CN117871840A - Method for detecting distilled liquor sobering-up time - Google Patents
Method for detecting distilled liquor sobering-up time Download PDFInfo
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Abstract
The invention discloses a method for detecting the sobering-up time of distilled liquor, which comprises the following steps: establishing an sobering-up time analysis model; measuring sobering-up time; statistical analysis of sobering-up time of testers: judging whether the sample data of the wine to be tested and the sample data of the pure alcohol solution have significant differences or not, and performing significant verification; respectively drawing a relationship curve of the ethanol metabolism blood concentration and time of a tester of the wine to be tested and a relationship curve of the ethanol metabolism blood concentration and time of a tester of the pure alcohol solution, and performing line type fitting; respectively obtain k Absorption of 、k Elimination of And then calculating the sobering-up time of the to-be-detected wine and the pure alcohol solution. Aiming at the problem that the prior art is difficult to quantitatively measure the alcohol intoxication degree, the invention uses the sobering-up time as the quantitative representation of the alcohol intoxication degree, and provides a quantitative detection method of the sobering-up time.
Description
Technical Field
The invention relates to a distilled liquor detection method, in particular to a distilled liquor sobering-up time detection method.
Background
As is well known, the main components of white spirit are ethanol and water, which can be mutually dissolved in any proportion. After the white spirit is drunk into the oral cavity, the white spirit can directly enter blood through esophagus membrane, stomach membrane, intestinal membrane and the like in a human body without digestion, and is metabolized in all tissues and organs of the whole body. The people can be drunk easily after drinking, and the alcohol is a metabolite acetaldehyde in the body, and some people lack acetaldehyde conversion dehydrogenase in the body and can not be converted into acetic acid to be discharged outside, so that acetaldehyde poisoning is caused, and various drunk allergic symptoms such as excitement, dry mouth after drinking, dizziness, head distention, headache, flushing, rising of blood pressure, acceleration of heartbeat and the like can be displayed.
The wine is drunk to drink the product with low alcohol content, and the wine with low alcohol content has short in-vivo retention time, namely quick metabolism and relatively small influence on the body, otherwise, the wine with high alcohol content has long in-vivo retention time, slow metabolism and relatively large influence on the body. The product with low alcohol content can be drunk comfortably, and can be awakened quickly, and the product feels fresh and natural.
The research on the alcoholic intoxication degree of the white spirit is mainly focused on animal experiments at present, and the influence of distilled spirit on the metabolism of experimental samples tends to be more prone, and the research on a certain class of substances has very little effect due to the fact that distilled spirit components are too complex.
Aiming at the continuous improvement of the requirements of consumers on healthy drinking, pleasure in drinking and comfort after drinking, the low-alcoholic strength white spirit becomes the trend of future development of the industry, but the current research on the alcoholic strength is still mainly qualitative, and the alcoholic strength of each product is difficult to quantitatively describe and measure.
Disclosure of Invention
In order to overcome the defects and shortcomings of the prior art, the invention aims to provide a method for detecting the sobering-up time of distilled liquor, and provides a novel method for quantitatively measuring the degree of drunk. The sobering-up time is used as an important apparent index of the comfort of the white spirit, is most closely related to the drunk degree, and can accurately and quantitatively represent the drunk degree.
