CN117959615A - Flexible light guide structure, flexible wearable photodynamic therapeutic apparatus and use method thereof - Google Patents
Flexible light guide structure, flexible wearable photodynamic therapeutic apparatus and use method thereof Download PDFInfo
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- 238000000034 method Methods 0.000 title claims abstract description 17
- 238000005253 cladding Methods 0.000 claims abstract description 35
- 230000005540 biological transmission Effects 0.000 claims abstract description 21
- 238000002428 photodynamic therapy Methods 0.000 claims description 19
- 238000009792 diffusion process Methods 0.000 claims description 18
- 238000007493 shaping process Methods 0.000 claims description 9
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 230000008878 coupling Effects 0.000 abstract description 6
- 238000010168 coupling process Methods 0.000 abstract description 6
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- 238000001126 phototherapy Methods 0.000 abstract description 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0616—Skin treatment other than tanning
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0632—Constructional aspects of the apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0645—Applicators worn by the patient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0664—Details
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- Life Sciences & Earth Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
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- Radiology & Medical Imaging (AREA)
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Abstract
The application relates to a flexible light guide structure, a flexible wearable photodynamic therapeutic apparatus and a use method thereof, which relate to the technical field of external phototherapy and comprise the following steps: a light guide core and a light shielding cladding; the light guide core comprises a first light guide section and a second light guide section connected with the first light guide section, one end of the first light guide section, which is away from the second light guide section, is used for coupling incident therapeutic light, and the caliber of the second light guide section is reduced towards the direction away from the first light guide section; the shading cladding is coated on the periphery of the light guide core, and the shading cladding defines a light transmission area, and the light transmission area is used for attaching skin and emitting the therapeutic light. According to the application, on one hand, through the design that the caliber of the second light guide section is reduced in the direction away from the first light guide section, the total reflection of the therapeutic light is destroyed, and meanwhile, the light shielding cladding defines the light transmission area, so that the therapeutic light only exits from the light transmission area, and the utilization rate of the therapeutic light can be greatly improved.
Description
Technical Field
The application relates to the technical field of external phototherapy, in particular to a flexible light guide structure, a flexible wearable photodynamic therapeutic apparatus and a use method thereof.
Background
At present, photodynamic therapy uses a photosensitizing agent with specific wavelength to generate singlet oxygen, and kills pathological tissue cells by utilizing the toxic action of the singlet oxygen, thereby achieving the purpose of treating diseases.
In the related art, a dispersing agent is arranged in a plurality of optical fibers so as to enable therapeutic light to be transmitted out of the side surfaces of the optical fibers, thereby achieving the purpose of irradiating and treating the skin of a patient.
However, in this way, part of the light is transmitted along the optical fiber in a total reflection way, and part of the light cannot be transmitted from the side face of the optical fiber, while the other part of the light is transmitted from the periphery of the side face of the optical fiber, and the skin actually required to be irradiated by the user only has one side of the optical fiber, so that the light utilization rate is very low.
Disclosure of Invention
The application aims to at least solve the technical problem of low light utilization rate in the prior art. Therefore, the application provides a flexible light guide structure, a flexible wearable photodynamic therapeutic apparatus and a use method thereof.
In a first aspect, the present application provides a flexible light guiding structure comprising: a light guide core and a light shielding cladding; the light guide core comprises a first light guide section and a second light guide section connected with the first light guide section, one end of the first light guide section, which is away from the second light guide section, is used for coupling incident therapeutic light, and the caliber of the second light guide section is reduced towards the direction away from the first light guide section; the shading cladding is coated on the periphery of the light guide core, and the shading cladding defines a light transmission area, and the light transmission area is used for attaching skin and emitting the therapeutic light.
By adopting the technical scheme, on one hand, the total reflection of the therapeutic light is destroyed by the design that the caliber of the second light guide section is reduced towards the direction away from the first light guide section, and meanwhile, the light shielding cladding defines a light transmission area, so that the therapeutic light only exits from the light transmission area, and the utilization rate of the therapeutic light can be greatly improved; on the other hand, the flexible light guide structure adopts an integrated design, so that the whole structure is simplified and simultaneously the flexible light guide structure can be better adapted to human skin.
According to one embodiment of the application, the second light guide section is provided with a reflecting film at least partially opposite to the light transmission area.
By adopting the technical scheme, the treatment light is reflected by the reflecting film, so that the treatment light can be emitted from the light-transmitting area more easily.
According to one embodiment of the application, the light-transmitting area is hollowed out, the light-transmitting area is provided with an elastic dispersion layer, a first surface of the elastic dispersion layer is connected with the second light guide section, and a second surface of the elastic dispersion layer adjacent to the first surface is connected with the shading cladding.
By adopting the technical scheme, when the elastic diffusion layer at the light-transmitting area is attached to the target skin, the part of the elastic diffusion layer corresponding to the scar or the salient point of the target skin can deform, so that the body feeling of a user is good.
In addition, the elastic dispersion layer can scatter the therapeutic light emitted from the light-transmitting area, so that the therapeutic light is emitted more uniformly, and the coverage of the therapeutic light on the target skin is improved.
Moreover, from the perspective of the manufacturing process, the elastic dispersion layer can be used as an independent layered component to be connected to the light-transmitting area, so that on one hand, compared with the case that dispersion particles are arranged in the second light guide section, the customization is stronger, for example, the elastic dispersion layer can be customized according to the design requirement, so that the number and distribution of the dispersion particles in the elastic dispersion layer are more reasonable, and a better scattering effect is realized; on the other hand, the whole manufacturing flow is simplified, and the manufacturing steps and the complexity are reduced.
According to one embodiment of the application, one side of the first light guide section is coplanar with one side of the second light guide section, and the other side of the second light guide section is inclined close to one side of the second light guide section.
By adopting the technical scheme, the other side of the second light guide section is inclined to be close to one side of the second light guide section, so that the total reflection transmission of therapeutic light in the second light guide section can be broken.
In addition, one side of the first light guide section is coplanar with one side of the second light guide section, so that the shading cladding of one side of the first light guide section and one side of the second light guide section are also coplanar, the flexible light guide structure is conveniently bound around a limb of a user by a user, and a stable position is ensured in the use process.
According to one embodiment of the application, a first magic tape is arranged on one side of the shading cladding opposite to the second light guide section, a second magic tape is arranged on the other side of the shading cladding opposite to the first light guide section, and the first magic tape is suitable for being adhered to the second magic tape.
In a second aspect, the present application provides a flexible wearable photodynamic therapy device comprising: the therapeutic apparatus body, a plurality of therapeutic light sources, the plastic lens group and the flexible light guide structure in any embodiment;
the treatment light sources are arranged side by side and are used for emitting treatment light with specific wave bands;
the therapeutic apparatus body is electrically connected with a plurality of therapeutic light sources and can selectively control the output power of each therapeutic light source;
the shaping lens group is arranged in the outgoing direction of the therapeutic light and is used for enabling the therapeutic light to be incident into the flexible light guide structure.
By adopting the technical scheme, the output power of the therapeutic light source corresponding to the non-target skin is selectively controlled to be adjusted to 0 through the therapeutic apparatus body, and the output power of the therapeutic light source corresponding to the target skin is controlled to reach the preset power, so that the therapeutic light emitted from the light-transmitting area of the flexible light guide structure is concentrated on the target skin.
By controlling the output power of the treatment light source, the accurate treatment of the target skin can be realized, and the interference to the non-target skin is reduced; the treatment process is more flexible, and the output power of the treatment light source corresponding to the target skin can be adjusted according to the needs of patients and the characteristics of the target skin area of different lesions.
According to one embodiment of the present application, the light-transmitting region has a plurality of positions, the light-shielding cladding between every two adjacent positions of the light-transmitting region is defined as a light-shielding region, the light-shielding region is opaque, and the therapeutic apparatus body is configured to control the output power of the therapeutic light source corresponding to the light-shielding region to be 0.
By adopting the technical scheme, in the process of transmitting the therapeutic light to the light-transmitting area of the flexible light guide structure and emitting the therapeutic light from the light-transmitting area of the flexible light guide structure, the therapeutic light can be influenced by other factors (such as scattering and the like), so that the therapeutic light corresponding to the target skin can be less irradiated to the non-target skin.
In this embodiment, the light shielding region is provided, so that the therapeutic light is emitted only from the light transmitting region, and the therapeutic light is prevented from being irradiated to the non-target skin, thereby avoiding adverse effects on the non-target skin.
