CN117929213A - Method for measuring deposition rate of volatile organic compounds in atmospheric particulates in human respiratory tract and application thereof - Google Patents
Method for measuring deposition rate of volatile organic compounds in atmospheric particulates in human respiratory tract and application thereof Download PDFInfo
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- 239000012855 volatile organic compound Substances 0.000 title claims abstract description 64
- 230000008021 deposition Effects 0.000 title claims abstract description 46
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Abstract
The invention belongs to the field of atmospheric particulate toxicity evaluation in the aspect of environmental health risk evaluation, and discloses a method for measuring the deposition rate of volatile organic compounds in atmospheric particulate in human respiratory tract and application thereof. The method comprises the steps of detecting the composition and concentration of volatile organic compounds on the particles in the atmosphere, and selecting volatile organic compound data with the concentration of the volatile organic compounds higher than the concentration of the corresponding particles in the atmosphere as deposition substances in the respiratory tract of the human body; the concentration of volatile organic compounds in the atmospheric particulate matters is divided by the difference of the concentration of the volatile organic compounds in the atmospheric particulate matters subtracted from the concentration level of the particulate matters exhaled by the human body, and the deposition rate of the obtained volatile organic compounds in the respiratory tract of the human body is obtained. The method is simple to operate and high in sensitivity, can perform real-time online qualitative and quantitative detection on volatile organic compounds in exhaled air and atmospheric particulates of a human body, calculates the deposition rate of the volatile organic compounds in the respiratory tract of the human body, and can evaluate environmental exposure and other researches.
Description
Technical Field
The invention belongs to the field of atmospheric particulate toxicity evaluation in the aspect of environmental health risk evaluation, and particularly relates to a method for measuring the deposition rate of volatile organic compounds in atmospheric particulate in human respiratory tract and application thereof.
Background
Human activity emits toxic volatile organic compounds which are potentially harmful to health, atmospheric toxic volatile organic compounds can exist in a balance between a gas phase and a particle phase, part of the gas phase volatile organic compounds can be adsorbed on the surface of the particles, and the volatile organic compounds combined with the particles can reach certain areas of a respiratory system. In addition, small particle size particles can reach the alveolar region of the human respiratory system, while large particle size particles can only stay in the nasopharyngeal site. The health effects produced by different particle size particulates in different parts of the respiratory system vary. It is therefore highly necessary to assess the health risk of toxic volatile organic compounds in the atmospheric environment on particulate matter of different particle sizes. The deposition rate of the particulate matters in the respiratory system of the human body is a key for understanding the health effect of toxic volatile organic matters of the atmospheric particulate matters. The atmospheric particulate deposition rate is determined primarily by subtracting the concentration level of exhaled human body from the concentration level of inhaled atmospheric particulate, the difference divided by the concentration level of inhaled atmospheric particulate. However, the deposition rate of atmospheric particulate matters is only considered to be a few concentration levels, but the deposition rate of toxic volatile organic matters in the particulate matters is not established.
Disclosure of Invention
Aiming at the defects of the prior art, the primary aim of the invention is to provide a method for measuring the deposition rate of volatile organic compounds in particulate matters in atmospheric particulate matters in human respiratory tract. The complex and time-consuming sample pretreatment is avoided, the collection method for monitoring the volatile organic compounds in the particulate matters on line in real time can be realized, and the accuracy of detecting the volatile organic compounds adsorbed on the particulate matters is improved.
It is a further object of the invention to provide a system for implementing said method.
It is a further object of the present invention to provide the use of the above system.
