CN118027678A - Silicone rubber material, preparation method thereof and application thereof in preparation of medical negative pressure wound repair product - Google Patents
Silicone rubber material, preparation method thereof and application thereof in preparation of medical negative pressure wound repair product Download PDFInfo
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- CN118027678A CN118027678A CN202410437269.XA CN202410437269A CN118027678A CN 118027678 A CN118027678 A CN 118027678A CN 202410437269 A CN202410437269 A CN 202410437269A CN 118027678 A CN118027678 A CN 118027678A
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- 229920002379 silicone rubber Polymers 0.000 title claims abstract description 46
- 239000004945 silicone rubber Substances 0.000 title claims abstract description 40
- 239000000463 material Substances 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims description 30
- 230000037314 wound repair Effects 0.000 title claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 118
- 239000005543 nano-size silicon particle Substances 0.000 claims abstract description 58
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 58
- 239000003607 modifier Substances 0.000 claims abstract description 32
- 239000002994 raw material Substances 0.000 claims abstract description 22
- 239000000945 filler Substances 0.000 claims abstract description 18
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 11
- 229920001661 Chitosan Polymers 0.000 claims abstract description 10
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 10
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 10
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 40
- 238000000498 ball milling Methods 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 20
- 235000019359 magnesium stearate Nutrition 0.000 claims description 20
- 239000003795 chemical substances by application Substances 0.000 claims description 18
- 230000004048 modification Effects 0.000 claims description 13
- 238000012986 modification Methods 0.000 claims description 13
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 12
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 12
- 239000004115 Sodium Silicate Substances 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 12
- 235000010413 sodium alginate Nutrition 0.000 claims description 12
- 239000000661 sodium alginate Substances 0.000 claims description 12
- 229940005550 sodium alginate Drugs 0.000 claims description 12
- 239000001509 sodium citrate Substances 0.000 claims description 12
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 12
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 12
- 229910052911 sodium silicate Inorganic materials 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 235000021355 Stearic acid Nutrition 0.000 claims description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 6
- 239000004202 carbamide Substances 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims description 6
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 6
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 6
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims description 6
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims description 6
- 239000008117 stearic acid Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 abstract description 14
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 13
- 239000011787 zinc oxide Substances 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 4
- 229920002529 medical grade silicone Polymers 0.000 abstract description 4
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 6
- NOZAQBYNLKNDRT-UHFFFAOYSA-N [diacetyloxy(ethenyl)silyl] acetate Chemical compound CC(=O)O[Si](OC(C)=O)(OC(C)=O)C=C NOZAQBYNLKNDRT-UHFFFAOYSA-N 0.000 description 2
- QYLFHLNFIHBCPR-UHFFFAOYSA-N 1-ethynylcyclohexan-1-ol Chemical compound C#CC1(O)CCCCC1 QYLFHLNFIHBCPR-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
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- Compositions Of Macromolecular Compounds (AREA)
Abstract
The invention relates to the technical field of wound materials, and in particular discloses a silicone rubber material which comprises the following raw materials in parts by weight: 25-30 parts of medical silicon rubber, 6-10 parts of nano silicon dioxide modifier, 4-6 parts of filler auxiliary agent, 2-4 parts of polyvinyl alcohol and 1-3 parts of chitosan. The silicone rubber material adopts medical silicone rubber and zinc oxide to improve the antibacterial performance of the product, enhances the functional effect of the product by adding a filler additive, enhances the antibacterial durability of the product by adopting a nano silicon dioxide modifier, optimizes the toughness performance of the product, and realizes the coordinated improvement of the antibacterial durability, the toughness performance and the transparency of the product.
Description
Technical Field
The invention relates to the technical field of wound materials, in particular to a silicone rubber material, a preparation method thereof and application thereof in preparing a medical negative pressure wound repair product.
Background
The existing material for the medical negative pressure wound surface has poor antibacterial performance, meanwhile, the antibacterial performance is not durable, the antibacterial stability is not durable under the friction condition, and in order to improve the antibacterial performance, the toughness performance of the product is poor, and the coordinated improvement of the antibacterial stability and the toughness performance of the product is difficult to realize.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a silicone rubber material, a preparation method thereof and application thereof in preparing a medical negative pressure wound repair product so as to solve the problems in the prior art.
The invention solves the technical problems by adopting the following technical scheme:
the invention provides a silicone rubber material which comprises the following raw materials in parts by weight:
25-30 parts of medical silicon rubber, 6-10 parts of nano silicon dioxide modifier, 4-6 parts of filler auxiliary agent, 2-4 parts of polyvinyl alcohol and 1-3 parts of chitosan.
The medical silicone rubber can be conventional medical silicone rubber obtained through market purchase; silicone rubber consisting of a component a containing a casteplatinum catalyst and a component B containing a cross-linking agent hydrogen-containing silicone oil and an inhibitor ethynyl cyclohexanol may also be used.
Preferably, the silicone rubber material comprises the following raw materials in parts by weight:
27.5 parts of medical silicon rubber, 8 parts of nano silicon dioxide modifier, 5 parts of filler auxiliary agent, 3 parts of polyvinyl alcohol and 2 parts of chitosan.
Preferably, the filler aid is stearic acid; the silicone rubber material also includes 2 parts of vinyl triacetoxy silane.
Preferably, the preparation method of the nano silicon dioxide modifier comprises the following steps:
s01: the nano silicon dioxide is firstly heat treated for 10-15min at 130-135 ℃, then cooled to 55-60 ℃ at the speed of 2-5 ℃/min, and the heat is preserved, thus obtaining the heat-improved nano silicon dioxide agent;
s02: carrying out ultrasonic modification treatment on the thermally improved nano silicon dioxide agent and the modifying liquid according to the weight ratio of 2:5, and washing and drying after the treatment is finished to obtain a modified nano silicon dioxide body;
s03: 3-5 parts of magnesium stearate, 1-2 parts of nano silica sol, 4-7 parts of sodium citrate solution and 1-2 parts of urea are stirred and uniformly mixed to obtain a magnesium stearate agent;
S04: ball milling the modified nano silicon dioxide body and the magnesium stearate according to the weight ratio of 3:1, wherein the ball milling rotating speed is 1000-1500r/min, ball milling is carried out for 1-2h, and after ball milling, water washing and drying are carried out, so as to obtain the nano silicon dioxide modifier.
Preferably, the mass fraction of the sodium citrate solution is 1-3%; the ultrasonic power of the ultrasonic modification treatment is 350-400W, and the ultrasonic time is 1-2h.
Preferably, the preparation method of the modified liquid comprises the following steps:
Adding 2-4 parts of sodium dodecyl benzene sulfonate and 1-2 parts of glycolic acid into 4-7 parts of sodium silicate solution, then adding 1-3 parts of sodium alginate solution, and stirring and uniformly mixing to obtain modified liquid.
Preferably, the mass fraction of the sodium silicate solution is 10-15%; the mass fraction of the sodium alginate solution is 2-5%.
The invention also provides a preparation method of the silicone rubber material, which comprises the following steps:
Step one, weighing raw materials according to parts by weight:
sequentially adding the raw materials into an internal mixer for banburying at 130-140 ℃ for 5-10min;
and thirdly, vulcanizing at 170 ℃ for 10-20min, and cooling to obtain the silicone rubber material.
Compared with the prior art, the invention has the following beneficial effects:
The silicone rubber material adopts medical silicone rubber and zinc oxide to improve the antibacterial performance of the product, enhances the functional effect of the product by adding the filler auxiliary agent, enhances the antibacterial durability of the product by adopting the nano silicon dioxide modifier, optimizes the toughness performance of the product, and realizes the coordinated improvement of the antibacterial durability and the toughness performance of the product.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The silicone rubber material of the embodiment comprises the following raw materials in parts by weight:
25-30 parts of medical silicon rubber, 6-10 parts of nano silicon dioxide modifier, 4-6 parts of filler auxiliary agent, 2-4 parts of polyvinyl alcohol, 1-3 parts of chitosan and 0.5-1 part of zinc oxide.
