CN118021420B - Pulse electrothermal composite field ablation treatment system - Google Patents
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Abstract
The invention is suitable for the field of medical appliances, and provides a pulse electrothermal composite field ablation treatment system. In this embodiment, the pulse electrothermal composite physical field cooperative control module has a plurality of ablation treatment strategy cooperative control functions, adaptively adjusts and controls the pulse electric field ablation device and the thermal field ablation device according to the corresponding ablation treatment strategies according to the dynamic changes of the thermal field ablation region and the pulse electric field ablation region in the ablation treatment process, and determines whether to adjust or end the ablation treatment according to the treatment time and the instant ablation region determined by the thermal field ablation range calculation module and the pulse electric field ablation range calculation module. The method realizes the synergy and effectiveness of the combined use of the pulse electric ablation technology and the thermal field ablation technology, and improves the safety and the accuracy of treatment by complementing the advantages of the double-field combined ablation treatment.
Description
Technical Field
The application relates to the field of medical appliances, in particular to a pulse electrothermal composite field ablation treatment system.
Background
The principle of pulse electric field ablation is that high-voltage electric pulse is applied to tumor cell membrane to form irreversible nanometer pore canal and induce apoptosis of tumor cell, so that the fibrous skeleton of blood vessel, pancreas bile duct, nerve, etc. may be protected. The advantage of selectively inactivating tumors without damaging adjacent important tissues is that the pulsed electric field ablation is widely focused once occurring, and the pulsed electric field ablation has wide application prospect in the treatment of multiple tumors such as liver cancer, pancreatic cancer, kidney cancer, prostate cancer and the like.
Although pulsed electric field ablation has the characteristic of selective tissue damage which thermal field ablation does not have, the use condition of pulsed electric field ablation technology is complex than thermal field ablation, and the use cost performance of thermal field ablation technology is higher for part of common lesions which have low requirement on tissue selectivity or have heat sink effect due to non-adjacent large blood vessels. In addition, there may be residual ablation needle of focus living cells during pulsed electric field ablation, and implantation risk of cancer cell diffusion is caused in needle tract area during needle withdrawal; in addition, the risk of bleeding during needle withdrawal cannot be completely ignored. The thermal field ablation can just make up for the defect of the pulsed electric field ablation, and the advantages of the thermal field ablation and the pulsed electric field ablation can be complemented by combining the thermal field ablation and the pulsed electric field ablation, but no proper method for effectively combining the thermal field ablation and the pulsed electric field ablation in a synergistic manner in time and space exists at present.
Disclosure of Invention
In view of the above, the application provides a pulse electric heating composite field ablation treatment system to improve the synergy and effectiveness of the combined use of the pulse electric ablation and thermal field ablation technologies, thereby improving the safety and accuracy of treatment.
A first aspect of the present application provides a pulsed electrothermal composite field ablation treatment system, the system comprising:
The system comprises a pulse electric heating composite physical field cooperative control module, a pulse electric field ablation range calculation module, a thermal field ablation range calculation module, an image processing and analysis module and a treatment ROI region sketching module;
The treatment ROI region sketching module is used for dividing the region to be treated into a thermal field ablation region to be treated and a pulse electric field ablation region to be treated according to the medical image of the region to be treated;
The pulse electric heating composite physical field cooperative control module has a plurality of cooperative control functions of ablation treatment strategies, and is used for automatically adjusting the region to be treated according to dynamic changes of an instant ablation region and a preset ablation treatment strategy in the ablation treatment process, and carrying out composite field ablation treatment cooperation on pulse electric field ablation equipment and thermal field ablation equipment so as to realize an ablation target, wherein the instant ablation region comprises the instant pulse electric field ablation region and the instant thermal field ablation region, and the ablation target is a preset ablation region which is determined by a comparison result sent by the pulse electric field ablation range calculation module, the thermal field ablation range calculation module and the image processing and analysis module;
the pulse electric field ablation range calculation module is used for calculating an immediate pulse electric field ablation area;
the thermal field ablation range calculation module is used for calculating an instant thermal field ablation region;
The image processing and analyzing module is used for acquiring the instant ablation area determined by the pulse electric field ablation range calculating module and the thermal field ablation range calculating module, comparing and analyzing the instant ablation area with a preset ablation treatment area, and transmitting a comparison result to the pulse electric heating composite physical field cooperative control module.