The aim of the invention is achieved by the following technical scheme:
A method for measuring the deposition rate of volatile organic compounds in atmospheric particulates in human respiratory tract comprises the following steps:
S1, collecting human exhaled air by using a Teflon sampling bag, screening the particle size of exhaled air particles by using a scanning electromigration particle size spectrometer, and detecting the composition and concentration of volatile organic compounds with various proton affinities greater than water on the particles in the human exhaled air by combining a real-time analysis sample injection system with a proton transfer reaction flight time mass spectrometer;
S2, directly screening and detecting the particle size of the environmental atmospheric particulates where the crowd is located by using a scanning electromigration particle size spectrometer, and detecting the composition and concentration of volatile organic compounds with various proton affinities greater than water on the atmospheric environmental particulates by using an aerosol chemical composition real-time analysis sample injection system combined with a proton transfer reaction flight time mass spectrometer;
s3, analyzing the concentrations of various volatile organic compounds on the human exhaled breath and the environmental atmospheric particulate matters according to the step S1 and the step S2, comparing the concentration differences of the two, and selecting volatile organic compound data with the concentration of the volatile organic compounds on the atmospheric environmental particulate matters being higher than the concentration of the corresponding human exhaled particulate matters as deposition substances on the respiratory tract of the human body;
S4, subtracting the concentration level of volatile organic matters with various proton affinities larger than water from the concentration level of volatile organic matters with various proton affinities larger than water on the particles exhaled by the human body, and dividing the difference by the concentration level of various volatile organic matters in the atmospheric particles to obtain the deposition rate of various volatile organic matters with various proton affinities larger than water in the atmospheric particles with different particle diameters in the respiratory tract of the human body.
Preferably, the exhaled breath of the person in step S1 is the subject' S filling the teflon sampling bag with a disposable mouthpiece.
Preferably, the parameters of the scanning electromigration particle size spectrometer in the steps S1 and S2 are set as follows: the sheath gas flow rate is 3-15L/min, the sampling flow rate is 0.3-1.5L/min, and the scanning time is 30-500S, so that the differential electromigration rate analyzer in the scanning electromigration particle size spectrometer in the steps S1 and S2 screens out the particles in the target particle size section at 10-1000 nm for counting and detection.
Preferably, the parameters of the real-time analysis sample injection system for aerosol chemical components in steps S1 and S2 are set as follows: the thermal desorption temperature is 50-200 ℃, the energy level E/N value of the drift tube is 60-150 TD, wherein E is the electric field strength, the unit is 1TD= -17V cm2, and N is the number density of neutral gas.
Preferably, the volatile organic compounds with proton affinity greater than that of water in the steps S1-S4 are more than one of formaldehyde, toluene, acetaldehyde, acetonitrile, acetone, quinoline or dimethylnaphthalene.
Preferably, the specific detection method for the composition and concentration of each volatile organic compound in the steps S1 and S2 is as follows: the fluorine dragon sampling bag is connected to a particle filter through one end of a three-way valve, the other end of the fluorine dragon sampling bag is connected to a drying pipe, then particles with different particle size sections are screened out by an electrostatic classifier and a differential electric mobility analyzer, then 1 three-way valve is connected to enable one part of gas to enter a condensation nucleus particle counter for counting, the other part of gas enters an aerosol chemical component real-time analysis sampling system, organic gas is efficiently adsorbed by a gas phase filter and particles are conveyed, then the particles are enriched by an aerodynamic lens, then organic components in the particles are volatilized to a gas phase by a thermal analyzer, and finally volatile organic matters are detected by a proton transfer reaction time-of-flight mass spectrum through a soft ionization mode by using H 3O+. After sampling of one particle size section is carried out by opening the valve of the air collecting bag, before switching to the next particle size section, the valve of the air collecting bag is closed, the valve connected with the particle filter is opened, residual particles in the connecting pipeline are washed clean by using gas without the particles, and then sampling of the next particle size section is carried out.
Specifically, the concentration data analysis of the selective volatile organic compounds in step S3 is as follows: in the data of various volatile organic compounds in the particle phase, each breath sample reaches a peak value and keeps stable, and the data after the expiration rises to be stable is selected according to the expiration curve indicated by acetaldehyde ((C 2H4O)H+ m/z 45.03) of each breath sample, so that the sampling accuracy is ensured.