The silicone rubber material of the embodiment comprises the following raw materials in parts by weight:
27.5 parts of medical silicon rubber, 8 parts of nano silicon dioxide modifier, 5 parts of filler auxiliary agent, 3 parts of polyvinyl alcohol, 2 parts of chitosan and 0.75 part of zinc oxide.
The filler aid in this example is stearic acid; the silicone rubber material also includes 2 parts of vinyl triacetoxy silane.
The preparation method of the nano silicon dioxide modifier comprises the following steps:
s01: the nano silicon dioxide is firstly heat treated for 10-15min at 130-135 ℃, then cooled to 55-60 ℃ at the speed of 2-5 ℃/min, and the heat is preserved, thus obtaining the heat-improved nano silicon dioxide agent;
s02: carrying out ultrasonic modification treatment on the thermally improved nano silicon dioxide agent and the modifying liquid according to the weight ratio of 2:5, and washing and drying after the treatment is finished to obtain a modified nano silicon dioxide body;
s03: 3-5 parts of magnesium stearate, 1-2 parts of nano silica sol, 4-7 parts of sodium citrate solution and 1-2 parts of urea are stirred and uniformly mixed to obtain a magnesium stearate agent;
S04: ball milling the modified nano silicon dioxide body and the magnesium stearate according to the weight ratio of 3:1, wherein the ball milling rotating speed is 1000-1500r/min, ball milling is carried out for 1-2h, and after ball milling, water washing and drying are carried out, so as to obtain the nano silicon dioxide modifier.
The mass fraction of the sodium citrate solution in the embodiment is 1-3%; the ultrasonic power of the ultrasonic modification treatment is 350-400W, and the ultrasonic time is 1-2h.
The preparation method of the modified liquid in the embodiment comprises the following steps:
Adding 2-4 parts of sodium dodecyl benzene sulfonate and 1-2 parts of glycolic acid into 4-7 parts of sodium silicate solution, then adding 1-3 parts of sodium alginate solution, and stirring and uniformly mixing to obtain modified liquid.
The mass fraction of the sodium silicate solution in the embodiment is 10-15%; the mass fraction of the sodium alginate solution is 2-5%.
The preparation method of the silicone rubber material comprises the following steps:
Step one, weighing raw materials according to parts by weight:
sequentially adding the raw materials into an internal mixer for banburying at 130-140 ℃ for 5-10min;
and thirdly, vulcanizing at 170 ℃ for 10-20min, and cooling to obtain the silicone rubber material.
Example 1.
The silicone rubber material of the embodiment comprises the following raw materials in parts by weight:
25 parts of medical silicon rubber, 6 parts of nano silicon dioxide modifier, 4 parts of filler auxiliary agent, 2 parts of polyvinyl alcohol, 1 part of chitosan and 0.5 part of zinc oxide.
The filler aid of this example is stearic acid.
The preparation method of the nano silicon dioxide modifier in the embodiment comprises the following steps:
s01: the nano silicon dioxide is firstly subjected to heat treatment at 130 ℃ for 10min, then is cooled to 55 ℃ at the speed of 2 ℃/min, and is subjected to heat preservation, so that the thermally improved nano silicon dioxide agent is obtained;
s02: carrying out ultrasonic modification treatment on the thermally improved nano silicon dioxide agent and the modifying liquid according to the weight ratio of 2:5, and washing and drying after the treatment is finished to obtain a modified nano silicon dioxide body;
s03: 3 parts of magnesium stearate, 1 part of nano silica sol, 4 parts of sodium citrate solution and 1 part of urea are stirred and mixed uniformly to obtain a magnesium stearate agent;
S04: ball milling the modified nano silicon dioxide body and the magnesium stearate according to the weight ratio of 3:1, wherein the ball milling rotating speed is 1000r/min, ball milling is carried out for 1h, and after ball milling, water washing and drying are carried out, so that the nano silicon dioxide modifier is obtained.
