CN117936079A - Manifold learning-based diabetic retinopathy identification method, medium and system - Google Patents
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Abstract
The invention relates to the technical field of diabetic retinopathy identification, in particular to a method, medium and system for identifying diabetic retinopathy based on manifold learning. The recognition method of diabetic retinopathy based on manifold learning comprises inputting patient imaging examination result, extracting feature vector, splicing to form imaging feature matrix, and marking corresponding image to form examination result matrix; inputting physiological characteristics of a patient, and checking a checking result to construct a Laplacian matrix; constructing a prediction function by using a feature matrix and a Laplacian matrix based on manifold learning theory; solving to obtain an optimized mapping matrix; a predictive score matrix is calculated. The invention combines a plurality of machine learning techniques and improves the accuracy and the robustness of the model. The model can provide accurate and reliable auxiliary diagnostic tools for ophthalmologists, is beneficial to early discovery of diabetic retinopathy, improves treatment effect and reduces social and family burden.
Description
Technical Field
The invention relates to the crossing technical field of artificial intelligence and diabetic retinopathy identification, in particular to a method, medium and system for identifying diabetic retinopathy based on manifold learning.
Background
Diabetic retinopathy (Diabetic Retinopathy, DR) is one of the most common complications of diabetics, severely affecting the eyesight and quality of life of the patient. Early DR patients often have no obvious symptoms, but progressive DR can cause macular edema, neovascularization with secondary glass-volumetric blood and even retinal detachment, etc., with significant vision hazards. Together with the irreversibility of DR disease progression, early diagnosis and treatment are therefore critical for preventing and alleviating progression of DR lesions. In clinic, diagnosis of DR mainly depends on experienced fundus disease specialists to directly perform fundus examination on a patient or observe and evaluate fundus images of the patient.
The traditional fundus image analysis method has a plurality of problems such as difficult feature extraction, low classification accuracy and the like. The disclosed deep learning model (such as CN116152229B, a method for constructing a diabetic retinopathy diagnosis model and a diagnosis model) can extract pathological features from marked data, but has the defects of poor interpretability and the like. In addition, a single machine learning algorithm often cannot fully utilize information in fundus images, resulting in low recognition accuracy. Secondly, the existing method has the problems of difficult feature selection, complex model fusion and the like when processing fundus images, and limits the application of the method in diabetic retinopathy identification.
In recent years, machine learning techniques have made remarkable progress in the field of medical image analysis. Manifold learning is a technique that takes into account data distribution characteristics, and can effectively extract important characteristics of unlabeled samples in fundus images. Subspace regression is a regression method based on subspace decomposition, and the fitting capacity and generalization capacity of a model are improved by communicating local and whole. Sparse learning is a method for extracting features through sparse representation, and can reduce redundant features and noise interference.
Therefore, the invention provides a method, medium and system for identifying diabetic retinopathy based on manifold learning, aiming at improving the accuracy and efficiency of early diagnosis of diabetic retinopathy. The method integrates various machine learning technologies such as manifold learning, subspace regression, sparse learning and the like, combines the method into a unified model by constructing a loss function, can fully utilize information in fundus images, and improves recognition accuracy and robustness.
Disclosure of Invention
The invention aims to provide a manifold learning-based diabetic retinopathy identification method, medium and system with simple feature extraction and high accuracy.
In order to solve the problems, the technical scheme provided by the invention is as follows: a method for identifying diabetic retinopathy based on manifold learning comprises
Step one, inputting a patient imaging examination result, extracting feature vectors, splicing to form an imaging feature matrix, and marking a corresponding image to form an examination result matrix, wherein the method specifically comprises the following steps:
Inputting the image inspection results of the color fundus photography and optical coherence tomography of a patient, extracting three types of characteristics of a color correlation chart, a wavelet texture and an edge direction histogram to form characteristic vectors, splicing the characteristic vectors of each image to form an imaging characteristic matrix, marking as X, wherein the number of lines is the image sample quantity n, and the number of columns is the characteristic number; marking each inspection result image in sequence according to a given column, wherein the corresponding columns are respectively: microangioma, hard exudation, punctiform hemorrhage, flaky hemorrhage, soft exudation, glass volume blood, new blood vessel, microangioma, multiple bleeding points, fibroplasia, retinal detachment, if the conditions are met, the corresponding position is marked as 1, otherwise, the corresponding position is marked as 0, an inspection result matrix is marked as Y, the number of lines of the matrix Y is the image sample quantity n, and the number of columns is the result characteristic number;
Inputting physiological characteristics of a patient and checking results, and constructing a Laplacian matrix L, wherein the method comprises the following steps of:
physiological characteristics, inspection test results, specifically include: vision, age, sex, family history of diabetes, course of diabetes, type 1/2 diabetes, whether diabetic nephropathy is associated, whether peripheral neuropathy is associated, and fasting blood glucose levels; glycosylated hemoglobin, 7 random blood glucose values (blood glucose before meal and blood glucose after meal for two hours before sleep in the morning, in the evening), whether insulin is injected, whether hyperlipidemia, and a history of hypertension.