The system comprises a Teflon sampling bag, an aerosol chemical composition real-time analysis sampling system, a proton transfer reaction time-of-flight mass spectrometer, a scanning electromobility particulate particle size spectrometer, a single-tube dryer and a high-efficiency microparticle air capsule filter; the real-time online analysis and sample injection system for the chemical components of the aerosol comprises a gas phase filter, an aerodynamic lens and a thermal desorption device; the proton transfer reaction time-of-flight mass spectrum comprises an ion source, a drift tube, a mass analyzer and an ion detector; the scanning electric mobility particle size spectrometer comprises an electrostatic classifier, a differential electric mobility analyzer and a condensation nucleus particle counter. The Teflon sampling bag is connected to a particle filter through one end of a three-way valve, the other end of the Teflon sampling bag is connected to a drying pipe, then particles with different particle size sections are screened out by the electrostatic classifier and the differential electric mobility analyzer, then a three-way valve is connected to enable a part of gas to enter a condensation nuclear particle counter for counting, a part of gas enters an aerosol chemical composition real-time analysis sampling system, organic gas is efficiently adsorbed by a gas phase filter and the particles are conveyed, then the particles are enriched by an aerodynamic lens, then organic components in the particles are volatilized to a gas phase by a thermal analyzer, and finally the organic matters are detected through proton transfer reaction time-of-flight mass spectrometry.
The method for measuring the deposition rate of the volatile organic compounds in the atmospheric particulates in the human respiratory tract is applied to the field of environmental exposure evaluation.
The system comprises a Teflon sampling bag, an aerosol chemical component real-time analysis sampling system, a proton transfer reaction time-of-flight mass spectrum (CHARON PTR-TOF-MS), a scanning electric mobility particulate matter particle size spectrometer (Scanning Mobility Particle Sizer), a single-tube dryer (Monotube Dryer) and a high-efficiency particulate air capsule filter; the real-time online analysis and sample injection system for the chemical components of the aerosol comprises a gas phase filter, an aerodynamic lens and a thermal desorption device; the proton transfer reaction time-of-flight mass spectrum comprises an ion source, a drift tube, a mass analyzer and an ion detector; the scanning electric mobility particle size spectrometer comprises an electrostatic classifier, a differential electric mobility analyzer and a condensation nucleus particle counter.
Compared with the prior art, the invention has the following beneficial effects:
1. The invention establishes a method for rapidly and simply monitoring the deposition rate of various volatile organic compounds in human body atmospheric particulates in real time in human body respiratory tract, avoids complex and time-consuming pretreatment steps of samples, directly realizes on-line detection, and can screen different particle size sections and check the real-time concentration of the selected volatile organic compounds in the measuring process.
2. According to the invention, based on the real-time online analysis of aerosol chemical components and the combination of a proton transfer reaction time-of-flight mass spectrum (CHARON PTR-TOF-MS), the volatile organic compounds in the particles can be continuously, qualitatively and quantitatively monitored, the system can screen the particles and simultaneously conduct real-time online analysis on various volatile organic compounds in the particles, the minimum detection limit for detecting the particles can reach 0.0025 mu m, and the detection concentration is 1-10 8 per cm 3 at most; the minimum detection limit for detecting trace volatile organic compounds reaches a few pptv, the detection range is usually from a few ppt to hundreds of ppb, and the accuracy of detecting the content of volatile organic compounds in the particulate matters can be improved.
3. According to the method, the composition characteristics and concentration levels of toxic and harmful volatile organic compounds in the particles with different particle sizes are measured under the conditions of exhaled air and atmospheric environment of a human body, and the deposition rate of the toxic and harmful volatile organic compounds in the particles with different particle sizes is calculated and obtained, so that important technical means and support are provided for evaluating the health effect of inhalable atmospheric particles. The complex and time-consuming sample pretreatment is avoided, the collection method for monitoring the volatile organic compounds in the particulate matters on line in real time can be realized, and the accuracy of detecting the volatile organic compounds adsorbed on the particulate matters is improved.
Drawings
FIG. 1 is a schematic diagram of the on-line collection method of various volatile organic compounds in the atmospheric particulates.
FIG. 2 is a flow chart of the method for measuring and analyzing the deposition rate of volatile organic compounds in the air particles in human respiratory tract in example 1.
FIG. 3 shows the deposition rate of dimethylnaphthalene and quinoline, harmful to atmospheric particulates, in the human respiratory tract, in example 2.
