CN117919963B - Asymmetric hydrophobic and hydrophilic directional self-pumping functional polymer porous membrane and preparation method thereof - Google Patents
Asymmetric hydrophobic and hydrophilic directional self-pumping functional polymer porous membrane and preparation method thereof Download PDFInfo
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0079—Manufacture of membranes comprising organic and inorganic components
- B01D67/00791—Different components in separate layers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/39—Electrospinning
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01D2325/39—Amphiphilic membranes
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
The invention belongs to the field of membrane separation, and relates to an asymmetric hydrophobic and hydrophilic directional self-pumping functional polymer porous membrane and a preparation method thereof. According to the invention, the hydrophobic layer with a porous structure is prepared by regulating and controlling the proportion of the mixed solvent of chloroform and dimethyl sulfoxide and utilizing a phase separation method, so that the rapid release of the fat-soluble drug curcumin is effectively promoted, and the oxidation resistance is remarkably enhanced. Meanwhile, the modified PAN-SiO 2 film and the polylactic acid-based hydrophobic layer with a porous structure are compounded, so that the unidirectional liquid guiding capability of the polymer porous film is obviously improved, and finally, the hydrophilic layer containing the purple cabbage anthocyanin is loaded on the other side of the modified PAN-SiO 2 film, so that the modified PAN-SiO 2 film has good unidirectional liquid guiding characteristics, can intuitively respond to a wound healing state, can timely separate exuded liquid from a body surface, and prevents excessive hydration of a wound, thereby accelerating the wound healing process. The invention solves the problems that the existing polymer porous membrane has insufficient membrane separation capability and can not separate exuded liquid from the body surface in time.
Description
Technical Field
The invention belongs to the field of membrane separation, and particularly relates to an asymmetric hydrophobic and hydrophilic directional self-pumping functional polymer porous membrane and a preparation method thereof.
Background
The disclosure of this background section is only intended to increase the understanding of the general background of the invention and is not necessarily to be construed as an admission or any form of suggestion that this information forms the prior art already known to those of ordinary skill in the art.
The nanofiber membrane prepared by the electrostatic spinning technology has excellent properties such as large aperture ratio, good hygroscopicity and high porosity. In clinic, the electrostatic spinning nanofiber membrane treated by drug loading can be used for treating burn wounds and moderately severe liquid seepage wounds. However, the current electrospun nanofiber membranes have limited and cannot maintain liquid absorption capacity, and it is difficult to separate exuded liquid from the body surface in time.
Electrospun hydrophilic nanofibers have a large number of pores, facilitate rapid diffusion of liquid thereon, thereby facilitating the absorption of wound exudate, and are particularly promising biomedical materials due to their high specific surface area and extracellular matrix-like structure. Janus materials with asymmetric wettability (two materials of different properties separated on the same object) have gained increasing attention due to their unique liquid transport capacity, the so-called fluid diode effect. The synergistic combination of asymmetric wettability and different pore sizes across the thickness of the biomimetic bilayer or multilayer fabric ensures the directional transport of water spontaneously from the hydrophobic side to the hydrophilic side. The porous nanofibers have a diameter similar to the diameter of collagen fibers in the natural extracellular matrix (ECM) and a high surface area that also increases tissue interactions, allowing the drug to be released in a sustained manner, and also helping to regulate cell function. However, at present, the electrostatic spinning nanofiber membrane is difficult to separate exuded liquid from the body surface in time, and the membrane separation capability still needs to be enhanced.