The aim of the invention is achieved by the following technical scheme:
a method of detecting a time to sober up of distilled liquor, comprising the steps of:
s1, establishing a sobering-up time analysis model
The distilled liquor sobering-up time is defined as: after distilled liquor enters a human body, the total time of absorption and removal of the alcohol by the human body is calculated, and the removal time is calculated according to the duration of time when the blood concentration of the human body is reduced to below 15mg/100ml, and the unit is calculated according to minutes;
according to the principle of pharmacokinetics, a large amount of alcoholic beverage is drunk at one time, the absorption of ethanol follows the first-order kinetic rule, and the absorption power equation of ethanol is as follows:
wherein k is Absorption of An absorption constant for an individual;
solving this equation yields an expression reflecting the in vivo absorption of ethanol:
the elimination of ethanol in vivo is a zero order kinetic process, namely the elimination rate is a constant, and the chemical expression of the elimination of ethanol in vivo is as follows:
thus, the ethanol change in the body at time t is the superposition of the absorption and the removal, and the expression is that
Solving the equation as
The X (t) represents the content of ethanol in a human body at the moment t;
s2, measuring sobering-up time:
s21, selecting sample population, and performing wine forbidden three days before testing;
s22, referring to the concentration of the wine to be tested, preparing a pure alcohol solution with the same concentration as a control group, dividing a tester into a sample group and the control group, and respectively preparing the wine to be tested and the pure alcohol solution;
s23, the same food is matched, a tester is required to finish drinking wine at a constant speed within 30min, and timing is started at a first drinking time point;
s24, detecting the blood alcohol concentration of a tester by using an alcohol tester every 5min until the blood alcohol concentration of a tester is reduced to below 15mg/100ml, and completing the test;
s3, statistical analysis of sobering-up time of testers:
s31, judging whether the sample data of the wine to be tested and the sample data of the pure alcohol solution have significant differences, and performing significant verification;
s32, respectively drawing a relationship curve of the ethanol metabolism blood concentration and time of a tester of the wine to be tested and a relationship curve of the ethanol metabolism blood concentration and time of a tester of the pure alcohol solution, and performing model fitting; respectively obtaining k in the equation (1) corresponding to the wine to be measured Elimination of And eliminating the Y-axis intercept b of the fitting straight line; and k in equation (1) corresponding to pure alcohol solution Elimination of And eliminating the Y-axis intercept b of the fitting straight line;
according to sobering-up time= (b-15)/k Elimination of The unit is minutes;
and respectively calculating the sobering-up time of the to-be-detected wine and the pure alcohol solution.
Preferably, the sample population in step S21 is composed of 10 adults, 7 men and 3 women.
Preferably, the age of the sample population in step S21 is between 25 and 35 years.
Preferably, in step S21, the alcohol content of the sample population is uniformly distributed.
Preferably, the significance verification in step S31 is specifically:
and (3) carrying out average value test on the sobering-up time of the to-be-tested wine and the pure alcohol solution, wherein the original assumption is that the sobering-up time of the pure alcohol sample is shorter than that of the to-be-tested wine, and the alternative assumption is that the sobering-up time of the to-be-tested wine is shorter than that of the pure alcohol solution, and carrying out significance verification under the confidence level of 0.95.
Preferably, in step S22, the wine to be tested and the pure alcohol solution are respectively mixed, specifically:
according to the weight of 0.8g ethanol/kg, respectively adding the wine to be tested and the pure alcohol solution.
Compared with the prior art, the invention has the following advantages and beneficial effects:
aiming at the problem that the prior art cannot quantitatively measure the alcohol intoxication degree, the invention provides a quantitative characterization using the sobering-up time as the alcohol intoxication degree, and provides a quantitative detection method of the sobering-up time. The sobering-up time is used as an important apparent index and is most closely related to the degree of drunk. The invention provides a new method for quantitative measurement of drunk degree. The sobering time aims at the same product, and because of certain error caused by individual difference, the invention adopts a statistical concept to analyze, thereby further improving the accuracy of quantitative measurement of the invention.
Drawings
Fig. 1 is a diagram showing an alignment of a method of detecting a sobering-up time of distilled spirit according to an embodiment of the present invention.
FIG. 2 is a first order metabolism curve of a twelve mill product of liquor to be tested according to an embodiment of the present invention.
FIG. 3 is a first order metabolic profile of a pure alcohol solution according to an embodiment of the present invention.
Detailed Description
The present invention will be described in further detail with reference to examples, but embodiments of the present invention are not limited thereto.
The embodiment of the invention adopts a police breathing type alcohol concentration measuring instrument which accords with the national standard, in particular to an Alcosto A police breathing type alcohol concentration measuring instrument which is the type of detection equipment.
The sobering time in the invention means that after a tester drinks a certain amount of distilled liquor in a short time, the alcohol concentration in the blood reaches a peakValue (C) max Unit mg/100 ml), until the blood alcohol concentration is reduced to below 15mg/100ml, for a duration of time, designated as T Elimination of The method comprises the steps of carrying out a first treatment on the surface of the The unit is min.