Detailed Description
The following description of the technical solutions in the embodiments of the present disclosure will be made clearly and completely with reference to the accompanying drawings in the embodiments of the present disclosure, and it is apparent that the described embodiments are only some embodiments of the present disclosure, not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art based on the embodiments in this disclosure without inventive faculty, are intended to fall within the scope of this disclosure.
Example 1
1. Subjects were exhaled for sampling 2 hours after eating, during which time no diet was allowed until sampling was completed, except for drinking water.
2. In order to remove the pollutants possibly existing in the Teflon sampling bag 1, high-purity nitrogen is required to be repeatedly flushed for not less than 5 times (after the bag is filled, the gas in the bag is pumped by a pump), in order to ensure the accuracy of experimental data, the nitrogen is introduced into the Teflon sampling bag 1 after the Teflon sampling bag 1 is flushed for 1-2min, and then CHARON PTR-TOF-MS is used for detecting the Teflon sampling bag 1 as a blank sample.
3. The method comprises the steps of filling a Teflon sampling bag 1 through a disposable mouthpiece during normal nasal inhalation of a subject, connecting one end of the Teflon sampling bag 1 to a particle filter 2 through a three-way valve 3, connecting the other end of the Teflon sampling bag to a drying pipe 4, then entering an electrostatic classifier and a differential electric mobility analyzer 5, screening out particles with different particle size sections by controlling setting parameters on a computer, then entering a three-way valve 7 to enable a part of gas to enter a condensation nucleus particle counter 6 for counting, enabling a part of gas to enter an aerosol chemical composition real-time analysis sampling system (CHRON) 8, efficiently adsorbing organic gas by a gas phase filter and conveying the particles, enriching and secondarily sampling the particles by an aerodynamic lens, then enabling a thermal analyzer to convert the organic ammonium radical of the particles into a gas phase, finally detecting the organic matters through a proton transfer reaction flight time mass spectrum 9 by using a hydronium ion method through soft ionization mode, and then drawing a mass spectrum and transmitting the organic matters to a computer display screen. After sampling of one particle size section is carried out by opening the valve of the air collection bag 1, before switching to the next particle size section, the valve of the air collection bag 1 is closed, the valve connected with the particle filter 2 is opened, residual particles in the connecting pipeline are washed clean by using gas without the particles, and then sampling of the next particle size section is carried out.
The optimal parameters are obtained based on exploration: the thermal desorption temperature of the aerosol chemical component on-line real-time analysis sample injection system is 50-200 ℃, the energy level (E/N) value of the drift tube is 60-150 TD (E is electric field intensity, the unit is 1 TD=10 -17V cm2, and N is the number density of neutral gas). The sheath gas flow rate of the scanning electromigration particle size spectrometer is 3-15L/min, the sampling flow rate is 0.3-1.5L/min, and the scanning time is 30-500 s.
In the embodiment, the particle detection of 300-400 nm is selected, the deposition rate of dimethylnaphthalene in the respiratory tract of a human body is detected, the thermal desorption temperature of an online real-time analysis sample injection system of aerosol chemical components is adjusted to 120 ℃, the energy level E/N value of a drift tube is 80TD, the sheath gas flow rate of a scanning electromigration particle size spectrometer is 3L/min, the sampling flow rate is 0.3L/min, and the scanning time is 180s. The deposition rate of dimethylnaphthalene in human respiratory tract is 9%. After inhalation, only a small part of the dimethylnaphthalene is absorbed by the respiratory tract of a human body, and the rest of the dimethylnaphthalene is discharged through exhalation, so that different deposition rates of volatile organic compounds on the particulate matters are analyzed and calculated, and the uncertainty of health risk assessment is reduced.
