CN118022174A - Skin-like large-area self-feedback diagnosis and treatment system - Google Patents
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Abstract
The invention discloses a skin-like large-area self-feedback diagnosis and treatment system which integrates a skin-like surface myoelectrode array module, a myoelectric signal acquisition module and an electric stimulation pulse generation module, wherein the skin-like surface myoelectrode array module can acquire surface myoelectric signals and can perform electric stimulation. The skin-like surface myoelectrode array module has good flexibility and extensibility, can be adhered to skin in a conformal manner, can accurately measure myoelectric signals of a plurality of muscles involved in resting state and exercise in a long-term comfortable, noninvasive and large-area multipoint manner under the condition of matching with the myoelectric signal acquisition module and the electric stimulation pulse generation module, provides possibility for diagnosing and analyzing the conditions of the muscles based on myoelectric information, and simultaneously determines the intensity and the position of electric stimulation according to the obtained myoelectric information and performs accurate electric stimulation treatment so as to optimize the treatment effect.
Description
Technical Field
The invention relates to a skin-like large-area self-feedback diagnosis and treatment system, belonging to the fields of biological surface electromyographic signal acquisition, biological electrical stimulation treatment, biomedical device manufacturing, wearable and extensible flexible electronic devices and mobile medical instruments.
Background
The surface electromyographic signals are the combined effect of the electrical activity on the superficial muscle EMG and the nerve trunk on the skin surface, and the signals are one-dimensional voltage time sequence signals of bioelectrical changes of the neuromuscular system when the neuromuscular system performs voluntary and involuntary activities, and can reflect the activity of the neuromuscular to a certain extent. Along with the increase of the demands of people for health management, the electromyographic signal analysis plays a key role in the technical fields of human body rehabilitation, neuromuscular disease diagnosis and treatment, exercise training, gesture recognition, mobile internet of things and other man-machine interaction. However, the existing myoelectric electrode cannot accurately measure the myoelectric signals of a plurality of muscles involved in resting state and movement in a large-area multipoint manner, so that the flexible high-density surface myoelectric array is extremely a problem to be solved urgently.
The body surface low-frequency electric stimulation is a noninvasive, simple and effective auxiliary treatment method which specifically comprises neuromuscular electric stimulation (NMES), percutaneous nerve electric stimulation (TENS) and the like, and the two treatment modes have shown a certain treatment effect clinically, particularly see A Barikroo.Transcutaneous electrical stimulation and dysphagia rehabilitation:a narrative review[J].Rehabilitation Research and Practice,2020,2020. and A Alamer,H Melese,F Nigussie.Effectiveness of neuromuscular electrical stimulation on post-stroke dysphagia:a systematic review of randomized controlled trials[J].Clinical interventions in aging,2020:1521-1531.., but the existing electric stimulation device generally adopts electrodes with larger area in order to ensure that the body can be fully contacted, the problem that fine electric stimulation cannot be realized due to overlarge electrodes exists, and due to the lack of high-resolution muscle state evaluation information, the integrated position of the electrodes and tissues has a certain randomness, the muscle parts cannot be accurately positioned, the treatment effect is seriously affected, the wearability of the functional electric stimulation system is not strong, the channel number is not enough, and the function is single, so that a skin-like large-area self-feedback diagnosis and treatment system which can form conformal adhesion with the body in operation is needed.
Flexible electronics is an emerging electronics technology that has become a new focus of attention in recent years in the global electronics industry and academia. This technology is mainly to combine inorganic brittle materials with soft elastic substrates to make electronic devices flexible and ductile while maintaining excellent electrical properties. The existing muscle injury diagnosis and treatment system still has the problems of large device quality, low integration level and the like, and is hopeful to develop a muscle diagnosis and treatment system with strong portability and high integration level through the development of flexible electronic technology.
Disclosure of Invention
The invention aims to provide a skin-like large-area self-feedback diagnosis and treatment system, which mainly aims at the defects that the existing muscle diagnosis and treatment system lacks diagnosis and treatment integrated functions, has complex operation, has fewer channels of the existing surface myoelectric electrodes, has insufficient adhesion with skin, cannot obtain high-resolution myoelectric signals of a plurality of muscles, cannot accurately stimulate the muscles of a designated part of the surface electro-stimulation electrodes, and has fewer channels, and can solve the problems including but not limited to: (1) The substrate and the packaging layer of the skin-like surface myoelectrode array module designed and prepared by the invention are made of flexible materials, have good flexibility and extensibility, can be adhered to the skin in a conformal manner, and can accurately measure myoelectric signals of a plurality of muscles involved in resting state and movement in a large-area and multi-point manner; (2) The diagnosis and treatment integrated design is that the current myoelectricity acquisition and electric stimulation treatment is usually two sets of systems, the operation is complicated and inconvenient, and the diagnosis and treatment system designed and prepared by the invention is connected with different functional circuit modules by adopting the electrode design with concentric ring configuration so as to realize the purpose of selecting myoelectricity acquisition or electric stimulation treatment according to the needs; (3) The electrode array designed and prepared by the invention realizes accurate stimulation through a passage formed by each pair of electrodes during electric stimulation treatment by adopting the electrode design with concentric ring configuration; (4) The skin-like large-area self-feedback diagnosis and treatment system designed and prepared by the invention has light weight and high integration, and the skin-like surface myoelectrode array module in the system is made of flexible materials, so that the high-spatial resolution and high-precision myoelectric signals can be comfortably and noninvasively measured for a long time and the electric stimulation treatment can be provided under the guidance of the acquired myoelectric signals.
The invention aims at adopting the following technical scheme:
A skin-like large area self-feedback diagnostic system comprising:
The skin-like surface muscle electrode array module is flexible and stretchable and is used for collecting electric signals and electrically stimulating muscle parts; the skin-like surface muscle electrode array module integrally adopts a sandwich structure, uses flexible materials with strong biocompatibility, adopts a concentric ring structure, and can perform multiple functions such as single-point acquisition, differential acquisition, electric stimulation treatment and the like so as to implement accurate measurement of muscle electrical signals and accurate electric stimulation treatment in a long-term comfortable, noninvasive, large-area and multi-point manner;
The myoelectric signal acquisition module is integrated with an electronic circuit for acquiring the myoelectric signals and is used for receiving the myoelectric signals acquired by the skin-like surface myoelectrode array module and performing data processing; the data processing comprises signal amplification, signal filtering, signal differential acquisition, data presentation, signal drift suppression and AD conversion; the electromyographic signal acquisition module is used for transmitting the processed data to a computer, and the computer analyzes the data and outputs a stimulation scheme, so that the electromyographic signal acquisition module has stronger flexibility and convenience and is more suitable for different application scenes;
And the electric stimulation pulse generation module is used for generating required electric stimulation pulses according to a stimulation scheme output by the computer, amplifying power and transmitting the electric stimulation pulses to the surface muscle electrode array module, and is used for carrying out electric stimulation treatment on muscles and has the functions of constant voltage and constant current control, pulse frequency adjustment, pulse width adjustment, overcurrent protection and overvoltage protection.
In the above technical solution, further, the skin-like surface muscle electrode array module includes N pairs of electrodes, a wire, a substrate, a packaging layer, and a lead interface; the substrate is an intermediate layer, the electrode pairs and the lead interfaces are positioned on the substrate, each lead interface comprises 2N lead ends, each electrode is connected to one lead end of each lead interface through a lead, the packaging layer is arranged on the bottom layer and the top layer of the substrate, and only each electrode pair and each lead interface are exposed.
Further, each pair of electrodes in the skin-like surface muscle electrode array module has 2 electrodes, the structure adopts a concentric ring configuration and is connected by independent wires, and the size, the interval, the mutual interval and the arrangement mode of the electrodes of the electrode pairs are adjusted according to actual requirement conditions.
Further, the lead interface in the skin-like surface myoelectrode array module is connected with other modules in the system through an adapter wire; when the surface electromyographic signal acquisition module is connected with the electromyographic signal acquisition module, surface electromyographic signal acquisition can be performed; when connected with the electric stimulation pulse generation module, the body surface electric stimulation treatment can be performed;
further, the electrodes in the electrode pair in the skin-like surface muscle electrode array module are made of biocompatible conductive materials, such as stretchable conductive silver paste or graphene.
Further, the substrate in the skin-like surface myoelectrode array module is made of a polymer material, such as stretchable polyurethane (TPU) or Polydimethylsiloxane (PDMS).
Further, the packaging layer in the skin-like surface myoelectrode array module adopts a biocompatible polymer material, such as acrylic double faced adhesive tape or medical grade silica gel double faced adhesive tape.
Further, in the skin-like surface muscle electrode array module, a vent hole is formed near each electrode on the substrate in a ring-shaped arrangement.
