CN118059164A - Traditional Chinese medicine composition and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition and preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition, a preparation method and application thereof, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-20 parts of cassia twig, 20-30 parts of fennel, 15-30 parts of radix bupleuri, 8-15 parts of angelica, 2-5 parts of evodia rutaecarpa, 4-10 parts of white peony root, 5-10 parts of liquorice, 16-26 parts of cinnamon and 9-17 parts of poria cocos. The preparation method comprises the following steps: preparing fennel extract, poria cocos extract, cassia twig extract, radix bupleuri extract, angelica extract, white peony root extract, licorice extract and cinnamon extract, mixing to obtain mixed extract, soaking fructus evodiae in the mixed extract, and carrying out reflux extraction to obtain the traditional Chinese medicine composition. The monarch drug in the invention warms channels, dissipates cold, the ministerial drug activates blood, warms and removes obstruction, and has the effects of liver softening, yin nourishing, and the adjuvant and guide drug assists the monarch drug to further achieve better effects; monarch, minister, assistant and guide, synergistic effect and inedible.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition, and a preparation method and application thereof.
Background
Seminal vein varicose veins are usually asymptomatic, and are often found in routine physical examination, or in self-examination, as painless earthworm-like masses of the scrotum, or in medical care due to infertility. Some patients may have symptoms such as distention feeling, dull pain, discomfort, etc., and symptoms are aggravated after standing and walking, and symptoms can be relieved or disappeared after lying on the back. Can be combined with varicose vein of lower limb, hemorrhoid, etc. For varicoceles, western medicine has no obvious targeted medicine at present, and is mostly treated by simple surgery, but the surgery has larger damage to the body of a patient and limited curative effect. When the traditional Chinese medicine is used for treating varicocele, the traditional Chinese medicine is started from a pathogenesis, can achieve better curative effect, and has no harm to the body.
The prior art discloses a traditional Chinese medicine composition for treating varicocele and oviduct obstruction, a preparation and application thereof, and the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight with reference to Chinese patent CN 105434515B: 200-400 parts of herba patriniae, 30-80 parts of medulla Tetrapanacis, 200-400 parts of semen vaccariae, 100-200 parts of fructus liquidambaris, 200-400 parts of caulis spatholobi, 150-250 parts of luffa and 50-150 parts of pangolin scales. The patent mainly has the effects of clearing heat and detoxicating, promoting blood circulation and removing blood stasis, but the pathogenesis of varicocele is also possibly liver cold, and if the patent mainly has the effects of clearing heat and detoxicating, promoting blood circulation and removing blood stasis, the varicocele caused by the liver cold is ineffective, and even the illness state is aggravated. Therefore, development of a traditional Chinese medicine composition for preparing a medicine for treating varicocele caused by liver cold is urgently needed.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition, a preparation method and application thereof, and solves the problem that no medicine for treating varicocele caused by liver cold exists in the preparation of the traditional Chinese medicine composition for treating varicocele in the prior art.
The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-20 parts of cassia twig, 20-30 parts of fennel, 15-30 parts of radix bupleuri, 8-15 parts of angelica, 2-5 parts of evodia rutaecarpa, 4-10 parts of white peony root, 5-10 parts of liquorice, 16-26 parts of cinnamon and 9-17 parts of poria cocos.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 14-16 parts of cassia twig, 23-27 parts of fennel, 20-25 parts of radix bupleuri, 10-13 parts of angelica, 3-4 parts of evodia rutaecarpa, 6-8 parts of white peony root, 6-8 parts of liquorice, 20-22 parts of cinnamon and 12-14 parts of poria cocos.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15 parts of cassia twig, 25 parts of common fennel, 23 parts of radix bupleuri, 12 parts of Chinese angelica, 3 parts of evodia rutaecarpa, 7 parts of white peony root, 7 parts of liquorice, 21 parts of cinnamon and 13 parts of poria cocos.
The second purpose of the invention is to protect the preparation method of the traditional Chinese medicine composition, which specifically comprises the following steps:
preparing a fennel extract: pulverizing fructus Foeniculi, bagging, decocting in water for 30-45 min, and filtering to obtain fructus Foeniculi extractive solution;
preparing a poria cocos extracting solution: slicing poria cocos, refluxing ethanol for 1-2 h, and filtering to obtain poria cocos extract;
the method for preparing the cassia twig extract, the bupleurum extract, the angelica extract, the white peony root extract, the liquorice extract and the cinnamon extract is the same as the method for preparing the poria extract;
mixing the obtained fructus Foeniculi extract, poria extract, ramulus Cinnamomi extract, bupleuri radix extract, radix Angelicae sinensis extract, radix Paeoniae alba extract, glycyrrhrizae radix extract, and cortex Cinnamomi extract to obtain mixed extract;
preparing a traditional Chinese medicine composition: soaking evodia rutaecarpa in the mixed extracting solution for 1-1.5 h, refluxing for 45-60 min, filtering and removing the solvent to obtain the traditional Chinese medicine composition.
Preferably, when preparing the fennel extract, fennel is crushed to 100-200 meshes.
