CN118156118A - Gas-phase ion reaction device, mass spectrometer and detection method of nonpolar compound - Google Patents
Gas-phase ion reaction device, mass spectrometer and detection method of nonpolar compound Download PDFInfo
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- 229910021645 metal ion Inorganic materials 0.000 claims abstract description 54
- 238000005336 cracking Methods 0.000 claims abstract description 45
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- 238000000034 method Methods 0.000 claims description 21
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- 239000012159 carrier gas Substances 0.000 claims description 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 7
- 239000011261 inert gas Substances 0.000 claims description 7
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 6
- 230000037427 ion transport Effects 0.000 claims description 6
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 229910052786 argon Inorganic materials 0.000 claims description 3
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- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 9
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Abstract
The invention discloses a gas-phase ion reaction device, a mass spectrometer and a detection method of nonpolar compounds, wherein the gas-phase ion reaction device comprises an ion source, a sealed cavity, an ion transmission pipe and an ion cracking device which are connected in sequence; and a sample inlet to be tested is arranged on the sealing cavity. The gas-phase ion reaction device provided by the invention can specifically ionize nonpolar compounds difficult to ionize, can generate metal ions with stronger reactivity through collision and cleavage, and can generate new compound ions through gas-phase ion-molecule reaction of the metal ions with stronger reactivity and nonpolar gaseous compounds in the ion cleavage device, so as to realize soft ionization of the nonpolar gaseous compounds, and the compound ions can be detected through mass spectrometry.
Description
Technical Field
The invention relates to the technical field of mass spectrometry detection, in particular to a gas phase ion reaction device, a mass spectrometer and a detection method of nonpolar compounds.
Background
The mass spectrometry technology is widely applied to various analysis fields due to the characteristics of high sensitivity, low detection limit, small sample consumption, high throughput, high detection speed and the like. The ion source is used as an important component of a mass spectrometer and is used for ionizing a sample to be analyzed to obtain ions with sample information. With the continuous development of mass spectrometry, ion sources are becoming diverse, and electron bombardment ionization (EI) sources, electrospray ion (ESI) sources, atmospheric Pressure Chemical Ionization (APCI) sources, matrix Assisted Laser Desorption Ionization (MALDI) sources, and the like are more common at present. The analytes that the different ion sources should handle are different, as shown in fig. 1 are polar and molecular weight distribution of several classes of compounds that are suitable for analysis by common ion sources. ESI sources are generally suitable for analysis of polar materials as the most widely used ion source in liquid chromatography-mass spectrometry (LC-MS) and are primarily directed to liquid samples. If moderately polar materials are to be analyzed, APCI sources are required, whereas non-polar materials (such as alkanes) are often ionized using EI sources provided in gas chromatography-mass spectrometry (GC-MS). Different ion sources have certain limitations in application range, and besides expanding the universality of the ion sources, developing an ionization method with specificity for specific analytes has very important practical value.
Accordingly, the prior art is still in need of improvement and development.
Disclosure of Invention
In view of the above-mentioned shortcomings of the prior art, an object of the present invention is to provide a gas phase ion reaction apparatus, a mass spectrometer and a method for detecting a nonpolar compound, which aim to develop an ionization method specific to a nonpolar compound difficult to ionize, and further to detect the nonpolar compound.
The technical scheme of the invention is as follows:
The invention provides a gas-phase ion reaction device, which comprises an ion source, a sealed cavity, an ion transmission pipe and an ion cracking device which are connected in sequence;
And a sample inlet to be tested is arranged on the sealing cavity.
Optionally, the ion source is an ESI source, APCI source, glow discharge source, or photoionization source.
In a second aspect of the present invention, there is provided a mass spectrometer comprising a gas phase ion reaction apparatus as described above according to the present invention, further comprising:
The mass analyzer is connected with the ion cracking device;
And the detector is connected with the mass analyzer.
