CN117815582A - FLASH treatment system, beam safety locking method and related equipment - Google Patents
FLASH treatment system, beam safety locking method and related equipment Download PDFInfo
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Abstract
The application provides a FLASH treatment system, a beam safety locking method and related equipment, and relates to the technical field of particle radiotherapy, wherein the method comprises the following steps: acquiring the proton charge quantity output by single beam output as a first charge quantity; judging whether the first charge quantity exceeds a first threshold value; and performing beam-out control according to the judgment result: if the first charge amount exceeds a first threshold; then a first security lock is performed to prohibit the beam from being output; if not, allowing one-time beam outlet, determining the beam locking time length, and performing second safety locking in the beam outlet locking time length; wherein during the second security lock no loading of the outgoing beam is allowed. The proton FLASH treatment device is used for carrying out beam-out control according to the requirements of users, and is safe and interlocked, so that the accelerator can not draw out proton beam current in a period of time after the beam FLASH is drawn out, the average dosage rate taking hours as a time scale is reduced, the proton FLASH treatment can be realized by a common proton accelerator machine room, and the popularization of the proton FLASH treatment is facilitated.
Description
Technical Field
The application relates to the technical field of particle radiotherapy, in particular to a FLASH treatment system, a beam safety locking method and related equipment.
Background
In the field of particle radiotherapy, the accuracy of dose calculation is one of the determining factors for achieving a good therapeutic effect. For proton radiotherapy, proton dose calculation methods involve two main approaches, analytical and Monte Carlo simulation. Analysis often converts Hounsfield Units (HU) values from CT scans to a stopping power ratio for dose calculation. While this may not involve voxel specific tissue composition, such analysis algorithms may be difficult to provide accurate dose calculations when dealing with heterogeneous media (such as the lungs). Because these algorithms can only perform approximate calculations in terms of multiple elastic coulomb scattering, elastic and inelastic nuclear reactions, etc., accurate modeling cannot be achieved.
Flash therapy is a novel non-invasive external radiation radiotherapy technique, in which a single radiation dose is given in a non-invasive manner for a very short period of time, resulting in a very high radiation dose rate (typically, radiation with an average dose rate exceeding 100Gy/s is given in 50 ms), which is applied to biological cells or tissues in a method called Flash therapy (Flash radiation therapy). Flash therapy delivers high irradiation doses in very short times (< 0.1 s) compared to conventional dose rate (1-7 cGy/s) radiotherapy. High dose rate irradiation results in oxygen depletion in the tissue, which renders healthy tissue radiation resistant, enabling dose escalation treatment to destroy tumor tissue under high hypoxic conditions. Test results show that Flash treatment greatly reduces damage to normal tissue with consistent and even better tumor control rates. Compared with conventional radiotherapy, the incidence rate of the radiodermatitis treated by the proton Flash is reduced by 35 percent on average. According to the requirements on radiation safety and protection, in a common proton accelerator machine room, namely a machine room designed by taking non-FLASH beam intensity as a radiation source item, FLASH beam is not allowed to be led out, or a very thick shielding wall body is required to be designed, so that the dosage rate of the accelerator outside the machine room is lower than 2.5 mu Sv/h when the proton beam is led out. Because the required wall body is particularly thick, the household FLASH proton machine room is not located in a hospital. From the perspective of thickening the wall, the dosage rate outside the machine room is reduced. How to implement FLASH operation in the ordinary proton accelerator computer lab to avoid carrying out special bodiness to the proton accelerator computer lab wall body, be the technical problem that this application was solved.
Disclosure of Invention
The invention aims to provide a safe locking method and related equipment for FLASH beam current, which are used for beam output control according to user requirements, and design a safe linkage, so that an accelerator cannot draw out proton beam current any more in a period of time after outputting the FLASH beam current, and the average dose rate taking an hour as a time scale is reduced.
The purpose of the application is realized by adopting the following technical scheme:
in a first aspect, the present application provides a method for safely locking a FLASH beam, where the method includes:
acquiring the proton charge quantity output by single beam output as a first charge quantity;
judging whether the first charge quantity exceeds a first threshold value;
and performing beam-out control according to the judgment result: if the first charge amount exceeds a first threshold; then a first security lock is performed to prohibit the beam from being output; if not, the beam is allowed to be output, and the beam locking time length is calculated.
Further, the FLASH beam current safety locking method includes that if not, beam output is allowed, and the calculated beam output locking time length includes that the first electric quantity is smaller than or equal to a first threshold value, one-time beam output is allowed, the beam locking time length is determined, and second safety locking is carried out within the beam output locking time length; wherein during the second security lock no loading of the outgoing beam is allowed.
