CN118190718A - An ophthalmic Chinese medicinal preparation and its active ingredient extraction method - Google Patents
An ophthalmic Chinese medicinal preparation and its active ingredient extraction method Download PDFInfo
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Abstract
The invention relates to the technical field of preparation of Chinese herbal medicine preparations, in particular to an extraction method of active ingredients of an ophthalmic Chinese herbal medicine preparation. Step S1, raw material treatment; s2, soaking; s3, heating and extracting; and S4, preparing a finished product. According to the invention, the Chinese herbal medicine raw materials are soaked, so that the dry medicinal materials fully absorb the solvent, the release of the active ingredients in the medicinal materials is promoted through heating, the solvent content of the medicinal materials is analyzed through automatic intelligent monitoring on the soaking process, the water absorption capacity of specific medicinal materials is detected in real time, the soaking efficiency is improved, the quality of the medicinal materials is ensured, the active ingredients are prevented from being deactivated due to the fact that the temperature is too high through detecting the heating extraction process, and meanwhile, the intelligent calculation is performed on the extraction rate, the real-time performance and the extraction efficiency of the detection are improved, the active ingredients in the prepared Chinese herbal medicine preparation are ensured to be effective, and therefore, the effects of preventing and delaying vision growth can be achieved by relieving eye fatigue and dry eyes.
Description
Technical Field
The invention relates to the technical field of preparation of Chinese herbal medicine preparations, in particular to an ophthalmic Chinese herbal medicine preparation and an extraction method of active ingredients thereof.
Background
Eye dryness, eye astringency and eye soreness and distention, blurred vision and even vision decline directly affect the work and life of people, and eye fatigue is mainly caused by that when people pay attention to watch screens of electronic products such as televisions, computers or mobile phones in normal times, eye blinking times are reduced, tear secretion is correspondingly reduced, and meanwhile, eyes are strongly stimulated by flickering screens, so that how to improve eye fatigue and eye dryness to avoid myopia or delay vision growth becomes an interesting topic, and meanwhile, how to ensure medicine extraction quality and efficiency in the preparation process of Chinese herbal medicine eye drops becomes a research direction of related researchers.
Chinese patent publication No.: CN111544468B, its technical point is to provide a eye lotion for eye care, including traditional Chinese medicine extract, hypromellose, vitamin E acetate and vitamin B6, can effectively alleviate and prevent xerophthalmia from occurring; however, in the existing preparation technology of Chinese herbal medicine eyedrops, the processes of soaking and extraction are rarely disclosed through intelligent monitoring, so that the phenomenon that medicinal materials are soaked in solvents for a long time is avoided, the medicinal effects of the medicinal materials are weakened, and hidden microorganisms and molds in the medicinal materials are more diffused in the solvents, so that the safety of the medicinal materials is affected, the medicinal materials are softened, the quality is reduced, and meanwhile, the phenomenon that the medicinal materials absorb the solvents to reach a saturated state is difficult to ensure, so that the extraction effect is ensured.
Disclosure of Invention
Therefore, the invention provides an ophthalmic traditional Chinese medicine preparation and an extraction method of active ingredients thereof, which are used for solving the problem that the extraction efficiency of medicinal materials is low because the release quality of active ingredients in the medicinal materials is difficult to ensure due to the lack of a real-time detection medicinal material soaking and extracting process in the prior art.
In order to achieve the above object, the present invention provides an ophthalmic traditional Chinese medicine preparation and an extraction method of active ingredients thereof, comprising,
Step S1, raw material treatment, namely respectively cutting, weighing and mixing the Chinese herbal medicine raw materials to form mixed raw materials, adding the mixed raw materials into an intelligent leaching device, adding a soaking solution into the intelligent leaching device to form a solid-liquid mixture, and stirring and uniformly mixing the solid-liquid mixture;
Step S2, soaking, namely sampling and detecting the soaking process of the mixed raw materials, determining the real-time soaking amount and standard soaking amount range of the mixed raw materials according to the weight of the raw materials to be detected before and after squeezing, judging the current soaking time according to the preset time range when the real-time soaking amount is smaller than the first standard soaking amount, determining whether the preset feed-liquid ratio is judged, and adjusting the first preset time when the real-time soaking amount is larger than the second standard soaking amount;
Step S3, heating and extracting, namely heating and extracting the solid-liquid mixture when the real-time infiltration amount is judged to be within the standard infiltration amount range, obtaining a real-time solution image of the solution in the extracting process, calculating a real-time brightness difference value and a real-time extraction rate according to the real-time solution image, comparing the real-time extraction rate with the standard extraction rate when the real-time brightness difference value is judged to be smaller than or equal to the standard brightness difference value, adjusting the standard extraction time length when the real-time extraction rate is judged to be larger than or equal to the standard extraction rate and longer than the standard extraction time length, and adjusting the preset extraction temperature when the real-time brightness difference value is judged to be smaller than or equal to the standard brightness difference value and the real-time extraction rate is judged to be smaller than the standard extraction rate;
And S4, preparing a finished product, filtering the solid-liquid mixture, collecting filtrate, concentrating and drying to form Chinese herbal medicine powder.
Further, in the step S2, a standard infiltration amount range is set, the humidity of the mixed raw materials is detected and determined at a plurality of sampling points, the raw materials to be detected are taken from the solid-liquid mixture to a humidity detection layer through a grabbing mechanism to be squeezed, the weight value of the raw materials to be detected before the squeezing is obtained and recorded as a real-time infiltration amount, the real-time infiltration amount is compared with the standard infiltration amount range,
If the real-time infiltration amount is within the standard infiltration amount range, comparing the real-time brightness difference value with the standard brightness difference value to determine whether the extraction state of the mixed raw materials is normal;
If the real-time infiltration amount is not in the standard infiltration amount range, comparing the real-time infiltration amount with the first standard infiltration amount and the second standard infiltration amount respectively to determine whether to adjust the soaking state.
Further, in the step S2, when it is determined that the real-time infiltration amount is not within the standard infiltration amount range, the real-time infiltration amount is compared with the first standard infiltration amount and the second standard infiltration amount, respectively,
If the real-time infiltration amount is smaller than the first standard infiltration amount, acquiring the current soaking time length of the mixed raw materials, and comparing the current soaking time length with a preset time length range to determine whether to adjust the first preset time length.
Further, in the step S2, when it is determined that the real-time infiltration amount is not within the standard infiltration amount range, the real-time infiltration amount is compared with the first standard infiltration amount and the second standard infiltration amount, respectively,
If the real-time infiltration amount is larger than the second standard infiltration amount, acquiring the current soaking time of the mixed raw materials, and adjusting the first preset time according to the real-time infiltration amount and the second standard infiltration amount.