The skin-like surface myoelectrode array module is prepared by adopting extensible flexible electronic technologies such as a knife coating process, screen printing, a 3D printing mode, a coiled material coating process and the like, and comprises the following specific procedures: preparing a TPU film substrate, preparing a stretchable lead and a myoelectricity recording/stimulating electrode, and packaging a skin-like diagnosis and treatment module.
Further, the electromyographic signal acquisition module includes: an analog-to-digital converter (ADC) module for receiving the electrical signal of the skin-like surface myoelectrode array module and converting the analog signal into a digital signal; a pre-amplifier module for receiving the signal of the analog-to-digital converter (ADC) module and performing preliminary amplification; the switcher module is used for realizing switching between a single-point acquisition mode and a differential acquisition mode so as to adapt to different acquisition requirements; the signal drift suppression circuit module is used for receiving the data processed by the pre-amplifier module and suppressing the signal drift phenomenon through differential amplification and filtering technology; the digital signal processing module is used for receiving the data of the signal drift suppression circuit module and carrying out filtering, noise reduction and feature extraction; the wireless transmission module is used for receiving the data processed by the digital signal processing module and realizing wireless data transmission through a wireless protocol; the data interface module is used for receiving the data processed by the digital signal processing module and transmitting the data to the computer through the wired transmission interface; the power management module ensures stable power supply of other modules; and the micro control module is used for controlling the electromyographic signal acquisition module to work normally.
Further, the electrical stimulation pulse generation module comprises: the control unit module is responsible for controlling and coordinating the whole module and receiving a stimulation scheme input by a computer so as to adjust the electric stimulation parameters; the pulse generation module is used for generating an electric stimulation pulse signal with adjustable frequency and width according to the electric stimulation parameters and adjusting current intensity so as to adapt to muscle treatment requirements of different parts and different damage degrees: the electrode channel adjusting module selects an electrode channel which is conducted according to the electric stimulation parameters so as to directionally stimulate muscles at different positions; the power amplification module is used for amplifying the power of the electric stimulation pulse signals generated by the pulse generation module so as to meet the stimulation requirement of muscle tissues of a patient; the constant voltage and constant current control module is used for keeping the voltage or current of the electric stimulation pulse signal output by the power amplification module constant and ensuring the stability of treatment; the safety cut-off device module automatically cuts off the electric stimulation pulse signal output of the power amplification module when abnormal conditions occur, so that the safety of a patient is ensured; and the micro control module is used for controlling the electric stimulation pulse generation module to work normally.
The diagnosis and treatment method is realized based on the skin-like large-area self-feedback diagnosis and treatment system, and comprises the following steps of:
1) Early preparation: cleaning the surface of human skin with sterilizing alcohol and scrub, filling commercial solid conductive paste (Ten 20, wever, usa) in the exposed part of the skin-like patch muscle electrode and pasting the surface towards the skin, and compacting the device to achieve conformal adhesion with the skin;
2) And (3) signal acquisition: the skin-like surface myoelectrode array module in the system is connected with the myoelectric signal acquisition module, the myoelectric signals generated by muscle parts of a patient are acquired and subjected to preliminary treatment, and the myoelectric signals are transmitted to a computer through the wireless transmission module or the data interface module in the myoelectric signal acquisition module for further treatment and analysis;
3) Signal processing and diagnosis: generating a dynamic RMS cloud image by utilizing the collected muscle electric signals to realize data visualization and intuitively embody the activity condition of muscles; extracting features such as kurtosis, lempel-Ziv complexity, power spectrum peak frequency, power spectrum total power, power spectrum average frequency and the like of the data, performing dimension reduction by using a linear discriminant analysis (LINEAR DISCRIMINANT ANALYSIS) algorithm, establishing a random forest algorithm (Random Forest Algorithm) model, and delivering the dimension-reduced data to the random forest algorithm model so as to obtain diagnosis results of damaged parts and damaged degrees of muscles of patients;
4) Electrical stimulation treatment: the muscle position stimulated during the electric stimulation treatment and the electric stimulation current intensity are determined according to the diagnosis result, a skin-like surface muscle electrode array module in the system is connected with an electric stimulation pulse generation module, and the intensity of the electric stimulation pulse generated by the electric stimulation pulse generation module and the number of conducted channels are set, so that the accurate electric stimulation treatment is realized.