Optionally, the duration of the beam-out locking is as follows:
T＝N/A y ×3600-t
wherein T is the beam-out locking time; t is the irradiation time, 3600 units are seconds, and N is the first charge amount; a is that y Is a first threshold. Optionally, the duration of the beam-out locking is as follows:
when the first charge amount is smaller than the second threshold value, t=t1;
when the first charge amount is equal to or greater than the second threshold value and is less than the third threshold value, t=t2;
when the first charge amount is equal to or greater than the third threshold value, t=t3;
wherein T is the beam-out locking time, and T1, T2 and T3 are respectively preset time.
Optionally, the method for safely locking the FLASH beam includes:
T＝N/A y ×3600
wherein T is the beam-out locking time; 3600 units are seconds, and N is a first charge amount; a is that y Is a first threshold.
Preferably, the method for locking FLASH beam security, the first threshold includes:
A y ＝K×(I y ×3600)
wherein A is y Is a first threshold value, I y For presetting beam outlet proton flow intensity, the unit is nA, K coefficient, K>0。
In another aspect, the present application provides a FLASH beam safety locking device, the device including:
an output charge amount acquisition module: the proton charge quantity used for obtaining the single beam output is taken as a first charge quantity;
a determining module configured to determine whether the first charge amount exceeds a first threshold;
the execution module is used for carrying out beam-out control according to the judgment result: if the first charge amount exceeds a first threshold; then a first security lock is performed to prohibit the beam from being output; if not, the beam is allowed to be output, and the beam locking time length is calculated.
In a third aspect, the present application provides an electronic device comprising a memory storing a computer program and at least one processor configured to implement the following steps when executing the computer program:
acquiring the proton charge quantity output by single beam output as a first charge quantity;
judging whether the first charge quantity exceeds a first threshold value;
and performing beam-out control according to the judgment result: if the first charge amount exceeds a first threshold; then a first security lock is performed to prohibit the beam from being output; if not, the beam is allowed to be output, and the beam locking time length is calculated.
Optionally, the electronic device described herein, the at least one processor is configured to obtain the beam lock time length when executing the computer program by:
T＝N/A y ×3600-t
wherein T is the beam-out locking time; t is the irradiation time, 3600 units are seconds, and N is the first charge amount; a is that y Is a first threshold.
Optionally, the electronic device described herein, the at least one processor is configured to obtain the beam lock time length when executing the computer program by:
when the first charge amount is smaller than the second threshold value, t=t1;
when the first charge amount is equal to or greater than the second threshold value and is less than the third threshold value, t=t2;
when the first charge amount is equal to or greater than the third threshold value and is less than the fourth threshold value, t=t3;
wherein T is the beam-out locking time, and T1, T2 and T3 are respectively preset time.
Optionally, the electronic device described herein, the at least one processor is configured to obtain the beam lock time length when executing the computer program by:
T＝N/A y ×3600
wherein T is the beam-out locking time; 3600 units are seconds, and N is a first charge amount; a is that y Is a first threshold.
In a fourth aspect, the present application provides a FLASH therapy system, the therapy system comprising:
radiotherapy equipment and any FLASH beam safety locking device described in the application;
the radiotherapy apparatus is for performing radiotherapy on a patient.
In a fifth aspect, the present application provides a computer readable storage medium storing computer instructions that, when read by a computer, perform a method of any one of the FLASH beam security locking described herein.
The effects of the application include at least: by judging whether the first charge quantity exceeds a first threshold value, the safe control of the output of the proton beam is realized. If the first amount of charge exceeds a threshold, the system will perform a first security lock, prohibiting beam out, to avoid a possible security risk. Thus, the safety of the proton treatment equipment can be improved, and the safety of patients and operators can be protected. And allowing one beam to be emitted when the first charge amount is smaller than or equal to a first threshold value, and performing second safety locking according to the set beam emitting locking time. The flexible beam-out control mode can be adjusted according to specific requirements, ensures that the output of the proton beam is in a safe range, and provides effective treatment for patients. And the second safety locking is carried out within the beam-out locking time, so that the beam-out current is not allowed to be loaded, and unsafe radiation leakage is effectively prevented. Thus, the surrounding environment and staff can be protected from unnecessary radiation exposure, and the requirements of radiation safety management are met. By the method, the safety of the FLASH beam current can be improved, the beam output can be flexibly controlled, and radiation leakage can be effectively prevented and controlled. This will help to improve the safety performance of the proton treatment apparatus, ensure the safety of the patient and the operator, and provide a reliable treatment effect for proton treatment. The external dose rate of the proton accelerator machine room (including the common proton accelerator machine room) is ensured to be lower than the requirements of radiation safety and protection, the common proton accelerator machine room can also realize proton FLASH treatment, is beneficial to popularization of the proton FLASH treatment, and provides a guarantee for more patients to obtain proton FLASH treatment opportunities.
Drawings
The present application is further described below with reference to the drawings and examples.
Fig. 1 is a schematic diagram of a method for safely locking a FLASH beam according to an embodiment of the present application;
fig. 2 is a flow chart of a method for safely locking a FLASH beam according to an embodiment of the present application;
FIG. 3 is a schematic diagram of a common proton accelerator machine room load shield design;
fig. 4 is a schematic structural diagram of an electronic device according to an embodiment of the present application.