According to one embodiment of the present application, the shaping lens group includes: a slow axis collimating lens and a fast axis focusing lens;
the slow axis collimating lens and the fast axis focusing lens are sequentially arranged along the emergent direction of the therapeutic light;
The slow axis collimating lens is used for collimating the therapeutic light in a slow axis mode, and the fast axis focusing lens is used for focusing the therapeutic light in a fast axis mode so that the therapeutic light is incident into the flexible light guide structure.
Through adopting above-mentioned technical scheme, design like this can guarantee that this laser beam gets into and transmits along specific direction in flexible light guide structure's first leaded light section effectively, and energy loss and light beam diffusion are reduced as far as possible, make more stable and concentrated during its transmission, improve the treatment of flexible wearable photodynamic therapy appearance.
According to one embodiment of the application, the therapeutic light is a laser beam;
the light spot size formed by the laser beam passing through the fast axis focusing lens is smaller than the thickness of the first light guide section; and/or the divergence angle of the laser beam is smaller than the acceptance angle of the first light guide section.
In a third aspect, the present application also provides a method of using a flexible wearable photodynamic therapy device, comprising:
binding the flexible light guide structure to the limb, wherein the light transmission area of the flexible light guide structure is opposite to the skin, and the skin comprises target skin and non-target skin;
and controlling the output power of the plurality of therapeutic light sources so that the output power of the therapeutic light source corresponding to the non-target skin is 0.
In summary, the present application includes at least one of the following beneficial technical effects: on one hand, the total reflection of the therapeutic light is destroyed by the design that the caliber of the second light guide section is reduced in the direction away from the first light guide section, and meanwhile, the light shielding cladding defines a light transmission area, so that the therapeutic light only exits from the light transmission area, and the utilization rate of the therapeutic light can be greatly improved; on the other hand, the flexible light guide structure adopts an integrated design, so that the whole structure is simplified and simultaneously the flexible light guide structure can be better adapted to human skin.
Drawings
FIG. 1 is a schematic diagram of a flexible light guiding structure according to an embodiment of the present application;
FIG. 2 is a second schematic structural diagram of a flexible light guiding structure according to an embodiment of the present application;
FIG. 3 is a third schematic structural view of a flexible light guiding structure according to an embodiment of the present application;
FIG. 4 is a schematic diagram of a flexible light guiding structure according to an embodiment of the present application;
FIG. 5 is a schematic diagram of a flexible wearable photodynamic therapy device according to an embodiment of the present application;
FIG. 6 is a second schematic diagram of a flexible wearable photodynamic therapy device according to an embodiment of the present application;
FIG. 7 is a schematic diagram of a part of a flexible light guiding structure according to an embodiment of the present application;
FIG. 8 is a schematic diagram of a second partial structure of a flexible light guiding structure according to an embodiment of the present application;
Fig. 9 is a schematic flow chart of steps of a method for using the flexible wearable photodynamic therapy device according to the embodiment of the application.
Reference numerals:
10. A flexible light guiding structure;
100. a light guide core; 110. a first light guide section; 120. a second light guide section;
200. A light shielding cladding; 210. a light-transmitting region;
310. A reflective film; 320. an elastic dispersion layer;
410. a first magic tape; 420. the second magic tape;
20. A therapeutic light source; 30. shaping lens group; 31. a slow axis collimating lens; 32. a fast axis focusing lens; a. therapeutic light.
Detailed Description
Embodiments of the present application are described in detail below, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the drawings are illustrative only and are not to be construed as limiting the application.
A flexible light guide structure 10, a flexible wearable photodynamic therapy device, and a method of using the flexible wearable photodynamic therapy device according to an embodiment of the application are described below with reference to fig. 1-9.
As shown in fig. 1 and 2, the flexible light guiding structure 10 includes: a light guide core 100 and a light shielding clad 200.
The flexible light guiding structure 10 is capable of bending at an angle, the radius of which is mainly related to the thickness of the light guiding core 100, and the larger the thickness of the light guiding core 100, the larger the radius of which is bent.
The light guide core 100 includes a first light guide section 110 and a second light guide section 120 connected to the first light guide section 110.