FIG. 1 is a schematic diagram of the on-line collection method of various volatile organic compounds in exhaled air particulate matters. The device comprises a Teflon sampling bag 1, a particle filter 2, three-way valves (3 and 7), a single-tube dryer (Monotube Dryer and 700) 4, a scanning electric mobility particle size spectrometer (SMPS) (5-6), an aerosol chemical component real-time analysis sampling system (CHARON) 8 and a proton transfer reaction time-of-flight mass spectrum (PTR-TOF-MS) 9. As can be seen from fig. 1, the teflon sampling bag is connected to the particle filter at one end through a three-way valve, and connected to the drying tube at the other end, then enters the electrostatic classifier and the differential electromigration analyzer to screen out the particles with different particle size sections, then enters a three-way valve to make a part of gas enter the condensation nucleus particle counter for counting, and a part of gas enters the aerosol chemical composition real-time analysis sample injection system to efficiently adsorb organic gas and transmit the particles through the gas phase filter, then enriches the particles through the aerodynamic lens, then the thermal analyzer volatilizes the organic components in the particles to the gas phase, and finally the organic matters are detected through proton transfer reaction time-of-flight mass spectrometry. FIG. 2 is a flow chart of the method for measuring and analyzing the deposition rate of volatile organic compounds in the air particles in human respiratory tract in example 1. As can be seen from fig. 2, the deposition rate of toxic volatile organic compounds in the particulate matters with different particle sizes is calculated and obtained by sampling the crowd and the atmospheric environment, screening the particle sizes of the particulate matters and detecting the concentration of the volatile organic compounds on the particulate matters on line, and analyzing and processing the concentration relation between the exhaled air of the human body and the volatile organic compounds in the particulate matters in the corresponding atmospheric environment.
Example 2
The difference from example 1 is that: the detection substance in the parameter setting of this embodiment is quinoline. The detection result shows that when particles with the wavelength of 300-400nm are selected for detection, the thermal desorption temperature of an aerosol chemical component on-line real-time analysis sampling system is regulated to be 110 ℃, the energy level E/N value of a drift tube is 80TD, the sheath gas flow rate of a scanning electromigration particle size spectrometer is 3L/min, the sampling flow rate is 0.3L/min, and the scanning time is 180s. The deposition rate of quinoline in human respiratory tract is 10%.
FIG. 3 shows the deposition rate of dimethylnaphthalene and quinoline, harmful to atmospheric particulates, in the human respiratory tract, in example 2. As can be seen from FIG. 3, the deposition rates of dimethylnaphthalene and quinoline in the human respiratory tract in the 300-400 nm atmospheric particulates were 9% and 10%, respectively. The deposition rates of the atmospheric particulates with different particle diameters on the respiratory tract of a human body are different, quinoline is easier to deposit on the respiratory tract of the human body compared with dimethylnaphthalene, and the hazard risk of different substances on the human body can be judged through the deposition rates in later researches.
Example 3
The difference from example 1 is that: the particle size section of the particulate matters in the parameter setting of the embodiment is 200-300 nm. The detection result shows that when the particles with the wavelength of 200-300 nm are selected for detection, the thermal desorption temperature of an aerosol chemical component on-line real-time analysis sampling system is regulated to be 110 ℃, the energy level E/N value of a drift tube is 80TD, the sheath gas flow rate of a scanning electromigration particle size spectrometer is 3L/min, the sampling flow rate is 0.3L/min, and the scanning time is 180s. The deposition rate of dimethylnaphthalene in human respiratory tract is 3.4%.
Example 4
The difference from example 1 is that: the thermal desorption temperature in the parameter setting of this example was 110 ℃. The detection result shows that when particles with the wavelength of 300-400nm are selected for detection, the thermal desorption temperature of an aerosol chemical component on-line real-time analysis sampling system is regulated to be 110 ℃, the energy level E/N value of a drift tube is 80TD, the sheath gas flow rate of a scanning electromigration particle size spectrometer is 3L/min, the sampling flow rate is 0.3L/min, and the scanning time is 180s. The dimethylnaphthalene deposition rate was found to be 26%.
Example 5
The difference from example 1 is that: the sheath gas flow rate of the scanning electromigration particle size spectrometer in the parameter setting of the embodiment is 5L/min. The detection result shows that when particles with the wavelength of 300-400 nm are selected for detection, the thermal desorption temperature of an aerosol chemical component on-line real-time analysis sampling system is regulated to be 110 ℃, the energy level E/N value of a drift tube is 80TD, the sheath gas flow rate of a scanning electromigration particle size spectrometer is 5L/min, the sampling flow rate is 0.3L/min, and the scanning time is 180s. The deposition rate of dimethylnaphthalene in human respiratory tract is 11%.