Disclosure of Invention
In order to solve the problems, the invention provides an asymmetric hydrophobic and hydrophilic self-pump functional polymer porous membrane and a preparation method thereof. According to the invention, the hydrophobic layer with a porous structure is prepared by regulating and controlling the proportion of the mixed solvent of Chloroform (CF) and dimethyl sulfoxide (DMSO) through a phase separation method, so that the rapid release of the liposoluble medicament curcumin is effectively promoted, and the oxidation resistance is remarkably enhanced. The study of the invention also found that: the modified PAN (polyacrylonitrile) -SiO 2 (silicon dioxide) film is compounded with the polylactic acid-based hydrophobic layer with the porous structure, so that the unidirectional liquid guiding capacity of the polymer porous film is remarkably improved, and exudation liquid can be timely separated from the body surface.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
In a first aspect of the present invention, there is provided a method for preparing an asymmetric hydrophobic and hydrophilic self-pump functional polymeric porous membrane comprising:
dissolving polylactic acid (PLA) and curcumin (Cur) in a solvent to prepare a hydrophobic side electrostatic spinning solution;
Dispersing SiO 2 nano particles in N, N-Dimethylformamide (DMF) to obtain a SiO 2/DMF dispersion solution;
dissolving polyacrylonitrile in the SiO 2/DMF dispersion solution to prepare a transfer layer spinning solution;
Dissolving polyacrylonitrile in DMF to obtain a polyacrylonitrile electrostatic spinning solution, and then adding a Purple Cabbage Anthocyanin (PCA) solution to obtain a hydrophilic side electrostatic spinning solution;
Preparing a non-modified transfer layer spinning film by adopting a transfer layer spinning solution, and then performing alkaline hydrolysis to obtain a modified transfer layer; and loading a hydrophilic layer on one side of the modified transfer layer by adopting the hydrophilic side electrostatic spinning solution, and loading a hydrophobic layer on the other side of the modified transfer layer by adopting the hydrophobic side electrostatic spinning solution.
Further, the concentration of the polylactic acid is 14% w/v.
Further, the concentration of curcumin in the hydrophobic side electrostatic spinning solution is 0.1-0.2% w/v.
Further, the solvent is a mixed solvent of chloroform and dimethyl sulfoxide, and the volume ratio of the chloroform to the dimethyl sulfoxide is 8:2.
Further, in the SiO 2/DMF dispersion solution, the mass concentration of SiO 2 nano particles is 0.02g/mL.
Further, in the transfer layer spinning dope, the mass ratio of polyacrylonitrile to SiO 2 nano particles is 8:1.
Further, the mass concentration of the polyacrylonitrile electrostatic spinning solution is 10%.
Further, in the hydrophilic side electrostatic spinning solution, the mass concentration of the purple cabbage anthocyanin is 2% -4%.
Further, the electrostatic spinning condition of the hydrophobic layer is that spinning is carried out for 15min under the voltage of 16 kV; the electrostatic spinning condition of the transfer layer is that spinning is carried out for 2 hours under the voltage of 16 kV; and the electrostatic spinning condition of the hydrophilic layer is that the hydrophilic layer is spun for 4 hours under 20kV voltage.
In a second aspect of the present invention, there is provided an asymmetric hydrophobic and hydrophilic self-pumping functional polymeric porous membrane prepared by the method described above.
The beneficial effects of the invention are that
(1) The invention enables the porous membrane to characterize the pH value of the exudates while having self-pumping performance by reasonably designing the composition of the three layers of the hydrophobic layer, the transfer layer and the hydrophilic layer, thereby enabling a user to judge the wound healing process in time. The hydrophobic layer with a porous structure is prepared by a phase separation method by regulating and controlling the proportion of the mixed solvent of chloroform and dimethyl sulfoxide, so that the quick release of the liposoluble medicament curcumin is effectively promoted, and the oxidation resistance is obviously enhanced. The invention also compounds the modified PAN-SiO 2 film (polyacrylonitrile-silicon dioxide film) with the polylactic acid-based hydrophobic layer with a porous structure, thereby remarkably improving the unidirectional liquid guiding capability of the polymer porous film and being capable of timely separating exuded liquid from the body surface.
(2) The self-pumping capacity provided by the invention is based on the comprehensive effect of the Laplace pressure and the capillary force, and the controllable adjustment of the liquid movement direction can be realized simply and controllably by changing the contact angle of the membrane. By changing the spinning time of the hydrophobic layer, janus composite films with different liquid guiding speeds can be prepared for various occasions.
(3) The Janus nanofiber membrane obtained by the electrostatic spinning process has the advantages of large porosity, large surface body ratio, light weight, strong drug loading capacity and the like.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention.
FIG. 1 is a schematic diagram of the preparation and application of a porous polymer membrane of the present invention.
Fig. 2 is a Scanning Electron Microscope (SEM) image of the three-layer film prepared in example 1 of the present invention, wherein (a), (b), (c), (d), (e), (f), (g), (h) are SEM images of the three-layer film at different positions.
FIG. 3 shows the contact angle test results of modified transfer films with different alkali treatment times in example 3 of the present invention.
FIG. 4 shows the breakthrough water column height of the hydrophobic layer at different spinning times in example 4 of the present invention.