Detailed Description
The present application will be further described with reference to the drawings and detailed description, which should be understood that, on the premise of no conflict, the following embodiments or technical features may be arbitrarily combined to form new embodiments.
Before introducing the present application, the safety control requirements for radiation and treatment relief are first introduced:
limiting the out-wall dose rate reference control level to 2.5 mu Sv/h, but in the prior shielding design process, taking seconds as time intervals, calculating the maximum dose rate per second, and converting the maximum dose rate into hours; whereas conventional beam current is continuously beam-emitting, allowing for continuous beam-emitting over a period of 1 hour (or approximately 1 hour);
the ambient dose equivalent rate at 30cm (point of interest) outside the walls and entrance door of the treatment room (excluding the mobile electric accelerator treatment room) should be no greater than the ambient dose equivalent rate reference control level determined by a), b) and c) below
a) Using the radiation treatment weekly workload, the usage factor of the point of interest location, and the dwelling factor, a circumferential dose equivalent rate reference control level of the point of interest is obtained from the weekly dose reference control levelSee formula (1)
Reference control level for ambient dose equivalent rate in units of micro-Highatt per hourTime (. Mu.Sv/h);
H e for the weekly dose reference control level, the unit is micro-Highatt weekly (mu Sv/week), and the value is taken by staff in a control area outside a radiotherapy machine room, namely less than or equal to 100 mu Sv/week; personnel in a non-control area outside the radiotherapy machine room are less than or equal to mu Sv/week;
t z the number of hours per week (h/week) is the maximum cumulative exposure per week of the apparatus;
u is a use factor of irradiation of the treatment equipment to the direction of the position of the attention point;
y is the residence factor of the person at the point of interest position;
b) Determining the highest surrounding dose equivalent rate reference control level of the point of interest according to the difference of the residence factors of the personnel of the point of interest
1) Factor T of personnel residence>1/2 locale:
2) The place where the personnel residence factor T is less than or equal to 1/2:
c) Reference control level sheet from derived ambient dose equivalent rate in a) aboveAnd b) highest ambient dose equivalent rate reference control level +.>Selecting the surrounding dose equivalent rate reference control level with the smaller one as the point of interest +.>
Through radiation critique and shielding design, simulation calculation is carried out by using the proton flow intensity of the beam outlet of 1.2nA, and the out-wall dose rate reference control level is within 2.5 mu Sv/h within one hour.
Referring to fig. 1, an embodiment of the present application provides a method for locking FLASH beam security, where the method includes:
acquiring the proton charge quantity output by single beam output as a first charge quantity;
judging whether the first charge quantity exceeds a first threshold value;
and performing beam-out control according to the judgment result: if the first charge amount exceeds a first threshold; then a first security lock is performed to prohibit the beam from being output; if not, the FLASH safety lock is green, the beam is allowed to be emitted, and the beam emitting locking time after the beam is emitted is calculated.
In one embodiment of the present application, if not, the beam is allowed to be emitted, and the beam emitting locking duration is calculated, where the first charge amount is less than or equal to a first threshold, and the beam is allowed to be emitted once, and the beam locking duration is determined, and a second security locking is performed within the beam emitting locking duration; wherein during the second security lock no loading of the outgoing beam is allowed.
And performing second safety locking in the beam-out locking time. During this period, no beam is loaded to prevent unsafe radiation leakage. After the second safety lock is finished, the beam can be reloaded for treatment.
The working principle of the technical scheme is as follows: the proton charge amount of the single beam output is acquired as the first charge amount. This process is achieved by beam-out planning, which is formulated according to the treatment requirements and the equipment parameters. In particular, the beam-out plan refers to a plan that determines the output intensity and distribution of the proton beam over time to achieve a therapeutic goal.
It is determined whether the first amount of charge exceeds a first threshold. The first threshold is a preset upper limit of proton charge amount, and if the first charge amount exceeds the threshold, the first threshold indicates that a safety risk is likely to exist, and safety locking is required.
And performing beam-output control according to the judgment result. If the first amount of charge exceeds a first threshold, a first safety lock is performed to inhibit beam out to prevent unsafe radiation leakage. If the first amount of charge does not exceed the first threshold, beam exit is allowed and a beam lock time period is calculated.
And controlling the output of the beam current by calculating the beam locking time length. When the secondary proton beam output is finished, the system locks, i.e. the beam-out locking duration. During this period, the proton beam is still disabled from being output until the beam-out lock period reaches a preset length of time, and then is allowed to be re-output. The method can realize safety control by detecting the charge quantity of the proton beam in real time, ensure the output of the proton beam in a safety range and prevent the radiation leakage from damaging human bodies and the environment.