The end of the first light guiding section 110 facing away from the second light guiding section 120 is used for coupling incidence of therapeutic light a, and the therapeutic light a may be laser light with a specific wavelength or monochromatic light with a specific wavelength emitted by an LED light source, which is not limited in this embodiment.
The first light guide section 110 is used for total reflection transmission of the therapeutic light a.
The second light guiding section 120 may be integrally formed with the first light guiding section 110, and the aperture of the second light guiding section 120 decreases in a direction away from the first light guiding section 110.
In practical implementation, the first light guide section 110 and the second light guide section 120 of the light guide core 100 may be made of soft transparent plastic, such as polystyrene, polymethyl methacrylate, and the like.
The light shielding cladding 200 is coated on the periphery of the light guide core 100, and the refractive index of the light shielding cladding 200 should be smaller than that of the light guide core 100, so that the therapeutic light a satisfies the total reflection condition when transmitted by the first light guide section 110.
The light shielding layer 200 defines a light transmitting area 210, and the light transmitting area 210 is used for attaching to skin and emitting therapeutic light a, wherein the therapeutic light a can be a linear light source or a surface light source.
In the related art, a dispersing agent is arranged in a plurality of optical fibers so as to enable therapeutic light a to be transmitted out of the side surfaces of the optical fibers, thereby achieving the purpose of irradiating and treating the skin of a patient.
However, in this way, part of the light is transmitted along the optical fiber in a total reflection way, and part of the light cannot be transmitted from the side face of the optical fiber, while the other part of the light is transmitted from the periphery of the side face of the optical fiber, and the skin actually required to be irradiated by the user only has one side of the optical fiber, so that the light utilization rate is very low.
In the above embodiment of the present application, the design that the aperture of the second light guiding section 120 decreases in the direction away from the first light guiding section 110 can destroy the total reflection of the therapeutic light a, and the light shielding cladding 200 defines the light transmitting area 210, so that when the flexible light guiding structure 10 is bound on the limb of the user, and the target skin to be treated of the user corresponds to the light transmitting area 210 of the flexible light guiding structure 10, the therapeutic light a only exits from the light transmitting area 210, which can greatly improve the utilization rate of the therapeutic light a.
In addition, the flexible light guide structure 10 of the present application adopts an integrated design, so that the whole structure is simplified, and the flexible light guide structure can better adapt to the curved surface of the skin of the limb of the user, and can be better attached to the skin, for example, the flexible light guide structure 10 can be worn on the curved surface of the skin such as the leg, the arm, etc.
In summary, according to the flexible light guiding structure 10 provided by the present application, on one hand, the total reflection of the therapeutic light a is destroyed by the design that the aperture of the second light guiding section 120 is reduced in the direction away from the first light guiding section 110, and meanwhile, the light shielding cladding 200 defines the light transmitting region 210, so that the therapeutic light a only exits from the light transmitting region 210, which can greatly improve the utilization rate of the therapeutic light a; on the other hand, the flexible light guide structure 10 adopts an integrated design, so that the whole structure is simplified and the flexible light guide structure can be better adapted to human skin.
As shown in fig. 3 and 4, in some embodiments, one side of the first light guide section 110 is coplanar with one side of the second light guide section 120, and the other side of the second light guide section 120 is inclined closer to one side of the second light guide section 120.
In this embodiment, the other side of the second light guiding section 120 is inclined to approach to one side of the second light guiding section 120, so that the total reflection transmission of the therapeutic light a in the second light guiding section 120 can be broken.
In addition, one side of the first light guiding section 110 is coplanar with one side of the second light guiding section 120, so that the light shielding cladding 200 of one side of the first light guiding section 110 and one side of the second light guiding section 120 is also coplanar, which is convenient for the user to tie the flexible light guiding structure 10 around the limb of the user, and ensures that a stable position is maintained during use.
Specifically, a first magic tape 410 is disposed on one side of the light shielding cladding 200 opposite to the second light guiding section 120, a second magic tape 420 is disposed on the other side of the light shielding cladding 200 opposite to the first light guiding section 110, and the first magic tape 410 is adapted to adhere to the second magic tape 420.
As shown in fig. 3 and 4, in actual implementation, the second light guiding section 120 is provided with a reflective film 310 at least partially facing the light transmitting region 210. The reflective film 310 may be a metal film, a dielectric film, or some other possible reflective coating, and the present embodiment is not limited thereto.