The mass fraction of the sodium citrate solution of this example was 1%.
The ultrasonic power of the ultrasonic modification treatment of this embodiment is 350W and the ultrasonic time is 1h.
The preparation method of the modified liquid in the embodiment comprises the following steps:
Adding 2 parts of sodium dodecyl benzene sulfonate and 1 part of glycolic acid into 4 parts of sodium silicate solution, then adding 1 part of sodium alginate solution, and stirring and mixing uniformly to obtain a modified liquid.
The mass fraction of the sodium silicate solution of this example was 10%; the mass fraction of the sodium alginate solution is 2%.
The preparation method of the silicone rubber material of the embodiment comprises the following steps:
Step one, weighing raw materials according to parts by weight:
sequentially adding the raw materials into an internal mixer for banburying at 130 ℃ for 5min;
and thirdly, vulcanizing at 170 ℃ for 10min, and cooling to obtain the silicone rubber material.
Example 2.
The silicone rubber material of the embodiment comprises the following raw materials in parts by weight:
30 parts of medical silicon rubber, 10 parts of nano silicon dioxide modifier, 6 parts of filler auxiliary agent, 4 parts of polyvinyl alcohol, 3 parts of chitosan and 1 part of zinc oxide.
The filler aid of this example is stearic acid.
The preparation method of the nano silicon dioxide modifier in the embodiment comprises the following steps:
S01: the nano silicon dioxide is firstly heat treated for 15min at 135 ℃, then cooled to 60 ℃ at the speed of 5 ℃/min, and the heat is preserved, so as to obtain the heat-improved nano silicon dioxide agent;
s02: carrying out ultrasonic modification treatment on the thermally improved nano silicon dioxide agent and the modifying liquid according to the weight ratio of 2:5, and washing and drying after the treatment is finished to obtain a modified nano silicon dioxide body;
s03: stirring and uniformly mixing 5 parts of magnesium stearate, 2 parts of nano silica sol, 7 parts of sodium citrate solution and 2 parts of urea to obtain a magnesium stearate agent;
s04: ball milling the modified nano silicon dioxide body and the magnesium stearate according to the weight ratio of 3:1, wherein the ball milling rotating speed is 1500r/min, ball milling is carried out for 2 hours, and after ball milling, water washing and drying are carried out, so that the nano silicon dioxide modifier is obtained.
The mass fraction of the sodium citrate solution of this example was 3%.
The ultrasonic power of the ultrasonic modification treatment in this embodiment is 400W, and the ultrasonic time is 2h.
The preparation method of the modified liquid in the embodiment comprises the following steps:
Adding 4 parts of sodium dodecyl benzene sulfonate and 2 parts of glycolic acid into 7 parts of sodium silicate solution, then adding 3 parts of sodium alginate solution, and stirring and uniformly mixing to obtain a modified liquid.
The mass fraction of the sodium silicate solution of this example was 15%; the mass fraction of the sodium alginate solution is 5%.
The preparation method of the silicone rubber material of the embodiment comprises the following steps:
Step one, weighing raw materials according to parts by weight:
Sequentially adding the raw materials into an internal mixer for banburying at 140 ℃ for 10min;
And thirdly, vulcanizing at 170 ℃ for 20min, and cooling to obtain the silicone rubber material.
Example 3.
The silicone rubber material of the embodiment comprises the following raw materials in parts by weight:
27.5 parts of medical silicon rubber, 8 parts of nano silicon dioxide modifier, 5 parts of filler auxiliary agent, 3 parts of polyvinyl alcohol, 2 parts of chitosan and 0.75 part of zinc oxide.