The technical scheme has the effects that: by judging whether the first charge quantity exceeds a first threshold value, the safe control of the output of the proton beam is realized. If the first amount of charge exceeds a threshold, the system will perform a first security lock, prohibiting beam out, to avoid a possible security risk. Thus, the safety of the proton treatment equipment can be improved, and the safety of patients and operators can be protected. And allowing one beam to be emitted when the first charge amount is smaller than or equal to a first threshold value, and performing second safety locking according to the set beam emitting locking time. The flexible beam-out control mode can be adjusted according to specific requirements, ensures that the output of the proton beam is in a safe range, and provides effective treatment for patients. And the second safety locking is carried out within the beam-out locking time, the beam-out current is not loaded, and unsafe radiation leakage is effectively prevented. Thus, the surrounding environment and staff can be protected from unnecessary radiation exposure, and the requirements of radiation safety management are met. By the method, the safety of the FLASH beam current can be improved, the beam output can be flexibly controlled, and radiation leakage can be effectively prevented and controlled. This will help to improve the safety performance of the proton treatment apparatus, ensure the safety of the patient and the operator, and provide a reliable treatment effect for proton treatment.
According to the FLASH beam safety locking method, the beam locking duration is as follows:
T＝N/A y ×3600-t
wherein T is the beam-out locking time; t is the irradiation time, 3600 units are seconds, N is the thA charge amount; a is that y Is a first threshold.
In another embodiment of the present application, the duration of the beam-out locking is:
T＝N/A y ×3600
wherein T is the beam-out locking time; 3600 units are seconds, and N is a first charge amount; a is that y Is a first threshold.
The working principle of the technical scheme is as follows: according to the first charge amount N and the first threshold A y And calculating the beam-out locking time length T of the beam current. Specifically, N/A in the formula y Representing the ratio between the current proton beam charge amount and the set first threshold. The larger this ratio, the larger the output charge of the proton beam, and the longer the lock-in time should be required to ensure therapeutic safety. N/A y The purpose of multiplying 3600 is to convert the result into seconds for comparison with the illumination time t. And during the beam-out locking time, performing second safety locking, and prohibiting continuous output of the proton beam so as to avoid radiation leakage and patient injury.
The technical scheme has the effects that: according to the beam-out locking time length algorithm, a first threshold value A is adjusted y The beam-out locking time of the proton beam can be flexibly controlled. When the charge quantity of the proton beam is small and does not exceed a first threshold value, the proton beam can be quickly unlocked and treatment can be performed; and when the electric charge quantity exceeds the threshold value, the locking mechanism is automatically triggered to carry out safety locking. This adjustability allows for greater flexibility and safety in proton beam therapy. Because the charge quantity and the irradiation time of the proton beam are obtained in real time, the proper beam-out locking time length can be accurately calculated according to different treatment requirements and actual conditions, and the treatment effect is improved to the greatest extent on the premise of ensuring safety. The safe locking method of the FLASH beam current can prevent the risk of equipment failure or damage caused by overlarge proton beam output. Through limiting the output electric charge quantity and setting the beam-out locking time length, the service life of the equipment can be effectively prolonged, and the maintenance and replacement cost is reduced. In general, the method improves FLASH beam treatment by setting threshold value, dynamically adjusting the beam-out locking time length and the likeThe safety and reliability of the treatment are ensured, and the maximization of the treatment effect is ensured.
In another embodiment of the present application, the duration of the beam-out locking is:
when the first charge amount is smaller than the second threshold value, t=t1;
when the first charge amount is equal to or greater than the second threshold value and is less than the third threshold value, t=t2;
when the first charge amount is equal to or greater than the third threshold value and is less than the fourth threshold value, t=t3; and so on;
wherein T is the beam-out locking time, and T1, T2 and T3 are respectively preset time; t1 is between 400 and 700 seconds, preferably 600 seconds; t3> T2> T1;
wherein the third threshold may be 2 times the second threshold and the fourth threshold may be three times the second threshold, with a corresponding T2 being twice T1 and a corresponding T3 being three times T1. The second threshold value, the third threshold value and the fourth threshold value are respectively smaller than or equal to the first threshold value; the second threshold is between 600C and 800C, preferably 720C (coulomb).
The working principle of the technical scheme is as follows: according to different ranges of the first electric charge quantity, the system can automatically select corresponding beam-out locking time periods to limit. When the first electric charge quantity is in a specific range, triggering a corresponding preset time length to limit the output time of the proton beam, and ensuring the safety of treatment. The system needs to monitor the first charge amount at the output of the proton beam in real time in order to judge the current situation and respond. Through accurate monitoring and data acquisition, timely control and adjustment of proton beam output can be ensured, and potential safety risks caused by overlarge output are avoided. The output time length of the proton beam in different ranges can be flexibly adjusted according to actual requirements by setting the multiple relation between the second threshold, the third threshold and the fourth threshold and the preset time length. Thus, the beam current can be controlled in a grading manner according to the first electric charge quantity, and the balance of the treatment effect and the safety is ensured. Aiming at the condition of different first electric charge amounts, the system needs to have a quick response speed, and can realize adjustment of the beam-out locking duration in millisecond level. Therefore, when abnormal conditions occur during proton beam output, the system can rapidly respond, and the safety of treatment is ensured. In summary, by dynamically adjusting the beam-out locking time length, monitoring the first charge amount, the threshold multiple relationship, the system response speed and the like, the technical scheme of setting the beam-out locking time length according to the situations can realize the fine control of the FLASH beam output, thereby ensuring the safety and the adjustability of treatment.