In a third aspect of the present invention, there is provided a method of detecting a non-polar compound, wherein the method of detecting a non-polar compound using a mass spectrometer as described above of the present invention comprises the steps of:
providing a metal compound solution and a nonpolar compound to be detected, wherein the nonpolar compound to be detected is a nonpolar first gaseous compound;
passing the metal compound solution through an ion source to produce complex ions containing metal elements or cluster ions containing metal elements;
Introducing the complex ions containing metal elements or cluster ions containing metal elements into a sealed cavity, and then introducing the nonpolar first gaseous compound and carrier gas into the sealed cavity from a sample inlet to be tested to form a mixed gas;
Transmitting the mixed gas into an ion cracking device by utilizing an ion transmission pipe, wherein compound ions containing metal elements or cluster ions containing metal elements in the mixed gas collide with carrier gas for cracking to generate metal ions, and the metal ions react with nonpolar first gaseous compounds to obtain compound ions;
and detecting the composite ions by a mass analyzer and a detector, and identifying the nonpolar compound to be detected by the detection result.
In a fourth aspect of the present invention, there is provided a method of detecting a non-polar compound, wherein the method of detecting a non-polar compound using a mass spectrometer as described above of the present invention comprises the steps of:
Providing a metal compound solution and a nonpolar compound to be detected, wherein the nonpolar compound to be detected is a nonpolar volatile liquid compound, and the nonpolar volatile liquid compound volatilizes to generate a nonpolar second gaseous compound;
passing the metal compound solution through an ion source to produce complex ions containing metal elements or cluster ions containing metal elements;
Introducing the complex ions containing metal elements or cluster ions containing metal elements into a sealed cavity, then placing the nonpolar volatile liquid compound at an inlet of a sample to be tested, and enabling nonpolar second gaseous compound generated by volatilization of the nonpolar volatile liquid compound and a carrier to enter the sealed cavity from the inlet of the sample to be tested to form a mixed gas;
Transmitting the mixed gas into an ion cracking device by utilizing an ion transmission pipe, wherein compound ions containing metal elements or cluster ions containing metal elements in the mixed gas collide with carrier gas for cracking to generate metal ions, and the metal ions react with nonpolar second gaseous compounds to obtain compound ions;
and detecting the composite ions by a mass analyzer and a detector, and identifying the nonpolar compound to be detected by the detection result.
Optionally, the air pressure range of the ion cracking device is set to be 10 -1～103 Pa.
Optionally, the voltage difference between the ion transmission tube and the ion cracking device is set to be-200V, and the voltage difference between the ion transmission tube and the ion cracking device is not set to be 0.
Optionally, the carrier is an inert gas.
Optionally, the inert gas includes one of nitrogen and argon.
Optionally, the metal compound solution includes an inorganic metal salt solution or an organic metal compound solution.
The beneficial effects are that: the gas-phase ion reaction device provided by the invention can specifically ionize nonpolar compounds difficult to ionize, can generate metal ions with stronger reactivity through collision and cleavage, and can generate new compound ions through gas-phase ion-molecule reaction of the metal ions with stronger reactivity and nonpolar gaseous compounds in the ion cleavage device, so as to realize soft ionization of the nonpolar gaseous compounds, and the compound ions can be detected through mass spectrometry.
Drawings
FIG. 1 shows the polarity and molecular weight distribution of compounds suitable for analysis by several common ion sources of the prior art.
Fig. 2 is a schematic diagram of a mass spectrometer according to an embodiment of the present invention.
FIG. 3 is a mass spectrum of the product after ionization of the PdCl 2 solution by ESI source.
FIG. 4 is a mass spectrum of the product of PdCl 2 after passing through the mass spectrometer of example 1 of the present invention.
Fig. 5 is a mass spectrum obtained by sampling n-heptane into the mass spectrometer of example 1 of the present invention.
Detailed Description
The present invention provides a gas phase ion reaction apparatus, a mass spectrometer and a method for detecting a nonpolar compound, and for the purpose, technical scheme and effect of the present invention to be more clear and definite, the present invention will be further described in detail below. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
The embodiment of the invention provides a gas-phase ion reaction device, which is shown in fig. 2, and comprises an ion source 1, a sealed cavity 2, an ion transmission pipe 3 and an ion cracking device 4 which are connected in sequence; the sealed cavity 2 is provided with a sample inlet 21 to be tested.
Some nonpolar gaseous compounds are difficult to ionize directly and cannot be detected by mass spectrometry, metal ions with stronger reactivity can be generated by collision and cleavage by using the gas-phase ion reaction device provided by the embodiment, and new composite ions are generated by gas-phase ion-molecule reaction of the metal ions with stronger reactivity and the nonpolar gaseous compounds in the ion cleavage device, so that soft ionization of the nonpolar gaseous compounds is realized, and the composite ions can be detected by mass spectrometry later.