Further, in the step S2, a preset feed-liquid ratio of the solid-liquid mixture is set, when it is determined that the real-time infiltration amount of the raw material to be detected is smaller than the first standard infiltration amount, a current soaking time length of the mixed raw material is obtained, the current soaking time length is compared with a preset time length range,
If the current soaking time length is longer than the second preset time length, adjusting the preset feed liquid ratio according to the current soaking time length and the second preset time length;
Wherein Gc '=gc× [1+ (Ts-Tc 2)/Ts ], gc represents a set preset feed-to-liquid ratio, gc' represents an adjusted preset feed-to-liquid ratio, ts represents a current soaking period of the mixed raw material, tc2 represents a set second preset period of time, the preset period of time range is a fixed value, and the second preset period of time is a maximum value of the preset period of time range and varies with the first preset period of time.
Further, when the real-time infiltration amount of the mixed raw materials is judged to be within the standard infiltration amount range, the solid-liquid mixture is heated, two real-time solution images corresponding to two end points of a preset detection period are obtained through the image pickup mechanism, a real-time brightness difference value is calculated according to the two real-time solution images, the real-time brightness difference value is compared with the standard brightness difference value, when the real-time brightness difference value is judged to be smaller than or equal to the standard brightness difference value, the real-time extraction rate of the mixed raw materials is calculated, and the real-time extraction rate is compared with the standard extraction rate to determine whether the preset extraction temperature is adjusted.
Further, when the real-time brightness difference value is less than or equal to the standard brightness difference value, the real-time brightness difference value calculated in the last preset detection period is obtained, the real-time brightness difference value in the current preset detection period is subtracted by the real-time brightness difference value in the last preset detection period and divided by the preset detection period to obtain the real-time extraction rate of the mixed raw materials, the real-time extraction rate is compared with the standard extraction rate,
If the real-time extraction rate is greater than or equal to the standard extraction rate, judging the real-time extraction time length according to the standard extraction time length to determine whether to adjust the standard extraction time length;
If the real-time extraction rate is smaller than the standard extraction rate, adjusting the preset extraction temperature, continuing to calculate the real-time brightness difference value, and comparing the real-time brightness difference value with the standard brightness difference value to judge the real-time brightness difference value until the real-time brightness difference value is smaller than or equal to the standard brightness difference value again, and finishing the extraction treatment of the mixed raw materials when the real-time extraction rate is smaller than the standard extraction rate;
Wherein Qs '=qs× [1+ (Vb-Vs)/Vs ], qs represents a set preset extraction temperature, qs' represents an adjusted preset extraction temperature, vb represents a set standard extraction rate, and Vs represents a calculated real-time extraction rate.
Further, in the step S3, a standard extraction duration of the mixed raw materials is set, when the real-time extraction rate is determined to be greater than or equal to the standard extraction rate, the real-time extraction duration corresponding to the current time is obtained, the real-time extraction duration is determined according to the standard extraction duration,
If the real-time extraction time length is longer than the standard extraction time length, adjusting the standard extraction time length;
Where Mb '=mb× [1+ (Vs-Vb)/Vs ], where Mb represents the set standard extraction duration, mb' represents the adjusted standard extraction duration, vs represents the calculated real-time extraction rate, and Vb represents the set standard extraction rate.
Further, the weight of the raw material to be detected after the squeezing treatment is obtained and is recorded as the weight of the initial raw material, and a standard infiltration amount, a first standard infiltration amount, a second standard infiltration amount and a standard infiltration amount range are determined according to the weight of the initial raw material, the water absorption strength, the current soaking time, the second preset time and the water content difference;
Wherein hb=zsxpb×ts/Tc2, hb 1=hb- Δs, hb 2=hb+Δs, hb represents the calculated standard infiltration amount, zs represents the initial raw material weight after the raw material to be detected is subjected to the pressing treatment, pb represents the water absorption strength of the mixed raw material, ts represents the current soaking time period, tc2 represents the set second preset time period, Δs represents the set water content difference value, hb1 represents the calculated first standard infiltration amount, hb2 represents the calculated second standard infiltration amount, and the first standard infiltration amount and the second standard infiltration amount constitute the standard infiltration amount range.
On the other hand, the invention also provides an ophthalmic traditional Chinese medicine preparation, based on the ophthalmic traditional Chinese medicine preparation and the extraction method of active ingredients thereof, wherein the preparation is prepared by extracting, concentrating and drying active ingredients of a Chinese herbal medicine raw material composition to prepare Chinese herbal medicine powder, and then dissolving the Chinese herbal medicine powder in hydrogen-rich water;
The Chinese herbal medicine raw material composition comprises, by weight, 10-15 parts of astragalus membranaceus, 5-10 parts of salvia miltiorrhiza, 5-10 parts of liquorice, 5-10 parts of fructus viticis, 5-10 parts of radix paeoniae alba, 3-5 parts of glutamine, 10-15 parts of medlar, 10-15 parts of semen cassiae, 3-5 parts of semen cuscutae, 5-10 parts of selfheal, 1-5 parts of mint and 1-5 parts of chrysanthemum.
Compared with the prior art, the method has the beneficial effects that the method fully absorbs the solvent from the dry medicinal materials by soaking the medicinal materials, promotes the release of the effective components in each medicinal material by increasing the temperature, automatically and intelligently monitors the soaking process, namely periodically grabs part of the medicinal materials to detect the water content, applies pressure to the medicinal materials, analyzes the quality of the extruded solution, namely detects the quality change of the medicinal materials from the dry state to the wet state, further analyzes the solvent content of the medicinal materials, and further, because the water absorption capacity of a specific medicinal material is limited, namely, the medicinal materials cannot continuously absorb more solvent when reaching the saturated state, the soaking process is detected in real time, the soaking efficiency is improved, meanwhile, the quality of the medicinal materials is ensured, the active components are prevented from being deactivated due to overhigh temperature by detecting the heating extraction process, and meanwhile, the intelligent calculation of the extraction rate is performed, so that the real-time performance and the extraction efficiency of the detection are improved.
Further, by setting a standard infiltration amount range, the real-time infiltration amount is compared with the standard infiltration amount range, so that the water absorption degree of the mixed raw materials is detected in real time, the larger the real-time infiltration amount value is, the larger the corresponding water absorption degree of the mixed raw materials is, if the real-time infiltration amount is judged to be within the standard infiltration amount range, the water content of the mixed raw materials reaches the preset standard, namely, all the medicinal materials are completely wetted, heating extraction is performed, and the release rate of effective substances in the medicinal materials is accelerated.