Preferably, when the fennel extract is prepared, the mass ratio of fennel to water is 1:6-8.
Preferably, when the poria cocos extract is prepared, the poria cocos is sliced to 1-2 mm.
Preferably, when the poria cocos extract is prepared, the mass ratio of the poria cocos to the ethanol is 1:10-12.
The third purpose of the invention is to protect the application of the traditional Chinese medicine composition in preparing medicines for treating varicocele.
Preferably, the varicocele is varicocele caused by liver cold.
Pharmacological effects of the raw materials in the traditional Chinese medicine composition:
Ramulus Cinnamomi: pungent and sweet in flavor and warm in nature. It enters heart, lung and bladder meridians. Ramulus Cinnamomi is pungent and dispersed and is warm and unblocked, and sweet and warm and can promote yang. Warm, smooth, damp helps yang qi of the body and smooth blood vessels of the body. Enters lung and bladder meridians, and is good at dispersing wind-cold and relieving exterior wind-cold or pathogenic wind. It enters heart meridian and blood system, and is good at warming and activating yang, dispelling cold evil, activating blood vessels, smoothening chest yang, warming and resolving water dampness and relieving pain. Less sweating than Ma Huang, it is good at supporting yang and smoothing blood vessels. It is indicated for exterior syndrome due to wind-cold, exterior syndrome due to deficiency and excess, and cold syndrome due to deficiency, excess or exterior-cold with direct middle energizer or yang deficiency with endogenous sensation. It is indicated for both qi and blood failing to treat blood stasis with cold and yang deficiency with water retention.
Fennel: has effects of invigorating stomach, regulating qi-flowing, sterilizing, preventing infection, dispelling cold, and relieving pain. Stomach invigorating and qi regulating: the fennel oil contained in the fennel can stimulate the nerve vessels of intestines and stomach, discharge gas accumulated in intestines and stomach, and play a role in invigorating stomach and promoting qi. In addition, the fennel contains anethole component, which can effectively reduce the angina caused by inflammation, irritation and regurgitation. Dispelling cold and relieving pain: fennel has the effects of dispelling cold and relieving pain, and can be used for treating cold hernia abdominal pain, lower abdomen crymodynia, and joint muscle pain, numbness and difficulty in flexion and extension caused by wind cold.
Bupleurum root: pungent, bitter and slightly cold in property. It enters liver, gallbladder and lung meridians. Radix bupleuri, bitter in flavor, has the effect of releasing and dispersing, is aromatic and has the effect of ascending, and is clear of the slightly cold energy, entering liver and gall bladder meridians. Not only disperse the pathogenic qi of the gallbladder to dispel the heat, but also disperse the qi of the liver and gallbladder to sooth the liver and relieve the stagnation, and lift the qi of the liver and gallbladder to clear yang to lift the liver and gallbladder to collapse, which is the principal drug of liver and gallbladder meridians. Raw materials are used for ascending and clearing, vinegar is used for ascending and clearing, and the force of clearing and relieving is reduced, and the force of soothing liver is increased.
Chinese angelica root: sweet and pungent in flavor, warm in nature, and enters liver, heart and spleen meridians. Dang Gui can tonify and moisten, pungent and warm in nature, and dispel the flow of qi, enter liver and heart meridians and spleen meridians. It is good at replenishing blood and activating blood, regulating menstruation and relieving pain, relaxing bowel and expelling cold, and is suitable for treating constipation due to blood deficiency and blood stasis, especially constipation due to dryness of the intestines, and is not only a key herb for regulating menstruation in gynecology but also a good blood-replenishing product in internal medicine and is commonly used for detumescence and wound therapy in surgery.
Hao Zhu Yu: pungent, bitter and hot. It enters liver, spleen, stomach and meridians. Evodia rutaecarpa is pungent and hot and fragrant, bitter and dry, and has stronger effect. It enters liver meridian and spleen, stomach and meridian. It is good at soothing liver, lowering the adverse rise of qi of the liver and blood, warming the liver, dispelling cold, wen Yangsao wet, regulating the liver and stomach, relieving pain, stopping hiccup, and killing parasites. It is used externally to eliminate dampness, kill snail, relieve itching, and lower blood pressure. It is indicated for all syndromes of liver cold and qi adverse (stagnation) with damp-retention and yang deficiency. Has strong efficacy and is suitable for oral administration and external use.
White peony root: slightly cold in nature, bitter in taste, sour in flavor, enter liver meridian and spleen meridian. Has effects of removing blood stasis, dredging collaterals, softening liver, relieving pain, and caring skin. The white peony root enters liver and spleen meridians, has the effects of harmonizing liver and spleen, and softening liver to stop pain, is suitable for treating pains in hypochondrium caused by liver depression and blood deficiency, epigastric and abdominal spasm pain, pains in liver and blood deficiency, pains in limb spasm caused by malnutrition of tendons and vessels, and the like, and can play the roles of softening liver to stop pain.
