CN118201605A - 基于poegma的脂质纳米粒子 - Google Patents

基于poegma的脂质纳米粒子 Download PDF

Info

Publication number
CN118201605A
CN118201605A CN202280071413.1A CN202280071413A CN118201605A CN 118201605 A CN118201605 A CN 118201605A CN 202280071413 A CN202280071413 A CN 202280071413A CN 118201605 A CN118201605 A CN 118201605A
Authority
CN
China
Prior art keywords
lipid
lipid nanoparticle
poegma
mrna
phosphatidylethanolamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280071413.1A
Other languages
English (en)
Chinese (zh)
Inventor
阿舒托什·奇尔科提
索曼·萨哈
帕鲁尔·司罗熙
安格斯·哈科纳尔
索纳尔·德什潘德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University filed Critical Duke University
Publication of CN118201605A publication Critical patent/CN118201605A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202280071413.1A 2021-10-25 2022-10-25 基于poegma的脂质纳米粒子 Pending CN118201605A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163271595P 2021-10-25 2021-10-25
US63/271,595 2021-10-25
PCT/US2022/078659 WO2023076902A1 (en) 2021-10-25 2022-10-25 Poegma-based lipid nanoparticles

Publications (1)

Publication Number Publication Date
CN118201605A true CN118201605A (zh) 2024-06-14

Family

ID=86158533

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280071413.1A Pending CN118201605A (zh) 2021-10-25 2022-10-25 基于poegma的脂质纳米粒子

Country Status (6)

Country Link
US (1) US20250049729A1 (https=)
EP (1) EP4422605A4 (https=)
JP (1) JP2024541924A (https=)
CN (1) CN118201605A (https=)
CA (1) CA3236153A1 (https=)
WO (1) WO2023076902A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117562869B (zh) * 2023-05-05 2024-07-16 中南大学湘雅医院 一种治疗关节疼痛的氢氧化镁纳米粒、其制备方法及应用
WO2025067389A1 (en) * 2023-09-28 2025-04-03 Immorna (hangzhou) Biotechnology Co., Ltd. Lipid complex nanoparticle for lung-targeted delivery of nucleic acid therapeutic agent
WO2025081189A1 (en) * 2023-10-12 2025-04-17 Georgia Tech Research Corporation Methods and compositions for lipid nanoparticle (lnp) mediated delivery of mrna encoded synthetic antigens for universal tumor targeting by car t cells
CN118001253A (zh) * 2024-02-07 2024-05-10 北京大学 一种肾脏靶向mRNA-LNP递送技术和疾病治疗方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7799565B2 (en) * 2004-06-07 2010-09-21 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering RNA
US8497356B2 (en) 2009-02-17 2013-07-30 Duke University Biomolecule polymer conjugates and methods for making the same
US10364451B2 (en) 2013-05-30 2019-07-30 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
WO2017112825A2 (en) 2015-12-21 2017-06-29 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
WO2020051220A1 (en) 2018-09-04 2020-03-12 The Board of the Regents of the University of Texas System Compositions and methods for organ specific delivery of nucleic acids
CN112996519B (zh) * 2018-09-04 2025-02-28 德克萨斯大学系统董事会 用于核酸的器官特异性递送的组合物和方法
AU2021232069A1 (en) * 2020-03-05 2022-11-03 Flagship Pioneering Innovations Vi, Llc Host defense suppressing methods and compositions for modulating a genome
MX2023000806A (es) * 2020-07-17 2023-04-11 Generation Bio Co Métodos para encapsular polinucleótidos en tamaños reducidos de nanopartículas lipídicas y formulación novedosa de estos.
CN112961065B (zh) * 2021-02-05 2023-03-14 嘉晨西海(杭州)生物技术有限公司 一种可电离脂质分子及其制备方法及其在制备脂质纳米颗粒的应用
WO2022212911A1 (en) 2021-04-01 2022-10-06 Duke University Poegma copolymer conjugates and methods of treating diseases

Also Published As

Publication number Publication date
US20250049729A1 (en) 2025-02-13
WO2023076902A1 (en) 2023-05-04
JP2024541924A (ja) 2024-11-13
EP4422605A4 (en) 2025-06-18
EP4422605A1 (en) 2024-09-04
CA3236153A1 (en) 2023-05-04

Similar Documents

Publication Publication Date Title
CN118201605A (zh) 基于poegma的脂质纳米粒子
AU2018378812B2 (en) Compositions and methods of treating muscle atrophy and myotonic dystrophy
US9080186B2 (en) Compositions comprising cationic amphiphiles and colipids for delivering therapeutic molecules
WO2022140404A1 (en) Zwitterionic lipid nanoparticle compositions, and methods of use
TW201019969A (en) Branched cationic lipids for nucleic acids delivery system
BR112014016562B1 (pt) Estrutura de oligo-rna de dupla hélice, nanopartícula e método de preparação
TW201004658A (en) Nanoparticle compositions for nucleic acids delivery system
Felber et al. siRNA nanocarriers based on methacrylic acid copolymers
EP4520349A1 (en) Interfering rna for inhibiting b7-h3 gene expression and use thereof
EP4626400A1 (en) Novel polyglycerol-conjugated lipids and lipid nanoparticle compositions comprising the same
WO2024086929A1 (en) Lipid nanoparticle formulations for anti-sense oligonucleotide delivery
KR101685304B1 (ko) 간 조직 특이적 유전자 발현 억제인자 전달용 나노리포좀
CN117658848A (zh) 递送治疗剂的脂质化合物及其应用
CN117264955A (zh) 一种抑制top1基因表达的干扰rna及其应用
WO2023122062A1 (en) Methods for enhanced nucleic acid delivery
WO2025090663A1 (en) Novel polyglycerol-conjugated lipids and lipid nanoparticle compositions comprising the same
CN121793987A (zh) 使用pln靶向性抗体-寡核苷酸缀合物的组合物和方法
JP2025540076A (ja) 核酸、イオン化可能な脂質、ステロール、脂質アンカーポリマー、及びヘルパー脂質を含む脂質ナノ粒子、それらの使用
CN119947757A (zh) 杂合肽树枝状聚合物系统及肝外递送
JP2025528441A (ja) 核酸を含む活性剤の送達のための組成物及び方法
EP2666856A1 (en) Composition for inhibiting target gene expression
WO2025072150A1 (en) Zwitterionic lipid nanoparticle compositions, and methods of use
WO2025043730A1 (en) Lipid compounds for delivery of therapeutic agents and preparation method and use thereof
WO2026090175A2 (en) Propargyl amino-ionizable lipid compounds, lipid nanoparticles (lnps), and methods of making and using same for gene editing
WO2026064512A1 (en) Polyglycerol-conjugated lipids and lipid nanoparticle compositions comprising the same

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination