CN118064243A - Device for exhausting air at top of vertical tube heat exchanger in reactor by minimally invasive surgery method and application thereof - Google Patents
Device for exhausting air at top of vertical tube heat exchanger in reactor by minimally invasive surgery method and application thereof Download PDFInfo
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- CN118064243A CN118064243A CN202211467718.2A CN202211467718A CN118064243A CN 118064243 A CN118064243 A CN 118064243A CN 202211467718 A CN202211467718 A CN 202211467718A CN 118064243 A CN118064243 A CN 118064243A
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- 238000000034 method Methods 0.000 title claims abstract description 29
- 238000002324 minimally invasive surgery Methods 0.000 title claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 142
- 238000006243 chemical reaction Methods 0.000 claims abstract description 16
- 230000000149 penetrating effect Effects 0.000 claims abstract description 6
- 238000001816 cooling Methods 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 239000002184 metal Substances 0.000 claims description 4
- 239000002131 composite material Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000007789 gas Substances 0.000 description 8
- 238000000855 fermentation Methods 0.000 description 7
- 230000004151 fermentation Effects 0.000 description 7
- 238000007599 discharging Methods 0.000 description 5
- 238000009423 ventilation Methods 0.000 description 5
- 238000005452 bending Methods 0.000 description 4
- 238000010276 construction Methods 0.000 description 4
- 238000006073 displacement reaction Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000003889 chemical engineering Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 229910052755 nonmetal Inorganic materials 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
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Abstract
The application relates to a device for exhausting air at the top of a heat exchanger of a vertical pipe in a reactor by a minimally invasive surgery method and application thereof, and relates to the field of bioengineering. The exhaust device is used in a bioreactor, a plurality of groups of standpipe heat exchangers are arranged in the bioreactor, each group of standpipe heat exchangers comprises a plurality of heat exchange branch pipes, and a liquid inlet main pipe and a liquid outlet main pipe are arranged at the bottom of each standpipe heat exchanger; a through hole is formed in the side surface of one end of the liquid inlet main pipe or the liquid outlet main pipe, which is positioned outside the bioreactor, an eduction pipe is arranged on the through hole, one end of the eduction pipe, which is far away from the through hole, is connected with a gas-liquid discharge pipe, a collecting plate is arranged between the gas-liquid discharge pipe and the eduction pipe, and a gas-liquid discharge valve is arranged at one end of the gas-liquid discharge pipe, which is far away from the eduction pipe; a thin conduit is arranged in the heat exchange branch pipe in a penetrating way, one end of the thin conduit is positioned at the top of the branch pipe, and the other end of the thin conduit is connected to the collecting plate. The application applies the operation principle of surgical minimally invasive surgery to the process of removing the residual gas at the top of the standpipe heat exchanger in the reaction vessel, thereby improving the heat transfer efficiency.
Description
Technical Field
The application relates to the technical field of bioengineering, in particular to a device for exhausting air at the top of a heat exchanger of a vertical tube in a reactor by a minimally invasive surgery method and application thereof.
Background
Heat transfer is a basic operation process in chemical reactions, biological reactions and many fluid engineering, and most of reaction kettles, fermentation tanks, heating tanks and cooling tanks are internally provided with heat exchangers for enhancing heat transfer effect. The heat exchanger of the outer wall of the reaction vessel is mainly an integral jacket, a honeycomb jacket and a semicircle tube jacket; the heat exchanger type inside the reaction vessel mainly comprises a large spiral coil, a spring coil and a vertical tube heat exchanger. The standpipe heat exchanger comprises a shell-and-tube heat exchanger, a double-row tube heat exchanger, a multi-row tube heat exchanger, a U-shaped tube heat exchanger and an inverted U-shaped tube heat exchanger. The structural characteristics and advantages and disadvantages of various heat exchangers inside the reactor are compared with those shown in the following table 1:
table 1 comparison of various heat exchangers in the vessel
In the fields of chemical engineering and biological engineering, equipment with heat exchangers in reaction vessels is very widely used. The standpipe heat exchanger has been used more and more in recent years due to the advantages of baffle function, easy cleaning of the outer wall, small pipe resistance, large installable heat exchange area per unit volume, easy exhaustion of heat transfer medium, etc., and has been widely used in the field of bioengineering in particular.