Further, when the real-time infiltration amount is determined to be smaller than the first standard infiltration amount, the mixed raw materials are still in a drier state at the moment, the water absorption degree of the mixed raw materials after the mixed raw materials are soaked by the soaking liquid is not reached, and the soaking time of the mixed raw materials is determined to determine whether the soaking liquid proportion needs to be adjusted, so that the soaking quality of the mixed raw materials is improved, and the soaking efficiency is improved.
Further, when the real-time infiltration amount is judged to be larger than the second standard infiltration amount, the water absorption capacity of the mixed raw materials is high, the soaking time is required to be adjusted in time, the phenomenon that the medicinal materials are soaked in the solvent for a long time and deactivated to weaken the medicinal effects of the medicinal materials is avoided, hidden microorganisms and molds in the medicinal materials diffuse more in the solvent to influence the safety of the medicinal materials, the medicinal materials are softened to reduce the quality, and meanwhile, the phenomenon that the medicinal materials absorb the solvent to reach a saturated state is ensured, so that the extraction effect is ensured.
Further, by judging the soaking time of the mixed raw materials still in a drier state, namely comparing the current soaking time with a preset time range, if the current soaking time is judged to not reach the preset soaking time, continuing to soak, if the current soaking time is judged to reach the preset soaking time, the mixed raw materials are incompletely soaked due to lower soaking liquid proportion, the soaking liquid proportion is required to be improved, and the increment is increased along with the increment of the difference between the current soaking time and the standard soaking time, so that the accuracy and instantaneity of adjustment are improved.
Further, by periodically acquiring an image of the solid-liquid mixture, characterizing the extraction state of the mixed raw materials according to the color change of the image, increasing the intelligence and instantaneity of detection, if the real-time brightness difference value is less than or equal to the standard brightness difference value, which indicates that the color change of the liquid of the solid-liquid mixture is not obvious, judging the color change rate of the liquid of the solid-liquid mixture to monitor the extraction process so as to determine whether the extraction process of the mixed raw materials is finished, and if the real-time brightness difference value is greater than the standard brightness difference value, indicating that the color change of the liquid of the solid-liquid mixture is obvious, which is due to the normal phenomenon caused by the fact that the chemical components in the mixed raw materials are dissolved in the ethanol solution and the dissolution speed is higher.
Further, the real-time extraction rate is compared with the standard extraction rate to characterize the color change, if the real-time extraction rate is judged to be smaller than the standard extraction rate, the color change of the solution is slow, the extraction rate is improved by properly changing the temperature, if the real-time extraction rate is judged to be larger than or equal to the standard extraction rate, the color change of the solution is fast, the extraction efficiency is high at the moment, and the detection intelligence and the instantaneity are improved by detecting the color change of the solution.
Further, under the condition that the color change of the solution is judged to be faster, the real-time extraction time length is judged according to the standard extraction time length to determine the extraction process, if the real-time extraction time length is judged to be longer than the standard extraction time length, the active ingredients in the mixed raw materials are still released, the release rate is higher, the preset standard extraction time length is required to be increased, so that the mixed raw materials are continuously dissolved in the solution, and the extraction efficiency and quality are improved.
Further, the standard infiltration amount range of the raw materials to be detected can be obtained through simple calculation, along with the increase of the soaking time, the water content of the raw materials to be detected also increases, until the raw materials to be detected reach a saturated state, the raw materials cannot absorb more solvents to reach the saturated state, the standard infiltration amount range tends to be constant, the water absorption amount of the medicinal materials in the soaking process is analyzed, the real-time performance of detection is improved, the soaking efficiency is improved, and the quality of the medicinal materials is guaranteed.
Drawings
FIG. 1 is a flow chart of an extraction method of an ophthalmic traditional Chinese medicine preparation and an active ingredient thereof according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of an intelligent leaching device according to an embodiment of the present invention;
FIG. 3 is a logic flow diagram of a soaking process according to an embodiment of the present invention;
FIG. 4 is a logic flow diagram of an extraction process according to an embodiment of the present invention.
Detailed Description
In order that the objects and advantages of the invention will become more apparent, the invention will be further described with reference to the following examples; it should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
Preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are merely for explaining the technical principles of the present invention, and are not intended to limit the scope of the present invention.
It should be noted that, in the description of the present invention, terms such as "upper," "lower," "left," "right," "inner," "outer," and the like indicate directions or positional relationships based on the directions or positional relationships shown in the drawings, which are merely for convenience of description, and do not indicate or imply that the apparatus or elements must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention.
Furthermore, it should be noted that, in the description of the present invention, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention can be understood by those skilled in the art according to the specific circumstances.
Referring to fig. 1 and 2, fig. 1 is a flowchart of an extraction method of an ophthalmic traditional Chinese medicine preparation and an active ingredient thereof according to an embodiment of the present invention, and fig. 2 is a schematic structural diagram of an intelligent leaching device 1 according to an embodiment of the present invention, which includes a grabbing mechanism 2, a camera mechanism 3, a humidity detection layer 4, a squeezing mechanism 5, a pressure sensor 6, and a control mechanism (not shown), wherein the humidity detection layer 4 is provided with a plurality of layers of filter screens for filtering a soaking solution generated by squeezing treatment; the pressure sensor 6 is used for detecting the weight of the raw material to be detected before and after the squeezing treatment; the control mechanism is used for acquiring the pressure detected by the pressure sensor 6 and calculating the weight difference before and after the squeezing treatment; the squeezing mechanism 5 is used for squeezing the raw material to be detected; the camera shooting mechanism 3 is used for acquiring a real-time solution image of the solution of the solid-liquid mixture in the intelligent leaching device 1; the grabbing mechanism 2 is used for grabbing the mixed raw materials in the intelligent leaching device 1 to the upper surface of the humidity detection layer 4; the invention provides an ophthalmic traditional Chinese medicine preparation and an extraction method of active ingredients thereof, which comprises,
Step S1, raw material treatment, namely respectively cutting, weighing and mixing the Chinese herbal medicine raw materials to form mixed raw materials, adding the mixed raw materials into an intelligent leaching device 1, adding a soaking solution into the intelligent leaching device 1 to form a solid-liquid mixture, and stirring and uniformly mixing the solid-liquid mixture;
Step S2, soaking, namely sampling and detecting the soaking process of the mixed raw materials, determining the real-time soaking amount and standard soaking amount range of the mixed raw materials according to the weight of the raw materials to be detected before and after squeezing, judging the current soaking time according to the preset time range when the real-time soaking amount is smaller than the first standard soaking amount, determining whether the preset feed-liquid ratio is judged, and adjusting the first preset time when the real-time soaking amount is larger than the second standard soaking amount;
Step S3, heating and extracting, namely heating and extracting the solid-liquid mixture when the real-time infiltration amount is judged to be within the standard infiltration amount range, obtaining a real-time solution image of the solution in the extracting process, calculating a real-time brightness difference value and a real-time extraction rate according to the real-time solution image, comparing the real-time extraction rate with the standard extraction rate when the real-time brightness difference value is judged to be smaller than or equal to the standard brightness difference value, adjusting the standard extraction time length when the real-time extraction rate is judged to be larger than or equal to the standard extraction rate and longer than the standard extraction time length, and adjusting the preset extraction temperature when the real-time brightness difference value is judged to be smaller than or equal to the standard brightness difference value and the real-time extraction rate is judged to be smaller than the standard extraction rate;
and S4, filtering the solid-liquid mixture in the preparation of the finished product, collecting filtrate, concentrating in vacuum until the solid content is 20% -50%, and drying at low temperature to form the Chinese herbal medicine powder.