Licorice root: sweet and flat property, it enters heart, lung, spleen and stomach meridians. Licorice root, radix Glycyrrhizae Praeparata, sweet in taste, nourishes and moistens slowly, produces a flat and cool sensation, and a flat and warm sensation, and it enters the spleen and lung meridians and stomach and heart meridians. Not only tonify qi and strengthen middle energizer, but also relieve spasm and pain, alleviate drug properties, and also eliminate phlegm and relieve cough and detoxify. The roasted qi-tonifying and urgent-relieving force is strong; it can purge fire and detoxify.
Cinnamon: pungent, sweet and hot in nature. It enters kidney, spleen and heart-liver meridians. Cinnamon is pungent, sweet and warm in nature, and has effects of warming and invigorating qi, dispersing, and strengthening yang. Enters the kidney meridian, and nourishes kidney yang to strengthen fire and strengthen yang or to lead fire to return to primordial. Enters the liver, heart and spleen meridians, dispels cold and relieves pain due to cold sinking and cold, warms and dredges meridians to activate blood and dissipate blood stasis. For yang failing to support and support aconite, it is usually not used for restoring yang and rescuing adverse qi. It is a key herb for tonifying fire and invigorating yang, and is good at tonifying yang and yin, relieving and tonifying kidney yang and inducing fire to return to the original position; it is indicated for blood stasis with cold because it enters blood system and is good at warming and activating meridians and improving microcirculation.
Poria cocos: sweet and bland in property and flat. It enters heart, lung, spleen and kidney meridians. Poria, poria cocos, radix et rhizoma Rhei, and Poria cocos, are sweet and light in nature, good in spleen and kidney meridians, and capable of excreting dampness and promoting diuresis to remove water retention, and invigorating spleen to promote water dampness transportation and transformation; it is indicated for heart meridian entered, heart-soothing and tranquillizing, and water-qi-flowing and heart-qi-flowing. It is good at treating edema due to spleen deficiency or excessive dampness, because it is indicated for water-damp and fluid retention, both cold and heat and spleen deficiency.
Compared with the prior art, the invention has the beneficial effects that:
The traditional Chinese medicine considers that one of the pathogenesis of varicocele is liver cold, which is caused by cold, congealing of channels and blood circulation after the liver is subjected to cold, because the whole genitals of men belong to the liver channel. The invention takes cassia twig, common fennel fruit and cinnamon as monarch drugs: ramulus Cinnamomi warms and invigorates yang, eliminates cold evil, dredges blood vessels, eliminates cold and relieves exterior syndrome; fennel enters liver meridian, is used for dispelling liver cold, and can dispel cold and promote qi when the medicine property is kept away; cinnamon warms and tonifies kidney yang, fires and returns to the original position, leads yang qi of a patient to lower jiao, acts on an affected part, and can also prevent upper heat and lower cold of the patient. Bupleurum, angelica and white peony root are taken as ministerial drugs: the bupleurum is used for soothing liver and relieving depression, regulating liver qi, causing qi stagnation and blood stasis due to the liver qi depression, aggravating illness, and adding the bupleurum for regulating qi and preventing blood stasis; chinese angelica can nourish liver and nourish blood, enrich blood and promote blood circulation; bai Shao has the actions of soothing liver and nourishing yin, and also can astringe liver fire. Fructus evodiae, poria cocos and liquorice are used as adjuvant drugs: fructus evodiae is good at dispelling cold of liver meridian, but has strong drug property, so that only a small amount of fructus evodiae is used to prevent severe cold coagulation; poria removes dampness, prevents cold dampness in the body of a patient; licorice root, radix Glycyrrhizae Praeparata regulates the drugs. The monarch drug in the invention warms channels, dissipates cold, the ministerial drug activates blood, warms and removes obstruction, and has the effects of liver softening, yin nourishing, and the adjuvant and guide drug assists the monarch drug to further achieve better effects; monarch, minister, assistant and guide, synergistic effect and inedible.
Detailed Description
The following description of the embodiments of the present invention will be made in detail, but not necessarily with reference to the specific embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The methods described in the various embodiments of the present invention, unless otherwise specified, are all conventional. The materials, reagents and the like used, unless otherwise specified, are all commercially available.
Example 1
The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10 parts of cassia twig, 20 parts of common fennel, 15 parts of radix bupleuri, 8 parts of Chinese angelica, 2 parts of fructus evodiae, 4 parts of white peony root, 5 parts of liquorice, 16 parts of cinnamon and 9 parts of poria cocos.
The preparation method of the traditional Chinese medicine composition specifically comprises the following steps:
preparing a fennel extract: pulverizing fructus Foeniculi to 100 mesh, bagging with gauze, decocting in water at 95deg.C for 30min, and filtering with 200 mesh gauze to obtain fructus Foeniculi extractive solution; the mass ratio of the fennel to the water is 1:6.
Preparing a poria cocos extracting solution: cutting Poria into pieces with thickness of 1mm, adding 95% ethanol, refluxing at 75deg.C for 1 hr, and filtering with 100 mesh gauze to obtain Poria extractive solution; the mass ratio of the poria cocos to the 95% ethanol is 1:10.