Example 6
The difference from example 1 is that: the sampling flow rate in the parameter setting of this embodiment is 1.5L/min. The detection result shows that when particles with the wavelength of 300-400 nm are selected for detection, the thermal desorption temperature of an aerosol chemical component on-line real-time analysis sampling system is regulated to be 110 ℃, the energy level E/N value of a drift tube is 80TD, the sheath gas flow rate of a scanning electromigration particle size spectrometer is 3L/min, the sampling flow rate is 1.5L/min, and the scanning time is 180s. The deposition rate of dimethylnaphthalene in human respiratory tract is 15%.
Example 7
The difference from example 1 is that: the scan time in the parameter setting of this embodiment is 120s. The detection result shows that when particles with the wavelength of 300-400 nm are selected for detection, the thermal desorption temperature of an aerosol chemical component on-line real-time analysis sampling system is regulated to be 110 ℃, the energy level E/N value of a drift tube is 80TD, the sheath gas flow rate of a scanning electromigration particle size spectrometer is 3L/min, the sampling flow rate is 0.3L/min, and the scanning time is 120s. The deposition rate of dimethylnaphthalene in human respiratory tract is 11%.
Example 8
The difference from example 1 is that: the energy level E/N value of the drift tube in the parameter setting of the embodiment is 110TD. The detection result shows that when the particle detection is carried out by selecting 300-400 nm, the thermal desorption temperature of an aerosol chemical component on-line real-time analysis sample injection system is regulated to 120 ℃, the energy level E/N value of a drift tube is 110TD, the sheath gas flow rate of a scanning electromigration particle size spectrometer is 3L/min, the sampling flow rate is 0.3L/min, and the scanning time is 180s. The deposition rate of dimethylnaphthalene in human respiratory tract is 9.6%.
The present invention is not limited by the above embodiments, and the above embodiments and descriptions are merely illustrative of the basic principles, main features and advantages of the present disclosure, and various changes and modifications may be made therein without departing from the spirit and scope of the disclosure, which is within the scope of the disclosure as claimed.
Claims (8)
1. The method for measuring the deposition rate of volatile organic compounds in the atmospheric particulates in the respiratory tract of a human body is characterized by comprising the following steps of:
S1, collecting human exhaled air by using a Teflon sampling bag, screening the particle size of exhaled air particles by using a scanning electromigration particle size spectrometer, and detecting the composition and concentration of volatile organic compounds with various proton affinities greater than water on the particles in the human exhaled air by combining a real-time analysis sample injection system with a proton transfer reaction flight time mass spectrometer;
S2, directly screening and detecting the particle size of the environmental atmospheric particulates where the crowd is located by using a scanning electromigration particle size spectrometer, and detecting the composition and concentration of volatile organic compounds with various proton affinities greater than water on the atmospheric environmental particulates by using an aerosol chemical composition real-time analysis sample injection system combined with a proton transfer reaction flight time mass spectrometer;
S3, comparing the concentration difference of various volatile organic compounds on the exhaled air of the human body and the ambient air particulate matters in the step S1 and the step S2, and selecting the volatile organic compound data with the concentration of the volatile organic compounds on the ambient air particulate matters higher than the concentration of the corresponding exhaled air particulate matters of the human body as deposition matters on the respiratory tract of the human body;
S4, subtracting the concentration level of volatile organic matters with various proton affinities larger than water from the concentration level of volatile organic matters with various proton affinities larger than water on the particles exhaled by the human body, and dividing the difference by the concentration level of various volatile organic matters in the atmospheric particles to obtain the deposition rate of various volatile organic matters with various proton affinities larger than water in the atmospheric particles with different particle diameters in the respiratory tract of the human body.