Fig. 5 is a drug release performance and antioxidant performance test: (a) Drug release performance curves of porous and non-porous fibrous membranes loaded with different amounts of curcumin; (b) Porous and non-porous fibrous membranes loaded with different amounts of curcumin have oxidation resistance.
FIG. 6 is a representation of a composite film: (a) SEM images of 4% anthocyanin-loaded fibers (hydrophilic layer); (b) Ultraviolet absorption peaks of anthocyanin standard solution in buffer solutions with different pH values.
Fig. 7 shows infrared absorption peaks of PAN film (PAN), anthocyanin (PCA) and PAN film loaded with anthocyanin (pan@pca).
Figure 8 shows four forms of anthocyanin in different pH environments.
Fig. 9 is a graph of color development behavior of a composite film: (a) Lab values of fiber membranes loaded with 2% anthocyanin in buffers with different pH values; (b) Lab values of 4% anthocyanin-loaded fiber membranes in buffers of different pH values.
FIG. 10 is a graph of the self-pumping capacity verification of a three-layer composite membrane liquid.
FIG. 11 is a graph showing the unidirectional liquid transport properties of the porous polymer membrane prepared in example 1 of the present invention.
Detailed Description
It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
The invention will now be described in further detail with reference to the following specific examples, which should be construed as illustrative rather than limiting.
In the following examples, the extraction of anthocyanin included: 150g of the crushed purple cabbage is immersed in 80mL of an ethanol/water solution (volume ratio of ethanol to water: 7:3). Then, an appropriate amount of 1M HCl solution was added, and the pH of the mixture was adjusted to 2. The mixture was then stored in a refrigerator at 5 ℃ for 24 hours, followed by filtration. The extract was centrifuged at 2000rpm for 10min, and the supernatant was filtered through a filter paper (No. 1 qualitative filter paper, pore size: 11 μm). Finally, the pH value of the obtained purple cabbage anthocyanin solution is adjusted to 6 by adding a proper amount of 2.5M NaOH solution. It should be mentioned that there is no further purification of the purple cabbage anthocyanin solution, and therefore, various by-products (such as sugars, sugar alcohols, organic acids, amino acids and proteins) are present in the solution in addition to the anthocyanin.
Example 1
The preparation method of the asymmetric hydrophobic and hydrophilic self-pump oriented functional polymer porous membrane comprises the following steps (the preparation flow is shown in figure 1):
(1) As for the hydrophobic layer, PLA with a concentration of 14% w/v was dissolved in a mixed solvent of CF and DMSO and stirred at 25℃for 8 hours to obtain a uniform electrospinning solution. Wherein, the volume ratio of CF to DMSO is selected to be 8:2, and packaging curcumin. The required Cur (0.1%, 0.2%, in mass concentration) was added to the selected electrospinning solution (25 ℃,60% RH), respectively, and the corresponding porous fibrous membranes were designated PCPLA-0.1 and PCPLA-0.2.
(2) For the transfer layer, 0.8g of SiO 2 nanoparticles (average diameter 80 nm) were added to 40mL of DMF and vigorously stirred with a magnetic stirrer when a PAN-SiO 2 solution was prepared. Then ultrasonic dispersing for 1h, ensuring that SiO 2 nano particles are uniformly dispersed. Finally, PAN powder (6.4 g) was added to the corresponding SiO 2/DMF dispersion solution with continuous stirring to ensure complete dissolution of the polymer. The thickness of the PAN-SiO 2 film of the transfer layer is controlled to be about 80 mu m by adjusting the spinning time. The process conditions include: injecting the spinning solution into a 10mL injector, fixing the injector on a microinjection pump, wherein the relative humidity of the electrostatic spinning process is 60+/-10% RH, the environment temperature is 25+/-2 ℃, the spinning is carried out for 2 hours under 16kV voltage, the pushing speed is 2mL/h, a roller collector is used as a receiving device, the rotating speed is 60rpm, and the fibrous membrane is collected on an aluminum foil so as to enhance the conductivity in the spinning process.
(3) For the hydrophilic layer, a uniform electrospinning solution (mass concentration of polyacrylonitrile is 10%) was obtained by dissolving PAN in 20mL of DMF and stirring at 25 ℃ for 12 hours. Subsequently, the desired purple cabbage anthocyanins (2% and 4% by mass concentration) are added to the selected solutions for electrospinning, respectively, the corresponding films being labeled pan@pca-2 and pan@pca-4, respectively.
