CN118005672A

CN118005672A - Synthesis method of silicon-containing electron transport material

Info

Publication number: CN118005672A
Application number: CN202410155669.1A
Authority: CN
Inventors: 吴拥军; 胡俊涛; 黄维洲; 刘仁茂
Original assignee: Xiahe Technology Jiangsu Co ltd
Current assignee: Xiahe Technology Jiangsu Co ltd
Priority date: 2022-10-18
Filing date: 2022-10-18
Publication date: 2024-05-10
Also published as: CN115322215A; CN115322215B

Abstract

The invention provides a synthesis method of a silicon-containing electron transport material, belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of a fused ring compound containing a silicon-doped five-membered ring structure, which comprises the following steps: the structural intermediate Z shown in the formula 2-1 containing the silicon hydrogen group or the formula 2-2 containing the silicon hydrogen group is subjected to intramolecular ring closure reaction in an alcohol solvent under the action of a peroxide reagent M and a reagent Q selected from transition metal oxides or Lewis acid containing transition metal to form a fused silole ring, so that the ring closure reaction with the scale of more than 50 g can achieve unexpectedly high yield, and the method has the excellent characteristics of low reaction temperature, mild condition, low cost and the like, has a shorter synthetic route, and is suitable for industrial production of fused ring compounds containing silicon five-membered ring structures.

Description

Synthesis method of silicon-containing electron transport material

The patent application is a divisional application of China patent application No. 202211269616.X with the application date of 2022, 10 and 18 and the invention name of "a synthesis method of a silicon-containing electron transport material".

Technical Field

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of a silicon-containing electron transport material, in particular to a synthesis method of a fused ring compound containing a silicon-containing five-membered ring structure.

Background

Organic electronic devices include, but are not limited to, the following: organic Light Emitting Diodes (OLEDs), organic field effect transistors (O-FETs), organic Light Emitting Transistors (OLETs), organic photovoltaic devices (OPVs), dye-sensitized solar cells (DSSCs), organic optical detectors, organic photoreceptors, organic field effect devices (OFQDs), light emitting electrochemical cells (LECs), organic laser diodes and organic electroluminescent devices.

Tang and Van Slyke of Isomangan et al reported a double-layered organic electroluminescent device in 1987, which included an arylamine hole transport layer and a tris-8-hydroxyquinoline-aluminum layer as an electron transport layer and a light-emitting layer (APPLIED PHYSICS LETTERS,1987, 51 (12): 913-915). Once biased into the device, green light is emitted from the device. The invention lays a foundation for the development of modern Organic Light Emitting Diodes (OLEDs). Most advanced OLEDs may include multiple layers, such as charge injection and transport layers, charge and exciton blocking layers, and one or more light emitting layers between the cathode and anode. Because OLEDs are self-emitting solid state devices, they offer great potential for display and lighting applications. Furthermore, the inherent properties of organic materials, such as their flexibility, may make them well suited for particular applications, such as fabrication on flexible substrates.

OLEDs can be divided into three different types according to their light emission mechanism. The OLED of Tang and van Slyke invention is a fluorescent OLED. It uses only singlet light emission. The triplet states generated in the device are wasted through non-radiative decay channels. Thus, the Internal Quantum Efficiency (IQE) of fluorescent OLEDs is only 25%. This limitation prevents commercialization of OLEDs. In 1997, forrest and Thompson reported phosphorescent OLEDs using triplet emission from heavy metals containing complexes as emitters. Thus, both singlet and triplet states can be harvested, achieving a 100% IQE. Because of its high efficiency, the discovery and development of phosphorescent OLEDs has contributed directly to the commercialization of Active Matrix OLEDs (AMOLEDs). Recently, adachi achieved high efficiency by Thermally Activated Delayed Fluorescence (TADF) of organic compounds. These emitters have a small singlet-triplet gap, making it possible for excitons to return from the triplet state to the singlet state. In TADF devices, triplet excitons can generate singlet excitons by reverse intersystem crossing, resulting in high IQE.

OLEDs can also be classified into small molecule and polymeric OLEDs depending on the form of the materials used. Small molecule refers to any organic or organometallic material that is not a polymer. The molecular weight of the small molecules can be large as long as they have a precise structure. Dendrimers with a defined structure are considered small molecules. Polymeric OLEDs include conjugated polymers and non-conjugated polymers having pendant luminescent groups. Small molecule OLEDs can become polymeric OLEDs if post-polymerization occurs during fabrication.

Various methods of OLED fabrication exist. Small molecule OLEDs are typically fabricated by vacuum thermal evaporation. Polymeric OLEDs are manufactured by solution processes such as spin coating, inkjet printing and nozzle printing. Small molecule OLEDs can also be fabricated by solution processes if the material can be dissolved or dispersed in a solvent.

The emission color of an OLED can be achieved by the structural design of the luminescent material. The OLED may include a light emitting layer or layers to achieve a desired spectrum. Green, yellow and red OLEDs, phosphorescent materials have been successfully commercialized. Blue phosphorescent devices still have problems of blue unsaturation, short device lifetime, high operating voltage, and the like. Commercial full color OLED displays typically employ a mixing strategy using blue fluorescent and phosphorescent yellow, or red and green. Currently, a rapid decrease in efficiency of phosphorescent OLEDs at high brightness remains a problem. In addition, it is desirable to have a more saturated emission spectrum, higher efficiency and longer device lifetime.

An electron transport material is a functional material necessary for OLED devices, and there is a great deal of research in the industry.

CN111087416a is a previous application by the present inventors, which discloses a fused ring compound containing a silapentad ring structure, which can be used as an excellent electron transport material, and a method for forming a silapentad ring structure by a ring-closing reaction involving a lithium reagent as follows: According to the method, a phenanthrene ring is built through a ring closing reaction, and then a carbon-silicon bond is formed through halogen-lithium exchange to form a silicon-doped five-membered ring, but the synthetic route of the method is longer, and in the prior art, a large amount of butyl lithium is needed for reaction in order to build 2 carbon-silicon bonds in one step, so that the yield is low, and the lithium reagent is very active, has severe reaction conditions and is unfavorable for process amplification.

DIRK LEIFERT in the prior art (org. Lett.2015, 17, 386-389) et al disclose a synthetic method: It only investigated the reaction of substrates of simple structure and does not disclose or teach the use in more complex structures. In addition, this document uses tert-butyl hydroperoxide (TBHP) as the oxidant and CuI or TBAI as the initiator to effect a free radical ring closure reaction in benzene. The prior art considers that the reagents such as CuI and TBAI are beneficial to the reaction due to the support of iodide ions for initiation, and do not disclose or teach different effects caused by other different initiators, and the reaction disclosed in the prior art uses nonpolar benzene as a solvent, has high toxicity, has a reaction yield of less than 70% on a milligram scale, and is not suitable for commercial application.

KR1020130007934a discloses a silicon-containing fused ring compound and discloses a method for synthesizing a fused silole ring structure by rhodium-catalyzed intramolecular ring closure reaction: The method uses an expensive rhodium catalyst RhCl (PPh ₃)₃, high in cost and not suitable for industrial scale-up.

Previous research and development work of the applicant found that fused ring compounds containing a silage five-membered ring structure have important application prospects in the field of electronic materials, but methods in the prior art are not suitable for commercial development of such materials, so that synthesis methods with higher yield, milder conditions and lower cost are required to be deeply developed.

Disclosure of Invention

In view of the shortcomings of the prior art, the present invention aims to provide a method for synthesizing a fused ring compound containing a silage five-membered ring structure, which solves at least part of the above problems. The synthesis method comprises the key step that an intermediate Z is subjected to intramolecular ring closure reaction in an alcohol solvent under the action of a reagent M and a reagent Q to form a fused silole ring, so that the ring closure reaction with the scale of more than 50 g can realize unexpectedly high yield, and the synthesis method has the excellent characteristics of low reaction temperature, mild condition, low cost and the like, has a shorter synthesis route, and is suitable for industrial production of the compounds.

In order to achieve the aim of the invention, the invention adopts the following technical scheme:

The invention provides a method for synthesizing a fused ring compound containing a silicon-containing five-membered ring structure, wherein the fused ring compound has the following structure

A structure represented by formula 1:

wherein n is 1,2, 3 or 4; when n is 2 or more, each group L and B is the same or different;

A has a structure as shown in formula 2:

L is, identically or differently, selected from a single bond, a substituted or unsubstituted arylene group having 6 to 30 carbon atoms, a substituted or unsubstituted heteroarylene group having 3 to 30 carbon atoms, or a combination thereof;

B is selected identically or differently on each occurrence from substituted or unsubstituted electron-deficient heteroaryl groups having 2 to 60 carbon atoms;

The synthesis method comprises the following steps:

intermediate Z undergoes intramolecular ring closure reaction in one or more than one alcohol solvent in the presence of reagent M and reagent Q to form a fused silole ring;

the intermediate Z has a structure as shown in formula 2-1 or formula 2-2:

in the formula 2, the formula 2-1 and the formula 2-2,

T ₁ to T ₁₂ are each independently selected from C, CR _T or N;

R _T、R₁ and R ₂ are selected identically or differently on each occurrence from the group consisting of: hydrogen, deuterium, halogen, substituted or unsubstituted alkyl having 1 to 20 carbon atoms, substituted or unsubstituted cycloalkyl having 3 to 20 ring carbon atoms, substituted or unsubstituted heteroalkyl having 1 to 20 carbon atoms, substituted or unsubstituted heterocyclyl having 3 to 20 ring atoms, substituted or unsubstituted aralkyl having 7 to 30 carbon atoms, substituted or unsubstituted alkoxy having 1 to 20 carbon atoms, substituted or unsubstituted aryloxy having 6 to 30 carbon atoms, substituted or unsubstituted alkenyl having 2 to 20 carbon atoms, substituted or unsubstituted aryl groups having from 6 to 30 carbon atoms, substituted or unsubstituted heteroaryl groups having from 3 to 30 carbon atoms, substituted or unsubstituted alkylsilyl groups having from 3 to 20 carbon atoms, substituted or unsubstituted alkylgermanium groups having from 6 to 20 carbon atoms, substituted or unsubstituted arylgermanium groups having from 6 to 20 carbon atoms, substituted or unsubstituted amino groups having from 0 to 20 carbon atoms, acyl groups, carbonyl groups, ester groups, cyano groups, isocyano groups, hydroxyl groups, mercapto groups, sulfinyl groups, sulfonyl groups, phosphino groups, and combinations thereof;

Adjacent substituents R _T、R₁ and R ₂ can optionally be linked to form a ring;

the reagent M is peroxide;

the reagent Q is selected from a metal oxide or a Lewis acid.