Optionally, the ablation treatment strategy cooperative control function in the pulse electrothermal composite physical field cooperative control module includes:
The pulse electric field ablation treatment of the overlapping area is prioritized, the thermal field ablation treatment of the overlapping area is prioritized, the overlapping area is not prioritized and is not repeatedly ablated, and the overlapping area is not prioritized and is repeatedly ablated.
Optionally, the implementation mode of the overlapping area pulse electric field ablation treatment priority is as follows:
the method comprises the steps of taking a thermal field ablation zone to be treated and a pulse electric field ablation zone to be treated determined by a treatment ROI zone sketching module as initial regulation and control targets, and determining an overlapping area of the thermal field ablation zone to be treated and the pulse electric field ablation zone to be treated;
Acquiring a pulse electric field instant ablation region and a thermal field instant ablation region from a pulse electric field ablation range calculation module and a thermal field ablation range calculation module;
Determining whether a part of the overlapping area is ablated by the pulse electric field according to the pulse electric field instant ablation area, if so, removing the part of the overlapping area from the pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area, and dynamically adjusting the pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area so that the adjusted pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area are updated regulation targets;
pulse electric field ablation and thermal field ablation are continued until the thermal field ablates the region to be treated and the pulse electric field ablates the region to be treated to be completely ablated.
Optionally, the implementation mode of the overlapping region thermal field ablation treatment priority is as follows:
the method comprises the steps of taking a thermal field ablation zone to be treated and a pulse electric field ablation zone to be treated determined by a treatment ROI zone sketching module as initial regulation and control targets, and determining an overlapping area of the thermal field ablation zone to be treated and the pulse electric field ablation zone to be treated;
Acquiring a pulse electric field instant ablation region and a thermal field instant ablation region from a pulse electric field ablation range calculation module and a thermal field ablation range calculation module;
Determining whether a partial area of the overlapped area is ablated by a thermal field according to the thermal field instant ablation area, if so, removing the partial area from a pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area, and dynamically adjusting the pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area so that the adjusted pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area are updated regulation targets;
pulse electric field ablation and thermal field ablation are continued until the thermal field ablates the region to be treated and the pulse electric field ablates the region to be treated to be completely ablated.
Optionally, the implementation manner that the overlapping area is not set with priority and ablation is not repeated is as follows:
the method comprises the steps of taking a thermal field ablation zone to be treated and a pulse electric field ablation zone to be treated determined by a treatment ROI zone sketching module as initial regulation and control targets, and determining an overlapping area of the thermal field ablation zone to be treated and the pulse electric field ablation zone to be treated;
Acquiring a pulse electric field instant ablation region and a thermal field instant ablation region from a pulse electric field ablation range calculation module and a thermal field ablation range calculation module;
Determining whether a part of the overlapping area is ablated by the pulse electric field according to the pulse electric field instant ablation area, if so, removing the part of the overlapping area from the pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area, and dynamically adjusting the pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area so that the adjusted pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area are updated regulation targets; or alternatively, the first and second heat exchangers may be,
Determining whether a partial area of the overlapped area is ablated by a thermal field according to the thermal field instant ablation area, if so, removing the partial area from a pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area, and dynamically adjusting the pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area so that the adjusted pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area are updated regulation targets;
pulse electric field ablation and thermal field ablation are continued until the thermal field ablates the region to be treated and the pulse electric field ablates the region to be treated to be completely ablated.