(4) For the polymer porous membrane, preparing a non-modified transfer layer spinning membrane according to the condition of the step (2), and then hydrolyzing by alkali treatment, wherein the technological conditions comprise: immersing a transfer layer PAN-SiO 2 film in 2moL/L NaOH solution (the solvent is composed of ethanol and deionized water in a volume ratio of 7:3), hydrolyzing for 30min at 50 ℃, then washing the obtained film with distilled water until the pH value is neutral, finally drying in a natural state to obtain a modified transfer layer, and then carrying out electrostatic spinning on a PAN hydrophilic layer loaded with PCAs to one side, wherein the process conditions comprise: injecting the spinning solution into a 10mL injector, fixing the injector on a microinjection pump, wherein the humidity is in a natural state, the ambient temperature is 25+/-2 ℃, the voltage of electrostatic spinning is 20kV, the flow rate is 1mL/h, the spinning time is 4h, the distance between a needle point and a collector is 15cm, a roller collector is used as a receiving device, the rotating speed is 60rpm, and a fiber film is collected on an aluminum foil so as to enhance the conductivity in the spinning process; finally, depositing a PLA hydrophobic layer loaded with curcumin on the other side of the modified transfer layer, wherein the technological conditions comprise: injecting the spinning solution into a 10mL injector, fixing the injector on a microinjection pump, wherein the relative humidity is 60+/-10% RH, the ambient temperature is 25+/-2 ℃, a 21-grade stainless steel needle is adopted for electrostatic spinning, the voltage is 16kV, the flow rate is 4mL/h, the spinning is carried out for 15min, the distance between a needle tip and a collector is 15cm, a roller collector is adopted as a receiving device, the rotating speed is 60rpm, and a fibrous membrane is collected on an aluminum foil so as to enhance the conductivity in the spinning process; and obtaining the well-combined three-layer composite film.
Example 2
The difference from example 1 is that for the hydrophobic layer, a volume ratio of CF to DMSO of 9 is chosen: 1, and packaging curcumin. The selected electrospinning solutions (25 ℃,60% rh) were added with the required Cur (0.1%, 0.2%), respectively, and the corresponding non-porous fibrous films (single-layer films) were designated as CPLA-0.1 and CPLA-0.2.
Example 3
The hydrolysis and wettability of the PAN-SiO 2 film of example 1 was tested as follows: immersing the transfer layer PAN-SiO 2 film in 2moL/L NaOH solution (the volume ratio of ethanol to deionized water in the solvent is 7:3), hydrolyzing at 50deg.C for different times (0 min, 15min, 30min, 45min and 60 min), washing the obtained film with distilled water until pH is neutral, and drying in natural state. The single-layer hydrolyzed PAN-SiO 2 fiber membranes (recorded as HPAN) subjected to different alkali treatment times were recorded as 0min, 15min, 30min, 45min and 60min, respectively.
The water contact angle of the above single-layer hydrolyzed PAN-SiO 2 fiber film was measured using a contact angle tester. First, a sample was placed on the same stainless steel sheet, then placed on a workbench, 10 μl of deionized water was added dropwise to the surface of the sample, and the dynamic change process of the contact angle was recorded using screen software, and the test results are shown in fig. 3.
Example 4
The difference from example 1 is that the spinning time of the hydrophobic layer was 4min,6min,8min, respectively, to prepare a double-layer film composed of the hydrophobic layer and the modified transfer layer Janus film, designated as PPLA-4, PPLA-6, PPLA-8.
The above-mentioned double-layer film breakthrough pressure was tested. The breakthrough pressure of the membrane is characterized by measuring the height of a water column which can be borne by the double-layer membrane, and the testing device consists of two micro-filter cups with 15mL specifications which are connected in a reverse way.
The test results are shown in fig. 4, wherein the height of the breakthrough water column from the hydrophilic side to the hydrophobic side of the double-layer film is higher, and the height of the breakthrough water column from the hydrophobic side to the hydrophilic side of the double-layer film is lower.