Compared with the prior art, the invention has the following beneficial effects:

The novel synthesis method provided by the invention comprises the key step that an intermediate Z is subjected to intramolecular ring closure reaction in an alcohol solvent under the action of peroxide (reagent M) and reagent Q to form a fused silole ring, so that the ring closure reaction with the scale of more than 50 g can realize unexpectedly high yield, and the novel synthesis method has the excellent characteristics of low reaction temperature, mild condition, low cost and the like, has a shorter synthesis route, and is suitable for industrial production of the fused ring compound with the silicon-hetero five-membered ring structure.

Drawings

FIG. 1 is a schematic view of an organic light emitting device of a compound prepared by a synthetic method according to an embodiment of the present invention;

Fig. 2 is a schematic view of another organic light emitting device of the compound prepared by the synthesis method provided in the embodiment of the present invention.

Detailed Description

The technical scheme of the invention is further described by the following specific embodiments. It will be apparent to those skilled in the art that the examples are merely to aid in understanding the invention and are not to be construed as a specific limitation thereof.

OLEDs can be fabricated on a variety of substrates, such as glass, plastic, and metal. Fig. 1 schematically illustrates, without limitation, an organic light-emitting device 100. The drawings are not necessarily to scale, and some of the layer structures in the drawings may be omitted as desired. The device 100 may include a substrate 101, an anode 110, a hole injection layer 120, a hole transport layer 130, an electron blocking layer 140, a light emitting layer 150, a hole blocking layer 160, an electron transport layer 170, an electron injection layer 180, and a cathode 190. The device 100 may be fabricated by sequentially depositing the layers described. The nature and function of the layers and exemplary materials are described in more detail in U.S. patent No. 7279704B2 at columns 6-10, the entire contents of which are incorporated herein by reference.

There are more instances of each of these layers. For example, a flexible and transparent substrate-anode combination is disclosed in U.S. patent No. 5844363, incorporated by reference in its entirety. An example of a p-doped hole transport layer is m-MTDATA doped with F4-TCNQ at a molar ratio of 50:1, as disclosed in U.S. patent application publication No. 2003/0230980, which is incorporated by reference in its entirety. Examples of host materials are disclosed in U.S. patent No. 6303238 to Thompson et al, which is incorporated by reference in its entirety. An example of an n-doped electron transport layer is BPhen doped with Li in a molar ratio of 1:1 as disclosed in U.S. patent application publication No. 2003/0230980, which is incorporated by reference in its entirety. Examples of cathodes are disclosed in U.S. patent nos. 5703436 and 5707745, which are incorporated by reference in their entirety, which include composite cathodes having a thin layer of metal, such as Mg: ag, with an overlying transparent, electrically conductive, sputter deposited ITO layer. The principles and use of barrier layers are described in more detail in U.S. patent No. 6097147 and U.S. patent application publication No. 2003/0230980, which are incorporated by reference in their entirety. Examples of implant layers are provided in U.S. patent application publication No. 2004/0174116, which is incorporated by reference in its entirety. A description of protective layers can be found in U.S. patent application publication No. 2004/0174116, which is incorporated by reference in its entirety.

The above-described hierarchical structure is provided by way of non-limiting example. The function of the OLED may be achieved by combining the various layers described above, or some of the layers may be omitted entirely. It may also include other layers not explicitly described. Within each layer, a single material or a mixture of materials may be used to achieve optimal performance. Any functional layer may comprise several sublayers. For example, the light emitting layer may have two layers of different light emitting materials to achieve a desired light emission spectrum.

In one embodiment, an OLED may be described as having an "organic layer" disposed between a cathode and an anode. The organic layer may include one or more layers.

The OLED also requires an encapsulation layer, such as the organic light emitting device 200 shown schematically and without limitation in fig. 2, which differs from fig. 1 in that an encapsulation layer 102 may also be included over the cathode 190 to prevent harmful substances from the environment, such as moisture and oxygen. Any material capable of providing an encapsulation function may be used as the encapsulation layer, such as glass or an organic-inorganic hybrid layer. The encapsulation layer should be placed directly or indirectly outside the OLED device. Multilayer film packages are described in U.S. patent No. 7968146B2, the entire contents of which are incorporated herein by reference.

Devices manufactured according to embodiments of the present invention may be incorporated into a variety of consumer products having one or more electronic component modules (or units) of the device. Some examples of such consumer products include flat panel displays, monitors, medical monitors, televisions, billboards, lights for indoor or outdoor lighting and/or signaling, heads-up displays, displays that are fully or partially transparent, flexible displays, smart phones, tablet computers, tablet phones, wearable devices, smart watches, laptops, digital cameras, camcorders, viewfinders, micro-displays, 3-D displays, vehicle displays, and taillights.

The materials and structures described herein may also be used in other organic electronic devices as listed above.

As used herein, "top" means furthest from the substrate and "bottom" means closest to the substrate. In the case where the first layer is described as being "disposed" on "the second layer, the first layer is disposed farther from the substrate. Unless a first layer is "in contact with" a second layer, other layers may be present between the first and second layers. For example, a cathode may be described as "disposed on" an anode even though various organic layers are present between the cathode and the anode.

As used herein, "solution processable" means capable of being dissolved, dispersed, or transported in and/or deposited from a liquid medium in the form of a solution or suspension.

A ligand may be referred to as "photosensitive" when it is believed that the ligand directly contributes to the photosensitive properties of the emissive material. When it is believed that the ligand does not contribute to the photosensitive properties of the emissive material, the ligand may be referred to as "ancillary," but ancillary ligands may alter the properties of the photosensitive ligand.

It is believed that the Internal Quantum Efficiency (IQE) of fluorescent OLEDs can be limited by spin statistics that delay fluorescence by more than 25%. Delayed fluorescence can be generally classified into two types, i.e., P-type delayed fluorescence and E-type delayed fluorescence. The P-type delayed fluorescence is generated by triplet-triplet annihilation (TTA).

On the other hand, the E-type delayed fluorescence does not depend on the collision of two triplet states, but on the transition between the triplet states and the singlet excited state. Compounds capable of generating E-type delayed fluorescence need to have very small mono-triplet gaps in order for the conversion between the energy states. The thermal energy may activate a transition from the triplet state back to the singlet state. This type of delayed fluorescence is also known as Thermally Activated Delayed Fluorescence (TADF). A significant feature of TADF is that the delay component increases with increasing temperature. The fraction of backfill singlet excited states may reach 75% if the reverse intersystem crossing (RISC) rate is fast enough to minimize non-radiative decay from the triplet states. The total singlet fraction may be 100%, well in excess of 25% of the spin statistics of the electrically generated excitons.

Type E delayed fluorescence features can be found in excitation complex systems or in single compounds. Without being bound by theory, it is believed that E-delayed fluorescence requires a luminescent material with a small mono-triplet energy gap (Δe _S-T). Organic non-metal containing donor-acceptor luminescent materials may be able to achieve this. The emission of these materials is typically characterized as donor-acceptor Charge Transfer (CT) type emission. The spatial separation of HOMO from LUMO in these donor-acceptor compounds generally yields a small Δe _S-T. These states may include CT states. Typically, donor-acceptor luminescent materials are constructed by linking an electron donor moiety (e.g., an amino or carbazole derivative) to an electron acceptor moiety (e.g., an N-containing six-membered aromatic ring).

Definition of terms for substituents

Halogen or halide-as used herein, includes fluorine, chlorine, bromine and iodine.

Alkyl-as used herein, includes straight and branched chain alkyl groups. The alkyl group may be an alkyl group having 1 to 20 carbon atoms, preferably an alkyl group having 1 to 12 carbon atoms, more preferably an alkyl group having 1 to 6 carbon atoms. Examples of alkyl groups include methyl, ethyl, propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, n-nonyl, n-decyl, n-undecyl, n-dodecyl, n-tridecyl, n-tetradecyl, n-pentadecyl, n-hexadecyl, n-heptadecyl, n-octadecyl, neopentyl, 1-methylpentyl, 2-methylpentyl, 1-pentylhexyl, 1-butylpentyl, 1-heptyloctyl, 3-methylpentyl. Among the above, methyl, ethyl, propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, neopentyl and n-hexyl are preferred. In addition, the alkyl group may be optionally substituted.

Cycloalkyl-as used herein, includes cyclic alkyl. Cycloalkyl groups may be cycloalkyl groups having 3 to 20 ring carbon atoms, preferably 4 to 10 carbon atoms. Examples of cycloalkyl groups include cyclobutyl, cyclopentyl, cyclohexyl, 4-methylcyclohexyl, 4-dimethylcyclohexyl, 1-adamantyl, 2-adamantyl, 1-norbornyl, 2-norbornyl and the like. Among the above, cyclopentyl, cyclohexyl, 4-methylcyclohexyl, 4-dimethylcyclohexyl are preferred. In addition, cycloalkyl groups may be optionally substituted.

Heteroalkyl-as used herein, a heteroalkyl comprises an alkyl chain in which one or more carbons is replaced by a heteroatom selected from the group consisting of nitrogen, oxygen, sulfur, selenium, phosphorus, silicon, germanium, and boron. The heteroalkyl group may be a heteroalkyl group having 1 to 20 carbon atoms, preferably a heteroalkyl group having 1 to 10 carbon atoms, more preferably a heteroalkyl group having 1 to 6 carbon atoms. Examples of heteroalkyl groups include methoxymethyl, ethoxymethyl, ethoxyethyl, methylthiomethyl, ethylthiomethyl, ethylthioethyl, methoxymethoxymethyl, ethoxymethoxymethyl, ethoxyethoxyethyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, mercaptomethyl, mercaptoethyl, mercaptopropyl, aminomethyl, aminoethyl, aminopropyl, dimethylaminomethyl, trimethylgermylmethyl, trimethylgermylethyl, dimethylethylgermylmethyl, dimethylisopropylgermylmethyl, t-butyldimethylgermylmethyl, triethylgermylmethyl, triethylgermylethyl, triisopropylgermylmethyl, triisopropylgermylethyl, trimethylsilylmethyl, trimethylsilylethyl, trimethylsilylisopropyl, triisopropylsilylmethyl. In addition, heteroalkyl groups may be optionally substituted.