When the bioreactor is operated in batches, heat exchange medium in the heat exchanger is required to be exhausted before the bioreactor is started, and the standpipe heat exchanger is filled with air, so that pipeline vibration damage and ineffective heat consumption in the high-temperature sterilization process can be avoided. However, in the downcomer just when the heat exchange medium is introduced, the rate of free falling of the heat exchange medium is far greater than the average flow rate, the bottom in the downcomer is filled with liquid, the top is not filled in time, and therefore air is retained at the top of a part of the standpipe and cannot be discharged when the downcomer starts to operate, and the subsequent heat transfer efficiency is affected. In addition, during operation of the reactor, the circulating heat exchange medium contains a small amount of bubbles, which accumulate at the top of the standpipe when the bubble is coalesced to a larger diameter and the buoyancy of the bubble is greater than the drag force during the downward motion. The stagnation of gas at the top of a portion of the standpipe will cause a slowing or even stopping of the flow of heat exchange medium, thereby severely affecting the effective heat exchange area and overall heat transfer efficiency of the heat exchanger. At present, the influence of the gas remained in the pipe on the heat transfer efficiency is not paid attention to enough, and few engineers find the problem and adopt a method of directly taking over the top of the heat exchanger in the reactor and discharging the gas out of the tank, but because of the toxic, harmful and explosive gases in many reaction vessels, the defects of complex construction conditions in the tank, high safety risk, more welding points, high leakage risk of heat exchange medium and the like exist, and further popularization and application of the standpipe heat exchanger in reaction equipment are hindered.
Disclosure of Invention
The application aims to provide a device for removing air at the top of a heat exchanger of a vertical pipe in a reactor by a minimally invasive surgery method and application thereof, so as to solve the problems in the prior art.
In order to achieve the above purpose, the application adopts the following technical scheme:
The device is suitable for a bioreactor, a plurality of groups of standpipe heat exchangers are arranged in the bioreactor, each group of standpipe heat exchangers comprises a plurality of heat exchange branch pipes, a liquid inlet main pipe and a liquid outlet main pipe are arranged at the bottom of each standpipe heat exchanger, one ends of the liquid inlet main pipe and the liquid outlet main pipe are positioned in the bioreactor, and the other ends of the liquid inlet main pipe and the liquid outlet main pipe extend to the outside of the bioreactor in a penetrating way; one end of each heat exchange branch pipe is connected to the liquid inlet main pipe, and the other end is connected to the liquid outlet main pipe;
a through hole is formed in one end of the liquid inlet main pipe or one end of the liquid outlet main pipe, which is positioned outside the bioreactor, an eduction pipe is arranged on the through hole, one end of the eduction pipe, which is far away from the through hole, is connected with a gas-liquid discharge pipe, a collecting plate is arranged between the gas-liquid discharge pipe and the eduction pipe, and a gas-liquid discharge valve is arranged at one end of the gas-liquid discharge pipe, which is far away from the eduction pipe;
A plurality of heat exchange branch pipes are internally provided with thin guide pipes in a penetrating way, one end of each thin guide pipe is positioned at the top of each branch pipe, and the other end of each thin guide pipe is connected to the collecting plate.
In one possible implementation manner, the collecting plate is provided with a plurality of cutting sleeve joints, and the other ends of the plurality of thin guide pipes are respectively connected to the plurality of cutting sleeve joints.
In one possible implementation, the gas-liquid discharge valve is a single valve or a double valve.
In one possible implementation, the end of the thin conduit at the top of the branch pipe is opened in an inclined plane, and the inclination angle is 30-60 degrees.
In one possible implementation, the material of the fine catheter includes at least one of a metal catheter, a plastic catheter, and a composite catheter.
In one possible implementation, the plurality of heat exchange branch pipes are connected to the liquid outlet main pipe after being gathered into a downcomer at the top of each group of the standpipe heat exchangers; one end of the liquid outlet main pipe, which is positioned in the bioreactor, is connected with the descending pipe through an elbow.
In one possible implementation manner, the through hole is formed in one end of the liquid inlet main pipe, which is located outside the bioreactor, and a liquid discharge pipe is further connected to the bottom of one end of the liquid inlet main pipe, which is located outside the bioreactor.