Thus, the therapeutic light a is reflected by the reflective film 310, and can be more easily emitted from the light-transmitting region 210.
As shown in fig. 3 and fig. 4, in some embodiments, the light-transmitting area 210 is hollowed out, the light-transmitting area 210 is provided with an elastic diffusion layer 320, a first surface of the elastic diffusion layer 320 is connected to the second light guiding section 120, and a second surface of the elastic diffusion layer 320 adjacent to the first surface is connected to the light-shielding cladding 200.
It should be noted that the target skin to be treated may not be a plane, such as a scar or a bump on the target skin.
In this embodiment, when the elastic diffusion layer 320 at the light-transmitting area 210 is attached to the target skin, the portion of the elastic diffusion layer 320 corresponding to the scar or bump of the target skin is deformed, so that the body feeling of the user is good.
In addition, the elastic diffusion layer 320 can scatter the therapeutic light a emitted from the light-transmitting region 210 to make the emission more uniform, which improves the coverage of the therapeutic light a on the target skin.
Moreover, from the perspective of the manufacturing process, the elastic dispersion layer 320 can be connected to the light-transmitting region 210 as an independent layered component, so that on one hand, compared with the case that dispersion particles are arranged in the second light-guiding section 120, the customization is stronger, for example, the elastic dispersion layer 320 can be customized according to the design requirement, so that the number and distribution of the dispersion particles in the elastic dispersion layer 320 are more reasonable, and a better scattering effect is realized; on the other hand, the whole manufacturing flow is simplified, and the manufacturing steps and the complexity are reduced.
As shown in fig. 5 and 6, the present application also provides a flexible wearable photodynamic therapy device comprising: the therapeutic apparatus body, the plurality of therapeutic light sources 20, the plastic lens group 30, and the flexible light guiding structure 10 as described in any of the embodiments above.
The plurality of therapeutic light sources 20 are arranged side by side and are used for emitting therapeutic light a of a specific wavelength band, and the therapeutic light sources 20 include laser light sources or LED light sources, which is not limited in this embodiment.
The wave band of the therapeutic light a can be 630-700 nanometers, and can be used for treating ultra-shallow epidermis lesions such as non-melanoma skin lesions; the wavelength band of the therapeutic light a can be 400-500 nanometers, and the therapeutic light can have bactericidal effect on some superficial infectious lesions such as acne through the oxide generated by the photosensitizer; the wave band of the therapeutic light a can be selected from 810-830 nanometers, and can be used for treating diseases such as rheumatoid arthritis and the like.
Of course, other wavelength bands of therapeutic light a may be selected, and this embodiment is not limited.
The therapeutic apparatus body is electrically connected to the plurality of therapeutic light sources 20, and can selectively control the output power of each therapeutic light source 20.
The shaping lens set 30 is disposed in the outgoing direction of the therapeutic light a, and is used for coupling the therapeutic light a into the flexible light guiding structure 10.
It should be noted that the flexible light guiding structure 10 may be tied to a limb of a user, and the skin of the limb includes a target skin requiring treatment and a non-target skin not requiring treatment, and the target skin may be multiple locations and spaced apart from the non-target skin.
The related art firstly uses a black adhesive tape or a shielding cloth to shield the non-target skin, and then the plurality of therapeutic light sources 20 emit therapeutic light a, and the therapeutic light a irradiates the target skin after being emitted from the light-transmitting area 210 of the flexible light-guiding structure 10.
In the above embodiment of the present application, the therapeutic light a emitted from the light-transmitting region 210 of the flexible light-guiding structure 10 is concentrated on the target skin by selectively controlling the output power of the therapeutic light source 20 corresponding to the non-target skin to be adjusted to 0 and controlling the output power of the therapeutic light source 20 corresponding to the target skin to reach the preset power.
By controlling the output power of the therapeutic light source 20, the accurate treatment of the target skin can be realized, and the interference to the non-target skin is reduced; the treatment process is also more flexible, and the output power of the treatment light source 20 corresponding to the target skin can be adjusted according to the needs of patients and the characteristics of the target skin area of different lesions.