Alkenyl-as used herein, covers straight chain, branched chain, and cyclic alkylene groups. Alkenyl groups may be alkenyl groups containing 2 to 20 carbon atoms, preferably alkenyl groups having 2 to 10 carbon atoms. Examples of alkenyl groups include ethenyl, propenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1, 3-butadienyl, 1-methylvinyl, styryl, 2-diphenylvinyl, 1-methallyl, 1-dimethylallyl, 2-methallyl, 1-phenylallyl, 2-phenylallyl, 3-diphenylallyl, 1, 2-dimethylallyl, 1-phenyl-1-butenyl, 3-phenyl-1-butenyl, cyclopentenyl, cyclopentadienyl, cyclohexenyl, cycloheptenyl, cycloheptatrienyl, cyclooctenyl, cyclooctatetraenyl and norbornenyl. In addition, alkenyl groups may be optionally substituted.

Alkynyl-as used herein, straight chain alkynyl is contemplated. The alkynyl group may be an alkynyl group containing 2 to 20 carbon atoms, preferably an alkynyl group having 2 to 10 carbon atoms. Examples of alkynyl groups include ethynyl, propynyl, propargyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-pentynyl, 2-pentynyl, 3-dimethyl-1-butynyl, 3-ethyl-3-methyl-1-pentynyl, 3-diisopropyl-1-pentynyl, phenylethynyl, phenylpropynyl and the like. Among the above, preferred are ethynyl, propynyl, propargyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-pentynyl and phenylethynyl. In addition, alkynyl groups may be optionally substituted.

Aryl or aromatic-as used herein, non-fused and fused systems are contemplated. The aryl group may be an aryl group having 6 to 30 carbon atoms, preferably an aryl group having 6 to 20 carbon atoms, more preferably an aryl group having 6 to 12 carbon atoms. Examples of the aryl group include phenyl, biphenyl, terphenyl, triphenylene, tetraphenylene, naphthalene, anthracene, phenalene, phenanthrene, fluorene, pyrene,Perylene and azulene, preferably phenyl, biphenyl, terphenyl, triphenylene, fluorene and naphthalene. Examples of non-condensed aryl groups include phenyl, biphenyl-2-yl, biphenyl-3-yl, biphenyl-4-yl, p-terphenyl-3-yl, p-terphenyl-2-yl, m-terphenyl-4-yl, m-terphenyl-3-yl, m-terphenyl-2-yl, o-tolyl, m-tolyl, p- (2-phenylpropyl) phenyl, 4 '-methylbiphenyl-4' -tert-butyl-p-terphenyl-4-yl, o-cumyl, m-cumyl, p-cumyl, 2, 3-xylyl, 3, 4-xylyl, 2, 5-xylyl, mesityl and m-tetrabiphenyl. In addition, aryl groups may be optionally substituted.

Heterocyclyl or heterocycle-as used herein, non-aromatic cyclic groups are contemplated. The non-aromatic heterocyclic group includes a saturated heterocyclic group having 3 to 20 ring atoms and an unsaturated non-aromatic heterocyclic group having 3 to 20 ring atoms, at least one of which is selected from the group consisting of nitrogen atom, oxygen atom, sulfur atom, selenium atom, silicon atom, phosphorus atom, germanium atom and boron atom, and preferred non-aromatic heterocyclic groups are those having 3 to 7 ring atoms including at least one hetero atom such as nitrogen, oxygen, silicon or sulfur. Examples of non-aromatic heterocyclic groups include oxiranyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, dioxanyl, aziridinyl, dihydropyrrolyl, tetrahydropyrrolyl, piperidinyl, oxazolidinyl, morpholinyl, piperazinyl, oxacycloheptatrienyl, thietaneyl, azepanyl and tetrahydrosilol. In addition, the heterocyclic group may be optionally substituted.

Heteroaryl-as used herein, non-fused and fused heteroaromatic groups that may contain 1 to 5 heteroatoms, at least one of which is selected from the group consisting of nitrogen atoms, oxygen atoms, sulfur atoms, selenium atoms, silicon atoms, phosphorus atoms, germanium atoms, and boron atoms. Heteroaryl also refers to heteroaryl. The heteroaryl group may be a heteroaryl group having 3 to 30 carbon atoms, preferably a heteroaryl group having 3 to 20 carbon atoms, more preferably a heteroaryl group having 3 to 12 carbon atoms. Suitable heteroaryl groups include dibenzothiophene, dibenzofuran, dibenzoselenophene, furan, thiophene, benzofuran, benzothiophene, benzoselenophene, carbazole, indolocarbazole, pyridine indole, pyrrolopyridine, pyrazole, imidazole, triazole, oxazole, thiazole, oxadiazole, oxazole, dioxazole, thiadiazole, pyridine, pyridazine, pyrimidine, pyrazine, triazine, oxazine, oxathiazine, oxadiazine, indole, benzimidazole, indazole, indenoxazine, benzoxazole, benzisoxazole, benzothiazole, quinoline, isoquinoline, cinnoline, quinazoline, quinoxaline, naphthyridine, phthalazine, pteridine, xanthene, acridine, phenazine, phenothiazine, benzofuranopyridine, furodipyridine, benzothiophene, thienodipyridine, benzoselenophene, selenodipyridine, preferably dibenzothiophene, dibenzofuran, dibenzoselenophene, carbazole, indolocarbazole, imidazole, pyridine, triazine, benzimidazole, 1, 2-aza-boron, 1, 3-aza-boron, 1-aza-boron-4-aza, boron-doped compounds, and the like. In addition, heteroaryl groups may be optionally substituted.

Alkoxy-as used herein, is represented by-O-alkyl, -O-cycloalkyl, -O-heteroalkyl, or-O-heterocyclyl. Examples and preferred examples of the alkyl group, cycloalkyl group, heteroalkyl group and heterocyclic group are the same as described above. The alkoxy group may be an alkoxy group having 1 to 20 carbon atoms, preferably an alkoxy group having 1 to 6 carbon atoms. Examples of alkoxy groups include methoxy, ethoxy, propoxy, butoxy, pentoxy, hexyloxy, cyclopropyloxy, cyclobutyloxy, cyclopentyloxy, cyclohexyloxy, tetrahydrofuranyloxy, tetrahydropyranyloxy, methoxypropyloxy, ethoxyethyloxy, methoxymethyloxy and ethoxymethyloxy. In addition, the alkoxy group may be optionally substituted.

Aryloxy-as used herein, is represented by-O-aryl or-O-heteroaryl. Examples and preferred examples of aryl and heteroaryl groups are the same as described above. The aryloxy group may be an aryloxy group having 6 to 30 carbon atoms, preferably an aryloxy group having 6 to 20 carbon atoms. Examples of aryloxy groups include phenoxy and biphenoxy. In addition, the aryloxy group may be optionally substituted.

Aralkyl-as used herein, encompasses aryl-substituted alkyl. The aralkyl group may be an aralkyl group having 7 to 30 carbon atoms, preferably an aralkyl group having 7 to 20 carbon atoms, more preferably an aralkyl group having 7 to 13 carbon atoms. Examples of aralkyl groups include benzyl, 1-phenylethyl, 2-phenylethyl, 1-phenylisopropyl, 2-phenylisopropyl, phenyl tert-butyl, α -naphthylmethyl, 1- α -naphthyl-ethyl, 2- α -naphthylethyl, 1- α -naphthylisopropyl, 2- α -naphthylisopropyl, β -naphthylmethyl, 1- β -naphthyl-ethyl, 2- β -naphthyl-ethyl, 1- β -naphthylisopropyl, 2- β -naphthylisopropyl, p-methylbenzyl, m-methylbenzyl, o-methylbenzyl, p-chlorobenzyl, m-chlorobenzyl, o-chlorobenzyl, p-bromobenzyl, m-bromobenzyl, o-bromobenzyl, p-iodobenzyl, m-iodobenzyl, o-iodobenzyl, p-hydroxybenzyl, m-hydroxybenzyl, o-aminobenzyl, m-aminobenzyl, o-aminobenzyl, p-nitrobenzyl, m-nitrobenzyl, o-nitrobenzyl, p-cyanobenzyl, m-cyanobenzyl, cyano, o-cyanobenzyl, o-chlorobenzyl, 1-chlorophenyl and 1-isopropyl. Among the above, preferred are benzyl, p-cyanobenzyl, m-cyanobenzyl, o-cyanobenzyl, 1-phenylethyl, 2-phenylethyl, 1-phenylisopropyl and 2-phenylisopropyl. In addition, aralkyl groups may be optionally substituted.

Alkyl-as used herein, alkyl-substituted silicon groups are contemplated. The silyl group may be a silyl group having 3 to 20 carbon atoms, preferably a silyl group having 3 to 10 carbon atoms. Examples of the alkyl silicon group include trimethyl silicon group, triethyl silicon group, methyldiethyl silicon group, ethyldimethyl silicon group, tripropyl silicon group, tributyl silicon group, triisopropyl silicon group, methyldiisopropyl silicon group, dimethylisopropyl silicon group, tri-t-butyl silicon group, triisobutyl silicon group, dimethyl-t-butyl silicon group, and methyldi-t-butyl silicon group. In addition, the alkyl silicon group may be optionally substituted.

Arylsilane-as used herein, encompasses at least one aryl-substituted silicon group. The arylsilane group may be an arylsilane group having 6 to 30 carbon atoms, preferably an arylsilane group having 8 to 20 carbon atoms. Examples of arylsilyl groups include triphenylsilyl, phenyldiphenylsilyl, diphenylbiphenyl silyl, phenyldiethylsilyl, diphenylethylsilyl, phenyldimethylsilyl, diphenylmethylsilyl, phenyldiisopropylsilyl, diphenylisopropylsilyl, diphenylbutylsilyl, diphenylisobutylsilyl, diphenyltert-butylsilyl. In addition, arylsilane groups may be optionally substituted.

Alkyl germanium group-as used herein, alkyl substituted germanium groups are contemplated. The alkylgermanium group may be an alkylgermanium group having 3 to 20 carbon atoms, preferably an alkylgermanium group having 3 to 10 carbon atoms. Examples of alkyl germanium groups include trimethyl germanium group, triethyl germanium group, methyl diethyl germanium group, ethyl dimethyl germanium group, tripropyl germanium group, tributyl germanium group, triisopropyl germanium group, methyl diisopropyl germanium group, dimethyl isopropyl germanium group, tri-t-butyl germanium group, triisobutyl germanium group, dimethyl-t-butyl germanium group, methyl-di-t-butyl germanium group. In addition, alkyl germanium groups may be optionally substituted.