The method has the advantages that the Chinese herbal medicine raw materials are soaked, the dry medicinal materials fully absorb solvents, the effective components in the medicinal materials are further promoted to be released through the rising temperature, automatic intelligent monitoring is carried out on the soaking process, namely, partial medicinal materials are periodically grabbed to carry out water content detection, pressure is applied to the medicinal materials, the quality of extruded solution is analyzed, namely, the quality change of the medicinal materials from a dry state to a wet state is detected, the solvent content of the medicinal materials is analyzed, and due to the fact that the water absorption capacity of a specific medicinal material is limited, namely, when the medicinal materials reach a saturated state, more solvents cannot be continuously absorbed, the soaking process is detected in real time, the soaking efficiency is improved, meanwhile, the quality of the medicinal materials is guaranteed, the fact that the temperature is too high is avoided to inactivate the active components is detected through the detection of the rising temperature extraction process, meanwhile, intelligent calculation is carried out on the extraction rate, and the real-time performance and the extraction efficiency of detection are improved.
Referring to FIG. 3, a logic flow diagram of a soaking process according to an embodiment of the present invention is shown;
Specifically, in the step S2, a standard infiltration amount range is set, the humidity of the mixed raw material is detected and determined at a plurality of sampling points, the raw material to be detected is taken from the solid-liquid mixture to the humidity detection layer 4 through the grabbing mechanism 2 to be squeezed, the weight value of the raw material to be detected before the squeezing process is obtained and recorded as a real-time infiltration amount, the real-time infiltration amount is compared with the standard infiltration amount range,
If the real-time infiltration amount is within the standard infiltration amount range, comparing the real-time brightness difference value with the standard brightness difference value to determine whether the extraction state of the mixed raw materials is normal;
If the real-time infiltration amount is not in the standard infiltration amount range, comparing the real-time infiltration amount with the first standard infiltration amount and the second standard infiltration amount respectively to determine whether to adjust the soaking state.
The standard infiltration amount range set in this embodiment represents the mass of the soak solution required to infiltrate the mixed raw material to saturation, and the set value is related to the water absorption degree of the mixed raw material, and is generally set to 1-5 times the weight of the mixed raw material, for example, if the gripping mechanism 2 grips 50 grams of the raw material to be detected at a time and weighs, the standard infiltration amount range may be set to 10-50 grams, that is, the weight of the raw material to be detected before and after pressing varies to 10-50 grams;
The sampling points are the moments of sampling the mixed raw materials at certain time intervals after the soaking is started, and the sampling judgment can be carried out once every 10 minutes.
And comparing the real-time infiltration amount with the standard infiltration amount range by setting the standard infiltration amount range so as to detect the water absorption degree of the mixed raw materials in real time, wherein the larger the real-time infiltration amount value is, the larger the corresponding water absorption degree of the mixed raw materials is, if the real-time infiltration amount is judged to be within the standard infiltration amount range, the water content of the mixed raw materials reaches the preset standard, namely, each medicinal material is completely wetted, heating and extracting are carried out, and the release rate of effective substances in the medicinal materials is accelerated.
Specifically, in the step S2, when it is determined that the real-time infiltration amount is not within the standard infiltration amount range, the real-time infiltration amount is compared with the first standard infiltration amount and the second standard infiltration amount, respectively,
If the real-time infiltration amount is smaller than the first standard infiltration amount, acquiring the current soaking time length of the mixed raw materials, and comparing the current soaking time length with a preset time length range to determine whether to adjust the first preset time length.
By judging that the real-time infiltration amount is smaller than the first standard infiltration amount, the mixed raw materials are still in a drier state at the moment, the water absorption degree of the mixed raw materials after the mixed raw materials are soaked by absorbing the soaking liquid is not reached, and the soaking time of the mixed raw materials is judged to determine whether the soaking liquid proportion needs to be adjusted or not, so that the soaking quality of the mixed raw materials is improved, and the soaking efficiency is improved.
Specifically, in the step S2, when it is determined that the real-time infiltration amount is not within the standard infiltration amount range, the real-time infiltration amount is compared with the first standard infiltration amount and the second standard infiltration amount, respectively,
If the real-time infiltration amount Hs is larger than the second standard infiltration amount Hb2, acquiring the current soaking time of the mixed raw material, and adjusting the first preset time length Tc1 to Tc1' =Tc1X [1- (Hb 2-Hs)/Hs ] according to the real-time infiltration amount Hs and the second standard infiltration amount Hb 2;
The first standard infiltration amount Hb1 and the second standard infiltration amount Hb2 form a standard infiltration amount range DeltaHb, hb1 is smaller than Hb2, the first preset duration Tc1 and the second preset duration Tc2 form a preset duration range DeltaTc, tc1 is smaller than Tc2, and the preset duration range is a fixed value;
The preset duration range set in this embodiment represents a time range required for completely soaking the mixed raw materials, is generally set between 1 and 2 hours depending on the kind and shape of the mixed raw materials, and is adaptively selected according to the air-drying degree and extraction requirement of the actual mixed raw materials;
Through judging that the real-time infiltration amount is greater than the second standard infiltration amount, the water absorption capacity of the mixed raw materials is strong at this moment, the soaking time is required to be adjusted in time, the medicinal materials are prevented from being soaked in the solvent for a long time, the inactivation phenomenon is generated, so that the medicinal effects of the medicinal materials are weakened, hidden microorganisms and molds in the medicinal materials are more diffused in the solvent, the safety of the medicinal materials is influenced, the medicinal materials are softened, the quality is reduced, and meanwhile, the condition that the medicinal materials absorb the solvent to reach a saturated state is ensured, so that the extraction effect is ensured.
