CN118078494A - Hydrophobic double-ring target implant for treating corneal edema - Google Patents
Hydrophobic double-ring target implant for treating corneal edema Download PDFInfo
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- CN118078494A CN118078494A CN202410430439.1A CN202410430439A CN118078494A CN 118078494 A CN118078494 A CN 118078494A CN 202410430439 A CN202410430439 A CN 202410430439A CN 118078494 A CN118078494 A CN 118078494A
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- implant
- hydrophobic
- cornea
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- 239000007943 implant Substances 0.000 title claims abstract description 65
- 230000002209 hydrophobic effect Effects 0.000 title claims abstract description 57
- 206010011033 Corneal oedema Diseases 0.000 title claims abstract description 16
- 201000004778 corneal edema Diseases 0.000 title claims abstract description 16
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000001301 oxygen Substances 0.000 claims abstract description 19
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 19
- 210000004087 cornea Anatomy 0.000 abstract description 28
- 230000002093 peripheral effect Effects 0.000 abstract description 13
- 238000000034 method Methods 0.000 abstract description 9
- 210000001519 tissue Anatomy 0.000 abstract description 8
- 238000002513 implantation Methods 0.000 abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 7
- 230000008569 process Effects 0.000 abstract description 6
- 238000005299 abrasion Methods 0.000 abstract description 5
- 230000000903 blocking effect Effects 0.000 abstract description 4
- 230000017074 necrotic cell death Effects 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract description 4
- 210000003560 epithelium corneal Anatomy 0.000 abstract description 3
- 235000015097 nutrients Nutrition 0.000 abstract description 3
- 239000000463 material Substances 0.000 description 7
- 239000010410 layer Substances 0.000 description 6
- 206010030113 Oedema Diseases 0.000 description 4
- 238000001125 extrusion Methods 0.000 description 3
- 206010021143 Hypoxia Diseases 0.000 description 2
- 210000002159 anterior chamber Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000011229 interlayer Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 208000035874 Excoriation Diseases 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- 206010022945 Iris adhesions Diseases 0.000 description 1
- 206010023644 Lacrimation increased Diseases 0.000 description 1
- 206010034960 Photophobia Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 210000003683 corneal stroma Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004317 lacrimation Effects 0.000 description 1
- -1 moisture Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 210000001328 optic nerve Anatomy 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 239000002210 silicon-based material Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000004382 visual function Effects 0.000 description 1
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- Prostheses (AREA)
Abstract
The invention provides a hydrophobic double-ring target implant for treating corneal edema, which relates to the technical field of ophthalmology and comprises a hydrophobic implant, wherein an inner piece is arranged on the hydrophobic implant, an outer piece is arranged outside the inner piece, at least two oxygen permeation holes are formed in the outer piece, the diameter of the inner piece is 5.5-7 mm, and the diameter of the outer piece is 8-9.5 mm. According to the invention, the outer piece is additionally arranged on the periphery of the inner piece, so that the area of the hydrophobic implant is enlarged, the target implant is formed, the inner surface of cornea or the stroma surface between cornea layers is covered as large as possible, the area of water blocking is enlarged, the corneal epithelium bubble in the peripheral area is eliminated, and discomfort such as eye abrasion is avoided. The hydrophobic implant is provided with an oxygen permeation hole for permeation of water and oxygen so as to ensure that nutrient substances enter cornea and avoid anoxic necrosis of cornea tissues, and the edge of the oxygen permeation hole is provided with a round blunt shape so as to ensure the stability of the implantation process of the hydrophobic implant, so that the tearing of the hydrophobic implant in the implantation process can be reduced.
Description
Technical Field
The invention belongs to the technical field of ophthalmology, and particularly relates to a hydrophobic double-ring target implant for treating corneal edema.
Background
The visual function of the eye is mainly dependent on: corneal, lens, vitreous transparency, and retinal, optic nerve function, among other factors, corneal transplantation is a surgical treatment commonly used to repair or replace damaged or disease affected corneal tissue in a patient's eye.
The Chinese patent publication number is: CN219983199U, an interlaminar implantable hydrophobic implant for treating corneal edema, the interlaminar implantable hydrophobic implant for treating corneal edema of the invention and a method of use, the implant may have one or more holes to facilitate substance communication, which would have an important effect on nourishing the cornea but would not result in corneal edema.
The existing corneal implants have the following disadvantages,
1. The diameter of the existing implant is about 6.5mm, the area of the implant is small, the peripheral cornea is in an oedema state, and the discomfort such as red eyes and grinding eyes can be caused by small bubbles under the epithelium of the cornea;
2. If the diameter of the central implant is too large, the nutrition deficiency of cornea tissue is caused, and stroma is dissolved and necrotized. The existing artificial cornea endothelial product design does not solve the clinical problems.