As shown in fig. 7, in some embodiments, the light-transmitting region 210 has a plurality of light-shielding cladding 200 between every two adjacent light-transmitting regions 210 is defined as a light-shielding region, the light-shielding region is opaque, and the therapeutic apparatus body is configured to control the output power of the therapeutic light source 20 corresponding to the light-shielding region to be 0.
In this embodiment, the therapeutic light a may be affected by other factors (such as scattering, etc.) during the transmission of the therapeutic light a within the flexible light guiding structure 10 to the light transmitting region 210 of the flexible light guiding structure 10, so that a small portion of the therapeutic light a corresponding to the target skin is also irradiated to the non-target skin.
In this embodiment, the light shielding region is provided, so that the therapeutic light a is emitted only from the light transmitting region 210, and is prevented from being irradiated onto the non-target skin, thereby avoiding adverse effects on the non-target skin.
Of course, the light-transmitting area 210 is only one place, and a manner of not defining the light-shielding area should be allowed.
As shown in fig. 5 and 6, in some embodiments, the shaping lens group 30 includes: a slow axis collimator lens 31 and a fast axis focusing lens 32.
The slow axis collimator lens 31 and the fast axis focusing lens 32 are sequentially disposed along the outgoing direction of the therapeutic light a.
Wherein the slow axis collimating lens 31 is used for collimating the therapeutic light a in the slow axis, and the fast axis focusing lens 32 is used for focusing the therapeutic light a in the fast axis, so that the therapeutic light a is coupled into the flexible light guiding structure 10.
In particular, the treatment light source 20 may be selected to be a laser light source that emits a Bar (Bar) shaped laser beam.
The slow axis collimating lens 31 may be a micro lens array for collimating the laser beam in the slow axis.
The fast axis focusing lens 32 may be a cylindrical lens for focusing the laser beam exiting the slow axis collimating lens 31 in the fast axis such that the laser beam is coupled into the first light guiding section 110 of the flexible light guiding structure 10.
The design can ensure that the laser beam effectively enters and is transmitted along a specific direction in the first light guide section 110 of the flexible light guide structure 10, so that energy loss and light beam diffusion are reduced as much as possible, the transmission is more stable and concentrated, and the treatment effect of the flexible wearable photodynamic therapeutic apparatus is improved.
In actual implementation, the spot size of the laser beam formed by the fast axis focusing lens 32 is smaller than the thickness of the first light guide section 110; and/or the divergence angle of the laser beam is smaller than the acceptance angle of the first light guide section 110.
The above-described embodiments of the present application will be specifically described below from two different implementation angles, respectively.
1. As shown in fig. 1-4, the flexible light guiding structure 10 includes: a light guide core 100 and a light shielding clad 200.
The light guide core 100 includes a first light guide section 110 and a second light guide section 120 connected to the first light guide section 110, wherein one end of the first light guide section 110 facing away from the second light guide section 120 is used for treating light a coupling incidence, the caliber of the second light guide section 120 decreases towards the direction away from the first light guide section 110, and the light shielding cladding 200 is coated on the periphery of the light guide core 100 and defines a light transmission region 210.
The following describes the present embodiment specifically, taking the photodynamic treatment process of arm port red mole as an example.
The photosensitizer is injected or smeared on the skin of the arm, most of which is effectively focused on the lesion tissue site of the arm, wherein the skin includes the target skin and the non-target skin.
The non-target skin area of the skin is then masked with a black tape or a mask.
The second light guiding section 120 of the flexible light guiding structure 10 is bent, so that the light transmitting region 210 of the second light guiding section 120 of the flexible light guiding structure 10 is attached to the skin, and the therapeutic light a irradiates the target skin region of the skin.
In this embodiment, on the one hand, by the design that the aperture of the second light guiding section 120 decreases in the direction away from the first light guiding section 110, the total reflection of the therapeutic light a is destroyed, and meanwhile, the light shielding cladding 200 defines the light transmitting region 210, so that the therapeutic light a only exits from the light transmitting region 210, which can greatly improve the utilization rate of the therapeutic light a; on the other hand, the flexible light guide structure 10 adopts an integrated design, so that the whole structure is simplified and the flexible light guide structure can be better adapted to human skin.
2. As shown in fig. 5-8, a flexible wearable photodynamic therapy device, comprising: the therapeutic apparatus comprises a therapeutic apparatus body, a plurality of therapeutic light sources 20, a plastic lens group 30 and a flexible light guiding structure 10.