Specifically, in the step S2, a preset feed-liquid ratio of the solid-liquid mixture is set, when it is determined that the real-time infiltration amount of the raw material to be detected is smaller than a first standard infiltration amount, a current soaking time length of the mixed raw material is obtained, the current soaking time length is compared with a preset time length range,
If the current soaking time length is less than or equal to the first preset time length, not adjusting the preset feed liquid ratio;
If the current soaking time period Ts is greater than the second preset time period Tc2, adjusting the preset feed liquid ratio Gc according to the current soaking time period Ts and the second preset time period Tc2 to be Gc' =Gc× [1+ (Ts-Tc2)/Ts ];
The preset feed liquid ratio set in this example represents the mass ratio of the mixed raw material to the soaking liquid, and is set to 1:8, adapting and adjusting according to the kind characteristics of the actual mixed raw materials, and in 1:7-1: the range between 10 is adaptively selected, and the soaking solution is ethanol solution;
The soaking time of the mixed raw materials still in a drier state is judged, namely, the current soaking time length is compared with the range of the preset time length, if the current soaking time length is judged to not reach the preset soaking time length, the soaking treatment is continued, if the current soaking time length is judged to reach the preset soaking time length, the mixed raw materials are incompletely soaked due to the fact that the soaking liquid proportion is low, the soaking liquid proportion is required to be improved, the increment is increased along with the increase of the difference between the current soaking time length and the standard soaking time length, and the accuracy and instantaneity of adjustment are improved.
Referring now to FIG. 4, a logic flow diagram of an extraction process according to an embodiment of the present invention is shown;
Specifically, in the step S3, a standard brightness difference of the solid-liquid mixture is set, when it is determined that the real-time infiltration amount of the mixed raw material is within the standard infiltration amount range, the solid-liquid mixture is heated, two real-time solution images corresponding to two end points of a preset detection period are acquired through the image capturing mechanism 3, a real-time brightness difference is calculated according to the two real-time solution images, the real-time brightness difference is compared with the standard brightness difference,
If the real-time brightness difference value is smaller than or equal to the standard brightness difference value, calculating the real-time extraction rate of the mixed raw materials, and comparing the real-time extraction rate with the standard extraction rate to determine whether to adjust the preset extraction temperature;
If the real-time brightness difference value is larger than the standard brightness difference value, judging that the extraction state of the mixed raw materials is normal.
The standard luminance difference value set in this embodiment indicates that the color of the solid-liquid mixture solution tends to be unchanged, that is, the color state of the solid-liquid mixture solution reaches the state that the chemical components in the mixed raw materials are completely dissolved in the ethanol solution, the set value is related to the types and components of the mixed raw materials, is theoretically approaching zero, is represented by gray values, is generally set between 0.1 and 1, and is adaptively selected according to the types of the actual mixed raw materials and the performance of the imaging mechanism 3; the preset detection period represents the set extraction detection time length of the mixed raw materials, is generally set between 3 minutes and 10 minutes, and is adaptively selected according to the actual extraction requirements;
The calculation of the real-time brightness difference value is obtained by respectively obtaining the gray values of two images to make difference, and the gray value of any image is the average gray value of each pixel point;
The method comprises the steps of periodically obtaining an image of a solid-liquid mixture, representing the extraction state of the mixed raw materials according to the color change representation of the image, increasing the detection intelligence and instantaneity, judging that the color change of the liquid of the solid-liquid mixture is not obvious if the real-time brightness difference value is smaller than or equal to the standard brightness difference value, judging the color change rate of the liquid of the solid-liquid mixture to monitor the extraction process, determining whether the extraction process of the mixed raw materials is finished or not, and judging that the color change of the liquid of the solid-liquid mixture is obvious if the real-time brightness difference value is larger than the standard brightness difference value, wherein the chemical components in the mixed raw materials are dissolved in an ethanol solution and the normal phenomenon is caused by the fact that the dissolution speed is high.
Specifically, in the step S3, a preset extraction temperature and a standard extraction rate for extracting the mixed raw material are set, when it is determined that the real-time brightness difference value is smaller than or equal to the standard brightness difference value, the real-time brightness difference value calculated in the last preset detection period is obtained, the real-time brightness difference value in the current preset detection period is subtracted by the real-time brightness difference value in the last preset detection period and divided by the preset detection period to obtain the real-time extraction rate of the mixed raw material, the real-time extraction rate is compared with the standard extraction rate,
If the real-time extraction rate Vs is smaller than the standard extraction rate Vb, the preset extraction temperature Qs is adjusted to be Qs' =qsx1+ (Vb-Vs)/Vs,
The calculation of the real-time brightness difference value is continued, the comparison of the real-time brightness difference value and the standard brightness difference value is carried out, and the extraction processing of the mixed raw materials is completed until the real-time brightness difference value is judged to be smaller than or equal to the standard brightness difference value again and the real-time extraction rate is smaller than the standard extraction rate;
If the real-time extraction rate is greater than or equal to the standard extraction rate, judging the real-time extraction time length according to the standard extraction time length to determine whether to adjust the standard extraction time length;
wherein, qs' is less than or equal to 50 ℃;
The preset extraction temperature set in this embodiment is set to 45 ℃, and since a proper temperature can promote dissolution of the active ingredients in the mixed raw materials, an increase in temperature is beneficial to the release rate of the active ingredients, however, an excessive temperature can cause inactivation of the active ingredients, so that the quality and efficiency of extraction are affected, therefore, the preset extraction temperature is generally set to 45-50 ℃ and is adaptively selected according to the actual medicinal material types; the set standard extraction rate represents the color change speed of the solution and can be set in the range of 0.4-1.1;
The real-time extraction rate is compared with the standard extraction rate to characterize the color change, if the real-time extraction rate is judged to be smaller than the standard extraction rate, the color change of the solution is slow, the extraction rate is improved by properly changing the temperature, if the real-time extraction rate is judged to be larger than or equal to the standard extraction rate, the color change of the solution is fast, the extraction efficiency is high at the moment, and the detection intelligence and the instantaneity are improved by detecting the color change of the solution.