Example 5
The composite fiber type porous membrane obtained in example 1 was subjected to curcumin release performance test, 10mg of CPLA-0.1, CPLA-0.2, PCPLA-0.1 and PCPLA-0.2 single-layer membranes were immersed in a 100mL flask containing 50mL of a mixed solution (the volume ratio of ethanol to phosphate buffer in the solvent was 3:7 as a simulated permeate), and then subjected to Cur release test at a constant temperature of 37 ℃. After measurement of the ultraviolet spectrophotometry at 426nm, the solution to be measured was immediately poured back to ensure that the total volume was unchanged.
Antioxidant activity of PLA nanofiber membranes loaded with different mass fractions Cur was examined using a2, 2-diphenyl-1-trinitro-hydrazino hydrate (DPPH) radical assay. The antioxidant activity of the hydrophobic layer was determined by its ability to scavenge 1, 1-diphenyl-2-picrylhydrazyl radicals. 10mg of the samples were treated briefly with 40mg/mL DPPH ethanol solution at 25℃in the dark for different times (0.5 h, 1h, 1.5h, 2 h), the control group being the same DPPH solution without the sample. The absorbance of the solution was measured at 517nm using an ultraviolet spectrophotometer (UV-1900i, SHIMADZU, japan). DPPH radical scavenging activity (DPPHRSA) can be calculated by the following formula:
Wherein A 0 is the absorbance of the control group, and A 1 is the absorbance of the reaction group. Antioxidant capacity of samples loaded with Cur at different concentrations was evaluated by the efficiency of DPPH radical scavenging.
As shown in figure 5, the hydrophobic layer with the porous structure prepared by the phase separation method effectively promotes the rapid release of the fat-soluble drug curcumin, and the oxidation resistance is obviously enhanced.
Example 6
The three-layer composite film obtained in example 1 was subjected to color development behavior of a colorimetric film and self-pumping performance detection of the composite film. For early-stage diabetic wounds, the pH value of wound exudate is obviously increased from acidity (pH value is 4-6) to alkalinity (pH value is 7.5-9.0). In contrast, the basic diabetic wound gradually becomes neutral in the healing process, and finally returns to the normal acidic state. Therefore, the pH value of wound exudate can be used as an important index for monitoring the healing process of the diabetic wound. When the anthocyanin molecules interact with the outside, H + (hydrogen ions) or OH − (hydroxyl ions) can induce the change of pigment structures (protonation or phenol oxygen ions) to change the distribution state of pi electrons in the molecular structures, and the absorption and reflection of light can be changed, so that the anthocyanin is induced to take on different colors, as shown in fig. 6-10.
In order to verify the liquid self-pumping capability of the three-layer composite membrane, two membranes with similar sizes are placed on filter paper in opposite directions, 1 drop and two drops with the pH value of=6 are respectively dripped, when the drops are dripped from the hydrophobic side to the hydrophilic side, the drops permeate the filter paper, the reversely dripped drops are blocked on the hydrophilic side and cannot penetrate the hydrophobic side to reach the filter paper, and the unidirectional liquid guiding capability is stronger, and the liquid guiding time is only 15s, as shown in fig. 11.
Therefore, the invention utilizes the anti-inflammatory and antioxidant properties of curcumin to pertinently treat chronic wounds, characterizes the physicochemical environment of the wounds by virtue of anthocyanin preparation, and can promote the rapid release of the liposoluble drug curcumin by utilizing the nanometer internal porous structure of the hydrophobic layer, thereby removing excessive free radicals on the surfaces of the wounds in the healing process and inhibiting bacterial proliferation. When the wound is brought from an acidic pH to a basic pH, one of the two phenol groups is deprotonated to form a phenoxy ion and then the resonance is stabilized by electron redistribution to form a ketone. The thickness of each layer of film is controlled by controlling the electrostatic spinning time, so that the wound healing device has good unidirectional liquid guiding characteristics, can intuitively respond to the wound healing state, can timely separate exudation liquid from the body surface, and prevents the wound from being overhydrated, thereby accelerating the wound healing process and avoiding further deterioration. In-vitro and in-vivo experiments show that the multifunctional composite porous membrane has the characteristic of improving the comprehensive performance compared with the traditional polymer membrane, and has strong application potential. The invention can efficiently prepare the polymer porous membrane which has excellent anti-inflammatory and oxidation resistance, is green, nontoxic and biodegradable, and can relieve the problem of environmental pollution caused by burning medical wastes to a certain extent.