The filler aid of this example is stearic acid.
The preparation method of the nano silicon dioxide modifier in the embodiment comprises the following steps:
s01: the nano silicon dioxide is firstly heat treated for 12.5min at 132 ℃, then cooled to 57 ℃ at the speed of 3.5 ℃/min, and the heat is preserved, so as to obtain the heat-improved nano silicon dioxide agent;
s02: carrying out ultrasonic modification treatment on the thermally improved nano silicon dioxide agent and the modifying liquid according to the weight ratio of 2:5, and washing and drying after the treatment is finished to obtain a modified nano silicon dioxide body;
S03: uniformly stirring and mixing 4 parts of magnesium stearate, 1.5 parts of nano silica sol, 5.5 parts of sodium citrate solution and 1.5 parts of urea to obtain a magnesium stearate agent;
S04: ball milling the modified nano silicon dioxide body and the magnesium stearate according to the weight ratio of 3:1, wherein the ball milling rotating speed is 1250r/min, ball milling is carried out for 1.5h, and after ball milling, water washing and drying are carried out, so as to obtain the nano silicon dioxide modifier.
The mass fraction of the sodium citrate solution of this example was 2%.
The ultrasonic power of the ultrasonic modification treatment of this example was 375W and the ultrasonic time was 1.5h.
The preparation method of the modified liquid in the embodiment comprises the following steps:
3 parts of sodium dodecyl benzene sulfonate and 1.5 parts of glycolic acid are added into 5.5 parts of sodium silicate solution, then 2 parts of sodium alginate solution is added, and the mixture is stirred and mixed uniformly to obtain modified liquid.
The mass fraction of the sodium silicate solution of this example was 12.5%; the mass fraction of the sodium alginate solution is 3.5%.
The preparation method of the silicone rubber material of the embodiment comprises the following steps:
Step one, weighing raw materials according to parts by weight:
sequentially adding the raw materials into an internal mixer for banburying at 130-140 ℃ for 5-10min;
and thirdly, vulcanizing at 170 ℃ for 10-20min, and cooling to obtain the silicone rubber material.
Comparative example 1.
The difference from example 3 is that no nanosilica modifier is added.
Comparative example 2.
The difference from example 3 is that no S01 treatment was used in the preparation of the nanosilica modifier.
Comparative example 3.
The difference from example 3 is that no modification liquid treatment is used in the preparation of the nano silica modifier.
Comparative example 4.
The difference from example 3 is that no magnesium stearate treatment was used in the preparation of the nanosilica modifier.
The results of the performance measurements for examples 1-3 and comparative examples 1-4 are as follows
From examples 1-3 and comparative examples 1-4, the product of example 3 of the present invention is excellent in elongation at break, antibacterial stability and transparency, and the prepared product can achieve a coordinated significant improvement in elongation at break, antibacterial stability and transparency;
according to the invention, no nano silicon dioxide modifier is added, so that the performance effect of the product is obviously deteriorated;
The performances of the product which is prepared by the method only have the most obvious performance effect, wherein the product is not treated by S01 in the preparation of the nano silicon dioxide modifier, is not treated by modifying liquid in the preparation of the nano silicon dioxide modifier, and is not treated by magnesium stearate in the preparation of the nano silicon dioxide modifier.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.