Optionally, the implementation manner that the overlapping area is not set with priority and can be repeatedly ablated is as follows:
the method comprises the steps of taking a thermal field ablation zone to be treated and a pulse electric field ablation zone to be treated determined by a treatment ROI zone sketching module as initial regulation and control targets, and determining an overlapping area of the thermal field ablation zone to be treated and the pulse electric field ablation zone to be treated;
Acquiring a pulse electric field instant ablation region and a thermal field instant ablation region from a pulse electric field ablation range calculation module and a thermal field ablation range calculation module;
when the partial area of the overlapping area is determined to be ablated by the pulse electric field according to the pulse electric field immediate ablation area, the partial area is removed from the pulse electric field ablation to-be-treated area, and the pulse electric field ablation to-be-treated area is dynamically adjusted;
When the fact that the partial area of the overlapped area is ablated by the thermal field is determined according to the thermal field instant ablation area, the partial area is removed from the thermal field ablation to-be-treated area, and the thermal field ablation to-be-treated area is dynamically adjusted;
And taking the adjusted pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area as updated regulation targets, and continuously performing pulse electric field ablation and thermal field ablation until the thermal field ablation to-be-treated area and the pulse electric field ablation to-be-treated area are completely ablated.
Optionally, the thermal field ablation range calculation module further includes a temperature acquisition module;
The temperature acquisition module is connected with the ablation needle and used for acquiring temperature information of the ablation needle in real time.
Optionally, the pulsed electric field ablation range calculation module further includes a pulsed electric field ablation treatment information acquisition module;
The pulse electric field ablation treatment information acquisition module is connected with the pulse electric field ablation treatment equipment and is used for acquiring pulse electric field ablation treatment information in real time.
In the embodiment provided by the application, the pulse electric heating composite physical field cooperative control module has a plurality of ablation treatment strategy cooperative control functions, and the ablation areas are adaptively adjusted according to the corresponding ablation treatment strategies according to the dynamic changes of the thermal field ablation areas and the pulse electric field ablation areas in the ablation treatment process, the composite field ablation treatment cooperation is carried out on the pulse electric field ablation equipment and the thermal field ablation equipment, and whether the current ablation treatment is adjusted or ended is determined according to the treatment time, the thermal field ablation range calculation module and the instant ablation areas determined by the pulse electric field ablation range calculation module.
The method realizes the synergy and effectiveness of the combined use of the pulse electric ablation technology and the thermal field ablation technology, and improves the safety and the accuracy of treatment by complementing the advantages of the double-field combined ablation treatment.
Drawings
FIG. 1 is a system block diagram provided by an embodiment of the present application;
FIG. 2 is a spatial view of an ablation zone provided by an embodiment of the present application;
FIG. 3 is a timing diagram of pulsed electric field ablation and thermal field ablation provided by an embodiment of the present application;
Fig. 4 is a flowchart of a method according to an embodiment of the present application.
Detailed Description
Reference will now be made in detail to exemplary embodiments, examples of which are illustrated in the accompanying drawings. When the following description refers to the accompanying drawings, the same numbers in different drawings refer to the same or similar elements, unless otherwise indicated. The implementations described in the following exemplary examples do not represent all implementations consistent with the application. Rather, they are merely examples of apparatus and methods consistent with aspects of the application as detailed in the accompanying claims.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in this specification and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It should also be understood that the term "and/or" as used herein refers to and encompasses any or all possible combinations of one or more of the associated listed items.
It should be understood that although the terms first, second, third, etc. may be used herein to describe various information, these information should not be limited by these terms. These terms are only used to distinguish one type of information from another. For example, first information may also be referred to as second information, and similarly, second information may also be referred to as first information, without departing from the scope of the application. The word "if" as used herein may be interpreted as "at … …" or "at … …" or "in response to a determination" depending on the context.
The technical scheme of the application is described in detail below by specific examples. The following embodiments may be combined with each other, and some embodiments may not be repeated for the same or similar concepts or processes.
As shown in fig. 1, a system block diagram of a pulse electrothermal composite field ablation treatment system according to the present application is provided, the system comprising: the system comprises a pulse electric heating composite physical field cooperative control module, a pulse electric field ablation range calculation module, a thermal field ablation range calculation module, an image processing and analysis module and a treatment ROI region sketching module.