The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. A method for preparing an asymmetric hydrophobic and hydrophilic self-pump functional polymer porous membrane, which is characterized by comprising the following steps:
dissolving polylactic acid and curcumin in a mixed solvent to prepare a hydrophobic side electrostatic spinning solution;
dispersing SiO 2 nano-particles in DMF to obtain SiO 2/DMF dispersion solution;
dissolving polyacrylonitrile in the SiO 2/DMF dispersion solution to prepare a transfer layer spinning solution;
Dissolving polyacrylonitrile in DMF to obtain a polyacrylonitrile electrostatic spinning solution, and then adding a purple cabbage anthocyanin solution to obtain a hydrophilic side electrostatic spinning solution;
Preparing a non-modified transfer layer spinning film by adopting the transfer layer spinning solution, and then performing alkali hydrolysis to obtain a modified transfer layer; loading a hydrophilic layer on one side of the modified transfer layer by adopting the hydrophilic side electrostatic spinning solution, and loading a hydrophobic layer on the other side of the modified transfer layer by adopting the hydrophobic side electrostatic spinning solution to obtain the modified transfer layer;
The mixed solvent is a mixed solvent of chloroform and dimethyl sulfoxide, and the volume ratio of the chloroform to the dimethyl sulfoxide is 8:2;
The electrostatic spinning condition of the hydrophobic layer is that spinning is carried out for 15min under the voltage of 16 kV; the electrostatic spinning condition of the transfer layer is that spinning is carried out for 2 hours under the voltage of 16 kV; and the electrostatic spinning condition of the hydrophilic layer is that the hydrophilic layer is spun for 4 hours under 20kV voltage.
2. The method of preparing an asymmetric hydrophobic and hydrophilic self-pump functional polymeric porous membrane of claim 1, wherein the polylactic acid is used in an amount of 14% w/v.
3. The method of preparing an asymmetric hydrophobic and hydrophilic self-priming functional polymeric porous membrane according to claim 1, wherein the concentration of curcumin in said hydrophobic side electrospinning dope is 0.1% w/v to 0.2% w/v.
4. The method for preparing the asymmetric hydrophobic and hydrophilic self-pumping functional polymer porous membrane according to claim 1, wherein the mass concentration of SiO 2 nano particles in the SiO 2/DMF dispersion solution is 0.02g/mL.
5. The method for preparing the asymmetric hydrophobic and hydrophilic self-pumping functional polymer porous membrane according to claim 1, wherein the mass ratio of polyacrylonitrile to SiO 2 nano-particles in the transfer layer spinning solution is 8:1.
6. The method for preparing an asymmetric hydrophobic and hydrophilic self-pump functional polymer porous membrane according to claim 1, wherein the mass concentration of the polyacrylonitrile electrospinning solution is 10%.
7. The method for preparing the asymmetric hydrophobic and hydrophilic self-pumping functional polymer porous membrane according to claim 1, wherein the mass concentration of the purple cabbage anthocyanin in the hydrophilic side electrostatic spinning solution is 2-4%.
8. An asymmetric hydrophobic and hydrophilic self-pumping functional polymeric porous membrane prepared by the method of any one of claims 1-7.
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| CN113502605A (en) * | 2021-08-05 | 2021-10-15 | 上海工程技术大学 | Multilayer fiber membrane with oriented water transmission function and preparation method thereof |
| CN116459381A (en) * | 2023-04-04 | 2023-07-21 | 山东大学 | PH-sensitive type chronic wound medical dressing with unidirectional liquid guiding function and preparation method thereof |
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| JP2007154335A (en) * | 2005-12-01 | 2007-06-21 | Snt Co | Water-repellent membrane, method for producing water-repellent membrane, method for forming water-repellent membrane on surface of article, and article obtained by the method |
| CN102475891A (en) * | 2010-11-23 | 2012-05-30 | 中国科学院化学研究所 | PH-responsive polyethylene glycol-anticarcinogen conjugate, and synthetic method and application thereof |
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| CN113502605A (en) * | 2021-08-05 | 2021-10-15 | 上海工程技术大学 | Multilayer fiber membrane with oriented water transmission function and preparation method thereof |
| CN116459381A (en) * | 2023-04-04 | 2023-07-21 | 山东大学 | PH-sensitive type chronic wound medical dressing with unidirectional liquid guiding function and preparation method thereof |
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