The method for constructing the Laplace matrix L comprises the following steps: firstly, standardizing quantitative data to a range of 0-1, then calculating Gaussian distances by using a Gaussian radial basis function to represent similarity between two cases of patients, wherein a matrix L is a patient similarity matrix which is obtained by summing according to columns and subtracting the patient similarity matrix from a diagonalized result;
Thirdly, constructing a prediction function by using a feature matrix and a Laplacian matrix based on manifold learning theory:
;
Wherein F is a prediction result scoring matrix (to be solved), and G is a mapping matrix (to be solved); item 1 is a laplace regularization item, where Tr () represents the trace of the matrix and T represents the transpose of the matrix; the 2 nd item is a reconstruction loss item, and the difference between the prediction score matrix and the original matrix is measured, wherein U represents a decision rule matrix; item 3 is a subspace regression term, and communicates a prediction result score matrix F and an imaging feature matrix X, wherein mu is a regularization coefficient, and I F represent a matrix F norm; item 4 is a matrix norm item, |·| 2,1 represents the L 2,1 matrix norm;
step four, solving the prediction function and outputting an optimized mapping matrix G;
Step five, calculating a prediction score matrix f=x T G.
A medium of a method for identifying diabetic retinopathy based on manifold learning, comprising a storage medium and a processing medium; the storage medium is used for storing fundus image data and parameters of the training model, and the processing medium is used for executing each step in the diabetic retinopathy identification method.
The system of the diabetic retinopathy recognition method based on manifold learning comprises an image acquisition module, a feature extraction module, a model training module and a recognition module; the image acquisition module is used for acquiring fundus image data of a diabetic patient, the characteristic extraction module is used for extracting manifold characteristic representation of the fundus image, the model training module is used for training an optimized prediction model, and the identification module is used for identifying diabetic retinopathy on a new fundus image.
The beneficial effects of the invention are as follows: the invention combines various machine learning technologies such as manifold learning, subspace regression, sparse learning and the like, fully utilizes the advantages of each machine, and improves the accuracy and the robustness of the model; the model can provide an accurate and reliable auxiliary diagnosis tool for doctors, is favorable for early discovery and identification of diabetic retinopathy, and improves the treatment effect and the life quality of patients.
Drawings
FIG. 1 is a flow chart of a method for recognition of diabetic retinopathy based on manifold learning;
FIG. 2 is a frame diagram of a diabetic retinopathy identification medium based on manifold learning;
Fig. 3 is a block diagram of a manifold learning based diabetic retinopathy identification system.
Detailed Description
Preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings.