The treatment ROI region sketching module is used for dividing the region to be treated into a thermal field ablation region and a pulse electric field ablation region according to the medical image of the region to be treated.
In the module, the medical image of the region to be treated can be acquired by medical imaging equipment such as ultrasonic imaging, CT imaging, MR imaging and the like. Before treatment begins, medical staff delineates sensitive areas and non-sensitive areas by medical images of the area to be treated. In general, the sensitive area contains important blood vessels, nerves or other tissue structures which need to be protected from ablation, and selective ablation treatment is needed by using a pulsed electric field ablation technology, so that the sensitive area is determined as a region to be treated by pulsed electric field ablation. The non-sensitive area does not need a tissue structure which is selectively protected, and can be treated by thermal field ablation, and the thermal field is determined to ablate the area to be treated.
The pulse electric heating composite physical field cooperative control module has a plurality of cooperative control functions of an ablation treatment strategy, and is used for automatically adjusting the region to be treated according to the dynamic change of an immediate ablation region and a preset ablation treatment strategy in the ablation treatment process, and carrying out composite field ablation treatment cooperation on pulse electric field ablation equipment and thermal field ablation equipment so as to realize an ablation target, wherein the immediate ablation region comprises an immediate pulse electric field ablation region and an immediate thermal field ablation region, and the ablation target is an immediate ablation region which reaches the preset ablation region through a comparison result sent by the pulse electric field ablation range calculation module, the thermal field ablation range calculation module and the image processing and analysis module;
Alternatively, the system may also set the time of the current ablation treatment to reach a preset ablation time as the ablation target.
For example, the image processing and analysis module may obtain a preset ablation zone in advance when determined by the comparison resultWhen ablation treatment is carried out, an immediate ablation area is determined in real time according to the current ablation treatmentBy comparing this, the image data obtained by the image analysis,And determining whether to end the ablation treatment or not through the ablation region.
When the ablation time is determined, the pulse electrothermal composite physical field cooperative control module can preset the ablation timeAnd time counting is performed at the beginning of the ablation treatment to determine the time of the ablation treatmentBy comparing this, the image data obtained by the image analysis,And determining whether to end the ablation treatment or not according to the ablation time.
The ablation treatment strategy cooperative control function in the pulse electrothermal composite physical field cooperative control module comprises the following steps: the pulse electric field ablation treatment of the overlapping area is prioritized, the thermal field ablation treatment of the overlapping area is prioritized, the overlapping area is not prioritized and is not repeatedly ablated, and the overlapping area is not prioritized and is repeatedly ablated.
Fig. 2 is a spatial illustration of an ablation zone:
1. Overlapping area pulse electric field ablation treatment priority strategy cooperative control function
The implementation mode is as follows: and respectively taking the thermal field ablation region to be treated and the pulsed electric field ablation region to be treated as regulation targets, and determining the overlapping region of the thermal field ablation region to be treated and the pulsed electric field ablation region to be treated.
The pulsed electric field instant ablation region and the thermal field instant ablation region are respectively obtained from the pulsed electric field ablation range calculation module and the thermal field ablation range calculation module,
For the overlapping area, whether the partial area of the overlapping area is ablated by the thermal field or not, the pulse electric field ablates the area to be treated without adjustment; if part of the overlapped area is ablated by the pulsed electric field, removing the area from the thermal field ablation zone to be treated, dynamically adjusting the thermal field ablation zone to be treated, and taking the adjusted thermal field ablation zone to be treated as a new regulation target; the pulse electric field ablation and the thermal field ablation are respectively carried out continuously until the respective ablation areas to be treated are completely ablated;
2. Overlapping region thermal field ablation treatment priority strategy cooperative control function
The implementation mode is as follows: and respectively taking the thermal field ablation region to be treated and the pulsed electric field ablation region to be treated as regulation targets, and determining the overlapping region of the thermal field ablation region to be treated and the pulsed electric field ablation region to be treated.