Preparing a cassia twig extracting solution: cutting ramulus Cinnamomi into pieces with thickness of 1mm, adding 95% ethanol, refluxing at 75deg.C for 1 hr, and filtering with 100 mesh gauze to obtain ramulus Cinnamomi extractive solution; the mass ratio of the cassia twig to the 95% ethanol is 1:10.
Preparing bupleurum extracting solution: cutting bupleuri radix into pieces with thickness of 1mm, refluxing with 95% ethanol at 75deg.C for 1 hr, and filtering with 100 mesh gauze to obtain bupleuri radix extractive solution; the mass ratio of the bupleurum to the 95% ethanol is 1:10.
Preparing an angelica extract: cutting radix Angelicae sinensis into pieces with thickness of 1mm, adding 95% ethanol, refluxing at 75deg.C for 1 hr, and filtering with 100 mesh gauze to obtain radix Angelicae sinensis extractive solution; the mass ratio of the angelica to the 95% ethanol is 1:10.
Preparing white peony root extract: cutting radix Paeoniae alba into pieces with thickness of 1mm, adding 95% ethanol, refluxing at 75deg.C for 1 hr, and filtering with 100 mesh gauze to obtain radix Paeoniae alba extractive solution; the mass ratio of the white paeony root to the 95% ethanol is 1:10.
Preparing licorice extract: cutting Glycyrrhrizae radix into pieces with thickness of 1mm, adding 95% ethanol, refluxing at 75deg.C for 1 hr, and filtering with 100 mesh gauze to obtain Glycyrrhrizae radix extractive solution; the mass ratio of the liquorice to the 95% ethanol is 1:10.
Preparing cinnamon extract: cutting cortex Cinnamomi into pieces with thickness of 1mm, adding 95% ethanol, refluxing at 75deg.C for 1 hr, and filtering with 100 mesh gauze to obtain cortex Cinnamomi extractive solution; the mass ratio of the cinnamon to the 95% ethanol is 1:10.
Mixing the obtained fructus Foeniculi extract, poria extract, ramulus Cinnamomi extract, bupleuri radix extract, radix Angelicae sinensis extract, radix Paeoniae alba extract, glycyrrhrizae radix extract, and cortex Cinnamomi extract to obtain mixed extract;
Preparing a traditional Chinese medicine composition: soaking fructus evodiae in the mixed extractive solution for 1 hr, refluxing for 45min, filtering with 100 mesh gauze, and removing solvent to obtain the Chinese medicinal composition.
Example 2
The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 14 parts of cassia twig, 23 parts of common fennel, 20 parts of radix bupleuri, 10 parts of Chinese angelica, 3 parts of evodia rutaecarpa, 6 parts of white peony root, 6 parts of liquorice, 20 parts of cinnamon and 12 parts of poria cocos.
The preparation method of the traditional Chinese medicine composition specifically comprises the following steps:
Preparing a fennel extract: pulverizing fructus Foeniculi to 100 mesh, bagging with gauze, decocting in water at 96 deg.C for 35min, and filtering with 200 mesh gauze to obtain fructus Foeniculi extractive solution; the mass ratio of the fennel to the water is 1:6.
Preparing a poria cocos extracting solution: cutting Poria into pieces with thickness of 1mm, adding 95% ethanol, refluxing at 75deg.C for 1 hr, and filtering with 100 mesh gauze to obtain Poria extractive solution; the mass ratio of the poria cocos to the 95% ethanol is 1:10.
Preparing a cassia twig extracting solution: cutting ramulus Cinnamomi into pieces with thickness of 1mm, adding 95% ethanol, refluxing at 75deg.C for 1 hr, and filtering with 100 mesh gauze to obtain ramulus Cinnamomi extractive solution; the mass ratio of the cassia twig to the 95% ethanol is 1:10.
Preparing bupleurum extracting solution: cutting bupleuri radix into pieces with thickness of 1mm, refluxing with 95% ethanol at 75deg.C for 1 hr, and filtering with 100 mesh gauze to obtain bupleuri radix extractive solution; the mass ratio of the bupleurum to the 95% ethanol is 1:10.
Preparing an angelica extract: cutting radix Angelicae sinensis into pieces with thickness of 1mm, adding 95% ethanol, refluxing at 75deg.C for 1 hr, and filtering with 100 mesh gauze to obtain radix Angelicae sinensis extractive solution; the mass ratio of the angelica to the 95% ethanol is 1:10.
Preparing white peony root extract: cutting radix Paeoniae alba into pieces with thickness of 1mm, adding 95% ethanol, refluxing at 75deg.C for 1 hr, and filtering with 100 mesh gauze to obtain radix Paeoniae alba extractive solution; the mass ratio of the white paeony root to the 95% ethanol is 1:10.
Preparing licorice extract: cutting Glycyrrhrizae radix into pieces with thickness of 1mm, adding 95% ethanol, refluxing at 75deg.C for 1 hr, and filtering with 100 mesh gauze to obtain Glycyrrhrizae radix extractive solution; the mass ratio of the liquorice to the 95% ethanol is 1:10.