Accordingly, in view of the above, research and improvement on the existing structure and the existing defects are performed to provide a hydrophobic double-ring target implant for treating corneal edema, so as to achieve the purpose of more practical value.
Disclosure of Invention
In order to solve the technical problems, the invention provides a hydrophobic double-ring target implant for treating corneal edema, so as to solve the problems.
The hydrophobic double-ring target implant for treating corneal edema comprises a hydrophobic implant, wherein an inner piece is arranged on the hydrophobic implant, an outer piece is arranged outside the inner piece, and at least two oxygen permeation holes are formed in the outer piece.
Preferably, the diameter of the inner sheet is 5.5mm-7mm.
Preferably, the diameter of the outer sheet is 8mm-9.5mm.
Preferably, the edge of the oxygen permeation hole is in a round shape.
Preferably, the edges of the outer sheet are thinned.
Preferably, the hydrophobic implant may be placed on the intracorneal surface or between the stromal layers of the cornea.
Compared with the prior art, the invention has the following beneficial effects:
According to the invention, the outer piece is additionally arranged on the periphery of the inner piece, so that the area of the hydrophobic implant is enlarged, the target implant is formed, the inner surface of cornea or the stroma surface between cornea layers is covered as large as possible, the area of water blocking is enlarged, the corneal epithelium bubble in the peripheral area is eliminated, and discomfort such as eye abrasion is avoided.
According to the invention, the oxygen permeation holes are formed, so that permeation of water and oxygen is performed, nutrient substances are ensured to enter the cornea, anoxic necrosis of tissues is avoided, the edges of the oxygen permeation holes are rounded, and tearing of the hydrophobic implant in the implantation process can be reduced.
According to the invention, the edge material of the outer sheet is thinner, so that the thin edge can be better matched with the shape and curvature of the cornea, the fitting property and stability of the hydrophobic implant and the cornea are improved, meanwhile, the extrusion of the edge of the outer sheet to the angle of the room can be reduced, and the anterior adhesion of the peripheral iris is prevented.
Drawings
FIG. 1 is a schematic view of the overall structure of a hydrophobic implant according to the present invention.
In the figure, the correspondence between the component names and the drawing numbers is: 1. hydrophobic implant; 2. an outer sheet; 3. an inner sheet; 4. oxygen permeable holes.
Detailed Description
Embodiments of the present invention are described in further detail below with reference to the accompanying drawings and examples. The following examples are illustrative of the invention but are not intended to limit the scope of the invention.
Referring to fig. 1, the present invention provides a hydrophobic double-ring target implant for treating corneal edema, which comprises a hydrophobic implant 1, wherein an inner sheet 3 is arranged on the hydrophobic implant 1, an outer sheet 2 is arranged outside the inner sheet 3, at least two oxygen permeation holes 4 are formed in the outer sheet 2, and oxygen permeation holes 4 are formed, so that water permeation and oxygen permeation are performed, and tissue hypoxia necrosis is avoided;
The diameter of the inner sheet 3 is 5.5mm-7mm, the diameter of the outer sheet 2 is 8mm-9.5mm, the outer sheet 2 is additionally arranged on the periphery of the inner sheet 3, the area of the hydrophobic implant 1 is enlarged, a target implant is formed, the surface of the cornea inner skin or the surface of the cornea interlayer matrix is covered as large as possible, the area of water blocking is increased, the corneal epithelium bubble in the peripheral area is eliminated, and discomfort such as eye abrasion is avoided;
The edge material of the outer sheet 2 is thinner, so that the thin edge can be better matched with the shape and curvature of the cornea, the fitting property and stability of the hydrophobic implant 1 and the cornea are improved, meanwhile, the extrusion of the edge of the outer sheet 2 to the angle of the room can be reduced, and the anterior adhesion of the peripheral iris is prevented; if necessary, the anterior chamber is deepened by combining lens removal to prevent anterior peripheral iris adhesion.