In one possible implementation, the ends of the liquid inlet header pipe and the liquid outlet header pipe located in the bioreactor are welded and sealed by end cover plates; the plurality of groups of standpipe heat exchangers are fixed with the container wall of the bioreactor through fixing brackets; the liquid inlet main pipe and the liquid outlet main pipe are fixedly connected through a connecting plate, and the bottom of the connecting plate is welded and fixed with the container wall of the bioreactor through a bottom supporting rod.
In one possible implementation, the standpipe heat exchanger at least comprises one or two of a shell-and-tube heat exchanger, a double-row tube heat exchanger, a multi-row tube heat exchanger, a U-tube heat exchanger and an inverted U-tube heat exchanger which are vertically or obliquely installed.
In one possible implementation, the bioreactor includes at least one of a reaction kettle, a fermentation tank, a cooling tank, and a heating tank with a heat transfer function.
The technical scheme provided by the application has the beneficial effects that at least:
(1) The application applies the operation principle of surgical minimally invasive surgery to the discharge process of the top retention gas in the standpipe heat exchanger in the bioreactor, thereby obviously improving the heat transfer efficiency;
(2) All construction operations are performed outside the reactor, and only one through hole is formed at the position of the heat transfer medium liquid inlet main pipe or the heat transfer medium liquid outlet main pipe, so that the method has the advantages of good safety and high process reliability aiming at the transformation and the structural influence of the heat exchanger and the reaction vessel;
(3) The application gathers the thin conduit to the gathering plate and leads out to the gas-liquid discharge pipe for centralized discharge, and has the characteristics of simple construction, rapidness and convenience.
Drawings
The accompanying drawings are included to provide a further understanding of the application and are incorporated in and constitute a part of this specification, illustrate the application and together with the embodiments of the application, serve to explain the application. In the drawings:
FIG. 1 is a schematic diagram showing the front view of a device for exhausting the top air of a heat exchanger of a standpipe in a reactor by a minimally invasive surgery method and the application of the device according to an exemplary embodiment of the present application;
FIG. 2 is a schematic side view of a device for removing top air from a heat exchanger of a standpipe in a reactor by minimally invasive surgery and a side view of the device for removing top air from a heat exchanger of a standpipe in a reactor according to an illustrative embodiment of the present application;
FIG. 3 shows a schematic view of a partial enlarged structure at C of FIG. 1;
FIG. 4 shows a cross-sectional view at A-A of FIG. 1;
FIG. 5 shows a cross-sectional view at B-B of FIG. 1;
FIG. 6 is a schematic view showing a part of the structure of a device for exhausting the top air of a heat exchanger of a standpipe in a reactor by a minimally invasive surgery method and a pipe bending guiding tool applied by the device according to an exemplary embodiment of the present application;
FIG. 7 is a schematic view of a portion of a device for exhausting top air from a heat exchanger of a standpipe in a reactor and a bend guiding tool for use with the device in accordance with an illustrative embodiment of the present application;
FIG. 8 is a schematic view of a device for exhausting air from the top of a heat exchanger of a standpipe in a reactor and a supporting tube used in the device for exhausting air by a minimally invasive surgery method according to an exemplary embodiment of the present application;
In the figure: 1. a container wall; 2. a liquid discharge pipe; 3. a liquid inlet main pipe; 4. a collection plate; 5. a liquid outlet main pipe; 6. a heat exchange branch pipe; 7. a thin catheter; 8. a fixed bracket; 9. the top of the branch pipe; 10. an end cover plate; 11. a bottom support bar; 12. a connecting plate; 13. a down pipe; 14. an eduction tube; 15. a gas-liquid discharge pipe; 16. a ferrule joint; 17. a support tube; 1701. bending the sleeve; 1702. a support sheet; 20. A bend guiding tool; 21. a guide sleeve; 22. activating elbow; 23. a positioning groove; 24. a fixed rod; 25. and (5) shifting the locking bolt.
Detailed Description
The following description of the embodiments of the present application will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Wherein like parts are designated by like reference numerals. It should be noted that the words "front", "rear", "left", "right", "upper" and "lower" used in the following description refer to directions in the drawings of the present application, and the words "bottom" and "top", "inner" and "outer" refer to directions toward or away from, respectively, a specific component. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present specification, the meaning of "plurality" is two or more.
The application will be further described with reference to the drawings and examples.