In this embodiment, the ion source is used to generate a complex ion containing a metal element or a cluster ion containing a metal element (for example, a complex ion or charged droplet composed of a metal ion and a solvent molecule) from a metal compound solution, and the sample inlet is used for introducing a gaseous sample containing the sample.
The sealed cavity is used for controlling the composition of substances participating in the reaction, especially reducing the participation of air, and compared with other open ion sources, the sealed ion source cavity can avoid the participation of a large amount of air into the instrument to participate in the reaction, and reduce the interference on gas-phase ion-molecule reaction.
The ion transport tube is one of the components that control ion fragmentation. The ion cracking device is another component for controlling ion cracking, and the ion cracking is initiated and controlled by the voltage difference between the ion cracking device and the ion transmission pipe, meanwhile, the ion cracking device is also a place where metal ions are generated and gas-phase ion-molecule reactions occur, namely, the ion cracking device is used for generating metal ions and is a place where the gas-phase ion-molecule reactions occur, and the metal ions are generated by collision cracking and can immediately participate in the reactions with nonpolar gaseous compounds to be detected. The generation of metal ions and the gas-phase ion-molecule reaction are realized in the same device (ion cracking device), so that the intermediate link is shortened, and the interference and ion loss are reduced. The metal ions in the solution often exist in the form of a compound or cluster, and are difficult to obtain metal ions (namely pure metal ions) when ionized by using technologies such as electrospray, etc., generally, the compound ions containing metal elements or the cluster ions containing metal elements can be obtained, and the compound ions containing metal elements or the cluster ions containing metal elements have low reactivity and cannot react with nonpolar gaseous compounds to be detected in a gas phase ion-molecule way. The complex ions containing metal elements or cluster ions containing metal elements can be crashed in an ion cracking device in a collision cracking mode, so that metal ions with higher reactivity (which can generate gas-phase ion-molecule reaction with nonpolar gaseous compounds to be detected) are generated, and further subsequent gas-phase ion-molecule reaction can be performed.
Specifically, passing a metal compound solution through an ion source to generate complex ions containing metal elements or cluster ions containing metal elements (such as complex ions or charged droplets formed by metal ions and solvent molecules, etc.); introducing the complex ions containing metal elements or cluster ions containing metal elements into a sealed cavity, and then introducing a nonpolar gas compound and carrier gas into the sealed cavity from a sample inlet to be tested to form a mixed gas; and the mixed gas is transmitted to an ion cracking device by utilizing an ion transmission pipe, and the composite ions containing metal elements or cluster ions containing metal elements in the mixed gas are collided and cracked with carrier gas to generate metal ions (high in activity and easy to identify), and the metal ions react with nonpolar compounds to obtain composite ions, so that the soft ionization of the nonpolar compounds is realized.
In addition, although the EI source can ionize nonpolar compounds (such as alkanes), the EI source ionizes gas molecules to be detected by high-energy electron bombardment, and the electron energy is high (generally 70 eV), and the process is accompanied with fragmentation of the gas molecules to be detected, so that a mass spectrum has a plurality of fragment ion peaks, which is unfavorable for spectrum analysis. In the embodiment, the metal ions are used for reacting with the gaseous sample to be detected, the ionization of the sample is mainly carried out based on ion-molecule reaction, the process belongs to a soft ionization process, the fragmentation of the ions is generally not initiated, the generated product ions can ensure the complete molecular structure, and the spectral peak composition is simpler. In the embodiment of the invention, although the composite ions containing metal elements or the cluster ions containing metal elements are accelerated to generate metal ions, the energy can reach about 100eV, but the energy is greatly lost in the process of generating the metal ions by collision of the composite ions containing metal elements or the cluster ions containing metal elements with carrier gas molecules, so that the kinetic energy of the finally generated metal ions is lower, and the subsequent ion-molecule reaction caused by collision of the finally generated metal ions with the gas to be detected can not cause structural fragmentation of gas molecules.
In some embodiments, the ion source is an ESI source, APCI source, glow discharge source, or photoionization source.
The embodiment of the invention also provides a mass spectrometer, which comprises the gas-phase ion reaction device disclosed by the embodiment of the invention, and further comprises:
The mass analyzer is connected with the ion cracking device;
And the detector is connected with the mass analyzer.
That is, as shown in fig. 2, the mass spectrometer includes an ion source 1, a sealed chamber 2, an ion transfer tube 3, an ion fragmentation device 4, a mass analyzer 5, and a detector 6, which are connected in this order.