Compared with the traditional muscle diagnosis and treatment system, the invention has the following outstanding advantages and effects: ① Compared with the traditional muscle diagnosis and treatment system, the skin-like large-area self-feedback diagnosis and treatment system designed and prepared by the invention adopts a diagnosis and treatment integrated design, has small volume and high integration level, realizes different functions by connecting the skin-like surface muscle electrode array module with different modules, and solves the defect of complicated operation of the traditional system;
② Compared with the design of the traditional myoelectrodes and the electrical stimulation electrodes, the skin-like surface myoelectrode array module designed and prepared by the invention adopts the concentric ring configuration, so that the electrode array can realize the functions of myoelectric signal data acquisition, electrical stimulation treatment and the like in the use process, thereby realizing the purposes of diagnosis and treatment integration and optimizing the treatment effect; ③ The skin-like surface myoelectrode array module designed and prepared by the invention adopts the configuration of concentric circle electrodes, so that the electrode array can realize myoelectric signal differential acquisition of muscles in a certain part through a space differential circuit, and realize accurate electrical stimulation on a designated muscle part through a passage between each pair of electrode pairs, thereby achieving the purposes of improving the data quality and optimizing the treatment effect;
④ The whole structure of the skin-like surface myoelectrode array module designed and prepared by the invention adopts flexible materials with strong biocompatibility, is portable and wearable, can be repeatedly used, can comfortably and noninvasively measure myoelectric signals with high spatial resolution and high precision for a long time, and provides electric stimulation under the guidance of the myoelectric signal analysis result.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the description of the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some preferred embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a skin-like large-area self-feedback diagnostic system of the present invention.
Fig. 2 is a schematic structural view (a) and a detailed sectional view (b) of a skin-like surface myoelectrode array module according to an embodiment of the present invention.
Fig. 3 is a schematic structural diagram of an electromyographic signal acquisition module according to an embodiment of the invention.
Fig. 4 is a schematic structural diagram of an electrical stimulation pulse generating module according to an embodiment of the invention.
Fig. 5 is a flowchart of a diagnosis and treatment method according to an embodiment of the present invention.
In the figure: 10-skin-like surface myoelectrode array module 101-electrodes; 102-conducting wires; 103-a substrate; 104-an encapsulation layer; 105-lead interface; 20-an electromyographic signal acquisition module; 201 an analog-to-digital converter (ADC) module; 202-a preamplifier module; 203-a switcher module; 204-a suppression signal drift circuit module; 205-a digital signal processing module; 206-a wireless transmission module; 207-a data interface module; 208-a power management module; 209-a first micro control module; 30-an electrical stimulation pulse generation module; 301-a control unit module; 302-a pulse generation module; 303-an electrode channel conditioning module; 304-a power amplification module; 305-a constant voltage and constant current control module; 306-a safety shut-off device module; 307-microcontrol module two.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all, of the preferred embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the drawings, like structural elements are referred to by like reference numerals and components having similar structure or function are referred to by like reference numerals. The size, thickness and number of each component shown in the drawings are arbitrarily shown, and the present invention is not limited to the size, thickness and number of each component. The thickness of the components is exaggerated in some places in the drawings for clarity of illustration.
In the description of the present invention, it should be understood that the terms "left," "right," "symmetrical," "length," and the like indicate an orientation or positional relationship, and are merely for convenience in describing components in some preferred examples of the present invention, and do not indicate or imply that the components or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the invention.
Further description is provided below in connection with examples.
Fig. 1 shows a skin-like large-area self-feedback diagnosis and treatment system according to the present invention.
The skin-like large-area self-feedback diagnosis and treatment system comprises: the skin-like surface myoelectrode array module 10 is flexible and stretchable and is used for collecting electric signals and electrically stimulating muscle parts; the skin-like surface muscle electrode array module integrally adopts a sandwich structure, uses flexible materials with strong biocompatibility, adopts a concentric ring structure, and can perform multiple functions such as single-point acquisition, differential acquisition, electric stimulation treatment and the like so as to implement accurate measurement of muscle electric signals and accurate electric stimulation treatment in a long-term comfortable, noninvasive and large-area multipoint manner.
The myoelectric signal acquisition module 20 is integrated with an electronic circuit for acquiring the myoelectric signals, and is used for receiving the myoelectric signals acquired by the skin-like surface myoelectrode array module and performing data processing; the data processing comprises signal amplification, signal filtering, signal differential acquisition, data presentation, signal drift suppression and AD conversion.