Example 1
FIG. 1 is a schematic diagram showing a front view of an apparatus for exhausting air from the top of a heat exchanger of a standpipe in a reactor and an application thereof according to a minimally invasive surgery method, wherein the apparatus is applicable to a bioreactor, the bioreactor is internally provided with a plurality of groups of heat exchangers of standpipe, each group of heat exchangers of standpipe comprises a plurality of heat exchange branch pipes 6, a liquid inlet manifold 3 and a liquid outlet manifold 5 are arranged at the bottom of each group of heat exchangers of standpipe, a first end of the liquid inlet manifold 3 and a first end of the liquid outlet manifold 5 are positioned in the bioreactor, and a second end of the liquid inlet manifold 3 and a second end of the liquid outlet manifold 5 extend through to the outside of the bioreactor; the first ends of the heat exchange branch pipes 6 are connected to the liquid inlet main pipe 3, and the second ends of the heat exchange branch pipes 6 are connected to the liquid outlet main pipe 5.
Referring to fig. 1, 2, 3, 4 and 5, a through hole is formed in a side surface of one end of the liquid inlet manifold 3 or the liquid outlet manifold 5, which is located outside the bioreactor. The through hole may be formed in the liquid inlet manifold 3 or the liquid outlet manifold 5, and in this example, the through hole is formed in the liquid inlet manifold 3. Referring to fig. 4, an outlet pipe 14 is installed on the through hole, one end of the outlet pipe 14 away from the through hole is connected with a gas-liquid discharge pipe 15, a collecting plate 4 is installed between the gas-liquid discharge pipe 15 and the outlet pipe 14, and a gas-liquid discharge valve (not shown) is installed at one end of the gas-liquid discharge pipe 15 away from the outlet pipe 14. Optionally, the gas-liquid discharge valve is a single valve or a double valve, the single valve is used for gas-liquid mixing discharge, and the double valve is used for gas-liquid separation and then discharge respectively. Preferably, the gas-liquid discharge valve is a single valve gas-liquid mixed discharge.
Referring to fig. 1, 2, 3,4 and 5, the plurality of heat exchange branch pipes 6 are each provided with a thin conduit 7, the top parts of the plurality of heat exchange branch pipes 6 are each provided with a branch pipe top 9, the first ends of the thin conduits 7 are located at the positions of the branch pipe tops 9, and the second ends of the thin conduits 7 are connected to the collecting plate 4. In this example, the collecting plate 4 has a plurality of ferrule junctions 16 thereon, and the second ends of the plurality of thin conduits 7 are respectively connected to the plurality of ferrule junctions 16. Optionally, the connection means of the thin conduit 7 to the collection plate 4 includes, but is not limited to, one of welding, fusion, and a ferrule-type connector connection.
In the embodiment of the present application, referring to fig. 6 and 7, the thin conduit 7 may be inserted into the plurality of heat exchange branch pipes 6 through the pipe bending guiding tool 20, wherein the pipe bending guiding tool 20 includes a guiding sleeve 21, a movable elbow 22, a positioning slot 23, a fixing rod 24 and a displacement locking bolt 25, an inclined surface angle of the connection between the inclined end surface of the guiding sleeve 21 and the movable elbow 22 is 45 °, the movable elbow 22 is 45 ° elbow, and the inclined end surfaces of the movable elbow 22 and the guiding sleeve 21 are connected by a hinge. The bottom of one end of the guide sleeve 21 far away from the movable elbow 22 is provided with a positioning groove 23, a fixing rod 24 is arranged in the positioning groove 23 in a penetrating way, detachable connection is realized through a displacement locking bolt 25, the fixing rod 24 is used for fixing the movable elbow 22, the positioning groove 23 and the displacement locking bolt 25 are used for opening or locking the fixing rod 24, and the movable elbow 22 is ensured to guide the thin guide pipe 7 and the guide tool 20 for discharging the elbow.
It should be noted that, the bend guiding tool 20 is disposed at the turning position where the liquid inlet manifold 3 is communicated with each heat exchange branch pipe 6, and the length of the guiding sleeve 21 is matched with the length of the liquid inlet manifold 3 of the standpipe heat exchanger, so that the thin conduit 7 can be bent and turned after extending into the liquid inlet manifold 3 and enter each heat exchange branch pipe 6. Wherein the inner diameter of the guide sleeve 21 and the movable elbow 22 is larger than the outer diameter of the thin conduit 7. Preferably, the difference between the inner diameter of the guide sleeve 21 and the activating bend 22 and the outer diameter of the thin catheter 7 is between 1 and 10 mm.