As shown in FIG. 1, a method for identifying diabetic retinopathy based on manifold learning comprises
Inputting imaging examination results of a patient color fundus camera and optical coherence tomography, extracting three types of features, including a color correlation diagram, wavelet textures and edge direction histograms to form feature vectors, splicing the feature vectors of each image to form an imaging feature matrix, marking the feature matrix as X, wherein the number of rows of the matrix X is the number of images n, and the number of columns is the feature number, if 345, marking each examination result image in sequence according to a given column, and the corresponding columns are respectively: microangioma, hard exudation, punctiform hemorrhage, flaky hemorrhage, soft exudation, glass volume blood, new blood vessel, microangioma, multiple bleeding points, fibroplasia, retinal detachment, if the conditions are met, the corresponding position is marked as1, otherwise, the corresponding position is marked as 0, an inspection result matrix is marked as Y, the number of lines of the matrix Y is the number of images n, and the number of columns is the number of result characteristics 8;
Inputting physiological characteristics of a patient and checking results, and constructing a Laplacian matrix L, wherein the method comprises the following steps of:
Physiological characteristics, inspection test results, specifically include: vision, age, sex, family history of diabetes, course of diabetes (time to diabetes), type 1/2 of diabetes, whether to incorporate diabetic nephropathy, whether to incorporate diabetic peripheral neuropathy, fasting blood glucose (fasting blood glucose is the venous blood glucose value in the morning); glycosylated hemoglobin, 7 random blood glucose values (blood glucose before meal and blood glucose after meal for two hours before sleep, fingertip blood glucose values) whether insulin is injected, whether hyperlipidemia, and a history of hypertension;
The method for constructing the Laplace matrix L comprises the following steps: firstly, standardizing the physiological characteristics of a patient and quantitative data in an examination and test result to a range of 0-1, and in this case, scaling eyesight, age, glycosylated hemoglobin, random blood sugar and blood fat to a range of 0,1 by using a 0-1 standardization method; then, gaussian radial basis function G (p i,pj) = exp(-||pi-pj||2/gamma) is used to calculate Gaussian distance, G (p i,pj) represents similarity between corresponding input vectors p i and p j of two cases of patients, wherein ||·| represents the euclidean distance is used to determine, gamma is the width parameter of the gaussian function, here taken as 1; the matrix L is the patient similarity matrix subtracted from the diagonalized result after summing the patient similarity matrix according to columns;
Thirdly, constructing a prediction function by using a feature matrix and a Laplacian matrix based on manifold learning theory:
;
Wherein F is a prediction result scoring matrix (to be solved), and G is a mapping matrix (to be solved); item 1 is a laplace regularization item, where Tr () represents the trace of the matrix and T represents the transpose of the matrix; the 2 nd item is a reconstruction loss item, and the difference between the prediction score matrix and the original matrix is measured, wherein U represents a decision rule matrix; item 3 is a subspace regression term, and communicates a prediction result score matrix F and an imaging feature matrix X, wherein mu is a regularization coefficient, and I F represent a matrix F norm; item 4 is a matrix norm item, |·| 2,1 represents the L 2,1 matrix norm;
step four, solving the prediction function, inputting an imaging feature matrix X, checking a result matrix Y, a manifold regularization matrix L and taking a unit matrix from the decision rule matrix U; calculating an intermediate process matrix Wherein A is the full one matrix of equal size minus one-half the number of samples, and then the intermediate process matrix/>, is calculatedCalculating the intermediate process matrix/>Let the number of loops t=0, randomly initialize G 0, repeatedly calculate the diagonal matrix D t, update/>Where t=t+l until convergence; and (3) outputting: optimizing the mapping matrix G;
step five, calculating a prediction score matrix F=X T G;
in the actual use process of the model, five-fold cross validation is used for further optimizing parameters. The five-fold cross validation method evaluates the diabetic retinopathy identification model as follows: first, the entire data set is randomly divided into five mutually exclusive subsets, four of which serve as training sets for the model and the other as verification set. Then, a different subset is selected as the verification set at a time, and the rest are used as training sets. During each training process, the model is trained using a training set and performance assessment is performed on a validation set. Finally, we average the five validation results to arrive at a final performance assessment index for the model, including but not limited to accuracy, sensitivity, specificity, etc. The performance of the model is evaluated through five-fold cross verification, and the performance of the model in different parameters is verified, so that the parameters are further optimized, and the robustness and the reliability of the model are ensured.
As shown in fig. 2, the medium of the manifold learning-based diabetic retinopathy identification method comprises a storage medium and a processing medium; the storage medium is used for storing fundus image data and parameters of the training model, and the processing medium is used for executing each step in the diabetic retinopathy identification method.
As shown in fig. 3, the system of the recognition method of diabetic retinopathy based on manifold learning comprises an image acquisition module, a feature extraction module, a model training module and a recognition module; the image acquisition module is used for acquiring fundus image data of a diabetic patient, the characteristic extraction module is used for extracting manifold characteristic representation of the fundus image, the model training module is used for training an optimized prediction model, and the identification module is used for identifying diabetic retinopathy on a new fundus image.
Working principle: the invention provides a manifold learning-based diabetic retinopathy identification method, medium and system, aiming at improving the early diagnosis accuracy and efficiency of diabetic retinopathy. The method integrates various machine learning technologies such as manifold learning, subspace regression, sparse learning and the like, and can fully utilize information in fundus images by constructing a loss function combination into a unified model, thereby improving recognition accuracy and robustness. The invention combines various machine learning technologies such as manifold learning, subspace regression, sparse learning and the like, fully utilizes the advantages of each machine learning technology, improves the accuracy and the robustness of the model, can provide an accurate and reliable auxiliary diagnosis tool for doctors, is beneficial to early discovery and treatment of diabetic retinopathy identification, and improves the treatment effect and the life quality of patients.