Arylgermanium group-as used herein, encompasses at least one aryl or heteroaryl substituted germanium group. The arylgermanium group may be an arylgermanium group having 6-30 carbon atoms, preferably an arylgermanium group having 8 to 20 carbon atoms. Examples of aryl germanium groups include triphenylgermanium group, phenylbiphenyl germanium group, diphenylbiphenyl germanium group, phenyldiethyl germanium group, diphenylethyl germanium group, phenyldimethyl germanium group, diphenylmethyl germanium group, phenyldiisopropylgermanium group, diphenylisopropylgermanium group, diphenylbutylgermanium group, diphenylisobutylglycol group, and diphenyltert-butylgermanium group. In addition, the arylgermanium group may be optionally substituted.

The term "aza" in azadibenzofurans, azadibenzothiophenes and the like means that one or more C-H groups in the corresponding aromatic fragment are replaced by a nitrogen atom. For example, azatriphenylenes include dibenzo [ f, h ] quinoxalines, dibenzo [ f, h ] quinolines, and other analogs having two or more nitrogens in the ring system. Other nitrogen analogs of the above-described aza derivatives will be readily apparent to those of ordinary skill in the art, and all such analogs are intended to be included in the terms described herein.

In this document, unless otherwise defined, when any one term from the group consisting of: substituted alkyl, substituted cycloalkyl, substituted heteroalkyl, substituted heterocyclyl, substituted aralkyl, substituted alkoxy, substituted aryloxy, substituted alkenyl, substituted alkynyl, substituted aryl, substituted heteroaryl, substituted alkylsilyl, substituted arylsilyl, substituted alkylgermanium, substituted arylgermanium, substituted amino, substituted acyl, substituted carbonyl, substituted carboxylic acid, substituted ester, substituted sulfinyl, substituted sulfonyl, substituted phosphino, alkyl, cycloalkyl, heteroalkyl, heterocyclyl, aralkyl, alkoxy, aryloxy, alkenyl, alkynyl, aryl, heteroaryl, alkylsilyl, arylsilyl, amino, acyl, carbonyl, carboxylic acid, ester, sulfinyl, sulfonyl and phosphino groups, which may be substituted with one or more groups selected from the group consisting of deuterium, halogen, unsubstituted alkyl having 1 to 20 carbon atoms, unsubstituted cycloalkyl having 3 to 20 ring carbon atoms, unsubstituted cycloalkyl having 1 to 20 carbon atoms, unsubstituted alkenyl having 3 to 20 carbon atoms, unsubstituted aryl having 3 to 20 carbon atoms, unsubstituted alkenyl having 3 to 30 carbon atoms, unsubstituted aryl having 3 to 20 carbon atoms, unsubstituted alkenyl having 3 to 20 carbon atoms, unsubstituted aryl having 3 to 30 carbon atoms, unsubstituted aryl having 3 to 20 carbon atoms, unsubstituted aryl having 3 to 30 carbon atoms, unsubstituted alkylgermanium groups having 3 to 20 carbon atoms, unsubstituted arylgermanium groups having 6 to 20 carbon atoms, unsubstituted amino groups having 0 to 20 carbon atoms, acyl groups, carbonyl groups, carboxylic acid groups, ester groups, cyano groups, isocyano groups, hydroxyl groups, mercapto groups, sulfinyl groups, sulfonyl groups, phosphine groups, and combinations thereof.

It will be appreciated that when a fragment of a molecule is described as a substituent or otherwise attached to another moiety, its name may be written according to whether it is a fragment (e.g., phenyl, phenylene, naphthyl, dibenzofuranyl) or according to whether it is an entire molecule (e.g., benzene, naphthalene, dibenzofuran). As used herein, these different ways of specifying substituents or linking fragments are considered equivalent.

In the compounds mentioned herein, the hydrogen atoms may be partially or completely replaced by deuterium. Other atoms such as carbon and nitrogen may also be replaced by their other stable isotopes. Substitution of other stable isotopes in the compounds may be preferred because of their enhanced efficiency and stability of the device.

In the compounds mentioned herein, polysubstituted means inclusive of disubstituted up to the maximum available substitution range. When a substituent in a compound mentioned in this disclosure means multiple substitution (including di-substitution, tri-substitution, tetra-substitution, etc.), it means that the substituent may be present at a plurality of available substitution positions on its linking structure, and the substituent present at each of the plurality of available substitution positions may be of the same structure or of different structures.

In the compounds mentioned herein, adjacent substituents cannot be linked to form a ring unless explicitly defined, for example, adjacent substituents can be optionally linked to form a ring. In the compounds mentioned in this disclosure, adjacent substituents can optionally be linked to form a ring, both in the case where adjacent substituents can be linked to form a ring and in the case where adjacent substituents are not linked to form a ring. Where adjacent substituents can optionally be joined to form a ring, the ring formed can be monocyclic or polycyclic (including spiro, bridged, fused, etc.), as well as alicyclic, heteroalicyclic, aromatic or heteroaromatic. In this expression, adjacent substituents may refer to substituents bonded to the same atom, substituents bonded to carbon atoms directly bonded to each other, or substituents bonded to further distant carbon atoms. Preferably, adjacent substituents refer to substituents bonded to the same carbon atom and substituents bonded to carbon atoms directly bonded to each other.

The expression that adjacent substituents can optionally be linked to form a ring is also intended to mean that two substituents bonded to the same carbon atom are linked to each other by a chemical bond to form a ring, which can be exemplified by the following formula:

the expression that adjacent substituents can optionally be linked to form a ring is also intended to be taken to mean that two substituents bonded to carbon atoms directly bonded to each other are linked to each other by a chemical bond to form a ring, which can be exemplified by the following formula:

The expression that adjacent substituents can optionally be linked to form a ring is also intended to be taken to mean that the two substituents bound to further distant carbon atoms are linked to each other by a chemical bond to form a ring, which can be exemplified by the following formula:

furthermore, the expression that adjacent substituents can optionally be linked to form a ring is also intended to be taken to mean that, in the case where one of the adjacent two substituents represents hydrogen, the second substituent is bonded at the position to which the hydrogen atom is bonded, thereby forming a ring. This is exemplified by the following formula:

According to an embodiment of the present invention, there is disclosed a method for synthesizing a condensed-cyclic compound including a silafive-membered ring structure, wherein the condensed-cyclic compound has a structure as shown in formula 1:

A has a structure as shown in formula 2:

The synthesis method comprises the following steps:

the intermediate Z has a structure as shown in formula 2-1 or formula 2-2:

in the formula 2, the formula 2-1 and the formula 2-2,

T ₁ to T ₁₂ are each independently selected from C, CR _T or N;

the reagent M is peroxide;

the reagent Q is selected from a transition metal oxide or a transition metal-containing Lewis acid.

Herein, the reagent M is an oxidizing agent, and plays a role in oxidization; the reagent Q is an initiator and plays a role in initiating reaction.

Herein, adjacent substituents R _T、R₁、R₂ can optionally be linked to form a ring, intended to mean wherein any one or more of the adjacent groups of substituents, for example, between adjacent substituents R _T, between adjacent substituents R ₁ and R ₂, between adjacent substituents R _T and R ₁, and between adjacent substituents R _T and R ₂, can be linked to form a ring. Obviously, any adjacent substituents R _T、R₁、R₂ may not all be linked to form a ring.

Suitable electron-deficient heteroaryl groups herein include pyridine indole, pyrrole pyridine, pyrazole, imidazole, triazole, oxazole, thiazole, oxadiazole, oxazole, dioxazole, thiadiazole, pyridine, pyridazine, pyrimidine, pyrazine, triazine, oxazine, oxathiazine, phenanthroline, azaphenanthroline and aza analogues thereof, oxadiazine, benzimidazole, indazole, indenazine, benzoxazole, benzisoxazole, benzothiazole, quinoline, isoquinoline, cinnoline, quinazoline, quinoxaline, naphthyridine, phthalazine, benzofuranopyridine, furodipyridine, benzothiophenopyridine, thienodipyridine, benzoselenophenopyridine, 1, 2-azaborane, 1, 3-azaborane, 1, 4-azaborane, borazole and aza analogues thereof.

According to one embodiment of the present invention, when the intermediate Z has a structure as shown in formula 2-1, the intermediate Z undergoes an intramolecular ring closure reaction to obtain an intermediate A ', and the synthesis method further includes a step of reacting the intermediate A' with n intermediates including L-B structures to obtain the condensed-cyclic compound.

According to one embodiment of the present invention, the step of reacting the intermediate A' with n intermediates containing L-B structures to obtain the fused ring compound includes a step of cross coupling (cross coupling) catalyzed by a transition metal catalyst.

In this embodiment, the cross-coupling (cross coupling) catalyzed by the transition metal catalyst may occur by the halogenated derivative of the intermediate A '(e.g., chlorinated A', brominated A ', or iodinated A') with n halogenated derivatives comprising L-B structure (e.g., B-L-boric acid, B-L-borate, B-L-magnesium halide, B-L-zinc halide, or B-L-tin) catalyzed by a transition metal catalyst (e.g., palladium, copper, rhodium, or ruthenium-containing catalyst), or by the halogenated derivative of the intermediate A '(e.g., A' -boric acid, A '-borate, A' -magnesium halide, A '-zinc halide, or A' -tin) catalyzed by n halogenated derivatives comprising L-B structure (e.g., B-L-chlorine, B-L-bromine, or B-L-iodine) catalyzed by a transition metal catalyst (e.g., palladium, copper, rhodium, or ruthenium-containing catalyst); the methods of cross-coupling catalyzed by such transition metal catalysts are well known to those skilled in the art and will not be described in detail herein.

According to one embodiment of the present invention, when the intermediate Z has a structure as shown in formula 2-2, the intermediate Z undergoes an intramolecular ring-closing reaction to obtain the condensed-cyclic compound; the intermediate Z is obtained by reacting an intermediate Z' with a structure of formula 2-1 with n intermediates containing L-B structures.

According to one embodiment of the present invention, when the intermediate Z has a structure as shown in formula 2-2, the intermediate Z is obtained by reacting an intermediate having a structure as shown in formula 2-1 with n intermediates including L-B structures, and the step of reacting an intermediate having a structure as shown in formula 2-1 with n intermediates including L-B structures to obtain the intermediate Z includes a step of cross coupling catalyzed by a transition metal catalyst.