In the embodiment of the present application, referring to fig. 8, on the other hand, the fine conduit 7 may be inserted into the plurality of heat exchange branch pipes 6 through the supporting pipe 17, where the supporting pipe 17 is also disposed at the turning position where the liquid inlet manifold 3 is communicated with each heat exchange branch pipe 6, and whether the fine conduit 7 is installed is determined according to different working conditions, when the flow rate of the heat exchange medium is fast or the fine conduit is made of a non-metal material, the fine conduit 7 is preferentially installed, mainly preventing vibration friction damage of the fine conduit 7 at the turning position under the working conditions, and preventing displacement caused by dead weight, so that the positioning of the tail end of the fine conduit 7 at the top of the branch pipe is deviated. The support tube 17 is composed of a curved sleeve 1701 made of metal and a support sheet 1702, the inside diameter of the curved sleeve 1701 being larger than the outside diameter of the fine catheter 7, preferably by a difference of between 1 and 10 mm. After the bent portion of the curved sleeve 1701 is positioned to the heat exchange manifold 6, the support sheet 1702 is made perpendicular to the intake manifold 3 by the push rod. Optionally, after the thin catheter 7 is worn, the support tube 17 can be taken out, and can also be left in the liquid inlet main pipe 3 to further play a role in protection.
Example two
In an alternative embodiment, referring to fig. 1,2, 3, 4 and 5, the end of the thin conduit 7 at the top 9 of the branch pipe is open at an inclined plane, with an inclination of 30-60 °. The material of the fine conduit 7 at least comprises one of a metal conduit, a plastic conduit and a composite conduit. Wherein, a plurality of heat exchange branch pipes 6 can be assembled into a descending pipe 13 at the top of each group of standpipe heat exchangers and then connected to the liquid outlet main pipe 5.
Wherein, the liquid inlet main pipe 3 is positioned at the bottom of one end outside the bioreactor and is also connected with a liquid discharge pipe 2 for discharging the liquid in the heat exchange pipe.
When the plurality of heat exchange branch pipes 6 are individually connected to the liquid outlet main pipe 5, the ends of the liquid inlet main pipe 3 and the liquid outlet main pipe 5 which are positioned in the bioreactor are welded and sealed by the end cover plate 10.
When the plurality of heat exchange branch pipes 6 are assembled into a descending pipe 13 at the top of each group of standpipe heat exchangers and then connected to the liquid outlet main pipe 5, one end of the liquid inlet main pipe 3 positioned in the bioreactor is welded and sealed by the end cover plate 10, and one end of the liquid outlet main pipe 5 positioned in the bioreactor is connected with the descending pipe 13 by an elbow (not shown in the figure).
It should be noted that the solution in which the plurality of heat exchange branches 6 are joined to the outlet header 5 after being joined to one downcomer 13 at the top of each stack of riser heat exchangers does not occur in the inverted U-tube heat exchanger solution, but does occur in the solution without shell-and-tube heat exchangers, double-row tube heat exchangers or multiple-row tube heat exchangers.
The plurality of groups of standpipe heat exchangers are welded and fixed with the container wall 1 of the bioreactor through a fixed bracket 8. The liquid inlet main pipe 3 and the liquid outlet main pipe 5 are fixedly connected through a connecting plate 12, the bottom of the connecting plate 12 is welded and fixed with the container wall 1 of the bioreactor through a bottom supporting rod 11, and the stability of the whole structure is improved.
Optionally, the standpipe heat exchanger at least comprises one or two of a shell-and-tube heat exchanger, a double-row tube heat exchanger, a multi-row tube heat exchanger, a U-shaped tube heat exchanger and an inverted U-shaped tube heat exchanger which are vertically or obliquely installed. The bioreactor at least comprises one of a reaction kettle, a fermentation tank, a cooling tank and a heating tank with a heat transfer function, and the embodiment is not limited to this.
For a better understanding of the present application, reference is made to the following description of two embodiments, taken in conjunction with the accompanying drawings. It should be noted that the embodiments described in this specific embodiment are only some embodiments of the present application, and do not limit the scope of protection of the present application.