Claims (7)
1. The silicone rubber material is characterized by comprising the following raw materials in parts by weight:
25-30 parts of medical silicon rubber, 6-10 parts of nano silicon dioxide modifier, 4-6 parts of filler auxiliary agent, 2-4 parts of polyvinyl alcohol and 1-3 parts of chitosan;
The preparation method of the nano silicon dioxide modifier comprises the following steps:
s01: the nano silicon dioxide is firstly heat treated for 10-15min at 130-135 ℃, then cooled to 55-60 ℃ at the speed of 2-5 ℃/min, and the heat is preserved, thus obtaining the heat-improved nano silicon dioxide agent;
s02: carrying out ultrasonic modification treatment on the thermally improved nano silicon dioxide agent and the modifying liquid according to the weight ratio of 2:5, and washing and drying after the treatment is finished to obtain a modified nano silicon dioxide body;
s03: 3-5 parts of magnesium stearate, 1-2 parts of nano silica sol, 4-7 parts of sodium citrate solution and 1-2 parts of urea are stirred and uniformly mixed to obtain a magnesium stearate agent;
S04: ball milling the modified nano silicon dioxide body and the magnesium stearate according to the weight ratio of 3:1, wherein the ball milling rotating speed is 1000-1500r/min, ball milling is carried out for 1-2h, and after ball milling, water washing and drying are carried out to obtain the nano silicon dioxide modifier; the preparation method of the modified liquid comprises the following steps:
Adding 2-4 parts of sodium dodecyl benzene sulfonate and 1-2 parts of glycolic acid into 4-7 parts of sodium silicate solution, then adding 1-3 parts of sodium alginate solution, and stirring and uniformly mixing to obtain modified liquid.
2. The silicone rubber material according to claim 1, wherein the silicone rubber material comprises the following raw materials in parts by weight:
27.5 parts of medical silicon rubber, 8 parts of nano silicon dioxide modifier, 5 parts of filler auxiliary agent, 3 parts of polyvinyl alcohol and 2 parts of chitosan.
3. A silicone rubber material according to claim 1, wherein the filler aid is stearic acid.
4. The silicone rubber material according to claim 1, wherein the mass fraction of the sodium citrate solution is 1-3%; the ultrasonic power of the ultrasonic modification treatment is 350-400W, and the ultrasonic time is 1-2h.
5. A silicone rubber material according to claim 1, wherein the sodium silicate solution has a mass fraction of 10-15%; the mass fraction of the sodium alginate solution is 2-5%.
6. A method for preparing a silicone rubber material according to any one of claims 1 to 5, comprising the steps of:
Step one, weighing raw materials according to parts by weight:
sequentially adding the raw materials into an internal mixer for banburying at 130-140 ℃ for 5-10min;
and thirdly, vulcanizing at 170 ℃ for 10-20min, and cooling to obtain the silicone rubber material.
7. The use of the silicone rubber material according to any one of claims 1-6 in the preparation of a medical negative pressure wound repair product.
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| CN103965639A (en) * | 2013-01-25 | 2014-08-06 | 圣光医用制品有限公司 | Antibacterial anticoagulant high polymer material, and preparation method and application thereof |
| CN108424654A (en) * | 2018-03-14 | 2018-08-21 | 广州市瑞合新材料科技有限公司 | A kind of food-level antibacterial add-on type liquid silicon rubber and preparation method thereof, silastic product |
| CN113493615A (en) * | 2020-04-07 | 2021-10-12 | 北京化工大学 | Hygroscopic antibacterial silicone rubber composite material and preparation method and application thereof |
| CN114106565A (en) * | 2021-11-19 | 2022-03-01 | 广州市瑞合新材料科技有限公司 | Hydrophilic antibacterial silicone rubber and preparation method and application thereof |
| CN117427481A (en) * | 2023-08-24 | 2024-01-23 | 葫芦岛康达环保工贸有限公司 | Deodorant based on nano silicon dioxide modification and preparation method thereof |
| CN117511047A (en) * | 2023-11-07 | 2024-02-06 | 贵州省纳米材料工程中心 | Antibacterial and mildew-proof polypropylene edible fungus bag film and preparation method thereof |
| CN117736517A (en) * | 2023-11-27 | 2024-03-22 | 广州美村橡胶科技股份有限公司 | Ageing-resistant ethylene propylene diene monomer product and preparation method thereof |
| CN117777602A (en) * | 2024-02-28 | 2024-03-29 | 丹东鑫马高科技塑料包装有限公司 | Degradable plastic master batch and preparation method thereof |
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