In this embodiment, the cross-coupling (cross coupling) catalyzed by the transition metal catalyst may occur by the halogenated derivative (e.g., chlorinated Z ', brominated Z' or iodinated Z ') of the intermediate having the structure of formula 2-1 (intermediate Z') with n halogenated derivatives (e.g., B-L-boric acid, B-L-borate, B-L-magnesium halide, B-L-zinc halide or B-L-tin) comprising the structure of L-B under the catalysis of a transition metal catalyst (e.g., a catalyst comprising palladium, copper, rhodium or ruthenium), or by the catalysis of a metal reagent derivative (e.g., Z '-boric acid, Z' -borate, Z '-magnesium halide, Z' -zinc halide or Z '-tin) of the intermediate Z') with n halogenated derivatives (e.g., B-L-chlorine, B-L-bromine or B-L-iodine) comprising the structure of L-B under the catalysis of a transition metal catalyst (e.g., a catalyst comprising palladium, copper, rhodium or ruthenium); the methods of cross-coupling catalyzed by such transition metal catalysts are well known to those skilled in the art and will not be described in detail herein.

According to one embodiment of the invention, the R ₁、R₂ groups are selected identically or differently on each occurrence from substituted or unsubstituted aryl groups having from 6 to 30 carbon atoms, substituted or unsubstituted heteroaryl groups having from 3 to 30 carbon atoms.

According to one embodiment of the present invention, the a has a structure as shown in formula 3:

Wherein T ₁ to T ₂₂ are each independently selected from C, CR _T or N;

R _T is selected identically or differently on each occurrence from the group consisting of: hydrogen, deuterium, halogen, substituted or unsubstituted alkyl having 1 to 20 carbon atoms, substituted or unsubstituted cycloalkyl having 3 to 20 ring carbon atoms, substituted or unsubstituted heteroalkyl having 1 to 20 carbon atoms, substituted or unsubstituted heterocyclyl having 3 to 20 ring atoms, substituted or unsubstituted aralkyl having 7 to 30 carbon atoms, substituted or unsubstituted alkoxy having 1 to 20 carbon atoms, substituted or unsubstituted aryloxy having 6 to 30 carbon atoms, substituted or unsubstituted alkenyl having 2 to 20 carbon atoms, substituted or unsubstituted aryl groups having from 6 to 30 carbon atoms, substituted or unsubstituted heteroaryl groups having from 3 to 30 carbon atoms, substituted or unsubstituted alkylsilyl groups having from 3 to 20 carbon atoms, substituted or unsubstituted alkylgermanium groups having from 6 to 20 carbon atoms, substituted or unsubstituted arylgermanium groups having from 6 to 20 carbon atoms, substituted or unsubstituted amino groups having from 0 to 20 carbon atoms, acyl groups, carbonyl groups, ester groups, cyano groups, isocyano groups, hydroxyl groups, mercapto groups, sulfinyl groups, sulfonyl groups, phosphino groups, and combinations thereof;

Adjacent substituents R _T can optionally be linked to form a ring.

Herein, adjacent substituents R _T can optionally be linked to form a ring, intended to mean wherein any adjacent substituent R _T can be linked to form a ring. Obviously, any adjacent substituents R _T may not all be linked to form a ring.

According to one embodiment of the invention, the L is selected from a single bond, a substituted or unsubstituted arylene group having 6 to 20 carbon atoms, a substituted or unsubstituted heteroarylene group having 3 to 20 carbon atoms, or a combination thereof.

According to one embodiment of the invention, the L is selected from the group consisting of a single bond and formulas 4 to 28:

Wherein the dotted line represents the attachment site of the group;

R ₃、R₄、R₅ and R ₆ each independently represent a single substituent, multiple substituents or no substituent; adjacent substituents R ₃、R₄、R₅ and R ₆ can optionally be linked to form a ring;

R ₃、R₄、R₅ and R ₆ are each independently selected from the group consisting of: hydrogen, deuterium, halogen, substituted or unsubstituted alkyl having 1 to 20 carbon atoms, substituted or unsubstituted cycloalkyl having 3 to 20 ring carbon atoms, substituted or unsubstituted heteroalkyl having 1 to 20 carbon atoms, substituted or unsubstituted heterocyclyl having 3 to 20 ring atoms, substituted or unsubstituted aralkyl having 7 to 30 carbon atoms, substituted or unsubstituted alkoxy having 1 to 20 carbon atoms, substituted or unsubstituted aryloxy having 6 to 30 carbon atoms, substituted or unsubstituted alkenyl having 2 to 20 carbon atoms, substituted or unsubstituted aryl groups having from 6 to 30 carbon atoms, substituted or unsubstituted heteroaryl groups having from 3 to 30 carbon atoms, substituted or unsubstituted alkylsilyl groups having from 3 to 20 carbon atoms, substituted or unsubstituted arylsilyl groups having from 6 to 20 carbon atoms, substituted or unsubstituted alkylgermanium groups having from 3 to 20 carbon atoms, substituted or unsubstituted arylgermanium groups having from 6 to 20 carbon atoms, substituted or unsubstituted amino groups having from 0 to 20 carbon atoms, acyl groups, carbonyl groups, ester groups, cyano groups, isocyano groups, hydroxyl groups, mercapto groups, sulfinyl groups, sulfonyl groups, phosphino groups, and combinations thereof.

In this embodiment, adjacent substituents R ₃、R₄、R₅ and R ₆ can optionally be linked to form a ring, which is intended to mean wherein any one or more of the adjacent substituent groups, for example, between adjacent substituents R ₃, between adjacent substituents R ₄, between adjacent substituents R ₅, between adjacent substituents R ₆, between adjacent substituents R ₃ and R ₄, between adjacent substituents R ₃ and R ₅, between adjacent substituents R ₃ and R ₆, between adjacent substituents R ₄ and R ₅, between adjacent substituents R ₄ and R ₆, and between adjacent substituents R ₅ and R ₆, can be linked to form a ring. Obviously, none of these adjacent groups of substituents may be linked to form a ring.

According to one embodiment of the invention, said B is selected from the group consisting of formulae 29 to 33:

Wherein the dotted line represents the attachment site of the group;

X ₁ to X ₆ are each independently selected from CR _X, C or N;

y ₁ is selected from O, S or NR _X';

At least one of X ₁ to X _i is N; the X _i corresponds to the largest sequence number of the X ₁ to X ₆ present in formulas 29 to 33;

R ₇ each independently represents mono-, poly-or unsubstituted; adjacent substituents R ₇ can optionally be linked to form a ring;

R ₇、R_X and R _X' are each independently selected from the group consisting of: hydrogen, deuterium, halogen, substituted or unsubstituted alkyl having 1 to 20 carbon atoms, substituted or unsubstituted cycloalkyl having 3 to 20 ring carbon atoms, substituted or unsubstituted heteroalkyl having 1 to 20 carbon atoms, substituted or unsubstituted heterocyclyl having 3 to 20 ring atoms, substituted or unsubstituted aralkyl having 7 to 30 carbon atoms, substituted or unsubstituted alkoxy having 1 to 20 carbon atoms, substituted or unsubstituted aryloxy having 6 to 30 carbon atoms, substituted or unsubstituted alkenyl having 2 to 20 carbon atoms, substituted or unsubstituted aryl groups having from 6 to 30 carbon atoms, substituted or unsubstituted heteroaryl groups having from 3 to 30 carbon atoms, substituted or unsubstituted alkylsilyl groups having from 3 to 20 carbon atoms, substituted or unsubstituted arylsilyl groups having from 6 to 20 carbon atoms, substituted or unsubstituted alkylgermanium groups having from 3 to 20 carbon atoms, substituted or unsubstituted arylgermanium groups having from 6 to 20 carbon atoms, substituted or unsubstituted amino groups having from 0 to 20 carbon atoms, acyl groups, carbonyl groups, ester groups, cyano groups, isocyano groups, hydroxyl groups, mercapto groups, sulfinyl groups, sulfonyl groups, phosphino groups, and combinations thereof.

In this embodiment, at least one of X ₁ to X _i is N, and the X _i corresponds to the one with the largest sequence number of the X ₁ to X ₆ in the formulae 29 to 33; for example, for formula 29, the X _i corresponds to the largest sequence number X ₃ present in formula 29, i.e., at least one of X ₁ to X ₃ in formula 29 is N; for another example, at least one of X ₁ to X ₄ in formula 30 is N and at least one of X ₁ to X ₆ in formula 31 is N. It is similar that at least two of X ₁ to X _i are N or at least three of X ₁ to X _i are N in formulas 29 to 33.

Herein, adjacent substituents R ₇ can optionally be linked to form a ring, intended to mean wherein any adjacent substituent R ₇ can be linked to form a ring. Obviously, any adjacent substituents R ₇ may not all be linked to form a ring.

According to one embodiment of the present invention, the condensed-cyclic compound has a structure as shown in formula 1:

Wherein n is 1 or 2;

The a is selected from the group consisting of A1 to a 50:

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Each of said B is independently selected from the group consisting of B1 to B105:

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each L is independently selected from the group consisting of L0 to L58:

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According to one embodiment of the invention, the fused ring compound is selected from the group consisting of compound 1 to compound 270; the specific structures of the compounds 1 to 270 are shown in the following table 1; wherein A, L, B and n correspond to the structures and numbers listed in the table, respectively.

Table 1 specific structures of compounds 1 through 270

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According to one embodiment of the invention, the reagent M is t-butyl hydroperoxide (t-butyl peroxy alcohol, TBHP).

According to one embodiment of the invention, the amount of the substance of the reagent M is 3-10 times the amount of the substance of the intermediate Z, for example 3.5 times, 4 times, 4.5 times, 5 times, 5.5 times, 6 times, 6.5 times, 7 times, 7.5 times, 8 times, 8.5 times, 9 times or 9.5 times, etc.

According to one embodiment of the invention, the amount of substance of reagent M is 3-5 times the amount of substance of intermediate Z.

According to one embodiment of the invention, the reagent M is added in portions.

According to one embodiment of the invention, the reagent Q is selected from copper oxide, copper-containing lewis acid, iron-containing lewis acid or cobalt-containing lewis acid.

According to one embodiment of the invention, the reagent Q is selected from copper (II) acetylacetonate (Cu (acac) ₂), iron (Fe (acac) ₃), cobalt dichloride (CoCl ₂), copper cyanide (CuCN), copper (I) thiophene-2-carboxylate (CuTc), copper acetate (Cu (OAc) ₂), copper trifluoromethane sulfonate (Cu (OTf) ₂), copper (II) acetoacetate (Cu (eacac) ₂), copper oxide (Cu ₂ O) or copper bis (2, 6-tetramethyl-3, 5-heptanedione) oxide (Cu (TMHD) ₂).

According to one embodiment of the invention, the reagent Q is selected from metal salts.

According to one embodiment of the invention, the reagent Q is selected from the group consisting of cupric salts.

According to one embodiment of the invention, the reagent Q does not contain iodide ions.

According to one embodiment of the invention, the amount of substance of reagent Q is 1% -100% of the amount of substance of intermediate Z, for example 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90% or 95% etc.