Example III
In a specific embodiment, the total volume of a ventilation fermenter is 150m 3, please refer to fig. 1, 2 and 3, nine groups of inverted U-shaped tube heat exchangers are arranged in the container, a single group of heat exchangers consists of seven inverted U-shaped stainless steel heat exchange branch pipes 6 with phi 57 multiplied by 3.5, and every three groups of adjacent inverted U-shaped heat exchangers are connected in series with the liquid inlet header pipes 3 of the next group outside the container through the liquid outlet header pipes 5 of the previous group. One end of seven heat exchange branch pipes 6 of the single-group heat exchanger is connected with the liquid inlet main pipe 3, and the other end is connected with the liquid outlet main pipe 5. The two sides of the single-group heat exchanger are welded and fixed with the container wall 1 through the fixing bracket 8. The ends of the liquid inlet main pipe 3 and the liquid outlet main pipe 5 in the container are welded and sealed by end cover plates 10, the ends are reinforced and fixed by connecting plates 12, and the bottoms of the liquid inlet main pipe 3 and the liquid outlet main pipe 5 are welded and fixed with the container wall 1 by bottom supporting rods 11. The liquid inlet main pipe 3 is provided with a liquid discharge pipe 2 at the bottom of one side outside the container and is used for discharging liquid in the heat exchange pipe.
Referring to fig. 1,2, 3, 4 and 5, a through hole is formed on the side of the inlet manifold 3 outside the container wall 1, and an outlet pipe 14 of Φ89×3.5 is connected. Seven fine guide pipes 7 are led into the liquid inlet main pipe 3 by adopting a bent pipe guiding tool 20 to the top 9 of each heat exchange branch pipe 6 of the heat exchanger, the fine guide pipes 7 extend downwards to an eduction pipe 14 and are connected to the collecting plate 4, and the lengths of the fine guide pipes 7 are different.
In this example, the fine catheter 7 is made of 316L stainless steel, and has a specification of Φ4X0.5. One end of the thin conduit is positioned at the top 9 of the branch pipe and is provided with an opening with an inclined plane, the inclined angle is 45 degrees, and the other end of the thin conduit is connected with a clamping sleeve joint 16 on the collecting plate 4.
The collecting plate 4 is positioned between the eduction tube 14 and the gas-liquid discharge tube 15, is a part for intensively connecting the thin guide tube 7 and educing the gas out of the inverted U-shaped tube heat exchanger, and the rear end of the gas-liquid discharge tube 15 is provided with a gas-liquid discharge valve, which can be used for gas-liquid mixed discharge (single valve) or gas-liquid separation and then separate discharge (double valve) in the operation process.
In the embodiment of the application, the application is modified aiming at the standpipe heat exchanger in the 150m 3 ventilation fermentation tank, and the retention gas in the standpipe heat exchanger can be effectively removed in the running operation process. At the same circulating water flow (250 m 3/h), the heat transfer coefficient is improved from the original 2100 kJ/(m 2.h.DEG C) to 2800 kJ/(m 2.h.DEG C), which shows that the heat transfer efficiency of the ventilation fermentation tank can be effectively improved by adopting the exhaust device. After minimally invasive surgery is performed on the standpipe heat exchanger of the reaction vessel, the method can be applied to various attached standpipe heat exchangers in the reactor, including but not limited to a reaction kettle, a fermentation tank, a cooling tank and a heating tank with heat transfer function. The heat transfer medium may be water, heat transfer oil, and other liquid media for heat transfer.
Example IV
In a specific embodiment, referring to fig. 3, 4 and 5, a total volume of the ventilation fermenter is 60m 3, six groups of double row standpipe heat exchangers (not shown) are arranged in the container, a single group of heat exchangers consists of ten (two rows of) vertical phi 57 x 3.5 stainless steel heat exchange branch pipes 6, heat exchange medium enters from a liquid inlet manifold 3 at the bottom, flows upwards through the ten heat exchange branch pipes 6, is converged to a descending pipe 13 of phi 108 x 4 at the top of the heat exchanger, and then flows out from the bottom of the heat exchanger through a liquid outlet manifold 5.