Preparing cinnamon extract: cutting cortex Cinnamomi into pieces with thickness of 1mm, adding 95% ethanol, refluxing at 75deg.C for 1 hr, and filtering with 100 mesh gauze to obtain cortex Cinnamomi extractive solution; the mass ratio of the cinnamon to the 95% ethanol is 1:10.
Mixing the obtained fructus Foeniculi extract, poria extract, ramulus Cinnamomi extract, bupleuri radix extract, radix Angelicae sinensis extract, radix Paeoniae alba extract, glycyrrhrizae radix extract, and cortex Cinnamomi extract to obtain mixed extract;
Preparing a traditional Chinese medicine composition: soaking fructus evodiae in the mixed extractive solution for 1 hr, refluxing for 50min, filtering with 100 mesh gauze, and removing solvent to obtain the Chinese medicinal composition.
Example 3
The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15 parts of cassia twig, 25 parts of common fennel, 23 parts of radix bupleuri, 12 parts of Chinese angelica, 3 parts of evodia rutaecarpa, 7 parts of white peony root, 7 parts of liquorice, 21 parts of cinnamon and 13 parts of poria cocos.
The preparation method of the traditional Chinese medicine composition specifically comprises the following steps:
Preparing a fennel extract: pulverizing fructus Foeniculi to 200 mesh, bagging with gauze, decocting in water at 97deg.C for 40min, and filtering with 200 mesh gauze to obtain fructus Foeniculi extractive solution; the mass ratio of the fennel to the water is 1:7.
Preparing a poria cocos extracting solution: cutting Poria into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain Poria extractive solution; the mass ratio of the poria cocos to the 95% ethanol is 1:11.
Preparing a cassia twig extracting solution: cutting ramulus Cinnamomi into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain ramulus Cinnamomi extractive solution; the mass ratio of the cassia twig to the 95% ethanol is 1:11.
Preparing bupleurum extracting solution: cutting bupleuri radix into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain bupleuri radix extractive solution; the mass ratio of the bupleurum to the 95% ethanol is 1:11.
Preparing an angelica extract: cutting radix Angelicae sinensis into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain radix Angelicae sinensis extractive solution; the mass ratio of the angelica to the 95% ethanol is 1:11.
Preparing white peony root extract: cutting radix Paeoniae alba into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain radix Paeoniae alba extractive solution; the mass ratio of the white paeony root to the 95% ethanol is 1:11.
Preparing licorice extract: cutting Glycyrrhrizae radix into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain Glycyrrhrizae radix extractive solution; the mass ratio of the liquorice to the 95% ethanol is 1:11.
Preparing cinnamon extract: cutting cortex Cinnamomi into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain cortex Cinnamomi extractive solution; the mass ratio of the cinnamon to the 95% ethanol is 1:11.
Mixing the obtained fructus Foeniculi extract, poria extract, ramulus Cinnamomi extract, bupleuri radix extract, radix Angelicae sinensis extract, radix Paeoniae alba extract, glycyrrhrizae radix extract, and cortex Cinnamomi extract to obtain mixed extract;
Preparing a traditional Chinese medicine composition: soaking fructus evodiae in the mixed extractive solution for 1 hr, refluxing for 55min, filtering with 100 mesh gauze, and removing solvent to obtain the Chinese medicinal composition.
Example 4
The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 16 parts of cassia twig, 27 parts of common fennel, 25 parts of radix bupleuri, 13 parts of Chinese angelica, 4 parts of evodia rutaecarpa, 8 parts of white peony root, 8 parts of liquorice, 22 parts of cinnamon and 14 parts of poria cocos.
The preparation method of the traditional Chinese medicine composition specifically comprises the following steps:
preparing a fennel extract: pulverizing fructus Foeniculi to 200 mesh, bagging with gauze, decocting in water at 98deg.C for 45min, and filtering with 200 mesh gauze to obtain fructus Foeniculi extractive solution; the mass ratio of the fennel to the water is 1:8.
Preparing a poria cocos extracting solution: cutting Poria into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 75deg.C for 2 hr, and filtering with 100 mesh gauze to obtain Poria extractive solution; the mass ratio of the poria cocos to the 95% ethanol is 1:12.
Preparing a cassia twig extracting solution: cutting ramulus Cinnamomi into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 75deg.C for 2 hr, and filtering with 100 mesh gauze to obtain ramulus Cinnamomi extractive solution; the mass ratio of the cassia twig to the 95% ethanol is 1:12.
Preparing bupleurum extracting solution: cutting bupleuri radix into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 75deg.C for 2 hr, and filtering with 100 mesh gauze to obtain bupleuri radix extractive solution; the mass ratio of the bupleurum to the 95% ethanol is 1:12.
Preparing an angelica extract: cutting radix Angelicae sinensis into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 75deg.C for 2 hr, and filtering with 100 mesh gauze to obtain radix Angelicae sinensis extractive solution; the mass ratio of the angelica to the 95% ethanol is 1:12.
Preparing white peony root extract: cutting radix Paeoniae alba into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 75deg.C for 2 hr, and filtering with 100 mesh gauze to obtain radix Paeoniae alba extractive solution; the mass ratio of the white paeony root to the 95% ethanol is 1:12.