Specifically, in the step S3, a standard extraction duration of the mixed raw material is set, when it is determined that the real-time extraction rate Vs is equal to or greater than the standard extraction rate Vb, a real-time extraction duration corresponding to the current time is obtained, and the real-time extraction duration is determined according to the standard extraction duration,
If the real-time extraction time length is less than or equal to the standard extraction time length, the standard extraction time length is not adjusted;
and if the real-time extraction time length is longer than the standard extraction time length, adjusting the standard extraction time length Mb to Mb' =Mb× [1+ (Vs-Vb)/Vs ].
The standard extraction duration set in this embodiment is 2 hours;
under the condition that the color change of the solution is judged to be faster, the real-time extraction time length is judged according to the standard extraction time length to determine the extraction process, if the real-time extraction time length is judged to be longer than the standard extraction time length, the active ingredients in the mixed raw materials are still released, the release rate is higher, the preset standard extraction time length is required to be increased, so that the mixed raw materials are continuously dissolved in the solution, and the extraction efficiency and quality are improved.
Specifically, the weight of the raw material to be detected after the squeezing treatment is obtained and is recorded as the weight of an initial raw material, and a standard infiltration amount, a first standard infiltration amount, a second standard infiltration amount and a standard infiltration amount range are determined according to the weight of the initial raw material, the water absorption strength, the current soaking time, the second preset time and the water content difference;
Wherein, hb=zsxpb×ts/Tc2, hb 1=hb- Δs, hb 2=hb+Δs, Δs=0.03×hb, hb represents the calculated standard infiltration amount, zs represents the initial raw material weight after the raw material to be detected is subjected to the pressing treatment, pb represents the water absorption strength of the mixed raw material, ts represents the current soaking time period, tc2 represents the set second preset time period, Δs represents the set water content difference value, hb1 represents the calculated first standard infiltration amount, hb2 represents the calculated second standard infiltration amount, and the first standard infiltration amount and the second standard infiltration amount constitute the standard infiltration amount range.
The water absorption strength set in this example was 2.5, the water content difference was an allowable error, and it was set to 3% of the standard wet out amount.
The standard infiltration amount range of the raw materials to be detected can be obtained through simple calculation, along with the increase of the soaking time, the water content of the raw materials to be detected also increases, until the raw materials to be detected reach a saturated state, the raw materials cannot absorb more solvents to reach the saturated state, the standard infiltration amount range tends to be constant, the water absorption amount of the medicinal materials in the soaking process is analyzed, the real-time performance of detection is improved, the soaking efficiency is improved, and the quality of the medicinal materials is guaranteed.
The invention also provides a Chinese herbal medicine raw material composition, which comprises 10-15 parts by weight of astragalus mongholicus, 5-10 parts by weight of salvia miltiorrhiza, 5-10 parts by weight of liquorice, 5-10 parts by weight of fructus viticis, 5-10 parts by weight of radix paeoniae alba, 3-5 parts by weight of glutamine, 10-15 parts by weight of medlar, 10-15 parts by weight of semen cassiae, 3-5 parts by weight of semen cuscutae, 5-10 parts by weight of selfheal, 1-5 parts by weight of mint and 1-5 parts by weight of chrysanthemum.
Example 1: the Chinese medicinal composition comprises, by weight, 10 parts of astragalus membranaceus, 10 parts of radix salviae miltiorrhizae, 5 parts of liquorice, 5 parts of fructus viticis, 5 parts of radix paeoniae alba, 3 parts of semen glutinosa, 12 parts of medlar, 13 parts of semen cassiae, 5 parts of semen cuscutae, 5 parts of selfheal, 5 parts of mint and 2 parts of chrysanthemum.
Example 2: the Chinese medicinal composition comprises 13 parts of astragalus root, 10 parts of red sage root, 8 parts of liquorice, 5 parts of fructus viticis, 5 parts of white peony root, 5 parts of cereal essence, 10 parts of medlar, 12 parts of semen cassiae, 3 parts of semen cuscutae, 3 parts of selfheal, 5 parts of mint and 2 parts of chrysanthemum according to the weight ratio.
The invention also provides an ophthalmic traditional Chinese medicine preparation, which is prepared by dissolving the prepared Chinese herbal medicine powder in hydrogen-rich water, and adding boric acid or sodium chloride to adjust the pH value to be between 6.5 and 7;
The Chinese herbal medicine preparation is used for testing by test groups, and the using method, the experimental data and the experimental results are as follows:
When the volunteer with visual fatigue is used, the head is gently bent backwards, and eyes look at the direction of the top of the head. The food finger pulls down the lower eyelid to expose the conjunctival sac; dripping the Chinese herbal medicine preparation into conjunctival sac 1-2 cm above eyes, and gently closing eyes for 5 min; the preparation is used for 2 times a day for one week.
Adult volunteers with visual fatigue were selected by the test population, ranging in age from 18 to 65 years, with unlimited sexuality. The trial was randomized into two groups, a trial group and a control group of 60 persons each.
Test group: when the volunteer with visual fatigue is used, the head is gently bent backwards, and eyes look at the direction of the top of the head. The food is to pull down the lower eyelid to expose the conjunctival sac. And (3) dripping hydrogen-rich water into conjunctival sac 1-2 cm above the eyes, and gently closing the eyes for 5 minutes. The preparation is used for 2 times a day for one week.
Control group: the control group did not use any product.
Before the test starts, recording the fatigue state, dry eyes and red blood streak of each patient; after the end of the test period, each of the experimenters' sensations were evaluated, including the features described above; finally, investigation of the improved feeling of the patient is carried out; any adverse events associated with the use of the product, such as allergic reactions or skin irritation, were monitored during the test.
The experimental results are shown in table 1 and table 2, wherein table 1 is the test index and result of the Chinese herbal medicine preparation prepared by the medicinal material formulation of the embodiment 1 of the present invention, and table 2 is the test index and result of the Chinese herbal medicine preparation prepared by the medicinal material formulation of the embodiment 2 of the present invention;
TABLE 1
| Index (I) | Test group | Control group |
| Fatigue relief | 89.2％ | No improvement |
| Condition of red blood streak | 88.3％ | No improvement |
| Dry eye astringents | 90.8％ | No improvement |
| Patient satisfaction scoring | 90.5％ | No improvement |
| Allergic reactions or skin irritation | Without any means for | Without any means for |
TABLE 2
| Index (I) | Test group | Control group |
| Fatigue relief | 91.2％ | No improvement |
| Condition of red blood streak | 89.3％ | No improvement |
| Dry eye astringents | 92.8％ | No improvement |
| Patient satisfaction scoring | 93.6％ | No improvement |
| Allergic reactions or skin irritation | Without any means for | Without any means for |
The Chinese herbal medicine preparation prepared in the embodiment achieves the effect of preventing and delaying the vision increase by relieving the eyestrain and the dry eyes, provides experimental data for proving the curative effect of the Chinese herbal medicine formula capable of relieving the eyestrain and the dry eyes, and provides medicinal material comparison screening experiments.