The timing end point of the invention is determined that the blood alcohol concentration is reduced to below 15mg/100ml, mainly because the alcohol concentration in human blood measured by a respiration method is a regression representation of the observed value of physical quantity, and the influence factor is mainly the reproducibility of the standard calibration curve of the detection equipment. The respiratory determinator provided by the invention is authenticated by a third-party inspection agency, and accords with the national relevant product quality standard. Meanwhile, according to the regulations in the ' blood and expiration alcohol content threshold value and test of vehicle drivers ' issued by the national quality supervision and inspection and quarantine bureau ', drunk driving refers to driving behaviors that the alcohol content in the blood of the vehicle drivers is more than or equal to 20mg/100ml and less than 80mg/100 ml. In view of enhancing the effectiveness of sobering-up time, systematic errors of a respiratory detector are avoided, and particularly, the detection end point is set to be that the observed value of the blood alcohol concentration of the respiratory method is reduced to below 15mg/100 ml.
Examples
The invention discloses a method for detecting the sobering-up time of distilled liquor, which comprises the following steps:
s1, establishing a sobering-up time analysis model
The distilled liquor sobering-up time is defined as: after distilled liquor enters a human body, the total time of absorption and removal of the alcohol by the human body is calculated, and the removal time is calculated according to the duration of time when the blood concentration of the human body is reduced to below 15mg/100ml, and the unit is calculated according to minutes;
according to the principle of pharmacokinetics, a large amount of alcoholic beverage is drunk at one time, the absorption of ethanol follows the first-order kinetic rule, and the absorption power equation of ethanol is as follows:
wherein k is Absorption of An absorption constant for an individual;
solving this equation yields an expression reflecting the in vivo absorption of ethanol:
the elimination of ethanol in vivo is a zero order kinetic process, namely the elimination rate is a constant, and the chemical expression of the elimination of ethanol in vivo is as follows:
thus, the ethanol change in the body at time t is the superposition of the absorption and the removal, and the expression is that
Solving the equation as
The content of ethanol in human body at t moment is represented;
s2, measuring sobering-up time:
s21, selecting sample population, and performing wine forbidden three days before testing;
s22, referring to the concentration of the wine to be tested, preparing a pure alcohol solution with the same concentration as a control group, dividing a tester into a sample group and the control group, and respectively preparing the wine to be tested and the pure alcohol solution;
s23, the same food is matched, a tester is required to finish drinking wine at a constant speed within 30min, and timing is started at a first drinking time point;
s24, detecting the blood alcohol concentration of a tester by using an alcohol tester every 5min until the blood alcohol concentration of a tester is reduced to below 15mg/100ml, and completing the test;
s3, statistical analysis of sobering-up time of testers:
s31, judging whether the sample data of the wine to be tested and the sample data of the pure alcohol solution have significant differences, and performing significant verification;
s32, respectively drawing the alcohol metabolism blood concentration of the testers of the wine to be testedPerforming profile fitting on the relationship curve of the degree and time and the relationship curve of the alcohol metabolism blood concentration and time of a tester of the pure alcohol solution; respectively obtaining k in the equation (1) corresponding to the wine to be measured Absorption of 、k Elimination of And k in equation (1) corresponding to pure alcohol solution Absorption of 、k Elimination of ；
Respectively obtaining k in the equation (1) corresponding to the wine to be measured Elimination of And eliminating the Y-axis intercept b of the fitting straight line; and k in equation (1) corresponding to pure alcohol solution Elimination of And eliminating the Y-axis intercept b of the fitting straight line;
according to sobering-up time= (b-15)/k Elimination of The unit is minutes;
and respectively calculating the sobering-up time of the to-be-detected wine and the pure alcohol solution.
In one embodiment of the invention, the specific implementation manner of establishing the sobering-up time analysis model is as follows:
the absorption rate constant and the degradation rate constant of the sample population to the wine can be determined through experiments, so that the influence of the human body specificity difference on experimental results is solved, and the change curve of the in-vivo ethanol concentration of the individual at any moment is calculated according to the model.
According to the principle of pharmacokinetics, a large amount of alcoholic beverage is drunk at one time, the absorption of ethanol follows the first-order kinetic rule,solving this equation can give +.>This expression may reflect the in vivo absorption of ethanol, where k Absorption of Is the absorption constant of the individual.
The elimination of ethanol in vivo is a zero-order kinetic process, namely the elimination rate is a constant, and is irrelevant to the ethanol quantity in vivo, and the mathematical expression is as follows:solving the equation to x Elimination of (t)＝-k Elimination of t is; wherein k is Elimination of Ethanol elimination constants for individuals.
Therefore, the change amount of ethanol in the body at time t is the superposition of the absorption amount and the clearance amount, and the expression is as follows:solving the equation to +.>Representing the ethanol content in human body at time t.