And respectively acquiring a pulse electric field instant ablation region and a thermal field instant ablation region from the pulse electric field ablation range calculation module and the thermal field ablation range calculation module.
For the overlapping region, whether partial regions of the overlapping region are ablated by the pulsed electric field or not, the thermal field ablates the region to be treated without adjustment; if part of the overlapping area is ablated by the thermal field, removing the part of the overlapping area in the pulse electric field ablation zone to be treated, dynamically adjusting the pulse electric field ablation zone to be treated, and taking the adjusted pulse electric field ablation zone to be treated as a new regulation target; pulsed electric field ablation and thermal field ablation are each continued until the respective ablation treatment zone is completely ablated.
3. Overlapping area no priority setting and no repetition of ablation strategy cooperative control function
The implementation mode is as follows: and respectively taking the thermal field ablation region to be treated and the pulsed electric field ablation region to be treated as regulation targets, and determining the overlapping region of the thermal field ablation region to be treated and the pulsed electric field ablation region to be treated.
And respectively acquiring a pulse electric field instant ablation region and a thermal field instant ablation region from the pulse electric field ablation range calculation module and the thermal field ablation range calculation module.
For the overlapping region, if a part of the overlapping region is ablated by the thermal field, removing the part of the overlapping region from the pulse electric field ablation region to be treated, dynamically adjusting the pulse electric field ablation region to be treated, and taking the adjusted pulse electric field ablation region to be treated as a new regulation target; likewise, if a partial area of the overlapping area is ablated by the pulsed electric field, removing the partial area from the thermal field ablation treatment area, dynamically adjusting the thermal field ablation treatment area, and taking the adjusted thermal field ablation treatment area as a new regulation target; the pulse electric field ablation and the thermal field ablation are respectively carried out continuously until the respective ROI target areas are completely ablated;
4. Overlapping area no priority setting and repeatable ablation strategy cooperative control function
The implementation mode is as follows: and respectively taking the thermal field ablation region to be treated and the pulsed electric field ablation region to be treated as regulation targets, and determining the overlapping region of the thermal field ablation region to be treated and the pulsed electric field ablation region to be treated.
And respectively acquiring a pulse electric field instant ablation region and a thermal field instant ablation region from the pulse electric field ablation range calculation module and the thermal field ablation range calculation module.
For the above overlapping area, no matter whether the partial area of the overlapping area is ablated by the pulsed electric field or the thermal field, the thermal field ablates the area to be treated or the pulsed electric field ablates the area to be treated is not adjusted; pulsed electric field ablation and thermal field ablation, respectively, are continued until the respective ROI target region is completely ablated.
The above details the cooperative control of the ablation treatment strategy in the overlap region. In the module, different strategies can be set for the non-overlapping area to cooperatively control according to different application scenes.
Exemplary, scenario 1: the thermal field ablation assists the pulse electric field ablation to perform thermal coagulation, bleeding prevention and tumor cell implantation prevention. The pulsed electric field ablation treatment area under the scene comprises a thermal field ablation treatment area, the pulsed electric field ablation treatment is started first, and the thermal field ablation treatment is started after the pulsed electric field ablation treatment is finished. The pulsed electric field and the thermal field in this scenario sequentially ablate the same specific tissue region, with sequential timing, as shown in fig. 3.
Scene 2: the clinical application scene of time sequence does not need to be considered for ablation, and the two fields are simultaneously opened so as to exert the respective advantages of pulse electric field ablation and thermal field ablation and improve the ablation treatment efficiency.
Scene 3: the pulse electric field ablation area and the thermal field ablation area have no space interaction and no time sequence interaction, and at the moment, the pulse electric field and the thermal field can be simultaneously opened to perform ablation treatment on different tissue areas, and the ablation treatment is performed after the treatment is started until an ablation target is reached.