The technical scheme has the effects that: the grading control of the FLASH beam current output can be realized by adjusting the beam-out locking time based on the first electric charge quantity. Therefore, different beam-out locking duration limits can be realized in different charge quantity ranges according to specific proton beam output conditions, so that different treatment requirements are better adapted, and safe radiation is ensured; different preset durations T1, T2 and T3 are set, and the time point of proton beam output can be effectively controlled by combining the threshold multiple relationship, so that excessive beam current effect can not occur in the treatment process, and the treatment safety is improved. And setting proper preset time length and threshold according to specific requirements, so that the system has stronger adjustability. Thus, the treatment device can be flexibly adjusted according to the conditions of different patients and the needs of different treatment stages, and the individuation and pertinence of treatment are improved. By setting a proper threshold value and a preset time length, the impact and pressure on the system can be reduced, so that the stability and reliability of the system are improved, and the normal operation of the system in long-time operation is ensured. The second threshold value and the preset time period can optimize the performance of the system to a certain extent, so that the system can realize better output effect under different working conditions, and the overall performance of the system is improved. In summary, the FLASH beam safety locking method can realize the fine control and safety guarantee of beam output, improves the adjustability and stability of the system, and provides a safer, more effective and personalized solution for medical treatment.
An embodiment of the present application provides a method for locking FLASH beam security, where the first threshold includes:
A y ＝K×(I y ×3600)
wherein A is y Is a first threshold value, I y For presetting beam outlet proton flow intensity, the unit is nA, K coefficient, K>0；I y Preferably 1.2nA.
The working principle of the technical scheme is as follows: the first threshold calculation is performed by:
A y ＝K×(I y ×3600)
wherein A is y Represents a first threshold, expressed in coulombs (C), I y Represents the proton flow intensity of a preset beam outlet, the unit is nanoampere (nA), and K is a coefficient (K>0). By preset proton flow intensity I y To calculate a first threshold I y 。
K＝t s ×I y /I a
Wherein t is s Setting a cutting time scale for a user, wherein the unit is hour, I a The unit is nanoampere (nA) for the actual beam outlet proton flow intensity;
according to the simulation result, I y At 1.2nA, the out-wall dose rate reference control level is within 2.5 μSv/h; and the simulation was calculated by one hour time slicing,
in practical application, the beam port proton flow capacity of the device can reach 35-50 nA; at the same time, different users may cut different time scales, which may be one half hour, 20 minutes, etc., so that a coefficient K is set, different thresholds can be adjusted according to the cutting time scale of the users and the actual proton current intensity, and the thresholds are determined according to the actual system performance and the treatment requirement, so as to ensure the accuracy and operability of the safety locking.
If the beam current charge is less than or equal to the first threshold A y Normal beam-out; and after the beam is emitted, the system enters a locking state, and a corresponding beam emitting locking time length T is set according to a preset time length.
The upper threshold limit can be preset according to the real-time proton flow intensity and time cutting requirements, and the safe limit on the FLASH beam output is realized. When the proton flow intensity exceeds a preset value, the system can automatically trigger a locking mechanism to ensure that the beam output is in a safe range and lock according to a preset time length. Thus, the safety of patients and equipment can be effectively protected, and the controllability and the accuracy of treatment are improved.
The application also provides a FLASH beam safety locking device, which comprises:
an output charge amount acquisition module: the proton charge quantity used for obtaining the single beam output is taken as a first charge quantity;
a determining module configured to determine whether the first charge amount exceeds a first threshold;
the execution module is used for carrying out beam-out control according to the judgment result: if the first charge amount exceeds a first threshold; then a first security lock is performed to prohibit the beam from being output; if not, the beam is allowed to be output, and the beam locking time length is calculated.
The execution module specifically comprises: the first charge amount is smaller than or equal to a first threshold value, one-time beam output is allowed, after the one-time beam output, the beam locking duration is determined, and second safety locking is carried out within the beam output locking duration; wherein during the second security lock, no outgoing beam is loaded.
In some embodiments, the outgoing lock time period in the execution module is:
T＝N/A y ×3600-t
wherein T is the beam-out locking time; t is the irradiation time, 3600 units are seconds, and N is the first charge amount; a is that y Is a first threshold.
In other embodiments, the outgoing lock duration in the execution module is:
T＝N/A y ×3600
wherein T is the beam-out locking time; 3600 units are seconds, and N is a first charge amount; a is that y Is a first threshold.