The invention and its embodiments have been described above with no limitation, and the actual construction is not limited to the embodiments of the invention as shown in the drawings. In summary, if one of ordinary skill in the art is informed by this disclosure, a structural manner and an embodiment similar to the technical solution should not be creatively devised without departing from the gist of the present invention.
Claims (6)
1. The method for identifying the diabetic retinopathy based on manifold learning is characterized by comprising the following steps of:
step one, inputting a patient imaging examination result, extracting feature vectors, splicing to form an imaging feature matrix, and marking a corresponding image to form an examination result matrix, wherein the method specifically comprises the following steps:
Inputting the patient image inspection result, extracting features to form feature vectors, and splicing the feature vectors to form an imaging feature matrix; marking each inspection result image in sequence according to a given column, marking the corresponding position as 1 if the inspection result images accord with the given column, and marking the corresponding position as 0 if the inspection result images accord with the given column, so as to form an inspection result matrix;
Inputting physiological characteristics of a patient and checking results, and constructing a Laplacian matrix L, wherein the method comprises the following steps of:
The method for constructing the Laplace matrix L comprises the following steps: firstly, standardizing quantitative data to a range of 0-1, then calculating Gaussian distances by using a Gaussian radial basis function to represent similarity between two cases of patients, wherein a matrix L is a patient similarity matrix which is obtained by summing according to columns and subtracting the patient similarity matrix from a diagonalized result;
Thirdly, constructing a prediction function by using a feature matrix and a Laplacian matrix based on manifold learning theory;
Step four, solving the prediction function and outputting an optimized mapping matrix;
and fifthly, calculating a prediction score matrix.
2. The manifold learning-based diabetic retinopathy identification method according to claim 1, wherein: in the first step, each inspection result image is marked in sequence according to a given column, and the corresponding columns are respectively: microangiomas, hard exudation, punctate bleeding, platelet bleeding, soft exudation, glass-volume blood, neovasculature, microangiomas, multiple bleeding sites, fibroplasia, retinal detachment.
3. The manifold learning-based diabetic retinopathy identification method according to claim 1, wherein: in the second step, the physiological characteristics and the checking and checking results specifically comprise: vision, age, sex, family history of diabetes, course of diabetes, type 1/2 diabetes, whether diabetic nephropathy is associated, whether peripheral neuropathy is associated, and fasting blood glucose levels; glycosylated hemoglobin, 7 random blood glucose values, whether insulin is injected, whether hyperlipidemia, and a history of hypertension, wherein the 7 random blood glucose values refer to a pre-meal blood glucose value of three meals a morning, a evening, a two hour meal and a pre-sleep blood glucose value.
4. The manifold learning-based diabetic retinopathy identification method according to claim 1, wherein: in the third step, the prediction function is:
;
Wherein F is a prediction result scoring matrix, Y is an inspection result matrix, G is a mapping matrix, F, G are all matrices to be solved; item 1 is a laplace regularization item, where Tr () represents the trace of the matrix and T represents the transpose of the matrix; the 2 nd item is a reconstruction loss item, and the difference between the prediction score matrix and the original matrix is measured, wherein U represents a decision rule matrix; item 3 is a subspace regression term, and communicates a prediction result score matrix F and an imaging feature matrix X, wherein mu is a regularization coefficient, and I F represent a matrix F norm; item 4 is a matrix norm item, |·| 2,1 represents the L 2,1 matrix norm.
5. The medium of the manifold learning-based diabetic retinopathy identification method according to claim 1, wherein: including a storage medium and a processing medium; the storage medium is used for storing fundus image data and parameters of the training model, and the processing medium is used for executing each step in the diabetic retinopathy identification method.
6. The system of manifold learning based diabetic retinopathy identification method according to claim 1, wherein: the system comprises an image acquisition module, a feature extraction module, a model training module and an identification module; the image acquisition module is used for acquiring fundus image data of a diabetic patient, the characteristic extraction module is used for extracting manifold characteristic representation of the fundus image, the model training module is used for training an optimized prediction model, and the identification module is used for identifying diabetic retinopathy on a new fundus image.
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