According to one embodiment of the invention, the amount of substance of reagent Q is 1% -50% of the amount of substance of intermediate Z.

According to one embodiment of the invention, the amount of substance of reagent Q is 1% -30% of the amount of substance of intermediate Z.

According to one embodiment of the invention, the amount of substance of reagent Q is 5% -30% of the amount of substance of intermediate Z.

According to one embodiment of the invention, the amount of substance of reagent Q is 20% of the amount of substance of intermediate Z.

According to one embodiment of the present invention, the alcoholic solvent is selected from any one or a combination of at least two of methanol, ethanol, n-propanol, isopropanol, n-butanol, t-amyl alcohol, 2-methoxyethanol, 2-ethoxyethanol.

According to one embodiment of the present invention, the alcohol solvent is a mixture of two or more solvents selected from methanol, ethanol, n-propanol, isopropanol, n-butanol, t-amyl alcohol, 2-methoxyethanol or 2-ethoxyethanol in an arbitrary ratio.

According to an embodiment of the present invention, the reaction temperature of the intramolecular ring closure reaction is room temperature to 100 ℃, and may be, for example, 15 ℃, 20 ℃,25 ℃, 30 ℃, 35 ℃, 40 ℃, 45 ℃, 50 ℃, 55 ℃, 60 ℃, 65 ℃, 70 ℃, 75 ℃, 80 ℃, 85 ℃, 90 ℃, 95 ℃, or the like.

According to one embodiment of the invention, the reaction temperature of the intramolecular cyclization reaction is from room temperature to 80 ℃.

According to one embodiment of the present invention, the intramolecular cyclization reaction has a reaction temperature of 50℃to 70 DEG C

According to one embodiment of the invention, the intramolecular cyclization reaction has a reaction temperature of 60 ℃.

According to one embodiment of the present invention, in the synthesis method, the yield of the intermediate Z in which the intramolecular ring closure reaction forms a fused silole ring is greater than 60%, for example, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 98%, etc.

According to one embodiment of the invention, in the synthesis method, the yield of the intermediate Z in which the intramolecular ring closure reaction forms a fused silole ring is more than 70%.

According to one embodiment of the invention, in the synthesis method, the yield of the intermediate Z in which the intramolecular ring closure reaction forms a fused silole ring is greater than 80%.

Combined with other materials

The materials described herein for specific layers in an organic light emitting device may be used in combination with various other materials present in the device. Combinations of these materials are described in detail in U.S. patent application 2016/0359122A1, paragraphs 0132-0161, the entire contents of which are incorporated herein by reference. The materials described or mentioned therein are non-limiting examples of materials that may be used in combination with the compounds disclosed herein, and one skilled in the art can readily review the literature to identify other materials that may be used in combination.

Materials described herein as useful for specific layers in an organic light emitting device may be used in combination with a variety of other materials present in the device. For example, the compounds disclosed herein may be used in combination with a variety of light-emitting dopants, hosts, transport layers, barrier layers, implant layers, electrodes, and other layers that may be present. Combinations of these materials are described in detail in U.S. patent application Ser. No. 2015/0349273A1, paragraphs 0080-0101, the entire contents of which are incorporated herein by reference. The materials described or mentioned therein are non-limiting examples of materials that may be used in combination with the compounds disclosed herein, and one skilled in the art can readily review the literature to identify other materials that may be used in combination.

In the examples of material synthesis, all reactions were carried out under nitrogen protection, unless otherwise indicated. All reaction solvents were anhydrous and used as received from commercial sources. The synthetic products were subjected to structural confirmation and characterization testing using one or more equipment conventional in the art (including, but not limited to, bruker's nuclear magnetic resonance apparatus, shimadzu's liquid chromatograph, liquid chromatograph-mass spectrometer, gas chromatograph-mass spectrometer, differential scanning calorimeter, shanghai's optical technique fluorescence spectrophotometer, wuhan Koste's electrochemical workstation, anhui Bei Yi g sublimator, etc.), in a manner well known to those skilled in the art.

Example 1: synthesis of Compound 197.

Step 1: synthesis of intermediate 1-a.

To a 2L four-necked flask were added 500mL of Tetrahydrofuran (THF) and 300mL of water, 9-bromophenanthrene (100 g,0.389 mol), p-chlorophenylboronic acid (72.98 g,0.467 mol), potassium carbonate (80.62 g,0.583 mol) and Pd (PPh ₃)₄ (8.99 g,7.78 mmol) were successively added, the temperature was raised to 65℃under nitrogen protection, the reaction was kept at 65℃for 24 hours, the TLC was monitored until the reaction was completed, the temperature was lowered to room temperature, 10% aqueous cysteine solution and methyl t-butyl ether were added, the aqueous phase was separated, the organic phase was washed with 10% aqueous N-acetyl-L-cysteine solution, 5% aqueous sodium hydroxide solution and water, respectively, the solvent was removed by concentration to obtain crude product, the crude product was recrystallized with tetrahydrofuran and N-heptane, and the [ intermediate 1-a ] (white solid, 105.6g, yield 94%) was obtained by drying.

Step2: synthesis of intermediate 1-b.

To a 2000mL four-necked flask was added 500mL of 1, 4-dioxane, [ intermediate 1-a ] (100 g, 0.348 mol), pinacol biborate (131.9 g, 0.399 mol), palladium acetate (3.89 g,17.3 mmol), potassium acetate (101.96 g,1.04 mol) and 2-dicyclohexylphosphine-2 ',6' -dimethoxybiphenyl SPhos (14.22 g,34.6 mmol), the temperature was adjusted to 102℃and the reaction was kept at 102℃for 18 hours, thin Layer Chromatography (TLC) was monitored until the reaction was completed, the temperature was adjusted to 15℃and water was added for quenching the reaction, dichloromethane extraction was performed, the aqueous phase was once again extracted with ethyl acetate after separation, the organic phase was combined, the solvent was removed by concentration to obtain a crude product, which was recrystallized from dichloromethane and n-heptane, and after drying, the [ intermediate 1-b ] (white solid, 121.16g, yield 92%).

Step 3: [ Synthesis of intermediate 1-c ].

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To a 2000mL four-necked flask, 600mL tetrahydrofuran and 200mL water were added, followed by sequential addition of [ intermediate 1-b ] (100 g,0.263 mol), 2- (4-biphenyl) -4-chloro-6-phenyl-1, 3,5 triazine (90.41 g,0.263 mol), tetrakis triphenylphosphine palladium (15.19 g,13.1 mmol) and potassium carbonate (109.03 g,0.789 mol), adjustment of the temperature to 80℃and reaction at 80℃for 16 hours, TLC monitoring the reaction until the completion, adjustment of the temperature to 20℃and addition of water quenching reaction, addition of N-acetyl-L-cysteine stirring for 2 hours, filtration to obtain a crude product, recrystallization of the crude product with dichloromethane and N-heptane, and drying to obtain [ intermediate 1-c ] (white solid, 132.93g, yield 90%).

Step 4: synthesis of intermediate 1-d.

1200ML of methylene chloride and [ intermediate 1-c ] (120 g,0.214 mol) were added to a 2000mL four-necked flask, the temperature was adjusted to 10℃and bromine (37.56 g,0.235 mol) was added dropwise at about 10℃and after the addition was completed, the reaction was continued at 10℃for 2 hours, TLC was monitored until the completion, 10% potassium carbonate solution was added to adjust the pH to about 10, and 5% sodium thiosulfate aqueous solution was added to quench bromine. Dichloromethane was concentrated to dryness at low temperature, 300mL of n-heptane and 300mL of methyl tert-butyl ether were added dropwise, stirred at 10 ℃, filtered and dried to give crude product, which was purified by column chromatography to give [ intermediate 1-d ] (off-white solid, 109.48g, yield 80%).

Step 5: synthesis of intermediate 1-e.

To a 2000mL four-necked flask, 800mL tetrahydrofuran was added, intermediate 1-d (100 g,0.156 mol), the temperature was adjusted to-78℃and 2.5M n-butyllithium n-hexane solution (81.18 mL,0.203 mol) was added dropwise at about-78℃and reacted for half an hour at-78℃and diphenylchlorosilane (44.4 g,0.203 mol) was added dropwise at about-78℃and after the completion of the addition, the temperature was slowly raised to 20℃and reacted for 2 hours at 20℃and TLC was monitored until the completion of the reaction, saturated ammonium chloride solution was added to quench the reaction, water and ethyl acetate were added, the mixture was allowed to stand for delamination, the aqueous phase was extracted once with ethyl acetate, the organic phase was concentrated to a small volume and filtered to give a crude product, the crude product was added to a mixed solvent of 80mL dichloromethane and 800mL n-heptane and stirred for 2 hours and filtered, and dried to give intermediate 1-e (white solid, 97.56g, yield 84%).

Step 6: synthesis of Compound 197.

680ML of t-amyl alcohol, [ intermediate 1-e ] (90 g,0.121 mol), copper acetylacetonate (1.58 g,6 mmol) and t-butyl hydroperoxide (51.39 g,0.40mol,70% aqueous solution) were added to a 2000mL four-necked flask, the temperature was adjusted to 60 ℃, the reaction was maintained at 60 ℃ for 30 hours, TLC was monitored until the reaction was completed, the temperature was adjusted to 15 ℃, sodium bisulphite solution was added to quench the reaction, 25% aqueous ammonia was added, dichloromethane was added to extract the separated aqueous phase, once again dichloromethane extraction was performed on the aqueous phase, the organic phase was combined, the solvent was removed from the concentrated organic phase to give crude product, the crude product was recrystallized from dichloromethane and n-heptane, and dried to give compound 197 (off-white solid, 80.8g, yield 90%). The product was identified as the target product, molecular weight 741.3.

Example 2: synthesis of Compound 197

Step 1: synthesis of intermediate 2-a.

To a 2000mL four-necked flask, 680mL of t-amyl alcohol, [10- (4-chlorophenyl) phenanthrene-9-yl ] diphenylsilane (80 g,0.17 mol), copper acetylacetonate (2.22 g,8.49 mmol) and t-butylhydroperoxide (72.15 g,0.56mol,70% aqueous solution) were added, the temperature was adjusted to 60℃and kept at 60℃for 22 hours, TLC was monitored until the reaction was completed, the temperature was adjusted to 15℃and the sodium bisulfite solution was added to quench the reaction, 25% aqueous ammonia was added, dichloromethane was added to extract, after separation the aqueous phase was extracted once with dichloromethane, the organic phase was combined, the solvent was removed from the concentrated organic phase to give a crude product, which was recrystallized from dichloromethane and n-heptane and dried to give [ intermediate 2-a ] (off-white solid, 71.69g, yield 90%).

