patent/CN1073845C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000015202A3 (en) * | 1998-09-10 | 2001-08-09 | Ipr Inst Pharm Res Riehen Ag | Topical application products |
| WO2008128627A3 (en) * | 2007-04-20 | 2009-09-24 | Bioequal Ag | Topically applicable fungicide agents for treating nails |
| AU2008241071B2 (en) * | 2007-04-20 | 2013-11-14 | Bioequal Ag | Topically applicable fungicide agents for treating nails |
| RU2573025C2 (en) * | 2007-04-20 | 2016-01-20 | Байоэквал Аг | Topical fungicidal agents for treating nail disorders |
| CN102335175A (en) * | 2011-07-27 | 2012-02-01 | 陈忠和 | Medicament for removing onychomycosis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1073845C (en) | 2001-10-31 |
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