Wherein the ion source may be an ESI source, an APCI source, a glow discharge source, or a photoionization source. The ion beam splitter includes an ion lens assembly, and the invention is not limited to the specific structure. In this embodiment, the ion source, ion transport tube, ion fragmentation device, mass analyzer, and detector are all commercially available. The ion transmission tube, the mass analyzer and the detector can be specifically provided with accessories on a Q-Exactive mass spectrometer of the Siemens femto company, and the ion cracking device can be composed of ion lenses.
The EI source is generally configured only in GC-MS for analysis of the nonpolar compound; an ESI source configured in conventional LC-MS-like mass spectrometry is used for analysis of strongly polar compounds. The mass spectrometer provided by the embodiment of the invention not only can be used for detecting nonpolar compounds (by reacting with metal ions in a cracking device to form composite ions so as to further realize the detection of nonpolar compounds), but also can be used for detecting polar compounds (an EIS source in the mass spectrometer can ionize polar compounds to realize the detection of polar compounds), so that the application range of the ESI source is enlarged, and the switching of an ion source and mass spectrometry equipment is avoided. Meanwhile, the embodiment of the invention realizes the generation of metal ions and the gas-phase ion-molecule reaction in the same device (ion cracking device), shortens the intermediate link and reduces the interference and the ion loss.
The embodiment of the invention also provides a detection method of the nonpolar compound, wherein the detection method of the nonpolar compound by adopting the mass spectrometer disclosed by the embodiment of the invention comprises the following steps:
S11, providing a metal compound solution and a nonpolar compound to be detected, wherein the nonpolar compound to be detected is a nonpolar first gaseous compound;
s12, passing the metal compound solution through an ion source to generate complex ions containing metal elements or cluster ions containing metal elements;
S13, introducing the complex ions containing the metal elements or the cluster ions containing the metal elements into a sealed cavity, and then introducing the nonpolar first gaseous compound and carrier gas into the sealed cavity from a sample inlet to be tested to form a mixed gas;
S14, transmitting the mixed gas into an ion cracking device (loaded with direct-current voltage) by utilizing an ion transmission pipe (loaded with direct-current voltage), wherein compound ions containing metal elements or cluster ions containing metal elements in the mixed gas collide with carrier gas for cracking to generate metal ions, and the metal ions react with nonpolar first gaseous compounds to obtain compound ions;
s15, detecting the composite ions through a mass analyzer and a detector, and identifying the nonpolar compound to be detected through a detection result.
The embodiment of the invention also provides a detection method of the nonpolar compound, wherein the detection method of the nonpolar compound by adopting the mass spectrometer disclosed by the embodiment of the invention comprises the following steps:
S21, providing a metal compound solution and a nonpolar compound to be detected, wherein the nonpolar compound to be detected is a nonpolar volatile liquid compound, and the nonpolar volatile liquid compound volatilizes to generate a nonpolar second gaseous compound;
S22, passing the metal compound solution through an ion source to generate complex ions containing metal elements or cluster ions containing metal elements;
S23, introducing the complex ions containing metal elements or cluster ions containing metal elements into a sealed cavity, then placing the nonpolar volatile liquid compound at an inlet of a sample to be tested, and enabling a nonpolar second gaseous compound generated by volatilizing the nonpolar volatile liquid compound and a carrier to enter the sealed cavity from the inlet of the sample to be tested to form a mixed gas;
S24, transmitting the mixed gas into an ion cracking device (loaded with direct-current voltage) by utilizing an ion transmission pipe (loaded with direct-current voltage), wherein compound ions containing metal elements or cluster ions containing metal elements in the mixed gas collide with carrier gas for cracking to generate metal ions, and the metal ions react with nonpolar second gaseous compounds to obtain compound ions;
S25, detecting the composite ions through a mass analyzer and a detector, and identifying the nonpolar compound to be detected through a detection result.
In this embodiment, metal ions are generated through an ion transmission tube and an ion splitting device in the mass spectrometer, and composite ions (containing metal elements and facilitating analysis of a mass spectrogram and understanding of gas phase reactions) are generated through reaction of the metal ions and substances to be detected, so that detection of nonpolar compounds (nonpolar gaseous compounds and nonpolar volatile liquid compounds) is realized.