The electric stimulation pulse generation module 30 is used for generating required electric stimulation pulses according to a stimulation scheme output by the computer, amplifying power and transmitting the electric stimulation pulses to the surface muscle electrode array module, and is used for carrying out electric stimulation treatment on muscles, and has the functions of constant voltage and constant current control, pulse frequency adjustment, pulse width adjustment, overcurrent protection and overvoltage protection.
Referring to fig. 2, a schematic structural view of a preferred embodiment of a skin-like surface muscle electrode array module 10 of the skin-like large-area self-feedback diagnostic system of the present invention is shown in fig. 2 (a) and a detailed sectional view of fig. 2 (b). The overall structure of the module mainly comprises 16 electrode pairs 101, wires 102, a substrate 103, a packaging layer 104 and a lead interface 105. The substrate 103 and the encapsulation layer 104 are made of biocompatible flexible materials, so that the device has good softness and extensibility and can adapt to complex irregular curved surface shapes, including human biological tissues and skin. In the use process, the conductive gel can be smeared on the surface of the electrode according to the requirement, so as to improve the good contact capability of the device and the skin.
The arrangement of the 16 electrode pairs 101 is as follows: the left side is provided with 2X4 = 8 electrode pairs 101 which are numbered from 1 to 16 from top to bottom and from left to right in an array manner; the right side array is provided with 2X4 = 8 electrode pairs 101 numbered 17 to 32 from top to bottom and from left to right. The lower lead interface 105 is numbered 1 to 32 in sequence from left to right, and the electrodes are correspondingly connected with the lead interfaces 105 by the leads 102 according to the numbers 1 to 32 respectively. The electrode pairs 101 are in a concentric ring configuration, the outer diameter of the outer ring electrode is 2.7mm, the inner diameter of the outer ring electrode is 2.0mm, the outer diameter of the inner ring electrode is 1.3mm, the inner diameter of the inner ring electrode is 0.6mm, the spacing between the adjacent electrode pairs 101 in the same row is 10mm, and the spacing between the adjacent electrode pairs 101 in the same row is 10mm.
The electrode array is configured as a sandwich, and is sequentially provided with a packaging layer 104 from bottom to top, a substrate 103 printed with an electrode pair 101, a wire 102 and a lead interface 105, and the packaging layer 104. The uppermost encapsulation layer 104 is left with a preformed hole, and the preformed hole diameter is slightly smaller than the size of the electrode pair 101.
The flexible stretchable substrate 103 is made of stretchable polyurethane (TPU) or Polydimethylsiloxane (PDMS) with a thickness of 10 microns or 25 microns or 50 microns.
The flexible stretchable packaging layer 104 is made of acrylic double faced adhesive tape or medical grade silica gel double faced adhesive tape, and the thickness of the flexible stretchable packaging layer is 10 microns, 25 microns or 50 microns.
The materials of the electrode pair 101, the interconnection wire 102 and the lead interface 105 are stretchable conductive silver paste or graphene, and the thickness is 10nm.
A circular arrangement of ventilation holes is provided near each electrode on the substrate 103.
Fig. 3 is a schematic structural diagram of a preferred embodiment of the myoelectric signal acquisition module 20 of the skin-like large-area self-feedback diagnosis and treatment system according to the present invention. The myoelectric signal acquisition module comprises: an analog-to-digital converter (ADC) module 201 for receiving the electrical signal of the skin-like surface myoelectrode array module and converting the analog signal into a digital signal; a pre-amplifier module 202 for receiving the signal of the analog-to-digital converter (ADC) module 201 and performing preliminary amplification; the switcher module 203 is used for realizing switching between a single-point acquisition mode and a differential acquisition mode so as to adapt to different acquisition requirements; a signal drift suppression circuit module 204, configured to receive the data processed by the pre-amplifier module 202, and suppress a signal drift phenomenon through differential amplification and filtering techniques; the digital signal processing module 205 is configured to receive the data of the signal drift suppression circuit module 204, and perform filtering, noise reduction and feature extraction; the wireless transmission module 206 is configured to receive the data processed by the digital signal processing module 205, and implement wireless data transmission through bluetooth, wi-Fi or other wireless protocols; a data interface module 207, configured to receive the data processed by the digital signal processing module 205, and transmit the data to a computer through a wired transmission interface (such as USB); the power management module 208 ensures stable power supply of other modules and reduces power consumption as much as possible; and the micro control module I209 is used for controlling the electromyographic signal acquisition module to work normally.