Step2: synthesis of intermediate 2-b.

To a 1000mL four-necked flask, 250mL of 1, 4-dioxane was added, stirring was started, and [ intermediate 2-a ] (50 g,0.107 mol), pinacol biborate (40.6 g,0.16 mol), palladium acetate (1.2 g,5.33 mmol), potassium acetate (31.38 g,0.32 mol) and SPhos (4.38 g,10.7 mmol) were sequentially added at room temperature, nitrogen was replaced, the temperature was adjusted to 102 ℃, the reaction was kept at 102℃for 18 hours, TLC was monitored until the reaction was completed, the temperature was adjusted to 20℃and water quenching reaction was added, N-acetyl-L-cysteine was added, stirring was performed for 2 hours, the crude product was obtained by filtration, recrystallized from methylene chloride and N-heptane, and dried to obtain [ intermediate 2-b ] (white solid, 54.98g, yield 92%).

Step 3: synthesis of Compound 197.

To a 2000mL four-necked flask, 600mL of tetrahydrofuran, 200mL of water, [ intermediate 2-b ] (50 g,89.2 mmol), 2- (4-biphenyl) -4-chloro-6-phenyl-1, 3,5 triazine (30.67 g,89.2 mmol), tetrakis triphenylphosphine palladium (5.15 g,4.46 mmol) and potassium carbonate (36.98 g,0.27 mol) were added, nitrogen was replaced, the temperature was adjusted to 80℃and the reaction was kept at 80℃for 16 hours, TLC was monitored until the reaction was completed, the temperature was adjusted to 20℃and water quenching reaction was added, N-acetyl-L-cysteine was added and stirred for 2 hours, and the crude product was obtained by filtration, recrystallized from methylene chloride and N-heptane, after which the compound 197 (white-like solid, 59.56g, yield 90%) was obtained by column chromatography. The product was identified as the target product, molecular weight 741.3.

Examples 3-9 illustrate examples of synthesis of intermediate 2-a using different reagents Q and solvents, which are each efficient for preparing intermediate 2-a; starting from intermediate 2-a, compound 197 can be readily obtained using the procedure of steps 2,3 of example 2, and is not repeated here.

Example 3

To a 25mL Schlenk tube was added 6.4mL t-amyl alcohol, [10- (4-chlorophenyl) phenanthr-9-yl ] diphenylsilane (0.80 g,1.70 mmol), cuprous oxide (0.05 g,0.34 mmol) and t-butylhydroperoxide (0.72 g,5.6mmol,70% aqueous solution), the temperature was adjusted to 60 ℃, TLC was monitored to stop the reaction, the temperature was adjusted to 15 ℃, sodium bisulfite solution was added to quench the reaction, 25% aqueous ammonia was added, dichloromethane extraction was added, after separation the aqueous phase was again extracted with dichloromethane, the organic phase was combined, the organic phase was concentrated to remove the solvent to give crude product, and the crude product was purified by column chromatography to give [ intermediate 2-a ] (off-white solid, 0.67g, yield 83.9%).

Example 4

To a 25mL Schlenk tube was added 6.4mL t-amyl alcohol, [10- (4-chlorophenyl) phenanthr-9-yl ] diphenylsilane (0.80 g,1.70 mmol), iron acetylacetonate (0.12 g,0.34 mmol) and t-butylhydroperoxide (0.72 g,5.6mmol,70% aqueous solution), the temperature was adjusted to 60 ℃, TLC was monitored until the reaction stopped, the temperature was adjusted to 15 ℃, sodium bisulfite solution was added to quench the reaction, 25% aqueous ammonia was added, dichloromethane extraction was added, after separation the aqueous phase was again extracted with dichloromethane, the organic phase was combined, the solvent was removed from the organic phase to give crude product, which was purified by column chromatography to give [ intermediate 2-a ] (off-white solid, 0.62g, yield 78%).

Example 5

To a 25mL Schlenk tube was added 6.4mL of t-amyl alcohol, [10- (4-chlorophenyl) phenanthr-9-yl ] diphenylsilane (0.80 g,1.70 mmol), copper (I) thiophene-2-carboxylate (0.06 g,0.34 mmol) and t-butylhydroperoxide (0.72 g,5.6mmol,70% in water), the temperature was adjusted to 60 ℃, TLC was monitored to stop the reaction, the temperature was adjusted to 15 ℃, sodium bisulfite solution was added to quench the reaction, 25% aqueous ammonia was added, dichloromethane extraction was added, the aqueous phase was separated and extracted once with dichloromethane, the organic phase was combined, the solvent was removed by concentrating to give crude product, which was purified by column chromatography to give [ intermediate 2-a ] (off-white solid, 0.71g, 89.4% yield).

Example 6

To a 25mL Schlenk tube was added 6.4mL t-amyl alcohol, [10- (4-chlorophenyl) phenanthr-9-yl ] diphenylsilane (0.80 g,1.70 mmol), copper acetate (0.07 g,0.34 mmol) and t-butyl hydroperoxide (0.72 g,5.6mmol,70% aqueous solution), the temperature was adjusted to 60 ℃, TLC was monitored to stop the reaction, the temperature was adjusted to 15 ℃, sodium bisulfite solution was added to quench the reaction, 25% aqueous ammonia was added, dichloromethane extraction was added, after separation the aqueous phase was again extracted with dichloromethane, the organic phases were combined, the organic phase was concentrated to remove the solvent to give the crude product, which was purified by column chromatography to give [ intermediate 2-a ] (off-white solid, 0.64g, 80% yield).

Example 7

To a 25mL Schlenk tube was added 6.4mL t-amyl alcohol, [10- (4-chlorophenyl) phenanthr-9-yl ] diphenylsilane (0.80 g,1.70 mmol), copper ethylacetoacetate (0.11 g,0.34 mmol) and t-butylhydroperoxide (0.72 g,5.6mmol,70% aqueous solution), the temperature was adjusted to 60 ℃, TLC was monitored to stop the reaction, the temperature was adjusted to 15 ℃, sodium bisulfite solution was added to quench the reaction, 25% aqueous ammonia was added, dichloromethane extraction was added, after separation the aqueous phase was again extracted with dichloromethane, the organic phase was combined, the solvent was removed from the concentrated organic phase to give crude product, which was purified by column chromatography to give [ intermediate 2-a ] (off-white solid, 0.74g, yield 92.5%).

Example 8

Into a 25mL Schlenk tube was added 6.4mL t-amyl alcohol, [10- (4-chlorophenyl) phenanthren-9-yl ] diphenylsilane (0.80 g,1.70 mmol), copper bis (2, 6-tetramethyl-3, 5-heptanedione) (0.15 g,0.34 mmol) and t-butyl hydroperoxide (0.72 g,5.6mmol,70% aqueous solution), the temperature was adjusted to 60 ℃, TLC was monitored until the reaction stopped, the temperature was adjusted to 15 ℃, sodium bisulfite solution was added to quench the reaction, 25% aqueous ammonia was added, dichloromethane extraction was added, the aqueous phase was again extracted with dichloromethane after separation, the organic phases were combined, the solvent was removed from the concentrated organic phase to give crude product, and the crude product was purified by column chromatography to give [ intermediate 2-a ] (off-white solid, 0.73g, 91.3%).

Example 9

To a 25mL Schlenk tube was added 6.4mL of t-amyl alcohol, [10- (4-chlorophenyl) phenanthr-9-yl ] diphenylsilane (0.80 g,1.70 mmol), cobalt chloride (0.04 g,0.34 mmol) and t-butylhydroperoxide (0.72 g,5.6mmol,70% aqueous solution), the temperature was adjusted to 60 ℃, TLC was monitored until the reaction stopped, the temperature was adjusted to 15 ℃, sodium bisulfite solution was added to quench the reaction, 25% aqueous ammonia was added, dichloromethane extraction was added, after separation the aqueous phase was again extracted with dichloromethane, the organic phase was combined, the organic phase was concentrated to remove the solvent to give crude product, and the crude product was purified by column chromatography to give [ intermediate 2-a ] (off-white solid, 0.71g, 88.7% yield).

To further demonstrate the excellent effect of the disclosed synthetic methods, comparative examples 1-5 were provided herein for the preparation of [ intermediate 2-a ] in different solvents under the action of tetrabutylammonium iodide (TBAI).

Comparative example 1

To a 25mL Schlenk tube was added 6.4mL of N, N-dimethylformamide DMF, [10- (4-chlorophenyl) phenanthren-9-yl ] diphenylsilane (0.80 g,1.70 mmol), tetrabutylammonium iodide (0.03 g,0.08 mmol) and t-butylhydroperoxide (0.72 g,5.6mmol,70% in water), the temperature was adjusted to 90℃and continued for 24h, and TLC did not monitor for [ intermediate 2-a ].

Comparative example 2

Into a 25mL Schlenk tube were added 6.4mL of xylene, [10- (4-chlorophenyl) phenanthr-9-yl ] diphenylsilane (0.80 g,1.70 mmol), tetrabutylammonium iodide (0.03 g,0.08 mmol) and t-butylhydroperoxide (0.72 g,5.6mmol,70% aqueous solution), the temperature was adjusted to 90℃until the reaction stopped, TLC was monitored, the temperature was adjusted to 15℃and the reaction was quenched by addition of sodium bisulfite solution, 25% aqueous ammonia was added, dichloromethane extraction was performed, after separation the aqueous phase was once extracted with dichloromethane, the organic phase was combined, the solvent was removed from the organic phase to give a crude product, which was purified by column chromatography to give [ intermediate 2-a ] (off-white solid, 0.15g, yield 18.8%).

Comparative example 3

Benzene 6.4mL, [10- (4-chlorophenyl) phenanthren-9-yl ] diphenylsilane (0.80 g,1.70 mmol), tetrabutylammonium iodide (0.03 g,0.08 mmol) and tert-butylhydroperoxide (0.72 g,5.6mmol,70% aqueous solution) were added to a 25mL Schlenk tube, the temperature was adjusted to 90℃until the reaction stopped, TLC was monitored, the temperature was adjusted to 15℃and quenched by the addition of sodium bisulfite solution, 25% aqueous ammonia was added, dichloromethane extraction was performed, after separation the aqueous phase was again extracted with dichloromethane, the organic phase was combined, the solvent was removed from the organic phase to give crude product, and the crude product was purified by column chromatography to give [ intermediate 2-a ] (off-white solid, 0.46g, yield 57.8%).