Preparing licorice extract: cutting Glycyrrhrizae radix into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 75deg.C for 2 hr, and filtering with 100 mesh gauze to obtain Glycyrrhrizae radix extractive solution; the mass ratio of the liquorice to the 95% ethanol is 1:12.
Preparing cinnamon extract: cutting cortex Cinnamomi into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 75deg.C for 2 hr, and filtering with 100 mesh gauze to obtain cortex Cinnamomi extractive solution; the mass ratio of the cinnamon to the 95% ethanol is 1:12.
Mixing the obtained fructus Foeniculi extract, poria extract, ramulus Cinnamomi extract, bupleuri radix extract, radix Angelicae sinensis extract, radix Paeoniae alba extract, glycyrrhrizae radix extract, and cortex Cinnamomi extract to obtain mixed extract;
preparing a traditional Chinese medicine composition: soaking fructus evodiae in the mixed extractive solution for 1.5 hr, refluxing for 60min, filtering with 100 mesh gauze, and removing solvent to obtain the Chinese medicinal composition.
Example 5
The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20 parts of cassia twig, 30 parts of common fennel, 30 parts of radix bupleuri, 15 parts of Chinese angelica, 5 parts of fructus evodiae, 10 parts of white peony root, 10 parts of liquorice, 26 parts of cinnamon and 17 parts of poria cocos.
The preparation method of the traditional Chinese medicine composition specifically comprises the following steps:
Preparing a fennel extract: pulverizing fructus Foeniculi to 200 mesh, bagging with gauze, decocting in water at 100deg.C for 45min, and filtering with 200 mesh gauze to obtain fructus Foeniculi extractive solution; the mass ratio of the fennel to the water is 1:8.
Preparing a poria cocos extracting solution: cutting Poria into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 75deg.C for 2 hr, and filtering with 100 mesh gauze to obtain Poria extractive solution; the mass ratio of the poria cocos to the 95% ethanol is 1:12.
Preparing a cassia twig extracting solution: cutting ramulus Cinnamomi into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 75deg.C for 2 hr, and filtering with 100 mesh gauze to obtain ramulus Cinnamomi extractive solution; the mass ratio of the cassia twig to the 95% ethanol is 1:12.
Preparing bupleurum extracting solution: cutting bupleuri radix into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 75deg.C for 2 hr, and filtering with 100 mesh gauze to obtain bupleuri radix extractive solution; the mass ratio of the bupleurum to the 95% ethanol is 1:12.
Preparing an angelica extract: cutting radix Angelicae sinensis into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 75deg.C for 2 hr, and filtering with 100 mesh gauze to obtain radix Angelicae sinensis extractive solution; the mass ratio of the angelica to the 95% ethanol is 1:12.
Preparing white peony root extract: cutting radix Paeoniae alba into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 75deg.C for 2 hr, and filtering with 100 mesh gauze to obtain radix Paeoniae alba extractive solution; the mass ratio of the white paeony root to the 95% ethanol is 1:12.
Preparing licorice extract: cutting Glycyrrhrizae radix into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 75deg.C for 2 hr, and filtering with 100 mesh gauze to obtain Glycyrrhrizae radix extractive solution; the mass ratio of the liquorice to the 95% ethanol is 1:12.
Preparing cinnamon extract: cutting cortex Cinnamomi into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 75deg.C for 2 hr, and filtering with 100 mesh gauze to obtain cortex Cinnamomi extractive solution; the mass ratio of the cinnamon to the 95% ethanol is 1:12.
Mixing the obtained fructus Foeniculi extract, poria extract, ramulus Cinnamomi extract, bupleuri radix extract, radix Angelicae sinensis extract, radix Paeoniae alba extract, glycyrrhrizae radix extract, and cortex Cinnamomi extract to obtain mixed extract;
preparing a traditional Chinese medicine composition: soaking fructus evodiae in the mixed extractive solution for 1.5 hr, refluxing for 60min, filtering with 100 mesh gauze, and removing solvent to obtain the Chinese medicinal composition.
Comparative example 1 (no monarch drug)
The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 23 parts of bupleurum, 12 parts of angelica, 3 parts of evodia rutaecarpa, 7 parts of white peony root, 7 parts of liquorice and 13 parts of poria cocos.
The preparation method of the traditional Chinese medicine composition specifically comprises the following steps:
Preparing a poria cocos extracting solution: cutting Poria into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain Poria extractive solution; the mass ratio of the poria cocos to the 95% ethanol is 1:11.
Preparing bupleurum extracting solution: cutting bupleuri radix into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain bupleuri radix extractive solution; the mass ratio of the bupleurum to the 95% ethanol is 1:11.
Preparing an angelica extract: cutting radix Angelicae sinensis into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain radix Angelicae sinensis extractive solution; the mass ratio of the angelica to the 95% ethanol is 1:11.
Preparing white peony root extract: cutting radix Paeoniae alba into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain radix Paeoniae alba extractive solution; the mass ratio of the white paeony root to the 95% ethanol is 1:11.