Thereby knowing k Absorption of 、k Elimination of The slope of the two parts of straight lines of the first-order drug generation curve is obtained by a linear fitting mode.
In one embodiment of the invention, the sobering-up time is determined in the following manner:
(1) Sample selection
The selected sample population consists of 10 adult individuals, 7 men and 3 women, wherein the required age distribution is reasonable, the wine quantity is distributed uniformly in the range of 25-35 years, and the wine is forbidden three days before the test.
(2) Wine selection and dosage
The alcohol liquor to be tested is selected from Jiujiang twelve mill alcohol degree 40%, meanwhile, 40% pure alcohol solution is prepared as a comparison group, conversion is carried out according to 0.8g alcohol/kg body weight, the testers are divided into two groups, and the alcohol liquor to be tested and the pure alcohol solution are respectively prepared; the specific wine amounts are shown in table 1 below:
table 1 twelve sample drink shop dose statistics table
(3) Principle of drinking
The same food is matched, the personnel to be tested is required to finish drinking the wine at a constant speed within 30min, and the timing is started at the first drinking time point.
(4) And detecting the blood alcohol concentration of the testers every 5min by using an alcohol tester until the blood alcohol concentration of the testers is reduced to below 15mg/100ml, and completing the test.
(5) The test person sobering-up time and the results are shown in table 2.
TABLE 2 twelve different testers and alcohol sobering-up time statistics table
In one embodiment of the present invention, the statistical analysis of the sobering-up time of the tester is specifically as follows:
(1) As shown in FIG. 1, the average sobering-up time of the twelve mill products was 111.9min, and the sobering-up time of the alcohol was 122.1min, exceeding the sobering-up time of the twelve mill products by 9.11%, according to the drinking doses in Table 1. Meanwhile, the sobering-up time of ten test samples for drinking twelve workshops is 100% less than that of alcohol, and the obvious difference is found in the experiment.
Based on the detection samples, the average value test is carried out on the sobering-up time of two products, the sobering-up time of the original assumption is shorter than that of twelve mill, the sobering-up time of the alternative assumption is shorter than that of the alcohol sample, and the significance test is carried out under the confidence level of 0.95, as follows:
H 0 ：μ 2 -μ 1 ≥0，
H 1 ：μ 2 -μ 1 ＜0。
since t < critical value, rejecting the original hypothesis, accepting alternative hypothesis, namely sobering time of twelve frames 2 Less than the sobering-up time mu of alcohol 1 。
(2) And drawing a relation curve of the ethanol metabolism blood concentration and time of a tester of the twelve-shop product of the wine to be tested, as shown in figure 2. The sobering time of the test sample to the Jiujiang dodecary is known from the fitting curve, and when the test sample starts drinking until the blood concentration is y=15 g/100ml, the sobering time X= (48.213-15)/0.3659 = 90.919min is calculated according to y= -0.3659x+48.213.
The ethanol metabolism blood concentration of the test person of the pure alcohol solution was plotted against time as shown in fig. 3.
The sobering time of the test sample for alcohol is calculated from y= -0.2662x+48.287 from when the test sample starts drinking until the blood concentration is y=15 g/100ml, and the sobering time x= (48.287-15)/0.2662 =125.04 min.
The embodiments described above are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the embodiments described above, and any other changes, modifications, substitutions, combinations, and simplifications that do not depart from the spirit and principles of the present invention should be made in the equivalent manner, and are included in the scope of the present invention.