Comparative example 4

Into a 25mL Schlenk tube were added 6.4mL of tetrahydrofuran, [10- (4-chlorophenyl) phenanthryl-9-yl ] diphenylsilane (0.80 g,1.70 mmol), tetrabutylammonium iodide (0.03 g,0.08 mmol) and tert-butylhydroperoxide (0.72 g,5.6mmol,70% aqueous solution), the temperature was adjusted to 90℃until the reaction stopped, TLC was monitored, the temperature was adjusted to 15℃and the reaction was quenched by adding sodium bisulfite solution, 25% aqueous ammonia was added, dichloromethane was added to extract, after separation the aqueous phase was once extracted with dichloromethane, the organic phase was combined, the solvent was removed from the concentrated organic phase to give a crude product, which was purified by column chromatography to give [ intermediate 2-a ] (off-white solid, 0.06g, yield 8%).

Comparative example 5

To a 25mL Schlenk tube was added 6.4mL t-butanol, [10- (4-chlorophenyl) phenanthryl-9-yl ] diphenylsilane (0.80 g,1.70 mmol), tetrabutylammonium iodide (0.03 g,0.08 mmol) and t-butylhydroperoxide (0.72 g,5.6mmol,70% aqueous solution), the temperature was adjusted to 60℃until the reaction stopped, TLC was monitored, the temperature was adjusted to 15℃and the reaction was quenched by addition of sodium bisulfite solution, 25% aqueous ammonia was added, dichloromethane extraction was performed, after separation the aqueous phase was once extracted with dichloromethane, the organic phase was combined, the solvent was removed from the concentrated organic phase to give crude product, which was purified by column chromatography to give [ intermediate 2-a ] (off-white solid, 0.51g, yield 62.2%).

Discussion:

In the synthesis method provided by the invention, the key steps are the steps of forming a fused silole ring by intramolecular ring closure reaction of the intermediate Z, for example:

Examples 2 to 9 and comparative examples 1 to 5 each involved a reaction for preparing intermediate 2-a by starting with [10- (4-chlorophenyl) phenanthren-9-yl ] diphenylsilane in the presence of different reagents M (oxidizing agent) and Q (initiator) in different solvents, except that example 1 was an intramolecular ring-closure reaction using intermediate 1-e. For better comparative examples of the reaction, the data of the reactions related to examples 2 to 9 and comparative examples 1 to 5 are summarized and shown in Table 2 below. Since the ring-closing reaction conditions and yields of example 1, step 6 are the same as example 2, they are not repeated in table 2.

TABLE 2 data for the reactions of examples 2-9 and comparative examples 1-5

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Discussion:

In an alcohol solvent, in the presence of the reagent M, the reagent Q of the metal oxide and the Lewis acid selected by the invention can well initiate the reaction at a greatly reduced reaction temperature (60 ℃), and can efficiently complete the reaction: the yields of examples 1-9 were all above 78%, while the yields of comparative examples 1-5 were only 62.2% at maximum, with the yields of examples being at least 25% higher than that of comparative examples; and the yield of most of the embodiments is above 80%, the high yield is beneficial to simplifying post-treatment and purification procedures, facilitating the easier acquisition of high-purity target products, and reducing the cost. Therefore, the synthesis method provided by the invention can realize the preparation of the target product in a scale of more than 50 g with greatly improved yield under a lower temperature condition.

In comparative examples 1 to 4, however, the same or similar non-alcoholic solvents (such as DMF, xylene, benzene, tetrahydrofuran, etc.) as the prior art were used, and even at a greatly increased reaction temperature (90 ℃) the reaction was still well initiated using TBAI which was considered to be the best in the prior art, and no satisfactory yield (up to 57.8%) could be obtained, indicating that the synthetic method disclosed in the present invention has excellent effects of low reaction temperature, mild conditions and low cost due to the use of alcoholic solvents and the selection of more suitable reagent Q as an initiator, and represents a great application prospect of the synthetic method in large-scale industrial synthesis.

The intramolecular oxidation cyclization reaction of the intermediate Z is a free radical reaction, and generally, the nonpolar solvent is more favorable for the free radical reaction, but as can be seen from comparison of examples and comparative examples, in the nonpolar solvent such as benzene, the intramolecular cyclization reaction yield of the intermediate Z is very low, while in the method of the invention, the unexpectedly large improvement of the reaction yield is realized by using the alcohol solvent, and the great advantage of the method of the invention is further proved.

Further, although it is thought that DIRK LEIFERT in org.lett.2015, 17, 386-389 et al has an effect of promoting the reaction by iodide ions, it is clear from the comparison of examples 1 to 9 and comparative examples 1 to 5 that the use of a reagent (TBAI) containing iodide ions does not allow the reaction to be carried out in a higher yield, whereas the present application provides an unexpected excellent effect in that the use of reagent Q containing no iodide ions as an initiator allows the reaction to be carried out in a greatly improved yield. In addition, it can be seen from comparison of comparative examples 5 and 3 that the alcohol solvent can achieve an improvement of approximately 10% in reaction yield under the condition of greatly reduced temperature, whereas examples 1 to 9 using the alcohol solvent and the reagent Q can achieve a further great improvement in reaction yield, further demonstrating the unexpected excellent effect brought about by the combined action of the alcohol solvent and the reagent Q in the method disclosed by the present application, and again demonstrating the great advantage of the method of the present application.

In addition, the synthesis method of the invention also avoids the use of noble metals such as Rh and the like, thereby further saving the cost.

Those skilled in the art will recognize that the above preparation method is only an illustrative example, and that those skilled in the art can modify it to obtain other compound structures of the present invention.

The applicant states that the process of the invention is illustrated by the above examples, but the invention is not limited to, i.e. does not mean that the invention must be carried out in dependence on the above process steps. It should be apparent to those skilled in the art that any modification of the present invention, equivalent substitution of selected raw materials, addition of auxiliary components, selection of specific modes, etc. fall within the scope of the present invention and the scope of disclosure.

Claims

1. A method for synthesizing a fused ring compound containing a silage five-membered ring structure, characterized in that the fused ring compound has a structure as shown in formula 1:

A has a structure as shown in formula 2:

The synthesis method comprises the following steps:

the intermediate Z has a structure as shown in formula 2-1 or formula 2-2:

in the formula 2, the formula 2-1 and the formula 2-2,

T ₁ to T ₁₂ are each independently selected from C, CR _T or N;

the reagent M is peroxide;

The reagent Q is selected from a transition metal oxide or a transition metal-containing Lewis acid, and the reagent Q does not contain iodide ions.

2. The synthesis method according to claim 1, wherein when the intermediate Z has a structure represented by formula 2-1, the intermediate Z undergoes an intramolecular ring closure reaction to obtain an intermediate a ', and the synthesis method further comprises a step of reacting the intermediate a' with n intermediates containing L-B structures to obtain the condensed-cyclic compound.

3. The synthetic method of claim 2 wherein the step of reacting said intermediate a' with n intermediates comprising L-B structures to obtain said fused ring compound comprises a transition metal catalyst catalyzed cross-coupling step.

4. The synthetic method according to claim 1, wherein when the intermediate Z has a structure represented by formula 2-2, the intermediate Z undergoes an intramolecular ring-closing reaction to give the condensed-cyclic compound.

5. The synthetic method according to claim 4, wherein when the intermediate Z has a structure represented by formula 2-2, the intermediate Z is obtained by reacting an intermediate having a structure represented by formula 2-1 with n intermediates containing L-B structures, and the step of reacting an intermediate having a structure represented by formula 2-1 with n intermediates containing L-B structures comprises a step of cross-coupling catalyzed by a transition metal catalyst.

6. The synthetic method of claim 1 wherein R ₁、R₂ is selected identically or differently on each occurrence from substituted or unsubstituted aryl groups having 6 to 30 carbon atoms, substituted or unsubstituted heteroaryl groups having 3 to 30 carbon atoms.

7. The synthesis method according to claim 1, wherein a has a structure shown in formula 3:

Wherein T ₁ to T ₂₂ are each independently selected from C, CR _T or N;

Adjacent substituents R _T can optionally be linked to form a ring.

8. The synthetic method of claim 1 or 7 wherein L is selected from a single bond, a substituted or unsubstituted arylene group having 6 to 20 carbon atoms, a substituted or unsubstituted heteroarylene group having 3 to 20 carbon atoms, or a combination thereof.

9. The synthetic method of claim 8 wherein L is selected from the group consisting of a single bond and formulas 4 to 28:

Wherein the dotted line represents the attachment site of the group;

10. The synthetic method of claim 1 wherein B is selected from the group consisting of formulas 29 to 33:

Wherein the dotted line represents the attachment site of the group;

X ₁ to X ₆ are each independently selected from CR _X, C or N;

y ₁ is selected from O, S or NR _X';

11. The synthetic method of claim 1 wherein the fused ring compound has a structure as shown in formula 1:

Wherein n is 1 or 2;

The a is selected from the group consisting of A1 to a 50:

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each L is independently selected from the group consisting of L0 to L58:

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12. The method of claim 1, wherein the reagent M is t-butyl hydroperoxide.

13. The synthesis according to claim 1 or 12, wherein the amount of substance of reagent M is 3-10 times the amount of substance of intermediate Z.

14. The synthesis according to claim 1 or 12, wherein the amount of substance of reagent M is 3-5 times the amount of substance of intermediate Z.

15. The synthetic method according to claim 1, wherein the reagent Q is selected from copper oxide, copper-containing lewis acid, iron-containing lewis acid or cobalt-containing lewis acid.

16. The synthesis according to claim 1, wherein the reagent Q is selected from copper (II) acetylacetonate, iron acetylacetonate, cobalt dichloride, copper cyanide, copper (I) thiophene-2-carboxylate, copper acetate, copper trifluoromethane sulfonate, copper (II) acetoacetate, copper oxide or copper bis (2, 6-tetramethyl-3, 5-heptanedione) oxide.

17. The synthesis according to claim 1, wherein the amount of substance of reagent Q is 1% -100% of the amount of substance of intermediate Z.

18. The method according to claim 1, wherein the alcoholic solvent is selected from any one or a combination of at least two of methanol, ethanol, n-propanol, isopropanol, n-butanol, t-amyl alcohol, 2-methoxyethanol, and 2-ethoxyethanol.

19. The synthetic method according to claim 1, wherein the intramolecular cyclization reaction has a reaction temperature of room temperature to 100 ℃.

20. The synthetic method according to claim 1, wherein the intermediate Z undergoes intramolecular ring closure reaction to form a fused silole ring in a yield of greater than 60%.