Preparing licorice extract: cutting Glycyrrhrizae radix into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain Glycyrrhrizae radix extractive solution; the mass ratio of the liquorice to the 95% ethanol is 1:11.
Mixing the prepared Poria extractive solution, bupleuri radix extractive solution, radix Angelicae sinensis extractive solution, radix Paeoniae alba extractive solution, and Glycyrrhrizae radix extractive solution to obtain mixed extractive solution;
Preparing a traditional Chinese medicine composition: soaking fructus evodiae in the mixed extractive solution for 1 hr, refluxing for 55min, filtering with 100 mesh gauze, and removing solvent to obtain the Chinese medicinal composition.
Comparative example 2 (no ministerial drug)
The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15 parts of cassia twig, 25 parts of common fennel, 3 parts of evodia rutaecarpa, 7 parts of liquorice, 21 parts of cinnamon and 13 parts of poria cocos.
The preparation method of the traditional Chinese medicine composition specifically comprises the following steps:
Preparing a fennel extract: pulverizing fructus Foeniculi to 200 mesh, bagging with gauze, decocting in water at 97deg.C for 40min, and filtering with 200 mesh gauze to obtain fructus Foeniculi extractive solution; the mass ratio of the fennel to the water is 1:7.
Preparing a poria cocos extracting solution: cutting Poria into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain Poria extractive solution; the mass ratio of the poria cocos to the 95% ethanol is 1:11.
Preparing a cassia twig extracting solution: cutting ramulus Cinnamomi into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain ramulus Cinnamomi extractive solution; the mass ratio of the cassia twig to the 95% ethanol is 1:11.
Preparing licorice extract: cutting Glycyrrhrizae radix into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain Glycyrrhrizae radix extractive solution; the mass ratio of the liquorice to the 95% ethanol is 1:11.
Preparing cinnamon extract: cutting cortex Cinnamomi into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain cortex Cinnamomi extractive solution; the mass ratio of the cinnamon to the 95% ethanol is 1:11.
Mixing the obtained fructus Foeniculi extract, poria extract, ramulus Cinnamomi extract, medulla Tetrapanacis extract, glycyrrhrizae radix extract, and cortex Cinnamomi extract to obtain mixed extract;
Preparing a traditional Chinese medicine composition: soaking fructus evodiae in the mixed extractive solution for 1 hr, refluxing for 55min, filtering with 100 mesh gauze, and removing solvent to obtain the Chinese medicinal composition.
Comparative example 3 (non-adjuvant drug)
The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15 parts of cassia twig, 25 parts of fennel, 23 parts of radix bupleuri, 12 parts of Chinese angelica, 7 parts of white peony root and 21 parts of cinnamon.
The preparation method of the traditional Chinese medicine composition specifically comprises the following steps:
Preparing a fennel extract: pulverizing fructus Foeniculi to 200 mesh, bagging with gauze, decocting in water at 97deg.C for 40min, and filtering with 200 mesh gauze to obtain fructus Foeniculi extractive solution; the mass ratio of the fennel to the water is 1:7.
Preparing a cassia twig extracting solution: cutting ramulus Cinnamomi into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain ramulus Cinnamomi extractive solution; the mass ratio of the cassia twig to the 95% ethanol is 1:11.
Preparing bupleurum extracting solution: cutting bupleuri radix into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain bupleuri radix extractive solution; the mass ratio of the bupleurum to the 95% ethanol is 1:11.
Preparing an angelica extract: cutting radix Angelicae sinensis into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain radix Angelicae sinensis extractive solution; the mass ratio of the angelica to the 95% ethanol is 1:11.
Preparing white peony root extract: cutting radix Paeoniae alba into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain radix Paeoniae alba extractive solution; the mass ratio of the white paeony root to the 95% ethanol is 1:11.
Preparing cinnamon extract: cutting cortex Cinnamomi into pieces with thickness of 2mm, adding 95% ethanol, refluxing at 74 deg.C for 1.5 hr, and filtering with 100 mesh gauze to obtain cortex Cinnamomi extractive solution; the mass ratio of the cinnamon to the 95% ethanol is 1:11.
Mixing the prepared fructus Foeniculi extract, poria extract, ramulus Cinnamomi extract, bupleuri radix extract, radix Angelicae sinensis extract, medulla Tetrapanacis extract, radix Paeoniae alba extract, glycyrrhrizae radix extract, and cortex Cinnamomi extract, and removing solvent to obtain the final product.
1. Diagnostic criteria
Class III: when a patient stands up, the patient can see that the dilated vein is exposed on the scrotum skin, such as the lumbricus, and the patient can easily touch the dilated vein;
stage II: the dilated vein is very accessible but not visible at the clinic;
stage I: palpation is not obvious, but can occur when Valsalva is tested;
level 0: palpation is not obvious and Valsalva does not appear in the test.