Thus far, the technical solution of the present invention has been described in connection with the preferred embodiments shown in the drawings, but it is easily understood by those skilled in the art that the scope of protection of the present invention is not limited to these specific embodiments. Equivalent modifications and substitutions for related technical features may be made by those skilled in the art without departing from the principles of the present invention, and such modifications and substitutions will be within the scope of the present invention.
The foregoing description is only of the preferred embodiments of the invention and is not intended to limit the invention; various modifications and variations of the present invention will be apparent to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. An ophthalmic traditional Chinese medicine preparation and an extraction method of active ingredients thereof are characterized in that the preparation comprises,
Step S1, raw material treatment, namely respectively cutting, weighing and mixing the Chinese herbal medicine raw materials to form mixed raw materials, adding the mixed raw materials into an intelligent leaching device, adding a soaking solution into the intelligent leaching device to form a solid-liquid mixture, and stirring and uniformly mixing the solid-liquid mixture;
Step S2, soaking, namely sampling and detecting the soaking process of the mixed raw materials, determining the real-time soaking amount and standard soaking amount range of the mixed raw materials according to the weight of the raw materials to be detected before and after squeezing, judging the current soaking time according to the preset time range when the real-time soaking amount is smaller than the first standard soaking amount, determining whether the preset feed-liquid ratio is judged, and adjusting the first preset time when the real-time soaking amount is larger than the second standard soaking amount;
Step S3, heating and extracting, namely heating and extracting the solid-liquid mixture when the real-time infiltration amount is judged to be within the standard infiltration amount range, obtaining a real-time solution image of the solution in the extracting process, calculating a real-time brightness difference value and a real-time extraction rate according to the real-time solution image, comparing the real-time extraction rate with the standard extraction rate when the real-time brightness difference value is judged to be smaller than or equal to the standard brightness difference value, adjusting the standard extraction time length when the real-time extraction rate is judged to be larger than or equal to the standard extraction rate and longer than the standard extraction time length, and adjusting the preset extraction temperature when the real-time brightness difference value is judged to be smaller than or equal to the standard brightness difference value and the real-time extraction rate is judged to be smaller than the standard extraction rate;
S4, preparing a finished product, filtering the solid-liquid mixture, collecting filtrate, concentrating and drying to form Chinese herbal medicine powder;
The first preset duration is the minimum value of a preset duration range, and the preset duration range is a fixed value; the first standard infiltration amount is the minimum value of the standard infiltration amount range, and the second standard infiltration amount is the maximum value of the standard infiltration amount range.
2. The method for extracting an ophthalmic traditional Chinese medicine preparation and an active ingredient thereof according to claim 1, wherein in the step S2, a standard infiltration amount range is set, the humidity of the mixed raw material is detected and judged at a plurality of sampling points, the raw material to be detected is taken from the solid-liquid mixture to a humidity detection layer through a grabbing mechanism to be squeezed, the weight value of the raw material to be detected before the squeezing treatment is obtained and recorded as a real-time infiltration amount, the real-time infiltration amount is compared with the standard infiltration amount range,
If the real-time infiltration amount is within the standard infiltration amount range, comparing the real-time brightness difference value with the standard brightness difference value to determine whether the extraction state of the mixed raw materials is normal;
If the real-time infiltration amount is not in the standard infiltration amount range, comparing the real-time infiltration amount with the first standard infiltration amount and the second standard infiltration amount respectively to determine whether to adjust the soaking state.
3. The method for extracting an ophthalmic traditional Chinese medicine preparation and an active ingredient thereof according to claim 2, wherein in the step S2, when the real-time infiltration amount is determined not to be within the standard infiltration amount range, the real-time infiltration amount is compared with the first standard infiltration amount and the second standard infiltration amount, respectively,
If the real-time infiltration amount is smaller than the first standard infiltration amount, acquiring the current soaking time length of the mixed raw materials, and comparing the current soaking time length with a preset time length range to determine whether to adjust the first preset time length.
4. The method for extracting an ophthalmic traditional Chinese medicine preparation and an active ingredient thereof according to claim 2, wherein in the step S2, when the real-time infiltration amount is determined not to be within the standard infiltration amount range, the real-time infiltration amount is compared with the first standard infiltration amount and the second standard infiltration amount, respectively,
If the real-time infiltration amount is larger than the second standard infiltration amount, acquiring the current soaking time of the mixed raw materials, and adjusting the first preset time according to the real-time infiltration amount and the second standard infiltration amount;
Wherein Tc1 '=tc1× [1- (Hb 2-Hs)/Hs ], tc1 represents a set first preset duration, tc1' represents an adjusted first preset duration, hb2 represents a set second standard infiltration amount, and Hs represents a calculated real-time infiltration amount of the raw material to be detected.
5. The method for extracting an ophthalmic traditional Chinese medicine preparation and an active ingredient thereof according to claim 3, wherein in the step S2, a preset feed-liquid ratio of the solid-liquid mixture is set, when the real-time infiltration amount of the raw material to be detected is determined to be smaller than a first standard infiltration amount, a current soaking time length of the mixed raw material is obtained, the current soaking time length is compared with a preset time length range,
If the current soaking time length is longer than the second preset time length, adjusting the preset feed liquid ratio according to the current soaking time length and the second preset time length;
Wherein Gc '=gc× [1+ (Ts-Tc 2)/Ts ], gc represents a set preset feed-to-liquid ratio, gc' represents an adjusted preset feed-to-liquid ratio, ts represents a current soaking period of the mixed raw material, tc2 represents a set second preset period of time, the preset period of time range is a fixed value, and the second preset period of time is a maximum value of the preset period of time range and varies with the first preset period of time.
6. The method according to claim 2, wherein when the real-time infiltration amount of the mixed raw materials is determined to be within the standard infiltration amount range, the solid-liquid mixture is heated, two real-time solution images corresponding to two end points of a preset detection period are obtained through the image capturing mechanism, a real-time luminance difference value is calculated according to the two real-time solution images, the real-time luminance difference value is compared with the standard luminance difference value, when the real-time luminance difference value is determined to be less than or equal to the standard luminance difference value, a real-time extraction rate of the mixed raw materials is calculated, and the real-time extraction rate is compared with the standard extraction rate to determine whether the preset extraction temperature is adjusted.