In particular, any one, two, or three of the above-described scenarios may be combined, which is not limited by the present application. Through the ablation treatment strategy, the application is not only suitable for the scene of the pulse electric-thermal field ablation integrated equipment, but also suitable for the scene of the split and combined use of the pulse electric ablation equipment and the thermal field ablation equipment.
The pulsed electric field ablation range calculation module is used for calculating an immediate pulsed electric field ablation region according to the pulsed electric field ablation treatment information.
The module can also comprise a pulse electric field ablation treatment information acquisition module;
The pulse electric field ablation treatment information acquisition module is connected with the pulse electric field ablation treatment equipment and is used for acquiring pulse electric field ablation treatment information in real time.
The thermal field ablation range calculation module is used for calculating an immediate thermal field ablation region according to parameters of the ablation needle.
The module can also comprise a temperature acquisition module; the temperature acquisition module is connected with the ablation needle and used for acquiring temperature information of the ablation needle in real time.
The image processing and analyzing module is used for acquiring the instant ablation area determined by the pulse electric field ablation range calculating module and the thermal field ablation range calculating module, comparing and analyzing the instant ablation area with a preset ablation treatment area, and transmitting a comparison result to the pulse electric heating composite physical field cooperative control module.
The pulse electrothermal composite field ablation treatment system can further comprise a magnetic positioning acquisition module, a display module and a magnetic positioning sensor, wherein the magnetic positioning acquisition module is connected with the magnetic positioning sensor on the ablation needle, and the spatial position information of the ablation needle is acquired in real time. The display module is used for displaying the progress of the pulsed electric-thermal composite physical field ablation treatment in real time.
Thus, the system module description shown in fig. 1 is completed.
In the application, the pulse electrothermal composite physical field cooperative control module has a plurality of cooperative control functions of ablation treatment strategies, and performs self-adaptive regulation and control according to the corresponding ablation treatment strategies according to the dynamic changes of the thermal field ablation zone and the pulse electric field ablation zone in the ablation treatment process, so as to perform composite field ablation treatment cooperation on the pulse electric field ablation equipment and the thermal field ablation equipment. The method realizes the synergy and effectiveness of the combined use of the pulse electric ablation technology and the thermal field ablation technology, and improves the safety and the accuracy of treatment by complementing the advantages of the double-field combined ablation treatment. And through different ablation treatment strategies, the application is not only suitable for the scene of pulse electric-thermal field ablation integrated equipment, but also suitable for the scene of split combined use of pulse electric ablation equipment and thermal field ablation equipment.
The following description is made by way of a specific embodiment, and as shown in fig. 4, is a flowchart of a method of a pulse electrothermal composite field ablation treatment system when a pulse electric field and a thermal field sequentially perform combined ablation treatment on the same specific tissue region:
step 1, treatment preparation. In the step, medical personnel delineate a thermal field ablation zone and a pulse electric field ablation zone through a treatment ROI zone delineating module.
And 2, starting pulsed electric field ablation treatment. In the step, after the pulse electrothermal composite physical field cooperative control module determines an ablation treatment strategy, the pulse electric field ablation equipment is controlled to perform pulse electric field ablation treatment.
And 3, collecting pulse electric field ablation treatment information and the position of an ablation needle. The method comprises the steps of collecting position information of an ablation needle in real time through a magnetic positioning collecting module, and collecting pulse electric field ablation treatment information in real time through a pulse electric field ablation range calculating module.
And 4, calculating a pulse electric field ablation range, wherein the step is realized by a pulse electric field ablation range calculation module.
And 5, determining whether the pulse electric field ablation target is reached, acquiring an instant pulse electric field ablation zone determined by the pulse electric field ablation range calculation module by the pulse electric heating composite physical field cooperative control module, comparing the instant pulse electric field ablation zone with the sketched pulse electric field ablation zone, determining whether the pulse electric field ablation target is reached, and jumping to the step 2 to start pulse electric field ablation treatment when the pulse electric field ablation target is not reached. When the criterion is reached, the process goes to step 6.
And 6, starting thermal field ablation treatment. In the step, a pulse electrothermal composite physical field cooperative control module controls a thermal field ablation device to perform thermal field ablation treatment.