In the embodiment of the invention, the metal compound solution is used as a raw material, the metal ions are generated by using a cracking device, the metal ions have special reactivity and can selectively react with some gaseous compounds to generate new compound ions, and some nonpolar compounds (such as alkane) which are difficult to ionize are analyzed by using the method. In addition, the formed composite ions contain metal ions, so that the generated composite ions can be identified by utilizing the special isotope distribution of the metal ions, and the analysis difficulty of a spectrogram is reduced. Further, the metal ions are the final products of the cracking, even if the energy is increased, the metal ions are not cracked any more, namely, the product ions generated by the cracking are mainly metal ions, if other organic molecules are selected as raw materials, the cracking degree during the cracking can be increased along with the increase of the cracking energy, some rearrangement reactions and the like can also occur, and stable and controllable fragment ions are difficult to generate so as to utilize the control and recognition of the subsequent ion-molecule reaction.
Because metal ions in the solution often exist in a complex or cluster form, pure metal ions cannot be generated by directly utilizing an ESI source plasma source, specifically, pdCl 2 solution is introduced by self suction through a spray pipe, voltage (2-5 KV) is applied to the spray pipe to ionize the solution, a mass spectrum (shown in fig. 3) is observed, no ion peak of Pd is visible, which indicates that the direct ionization PdCl 2 solution cannot form high-strength Pd ions, some impurity interfering ions are mainly generated, and Pd ions are "hidden" in some complexes or ion clusters after ESI, so that the metal ions are required to be generated by pyrolysis, and the metal ions are released from the complexes or ion clusters through the pyrolysis process.
In some embodiments, the gas pressure range of the ion beam splitting device is set to 10 -1～103 Pa. In the prior art, gas-phase ion-molecule reaction is mostly carried out in the atmosphere or a high-vacuum environment, active reactant ions are not easy to generate in the atmosphere, the reaction efficiency is low in the high-vacuum environment, both the generation of the reactant ions and the reaction efficiency are difficult to be compatible, and the problems can be solved by constructing low-pressure reaction conditions in the embodiment.
In some embodiments, the voltage difference between the ion transport tube and the ion beam splitter is set to-200V, and the voltage difference between the ion transport tube and the ion beam splitter is not 0 (e.g., may be-200V, -150V, -100V, -50V, -30V, -20V, -10V, -5V, 10V, 20V, 30V, 50V, 100V, 150V, 200V, etc.). The voltage is used for ion fragmentation, in particular, the introduced ions or charged clusters can be accelerated by utilizing the voltage difference and collide and fragment with carrier gas molecules in an ion fragmentation device to generate metal ions; meanwhile, the finally generated metal ions are endowed with certain kinetic energy (the energy can be adjusted so as to regulate and control the reaction process), and the gas-phase ion-molecule reaction can be better induced.
In some embodiments, the carrier is an inert gas. Inert gas does not participate in the reaction.
In some embodiments, the inert gas comprises one of nitrogen and argon.
In some embodiments, the metal compound solution may be an inorganic metal salt solution such as PdCl 2 solution, cuCl solution, auCl 3 solution, agNO 3 solution, etc., and may also be an organic metal compound solution such as Fe (C 5H5)2 solution, (CH 3)2 Hg solution, etc.), but is not limited thereto.
The following is a detailed description of specific examples.
Example 1
The implementation provides a mass spectrometer, as shown in fig. 2, which comprises an ion source 1 (specifically an ESI source), a sealed cavity 2, an ion transmission tube 3, an ion splitting device (composed of ion lenses) 4, a mass analyzer 5 and a detector 6 which are connected in sequence; the sealed cavity 2 is provided with a sample inlet 21 to be tested.
Introducing PdCl 2 solution into an ESI source, introducing nitrogen into a sealed cavity from a sample inlet to be detected, setting the voltage difference between an ion transmission pipe and an ion cracking device to be 50V, setting the air pressure of the ion cracking device to be 30Pa, forming high-strength Pd ions (Pd +), observing a mass spectrogram (shown in figure 4) at the moment, and finding that spectrogram interference can be greatly reduced in a source internal cracking mode to form high-strength Pd +;
then, liquid n-heptane (a non-polar liquid compound difficult to ionize and incapable of being directly analyzed by conventional ESI source mass spectrometry) is placed at an inlet of a sample to be tested, the volatilized gaseous n-heptane and nitrogen enter a sealed ion source cavity, and finally, the adduct ion peak of metal and heptane- [ Pd+C 7H16]+ ] is detected, as shown in FIG. 5.