In other embodiments, the outgoing lock duration in the execution module is:
when the first charge amount is smaller than the second threshold value, t=t1;
when the first charge amount is equal to or greater than the second threshold value and is less than the third threshold value, t=t2;
when the first charge amount is equal to or greater than the third threshold value and is less than the fourth threshold value, t=t3; and so on;
wherein T is the beam-out locking time, and T1, T2 and T3 are respectively preset time; t1 is between 400 and 700 seconds, preferably 600 seconds; t3> T2> T1;
wherein the third threshold may be 2 times the second threshold and the fourth threshold may be three times the second threshold, with a corresponding T2 being twice T1 and a corresponding T3 being three times T1. The second threshold value, the third threshold value and the fourth threshold value are respectively smaller than or equal to the first threshold value; the second threshold is between 600C and 800C, preferably 720C (coulomb).
The first threshold may be set according to a requirement of a user, specifically:
A y ＝K×(I y ×3600)
wherein A is y Represents a first threshold, expressed in coulombs (C), I y Represents the proton flow intensity of a preset beam outlet, the unit is nanoampere (nA), and K is a coefficient (K>0). By preset proton flow intensity I y To calculate a first threshold I y 。
K＝t s ×I y /I a
Wherein t is s Setting a cutting time scale for a user, wherein the unit is hour, I a The unit is nanoampere (nA) for the actual beam outlet proton flow intensity;
according to the simulation result, I y At 1.2nA, the out-wall dose rate reference control level is within 2.5 μSv/h; and the simulation was calculated by one hour time slicing,
in practical application, the beam port proton flow capacity of the device can reach 35-50 nA; at the same time, different users may cut different time scales, which may be one half hour, 20 minutes, etc., so that a coefficient K is set, different thresholds can be adjusted according to the cutting time scale of the users and the actual proton current intensity, and the thresholds are determined according to the actual system performance and the treatment requirement, so as to ensure the accuracy and operability of the safety locking.
The working principle and effect of the steps are the same as those of the embodiment FLASH beam safety locking method, and are not described in detail herein.
Some embodiments of the present application provide an electronic device comprising a memory storing a computer program and at least one processor configured to, when executing the computer program, implement the steps of:
acquiring the proton charge quantity output by single beam output as a first charge quantity;
judging whether the first charge quantity exceeds a first threshold value;
and performing beam-out control according to the judgment result: if the first charge amount exceeds a first threshold; then a first security lock is performed to prohibit the beam from being output; if not, allowing beam to be output, and calculating the beam locking time; the method comprises the following steps: allowing one-time beam discharge if the first charge quantity is smaller than or equal to a first threshold value, determining a beam locking duration, and performing second safety locking in the beam discharging locking duration; wherein during the second security lock no loading of the outgoing beam is allowed.
In some embodiments, the at least one processor is configured to obtain the fetch beam lock duration when executing the computer program by:
T＝N/A y ×3600-t
wherein T is the beam-out locking time; t is the irradiation time, 3600 units are seconds, and N is the first charge amount; a is that y Is a first threshold.
In some other embodiments, the at least one processor is configured to obtain the fetch beam lock duration when executing the computer program by:
T＝N/A y ×3600
wherein T is the beam-out locking time; t is the irradiation time, 3600 units are seconds, and N is the first charge amount; a is that y Is a first threshold.
In some other embodiments, the at least one processor is configured to obtain the fetch beam lock duration when executing the computer program by:
when the first charge amount is smaller than the second threshold value, t=t1;
when the first charge amount is equal to or greater than the second threshold value and is less than the third threshold value, t=t2;
when the first charge amount is equal to or greater than the third threshold value and is less than the fourth threshold value, t=t3;
wherein T is the beam-out locking time, and T1, T2 and T3 are respectively preset time.
In some other embodiments, the at least one processor is configured to obtain the fetch beam lock duration when executing the computer program by:
T＝N/A y ×3600
wherein T is the beam-out locking time; 3600 units are seconds, and N is a first charge amount; a is that y Is a first threshold.
The first threshold may be set according to a requirement of a user, specifically:
A y ＝K×(I y ×3600)
wherein A is y Represents a first threshold, expressed in coulombs (C), I y Represents the proton flow intensity of a preset beam outlet, the unit is nanoampere (nA), and K is a coefficient (K>0). By preset proton flow intensity I y To calculate a first threshold I y 。
K＝t s ×I y /I a
Wherein t is s Setting a cutting time scale for a user, wherein the unit is hour, I a The actual beam outlet proton flow intensity; the unit is nanoamperes (nA);
according to the simulation result, I y At 1.2nA, the out-wall dose rate reference control level is within 2.5 μSv/h; and the simulation was calculated by one hour time slicing,
in practical application, the beam port proton flow capacity of the device can reach 35-50 nA; at the same time, different users may cut different time scales, which may be one half hour, 20 minutes, etc., so that a coefficient K is set, different thresholds can be adjusted according to the cutting time scale of the users and the actual proton current intensity, and the thresholds are determined according to the actual system performance and the treatment requirement, so as to ensure the accuracy and operability of the safety locking.