And 7, acquiring temperature information and the position of the ablation needle. The method comprises the steps of collecting position information of an ablation needle in real time through a magnetic positioning collecting module, and collecting temperature information in real time through a thermal field ablation range calculating module.
And 8, calculating a pulse electric field ablation range, wherein the step is realized by a thermal field ablation range calculation module.
And 9, determining whether the thermal field ablation target is reached, acquiring an instant thermal field ablation zone determined by the thermal field ablation range calculation module by the pulse electrothermal composite physical field cooperative control module, comparing the instant thermal field ablation zone with the sketched thermal field ablation zone, determining whether the thermal field ablation target is reached, and jumping to the step 6 to start thermal field ablation treatment when the thermal field ablation target is not reached. And when the standard is reached, ending the ablation treatment.
In the flow, the overlapping area is subjected to combined ablation treatment through the pulse electric field and the thermal field, so that the safety and the accuracy of treatment are improved.
The foregoing description of the preferred embodiments of the application is not intended to be limiting, but rather to enable any modification, equivalent replacement, improvement or the like to be made within the spirit and principles of the application.
Claims (7)
1. A pulsed electrothermal composite field ablation treatment system, the system comprising:
The system comprises a pulse electric heating composite physical field cooperative control module, a pulse electric field ablation range calculation module, a thermal field ablation range calculation module, an image processing and analysis module and a treatment ROI region sketching module;
The treatment ROI region sketching module is used for dividing the region to be treated into a thermal field ablation region to be treated and a pulse electric field ablation region to be treated according to the medical image of the region to be treated;
The pulse electric heating composite physical field cooperative control module has a plurality of cooperative control functions of ablation treatment strategies, and is used for automatically adjusting the region to be treated according to dynamic changes of an instant ablation region and a preset ablation treatment strategy in the ablation treatment process, and carrying out composite field ablation treatment cooperation on pulse electric field ablation equipment and thermal field ablation equipment so as to realize an ablation target, wherein the instant ablation region comprises the instant pulse electric field ablation region and the instant thermal field ablation region, and the ablation target is a preset ablation region which is determined by a comparison result sent by the pulse electric field ablation range calculation module, the thermal field ablation range calculation module and the image processing and analysis module;
The ablation treatment strategy cooperative control function comprises overlapping area pulse electric field ablation treatment priority, wherein the overlapping area is determined by taking a thermal field ablation to-be-treated area and a pulse electric field ablation to-be-treated area determined by a treatment ROI (region of interest) sketching module as initial regulation targets and determining the thermal field ablation to-be-treated area and the pulse electric field ablation to-be-treated area; the realization method comprises the following steps:
Acquiring a pulse electric field instant ablation region and a thermal field instant ablation region from a pulse electric field ablation range calculation module and a thermal field ablation range calculation module;
Determining whether a part of the overlapping area is ablated by the pulse electric field according to the pulse electric field instant ablation area, if so, removing the part of the overlapping area from the pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area, and dynamically adjusting the pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area so that the adjusted pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area are updated regulation targets;
Continuously performing pulse electric field ablation and thermal field ablation until the thermal field ablation region to be treated and the pulse electric field ablation region to be treated are completely ablated;
the pulse electric field ablation range calculation module is used for calculating an immediate pulse electric field ablation area;
the thermal field ablation range calculation module is used for calculating an instant thermal field ablation region;
The image processing and analyzing module is used for acquiring the instant ablation area determined by the pulse electric field ablation range calculating module and the thermal field ablation range calculating module, comparing and analyzing the instant ablation area with a preset ablation treatment area, and transmitting a comparison result to the pulse electric heating composite physical field cooperative control module.
2. The system of claim 1, wherein the ablation therapy strategy cooperative control function in the pulse electrothermal composite physical field cooperative control module further comprises:
The thermal field ablation treatment of the overlapping area is prioritized, the overlapping area is not prioritized and the ablation is not repeated, and the overlapping area is not prioritized and the ablation can be repeated.