Fig. 4 is a schematic structural diagram of an electrical stimulation pulse generating module 30 of the skin-like large-area self-feedback diagnosis and treatment system according to a preferred embodiment of the present invention. The electrical stimulation pulse generation module comprises: the control unit module 301 is responsible for controlling and coordinating the whole module, and receives a stimulation scheme input by a computer to adjust the electrical stimulation parameters; the pulse generation module 302 generates an electric stimulation pulse signal with adjustable frequency and width according to the electric stimulation parameters, and adjusts the current intensity to adapt to the muscle treatment requirements of different parts and different damage degrees; the electrode channel adjusting module 303 selects an electrode channel which is conducted according to the electric stimulation parameters so as to directionally stimulate muscles of different parts; the power amplification module 304 is used for amplifying the power of the electric stimulation pulse signals generated by the pulse generation module so as to meet the stimulation requirement of the muscle tissues of the patient; the constant voltage and constant current control module 305 keeps the voltage or current of the electric stimulation pulse signal output by the power amplification module 304 constant, and ensures the stability of treatment; the safety cut-off device module 306 automatically cuts off the output of the electric stimulation pulse signal of the power amplification module 304 when an abnormal situation occurs, so as to ensure the safety of a patient; and the micro control module II 307 controls the electric stimulation pulse generation module 30 to work normally.
Fig. 5 shows a diagnosis and treatment method applicable to the skin large-area self-feedback diagnosis and treatment system, which comprises the following steps:
1) Early preparation: cleaning the surface of human skin with sterilizing alcohol and scrub, filling commercial solid conductive paste (Ten 20, wever, usa) in the exposed part of the skin-like patch muscle electrode and pasting the surface towards the skin, and compacting the device to achieve conformal adhesion with the skin;
2) And (3) signal acquisition: the skin-like surface myoelectrode array module in the system is connected with the myoelectric signal acquisition module, the myoelectric signals generated by muscle parts of patients are acquired and subjected to preliminary processing, and the myoelectric signals are transmitted to a computer for further processing and analysis through the wireless transmission module or the data interface module in the myoelectric signal acquisition module.
3) Signal processing and diagnosis: the acquired muscle electrical signals are utilized to generate a dynamic RMS cloud image so as to realize the visualization of data, visually embody the activity condition of muscles, extract characteristics such as kurtosis, lempel-Ziv complexity, power spectrum peak frequency, power spectrum total power, power spectrum average frequency and the like of the data, utilize a linear discriminant analysis (LINEAR DISCRIMINANT ANALYSIS) algorithm to perform dimension reduction, establish a random forest algorithm (Random Forest Algorithm) model, deliver the dimension-reduced data to the model and acquire diagnosis results of damaged parts and damaged degrees of muscles of patients.
4) Electrical stimulation treatment: the muscle position stimulated during the electric stimulation treatment and the electric stimulation current intensity are determined according to the diagnosis result, a skin-like surface muscle electrode array module in the system is connected with an electric stimulation pulse generation module, and the intensity of the electric stimulation pulse generated by the electric stimulation pulse generation module and the number of conducted channels are set, so that the accurate electric stimulation treatment is realized.
The skin-like large-area self-feedback diagnosis and treatment system designed and prepared by the invention integrates different circuit modules and has the function of diagnosis and treatment integration. The skin-like surface muscle electrode array module designed and prepared by the invention adopts the electrode configuration of concentric circular rings, thereby realizing the realization of multiple functions; all materials are flexible materials with good biocompatibility, and the structure is stretchable. The skin large-area self-feedback diagnosis and treatment system is portable, wearable and reusable, can measure high-spatial resolution and high-precision myoelectric signals comfortably and noninvasively for a long time, and provides electric stimulation under the guidance of the analysis result of the myoelectric signals. The method has important application value in the fields of future electromyographic signal acquisition, electric stimulation treatment, real-time online monitoring, real-time human-computer interaction, mobile medical equipment, internet of things and the like.