The working principle and effect of the steps are the same as those of the embodiment FLASH beam safety locking method, and are not described in detail herein.
Embodiments of the present application provide a FLASH therapy system, the therapy system comprising:
radiation treatment equipment and any FLASH beam safety locking device disclosed by the embodiment of the application;
the radiotherapy apparatus is for performing radiotherapy on a patient.
Embodiments of the present application provide a computer readable storage medium storing computer instructions, where when a computer reads the computer instructions, the computer executes the FLASH beam security locking method according to any one of the embodiments.
The memory 210 in this embodiment may include readable media in the form of volatile memory, such as Random Access Memory (RAM) 211 and/or cache memory 212, and may further include Read Only Memory (ROM) 213.
The memory 210 further stores a computer program, and the computer program may be executed by the processor 220, so that the processor 220 executes the steps of the method for calculating the proton dose for tissue segmentation based on the sketched area in the embodiment of the present application, and a specific implementation manner of the method is consistent with the implementation manner and the achieved technical effect described in the embodiment of the method for calculating the proton dose for tissue segmentation based on the sketched area, and some contents are not repeated.
Memory 210 may also include utility 214 having at least one program module 215, such program modules 215 including, but not limited to: an operating system, one or more application programs, other program modules, and program data, each or some combination of which may include an implementation of a network environment.
Accordingly, the processor 220 may execute the computer programs described above, and may execute the utility 214.
Bus 230 may be a local bus representing one or more of several types of bus structures including a memory bus or memory controller, a peripheral bus, an accelerated graphics port, a processor, or using any of a variety of bus architectures.
The electronic device 200 may also communicate with one or more external devices 240, such as a keyboard, pointing device, bluetooth device, etc., as well as one or more devices capable of interacting with the electronic device 200 and/or with any device (e.g., router, modem, etc.) that enables the electronic device 200 to communicate with one or more other computing devices. Such communication may occur through input-output interface 250. Also, the electronic device 200 may communicate with one or more networks such as a Local Area Network (LAN), a Wide Area Network (WAN), and/or a public network, such as the Internet, through a network adapter 260. Network adapter 260 may communicate with other modules of xxxx device 200 via bus 230. It should be appreciated that although not shown, other hardware and/or software modules may be used in connection with electronic device 200, including, but not limited to: microcode, device drivers, redundant processors, external disk drive arrays, RAID systems, tape drives, data backup storage platforms, and the like.
The embodiment of the application also provides a computer readable storage medium, which is used for storing a computer program, when the computer program is executed, the steps of the method for calculating the tissue segmentation proton dose based on the sketched area in the embodiment of the application are realized, the specific implementation manner of the method is consistent with the implementation manner and the achieved technical effect recorded in the embodiment of the method for calculating the tissue segmentation proton dose based on the sketched area, and part of the contents are not repeated.
The embodiment of the application also provides a computer readable storage medium, which is used for storing a computer program, the computer program is executed to implement the steps of a charger position deviation visualization method in the embodiment of the application, the specific implementation manner of the method is consistent with the implementation manner and the achieved technical effect described in the embodiment of the charger position deviation visualization method, and part of the contents are not repeated.
In the context of this application, a readable storage medium may be any tangible medium that can contain, or store a program for use by or in connection with an instruction execution system, apparatus, or device. Program product 300 may employ any combination of one or more readable media. The readable medium may be a readable signal medium or a readable storage medium. The readable storage medium can be, for example, but is not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or a combination of any of the foregoing. More specific examples (a non-exhaustive list) of the readable storage medium would include the following: an electrical connection having one or more wires, a portable disk, a hard disk, random Access Memory (RAM), read-only memory (ROM), erasable programmable read-only memory (EPROM or flash memory), optical fiber, portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.
The computer readable storage medium may include a data signal propagated in baseband or as part of a carrier wave, with readable program code embodied therein. Such a propagated data signal may take any of a variety of forms, including, but not limited to, electro-magnetic, optical, or any suitable combination of the foregoing. A readable storage medium may also be any readable medium that can transmit, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device. Program code embodied on a readable storage medium may be transmitted using any appropriate medium, including but not limited to wireless, wireline, optical fiber cable, RF, etc., or any suitable combination of the foregoing. Program code for carrying out operations of the present invention may be written in any combination of one or more programming languages, including an object oriented programming language such as Java, C++ or the like and conventional procedural programming languages, such as the C programming language or similar programming languages. The program code may execute entirely on the user's computing device, partly on an associated device, as a stand-alone software package, partly on the user's computing device, partly on a remote computing device, or entirely on the remote computing device or server. In the case of remote computing devices, the remote computing device may be connected to the user computing device through any kind of network, including a Local Area Network (LAN) or a Wide Area Network (WAN), or may be connected to an external computing device (e.g., connected via the Internet using an Internet service provider).