The plurality of therapeutic light sources 20 are arranged side by side and are used for emitting therapeutic light a with specific wave bands, the therapeutic apparatus body is electrically connected with the plurality of therapeutic light sources 20 and can selectively control the output power of each therapeutic light source 20, and the shaping lens group 30 is arranged in the outgoing direction of the therapeutic light a and is used for coupling the therapeutic light a into the flexible light guide structure 10.
The light-transmitting areas 210 of the flexible light-guiding structure 10 have a plurality of positions, the light-shielding cladding 200 between every two adjacent light-transmitting areas 210 is defined as a light-shielding area, the light-shielding area is opaque, and the therapeutic apparatus body is configured to control the output power of the therapeutic light source 20 corresponding to the light-shielding area to be 0.
The light-transmitting areas 210 at each place are hollowed out, the light-transmitting areas 210 at each place are correspondingly provided with an elastic dispersion layer 320, a first surface of the elastic dispersion layer 320 is connected with the second light guide section 120, and a second surface, adjacent to the first surface, of the elastic dispersion layer 320 is connected with the shading cladding 200.
The following will describe the present embodiment in detail with reference to the photodynamic treatment of arm port-flash moles.
The photosensitizer is injected or smeared on the skin of the arm, and most of the photosensitizer can be effectively focused on the lesion tissue part of the arm.
The second light guiding section 120 of the flexible light guiding structure 10 is bent, so that the light transmitting area 210 of the second light guiding section 120 of the flexible light guiding structure 10 is attached to the skin, and the elastic diffusion layer 320 at each place corresponds to the target skin of the skin.
The therapeutic light a emitted from the light-transmitting region 210 of the flexible light-guiding structure 10 is concentrated on the target skin by selectively controlling the output power of the therapeutic light source 20 corresponding to the non-target skin to be adjusted to 0 and controlling the output power of the therapeutic light source 20 corresponding to the target skin to reach the preset power through the therapeutic apparatus body.
Of course, when the therapeutic light a is transmitted from the elastic diffusion layer 320, it may also partially irradiate the non-target skin, and based on this, the size of the elastic diffusion layer 320 may be adjusted, for example, the elastic diffusion layer 320 is centrally disposed corresponding to the target skin, and the size of the elastic diffusion layer 320 is slightly smaller than the range of the target skin, so that the influence of the therapeutic light a on the target skin can be reduced as much as possible (as shown in fig. 8).
Compared with one embodiment, the step of shielding and protecting the non-target skin by using the black adhesive tape or the shielding cloth is omitted, and in addition, the accurate treatment on the target skin can be realized by controlling the output power of the treatment light source 20, so that the interference on the non-target skin is reduced; the treatment process is also more flexible, and the output power of the treatment light source 20 corresponding to the target skin can be adjusted according to the needs of patients and the characteristics of the target skin area of different lesions.
As shown in fig. 9, the present application further provides a method for using the flexible wearable photodynamic therapy device, including: step 510 and step 520.
Step 510, binding the flexible light guiding structure 10 to the limb, and the light transmitting area 210 of the flexible light guiding structure 10 faces the skin, wherein the skin comprises target skin and non-target skin.
Step 520, controlling the output power of the plurality of therapeutic light sources 20, so that the output power of the therapeutic light source 20 corresponding to the non-target skin is 0.
In this embodiment, the step of shielding and protecting the non-target skin with a black tape or a shielding cloth is omitted, and in addition, by controlling the output power of the therapeutic light source 20, the accurate treatment of the target skin can be realized, and the interference to the non-target skin is reduced; the treatment process is also more flexible, and the output power of the treatment light source 20 corresponding to the target skin can be adjusted according to the needs of patients and the characteristics of the target skin area of different lesions.
The above embodiments are not intended to limit the scope of the present application, so: all equivalent changes in structure, shape and principle of the application should be covered in the scope of protection of the application.
Claims (10)
1. A flexible light guide structure, comprising: a light guide core (100) and a light shielding cladding (200);
The light guide core (100) comprises a first light guide section (110) and a second light guide section (120) connected with the first light guide section (110), one end of the first light guide section (110) away from the second light guide section (120) can be coupled with incident therapeutic light (a), and the caliber of the second light guide section (120) is reduced towards the direction away from the first light guide section (110);
The shading cladding (200) is coated on the periphery of the light guide core (100), and the shading cladding (200) defines a light transmission area (210), and the light transmission area (210) emits the therapeutic light (a).