Claims (6)
1. A skin-like large-area self-feedback diagnostic system, comprising:
the skin-like surface muscle electrode array module is flexible and stretchable and is used for collecting electric signals and electrically stimulating and treating muscles; the skin-like surface muscle electrode array module is integrally in a sandwich configuration, a flexible material with high biocompatibility is used, and the electrodes are in a concentric ring configuration;
the myoelectric signal acquisition module is integrated with an electronic circuit for acquiring the myoelectric signals and is used for receiving the myoelectric signals acquired by the skin-like surface myoelectrode array module and performing data processing; the data processing comprises signal amplification, signal filtering, signal differential acquisition, data presentation, signal drift suppression and AD conversion; the electromyographic signal acquisition module transmits the processed data to a computer, and the computer analyzes the data and outputs a stimulation scheme;
and the electric stimulation pulse generation module is used for generating required electric stimulation pulses according to a stimulation scheme output by the computer, amplifying power and transmitting the electric stimulation pulses to the skin-like surface muscle electrode array module so as to perform electric stimulation treatment on muscles.
2. The skin-like large area self-feedback diagnostic system of claim 1, wherein the skin-like surface myoelectrode array module comprises N pairs of electrodes, wires, a substrate, a packaging layer, a lead interface; the substrate is an intermediate layer, the electrode pairs and the lead interfaces are positioned on the substrate, each lead interface comprises 2N lead ends, each electrode is connected to one lead end of the lead interface through a lead, the packaging layer is arranged on the bottom layer and the top layer of the substrate, and only each electrode pair and the lead interfaces are exposed;
each pair of electrodes has 2 electrodes, and the structure adopts a concentric ring configuration and is connected out by independent wires;
And the lead interface is connected with an electromyographic signal acquisition module and an electrical stimulation pulse generation module in the system through the patch cord.
3. The skin-like large area self-feedback diagnostic system as claimed in claim 2, wherein the substrate is provided with a circular arrangement of ventilation holes near each electrode.
4. The skin-like large area self-feedback diagnostic system of claim 1, wherein the skin-like surface myoelectrode array module is prepared by using a ductile flexible electronic technique.
5. The skin-like large-area self-feedback diagnosis and treatment system according to claim 1, wherein the electromyographic signal acquisition module comprises:
an analog-to-digital converter (ADC) module for receiving the electrical signal of the skin-like surface myoelectrode array module and converting the analog signal into a digital signal;
A pre-amplifier module for receiving the signal of the analog-to-digital converter (ADC) module and performing preliminary amplification;
The switcher module is used for realizing switching between a single-point acquisition mode and a differential acquisition mode so as to adapt to different acquisition requirements;
The signal drift suppression circuit module is used for receiving the data processed by the pre-amplifier module and suppressing the signal drift phenomenon through differential amplification and filtering technology;
the digital signal processing module is used for receiving the data of the signal drift suppression circuit module and carrying out filtering, noise reduction and feature extraction;
the wireless module is used for receiving the data processed by the digital signal processing module and realizing wireless data transmission through a wireless protocol;
the data interface module is used for receiving the data processed by the digital signal processing module and transmitting the data to the computer through the wired transmission interface;
The power management module ensures stable power supply of other modules;
And the micro control module is used for controlling the electromyographic signal acquisition module to work normally.
6. The skin-like large area self-feedback diagnostic system according to claim 1, wherein said electrical stimulation pulse generation module comprises:
the control unit module is responsible for controlling and coordinating the whole module and receiving a stimulation scheme input by a computer so as to adjust the electric stimulation parameters;
The pulse generation module is used for generating an electric stimulation pulse signal with adjustable frequency and width according to the electric stimulation parameters and adjusting current intensity so as to adapt to muscle treatment requirements of different parts and different damage degrees:
the electrode channel adjusting module selects an electrode channel which is conducted according to the electric stimulation parameters so as to directionally stimulate muscles at different positions;
the power amplification module is used for amplifying the power of the electric stimulation pulse signals generated by the pulse generation module so as to meet the stimulation requirement of muscle tissues of a patient;
The constant voltage and constant current control module is used for keeping the voltage or current of the electric stimulation pulse signal output by the power amplification module constant and ensuring the stability of treatment;
the safety cut-off device module automatically cuts off the electric stimulation pulse signal output of the power amplification module when abnormal conditions occur, so that the safety of a patient is ensured;
and the micro control module is used for controlling the electric stimulation pulse generation module to work normally.
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| CN202410260785.XA CN118022174A (en) | 2024-03-07 | 2024-03-07 | Skin-like large-area self-feedback diagnosis and treatment system |
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| CN202410260785.XA CN118022174A (en) | 2024-03-07 | 2024-03-07 | Skin-like large-area self-feedback diagnosis and treatment system |
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