Claims (6)
1. A method for detecting the sobering-up time of distilled spirit, comprising the steps of:
s1, establishing a sobering-up time analysis model
The distilled liquor sobering-up time is defined as: after distilled liquor enters a human body, the total time of absorption and removal of the alcohol by the human body is calculated, and the removal time is calculated according to the duration of time when the blood concentration of the human body is reduced to below 15mg/100ml, and the unit is calculated according to minutes;
according to the principle of pharmacokinetics, a large amount of alcoholic beverage is drunk at one time, the absorption of ethanol follows the first-order kinetic rule, and the absorption power equation of ethanol is as follows:
wherein k is Absorption of An absorption constant for an individual;
solving the equation to obtainExpression reflecting the in vivo absorption status of ethanol:
the elimination of ethanol in vivo is a zero order kinetic process, namely the elimination rate is a constant, and the chemical expression of the elimination of ethanol in vivo is as follows:
thus, the ethanol change in the body at time t is the superposition of the absorption and the removal, and the expression is that
Solving the equation as
The X (t) represents the content of ethanol in a human body at the moment t;
s2, measuring sobering-up time:
s21, selecting sample population, and performing wine forbidden three days before testing;
s22, referring to the concentration of the wine to be tested, preparing a pure alcohol solution with the same concentration as a control group, dividing a tester into a sample group and the control group, and respectively preparing the wine to be tested and the pure alcohol solution;
s23, the same food is matched, a tester is required to finish drinking wine at a constant speed within 30min, and timing is started at a first drinking time point;
s24, detecting the blood alcohol concentration of a tester by using an alcohol tester every 5min until the blood alcohol concentration of a tester is reduced to below 15mg/100ml, and completing the test;
s3, statistical analysis of sobering-up time of testers:
s31, judging whether the sample data of the wine to be tested and the sample data of the pure alcohol solution have significant differences, and performing significant verification;
s32, respectively drawing a relationship curve of the ethanol metabolism blood concentration and time of a tester of the wine to be tested and a relationship curve of the ethanol metabolism blood concentration and time of a tester of the pure alcohol solution, and performing model fitting; respectively obtaining k in the equation (1) corresponding to the wine to be measured Elimination of And eliminating the Y-axis intercept b of the fitting straight line; and k in equation (1) corresponding to pure alcohol solution Elimination of And eliminating the Y-axis intercept b of the fitting straight line;
according to sobering-up time= (b-15)/k Elimination of The unit is minutes;
and respectively calculating the sobering-up time of the to-be-detected wine and the pure alcohol solution.
2. The method for detecting the time to sober up of distilled spirit according to claim 1, wherein the sample population in step S21 is composed of 10 adult persons, 7 men and 3 women.
3. The method for detecting the time to sober up of distilled spirit according to claim 1 or 2, wherein the age of the sample population in step S21 is 25 to 35 years old.
4. The method for detecting a time to sober up of distilled spirit according to claim 1, wherein the sample population in step S21 has a uniform distribution of the amount of spirit.
5. The method for detecting a time to sober up of distilled spirit according to claim 1, wherein the performing of the significance verification in step S31 is specifically:
and (3) carrying out average value test on the sobering-up time of the to-be-tested wine and the pure alcohol solution, wherein the original assumption is that the sobering-up time of the pure alcohol sample is shorter than that of the to-be-tested wine, and the alternative assumption is that the sobering-up time of the to-be-tested wine is shorter than that of the pure alcohol solution, and carrying out significance verification under the confidence level of 0.95.
6. The method for detecting a sobering-up time of distilled spirit according to claim 1, wherein in step S22, the to-be-detected liquid and the pure alcohol solution are respectively added, specifically:
according to the weight of 0.8g ethanol/kg, respectively adding the wine to be tested and the pure alcohol solution.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101850127A (en) * | 2010-05-26 | 2010-10-06 | 四川省绵阳市丰谷酒业有限责任公司 | White spirit drunkenness degree evaluation model |
| CN202965967U (en) * | 2012-11-06 | 2013-06-05 | 长安大学 | Drunk driving prevention safety device |
| CN106290473A (en) * | 2015-05-29 | 2017-01-04 | 富泰华工业（深圳）有限公司 | Drunk detecting system and method |
| CN111007214A (en) * | 2019-12-27 | 2020-04-14 | 广东省九江酒厂有限公司 | Method for measuring alcoholic intoxication degree by human body model |
| CN116416192A (en) * | 2021-12-30 | 2023-07-11 | 华为技术有限公司 | Detection method and device |
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2023
- 2023-12-27 CN CN202311825303.2A patent/CN117871840A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101850127A (en) * | 2010-05-26 | 2010-10-06 | 四川省绵阳市丰谷酒业有限责任公司 | White spirit drunkenness degree evaluation model |
| CN202965967U (en) * | 2012-11-06 | 2013-06-05 | 长安大学 | Drunk driving prevention safety device |
| CN106290473A (en) * | 2015-05-29 | 2017-01-04 | 富泰华工业（深圳）有限公司 | Drunk detecting system and method |
| CN111007214A (en) * | 2019-12-27 | 2020-04-14 | 广东省九江酒厂有限公司 | Method for measuring alcoholic intoxication degree by human body model |
| CN116416192A (en) * | 2021-12-30 | 2023-07-11 | 华为技术有限公司 | Detection method and device |
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