2. The flexible light guiding structure according to claim 1, wherein the second light guiding section (120) is provided with a reflective film (310) at least partially facing the light transmitting region (210).
3. The flexible light guiding structure according to claim 1, wherein the light transmitting area (210) is hollowed out, the light transmitting area (210) is provided with an elastic diffusion layer (320), a first surface of the elastic diffusion layer (320) is connected with the second light guiding section (120), and a second surface of the elastic diffusion layer (320) adjacent to the first surface is connected with the light shielding cladding (200).
4. A flexible light guiding structure according to any of claims 1-3, characterized in that the flexible light guiding structure is plate-like or cylindrical, and the longitudinal section of the second light guiding section (120) comprises two opposite surfaces, wherein the surface on the light exit side is inclined towards the other surface, so that the second light guiding section (120) tapers away from the first light guiding section (110).
5. The flexible light guiding structure according to claim 4, wherein a first magic tape (410) is provided on one side of the light shielding cladding (200) opposite to the second light guiding section (120), a second magic tape (420) is provided on the other side of the light shielding cladding (200) opposite to the first light guiding section (110), and the first magic tape (410) is adapted to be adhered to the second magic tape (420).
6. A flexible wearable photodynamic therapy device, comprising: a therapeutic apparatus body, a plurality of therapeutic light sources (20), a shaping lens set (30) and a flexible light guiding structure as claimed in any one of claims 1-5;
a plurality of said therapeutic light sources (20) arranged side by side and adapted to emit therapeutic light (a);
the therapeutic apparatus body is electrically connected with a plurality of therapeutic light sources (20) and can selectively control the output power of each therapeutic light source (20);
the shaping lens group (30) is arranged in the emergent direction of the therapeutic light (a) and is used for enabling the therapeutic light (a) to be coupled and incident into the flexible light guide structure.
7. The flexible wearable photodynamic therapy device according to claim 6, wherein the light-transmitting area (210) has a plurality of places, the light-shielding cladding (200) between each adjacent two of the light-transmitting areas (210) defining a light-shielding area, the light-shielding area being opaque, the therapy device body being configured to control the output power of the therapy light source (20) corresponding to the light-shielding area to be 0.
8. The flexible wearable photodynamic therapy device according to claim 6, characterized in that the shaping lens group (30) comprises: a slow axis collimating lens (31) and a fast axis focusing lens (32);
the slow axis collimating lens (31) and the fast axis focusing lens (32) are sequentially arranged along the emergent direction of the therapeutic light (a);
Wherein the slow axis collimating lens (31) is used for collimating the therapeutic light (a) in a slow axis, and the fast axis focusing lens (32) is used for focusing the therapeutic light (a) in a fast axis so as to enable the therapeutic light (a) to be coupled and incident into the flexible light guide structure.
9. The flexible wearable photodynamic therapy device according to claim 8, wherein the therapeutic light (a) is a laser beam;
The spot size of the laser beam formed by the fast axis focusing lens (32) is smaller than the thickness of the first light guide section (110); and/or the divergence angle of the laser beam is smaller than the acceptance angle of the first light guide section (110).
10. A method of using the flexible wearable photodynamic therapy device as claimed in claim 6, comprising:
binding a flexible light guiding structure to a limb, wherein a light transmitting area (210) of the flexible light guiding structure faces the skin of the limb, and the skin of the limb comprises target skin and non-target skin;
controlling the output power of the plurality of therapeutic light sources (20) so that the output power of the therapeutic light source (20) corresponding to the non-target skin is 0.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410279664.XA CN117959615A (en) | 2024-03-12 | 2024-03-12 | Flexible light guide structure, flexible wearable photodynamic therapeutic apparatus and use method thereof |
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| CN202410279664.XA CN117959615A (en) | 2024-03-12 | 2024-03-12 | Flexible light guide structure, flexible wearable photodynamic therapeutic apparatus and use method thereof |
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| CN117959615A true CN117959615A (en) | 2024-05-03 |
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