Wherein every three groups of adjacent double-row vertical heat exchangers are connected in series with the liquid inlet main pipe 3 of the next group outside the container through the liquid outlet main pipe 5 of the upper group. The two sides of the single-group heat exchanger are welded and fixed with the container wall 1 through the fixing bracket 8. One end of the liquid inlet main pipe 3 positioned in the bioreactor is welded and sealed by an end cover plate 10, one end of the liquid outlet main pipe 5 positioned in the bioreactor is connected with a descending pipe 13 by an elbow, the two are reinforced and fixed by a connecting plate 12, and the bottom of the liquid inlet main pipe is welded and fixed with the container wall 1 by a bottom supporting rod 11. The liquid inlet main pipe 3 is provided with a liquid discharge pipe 2 at the bottom of one side outside the container and is used for discharging liquid in the heat exchange pipe.
Referring to fig. 3, 4 and 5, a through hole is formed on the side surface of the inlet manifold 3 outside the container wall 1, and an outlet pipe 14 with a diameter of 89×3.5 is connected. A support pipe 17 is adopted in the liquid inlet main pipe 3 to guide a thin guide pipe 7 to the branch pipe top 9 of each heat exchange branch pipe 6 of the heat exchanger, and the thin guide pipe 7 extends downwards to an eduction pipe 14 and is connected to the collecting plate 4. The fine catheter 7 is made of 316L stainless steel and has a specification of phi 4 multiplied by 0.5. One end of the thin conduit is positioned at the top 9 of the branch pipe and is provided with an opening with an inclined plane, the inclined angle is 45 degrees, and the other end of the thin conduit is connected with a clamping sleeve joint 16 on the collecting plate 4.
The collecting plate 4 is located between the eduction tube 14 and the gas-liquid discharge tube 15, and the rear end of the gas-liquid discharge tube 15 is provided with a gas-liquid discharge valve, which can be used for gas-liquid mixed discharge (single valve) or separate discharge (double valve) after gas-liquid separation during operation.
In the embodiment of the application, the modification of the application is carried out on the standpipe heat exchanger in the 60m 3 ventilation fermentation tank, and the retention gas in the standpipe heat exchanger can be effectively removed in the running operation process. At the same circulating water flow rate (100 m 3/h), the heat transfer coefficient is improved by 30% compared with that before modification.
In summary, the application is based on the working principle of surgical minimally invasive surgery, creatively opens a through hole at the heat transfer medium liquid inlet main pipe or the liquid outlet main pipe at the outer side of the reaction vessel, introduces one or more thin pipes to the top of each branch pipe of the standpipe heat exchanger, and the thin pipes are downwards converged to the gas-liquid discharge port positioned at the liquid inlet main pipe or the liquid outlet main pipe, so that the top air in the standpipe heat exchanger is discharged by utilizing the pressure difference between the inside of the heat transfer branch pipe and the gas-liquid discharge port in the working process of the heat transfer medium, and the application has the characteristics of simple construction, good safety and high process reliability.
In the embodiments disclosed herein, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and for example, "connected" may be a fixed connection, a removable connection, or an integral connection; "coupled" may be directly coupled or indirectly coupled through intermediaries. The specific meaning of the above terms in the embodiments of the present disclosure will be understood by those of ordinary skill in the art according to the specific circumstances.
The foregoing is only a preferred embodiment of the application, it being noted that: it will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the principles of the present application, and such modifications and adaptations are intended to be comprehended within the scope of the application.
Claims (10)
1. The device is suitable for a bioreactor, a plurality of groups of standpipe heat exchangers are arranged in the bioreactor, each group of standpipe heat exchangers comprises a plurality of heat exchange branch pipes (6), a liquid inlet main pipe (3) and a liquid outlet main pipe (5) are arranged at the bottom of each standpipe heat exchanger, one end of each liquid inlet main pipe (3) and one end of each liquid outlet main pipe (5) are positioned in the bioreactor, and the other end of each liquid inlet main pipe extends to the outside of the bioreactor in a penetrating way; one end of each heat exchange branch pipe (6) is connected to the liquid inlet main pipe (3), and the other end is connected to the liquid outlet main pipe (5);
The device is characterized in that a through hole is formed in one end of the liquid inlet main pipe (3) or the liquid outlet main pipe (5) positioned outside the bioreactor, an eduction pipe (14) is arranged on the through hole, one end of the eduction pipe (14) away from the through hole is connected with a gas-liquid discharge pipe (15), a collecting plate (4) is arranged between the gas-liquid discharge pipe (15) and the eduction pipe (14), and a gas-liquid discharge valve is arranged at one end of the gas-liquid discharge pipe (15) away from the eduction pipe (14);
a plurality of heat exchange branch pipes (6) are internally provided with thin guide pipes (7) in a penetrating way, one ends of the thin guide pipes (7) are positioned at the positions of the top parts (9) of the branch pipes, and the other ends of the thin guide pipes are connected to the collecting plate (4).
