CN117881407A - 靶向trop-2阳性癌症的嵌合抗原受体 - Google Patents

靶向trop-2阳性癌症的嵌合抗原受体 Download PDF

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Publication number
CN117881407A
CN117881407A CN202280059099.5A CN202280059099A CN117881407A CN 117881407 A CN117881407 A CN 117881407A CN 202280059099 A CN202280059099 A CN 202280059099A CN 117881407 A CN117881407 A CN 117881407A
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polynucleotide
cell
cells
seq
trop
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Chinese (zh)
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K·雷兹瓦尼
S·阿查亚
F·美力克-伯纳黛特
N·尤普赖特瑞
R·巴萨尔
D·马林科斯达
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University of Texas System
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University of Texas System
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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CN202280059099.5A 2021-07-09 2022-07-08 靶向trop-2阳性癌症的嵌合抗原受体 Pending CN117881407A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163220283P 2021-07-09 2021-07-09
US63/220,283 2021-07-09
PCT/US2022/073566 WO2023283644A2 (en) 2021-07-09 2022-07-08 Chimeric antigen receptor to target trop-2-positive cancers

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CN117881407A true CN117881407A (zh) 2024-04-12

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CN202280059099.5A Pending CN117881407A (zh) 2021-07-09 2022-07-08 靶向trop-2阳性癌症的嵌合抗原受体

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US (1) US20240325444A1 (https=)
EP (1) EP4366747A4 (https=)
JP (1) JP2024525609A (https=)
KR (1) KR20240034220A (https=)
CN (1) CN117881407A (https=)
AU (1) AU2022306051A1 (https=)
CA (1) CA3224887A1 (https=)
IL (1) IL309497A (https=)
MX (1) MX2024000479A (https=)
WO (1) WO2023283644A2 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN118307680A (zh) * 2024-04-28 2024-07-09 华南农业大学 一种抗氯霉素单克隆抗体及其基于磁珠的自动化化学发光酶免疫检测方法与应用

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CN118265535A (zh) * 2021-10-20 2024-06-28 得克萨斯大学体系董事会 具有最佳信号传导的car构建体的工程化nk细胞
GB202318553D0 (en) * 2023-12-05 2024-01-17 Unikum Therapeutics Aps Engineered plasmacytoid dendritic cells
WO2025194098A1 (en) * 2024-03-14 2025-09-18 Dana-Farber Cancer Institute, Inc. Engineered immune cells expressing chimeric antigen receptors targeting trop2, and methods of using the same
CN119215188B (zh) * 2024-04-12 2025-09-05 英百瑞(杭州)生物医药有限公司 抗Trop2抗体和抗5T4抗体-自然杀伤细胞偶联物及其用途

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WO2003074566A2 (en) * 2002-03-01 2003-09-12 Immunomedics, Inc. Rs7 antibodies
JP2018500930A (ja) * 2014-12-04 2018-01-18 アブルッツォ・セラノスティックス・エッセ・エッレ・エッレ ヒト化抗ｔｒｏｐ−２モノクローナル抗体及びその使用
CN107708741A (zh) * 2015-06-12 2018-02-16 免疫医疗公司 用嵌合抗原受体(car)构建体和表达car构建体的t细胞(car‑t)或nk细胞(car‑nk)进行的疾病疗法
US11951131B2 (en) * 2018-07-03 2024-04-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-SLAMF7 chimeric antigen receptors
BR112021003640A2 (pt) * 2018-08-31 2021-05-18 Noile-Immune Biotech, Inc. célula t, medicamento, vetor de expressão, e, métodos para produzir uma célula de t car e para tratar câncer
SG11202104524YA (en) * 2018-11-01 2021-05-28 Gracell Biotechnologies Shanghai Co Ltd Compositions and methods for t cell engineering
WO2023232746A1 (en) * 2022-05-30 2023-12-07 Mediterranea Theranostic S.R.L. Anti-activated trop-2 chimeric antigen receptor constructs for use in cancer therapy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118307680A (zh) * 2024-04-28 2024-07-09 华南农业大学 一种抗氯霉素单克隆抗体及其基于磁珠的自动化化学发光酶免疫检测方法与应用

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IL309497A (en) 2024-02-01
US20240325444A1 (en) 2024-10-03
CA3224887A1 (en) 2023-01-12
AU2022306051A1 (en) 2024-02-08
KR20240034220A (ko) 2024-03-13
WO2023283644A3 (en) 2023-02-23
EP4366747A4 (en) 2025-11-05
MX2024000479A (es) 2024-03-27
WO2023283644A2 (en) 2023-01-12
JP2024525609A (ja) 2024-07-12
EP4366747A2 (en) 2024-05-15

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