The present application is directed to functional enhancement and use elements, which are emphasized by the patent laws, such as the description and drawings, of the present application, but are not limited to the preferred embodiments of the present application, and therefore, all equivalents and modifications, equivalents, and modifications, etc. of the structures, devices, features, etc. of the present application are included in the scope of the present application.
While embodiments of the present invention have been shown and described, it will be understood that the above embodiments are illustrative and not to be construed as limiting the invention, and that changes, modifications, substitutions and alterations may be made therein by those of ordinary skill in the art without departing from the spirit and scope of the invention, all such changes being within the scope of the appended claims.
Claims (13)
1. The FLASH beam safety locking method is characterized by comprising the following steps:
acquiring the proton charge quantity output by single beam output as a first charge quantity;
judging whether the first charge quantity exceeds a first threshold value;
and performing beam-out control according to the judgment result: if the first charge amount exceeds a first threshold; then a first security lock is performed to prohibit the beam from being output; if not, the beam is allowed to be output, and the beam locking time length is calculated.
2. The method for locking FLASH beam safety according to claim 1, wherein if not, allowing beam to be output, and calculating a beam locking duration includes allowing one-time beam output, determining a beam locking duration, and performing a second safety locking in the beam output locking duration, wherein the first charge amount is less than or equal to a first threshold; wherein during the second security lock no loading of the outgoing beam is allowed.
3. The method for locking FLASH beam safety according to claim 1, wherein the beam-out locking duration is:
T＝N/A y ×3600-t
wherein T is the beam-out locking time; t is the irradiation time, 3600 units are seconds, and N is the first charge amount; a is that y Is a first threshold.
4. The method for locking FLASH beam safety according to claim 1, wherein the beam-out locking duration is:
T＝N/A y ×3600
wherein T is the beam-out locking time; 3600 units are seconds, and N is a first charge amount; a is that y Is a first threshold.
5. The method for locking FLASH beam safety according to claim 1, wherein the beam-out locking duration is:
when the first charge amount is smaller than the second threshold value, t=t1;
when the first charge amount is equal to or greater than the second threshold value and is less than the third threshold value, t=t2;
when the first charge amount is equal to or greater than the third threshold value, t=t3;
wherein T is the beam-out locking time, and T1, T2 and T3 are respectively preset time.
6. The FLASH beam security locking method of claim 1, the first threshold comprising:
A y ＝K×(I y ×3600)
wherein A is y Is a first threshold value, I y For presetting beam outlet proton flow intensity, the unit is nA, K coefficient, K>0。
7. A FLASH beam safety locking device, characterized in that the device comprises:
an output charge amount acquisition module: the proton charge quantity used for obtaining the single beam output is taken as a first charge quantity;
a determining module configured to determine whether the first charge amount exceeds a first threshold;
the execution module is used for carrying out beam-out control according to the judgment result: if the first charge amount exceeds a first threshold; then a first security lock is performed to prohibit the beam from being output; if not, the beam is allowed to be output, and the beam locking time length is calculated.
8. An electronic device comprising a memory and at least one processor, the memory storing a computer program, the at least one processor being configured to implement the following steps when executing the computer program:
acquiring the proton charge quantity output by single beam output as a first charge quantity;
judging whether the first charge quantity exceeds a first threshold value;
and performing beam-out control according to the judgment result: if the first charge amount exceeds a first threshold; then a first security lock is performed to prohibit the beam from being output; if not, the beam is allowed to be output, and the beam locking time length is calculated.
9. The electronic device of claim 8, wherein the at least one processor is configured to obtain the fetch beam lock duration when executing the computer program by:
T＝N/A y ×3600-t
wherein T is the beam-out locking time; t is the irradiation time, 3600 units are seconds, and N is the first charge amount; a is that y Is a first threshold.
10. The electronic device of claim 8, wherein the at least one processor is configured to obtain the fetch beam lock duration when executing the computer program by:
T＝N/A y ×3600
wherein T is the beam-out locking time; 3600 units are seconds, and N is a first charge amount; a is that y Is a first threshold.
11. The electronic device of claim 8, wherein the at least one processor is configured to obtain the fetch beam lock duration when executing the computer program by:
when the first charge amount is smaller than the second threshold value, t=t1;
when the first charge amount is equal to or greater than the second threshold value and is less than the third threshold value, t=t2;
when the first charge amount is equal to or greater than the third threshold value and is less than the fourth threshold value, t=t3;
wherein T is the beam-out locking time, and T1, T2 and T3 are respectively preset time.
12. A FLASH therapy system, the therapy system comprising:
radiotherapy equipment and a FLASH beam safety locking device as claimed in claim 7;
the radiotherapy apparatus is for performing radiotherapy on a patient.
13. A computer readable storage medium storing computer instructions which, when read by a computer, perform the method of any one of claims 1 to 6.
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