2. The method for measuring the deposition rate of volatile organic compounds in the atmospheric particulates on the respiratory tract of a human body according to claim 1, wherein the exhaled breath of the human body in step S1 is obtained by filling a teflon sampling bag with the human body through a disposable mouthpiece.
3. The method for measuring the deposition rate of volatile organic compounds in the air particulate matters in the respiratory tract of a human body according to claim 1, wherein the parameters of the scanning electromigration particle size spectrometer in the steps S1 and S2 are set as follows: the sheath gas flow rate is 3-15L/min, the sampling flow rate is 0.3-1.5L/min, and the scanning time is 30-500S, so that the differential electromigration rate analyzer in the scanning electromigration particle size spectrometer in the steps S1 and S2 screens out the particles in the target particle size section at 10-1000 nm for counting and detection.
4. The method for measuring the deposition rate of volatile organic compounds in the atmospheric particulates on the respiratory tract of a human body according to claim 1, wherein the parameters of the aerosol chemical component real-time analysis sample injection system in steps S1 and S2 are set as follows: the thermal desorption temperature is 50-200 ℃, and the energy level E/N value of the drift tube is 60-150 TD.
5. The method for measuring the deposition rate of volatile organic compounds in the atmospheric particulates on the respiratory tract of a human body according to claim 1, wherein the volatile organic compounds with the proton affinity larger than that of water in the steps S1 to S4 are more than one of formaldehyde, toluene, acetaldehyde, acetonitrile, acetone, quinoline and dimethylnaphthalene.
6. The method for measuring the deposition rate of volatile organic compounds in the atmospheric particulates in the respiratory tract of a human body according to claim 1, wherein the specific detection method for the composition and the concentration of each volatile organic compound in the steps S1 and S2 is as follows: the fluorine dragon sampling bag is connected to a particle filter through one end of a three-way valve, the other end of the fluorine dragon sampling bag is connected to a drying pipe, then particles with different particle size sections are screened out by an electrostatic classifier and a differential electric mobility analyzer, then 1 three-way valve is connected to enable one part of gas to enter a condensation nucleus particle counter for counting, the other part of gas enters an aerosol chemical component real-time analysis sampling system, organic gas is efficiently adsorbed by a gas phase filter and particles are conveyed, then the particles are enriched by an aerodynamic lens, then organic components in the particles are volatilized to a gas phase by a thermal analyzer, and finally volatile organic matters are detected by a proton transfer reaction time-of-flight mass spectrum through a soft ionization mode by using H 3O+.
7. A system for realizing the method for measuring the deposition rate of volatile organic compounds in the atmospheric particulates in the respiratory tract of a human body according to any one of claims 1 to 6, which is characterized in that the system comprises a teflon sampling bag, an aerosol chemical component real-time analysis sampling system, a proton transfer reaction time-of-flight mass spectrometer, a scanning electromobility particulate particle size spectrometer, a single tube dryer and a high-efficiency particulate air capsule filter; the real-time online analysis and sample injection system for the chemical components of the aerosol comprises a gas phase filter, an aerodynamic lens and a thermal desorption device; the proton transfer reaction time-of-flight mass spectrum comprises an ion source, a drift tube, a mass analyzer and an ion detector; the scanning electric mobility particle size spectrometer comprises an electrostatic classifier, a differential electric mobility analyzer and a condensation nucleus particle counter. The Teflon sampling bag is connected to a particle filter through one end of a three-way valve, the other end of the Teflon sampling bag is connected to a drying pipe, then particles with different particle size sections are screened out by an electrostatic classifier and a differential electric mobility analyzer, then a three-way valve is connected to enable a part of gas to enter a condensation nuclear particle counter for counting, a part of gas enters an aerosol chemical composition real-time analysis sampling system, organic gas is efficiently adsorbed by a gas phase filter and the particles are conveyed, then the particles are enriched by an aerodynamic lens, then organic components in the particles are volatilized to a gas phase by a thermal analyzer, and finally volatile organic matters are detected through proton transfer reaction time-of-flight mass spectrometry.
8. Use of the method for measuring the deposition rate of volatile organic compounds in atmospheric particulates according to any one of claims 1 to 6 in the field of environmental exposure evaluation.
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