2. The device for exhausting the air at the top of the vertical tube heat exchanger in the reactor by the minimally invasive surgery method according to claim 1 and the application thereof, wherein the collecting plate (4) is provided with a plurality of cutting sleeve joints (16), and the other ends of the plurality of thin guide tubes (7) are respectively connected to the cutting sleeve joints (16).
3. The device for removing air from the top of a heat exchanger of a standpipe in a reactor by minimally invasive surgery and the application thereof according to claim 1, wherein the gas-liquid discharge valve is a single valve or a double valve.
4. The device for exhausting the air at the top of the heat exchanger of the vertical tube in the reactor by the minimally invasive surgery method according to claim 1 and the application thereof, wherein one end of the thin conduit (7) positioned at the top (9) of the branch tube is provided with an inclined opening, and the inclination angle is 30-60 degrees.
5. The device for removing the air at the top of the heat exchanger of the vertical tube in the reactor by the minimally invasive surgery method according to claim 1 and the application thereof, wherein the material of the thin conduit (7) at least comprises one of a metal conduit, a plastic conduit and a composite conduit.
6. The device for removing the air at the top of a standpipe heat exchanger in a reactor and the application thereof according to the minimally invasive surgery method of claim 1, wherein a plurality of heat exchanging branch pipes (6) are connected to the liquid outlet main pipe (5) after being converged into a descending pipe (13) at the top of each group of standpipe heat exchangers;
one end of the liquid outlet main pipe (5) positioned in the bioreactor is connected with the down pipe (13) through an elbow.
7. The device for exhausting the air at the top of the heat exchanger of the vertical tube in the reactor by the minimally invasive surgery method according to claim 1 and the application thereof, wherein the through hole is formed in one end of the liquid inlet main pipe (3) positioned outside the bioreactor, and a liquid discharge pipe (2) is further connected to the bottom of one end of the liquid inlet main pipe (3) positioned outside the bioreactor.
8. The device for removing air at the top of a standpipe heat exchanger in a reactor by a minimally invasive surgery method and the application thereof according to claim 1, wherein one end of the liquid inlet main pipe (3) and one end of the liquid outlet main pipe (5) which are positioned in the bioreactor are welded and sealed by an end cover plate (10);
a plurality of groups of standpipe heat exchangers are fixed with the container wall (1) of the bioreactor through a fixing bracket (8);
The liquid inlet main pipe (3) and the liquid outlet main pipe (5) are fixedly connected through a connecting plate (12), and the bottom of the connecting plate (12) is welded and fixed with the container wall (1) of the bioreactor through a bottom supporting rod (11).
9. The device for removing air from the top of a standpipe heat exchanger in a reactor by a minimally invasive surgery method and the application thereof according to claim 1, wherein the standpipe heat exchanger at least comprises one or two combinations of a shell-and-tube heat exchanger, a double-row tube heat exchanger, a multi-row tube heat exchanger, a U-shaped tube heat exchanger and an inverted U-shaped tube heat exchanger which are vertically or obliquely installed.
10. The apparatus for removing air from the top of a standpipe heat exchanger in a reactor and the use thereof according to claim 1, wherein the bioreactor comprises at least one of a reaction kettle, a fermenter, a cooling tank and a heating tank with heat transfer function.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211467718.2A CN118064243A (en) | 2022-11-22 | 2022-11-22 | Device for exhausting air at top of vertical tube heat exchanger in reactor by minimally invasive surgery method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211467718.2A CN118064243A (en) | 2022-11-22 | 2022-11-22 | Device for exhausting air at top of vertical tube heat exchanger in reactor by minimally invasive surgery method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118064243A true CN118064243A (en) | 2024-05-24 |
Family
ID=91102748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211467718.2A Pending CN118064243A (en) | 2022-11-22 | 2022-11-22 | Device for exhausting air at top of vertical tube heat exchanger in reactor by minimally invasive surgery method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN118064243A (en) |
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2022
- 2022-11-22 CN CN202211467718.2A patent/CN118064243A/en active Pending
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