7. The method for extracting an ophthalmic traditional Chinese medicine preparation and an active ingredient thereof according to claim 6, wherein when it is determined that the real-time luminance difference value is less than or equal to the standard luminance difference value, the real-time luminance difference value calculated in the last preset detection period is obtained, the real-time luminance difference value of the current preset detection period is subtracted by the real-time luminance difference value of the last preset detection period and divided by the preset detection period to obtain the real-time extraction rate of the mixed raw material, the real-time extraction rate is compared with the standard extraction rate,
If the real-time extraction rate is greater than or equal to the standard extraction rate, judging the real-time extraction time length according to the standard extraction time length to determine whether to adjust the standard extraction time length;
If the real-time extraction rate is smaller than the standard extraction rate, adjusting the preset extraction temperature, continuing to calculate the real-time brightness difference value, and comparing the real-time brightness difference value with the standard brightness difference value to judge the real-time brightness difference value until the real-time brightness difference value is smaller than or equal to the standard brightness difference value again, and finishing the extraction treatment of the mixed raw materials when the real-time extraction rate is smaller than the standard extraction rate;
Wherein Qs '=qs× [1+ (Vb-Vs)/Vs ], qs represents a set preset extraction temperature, qs' represents an adjusted preset extraction temperature, vb represents a set standard extraction rate, and Vs represents a calculated real-time extraction rate.
8. The method according to claim 7, wherein in the step S3, a standard extraction time length of the mixed raw materials is set, and when the real-time extraction rate is determined to be equal to or higher than the standard extraction rate, the real-time extraction time length corresponding to the current time is obtained, and the real-time extraction time length is determined based on the standard extraction time length,
If the real-time extraction time length is longer than the standard extraction time length, adjusting the standard extraction time length;
Where Mb '=mb× [1+ (Vs-Vb)/Vs ], where Mb represents the set standard extraction duration, mb' represents the adjusted standard extraction duration, vs represents the calculated real-time extraction rate, and Vb represents the set standard extraction rate.
9. The method for extracting an ophthalmic traditional Chinese medicine preparation and an active ingredient thereof according to claim 2, wherein the weight of the raw material to be detected after the squeezing treatment is obtained and is recorded as an initial raw material weight, and a standard infiltration amount, a first standard infiltration amount, a second standard infiltration amount and a standard infiltration amount range are determined according to the initial raw material weight, the water absorption strength, the current soaking time, the second preset time and a water content difference value;
Wherein hb=zsxpb×ts/Tc2, hb 1=hb- Δs, hb 2=hb+Δs, hb represents the calculated standard infiltration amount, zs represents the initial raw material weight after the raw material to be detected is subjected to the pressing treatment, pb represents the water absorption strength of the mixed raw material, ts represents the current soaking time period, tc2 represents the set second preset time period, Δs represents the set water content difference value, hb1 represents the calculated first standard infiltration amount, hb2 represents the calculated second standard infiltration amount, and the first standard infiltration amount and the second standard infiltration amount constitute the standard infiltration amount range.
10. An ophthalmic traditional Chinese medicine preparation based on the extraction method of the ophthalmic traditional Chinese medicine preparation and the active ingredients thereof according to the claims 1-9, which is characterized in that the preparation is prepared by extracting, concentrating and drying the active ingredients of a Chinese herbal medicine raw material composition to prepare Chinese herbal medicine powder, and then dissolving the Chinese herbal medicine powder in hydrogen-rich water;
The Chinese herbal medicine raw material composition comprises, by weight, 10-15 parts of astragalus membranaceus, 5-10 parts of salvia miltiorrhiza, 5-10 parts of liquorice, 5-10 parts of fructus viticis, 5-10 parts of radix paeoniae alba, 3-5 parts of glutamine, 10-15 parts of medlar, 10-15 parts of semen cassiae, 3-5 parts of semen cuscutae, 5-10 parts of selfheal, 1-5 parts of mint and 1-5 parts of chrysanthemum.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393496A (en) * | 2006-03-31 | 2013-11-20 | 玛提治疗有限公司 | Nasolacrimal drainage system implants for drug therapy |
| CN109078085A (en) * | 2018-09-19 | 2018-12-25 | 山东景仲生物科技有限公司 | A kind of preparation method of pharmaceutical hydrogel that treating the dry and astringent inflammation of asthenopia |
| CN115024977A (en) * | 2022-04-19 | 2022-09-09 | 南通汉药中医医院有限公司 | Quality control method and quality control equipment for Chinese medicinal paste |
| WO2023016259A1 (en) * | 2021-08-11 | 2023-02-16 | 苏州泽达兴邦医药科技有限公司 | Data mining-based quality control method for traditional chinese medicine extraction process |
| CN115957275A (en) * | 2022-12-08 | 2023-04-14 | 广东邓庭全十三脉血液研究院 | Traditional Chinese medicine eye drop for eye care and preparation method thereof |
| CN117092304A (en) * | 2023-08-25 | 2023-11-21 | 南通森萱药业有限公司 | Full-flow monitoring analysis management system for pharmaceutical intermediate production process |
-
2024
- 2024-03-15 CN CN202410300647.XA patent/CN118190718A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393496A (en) * | 2006-03-31 | 2013-11-20 | 玛提治疗有限公司 | Nasolacrimal drainage system implants for drug therapy |
| CN109078085A (en) * | 2018-09-19 | 2018-12-25 | 山东景仲生物科技有限公司 | A kind of preparation method of pharmaceutical hydrogel that treating the dry and astringent inflammation of asthenopia |
| WO2023016259A1 (en) * | 2021-08-11 | 2023-02-16 | 苏州泽达兴邦医药科技有限公司 | Data mining-based quality control method for traditional chinese medicine extraction process |
| CN115024977A (en) * | 2022-04-19 | 2022-09-09 | 南通汉药中医医院有限公司 | Quality control method and quality control equipment for Chinese medicinal paste |
| CN115957275A (en) * | 2022-12-08 | 2023-04-14 | 广东邓庭全十三脉血液研究院 | Traditional Chinese medicine eye drop for eye care and preparation method thereof |
| CN117092304A (en) * | 2023-08-25 | 2023-11-21 | 南通森萱药业有限公司 | Full-flow monitoring analysis management system for pharmaceutical intermediate production process |
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