480 Varicocele patients were diagnosed according to the above diagnostic criteria, randomly divided into 8 groups of 60 persons each. Patients of different groups are respectively taken the traditional Chinese medicine compositions prepared in the examples 1-5 and the traditional Chinese medicine compositions prepared in the comparative examples 1-3, and the traditional Chinese medicine compositions are respectively mixed with warm water to 300mL each time in the morning and evening, and each treatment course is 7 days, and the traditional Chinese medicine compositions are taken for 2 treatment courses to take effect later.
2. Therapeutic effect judgment criterion
And (3) curing: the venous mass of the scrotum internal varicose disappears and the symptoms disappear.
The method is effective: the varicose vein inside the scrotum is relieved and the symptoms are improved.
Invalidation: after 2 treatment courses, the varicose vein inside the scrotum is unchanged or aggravated, and the symptoms are not reduced.
The therapeutic effects of the different groups are shown in Table 1.
Table 1 statistics of treatment results for different groups
Note that: total effective rate = cure rate + effective rate.
As is clear from Table 1, compared with examples 1 to 5, the traditional Chinese medicine composition of comparative example 1 is free of monarch drug, and the cure rate, effective rate and total effective rate of comparative example 1 are far lower than those of examples 1 to 5, which indicates that monarch drug plays a very important role in the traditional Chinese medicine composition of the invention. Compared with examples 1-5, no ministerial drug is added in the traditional Chinese medicine composition of comparative example 2, and the cure rate, the effective rate and the total effective rate of comparative example 2 are slightly higher than those of comparative example 1, but still far lower than those of examples 1-5, which indicates that the ministerial drug is indispensable in the traditional Chinese medicine composition of the invention. Compared with examples 1-5, the traditional Chinese medicine composition of comparative example 3 is not added with an adjuvant, and the cure rate, the effective rate and the total effective rate of comparative example 3 are lower than those of examples 1-5, which shows that the adjuvant can play better roles in cooperation with monarch drugs and ministerial drugs in the traditional Chinese medicine composition of the invention. Therefore, the Chinese medicinal composition prepared by the invention has monarch, minister, assistant and guide, synergistic effect and inedible property.
While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. It is therefore intended that the following claims be interpreted as including the preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (10)
1. The traditional Chinese medicine composition is characterized by comprising the following raw materials in parts by weight: 10-20 parts of cassia twig, 20-30 parts of fennel, 15-30 parts of radix bupleuri, 8-15 parts of angelica, 2-5 parts of evodia rutaecarpa, 4-10 parts of white peony root, 5-10 parts of liquorice, 16-26 parts of cinnamon and 9-17 parts of poria cocos.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 14-16 parts of cassia twig, 23-27 parts of fennel, 20-25 parts of radix bupleuri, 10-13 parts of angelica, 3-4 parts of evodia rutaecarpa, 6-8 parts of white peony root, 6-8 parts of liquorice, 20-22 parts of cinnamon and 12-14 parts of poria cocos.
3. The traditional Chinese medicine composition is characterized by comprising the following raw materials in parts by weight: 15 parts of cassia twig, 25 parts of common fennel, 23 parts of radix bupleuri, 12 parts of Chinese angelica, 3 parts of evodia rutaecarpa, 7 parts of white peony root, 7 parts of liquorice, 21 parts of cinnamon and 13 parts of poria cocos.
4. A method for preparing a traditional Chinese medicine composition according to claims 1-3, characterized in that it comprises the following steps:
preparing a fennel extract: pulverizing fructus Foeniculi, bagging, decocting in water for 30-45 min, and filtering to obtain fructus Foeniculi extractive solution;
preparing a poria cocos extracting solution: slicing poria cocos, refluxing ethanol for 1-2 h, and filtering to obtain poria cocos extract;
the method for preparing the cassia twig extract, the bupleurum extract, the angelica extract, the white peony root extract, the liquorice extract and the cinnamon extract is the same as the method for preparing the poria extract;
mixing the obtained fructus Foeniculi extract, poria extract, ramulus Cinnamomi extract, bupleuri radix extract, radix Angelicae sinensis extract, radix Paeoniae alba extract, glycyrrhrizae radix extract, and cortex Cinnamomi extract to obtain mixed extract;
preparing a traditional Chinese medicine composition: soaking evodia rutaecarpa in the mixed extracting solution for 1-1.5 h, refluxing for 45-60 min, filtering and removing the solvent to obtain the traditional Chinese medicine composition.
5. The method of preparing a Chinese medicinal composition according to claim 4, wherein the fennel is crushed to 100-200 mesh when preparing the fennel extract.
6. The method for preparing a Chinese medicinal composition according to claim 5, wherein the mass ratio of the fennel to the water is 1:6-8 when preparing the fennel extract.
7. The method according to claim 4, wherein the Poria cocos is sliced to a thickness of 1-2 mm when the Poria cocos extract is prepared.
8. The method for preparing a pharmaceutical composition according to claim 7, wherein the mass ratio of Poria cocos to ethanol is 1:10-12.
9. Use of the Chinese medicinal composition according to claim 1 in the preparation of a medicament for treating varicocele.
10. The use according to claim 9, wherein the varicocele is a liver-cold induced varicocele.
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