In summary, the present invention provides a gas-phase ion reaction apparatus, a mass spectrometer, and a method for detecting a nonpolar compound, where the gas-phase ion reaction apparatus is capable of specifically ionizing a nonpolar compound difficult to ionize, and the gas-phase ion reaction apparatus is capable of generating metal ions with strong reactivity through collision and cleavage, and performing gas-phase ion-molecule reaction on the metal ions with strong reactivity and the nonpolar gaseous compound in the ion cleavage apparatus to generate new composite ions, thereby realizing soft ionization of the nonpolar gaseous compound, and the composite ions can be detected later by mass spectrometry.
It is to be understood that the invention is not limited in its application to the examples described above, but is capable of modification and variation in light of the above teachings by those skilled in the art, and that all such modifications and variations are intended to be included within the scope of the appended claims.
Claims (10)
1. The gas-phase ion reaction device is characterized by comprising an ion source, a sealed cavity, an ion transmission pipe and an ion cracking device which are connected in sequence;
And a sample inlet to be tested is arranged on the sealing cavity.
2. The gas phase ion reaction apparatus of claim 1, wherein the ion source is an electrospray ion source, an atmospheric pressure chemical ionization source, a glow discharge source, or a photoionization source.
3. A mass spectrometer comprising the gas phase ion reaction device of any one of claims 1-2, further comprising:
The mass analyzer is connected with the ion cracking device;
And the detector is connected with the mass analyzer.
4. A method for detecting a nonpolar compound using the mass spectrometer of claim 3, said method comprising the steps of:
providing a metal compound solution and a nonpolar compound to be detected, wherein the nonpolar compound to be detected is a nonpolar first gaseous compound;
passing the metal compound solution through an ion source to produce complex ions containing metal elements or cluster ions containing metal elements;
Introducing the complex ions containing metal elements or cluster ions containing metal elements into a sealed cavity, and then introducing the nonpolar first gaseous compound and carrier gas into the sealed cavity from a sample inlet to be tested to form a mixed gas;
Transmitting the mixed gas into an ion cracking device by utilizing an ion transmission pipe, wherein compound ions containing metal elements or cluster ions containing metal elements in the mixed gas collide with carrier gas for cracking to generate metal ions, and the metal ions react with nonpolar first gaseous compounds to obtain compound ions;
and detecting the composite ions by a mass analyzer and a detector, and identifying the nonpolar compound to be detected by the detection result.
5. A method for detecting a nonpolar compound using the mass spectrometer of claim 3, said method comprising the steps of:
Providing a metal compound solution and a nonpolar compound to be detected, wherein the nonpolar compound to be detected is a nonpolar volatile liquid compound, and the nonpolar volatile liquid compound volatilizes to generate a nonpolar second gaseous compound;
passing the metal compound solution through an ion source to produce complex ions containing metal elements or cluster ions containing metal elements;
Introducing the complex ions containing metal elements or cluster ions containing metal elements into a sealed cavity, then placing the nonpolar volatile liquid compound at an inlet of a sample to be tested, and enabling nonpolar second gaseous compound generated by volatilization of the nonpolar volatile liquid compound and a carrier to enter the sealed cavity from the inlet of the sample to be tested to form a mixed gas;
Transmitting the mixed gas into an ion cracking device by utilizing an ion transmission pipe, wherein compound ions containing metal elements or cluster ions containing metal elements in the mixed gas collide with carrier gas for cracking to generate metal ions, and the metal ions react with nonpolar second gaseous compounds to obtain compound ions;
and detecting the composite ions by a mass analyzer and a detector, and identifying the nonpolar compound to be detected by the detection result.
6. The method according to claim 4 or 5, wherein the gas pressure of the ion cracker is set to a range of 10 -1～103 Pa.
7. The method according to claim 4 or 5, wherein a voltage difference between the ion transport tube and the ion splitting device is set to-200V to 200V, and a voltage difference between the ion transport tube and the ion splitting device is not set to 0.
8. The method according to claim 4 or 5, wherein the carrier is an inert gas.
9. The method of claim 8, wherein the inert gas comprises one of nitrogen and argon.
10. The method according to claim 4 or 5, wherein the metal compound solution comprises an inorganic metal salt solution or an organic metal compound solution.
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