Working principle:
the hydrophobic implant 1 of the present application can be placed between the corneal endocarp surface or the corneal stroma layer, and the different implantation positions thereof adopt different methods, and the corneal endocarp surface implantation process comprises the following steps:
First, implanting a hydrophobic implant 1 into the anterior chamber;
Secondly, pressing the hydrophobic implant 1 to the inner surface of the cornea by using gas;
The process of implantation between cornea layers comprises the following steps:
Firstly, separating a cavity gap in front of a deep matrix or a rear elastic layer by using technologies such as femtosecond laser, freehand dissection, large bubble technology and the like;
Secondly, implanting the hydrophobic implant 1 into the cavity so that the hydrophobic implant serves as a waterproof layer for dehydrating the cornea;
Based on the steps, firstly, the diameter of the inner sheet 3 of the existing implant is about 6.5mm, the area of the inner sheet is smaller, the peripheral cornea is in an edema state, so that discomfort such as redness, eye abrasion, photophobia, lacrimation and the like is caused, the life quality is influenced, the area of the implant is small, the peripheral cornea edema possibly reduces the stability of the implant, the peripheral tissues are expanded by the edema, the gap between the implant and the peripheral tissues is increased, and the displacement, the distortion or the shedding of the implant can be caused, the outer sheet 2 is additionally arranged on the periphery of the inner sheet 3, the area of the hydrophobic implant 1 is enlarged, the target implant is formed, the surface of the inner skin surface or the interlayer stroma of the cornea is covered as large as possible, the area of water blocking is enlarged, the corneal epithelial blisters of the peripheral area are eliminated, the discomfort such as the eye abrasion is avoided, and the oxygen permeable holes 4 are simultaneously formed, the nutrients are guaranteed to enter the cornea, and the oxygen deficiency necrosis is avoided;
In the application, the hydrophobic implant 1 is made of a hydrophobic material, and the hydrophobic material can reduce or prevent the adsorption and permeation of substances such as moisture, body fluid and cells on the surface of the hydrophobic implant 1, so that the side effect of the hydrophobic implant 1 on surrounding tissues is reduced and the functionality of the hydrophobic implant is improved, and the hydrophobic implant 1 can be made of high polymer materials such as polymethyl methacrylate, acrylic acid hydrogel, hydroxyethyl methacrylate, polyvinyl alcohol and the like, and the high polymer materials have low surface energy and high surface tension, so that the hydrophobic implant has hydrophobic performance; the silicon-based material can realize hydrophobic performance through surface nano-structuring, chemical modification and other methods, for example, the material modified by silicon oxide nano-particles has hydrophobic effect, and the material which has hydrophobic effect and is suitable for the hydrophobic implant 1 can be used;
According to the application, the edge material of the outer sheet 2 is thinner, so that the thin edge can be better matched with the shape and curvature of the cornea, the fitting property and stability of the hydrophobic implant 1 and the cornea are improved, meanwhile, the extrusion of the edge of the outer sheet 2 to the angle of the room can be reduced, and the anterior adhesion of the peripheral iris is prevented;
Finally, the distance from any point on the hydrophobic implant 1 to the edge is not more than 3mm, and at least two oxygen permeation holes 4 are formed in the outer sheet 2, the edges of the oxygen permeation holes 4 are round and blunt, and the round and blunt edge of the oxygen permeation holes 4 can reduce tearing of the hydrophobic implant 1 in the implantation process.
The embodiments of the invention have been presented for purposes of illustration and description, and are not intended to be exhaustive or limited to the invention in the form disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, and to enable others of ordinary skill in the art to understand the invention for various embodiments with various modifications as are suited to the particular use contemplated.
Claims (5)
1. A hydrophobic double-loop target implant for treating corneal oedema, comprising a hydrophobic implant (1), characterized in that: the hydrophobic implant (1) is provided with an inner sheet (3), an outer sheet (2) is arranged outside the inner sheet (3), and at least two oxygen permeation holes (4) are formed in the outer sheet (2).
2. A hydrophobic double loop target implant for the treatment of corneal oedema according to claim 1, characterized in that the diameter of the inner sheet (3) is 5.5mm-7mm.
3. A hydrophobic double loop target implant for the treatment of corneal oedema according to claim 2, characterized in that the diameter of the outer sheet (2) is 8mm-9.5mm.
4. A hydrophobic double loop target implant for the treatment of corneal oedema according to claim 1, characterized in that the edge of the oxygen permeable aperture (4) is rounded.
5. A hydrophobic double loop target implant for the treatment of corneal oedema according to claim 3, characterized in that the edges of the outer sheet (2) are arranged to taper.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410430439.1A CN118078494A (en) | 2024-04-11 | 2024-04-11 | Hydrophobic double-ring target implant for treating corneal edema |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410430439.1A CN118078494A (en) | 2024-04-11 | 2024-04-11 | Hydrophobic double-ring target implant for treating corneal edema |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118078494A true CN118078494A (en) | 2024-05-28 |
Family
ID=91149201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410430439.1A Pending CN118078494A (en) | 2024-04-11 | 2024-04-11 | Hydrophobic double-ring target implant for treating corneal edema |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN118078494A (en) |
-
2024
- 2024-04-11 CN CN202410430439.1A patent/CN118078494A/en active Pending
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