3. The system of claim 2, the overlapping region thermal field ablation therapy is preferably implemented by:
the method comprises the steps of taking a thermal field ablation zone to be treated and a pulse electric field ablation zone to be treated determined by a treatment ROI zone sketching module as initial regulation and control targets, and determining an overlapping area of the thermal field ablation zone to be treated and the pulse electric field ablation zone to be treated;
Acquiring a pulse electric field instant ablation region and a thermal field instant ablation region from a pulse electric field ablation range calculation module and a thermal field ablation range calculation module;
Determining whether a partial area of the overlapped area is ablated by a thermal field according to the thermal field instant ablation area, if so, removing the partial area from a pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area, and dynamically adjusting the pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area so that the adjusted pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area are updated regulation targets;
pulse electric field ablation and thermal field ablation are continued until the thermal field ablates the region to be treated and the pulse electric field ablates the region to be treated to be completely ablated.
4. The system of claim 2, the overlapping region being prioritized-free and non-repeating ablation is implemented by:
the method comprises the steps of taking a thermal field ablation zone to be treated and a pulse electric field ablation zone to be treated determined by a treatment ROI zone sketching module as initial regulation and control targets, and determining an overlapping area of the thermal field ablation zone to be treated and the pulse electric field ablation zone to be treated;
Acquiring a pulse electric field instant ablation region and a thermal field instant ablation region from a pulse electric field ablation range calculation module and a thermal field ablation range calculation module;
Determining whether a part of the overlapping area is ablated by the pulse electric field according to the pulse electric field instant ablation area, if so, removing the part of the overlapping area from the pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area, and dynamically adjusting the pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area so that the adjusted pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area are updated regulation targets; or alternatively, the first and second heat exchangers may be,
Determining whether a partial area of the overlapped area is ablated by a thermal field according to the thermal field instant ablation area, if so, removing the partial area from a pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area, and dynamically adjusting the pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area so that the adjusted pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area are updated regulation targets;
pulse electric field ablation and thermal field ablation are continued until the thermal field ablates the region to be treated and the pulse electric field ablates the region to be treated to be completely ablated.
5. The system of claim 2, the overlapping region being prioritized-free and repeatable ablation achieved by:
the method comprises the steps of taking a thermal field ablation zone to be treated and a pulsed electric field ablation zone to be treated, which are determined by a treatment ROI zone sketching module, as regulation and control targets, and determining an overlapping area of the thermal field ablation zone to be treated and the pulsed electric field ablation zone to be treated;
Acquiring a pulse electric field instant ablation region and a thermal field instant ablation region from a pulse electric field ablation range calculation module and a thermal field ablation range calculation module;
when the partial area of the overlapping area is determined to be ablated by the pulse electric field according to the pulse electric field immediate ablation area, the partial area is removed from the pulse electric field ablation to-be-treated area, and the pulse electric field ablation to-be-treated area is dynamically adjusted;
When the fact that the partial area of the overlapped area is ablated by the thermal field is determined according to the thermal field instant ablation area, the partial area is removed from the thermal field ablation to-be-treated area, and the thermal field ablation to-be-treated area is dynamically adjusted;
And taking the adjusted pulse electric field ablation to-be-treated area and the thermal field ablation to-be-treated area as updated regulation targets, and continuously performing pulse electric field ablation and thermal field ablation until the thermal field ablation to-be-treated area and the pulse electric field ablation to-be-treated area are completely ablated.
6. The system of claim 1, wherein the thermal field ablation range calculation module further comprises a temperature acquisition module;
The temperature acquisition module is connected with the ablation needle and used for acquiring temperature information of the ablation needle in real time.
7. The system of claim 1, wherein the pulsed electric field ablation range calculation module further comprises a pulsed electric field ablation therapy information acquisition module;
The pulse electric field ablation treatment information acquisition module is connected with the pulse electric field ablation treatment equipment and is used for acquiring pulse electric field ablation treatment information in real time.
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